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Disease on EC 2.7.1.21 - thymidine kinase

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DISEASE
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Acquired Immunodeficiency Syndrome
3'-azido-3'-deoxythymidine induces deletions in L5178Y mouse lymphoma cells.
Acyclovir-resistant bilateral keratitis associated with mutations in the HSV-1 thymidine kinase gene.
Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS.
Characterization of the DNA polymerase and thymidine kinase genesof herpes simplex virus isolates from AIDS patients in whom acyclovirand foscarnet therapy sequentially failed.
Meningoradiculoneuritis due to acyclovir-resistant varicella zoster virus in an acquired immune deficiency syndrome patient.
Serum thymidine kinase (TK) evaluation in HIV infection.
Serum thymidine kinase in AIDS patients treated with zidovudine.
Serum thymidine kinase--a marker of bone marrow toxicity during treatment with zidovudine.
Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.
Acute Kidney Injury
Apoptosis of the thick ascending limb results in acute kidney injury.
Adenocarcinoma
3'-untranslated region of SP-B mRNA mediates inhibitory effects of TPA and TNF-alpha on SP-B expression.
Adenoviral-mediated suicide gene therapy for hepatic metastases of breast cancer.
Correlation between histological differentiation and DNA-synthesizing enzymes in rat colorectal tumors induced with 1, 2-dimethylhydrazine.
Gene dosage and expression, and enzyme activity of thymidine kinase and thymidylate synthase in xenografted colorectal adenocarcinomas.
Human colon tumors: enzymic and histological characteristics.
Human epithelial ovarian cancer xenotransplants into nude mice can be cured by adenovirus-mediated thymidine kinase gene therapy.
In vitro model of suicide gene therapy for alpha-fetoprotein-producing gastric cancer.
Increased activities of thymidine kinase isozymes in human mammary tumours.
Killing effects of ganciclovir on human pulmonary adenocarcinoma cell A549 transduced with HSV1-TK gene in vitro and in vivo.
Limitations of retrovirus-mediated HSV-tk gene transfer to pulmonary adenocarcinoma cells in vitro and in vivo.
Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer.
Regional versus systemic delivery of recombinant vaccinia virus as suicide gene therapy for murine liver metastases.
Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer.
Serum thymidine kinase is associated with gastric adenocarcinoma.
Similar efficiency of DNA-liposome complexes and retrovirus-producing cells for HSV-tk suicide gene therapy of peritoneal carcinomatosis.
Suicide gene therapy for human uterine adenocarcinoma cells using herpes simplex virus thymidine kinase.
Ternary complex formation and reduced folate in surgical specimens of human adenocarcinoma tissues.
Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker.
Thymidine kinase 1 is a better prognostic marker than Ki-67 for pT1 adenocarcinoma of the lung.
[Growing characteristic of breast adenocarcinoma suicide gene cell line T47D-tk and construction of subcutaneous xenografts]
Adenocarcinoma of Lung
Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma.
Gene Therapy for Human Lung Adenocarcinoma Using a Suicide Gene Driven by a Lung-Specific Promoter Delivered by JC Virus-Like Particles.
High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma.
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression.
Selective gene therapy for human lung adenocarcinoma by tumor-specific expression of herpes simplex virus thymidine kinase gene.
Smoke Chemistry, In Vitro Cytotoxicity, and Genotoxicity Demonstrates Enhanced Toxicity of Cigarillos Compared With Cigarettes.
Thymidine kinase 1 is a better prognostic marker than Ki-67 for pT1 adenocarcinoma of the lung.
Adenocarcinoma, Bronchiolo-Alveolar
Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells.
Adenoma
GENE THERAPY FOR THE TREATMENT OF PITUITARY TUMORS.
Increased thymidine kinase activity in human thyroid toxic adenomas: effects of exposure to epidermal growth factor in vitro.
Isolation of human-mouse somatic cell hybrids producing human prolactin: dominant expression of hormone secretion and regulation.
Properties of partially purified thymidine kinase in adrenal tissue of hyperplasia, adenomatous hyperplasia, adenoma and carcinoma of patients with Cushing's syndrome.
Serum thymidine kinase in colorectal neoplasia.
Adenoma, Pleomorphic
[The effects of HSV-tk suicide gene and wild-type p53 gene on pleomorphic adenoma cells of salivary gland]
Adenomatous Polyposis Coli
Effects of carcinogenesis on colonic thymidine kinase activity in familial adenomatous polyposis.
Thymidine kinase activity in familial adenomatous polyposis.
Adenoviridae Infections
A biochemical investigation of the adenovirus-induced G1 to S phase progression: thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesis.
Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial.
Adrenocortical Carcinoma
Properties of thymidine kinase partially purified from human adrenal glands.
African Swine Fever
African swine fever virus thymidylate kinase gene: sequence and transcriptional mapping.
Altered thymidine kinase activity in culture cells inoculated with African swine fever virus.
Deletion of the thymidine kinase gene induces complete attenuation of the Georgia isolate of African swine fever virus.
Evidence for the evolution of ascoviruses from iridoviruses.
Expression and characterization of the thymidine kinase gene of African swine fever virus.
Isolation and characterization of TK-deficient mutants of African swine fever virus.
Sequence and evolutionary relationships of African swine fever virus thymidine kinase.
The African swine fever virus thymidine kinase gene is required for efficient replication in swine macrophages and for virulence in swine.
AIDS-Related Complex
Serum thymidine kinase--a marker of bone marrow toxicity during treatment with zidovudine.
Alzheimer Disease
Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type.
Neurotropic viruses and Alzheimer's disease: a search for varicella zoster virus DNA by the polymerase chain reaction.
Anemia
Preventive effect of fluvastatin on ulcerative colitis-associated carcinogenesis in mice.
Serum thymidine kinase in congenital dyserythropoietic anaemia type I and homozygous beta-thalassaemia.
Serum thymidine kinase in congenital dyserythropoietic anaemia type III.
Thymidine kinase in megaloblastic anaemia.
[Mantle cell lymphoma as a diagnostic and therapeutic problem]
Anemia, Dyserythropoietic, Congenital
Serum thymidine kinase in congenital dyserythropoietic anaemia type I and homozygous beta-thalassaemia.
Serum thymidine kinase in congenital dyserythropoietic anaemia type III.
Anemia, Hemolytic
Serum Thymidine Kinase 1, Canine-C-Reactive Protein, Haptoglobin, and Vitamin D Concentrations in Dogs with Immune-Mediated Hemolytic Anemia, Thrombocytopenia, and Polyarthropathy.
Anemia, Megaloblastic
Plasma thymidine kinase in megaloblastic anaemia.
Serum thymidine kinase in megaloblastic anaemia.
Thymidine kinase in megaloblastic anaemia.
Arthritis
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Molecular lysis of synovial lining cells by in vivo herpes simplex virus-thymidine kinase gene transfer.
Arthritis, Rheumatoid
Clinical trials in the gene therapy of arthritis.
Astrocytoma
Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
[Preclinical studies on thymidine kinase gene (TK) and gancyclovir system for treatment of malignant astrocytoma]
Bacterial Infections
Biodistribution, PET, and radiation dosimetry estimates of HSV-tk gene expression imaging agent 1-(2'-Deoxy-2'-18F-Fluoro-beta-D-arabinofuranosyl)-5-iodouracil in normal dogs.
Elevation of serum thymidine kinase 1 in a bacterial infection: canine pyometra.
Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil.
Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides.
The use of (14)C-FIAU to predict bacterial thymidine kinase presence: Implications for radiolabeled FIAU bacterial imaging.
Blast Crisis
[Thymidine kinase activity in leukocytes from patients with chronic myeloid leukemia at various periods in the disease]
Bloom Syndrome
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Bluetongue
Bluetongue Virus Particles as Nanoreactors for Enzyme Delivery and Cancer Therapy.
Bone Diseases
Bone marrow biopsy in monoclonal gammopathies: correlations between pathological findings and clinical data. The Cooperative Group for Study and Treatment of Multiple Myeloma.
Brain Diseases
Depletion of the other genome-mitochondrial DNA depletion syndromes in humans.
Brain Injuries
Imaging grafted cells with [18F]FHBG using an optimized HSV1-TK mammalian expression vector in a brain injury rodent model.
Neuroprotective effects of resident microglia following acute brain injury.
Brain Neoplasms
A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma.
Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors.
An improved retroviral vector encoding the herpes simplex virus thymidine kinase gene increases antitumor efficacy in vivo.
Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.
Applications of positron emission tomography in neuro-oncology: A clinical approach.
Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.
Connexins are expressed in primary brain tumors and enhance the bystander effect in gene therapy.
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma.
Developing Implantable Scaffolds to Enhance Neural Stem Cell Therapy for Post-Operative Glioblastoma.
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.
Efficacy of suicide gene therapy in hypoxic rat 9L glioma cells.
Eradication of murine brain tumors by direct inoculation of concentrated high titer-recombinant retrovirus harboring the herpes simplex virus thymidine kinase gene.
Ganciclovir mediated regression of rat brain tumors expressing the herpes simplex virus thymidine kinase imaged by magnetic resonance.
Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir.
Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells.
Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors.
Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy.
Imaging the expression of transfected genes in vivo.
In vitro study on intrathecal use of 5-fluoro-2'-deoxyuridine (FdUrd) for meningeal dissemination of malignant brain tumors.
In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors.
Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study.
Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy.
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene.
Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment.
Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.
Monitoring the Bystander Killing Effect of Human Multipotent Stem Cells for Treatment of Malignant Brain Tumors.
Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients.
New drug delivery system for water-soluble drugs using silicone and its usefulness for local treatment: application of GCV-silicone to GCV/HSV-tk gene therapy for brain tumor.
Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies.
PET reporter gene imaging and ganciclovir-mediated ablation of chimeric antigen receptor T-cells in solid tumors.
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Stem cells as vectors to deliver HSV/tk gene therapy for malignant gliomas.
Stereotactic injection of herpes simplex thymidine kinase vector producer cells (PA317-G1Tk1SvNa.7) and intravenous ganciclovir for the treatment of progressive or recurrent primary supratentorial pediatric malignant brain tumors.
Strategies for gene therapy.
The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats.
Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors.
Thymidine kinase in extracts of human brain tumours.
Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration.
Treatment of rat experimental brain tumors by herpes simplex virus thymidine kinase gene-transduced allogeneic tumor cells and ganciclovir.
Viruses in the treatment of brain tumors.
Breast Neoplasms
207 engineered human amniotic fluid-derived stem cells by expressing Cytosine deaminase (cd) and thymidine kinase (hsv-tk) mediate targeting killing effect in breast cancer cells.
A comparative study: immunohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer.
A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells.
A minimum c-erbB-2 promoter-mediated expression of herpes simplex virus thymidine kinase gene confers selective cytotoxicity of human breast cancer cells to ganciclovir.
A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter.
Adenoviral-mediated suicide gene therapy for hepatic metastases of breast cancer.
Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer.
Adenovirus-mediated tissue-targeted expression of the CDglyTk gene for the treatment of breast cancer.
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Biological heterogeneity of ER-positive breast cancers in the post-menopausal population.
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.
Breast tumour thymidine kinase levels and disease recurrence.
Can thymidine kinase levels in breast tumors predict disease recurrence?
Clinical value of thymidine kinase and tissue polypeptide specific antigen in breast cancer.
Clinicopathological stages and pyrimidine nucleotide synthesis in human mammary carcinomas.
Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects.
Co-expression of thymidine kinase and cathepsin D in 200 primary breast carcinomas.
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Comparison of diagnostic and prognostic performance of two assays measuring thymidine kinase 1 activity in serum of breast cancer patients.
Coordination of transcription of the human 17 beta-hydroxysteroid dehydrogenase type 1 gene (EDH17B2) by a cell-specific enhancer and a silencer: identification of a retinoic acid response element.
Cytosolic thymidine kinase is a specific histopathologic tumour marker for breast carcinomas.
Differential chemosensitivity of breast cancer cells to ganciclovir treatment following adenovirus-mediated herpes simplex virus thymidine kinase gene transfer.
Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model.
Dual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging.
Early prediction of pathologic response to neoadjuvant treatment of breast cancer: use of a cell-loss metric based on serum thymidine kinase 1 and tumour volume.
Effect of hypoxia on human equilibrative nucleoside transporters hENT1 and hENT2 in breast cancer.
Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model.
Elevated levels of thymidine kinase 1 peptide in serum from patients with breast cancer.
Elevated thymidine kinase 1 in serum following neoadjuvant chemotherapy predicts poor outcome for patients with locally advanced breast cancer.
Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir.
EORTC receptor and biomarker study group report analytical and technical evaluation of a thymidine kinase radio-enzymatic assay in breast cancer cytosols.
Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter.
Evaluating Serum Thymidine Kinase 1 in Hormone Receptor Positive Metastatic Breast Cancer Patients Receiving First Line Endocrine Therapy in the SWOG S0226 Trial.
Evaluation of tumour markers as differential diagnostic tool in patients with suspicion of liver metastases from breast cancer.
FISH localization of the soluble thymidine kinase gene (TK1) to human 17q25, a region of chromosomal loss in sporadic breast tumors.
Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase.
HRPAP20: a novel calmodulin-binding protein that increases breast cancer cell invasion.
Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models.
Identification of positive and negative regulatory elements of the human cytochrome P4501A2 (CYP1A2) gene.
In vivo efficacy of folate-targeted lipid-protamine-DNA (LPD-PEG-Folate) complexes in an immunocompetent syngeneic model for breast adenocarcinoma.
Inducible expression of herpes simplex virus thymidine kinase increases sensitivity to ganciclovir but does not enhance bystander effect in breast cancer cells.
Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs.
Inhibition of thymidine kinase in cultured mammary tumor cells by the chemopreventive organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.
Local regression of breast tumors following intramammary ganciclovir administration in double transgenic mice expressing neu oncogene and herpes simplex virus thymidine kinase.
Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter.
Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy.
Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence.
Multiparametric prognostic evaluation of biological factors in primary breast cancer.
Plasma thymidine kinase 1 activity and outcome of ER+ HER2- metastatic breast cancer patients treated with palbociclib and endocrine therapy.
Plasma thymidine kinase activity as a biomarker in patients with luminal metastatic breast cancer treated with palbociclib within the TREnd trial.
Plasma thymidine kinase-1 activity predicts outcome in patients with hormone receptor positive and HER2 negative metastatic breast cancer treated with endocrine therapy.
Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells.
Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors.
Preliminary in vitro efficacy and toxicities studies of the herpes simplex thymidine kinase gene system for the treatment of breast cancer.
Progestin stimulation of thymidine kinase in the human breast cancer cell line T47D.
Prognostic importance of thymidine kinase in colorectal and breast cancer.
Prognostic role of serum thymidine kinase 1 activity in patients with hormone receptor-positive metastatic breast cancer: Analysis of the randomised phase III Evaluation of Faslodex versus Exemestane Clinical Trial (EFECT).
Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer.
Prognostic value of cytosolic thymidine kinase activity as a marker of proliferation in breast cancer.
Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker.
Purification and properties of estrogen-responsive cytoplasmic thymidine kinase from human breast cancer.
Relationship between thymidine kinase 1 before radiotherapy and prognosis in breast cancer patients with diabetes.
Selective targeting and inducible destruction of human cancer cells by retroviruses with envelope proteins bearing short peptide ligands.
Serial evaluation of serum thymidine kinase activity is prognostic in women with newly diagnosed metastatic breast cancer.
Serum thymidine kinase 1 activity as a pharmacodynamic marker of cyclin-dependent kinase 4/6 inhibition in patients with early-stage breast cancer receiving neoadjuvant palbociclib.
Serum thymidine kinase 1 activity in breast cancer.
Serum thymidine kinase 1 levels predict cancer-free survival following neoadjuvant, surgical and adjuvant treatment of patients with locally advanced breast cancer.
Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial.
Serum tumour markers as a diagnostic and prognostic tool in Libyan breast cancer.
STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer.
Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation.
Technical evaluation of thymidine kinase assay in cytosols from breast cancers. EORTC Receptor Study Group Report.
The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody.
Thymidine kinase 1 immunoassay: a potential marker for breast cancer.
Thymidine kinase 1 in serum predicts increased risk of distant or loco-regional recurrence following surgery in patients with early breast cancer.
Thymidine kinase 1 upregulation is an early event in breast tumor formation.
Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.
Thymidine kinase and thymidylate synthase in advanced breast cancer: response to tamoxifen and chemotherapy.
Thymidine kinase as a predictor of response to chemotherapy in advanced breast cancer.
Thymidine kinase as a proliferative marker: clinical relevance in 1,692 primary breast cancer patients.
Thymidine kinase in breast cancer.
Thymidine kinase-1 as a biomarker in breast cancer: estimating prognosis and early recognition of treatment resistance.
Thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell apoptosis in breast cancer cells.
Transcriptional control of thymidine kinase gene expression by estrogen and antiestrogens in MCF-7 human breast cancer cells.
Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences.
[Activity of the enzymes of DNA metabolism in the blood of patients with breast cancer]
[Close relation between fetal thymidine kinase and thymidylate kinase activities in breast cancer]
[Demonstration of fetal-type thymidine kinase in cancer of the breast]
[Growing characteristic of breast adenocarcinoma suicide gene cell line T47D-tk and construction of subcutaneous xenografts]
[Prognostic value of fetal thymidine kinase measurements in breast cancer]
[Prognostic value of thymidine kinase in cancer of the breast]
[Standardization and quality control in the evaluation of proliferation parameters in T1T2, N0N1, M0 breast cancer: multicentric retrospective study II. DNA-ploidy and S-phase fraction]
[Thymidine kinase activity and its isoenzymes in breast tumors]
[Use of enzyme test in chemotherapy of patients with cancer of the breast]
[Value of thymidine kinase in the prediction of response to treatment by chemotherapy or hormone therapy in breast cancer]
Bronchitis
Study of protection by recombinant fowl poxvirus expressing C-terminal nucleocapsid protein of infectious bronchitis virus against challenge.
Burkitt Lymphoma
Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked.
Expression of functional epidermal growth factor receptors in a human hematopoietic cell line.
Induction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analogues.
Carcinogenesis
Alterations in colonic thymidine kinase enzyme activity induced by consumption of various dietary fibers.
Chemopreventive effect of a vitamin D(3) analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis.
Effective suicide gene therapy for leukemia in a model of insertional oncogenesis in mice.
Effects of carcinogenesis on colonic thymidine kinase activity in familial adenomatous polyposis.
Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats.
Preventive effect of fluvastatin on ulcerative colitis-associated carcinogenesis in mice.
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model.
Carcinoid Tumor
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma
A simple and efficient liposome method for transfection of DNA into mammalian cells grown in suspension.
Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system.
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Adenoviral-mediated delivery of the herpes simplex virus thymidine kinase gene selectively sensitizes human ovarian carcinoma cells to ganciclovir.
Adenovirus-mediated suicide gene therapy for experimental bladder cancer.
Adenovirus-mediated tissue-targeted expression of the CDglyTk gene for the treatment of breast cancer.
Antigenic immunostaining patterns in somatic hybrids of human HeLa cells and mouse fibroblasts 3T3.4E propagated in conventional medium and delipidized serum.
Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth.
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells.
Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer.
Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
Cell death of human oral squamous cell carcinoma cell line induced by herpes simplex virus thymidine kinase gene and ganciclovir.
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Clinical Significance and Role of TK1, CEA, CA 19-9 and CA 72-4 levels in Diagnosis of Colorectal Cancers.
Clinical value of thymidine kinase in patients with cervical carcinoma.
Clinicopathological stages and pyrimidine nucleotide synthesis in human mammary carcinomas.
Combination electro-gene therapy using herpes virus thymidine kinase and interleukin-12 expression plasmids is highly efficient against murine carcinomas in vivo.
Combined suicide and cytokine gene therapy for peritoneal carcinomatosis.
Combined suicide and granulocyte-macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity.
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase and cytokine genes expressed in gastric carcinoma cell line SGC7901.
Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model.
Diagnostic usefulness of 5 tumor-markers in patients with primary lung-cancer.
Differences in thermostability of thymidine kinase isoenzymes in normal ovary and ovarian carcinoma.
Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase.
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
Effects of kampo (Japanese herbal) medicine "sho-saiko-to" on DNA-synthesizing enzyme activity in 1,2-dimethylhydrazine-induced colonic carcinomas in rats.
Enzyme pathology of human mesotheliomas.
Establishment and characterization of cell lines from the Walker carcinoma 256 able to grow in suspension culture and deficient in thymidine kinase.
Establishment of mutant FM3A murine mammary carcinoma cell strains transformed with the herpes simplex virus type 1 thymidine kinase gene.
Establishment of mutant murine mammary carcinoma FM3A cell strains transformed with the herpes simplex virus type 2 thymidine kinase gene.
Evaluation of Tumor Markers and Their Impact on Prognosis in Gallbladder, Bile Duct and Cholangiocellular Carcinomas - A Pilot Study.
Experimental gene therapy in mammary and urinary bladder cancer using electrogene transfer.
Exposed proliferation antigen 210 (XPA-210) in renal cell carcinoma (RCC) and oncocytoma: clinical utility and biological implications.
Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome.
Expression of thymidine kinase driven by an endothelial-specific promoter inhibits tumor growth of Lewis lung carcinoma cells in transgenic mice.
Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk.
Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase.
Gastrointestinal tumor markers, other than carcinoembryonic antigen, and alpha fetal protein.
Gene therapy of carcinoma using ultrasound-targeted microbubble destruction.
Herpesvirus type 2-induced thymidine kinase and carcinoma of the cervix.
High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type 1 vector.
Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
Hormonal effects on thymidine kinase activity in normal rat adrenal and in hormone-dependent adrenal carcinoma.
HSV-tk gene therapy for human renal cell carcinoma in nude mice.
HSV-tk gene therapy in head and neck squamous cell carcinoma. Enhancement by the local and distant bystander effect.
Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy.
Identification and characterization of the human retinoid X receptor alpha gene promoter.
Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo.
In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter.
In vivo transfer of a foreign gene to keratinocytes using the hemagglutinating virus of Japan-liposome method.
Increased activities of thymidine kinase isozymes in human colon polyp and carcinoma.
Increased activity of thymidine kinase isozyme in human colon tumor.
Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma.
Inhibition of thymidine kinase from Walker 256 carcinoma by thymidine analogs.
Irreversible enzyme inhibitors. 195. Inhibitors of thymidine kinase from Walker 256 carcinoma derived from thymidine 5'-acetate.
Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.
Methotrexate decreases thymidine kinase activity.
Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy.
Mitochondrial nucleic acids as internal standards for blot hybridization analyses.
Modulation of IdUrd-DNA incorporation and radiosensitization in human bladder carcinoma cells.
Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity.
Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells.
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Noninvasive assessment of cell proliferation in ovarian cancer using [18F] 3'deoxy-3-fluorothymidine positron emission tomography/computed tomography imaging.
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.
Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene.
Pathological features and pyrimidine nucleotide synthesis in human gastric carcinomas.
Plasmid DNA mediated transfer of the herpes simplex virus thymidine kinase gene to a new bromodeoxyuridine resistant variant of human primary lung carcinoma cells.
Prodrug-activated gene therapy: involvement of an immunological component in the "bystander effect".
Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy.
Prognostic significance of thymidine kinase activity in bladder carcinoma.
Properties of partially purified thymidine kinase in adrenal tissue of hyperplasia, adenomatous hyperplasia, adenoma and carcinoma of patients with Cushing's syndrome.
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Rana grylio virus as a vector for foreign gene expression in fish cells.
Relative activities of thymidylate synthetase and thymidine kinase in 1,2-dimethylhydrazine-induced colon carcinomas in rats.
Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.
Retroviral transfer of HSV1-TK gene into human lung cancer cell line.
Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus thymidine kinase gene.
Sedimentation rate and serum thymidine kinase activity: prognostic factors in squamous cell head and neck cancer.
Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Serological thymidine kinase 1 is a prognostic factor in oesophageal, cardial and lung carcinomas.
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Serum deoxythymidine kinase in small cell carcinoma of the lung. Relation to clinical features, prognosis, and other biochemical markers.
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma and Radiofrequency Ablation of Metastases to Lung and Liver.
Serum thymidine kinase 1 is associated with Gleason score of patients with prostate carcinoma.
Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma.
Serum thymidine kinase 1 reflects the progression of pre-malignant and malignant tumors during therapy.
Serum thymidine kinase in diagnosis and follow-up of the small cell carcinoma of the lung.
Significance of thymidine kinase activity in renal cell carcinoma.
STK1p as a prognostic biomarker for overall survival in non-small-cell lung carcinoma, based on real-world data.
Strategy for achieving selective killing of carcinomas.
Structure-activity analysis of antagonism of the feedback inhibition of thymidine kinase.
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
Suppression of aryl hydrocarbon hydroxylase activity in human primary lung carcinoma x mouse hepatoma somatic cell hybrids.
Synthetic radiation-inducible promoters mediated HSV-TK/GCV gene therapy in the treatment of oral squamous cell carcinoma.
Targeted gene expression using a 1.1 kilobase promoter fragment of the tumour-associated antigen EpCAM.
The effect of cyclic nucleotides on DNA polymerase, thymidylate synthetase, thymidine kinase and deoxynucleoside levels of Waler carcinoma.
Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.
Thymidine Kinase 1 and Thymidine Phosphorylase Expression in Non-small Cell Lung Carcinoma in Relation to Angiogenesis and Proliferation.
Thymidine kinase 1: a proliferation marker for determining prognosis and monitoring the surgical outcome of primary bladder carcinoma patients.
Thymidine kinase activity in oral squamous cell carcinoma.
Thymidine kinase activity in serum of renal cell carcinoma patients is a useful prognostic marker.
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Thymidylate synthetase and thymidine kinase activities in DMH-induced colon carcinomas in rats and effects of UFT.
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation.
Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis.
Transient increase in serum thymidine kinase 1 within one week after surgery of patients with carcinoma.
Tumor markers in the diagnosis and follow-up of head and neck cancer: role of CEA, CA 19-9, SCC, TK, and dTTPase.
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter.
Ultrastructure of hybrids derived from electric pulse fusion of human HeLa cells and murine 3T3.4E cells.
Use of a tissue-specific promoter for targeted expression of the herpes simplex virus thymidine kinase gene in cervical carcinoma cells.
Use of gastrin-releasing peptide promoter for specific expression of thymidine kinase gene in small-cell lung carcinoma cells.
Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells.
[All-trans retinoic acid augments the bystander effect of herpes simplex virus thymidine kinase/ganciclovir system in the treatment of tongue carcinoma cell line]
[Combined interleukin-2 and herpes simplex virus thymidine kinase gene therapy for head and neck squamous cell carcinoma]
[Comparative study of the transformation of various thymidine kinase-deficient human and animal cell lines with the thymidine kinase gene of the Herpes simplex virus]
[Effects of hyperthermochemotherapy on activities of DNA-synthesizing enzymes in 1, 2-dimethylhydrazine (DMH)-induced colon carcinomas in rats]
[Gene therapy of human pancreatic carcinoma by recombinant retroviral vector expressing herpes simplex virus thymidine kinase gene]
[Studies on herpes simplex virus thymidine kinase gene and GCV system for treatment of human bladder carcinoma]
[Studies on the thymidine-triphosphate synthesis in malignant tumors. I. Effects of thymidine on deoxyribonucleoside triphosphate pools and deoxyribonucleic acid synthesis (author's trans)]
[Studies on the thymidine-triphosphate synthesis in malignant tumors. II. Effect of hyperthermia, Vitamin K and Cytotoxic agents (author's transl)]
[The adenovirus-mediated HSV-TK/GCV suicide gene system in the treatment of tongue carcinoma cell line]
[The killing effects of two prodrug sensitivity genes on human pancreatic carcinoma cells PC-2]
[Use of the study of DNA metabolism enzyme activities as a test system in the treatment of breast cancer]
Carcinoma 256, Walker
Establishment and characterization of cell lines from the Walker carcinoma 256 able to grow in suspension culture and deficient in thymidine kinase.
Carcinoma, Adenoid Cystic
Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system.
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Carcinoma, Ductal
Thymidine kinase 1 expression in atypical ductal hyperplasia significantly differs from usual ductal hyperplasia and ductal carcinoma in situ: A useful tool in tumor therapy management.
Carcinoma, Ehrlich Tumor
Characterization of the purified cytosolic thymidine kinase from murine ehrlich ascites tumor: interconversion of two different relative molecular weight forms.
Enzyme kinetics of thymidine kinase isoenzymes of Ehrlich ascites tumour.
Lack of correlation between thymidine kinase activity and changes of DNA synthesis with tumour age: an in vivo study in Ehrlich ascites tumour.
Thymidylate synthetase and thymidine kinase activities and methotrexate cytotoxicity during growth of L1210 and Ehrlich ascites tumor.
Carcinoma, Embryonal
Characteristics of the interferon system of an embryonal carcinomal cell are recessive in intraspecific somatic cell hybrids.
Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cells.
DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells.
Translational repression of endogenous thymidine kinase mRNA in differentiating and arresting mouse cells.
Carcinoma, Hepatocellular
5'-nucleotide phosphodiesterase activity of floxuridine-resistant mouse glioma.
A double suicide gene system driven by vascular endothelial growth factor promoter selectively kills human hepatocellular carcinoma cells.
A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma.
Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver.
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy combined with ganciclovir induces hepatoma cell apoptosis.
Adjuvant adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of liver transplantation in patients with advanced hepatocellular carcinoma.
An upstream element from the human insulin receptor gene promoter contains binding sites for C/EBP beta and NF-1.
Analysis of thymidine kinase activity and glucocorticoid-binding capacity in the thymuses of healthy and tumor-bearing chickens.
Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene.
Assessment of ?-Fetoprotein Targeted HSV1-tk Expression in Hepatocellular Carcinoma with In Vivo Imaging.
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Bystander effect caused by suicide gene expression indicates the feasibility of gene therapy for hepatocellular carcinoma.
Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated immune responses and causes apoptotic death of tumor cells in vivo.
CC Ar GG boxes, cis-acting elements with a dual specificity. Muscle-specific transcriptional activation and serum responsiveness.
Changes of tumor vascularity during gene therapy monitored with color Doppler US.
Chicken ovalbumin upstream promoter-transcription factor, hepatocyte nuclear factor 3, and CCAAT/enhancer binding protein control the far-upstream enhancer of the rat alpha-fetoprotein gene.
Comparative analysis of HPLC profile of cytosolic thymidine kinase activity between hepatoma and regenerating liver in rat with reference to phosphorylation.
Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.
Complete cure of established murine hepatocellular carcinoma is achievable by repeated injections of retroviruses carrying the herpes simplex virus thymidine kinase gene.
Connexin32?mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity.
Continuous increase in phosphorylation of cytosolic thymidine kinase during proliferation of rat hepatoma JB1 cells.
Delineation of the insulin-responsive sequence in the rat cytosolic aspartate aminotransferase gene: binding sites for hepatocyte nuclear factor-3 and nuclear factor I.
Differential expression of thymidine kinase gene in two subpopulations of a rat tumour correlates with their tumorigenic and cell division potential.
DNA polymerase and thymidine kinase activities in MC-29 virus-induced transplantable hepatoma and the effect of cytostatic treatment of these activities.
Effect of 5-fluorouracil on the release of thymidine kinase from hepatoma cells in vitro.
Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma.
Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model.
Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma.
Expression of a retrovirally transduced gene under control of an internal housekeeping gene promoter does not persist due to methylation and is restored partially by 5-azacytidine treatment.
Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.
Gene therapy for hepatocellular carcinoma based on tumour-selective suicide gene expression using the alpha-fetoprotein (AFP) enhancer and a housekeeping gene promoter.
Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene.
Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter.
Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir.
Gene therapy of HSV-TK transferred by the EBV based expression vector on experimental hepatocellular carcinoma.
Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma.
Hepatoma cell-specific ganciclovir-mediated toxicity of a lentivirally transduced HSV-TkEGFP fusion protein gene placed under the control of rat alpha-fetoprotein gene regulatory sequences.
Hepatoma-specific gene therapy through retrovirus-mediated and targeted gene transfer using an adenovirus carrying the ecotropic receptor gene.
HSP90? combined with AFP and TK1 improved the diagnostic value for hepatocellular carcinoma.
Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
In vivo antitumor effect of herpes simplex virus thymidine kinase gene therapy in rat hepatocellular carcinoma: feasibility of adenovirus-mediated intra-arterial gene delivery.
Increased concentration of thymidine kinase in rat hepatomas.
Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Inhibition of rat hepatocellular carcinoma tumor growth after multiple infusions of recombinant Ad.AFPtk followed by ganciclovir treatment.
Inhibition of thymidine kinase activity in liver and hepatomas by TTP and d-CTP.
Isolation and characterization of the rat gene for carbamoylphosphate synthetase I.
Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro.
Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.
Methotrexate decreases thymidine kinase activity.
Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: uptake of specific substrates.
Multitracer studies during gene therapy of hepatoma cells with herpes simplex virus thymidine kinase and ganciclovir.
Negative regulation of the alpha-foetoprotein gene in fibroblasts: identification and characterization of cis and trans elements.
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Oncolytic vaccinia virus inhibits human hepatocellular carcinoma MHCC97-H cell proliferation via endoplasmic reticulum stress, autophagy and Wnt pathways.
Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients.
Preclinical and therapeutic utility of HVJ liposomes as a gene transfer vector for hepatocellular carcinoma using herpes simplex virus thymidine kinase.
Protein-DNA interactions at a drug-responsive element of the human apolipoprotein A-I gene.
Regulation of de novo and salvage pathways in chemotherapy.
Retrovirus-mediated gene therapy for hepatocellular carcinoma with reversely oriented therapeutic gene expression regulated by alpha-fetoprotein enhancer/promoter.
Retrovirus-mediated gene therapy for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by human alpha-fetoprotein enhancer directly linked to its promoter.
Retrovirus-mediated gene therapy for human hepatocellular carcinoma transplanted in athymic mice.
Retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for hepatocellular carcinoma.
Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene.
Serum thymidine kinase 1 protein concentration for predicting early progression and monitoring the response to TACE in hepatocellular carcinomas: a network meta-analysis.
Some biochemical mechanisms underlying the impairment of T and B cell immunity in C3HA mice during hepatoma growth.
SP94-Targeted Triblock Copolymer Nanoparticle Delivers Thymidine Kinase-p53-Nitroreductase Triple Therapeutic Gene and Restores Anticancer Function against Hepatocellular Carcinoma in Vivo.
Structural characteristics of cationic liposomes with potent enhancing effect on retroviral transduction into human hepatoma cells.
Studies on thymidylate phosphatase, thymidine kinase and thymidylate kinase activities in some transplantable rat hepatomas.
Suicide gene therapy for hepatocellular carcinoma cells by survivin promoter-driven expression of the herpes simplex virus thymidine kinase gene.
Suicide gene therapy of hepatocellular carcinoma and delivery procedure and route of therapeutic gene in vivo.
The distal enhancer implicated in the developmental regulation of the tyrosine aminotransferase gene is bound by liver-specific and ubiquitous factors.
The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
The gene encoding fibrinogen-beta is a target for retinoic acid receptor-related orphan receptor alpha.
The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPbeta.
Thymidine transport in hepatocytes. An assay for hepatotoxicity.
Tissue preference and differentiation of malignant rat x mouse hybrid cells in chimaeric mouse fetuses.
Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice.
Tumor-associated thymidine kinase in the sera of rats with transplanted hepatomas.
Ultrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice.
Uncoupling of 2-fluoro-2-deoxyglucose transport and phosphorylation in rat hepatoma during gene therapy with HSV thymidine kinase.
Utilization of variant-type of human alpha-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma.
[Changes in DNA and purine nucleotide synthesis in lymphoid cells and sensitivity to glucocorticoids associated with the impairment of differentiation and immune function in mice during tumor growth. Spleen T- and B-lymphocytes]
[Construction of a plasmid vector of fused protein genes driven by human insulin-like growth factor II P3 promoter]
[Delivery of "suicide" thymidine kinase gene of herpes virus in the complex with cationic peptide into human hepatoma cells in vitro]
[Effect of ultrasound microbubble carrying herpes simplex virus thymidine kinase on hepatocellular carcinoma in mice]
[Mitochondrial thymidine kinase and ribonucleotide reductase from rat liver and rat hepatoma 27]
[Thymidine kinase activity, intracellular TTP content and DNA synthesis in transplantable hepatomas and lymphoid tissue of the host]
Carcinoma, Intraductal, Noninfiltrating
Thymidine kinase 1 expression in atypical ductal hyperplasia significantly differs from usual ductal hyperplasia and ductal carcinoma in situ: A useful tool in tumor therapy management.
Carcinoma, Lewis Lung
Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth.
Expression of thymidine kinase driven by an endothelial-specific promoter inhibits tumor growth of Lewis lung carcinoma cells in transgenic mice.
Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.
Carcinoma, Non-Small-Cell Lung
Ectopic expression of herpes simplex virus-thymidine kinase gene in human non-small cell lung cancer cells conferred caspase-activated apoptosis sensitized by ganciclovir.
Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer.
STK1p as a prognostic biomarker for overall survival in non-small-cell lung carcinoma, based on real-world data.
Thymidine Kinase 1 and Thymidine Phosphorylase Expression in Non-small Cell Lung Carcinoma in Relation to Angiogenesis and Proliferation.
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation.
Carcinoma, Ovarian Epithelial
Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1.
Adenovirus-mediated thymidine kinase gene transduction in human epithelial ovarian cancer cell lines followed by exposure to ganciclovir.
Differences in thermostability of thymidine kinase isoenzymes in normal ovary and ovarian carcinoma.
Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer.
Human epithelial ovarian cancer xenotransplants into nude mice can be cured by adenovirus-mediated thymidine kinase gene therapy.
Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma.
Ovarian cancer gene therapy: repeated treatment with thymidine kinase in an adenovirus vector and ganciclovir improves survival in a novel immunocompetent murine model.
Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes.
[Adenovirus-mediated herpes simplex virus thymidine kinase gene transference and combined drug therapy leads to apoptosis of human epithelial ovarian cancer cells]
[Targeted killing effect of mucin-1 single chain antibody targeting, lentivirus-mediated suicide gene therapy and ganciclovir in mucin-1+ ovarian epithelial carcinoma cells]
Carcinoma, Renal Cell
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model.
Exposed proliferation antigen 210 (XPA-210) in renal cell carcinoma (RCC) and oncocytoma: clinical utility and biological implications.
Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome.
HSV-tk gene therapy for human renal cell carcinoma in nude mice.
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma and Radiofrequency Ablation of Metastases to Lung and Liver.
Significance of thymidine kinase activity in renal cell carcinoma.
The Proliferation Marker Thymidine Kinase 1 Level is High in Normal Kidney Tubule Cells Compared to other Normal and Malignant Renal Cells.
Thymidine kinase activity in serum of renal cell carcinoma patients is a useful prognostic marker.
Carcinoma, Small Cell
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Serum deoxythymidine kinase in small cell carcinoma of the lung. Relation to clinical features, prognosis, and other biochemical markers.
Serum thymidine kinase in diagnosis and follow-up of the small cell carcinoma of the lung.
Carcinoma, Squamous Cell
Cell death of human oral squamous cell carcinoma cell line induced by herpes simplex virus thymidine kinase gene and ganciclovir.
Diagnostic usefulness of 5 tumor-markers in patients with primary lung-cancer.
Enzyme activities in human fetal and neoplastic tissues.
Gene therapy of carcinoma using ultrasound-targeted microbubble destruction.
HSV-tk gene therapy in head and neck squamous cell carcinoma. Enhancement by the local and distant bystander effect.
In vivo transfer of a foreign gene to keratinocytes using the hemagglutinating virus of Japan-liposome method.
Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells.
Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy.
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Sedimentation rate and serum thymidine kinase activity: prognostic factors in squamous cell head and neck cancer.
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
The association of herpes simplex virus with squamous carcinoma of the cervix, and studies of the virus thymidine kinase gene.
Tumor markers in the diagnosis and follow-up of head and neck cancer: role of CEA, CA 19-9, SCC, TK, and dTTPase.
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
[Combined interleukin-2 and herpes simplex virus thymidine kinase gene therapy for head and neck squamous cell carcinoma]
Carcinoma, Transitional Cell
Adenovirus-mediated suicide gene therapy for experimental bladder cancer.
Cardiomyopathies
Thymidine kinase 2 and alanyl-tRNA synthetase 2 deficiencies cause lethal mitochondrial cardiomyopathy: case reports and review of the literature.
Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.
Cardiomyopathy, Hypertrophic
Thymidine kinase 2 and alanyl-tRNA synthetase 2 deficiencies cause lethal mitochondrial cardiomyopathy: case reports and review of the literature.
Cell Transformation, Neoplastic
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.
Central Nervous System Neoplasms
Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment.
Preclinical testing of recombinant adenoviral herpes simplex virus-thymidine kinase gene therapy for central nervous system malignancies.
Chickenpox
Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine.
Antibody responses to early antigens of varicella-zoster virus (VZV) during varicella and zoster.
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8.
Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects.
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Compartmentalization of acyclovir-resistant varicella zoster virus: implications for sampling in molecular diagnostics.
Crystal structure of varicella zoster virus thymidine kinase.
Development of immunogenic recombinant Oka varicella vaccine expressing hepatitis B virus surface antigen.
Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants.
Expression of the Varicella Zoster Virus Thymidine Kinase and Cytokines in Patients with Acute Retinal Necrosis Syndrome.
Foreword.
Foscarnet salvage therapy for acyclovir-resistant varicella zoster: report of a novel thymidine kinase mutation and review of the literature.
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Highly purified recombinant varicella Zoster virus thymidine kinase is a homodimer.
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.
Identification and analysis of the simian varicella virus thymidine kinase gene.
Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.
Identification of novel potential inhibitors of varicella-zoster virus thymidine kinase from ethnopharmacologic relevant plants through an in-silico approach.
In-vitro synthesis of functional varicella zoster and herpes simplex viral thymidine kinase.
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase.
Metabolic suicide genes in gene therapy.
Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.
Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells.
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.
Rapid sampling of multiple enzyme reactions.
Regulated expression of artificial chimeric genes contained in retroviral vectors: implications for virus-directed enzyme prodrug therapy (VDEPT) and other gene therapy applications.
Susceptibility of Oka varicella vaccine strain to antiviral drugs.
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.
Testing the sensitivities of noncognate inhibitors to varicella zoster virus thymidine kinase: implications for postherpetic neuralgia therapy with existing agents.
The cytostatic activity of 5-(1-azidovinyl)-2'-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (lambda = 254 nm) exposure.
The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy.
Trans-activation of viral tk promoters by proteins encoded by varicella zoster virus open reading frames 61 and 62.
[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]
[Expression of the varicella zoster virus thymidine kinase and cytokines in patients with acute retinal necrosis syndrome]
Cholangiocarcinoma
Cholangiocarcinoma: molecular imaging-guided radiofrequency hyperthermia-enhanced intratumoral herpes simplex virus thymidine kinase gene therapy.
Evaluation of Tumor Markers and Their Impact on Prognosis in Gallbladder, Bile Duct and Cholangiocellular Carcinomas - A Pilot Study.
Chondrosarcoma
Gene therapy of chondrosarcoma using retrovirus vectors encoding the herpes simplex virus thymidine kinase gene.
Osteosarcoma and chondrosarcoma as targets for virus vectors and herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Choriocarcinoma
Coordination of transcription of the human 17 beta-hydroxysteroid dehydrogenase type 1 gene (EDH17B2) by a cell-specific enhancer and a silencer: identification of a retinoic acid response element.
The human chorionic somatomammotropin gene enhancer is composed of multiple DNA elements that are homologous to several SV40 enhansons.
The POU homeodomain protein Oct-1 binds Cis-regulatory element essential for the human GnRH upstream promoter activity in JEG-3 cells.
Classical Swine Fever
Experimental quantification of transmission of genetically engineered pseudorabies virus.
Role of viral proteins and concanavalin A in in vitro replication of pseudorabies virus in porcine peripheral blood mononuclear cells.
Coinfection
Construction of an infectious clone of canine herpesvirus genome as a bacterial artificial chromosome.
Colitis
Chemopreventive effect of a vitamin D(3) analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis.
Preventive effect of fluvastatin on ulcerative colitis-associated carcinogenesis in mice.
Colonic Neoplasms
Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastases.
Affinity chromatography of thymidine kinase from a rat colon adenocarcinoma.
Anti-tumor effects of engineered mesenchymal stem cells in colon cancer model.
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Antitumor Therapy Based on Cellular Competition.
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression.
Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency.
Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage.
Gene therapy for colon cancer with the herpes simplex thymidine kinase gene.
Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts.
Herpes simplex thymidine kinase gene transfer is required for complete regression of murine colon adenocarcinoma.
Herpes simplex virus thymidine kinase and granulocyte macrophage colony-stimulating factor combination gene therapy in a murine CT26 cell colon cancer model.
Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells.
Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs.
Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate.
In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery.
Inhibition of TNFalpha-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-kappaB- and MAPK-dependent mechanisms.
Kinetic properties of thymidine kinase from the cytosol of a rat colon adenocarcinoma.
Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging.
Novel monoclonal antibodies against thymidine kinase 1 and their potential use for the immunotargeting of lung, breast and colon cancer cells.
Ovarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element.
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells.
Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status.
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene.
Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase.
Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses.
[Clinical significance of DNA-synthesizing enzyme, thymidine kinase, in human colonic cancer]
[The effect of UFT on thymidine kinase and thymidylate synthetase activities and autoradiograph in DMH-induced colon cancer in rat]
Colorectal Neoplasms
A meta-analysis of serological thymidine kinase 1 as a marker for colorectal benign and malignant tumor risk assessment.
A new cell proliferating marker: cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma.
Ablation of tumor cells in vivo by direct injection of HSV-thymidine kinase retroviral vector and ganciclovir therapy.
Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns.
Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer.
Antitumor effects and radiosensitization of cytosine deaminase and thymidine kinase fusion suicide gene on colorectal carcinoma cells.
Cell death associated with genetic prodrug activation therapy of colorectal cancer.
Changes of thymidine kinase (TK) during adjuvant and palliative chemotherapy.
Clinical Significance and Role of TK1, CEA, CA 19-9 and CA 72-4 levels in Diagnosis of Colorectal Cancers.
Correlations of (18)F-fluorothymidine uptake with pathological tumour size, Ki-67 and thymidine kinase 1 expressions in primary and metastatic lymph node colorectal cancer foci.
Effects of 5-fluorouracil derivative UFT on thymidylate synthetase and thymidine kinase in rat colorectal tumors.
Effects of a low dose leucovorin with 5-fluorouracil derivative on colorectal tumors induced with 1,2-dimethylhydrazine in rats.
Effects of carcinogenesis on colonic thymidine kinase activity in familial adenomatous polyposis.
Effects of CO2 pneumoperitoneum on the expression of thymidine kinase 1 and Ki67 in colorectal carcinoma cells.
Human colorectal malignancy and oral UFT.
Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation.
Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer.
Overexpression of m-calpain in human colorectal adenocarcinomas.
Positron emission tomography imaging of human colon cancer xenografts in mice with [18F]fluorothymidine after TAS-102 treatment.
Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors.
Relationship Between Thymidine Kinase 1 Expression and Trifluridine/Tipiracil Therapy in Refractory Metastatic Colorectal Cancer: A Pooled Analysis of 2 Randomized Clinical Trials.
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Serum thymidine kinase in colorectal neoplasia.
Suppression of Cancer Growth by Nonviral Gene Therapy Based on a Novel Reactive Oxygen Species-responsive Promoter.
The Association of Serum Carcinoembryonic Antigen, Carbohydrate Antigen 19-9, Thymidine Kinase, and Tissue Polypeptide Specific Antigen with Outcomes of Patients with Metastatic Colorectal Cancer Treated with Bevacizumab: a Retrospective Study.
The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway.
Thymidine Kinase 1 Loss Confers Trifluridine Resistance without Affecting 5-Fluorouracil Metabolism and Cytotoxicity.
Thymidine kinase activity in familial adenomatous polyposis.
Tumor markers in staging and prognosis of colorectal carcinoma.
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer.
[Clinical value of thymidine kinase activities in sera and tumor tissues of patients with colorectal cancer]
[Cytosine deaminase and thymidine kinase double suicide gene system driven by carcinoembryonic antigen promoter for the treatment of colorectal carcinoma xenograft in nude mice].
[Experimental treatment for human colorectal carcinoma by tissue type specific expression of herpes simplex virus thymidine kinase gene]
Communicable Diseases
Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
Coronary Restenosis
Gene therapy for ischemic heart disease.
Cowpox
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates.
Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs.
KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.
Orthopoxvirus DNA in eurasian lynx, sweden.
Cryptorchidism
Alterations in activities of calmodulin and heat-stable calmodulin-binding protein in rat testis.
Cushing Syndrome
Properties of partially purified thymidine kinase in adrenal tissue of hyperplasia, adenomatous hyperplasia, adenoma and carcinoma of patients with Cushing's syndrome.
Cystic Fibrosis
Altered binding of 125I-labeled calmodulin to a 46.5-kilodalton protein in skin fibroblasts cultured from patients with cystic fibrosis.
Cysts
Thymidine kinase in brain-tumor cysts.
Cytomegalovirus Infections
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Serum thymidine kinase in transplant patients: its relation to cytomegalovirus activity, renal transplant rejection and its use for monitoring of antiviral therapy.
Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P-acyclovir: efficacy against HSV-1 infection in mice.
[(11)C]FMAU and [(18)F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections.
Dementia
Mitochondrial disorders, cognitive impairment and dementia.
Dermatitis, Allergic Contact
Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model.
Diabetes Mellitus
Relationship between thymidine kinase 1 before radiotherapy and prognosis in breast cancer patients with diabetes.
Diabetes Mellitus, Type 1
Multimodality Imaging of {beta}-Cells in Mouse Models of Type I and II Diabetes.
Diabetes Mellitus, Type 2
Relationship between thymidine kinase 1 before radiotherapy and prognosis in breast cancer patients with diabetes.
diacylglycerol kinase (atp) deficiency
Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity.
Diphtheria
Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme.
Enrichment and efficient screening of ES cells containing a targeted mutation: the use of DT-A gene with the polyadenylation signal as a negative selection maker.
Isolation of diphtheria toxin-sensitive mouse cells from a toxin-resistant population transfected with monkey DNA.
Use of H19 regulatory sequences for targeted gene therapy in cancer.
Down Syndrome
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Ectodermal Dysplasia
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Ectromelia
Fine mechanisms of ectromelia virus thymidine kinase-negative mutants avirulence.
Encephalitis
Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported.
Asymptomatic herpes simplex type 1 virus infection of the mouse brain.
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.
Diagnosis of herpes encephalitis via Southern blotting of cerebrospinal fluid DNA amplified by polymerase chain reaction.
Effect of combinations of antiviral drugs on herpes simplex encephalitis.
Nucleotide and amino acid sequence analysis of the thymidine kinase gene of a bovine encephalitis herpesvirus.
Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
Thymidine kinase activity in cerebrospinal fluid of rabbits with Herpesvirus hominis encephalitis.
Use of the polymerase chain reaction to detect herpes simplex virus DNA in paraffin sections of human brain at necropsy.
Encephalitis, Herpes Simplex
Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported.
Diagnosis of herpes encephalitis via Southern blotting of cerebrospinal fluid DNA amplified by polymerase chain reaction.
Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug.
Encephalitis, Japanese
Induction of protective immunity in animals vaccinated with recombinant vaccinia viruses that express PreM and E glycoproteins of Japanese encephalitis virus.
Encephalomyelitis, Venezuelan Equine
Recombinant vaccinia/Venezuelan equine encephalitis (VEE) virus expresses VEE structural proteins.
[The immunogenic properties of a recombinant vaccinia virus with an incorporated DNA copy of the 26S RNA of the Venezuelan equine encephalomyelitis virus]
Endodermal Sinus Tumor
Protein synthesis and tumorigenicity of the cytoplasmic hybrid between rat yolk sac tumor and mouse fibroblastic cell line.
Endometrial Neoplasms
Gene therapy for endometrial carcinoma with the herpes simplex thymidine kinase gene.
Enzootic Bovine Leukosis
Overexpression of interleukin 2 receptor, thymidine kinase and immunoglobulin-associated alpha-1 messenger RNA in a clinical case of enzootic bovine leukosis.
Serum thymidine kinase activity as a useful marker for bovine leukosis.
Utility of Serum Thymidine Kinase Activity Measurements for Cases of Bovine Leukosis with Difficult Clinical Diagnoses.
Ependymoma
Systemic activation of the immune system during ganciclovir treatment following intratumoral herpes simplex virus type 1 thymidine kinase gene transfer in an adolescent ependymoma patient.
Epilepsy
An A8296G mutation in the MT-TK gene of a patient with epilepsy - a disease-causing mutation or rare polymorphism?
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
Epstein-Barr Virus Infections
Analysis of the nucleotide sequence of DNA from the region of the thymidine kinase gene of infectious laryngotracheitis virus; potential evolutionary relationships between the herpesvirus subfamilies.
Erythema Multiforme
Expression of herpes simplex virus DNA fragments located in epidermal keratinocytes and germinative cells is associated with the development of erythema multiforme lesions.
Esophageal Neoplasms
Thymidine kinase 1 is a potential marker for prognosis and monitoring the response to treatment of patients with breast, lung, and esophageal cancer and non-Hodgkin's lymphoma.
Esophageal Squamous Cell Carcinoma
Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma.
Exanthema
Thymidine kinase sequence analysis of herpes simplex virus type 1 strains present in different compartments in an atypical impetiginous rash on the lesional skin of a burn patient.
Eye Infections
The role of herpesvirus type 1 thymidine kinase in experimental ocular infections.
Thymidine kinase and susceptibility to interferon are not involved in the increased virulence of recombinant viruses isolated following mixed ocular infection with HSV strains OD4 and CJ394.
Feline Panleukopenia
Raccoon poxvirus live recombinant feline panleukopenia virus VP2 and rabies virus glycoprotein bivalent vaccine.
Fibroadenoma
Increased activities of thymidine kinase isozymes in human mammary tumours.
Fibroma
Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides.
Fibrosarcoma
In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU.
Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir.
Filariasis
Insights into the structure-function relationship of Brugia malayi thymidylate kinase (BmTMK).
Fowlpox
Comparison of a conserved region in fowlpox virus and vaccinia virus genomes and the translocation of the fowlpox virus thymidine kinase gene.
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases.
Gene translocations in poxviruses: the fowlpox virus thymidine kinase gene is flanked by 15 bp direct repeats and occupies the locus which in vaccinia virus is occupied by the ribonucleotide reductase large subunit gene.
Identification and cloning of the fowlpox virus thymidine kinase gene using vaccinia virus.
Identification of the canarypox virus thymidine kinase gene and insertion of foreign genes.
Quaternary structure of vaccinia virus thymidine kinase.
Role of the fowlpox virus thymidine kinase gene for the growth of FPV recombinants in cell culture.
Similar genetic organization between a region of fowlpox virus DNA and the vaccinia virus HindIII J fragment despite divergent location of the thymidine kinase gene.
Structural analysis of unstable intermediate and stable forms of recombinant fowlpox virus.
Studies of fowlpox virus recombination in the generation of recombinant vaccines.
Vaccination of chickens with a recombinant fowlpox virus containing the hemagglutinin-neuraminidase gene of Newcastle disease virus under the control of the fowlpox virus thymidine kinase promoter.
galactokinase deficiency
Cytosolic thymidine kinase activity in cultured human fibroblasts from individuals with galactokinase deficiency.
Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency.
Thymidine kinase activity in individuals with galactokinase deficiency.
Thymidine-kinase activity of cultured cells from individuals with inherited galactokinase deficiency.
Galactosemias
Cytosolic thymidine kinase activity in cultured human fibroblasts from individuals with galactokinase deficiency.
Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency.
Thymidine kinase activity in individuals with galactokinase deficiency.
Thymidine-kinase activity of cultured cells from individuals with inherited galactokinase deficiency.
Gallbladder Neoplasms
E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer.
Gastroenteritis
Absence of a cAMP-mediated antiabsorptive effect in an undifferentiated jejunal epithelium.
Intracellular processing of the porcine coronavirus transmissible gastroenteritis virus spike protein expressed by recombinant vaccinia virus.
Gastroenteritis, Transmissible, of Swine
Intracellular processing of the porcine coronavirus transmissible gastroenteritis virus spike protein expressed by recombinant vaccinia virus.
Gastrointestinal Diseases
Thymidine kinase in breast cancer.
Gastrointestinal Neoplasms
Correlation of 18F-FLT uptake with equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in gastrointestinal cancer.
Expression and Clinical Significance of Cytokeratin-19 and Thymidine Kinase-1 in Advanced Gastrointestinal Cancer.
Glioblastoma
A New Approach in Gene Therapy of Glioblastoma Multiforme: Human Olfactory Ensheathing Cells as a Novel Carrier for Suicide Gene Delivery.
A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment.
A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group.
A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma.
A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.
Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial.
Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach.
B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.
Bystander effect in glioblastoma cells with a predominant cytoplasmic localization of connexin43.
Clinical protocol. Liposomal gene therapy with the herpes simplex thymidine kinase gene/ganciclovir system for the treatment of glioblastoma multiforme.
Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase.
Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy.
Combined delivery of temozolomide and the thymidine kinase gene for treatment of glioblastoma.
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression.
Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma.
Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells.
Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery.
Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.
Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration.
Encapsulation of packaging cell line results in successful retroviral-mediated transfer of a suicide gene in vivo in an experimental model of glioblastoma.
Experimental therapy of allogeneic solid tumors induced in athymic mice with suicide gene-transducing replication-competent foamy virus vectors.
Gene stereotactic neurosurgery for recurrent malignant gliomas.
Gene therapy for glioblastoma [correction of gliobestome] multiform: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir.
Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and herpes simplex virus thymidine kinase.
Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect.
HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma.
HSV-TK/IL-2 gene therapy for glioblastoma multiforme.
Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.
MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma.
Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models.
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Peptide Micelle-Mediated Delivery of Tissue-Specific Suicide Gene and Combined Therapy with Avastin in a Glioblastoma Model.
Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside.
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas.
Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells.
Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene.
Reducible Poly(Oligo-D-Arginine) as an Efficient Carrier of the Thymidine Kinase Gene in the Intracranial Glioblastoma Animal Model.
Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity.
Targeting glioblastoma-derived pericytes improves chemotherapeutic outcome.
Thymidine kinase gene delivery using curcumin loaded peptide micelles as a combination therapy for glioblastoma.
Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase gene.
Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial.
Glioma
8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET.
A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma.
A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells.
A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography.
A novel bi-cistronic high-capacity gutless adenovirus vector driving constitutive expression of HSV1-TK and Tet-inducible expression of Flt3L for glioma therapeutics.
A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro(R)) after intracerebral administration.
A simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy.
Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir.
Adeno-associated virus vector containing the herpes simplex virus thymidine kinase gene causes complete regression of intracerebrally implanted human gliomas in mice, in conjunction with ganciclovir administration.
Adenoviral-mediated gene transfer into the canine brain in vivo.
Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies.
Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma.
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model.
Antagonism of HSV-tk transfection and ganciclovir treatment on chemotherapeutic drug sensitivity.
Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models.
Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy.
Baculovirus-transduced bone marrow mesenchymal stem cells for systemic cancer therapy.
Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors.
Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma.
Bystander killing effect of tymidine kinase gene-transduced adult bone marrow stromal cells with ganciclovir on malignant glioma cells.
Calmodulin-binding proteins in human Y-79 retinoblastoma and HTB-14 glioma cell lines.
Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse experimental glioma models.
Cellular influx, efflux, and anabolism of 3-carboranyl thymidine analogs: Potential boron delivery agents for neutron capture therapy.
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.
CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.
Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma.
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Comparison of [(14)C]FMAU, [(3)H]FEAU, [(14)C]FIAU, and [(3)H]PCV for Monitoring Reporter Gene Expression of Wild Type and Mutant Herpes Simplex Virus Type 1 Thymidine Kinase in Cell Culture.
Correlation of 4'-[methyl-11C]-thiothymidine uptake with human equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in patients with newly diagnosed gliomas.
Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells.
Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma.
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate.
Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells.
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect".
Efficacy of the bystander effect in the herpes simplex virus thymidine kinase-mediated gene therapy is influenced by the expression of connexin43 in the target cells.
Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.
Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma.
Evaluation of 3'-deoxy-3'-[18F]-fluorothymidine (18F-FLT) kinetics correlated with thymidine kinase-1 expression and cell proliferation in newly diagnosed gliomas.
Evaluation of TK1 targeting carboranyl thymidine analogs as potential delivery agents for neutron capture therapy of brain tumors.
Expression of thymidine kinase is essential to low dose radiation resistance of rat glioma cells.
Gene therapy for brain tumors.
Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.
Gene therapy for pediatric brain tumors.
Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging.
Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells.
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-?B signaling improves the efficacy of immunotherapy in a brain cancer model.
Genetically Engineered Multilineage-Differentiating Stress-Enduring Cells as Cellular Vehicles against Malignant Gliomas.
Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells.
Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.
Herpes simplex virus type 1 thymidine kinase-armed bovine herpesvirus type 4-based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models.
Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice.
Human NT2 Neural Precursor-Derived Tumor-Infiltrating Cells as Delivery Vehicles for Treatment of Glioblastoma.
Image-guided control of transgene expression based on local hyperthermia.
Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.
Imaging the expression of transfected genes in vivo.
In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.
In vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine kinase gene.
In vivo and in vitro glioma cell killing induced by an adenovirus expressing both cytosine deaminase and thymidine kinase and its association with interferon-alpha.
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors.
Increased bax expression is associated with cell death induced by ganciclovir in a herpes thymidine kinase gene-expressing glioma cell line.
Inflammatory thoughts about glioma gene therapy.
Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter.
Integration of adenovirus thymidine kinase suicide-gene therapy with surgery and radiation therapy for malignant glioma.
Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response.
Iron Oxide Nanoparticles Promote Cx43-Overexpression of Mesenchymal Stem Cells for Efficient Suicide Gene Therapy during Glioma Treatment.
Liposomal delivery of the herpes simplex virus thymidine kinase gene in glioma: improvement of cell sensitization to ganciclovir.
Local inflammation and devascularization--in vivo mechanisms of the "bystander effect" in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma.
Local tumour irradiation enhances the anti-tumour effect of a double-suicide gene therapy system in a murine glioma model.
Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment.
Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma.
Microglia used as vehicles for both inducible thymidine kinase gene therapy and MRI contrast agents for glioma therapy.
Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas.
miR-145 is a potential biomarker for predicting clinical outcome in glioblastomas.
Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab.
Molecular imaging of brain tumors personal experience and review of the literature.
Molecular imaging of gliomas.
Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging.
New Variants of Tomato Thymidine Kinase 1 Selected for Increased Sensitivity of E. coli KY895 towards Azidothymidine.
Noninvasive and Local Delivery of Adenoviral-Mediated Herpes Simplex Virus Thymidine Kinase to Treat Glioma Through Focused Ultrasound-Induced Blood-Brain Barrier Opening in Rats.
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.
Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma.
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy.
Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics.
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.
Potent bystander effect in suicide gene therapy using neural stem cells transduced with herpes simplex virus thymidine kinase gene.
Prognostic utility of gene therapy with herpes simplex virus thymidine kinase for patients with high-grade malignant gliomas: a systematic review and meta analysis.
Quantitative kinetics of [124I]FIAU in cat and man.
Radiosensitization of human glioma cells in vitro and in vivo with acyclovir and mutant HSV-TK75 expressed from adenovirus.
Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion.
Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment.
Recent advances in experimental molecular therapeutics for malignant gliomas.
Retroviral transfer of herpes simplex thymidine kinase gene into glioma cells causes targeting of gancyclovir cytotoxic effect.
Retroviruses and DNA: gene therapy for brain tumours.
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Selective expression of foreign genes in glioma cells: use of the mouse myelin basic protein gene promoter to direct toxic gene expression.
Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene.
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Sitimagene ceradenovec: a gene-based drug for the treatment of operable high-grade glioma.
Studies on interactions of dTK-HSV mutants with neurons in vitro.
The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells.
The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats.
The inhibition of thymidine kinase in glial tumor cells by an amino sugar, D-glucosamine.
The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors.
Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.
Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study.
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses.
Tomato thymidine kinase is subject to inefficient TTP feedback regulation.
Toxicity studies in thymidine kinase-deficient herpes simplex virus therapy for malignant astrocytoma.
Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase gene.
Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase.
Treatment of rat gliomas with recombinant retrovirus harboring Herpes simplex virus thymidine kinase suicide gene.
Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir.
Use of thymidine kinase gene-modified endothelial progenitor cells as a vector targeting angiogenesis in glioma gene therapy.
Usefulness of a mouse myelin basic protein promoter for gene therapy of malignant glioma: myelin basic protein promoter is strongly active in human malignant glioma cells.
Using [¹?F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model.
Valproic acid enhances anti-tumor effect of mesenchymal stem cell mediated HSV-TK gene therapy in intracranial glioma.
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho.
[Antiglioma activity of endothelial progenitor cells transduced with HSV-TK via inhibiting angiogenesis in vitro and in vivo.]
[PET-MR in patients with glioblastoma multiforme].
[Selective gene therapy of malignant gliomas using brain-specific promoters: its efficacy and basic investigations]
[Synergistic effect of all-trans retinoic acid and herpes simplex virus thymidine kinase gene on glioma]
Gliosarcoma
Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy.
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma.
Gamma interferon transduced 9L gliosarcoma. Cytokine gene therapy and its relevance to cellular therapy with alloreactive cytotoxic T lymphocytes.
Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity.
Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors.
Imaging expression of adenoviral HSV1-tk suicide gene transfer using the nucleoside analogue FIRU.
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.
Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms.
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents.
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Sustained release of low-dose ganciclovir from a silicone formulation prolonged the survival of rats with gliosarcomas under herpes simplex virus thymidine kinase suicide gene therapy.
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.
Glucose Intolerance
Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance.
Glycogen Storage Disease Type II
Genetic neuromuscular disorders: living the era of a therapeutic revolution. Part 2: diseases of motor neuron and skeletal muscle.
Graft vs Host Disease
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation.
Canine T cells transduced with a herpes simplex virus thymidine kinase gene: a model to study effects on engraftment and control of graft-versus-host disease.
Cellular engineering of HSV-tk transduced, expanded T lymphocytes for graft-versus-host disease management.
Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft.
Development and application of quantitative real time PCR and RT-PCR assays that discriminate between the full-length and truncated herpes simplex virus thymidine kinase gene.
Efficient transduction and selection of human T-lymphocytes with bicistronic Thy1/HSV1-TK retroviral vector produced by a human packaging cell line.
Extensive vitiligo after ganciclovir treatment of GvHD in a patient who had received donor T cells expressing herpes simplex virus thymidine kinase.
Gene therapy strategies for leukemia.
Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene.
Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors.
Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation.
Immunological defects after suicide gene therapy of experimental graft-versus-host disease.
Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction.
Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene.
Monitoring of developing graft-versus-host disease mediated by herpes simplex virus thymidine kinase gene-transduced T cells.
Preservation of graft-versus-infection effects after suicide gene therapy for prevention of graft-versus-host disease.
Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene.
Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire.
Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease.
Hashimoto Disease
Expression of genes for certain enzymes of pyrimidine and purine salvage pathway in peripheral blood leukocytes collected from patients with Graves' or Hashimoto's disease.
Head and Neck Neoplasms
Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model.
Clinical Applicability of the Proliferation Marker Thymidine Kinase 1 in Head and Neck Cancer Patients.
Combination gene therapy for oral cancer in a murine model.
Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors.
Sedimentation rate and serum thymidine kinase activity: prognostic factors in squamous cell head and neck cancer.
Silk-elastin-like hydrogel improves the safety of adenovirus-mediated gene-directed enzyme-prodrug therapy.
The role of interleukin-2 in combination adenovirus gene therapy for head and neck cancer.
Tumor markers in the diagnosis and follow-up of head and neck cancer: role of CEA, CA 19-9, SCC, TK, and dTTPase.
Hearing Loss
Analysis of mitochondrial alterations in Brazilian patients with sensorineural hearing loss using MALDI-TOF mass spectrometry.
Heart Diseases
Autoradiography study and SPECT imaging of reporter gene HSV1-tk expression in heart.
Hematologic Diseases
Thymidine kinase activity in the human bone marrow from various blood diseases.
Hematologic Neoplasms
Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation.
Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker.
Erratum to: Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
NeoR-based transduced T lymphocytes detected by real-time quantitative polymerase chain reaction.
Ribonucleotide reductase and thymidine kinase activities in various cultured cell lines derived from hematologic malignancies.
Serum thymidine kinase activity as a useful marker for bovine leukosis.
Serum thymidine kinase as a marker of disease activity in patients with multiple myeloma.
Serum thymidine kinase in hematologic malignancies.
T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantation.
Hepatitis
Elevated serum thymidine kinase activity in patients with acute viral hepatitis.
Origin of thymidine kinase in the cells infected with infectious canine hepatitis virus.
Recurrent herpes simplex virus hepatitis after liver retransplantation despite acyclovir therapy.
Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.
Hepatitis A
Antiviral potential of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea.
Hepatitis B
Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.
Construction of Oka varicella vaccine expressing human immunodeficiency virus env antigen.
Development of immunogenic recombinant Oka varicella vaccine expressing hepatitis B virus surface antigen.
Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA.
Improved recombinant LC16m0 or LC16m8 vaccinia virus successfully expressing hepatitis B surface antigen.
Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing.
Novel hepatitis B virus infection mouse model using herpes simplex virus type 1 thymidine kinase transgenic mice.
Organization and expression of hepatitis B sequences cloned from hepatocellular carcinoma tissue DNA.
Pre-mRNA processing enhancer (PPE) elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes.
[Double recombinants of the vaccinia virus expressing hepatitis B virus surface antigen and herpes simplex virus thymidine kinase]
Hepatitis C
Improved gene expression by a modified bicistronic retroviral vector.
Hepatitis E
Sexual Dimorphism in Hepatocyte Xenograft Models.
Hepatitis, Infectious Canine
Origin of thymidine kinase in the cells infected with infectious canine hepatitis virus.
Herpes Genitalis
Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes.
Thymidine kinase-deficient herpes simplex virus type 2 genital infection in guinea pigs.
Herpes Simplex
"Suicide" gene for the control of graft-versus-host disease.
"Suicide" gene therapy of breast cancer cells is only cytostatic in vitro but anti-tumoral in vivo on breast MCF7-ras tumor.
"Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene.
'Bystander killing' induces apoptosis and is inhibited by forskolin.
(3)H-Penciclovir ((3)H-PCV) Uptake Assay.
(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity.
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.
18F-FEAU as a radiotracer for herpes simplex virus thymidine kinase gene expression: in-vitro comparison with other PET tracers.
2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent.
2,3-Dihydroxy-quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase.
207 engineered human amniotic fluid-derived stem cells by expressing Cytosine deaminase (cd) and thymidine kinase (hsv-tk) mediate targeting killing effect in breast cancer cells.
3'-Amino thymidine affinity matrix for the purification of herpes simplex virus thymidine kinase.
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
5-Azacytidine-induced reactivation of a herpes simplex thymidine kinase gene.
5-Fluoro-1-(2'-deoxy-2'-fluoro-beta-D-ribofuranosyl) uracil trapping in Morris hepatoma cells expressing the herpes simplex virus thymidine kinase gene.
5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies.
5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression.
8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET.
9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication.
9-(4-Hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, suppresses herpes virus reactivation in mice.
9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.
A "distant" bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor.
A 2.7-kb portion of the 5' flanking region of the murine glycoprotein alphaIIb gene is transcriptionally active in primitive hematopoietic progenitor cells.
A 211-bp enhancer of the rat uncoupling protein-1 (UCP-1) gene controls specific and regulated expression in brown adipose tissue.
A beta-galactosidase expression vector for promoter analysis.
A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone.
A CACCC box-like cis-regulatory element of the Epstein-Barr virus ED-L2 promoter interacts with a novel transcriptional factor in tissue-specific squamous epithelia.
A calcium ionophore-inducible cellular promoter is highly active and has enhancerlike properties.
A candidate live inactivatable attenuated vaccine for AIDS.
A cell cycle model for the tachyzoite of Toxoplasma gondii using the Herpes simplex virus thymidine kinase.
A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect.
A closed culture system for the ex vivo transduction and expansion of human T lymphocytes.
A combined gene delivery by co-transduction of adenoviral and retroviral vectors for cancer gene therapy.
A common set of nuclear factors bind to promoter elements regulated by the retinoblastoma protein.
A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.
A comparison of transcriptional regulatory element activities in transformed and non-transformed rat anterior pituitary cells.
A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter.
A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.
A cryptic transcription promoter in the myb oncogene of avian myeloblastosis virus.
A designed curved DNA segment that is a remarkable activator of eukaryotic transcription.
A DNA recombination-based approach to eliminate papillomavirus infection.
A DNA segment controlling metal-regulated expression of the Drosophila melanogaster metallothionein gene Mtn.
A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.
A dominant positive and negative selectable gene for use in mammalian cells.
A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice.
A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma.
A dual selection based, targeted gene replacement tool for Magnaporthe grisea and Fusarium oxysporum.
A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease.
A fast method for obtaining highly pure recombinant herpes simplex virus type 1 thymidine kinase.
A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells.
A fully automated one pot synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl) guanine for gene therapy studies.
A functional selection of viral genetic elements in cultured cells to identify hepatitis C virus RNA translation inhibitors.
A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells.
A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase.
A general method for the construction of recombinant vaccinia viruses expressing multiple foreign genes.
A generalized technique for deletion of specific genes in large genomes: alpha gene 22 of herpes simplex virus 1 is not essential for growth.
A genetic approach to promoter recognition during trans induction of viral gene expression.
A guanylate kinase/HSV-1 thymidine kinase fusion protein enhances prodrug-mediated cell killing.
A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis.
A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals.
A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer.
A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine.
A mammalian cell line designed to test the mutagenic activity of anti-herpes nucleosides.
A mammary cell-specific enhancer in mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for CTF/NFI and a novel transcription factor, mammary cell-activating factor.
A matched set of cat vectors for rapid mutational analysis of eukaryotic promoters and enhancers.
A minimum c-erbB-2 promoter-mediated expression of herpes simplex virus thymidine kinase gene confers selective cytotoxicity of human breast cancer cells to ganciclovir.
A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target.
A modified human Myogenin promoter that is highly active in alveolar rhabdomyosarcoma.
A Mup promoter-thymidine kinase reporter gene shows relaxed tissue-specific expression and confers male sterility upon transgenic mice.
A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography.
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.
A negative element involved in vimentin gene expression.
A negative regulatory sequence near the mouse beta-maj globin gene associated with a region of potential Z-DNA.
A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.
A neuroblastoma-selective suicide gene therapy approach using the tyrosine hydroxylase promoter.
A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs.
A New Approach in Gene Therapy of Glioblastoma Multiforme: Human Olfactory Ensheathing Cells as a Novel Carrier for Suicide Gene Delivery.
A new method for quantitative determination of tritium-labeled nucleoside kinase products adsorbed on DEAE-cellulose.
A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK).
A New Nucleoside Analogue with Potent Activity against Mutant sr39 Herpes Simplex Virus-1 (HSV-1) Thymidine Kinase (TK).
A new positive/negative selectable marker, puDeltatk, for use in embryonic stem cells.
A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs.
A new set of positive/negative selectable markers for mammalian cells.
A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter.
A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment.
A novel 'sort-suicide' fusion gene vector for T cell manipulation.
A novel bystander effect involving tumor cell-derived Fas and FasL interactions following Ad.HSV-tk and Ad.mIL-12 gene therapies in experimental prostate cancer.
A novel fusion suicide gene yeast CDglyTK plays a role in radio-gene therapy of nasopharyngeal carcinoma.
A novel interferon-gamma regulated human melanoma-associated antigen, gp33-38, defined by monoclonal antibody Me14-D12. II. Molecular cloning of a genomic probe.
A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy.
A novel suicide gene therapy system for p53-mutated cells using a wild-type p53-specific promoter and Cre/loxP switch.
A novel suicide gene therapy targeting the overexpression of eukaryotic initiation factor 4E improves survival in a rat peritoneal carcinomatosis model.
A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections.
A novel, codon-optimised HSVtk(A168H) mutant [TK.007] for suicide gene therapy.
A novel, plasmid-based system for studying gene rearrangements in mammalian cells.
A pattern of partially homologous recombination in mouse L cells.
A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group.
A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma.
A phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients.
A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. Study Group on Gene Therapy of Metastatic Melanoma.
A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma.
A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.
A pilot study of combined suicide/cytokine gene therapy in two patients with end-stage anaplastic thyroid carcinoma.
A Pilot Study of Quality of Life of Patients with Hormone-refractory Prostate Cancer after Gene Therapy.
A pilot study of systemic corticosteroid administration in conjunction with intrapleural adenoviral vector administration in patients with malignant pleural mesothelioma.
A plasmid vehicle suitable for the molecular cloning and characterization of mammalian promoters.
A point mutation in the thymidine kinase gene is responsible for acyclovir-resistance in herpes simplex virus type 2 sequential isolates.
A Positive Selection for Nucleoside Kinases in E. coli.
A potential therapeutic strategy to combat leukemia virus infection.
A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro(R)) after intracerebral administration.
A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging.
A preliminary study on the construction of double suicide gene delivery vectors by mesenchymal stem cells and the in vitro inhibitory effects on SKOV3 cells.
A pseudoreceptor modelling study of the varicella-zoster virus and human thymidine kinase binding sites.
A radioimmunoassay for herpes simplex virus (HSV) thymidine kinase.
A rational approach to the development of antiviral chemotherapy: alternative substrates of herpes simplex virus Type 1 (HSV-1) and Type 2 (HSV-2) thymidine kinase (TK).
A reconstituted telomerase-immortalized human corneal epithelium in vivo: a pilot study.
A replacement vector used to introduce subtle mutations into mouse genes.
A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter.
A role for MAP kinase in the antitumor activity of a nucleoside analog.
A Safety Checkpoint to Eliminate Cancer Risk of the Immune Evasive Cells Derived from Human Embryonic Stem Cells.
A scalable approach to prevent teratoma formation of human embryonic stem cells.
A screen in Escherichia coli for nucleoside analogs that target human immunodeficiency virus (HIV) reverse transcriptase: coexpression of HIV reverse transcriptase and herpes simplex virus thymidine kinase.
A self-inactivating retrovector incorporating the IL-2 promoter for activation-induced transgene expression in genetically engineered T-cells.
A sensitive method for the detection of herpes simplex virus type 2 specific thymidine kinase.
A simple and efficient liposome method for transfection of DNA into mammalian cells grown in suspension.
A simple procedure for expression and purification of selected non-structural (alpha and beta) herpes simplex virus 1 (HSV-1) proteins.
A simple selection system for construction of recombinant gD-negative pseudorabies virus as a vaccine vector.
A simplified one-pot automated synthesis of [18F]FHBG for imaging reporter gene expression.
A simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy.
A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene.
A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.
A spectrophotometric assay for quantitative determination of kcat of herpes simplex virus type 1 thymidine kinase substrates.
A subset of type-specific epitopes map in the amino terminus of herpes simplex virus type 1 glycoprotein B.
A synthetic heat-shock promoter element confers heat-inducibility on the herpes simplex virus thymidine kinase gene.
A tandemly repeated thyroglobulin core promoter has potential to enhance efficacy for tissue-specific gene therapy for thyroid carcinomas.
A tissue-specific transcriptional enhancer is found in the body of the HLA-DR alpha gene.
A tracer kinetic model for 18F-FHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PET.
A transcriptional enhancer essential for the expression of the rat cholecystokinin gene contains a sequence identical to the -296 element of the human c-fos gene.
A transferred NOE study of a tricyclic analog of acyclovir bound to thymidine kinase.
A Transgenic Rat for Specifically Inhibiting Adult Neurogenesis.
A Tri-fusion Reporter Mouse Reveals Tissue-Specific FGF1B Promoter Activity in vivo.
A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.
A tumor suppressor gene, Cx26, also mediates the bystander effect in HeLa cells.
A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas.
A vehicle for DNA transfer and for recovery of transferred genes: lambda Charon phage-pBR322 hybrid.
A versatile method for the coupling of protein to DNA: synthesis of alpha 2-macroglobulin-DNA conjugates.
A virus-specific thymidine kinase in BHK-21 cells infected with herpes simplex virus.
Aanlysis of dCMP deaminase and CDP reductase levels in hamster cells infected by herpes simplex virus.
Ability of structurally related polycyclic aromatic carcinogens to induce homologous recombination between duplicated chromosomal sequences in mouse L cells.
Ablation of neurogenesis attenuates recovery of motor function after focal cerebral ischemia in middle-aged mice.
Ablation of pituitary pro-opiomelanocortin (POMC) cells produces alterations in hypothalamic POMC mRNA levels and midbrain mu opioid receptor binding in a conditional transgenic mouse model.
Ablation of tumor cells in vivo by direct injection of HSV-thymidine kinase retroviral vector and ganciclovir therapy.
Ablation of tumor-derived stem cells transplanted to the central nervous system by genetic modification of embryonic stem cells with a suicide gene.
Abnormal expression of only the CD34 part of a transgenic CD34/herpes simplex virus-thymidine kinase fusion protein is associated with ganciclovir resistance.
Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T lymphoma.
Abundant constitutive expression of the immediate-early 94K protein from cytomegalovirus (Colburn) in a DNA-transfected mouse cell line.
Accumulated HSV1-TK Proteins Interfere with Spermatogenesis Through a Disruption of the Integrity of Sertoli-Germ Cell Junctions.
Accumulation of herpes simplex virus type 1 RNAs of different kinetic classes in the cytoplasm of infected cells.
Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells.
Activating the Expression of Human K-rasG12D Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells.
Activation of a heterologous promoter by human immunodeficiency virus type 1 Tat requires Sp1 and is distinct from the mode of activation by acidic transcriptional activators.
Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA.
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.
Activation of caspase-3 noninvolved in the bystander effect of the herpes simplex virus thymidine kinase gene/ganciclovir (HSV-tk/GCV) system.
Activation of gene expression via CArG boxes during myogenic differentiation.
Activation of metallothionein expression is potentiated by DNA sequences present in the herpes simplex virus thymidine kinase gene.
Activation of the GDNF-inducible transcription factor (GIF) gene promoter by glucocorticoid and progesterone.
Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir.
Activation of the thymidine kinase promoter by herpes simplex virus type 1 immediate early proteins.
Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2.
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
Acute and latent infection by thymidine kinase mutants of herpes simplex virus type 2.
Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.
Acyclovir resistance in a patient with chronic mucocutaneous herpes simplex infection.
Acyclovir resistance in herpes simplex encephalitis.
Acyclovir resistance in herpes simplex virus type 1: biochemical and functional studies on the thymidine kinase of the highly resistant R100 strain.
Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported.
Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty.
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.
Acyclovir-resistant, pathogenic herpesviruses.
Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene.
Addition of a single E2 binding site to the HPV16 E2 long control region enhances killing of HPV-positive cells via HPV E2 protein-regulated HSV-1 thymidine kinase-mediated suicide gene therapy.
Adeno-Associated Virus Liver Transduction Efficiency Measured by in Vivo [(18)F]FHBG Positron Emission Tomography Imaging in Rodents and Nonhuman Primates.
Adeno-associated virus vector containing the herpes simplex virus thymidine kinase gene causes complete regression of intracerebrally implanted human gliomas in mice, in conjunction with ganciclovir administration.
Adenosine- and ADP-phosphorylating capacity of herpes simplex virus-induced thymidine kinase enzyme complex.
Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevance.
Adenoviral herpes simplex virus thymidine kinase gene therapy in an orthotopic lung cancer model.
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Adenoviral insulinoma-associated protein 1 promoter-driven suicide gene therapy with enhanced selectivity for treatment of neuroendocrine cancers.
Adenoviral thymidine kinase prodrug gene therapy inhibits sarcoma growth in vivo.
Adenoviral transduction of a cytosine deaminase/thymidine kinase fusion gene into prostate carcinoma cells enhances prodrug and radiation sensitivity.
Adenoviral vectors efficiently target cell lines derived from selected lymphocytic malignancies, including anaplastic large cell lymphoma and Hodgkin's disease.
Adenoviral-delivered HE4-HSV-tk sensitizes ovarian cancer cells to ganciclovir.
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Adenoviral-mediated delivery of the herpes simplex virus thymidine kinase gene selectively sensitizes human ovarian carcinoma cells to ganciclovir.
Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors.
Adenoviral-mediated suicide gene therapy for hepatic metastases of breast cancer.
Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies.
Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells.
Adenovirus E3-early promoter: sequences required for activation by E1A.
Adenovirus Expressing Both Thymidine Kinase and Soluble PD1 Enhances Antitumor Immunity by Strengthening CD8 T-cell Response.
Adenovirus late sequences linked to herpes simplex virus thymidine kinase may be introduced into eukaryotic cells and transcribed.
Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration.
Adenovirus vector-mediated gene therapy using iodized oil esters for hepatocellular carcinoma in rats.
Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma.
Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome.
Adenovirus-mediated gene therapy for head and neck squamous cell carcinomas.
Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model.
Adenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain.
Adenovirus-mediated gene therapy of experimental gliomas.
Adenovirus-mediated gene therapy of gastric carcinoma using cancer-specific gene expression in vivo.
Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression.
Adenovirus-mediated gene therapy of ovarian cancer in a mouse model.
Adenovirus-mediated gene therapy specific for small cell lung cancer cells using a Myc-Max binding motif.
Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing.
Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer.
Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors.
Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer.
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy combined with ganciclovir induces hepatoma cell apoptosis.
Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model.
Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma.
Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas.
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro.
Adenovirus-mediated suicide gene therapy for experimental bladder cancer.
Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer.
Adenovirus-mediated suicide gene transduction: feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits.
Adenovirus-mediated suicide gene transfer to small cell lung carcinoma using a tumor-specific promoter.
Adenovirus-mediated suicide-gene therapy in an orthotopic murine bladder tumor model.
Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity.
Adenovirus-mediated targeted gene therapy for breast cancer and for purging hematopoietic stem-cell sources.
Adenovirus-mediated thymidine kinase gene therapy for recurrent ovarian cancer: expression of coxsackie-adenovirus receptor and integrins alphavbeta3 and alphavbeta5.
Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up.
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty of the rat carotid artery.
Adenovirus-mediated tumor-specific combined gene therapy using Herpes simplex virus thymidine/ganciclovir system and murine interleukin-12 induces effective antitumor activity against medullary thyroid carcinoma.
Adjuvant adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of liver transplantation in patients with advanced hepatocellular carcinoma.
Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastases.
Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction. HGTRI 0103.
Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene.
Adult Hippocampal Neurogenesis Modulates Fear Learning through Associative and Nonassociative Mechanisms.
Advances in Imaging Gene-Directed Enzyme Prodrug Therapy.
AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor.
Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene.
Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction.
Alkylation-induced frameshift mutagenesis during in vitro DNA synthesis by DNA polymerases alpha and beta.
Allium sativum potentiates suicide gene therapy for murine transitional cell carcinoma.
Allosteric interaction of a herpes simplex viral thymidine kinase with host DNA polymerase alpha in mouse LP1-1 cells.
Alpha interferon and acyclovir treatment of herpes simplex virus in lymphoid cell cultures.
Altered properties of thymidine kinase after infection of mouse fibroblast cells with herpes simplex virus.
Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance.
Amplification of plasmid copy number by thymidine kinase expression in Saccharomyces cerevisiae.
An A/G-rich motif in the rat fibroblast growth factor-2 gene confers enhancer activity on a heterologous promoter in neonatal rat cardiac myocytes.
An adenoviral vector expressing functional heterogeneous proteins herpes simplex viral thymidine kinase and human interleukin-2 has enhanced in vivo antitumor activity against medullary thyroid carcinoma.
An adenovirus vector containing the suicide gene thymidine kinase for a broad application in cancer gene therapy.
An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression.
An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase.
An amplification-promoting sequence from mouse genomic DNA: interaction with a trans-acting factor that also affects gene expression.
An approach to the cloning of cell surface protein genes. Selection by cell sorting of mouse L-cells that express HLA or 4F2 antigens after transformation with total human DNA.
An armed, YB-1-dependent oncolytic adenovirus as a candidate for a combinatorial anti-glioma approach of virotherapy, suicide gene therapy and chemotherapeutic treatment.
An autologous in situ tumor vaccination approach for hepatocellular carcinoma. 1. Flt3 ligand gene transfer increases antitumor effects of a radio-inducible suicide gene therapy in an ectopic tumor model.
An efficient expression vector for stable expression in human liver cells.
An efficient procedure to select and recover recombinant adenovirus vectors.
An Efficient Strategy for Obtaining Mutants by Targeted Gene Deletion in Ophiostoma novo-ulmi.
An enhancer in the first intron of the human purine nucleoside phosphorylase-encoding gene.
An experimental application of gene therapy for human retinoblastoma.
An expression vector inhibits gene expression in Xenopus embryos by antisense RNA.
An HSVtk-mediated local and distant antitumor bystander effect in tumors of head and neck origin in athymic mice.
An improved retroviral vector encoding the herpes simplex virus thymidine kinase gene increases antitumor efficacy in vivo.
An Improved Single-Step Cloning Strategy Simplifies the Agrobacterium tumefaciens-Mediated Transformation (ATMT)-Based Gene-Disruption Method for Verticillium dahliae.
An improved strategy for the synthesis of [(18)F]-labeled arabinofuranosyl nucleosides.
An in vitro nucleoside analog screening method for cancer gene therapy.
An interferon regulatory factor binding site in the U5 region of the bovine leukemia virus long terminal repeat stimulates Tax-independent gene expression.
An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice.
An optimized thymidylate kinase assay, based on enzymatically synthesized 5-[125I]iododeoxyuridine monophosphate and its application to an immunological study of herpes simplex virus thymidine-thymidylate kinases.
An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation.
An S1 nuclease-sensitive region in the first intron of human platelet-derived growth factor A-chain gene contains a negatively acting cell type-specific regulatory element.
An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene.
An upstream region of the rat luteinizing hormone beta gene binds estrogen receptor and confers estrogen responsiveness.
Analysis in Cos-1 cells of processing and polyadenylation signals by using derivatives of the herpes simplex virus type 1 thymidine kinase gene.
Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection.
Analysis of nucleotide sequence variations in herpes simplex virus types 1 and 2, and varicella-zoster virus.
Analysis of phosphorylation pathways of antiherpesvirus nucleosides by varicella-zoster virus-specific enzymes.
Analysis of the nucleotide sequence of DNA from the region of the thymidine kinase gene of infectious laryngotracheitis virus; potential evolutionary relationships between the herpesvirus subfamilies.
Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2.
Analysis of the role of the cysteine 171 residue in the activity of herpes simplex virus type 1 thymidine kinase by oligonucleotide-directed mutagenesis.
Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses.
Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Analysis of the TK enzyme complex induced by HSV types 1 and 2 by means of isoelectric focusing and polyacrylamide gel electrophoresis.
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation.
Angiogenic gene cell therapy using suicide gene system regulates the effect of angiogenesis in infarcted rat heart.
Antagonism of HSV-tk transfection and ganciclovir treatment on chemotherapeutic drug sensitivity.
Anti-angiogenic gene therapy for hepatocellular carcinoma mediated by microbubble-enhanced ultrasound exposure: an in vivo experimental study.
Anti-tumor effects of engineered mesenchymal stem cells in colon cancer model.
Anti-tumor immunity is involved in the thymidine kinase-mediated killing of tumors induced by activated Ki-ras(G12V).
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues.
Antiherpetic activity and mechanism of action of 9-(4-hydroxybutyl)guanine.
Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion.
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.
Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models.
Antitumor effect of secreted Flt3-ligand can act at distant tumor sites in a murine model of head and neck cancer.
Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation.
Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth.
Antitumor effects on human melanoma xenografts of an amplicon vector transducing the herpes thymidine kinase gene followed by ganciclovir.
Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.
Antiviral activity of the marine alga Symphyocladia latiuscula against herpes simplex virus (HSV-1) in vitro and its therapeutic efficacy against HSV-1 infection in mice.
Antiviral potential of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea.
Apoptosis of the thick ascending limb results in acute kidney injury.
Apoptosis-mediated regulation of recombinant human granulocyte colony-stimulating factor production by genetically engineered fibroblasts.
Application of HSVtk suicide gene to X-SCID gene therapy: ganciclovir treatment offsets gene corrected X-SCID B cells.
Application of next-generation sequencing to detect acyclovir-resistant herpes simplex virus type 1 variants at low frequency in thymidine kinase gene of the isolates recovered from patients with hematopoietic stem cell transplantation.
Application of the Cre recombinase/loxP system further enhances antitumor effects in cell type-specific gene therapy against carcinoembryonic antigen-producing cancer.
Applying the herpes simplex virus thymidine kinase/ganciclovir approach to ovarian cancer: an effective in vitro drug-sensitization system.
Arabinose furanosyl thymidine: uptake, phosphorylation and incorporation into DNA of mammalian cells.
Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene.
Assays for noninvasive imaging of reporter gene expression.
Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations.
Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes.
Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy.
Assessment of the long-term transcriptional activity of a 550-bp-long human ?-actin promoter region.
Assessment of therapeutic efficacy of liposomal nanoparticles mediated gene delivery by molecular imaging for cancer therapy.
Assessment of treatment response by autoradiography with (14)C-aminocyclopentane carboxylic acid, (67)Ga-DTPA, and (18)F-FDG in a herpes simplex virus thymidine kinase/ganciclovir brain tumor model.
Association of herpes simplex thymidine kinase gene with chromosome No. 18 in transformed human cells.
Association of the herpes simplex-1 viral gene for thymidine kinase with the human gene for adenylate kinase-1 in biochemically transformed cells.
Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus.
Atrophy of brown adipocytes in the adult mouse causes transformation into white adipocyte-like cells.
Augmentation of gamma-globin gene promoter activity by carboxylic acids and components of the human beta-globin locus control region.
Autonomous replicating sequences from mouse cells which can replicate in mouse cells in vivo and in vitro.
Autopsy neuropathological findings in 'burnt out' herpes simplex encephalitis and use of the polymerase chain reaction to detect viral DNA.
AV.TK-mediated killing of subcutaneous tumors in situ results in effective immunization against established secondary intracranial tumor deposits.
Avian adenovirus vector CELO-TK displays anticancer activity in human cancer cells and suppresses established murine melanoma tumors.
Avian retrovirus integrase-enhanced transgene integration into mammalian cell DNA in vivo.
Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy.
Azidodeoxythymidine and didehydrodeoxythymidine as inhibitors and substrates of the human herpesvirus 8 thymidine kinase.
B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.
Baculovirus-transduced bone marrow mesenchymal stem cells for systemic cancer therapy.
Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer.
Basic peptide system for efficient delivery of foreign genes.
BCR-ABL-expressing cells transduced with the HSV-tk gene die by apoptosis upon treatment with ganciclovir.
Beta-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse.
Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene therapy induces both extrinsic and intrinsic apoptosis in a rat model of bladder cancer.
Binding of hnRNP L to the pre-mRNA processing enhancer of the herpes simplex virus thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs.
Biochemical and immunological characterization of deoxythymidine kinase of thymidine kinaseless HeLa cells biochemically transformed by herpes simplex virus type.
Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells.
Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity.
Biochemical classification of herpes simplex virus types 1 and 2, and of intermediate strains on the basis of different susceptibilities of thymidine kinase to thymidine analogues.
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor.
Biochemical transformation by temperature-sensitive mutants of herpes simplex virus type 1.
Biochemical transformation of LM(TK-) cells by hybrid plasmids containing the coding region of the herpes simplex virus type 1 thymidine kinase gene.
Biochemical transformation of thymidine kinase (TK)-deficient mouse cells by herpes simplex virus type 1 DNA fragments purified from hybrid plasmids.
Biodistribution, PET, and radiation dosimetry estimates of HSV-tk gene expression imaging agent 1-(2'-Deoxy-2'-18F-Fluoro-beta-D-arabinofuranosyl)-5-iodouracil in normal dogs.
Biology of simian virus 40 (SV40) transplantation antigen (TrAg). IX. Analysis of TrAg in mouse cells synthesizing truncated SV40 large T antigen.
Biomimetic cell membrane-coated DNA nanoparticles for gene delivery to glioblastoma.
Biophysical characterization of vaccinia virus thymidine kinase substrate utilization.
BK virus-plasmid expression vector that persists episomally in human cells and shuttles into Escherichia coli.
Bluetongue Virus Particles as Nanoreactors for Enzyme Delivery and Cancer Therapy.
Bone metastasis imaging with SPECT/CT/MRI: A preclinical toolbox for therapy studies.
Both early and late control sequences of SV40 and polyoma promote transcription of Escherichia coli gpt gene in transfected cells.
Both soluble and membrane-bound forms of Flt3 ligand enhance tumor immunity following "suicide" gene therapy in a murine colon carcinoma model.
Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit.
Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging.
Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma.
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.
Bromodeoxyuridine labeling and flow cytometric identification of replicating Saccharomyces cerevisiae cells: lengths of cell cycle phases and population variability at specific cell cycle positions.
Budding yeast as a screening tool for discovery of nucleoside analogs for use in HSV-1 TK suicide-gene therapy.
Building a metal-responsive promoter with synthetic regulatory elements.
Bystander effect caused by suicide gene expression indicates the feasibility of gene therapy for hepatocellular carcinoma.
Bystander effect in glioblastoma cells with a predominant cytoplasmic localization of connexin43.
Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication.
Bystander effect in suicide gene therapy using immortalized neural stem cells transduced with herpes simplex virus thymidine kinase gene on medulloblastoma regression.
Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues.
Bystander killing effect of tymidine kinase gene-transduced adult bone marrow stromal cells with ganciclovir on malignant glioma cells.
Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.
Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.
Bystander Killing of Malignant Glioma by Bone Marrow-derived Tumor-Infiltrating Progenitor Cells Expressing a Suicide Gene.
Bystander or no bystander for gene directed enzyme prodrug therapy.
Bystander-mediated regression of murine neuroblastoma via retroviral transfer of the HSV-TK gene.
Bystander-mediated regression of osteosarcoma via retroviral transfer of the herpes simplex virus thymidine kinase and human interleukin-2 genes.
BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.
C-5 hydroxyethyl and hydroxypropyl acyclonucleosides as substrates for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK): syntheses and biological evaluation.
cAMP stimulates the bystander effect in suicide gene therapy of human choriocarcinoma.
Cancer Cell Targeting with Mouse TERT-Specific Group I Intron of Tetrahymena thermophila.
Cancer chemotherapy using suicide genes.
Cancer gene therapy and immunotherapy (review).
Cancer gene therapy by direct tumor injections of a nonviral T7 vector encoding a thymidine kinase gene.
Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated immune responses and causes apoptotic death of tumor cells in vivo.
Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effect.
Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme.
Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control.
Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.
Canine T cells transduced with a herpes simplex virus thymidine kinase gene: a model to study effects on engraftment and control of graft-versus-host disease.
Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
Carbocyclic analogues of 5-halocytosine nucleosides.
Carcinogens can induce homologous recombination between duplicated chromosomal sequences in mouse L cells.
Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse experimental glioma models.
Cationic liposomes enhance retrovirus-mediated multinucleated cell formation and retroviral transduction.
CC Ar GG boxes, cis-acting elements with a dual specificity. Muscle-specific transcriptional activation and serum responsiveness.
CCAAT/enhancer-binding protein beta (C/EBP beta) binds and activates while hepatocyte nuclear factor-4 (HNF-4) does not bind but represses the liver-type arginase promoter.
CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma.
Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells.
Cell death associated with genetic prodrug activation therapy of colorectal cancer.
Cell death induced by the herpes simplex virus-1 thymidine kinase delivered by human immunodeficiency virus-1-based virus-like particles.
Cell death of human oral squamous cell carcinoma cell line induced by herpes simplex virus thymidine kinase gene and ganciclovir.
Cell-based interferon gene therapy using proliferation-controllable, interferon-releasing mesenchymal stem cells.
Cell-cycle regulatory sequences in a hamster histone promoter and their interactions with cellular factors.
Cell-free synthesis of herpes simplex virus-coded pyrimidine deoxyribonucleoside kinase enzyme.
Cell-specific cytotoxicity of human pancreatic adenocarcinoma cells using rat insulin promoter thymidine kinase-directed gene therapy.
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Cell-specific selection of mutants of a herpes simplex virus recombinant carrying deletions.
Cell-specific targeting of a thymidine kinase/ganciclovir gene therapy system using a recombinant Sindbis virus vector.
Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein.
Cells producing recombinant retrovirus with thymidine kinase gene from Herpes simplex virus suitable for human cancer gene therapy.
Cellular engineering of HSV-tk transduced, expanded T lymphocytes for graft-versus-host disease management.
Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts.
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Changes of tumor vascularity during gene therapy monitored with color Doppler US.
Characterization and susceptibility to antiviral agents of herpes simplex virus type 1 containing a unique thymidine kinase gene with an amber codon between the first and the second initiation codons.
Characterization of a novel liver-specific enhancer in the human prothrombin gene.
Characterization of a silencer element and purification of a silencer protein that negatively regulates the human adenine nucleotide translocator 2 promoter.
Characterization of an estrogen-responsive element implicated in regulation of the rainbow trout estrogen receptor gene.
Characterization of DNA-protein complex formation in nuclear extracts with a sequence from the herpes simplex virus thymidine kinase gene.
Characterization of eukaryotic transcriptional control signals by assay of herpes simplex virus type 1 thymidine kinase.
Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity.
Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.
Characterization of herpes simplex viruses selected in culture for resistance to penciclovir or acyclovir.
Characterization of HIV-1 TAT peptide as an enhancer of HSV-TK/GCV cancer gene therapy.
Characterization of iRGD-Ligand Modified Arginine-Histidine-Rich Peptides for Nucleic Acid Therapeutics Delivery to ?v?3 Integrin-Expressing Cancer Cells.
Characterization of multiple nuclear localization signals in herpes simplex virus type 1 thymidine kinase.
Characterization of mutants of herpes simplex viruses, types 1 and 2, that produce fragments of the thymidine kinase polypeptide.
Characterization of placental transcriptional activation of the human gene for P450scc.
Characterization of pyrimidine deoxyribonucleoside kinase (thymidine kinase) and thymidylate kinase as a multifunctional enzyme in cells transformed by herpes simplex virus type 1 and in cells infected with mutant strains of herpes simplex virus.
Characterization of RNA polymerase II-dependent transcription in Xenopus extracts.
Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1.
Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers.
Characterization of the DNA polymerase and thymidine kinase genesof herpes simplex virus isolates from AIDS patients in whom acyclovirand foscarnet therapy sequentially failed.
Characterization of the hepatitis B virus EnhI enhancer and X promoter complex.
Characterization of the human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) oncogene, kaposin (ORF K12).
Characterization of the mRNA for herpes simplex virus thymidine kinase by cell-free synthesis of active enzyme.
Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.
Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
Characterization of tissue-specific transcription by the human synapsin I gene promoter.
Chemically induced mutagenesis in a shuttle vector with a low-background mutant frequency.
Chicken ovalbumin gene fused to a herpes simplex virus alpha promoter and linked to a thymidine kinase gene is regulated like a viral gene.
Cholangiocarcinoma: molecular imaging-guided radiofrequency hyperthermia-enhanced intratumoral herpes simplex virus thymidine kinase gene therapy.
Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene.
Chromosomal aberrations induced by double strand DNA breaks.
Chromosomal site(s) of integration of Herpes simplex virus type 2 thymidine kinase gene in biochemically transformed human cells.
Chromosome healing in mouse embryonic stem cells.
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials.
Circumventing recombination events encountered with production of a clinical-grade adenoviral vector with a double-expression cassette.
CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.
Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion.
Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes.
Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.
Clinical protocol. Liposomal gene therapy with the herpes simplex thymidine kinase gene/ganciclovir system for the treatment of glioblastoma multiforme.
Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated nerve growth factor receptor.
Clonal analysis of early and late stages of erythroleukemia induced by molecular clones of integrated spleen focus-forming virus.
Cloned mouse mammary tumor virus DNA is biologically active in transfected mouse cells and its expression is stimulated by glucocorticoid hormones.
Cloning and characterization of a retroviral plasmid, pCC1, for combination suicide gene therapy.
Cloning and expression of human deoxyguanosine kinase cDNA.
Cloning and expression of the thyrotropin-releasing hormone receptor from GH3 rat anterior pituitary cells.
Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in K-12.
Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12.
Cloning of the herpes simplex virus type 1 thymidine kinase gene in E. coli K 12: a selective marker for gene transfer into animal cells.
Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements.
Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects.
Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene.
Co-packaging of non-vector RNAs generates replication-defective retroviral vector particles: a novel approach for blocking retrovirus replication.
Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth.
Co-transduction of herpes simplex virus thymidine kinase gene and human interleukin-2 gene into mouse ovarian cancer cell line, OVHM.
Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.
Coexpression of a multidrug-resistance gene (MDR1) and herpes simplex virus thymidine kinase gene as part of a bicistronic messenger RNA in a retrovirus vector allows selective killing of MDR1-transduced cells
Coexpression of the partial androgen receptor enhances the efficacy of prostate-specific antigen promoter-driven suicide gene therapy for prostate cancer cells at low testosterone concentrations.
Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral vector, augments cytotoxicity of transduced human T cells exposed to 5-fluorocytosine.
Coexpression of the Uracil Phosphoribosyltransferase Gene with a Chimeric Human Nerve Growth Factor Receptor/Cytosine Deaminase Fusion Gene, Using a Single Retroviral Vector, Augments Cytotoxicity of Transduced Human T Cells Exposed to 5-Fluorocytosine.
Combination effect of oncolytic adenovirus therapy and herpes simplex virus thymidine kinase/ganciclovir in hepatic carcinoma animal models.
Combination electro-gene therapy using herpes virus thymidine kinase and interleukin-12 expression plasmids is highly efficient against murine carcinomas in vivo.
Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase.
Combination gene therapy for liver metastasis of colon carcinoma in vivo.
Combination gene therapy of lung cancer with conditionally replicating adenovirus and adenovirus-herpes simplex virus thymidine kinase.
Combination of pet imaging with viral vectors for identification of cancer metastases.
Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival.
Combination therapy with suicide and cytokine genes for hepatic metastases of lung cancer.
Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy.
Combinatorial targeting of 2 different steps in adenoviral DNA replication by herpes simplex virus thymidine kinase and artificial microRNA expression for the inhibition of virus multiplication in the presence of ganciclovir.
Combine cancer gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and Herpes simplex thymidine kinase suicide gene.
Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma.
Combined delivery of temozolomide and the thymidine kinase gene for treatment of glioblastoma.
Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcinoma.
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.
Combined suicide and granulocyte-macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity.
Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes.
Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir.
Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cells.
Comparative Analysis of T Cell Imaging with Human Nuclear Reporter Genes.
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
Comparative genomic analysis of the HNF-4alpha transcription factor gene.
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Comparative study of the genetic variability in thymidine kinase and glycoprotein B genes of herpes simplex viruses by the RNase A mismatch cleavage method.
Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells.
Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.
Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.
Comparison of HSV-1 thymidine kinase-dependent and -independent inhibition of replication-competent adenoviral vectors by a panel of drugs.
Comparison of intron-dependent and intron-independent gene expression.
Comparison of polymorphism of thymidine kinase gene and restriction fragment length polymorphism of genomic DNA in herpes simplex virus type 1.
Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression.
Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches.
Comparison of the in vitro and in vivo antiherpes virus activities of the acyclic nucleosides, acyclovir (Zovirax) and 9-[(2-hydroxy-1-hydroxymethylethoxy)methyl]guanine (BWB759U).
Comparison of the transcriptional properties of the Friend and Moloney retrovirus long terminal repeats: importance of tandem duplications and of the core enhancer sequence.
Comparison of thymidine kinase activities indiced in cells productively infected with herpesvirus saimiri and herpes simplex virus.
Comparison of two methods in the determination of the sensitivity of 84 herpes simplex virus (HSV) type 1 and 2 clinical isolates to acyclovir and alpha-interferon.
Comparison of [(14)C]FMAU, [(3)H]FEAU, [(14)C]FIAU, and [(3)H]PCV for Monitoring Reporter Gene Expression of Wild Type and Mutant Herpes Simplex Virus Type 1 Thymidine Kinase in Cell Culture.
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression.
Competition and complementation between thymidine kinase-negative and wild-type herpes simplex virus during co-infection of mouse trigeminal ganglia.
Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus types 1 and 2.
Complete cure of established murine hepatocellular carcinoma is achievable by repeated injections of retroviruses carrying the herpes simplex virus thymidine kinase gene.
Complete regression of metastatic de-differentiated liposarcoma with engineered mesenchymal stromal cells with dTRAIL and HSV-TK.
Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study.
Computational modeling and functional analysis of Herpes simplex virus type-1 thymidine kinase and Escherichia coli cytosine deaminase fusion protein.
Computer-aided active-site-directed modeling of the herpes simplex virus 1 and human thymidine kinase.
Conditional ablation and recovery of forebrain neurogenesis in the mouse.
Conditional ablation of dendritic cells in transgenic mice.
Conditional ablation of neurones in transgenic mice.
Conditional cell suicide using dox-dependent caspase-2 expression.
Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells.
Conditional Cytotoxic Anti-HIV Gene Therapy for Selectable Cell Modification.
Conditional depletion of neurogenesis inhibits long-term recovery after experimental stroke in mice.
Conditional expression of a suicide gene by the telomere reverse transcriptase promoter for potential post-therapeutic deletion of tumorigenesis.
Conditional reduction of human immunodeficiency virus type 1 replication by a gain-of-herpes simplex virus 1 thymidine kinase function.
Conditionally replicating adenovirus SG500-expressed mutant Dm-dNK gene for breast cancer therapy.
Configurations of a two-tiered amplified gene expression system in adenoviral vectors designed to improve the specificity of in vivo prostate cancer imaging.
Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma.
Connexin 43 SUMOylation improves gap junction functions between liver cancer stem cells and enhances their sensitivity to HSVtk/GCV.
Connexin 43-enhanced suicide gene therapy using herpesviral vectors.
Connexin-independent ganciclovir-mediated killing conferred on bystander effect-resistant cell lines by a herpes simplex virus-thymidine kinase-expressing colon cell line.
Connexin32?mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity.
Connexins are expressed in primary brain tumors and enhance the bystander effect in gene therapy.
Consequences of thyroid hormone deficiency induced by the specific ablation of thyroid follicle cells in adult transgenic mice.
Conservative intrachromosomal recombination between inverted repeats in mouse cells: association between reciprocal exchange and gene conversion.
Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities.
Conserved sequences near the early transcription start sites of vaccinia virus.
Construction and characterization of a recombinant plasmid encoding the gene for the thymidine kinase of Herpes simplex type 1 virus.
Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences.
Construction and characterization of a stably transformed HeLa cell line in which the expression of bovine herpesvirus 1 ICP0 (BICP0) is induced by tetracycline.
Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase and cytokine genes expressed in gastric carcinoma cell line SGC7901.
Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1.
Construction and validation of improved triple fusion reporter gene vectors for molecular imaging of living subjects.
Construction of a differentiated human hepatocyte cell line expressing the herpes simplex virus-thymidine kinase gene.
Construction of a dominant selective marker useful for gene transfer studies in animal cells.
Construction of a ganciclovir-sensitive lentiviral vector to assess the influence of angiopoietin-3 and soluble Tie2 on glioma growth.
Construction of a herpes simplex virus/varicella-zoster virus (HSV/VZV) thymidine kinase recombinant with the pathogenic potential of HSV and a drug sensitivity profile resembling that of VZV.
Construction of a mammalian transducing vector from the genome of Moloney murine leukemia virus.
Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen.
Construction of gene therapy vectors targeting adrenocortical cells: enhancement of activity and specificity with agents modulating the cyclic adenosine 3',5'-monophosphate pathway.
Construction of gene therapy vectors targeting thyroid cells: enhancement of activity and specificity with histone deacetylase inhibitors and agents modulating the cyclic adenosine 3',5'-monophosphate pathway and demonstration of activity in follicular and anaplastic thyroid carcinoma cells.
Construction of mutant TKGFP for real-time imaging of temporal dynamics of HIF-1 signal transduction activity mediated by hypoxia and reoxygenation in tumors in living mice.
Construction of plasmid vector pAFP-HSVtk-IRES2-EGFP and its effect on the cytotoxicity of ganciclovir to hepatocellular carcinoma.
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus.
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus. 1982.
Construction of rat cell lines that contain potential morphologically transforming regions of the herpes simplex virus type 2 genome.
Construction of strains for rapid homokaryon purification after integration of constructs at the histidine-3 ( his-3) locus of Neurospora crassa.
Contribution of a combination of ponicidin and acyclovir/ganciclovir to the antitumor efficacy of the herpes simplex virus thymidine kinase gene therapy system.
Control of expression of the herpes simplex virus thymidine kinase gene in biochemically transformed cells.
Control of Herpes simplex virus thymidine kinase gene expression in Saccharomyces cerevisiae by a yeast promoter sequence.
Control of the expression of a herpes simplex virus thymidine kinase gene incorporated into thymidine kinase-deficient mouse cells.
Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus.
Cooperation between CCAAT and octamer motifs in the distal sequence element of the rat U3 small nucleolar RNA promoter.
Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance.
Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer.
Cooperative therapeutic effects of herpes simplex virus thymidine kinase gene/ganciclovir system and chemotherapeutic agents on prostate cancer in vitro.
Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure.
Corrected splicing of a chicken ovalbumin gene transcript in mouse L cells.
Correlation of glucocorticoid receptor binding sites on MMTV proviral DNA with hormone inducible transcription.
Correlation of the virus sequence content and biological properties of cells carrying the herpes simplex virus type 2 thymidine kinase gene.
Cotargeting tumor and stroma in a novel chimeric tumor model involving the growth of both human prostate cancer and bone stromal cells.
Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells.
Cre/loxP system controlled by specific promoter for radiation-mediated gene therapy of hepatoma.
Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.
CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes.
CRISPR/Cas9-Mediated Knockin Application in Cell Therapy: A Non-viral Procedure for Bystander Treatment of Glioma in Mice.
Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir.
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma.
Curcumin plays a synergistic role in combination with HSV-TK/GCV in inhibiting growth of murine B16 melanoma cells and melanoma xenografts.
Cure of mice with established metastatic friend leukemia cell tumors by a combined therapy with tumor cells expressing both interferon-alpha 1 and herpes simplex thymidine kinase followed by ganciclovir.
Current progress in suicide gene therapy for cancer.
Cytogenetic detection of a trans-species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolized in HSV thymidine kinase gene-transfected Chinese hamster ovary cells.
Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir.
Cytopathogenicity, drug susceptibility, and thymidine kinase activity of a retinovirulent herpes simplex virus type 2.
Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy.
Cytosine methylation in CTF and Sp1 recognition sites of an HSV tk promoter: effects on transcription in vivo and on factor binding in vitro.
Cytotoxic effect of acyclovir on cultured mammalian cells to which herpesvirus thymidine kinase gene was introduced.
Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells.
Cytotoxicity and antiangiogenesis by fibroblast growth factor 2-targeted Ad-TK cancer gene therapy.
Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells.
D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.
Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.
Death and Proliferation Time Course of Stem Cells Transplanted in the Myocardium.
Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells.
Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma.
Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii.
Delayed morbidity and mortality of albumin/SV40 T-antigen transgenic mice after insertion of an alpha-fetoprotein/herpes virus thymidine kinase transgene and treatment with ganciclovir.
Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft.
Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression.
Delivery of herpes simplex thymidine kinase bystander effect by engineered human mesothelial cells for the treatment of ovarian cancer.
Demethylation and expression of methylated plasmid DNA stably transfected into HeLa cells.
Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics.
Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus.
Density functional studies on herpes simplex virus type 1 thymidine kinase-substrate interactions: the role of Tyr-172 and Met-128 in thymine fixation.
Deoxypyrimidine kinases of herpes simplex viruses types 1 and 2: comparison of serological and structural properties.
Deoxyribonuclease I sensitivity of plasmid genomes in teratocarcinoma-derived stem and differentiated cells.
Deoxyribonucleic acid-mediated gene transfer in mammalian cells: molecular analysis of unstable transformants and their progression to stability.
Deoxyribonucleoside triphosphate pools in herpes simplex type 1 infected cells.
Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology.
Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice.
Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice.
Derivation of a triple mosaic adenovirus for cancer gene therapy.
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides.
Detection of an IE responsive element(s) in the BamHI J fragment of human cytomegalovirus AD169.
Detection of exogenous gene sequences in dissolved DNA from aquatic environments.
Detection of herpes simplex virus DNA sequences in corneal transplant recipients by polymerase chain reaction assays.
Detection of herpes simplex virus thymidine kinase and latency-associated transcript gene sequences in human herpetic corneas by polymerase chain reaction amplification.
Detection of herpes simplex virus thymidine kinase polypeptides in cells labeled with 35S-methionine.
Detection of immediate early protein ICP27/IE63 and thymidine kinase in the course of reactivation of latent herpes simplex virus 1 infection.
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate.
Detection of mutations within the thymidine kinase gene of herpes simplex virus type 1 by denaturing gradient gel electrophoresis.
Detection of viral DNA in neonatal herpes encephalitis autopsy tissues by solution-phase PCR: comparison with pathology and immunohistochemistry.
Determination of mRNA fate by different RNA polymerase II promoters.
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
Development and application of quantitative real time PCR and RT-PCR assays that discriminate between the full-length and truncated herpes simplex virus thymidine kinase gene.
Development and use of an in vitro HSV-tk forward mutation assay to study eukaryotic DNA polymerase processing of DNA alkyl lesions.
Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors.
Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase.
Development of a competitive PCR method for in vitro and in vivo quantification of herpes simplex virus thymidine kinase and neomycin resistance-expressing cells used in a clinical trial.
Development of a Conditionally Replicating Pseudorabies Virus for HER-2/neu-overexpressing Bladder Cancer Therapy.
Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene.
Development of a positive-negative selection procedure for gene targeting in fish cells.
Development of a universal anti-polyethylene glycol reporter gene for noninvasive imaging of PEGylated probes.
Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum.
Development of anti-tumor immunity against a non-immunogenic mammary carcinoma through in vivo somatic GM-CSF, IL-2, and HSVtk combination gene therapy.
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.
Development of gene therapy using prostate-specific membrane antigen promoter/enhancer with Cre Recombinase/LoxP system for prostate cancer cells under androgen ablation condition.
Development of genetically modified eliminable human dermal fibroblast feeder cells for ocular surface regeneration medicine.
Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery.
Development of novel cationic liposomes for efficient gene transfer into peritoneal disseminated tumor.
Development of novel selective cell ablation in the mammary gland and brain to study cell-cell interactions and chemoprevention.
Development of synthetic promoters for radiation-mediated gene therapy.
Development of Systemic Immunologic Responses Against Hepatic Metastases During Gene Therapy for Peritoneal Carcinomatosis With Retroviral HS-tk and Ganciclovir.
Developments in suicide genes for preclinical and clinical applications.
Diagnosis of herpes encephalitis via Southern blotting of cerebrospinal fluid DNA amplified by polymerase chain reaction.
Diagnostic imaging of herpes simplex virus encephalitis using a radiolabeled antiviral drug: autoradiographic assessment in an animal model.
Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus.
Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.
Different transmission rates of herpesvirus thymidine kinase reporter transgenes from founder male parents and male parents of subsequent generations.
Differential chemosensitivity of breast cancer cells to ganciclovir treatment following adenovirus-mediated herpes simplex virus thymidine kinase gene transfer.
Differential effects of base-pair mismatch on intrachromosomal versus extrachromosomal recombination in mouse cells.
Differential ganciclovir-mediated cell killing by glutamine 125 mutants of herpes simplex virus type 1 thymidine kinase.
Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase.
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
Differential metabolism of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by equine herpesvirus type 1- and herpes simplex virus-infected cells.
Differential mutation patterns in thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 clones passaged in the presence of acyclovir or penciclovir.
Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy.
Differential susceptibility of human neural cell types in culture to infection with herpes simplex virus.
Differential transcriptional regulation by the alpha- and gamma-catalytic subunit isoforms of cAMP-dependent protein kinase.
Differential transfection efficiency rates of the GM-CSF gene into human renal cell carcinoma lines by lipofection.
Differential transient and long-term expression of DNA sequences introduced into T-lymphocyte lines.
Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes.
Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors.
Direct evidence for the absence of intercellular trafficking of VP22 fused to GFP or to the herpes simplex virus thymidine kinase.
Direct intratumoral gene transfer of the herpes simplex virus thymidine kinase gene with DNA-liposome complexes: growth inhibition of tumors and lack of localization in normal tissues.
Direct-repeat analysis of chromatid interactions during intrachromosomal recombination in mouse cells.
Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo.
Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling.
Discrete positive and negative thyroid hormone-responsive transcription regulatory elements of the rat growth hormone gene.
Dissection of the mouse N-ras gene upstream regulatory sequences and identification of the promoter and a negative regulatory element.
Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors.
Distinct sequence elements involved in the glucocorticoid regulation of the mouse mammary tumor virus promoter identified by linker scanning mutagenesis.
Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs.
Distribution, persistency, toxicity, and lack of replication of an E1A-deficient adenoviral vector after intracardiac delivery in the cotton rat.
Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids.
Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and Ganglia.
DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells.
DNA length is a critical parameter for eukaryotic transcription in vivo.
DNA methylation and the regulation of globin gene expression.
DNA methylation directs a time-dependent repression of transcription initiation.
DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage.
DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions.
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.
DNA sequence responsible for the amplification of adjacent genes.
DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo.
DNA sequences downstream from the vitamin D response element of the rat osteocalcin gene are required for ligand-dependent transactivation.
DNA sequences required for transcription in vivo of the human corticotropin-beta-lipotropin precursor gene.
DNA-liposome complexes transduction of herpes simplex virus thymidine kinase renders human tongue cancer cell line sensitive to ganciclovir in vitro.
DNA-mediated gene transfer efficiency is enhanced by ionizing and ultraviolet irradiation of rodent cells in vitro. I. Kinetics of enhancement.
DNA-mediated gene transfer in Chinese hamster ovary cells: clonal variation in transfer efficiency.
DNA-mediated gene transfer in Friend leukemia cells by cotransfection of simian virus 40 DNA with herpes simplex virus thymidine kinase DNA.
DNA-mediated gene transfer without carrier DNA.
DNA-mediated gene transfer: recombination between cotransferred DNA sequences and recovery of recombinants in a plasmid.
DNA-transformed murine teratocarcinoma cells: regulation of expression of simian virus 40 tumor antigen in stem versus differentiated cells.
Do there exist synergistic antitumor effects by coexpression of herpes simplex virus thymidine kinase with cytokine genes on human gastric cancer cell line SGC7901?
Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene.
Donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene: detailed immunological function following add-back after haplo-identical transplantation.
Double cos site vectors: simplified cosmid cloning.
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal interference in a malignant glioma model.
Drosophila P element-enhanced transfection in mammalian cells.
Drug resistance in the opportunistic pathogens Candida albicans and Candida glabrata.
Drug resistance of herpes simplex virus type 1--structural considerations at the molecular level of the thymidine kinase.
Dual-vector prodrug activator gene therapy using retroviral replicating vectors.
Dynamics of the antiviral activity of N-methanocarbathymidine against herpes simplex virus type 1 in cell culture.
E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes.
E1A RNA transcripts amplify adenovirus-mediated tumor reduction.
E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex.
E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer.
Early immune response against retrovirally transduced herpes simplex virus thymidine kinase-expressing gene-modified T cells coinfused with a T cell-depleted marrow graft: an altered immune response?
Early immune response against retrovirally-transduced Herpes Simplex Virus-thymidine kinase-expressing gene-modified T cells coinfused with a T cell-depleted marrow graft : an altered immune response?
EBV replicon vector system enhances transgene expression in vivo: applications to cancer gene therapy.
Ecdysterone regulatory elements function as both transcriptional activators and repressors.
Ectopic expression of herpes simplex virus-thymidine kinase gene in human non-small cell lung cancer cells conferred caspase-activated apoptosis sensitized by ganciclovir.
Effect of a thymidine kinase inhibitor (L-653,180) on antiviral treatment of experimental herpes simplex virus infection in mice.
Effect of acyclovir and presence of cellular and viral thymidine kinase activity in herpes simplex virus infected cells. Brief report.
Effect of adenoviral-mediated thymidine kinase transduction and ganciclovir therapy on tumor-associated endothelial cells.
Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability.
Effect of butyrate on the expression of microinjected or transfected genes.
Effect of combinations of antiviral drugs on herpes simplex encephalitis.
Effect of combined cytostatic cyclosporin A and cytolytic suicide gene therapy on the prevention of experimental graft-versus-host disease.
Effect of distance between homologous sequences and 3' homology on the frequency of retroviral reverse transcriptase template switching.
Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect".
Effect of in vitro mutations in a vaccinia virus early promoter region monitored by herpes simplex virus thymidine kinase expression in recombinant vaccinia virus.
Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells.
Effect of methylation on expression of microinjected genes.
Effect of nucleotide excision repair in human cells on intrachromosomal homologous recombination induced by UV and 1-nitrosopyrene.
Effect of suicide gene therapy in combination with immunotherapy on antitumour immune response & tumour regression in a xenograft mouse model for head & neck squamous cell carcinoma.
Effect of the rabbit alphas1-casein gene distal enhancer on the expression of a reporter gene in vitro and in vivo.
Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells.
Effect on substrate binding of an alteration at the conserved aspartic acid-162 in herpes simplex virus type 1 thymidine kinase.
Effective suicide gene therapy for leukemia in a model of insertional oncogenesis in mice.
Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration.
Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas.
Effects of an internal transcription unit and its orientation on retrovirus titre and expression.
Effects of an upstream DNA curvature on the strength of HSV thymidine kinase promoter.
Effects of bicistronic lentiviral vector-mediated herpes simplex virus thymidine kinase/ganciclovir system on human lens epithelial cells.
Effects of deletions on expression of the herpes simplex virus thymidine kinase gene from the intact viral genome: the amino terminus of the enzyme is dispensable for catalytic activity.
Effects of IMP dehydrogenase inhibitors on the phosphorylation of ganciclovir in MOLT-4 cells before and after herpes simplex virus thymidine kinase gene transduction.
Effects of mutations on herpes simplex virus 1 thymidine kinase functionality: An in vitro assay based on detection of monophosphate forms of acyclovir and thymidine using HPLC/DAD.
Effects of orientation and position on the activity of a herpes simplex virus immediate early gene far-upstream region.
Effects of oxidative and alkylating damage on microsatellite instability in nontumorigenic human cells.
Effects of retroviral-mediated herpes simplex virus thymidine kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo.
Effects of the phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes.
Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-? and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line.
Efficacy of 2'-nor-cyclicGMP in treatment of experimental herpes virus infections.
Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model.
Efficacy of lentivirus-mediated and MUC1 antibody-targeted VP22-TK/GCV suicide gene therapy for ovarian cancer.
Efficacy of repeated adenoviral suicide gene therapy in a localized murine tumor model.
Efficacy of the bystander effect in the herpes simplex virus thymidine kinase-mediated gene therapy is influenced by the expression of connexin43 in the target cells.
Efficiency of introns from various origins in fish cells.
Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1 thymidine kinase substitution mutant with reduced neuronal replication.
Efficient expression of cloned complementary DNAs for secretory proteins after injection into Xenopus oocytes.
Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site.
Efficient gene delivery into epstein-barr virus (EBV)-transformed human B cells mediated by replication-defective herpes simplex virus-1 (HSV-1): A gene therapy model for EBV-related B cell malignancy.
Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model.
Efficient introduction of contents of liposomes into cells using HVJ (Sendai virus).
Efficient labeling of fission yeast Schizosaccharomyces pombe with thymidine and BUdR.
Efficient repair of DNA double-strand breaks in malignant cells with structural instability.
Efficient retroviral gene transfer of a Tat-regulated herpes simplex virus thymidine kinase gene for HIV gene therapy.
Efficient suicide gene therapy of transduced and distant untransduced ovary tumors is correlated with significant increase of intratumoral T and NK cells.
Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model.
Efficient transcription of a Caenorhabditis elegans heat shock gene pair in mouse fibroblasts is dependent on multiple promoter elements which can function bidirectionally.
Efficient transformation of Dictyostelium discoideum amoebae.
Electrophoresis of thymidine kinase activity synthesized by cells transformed by herpes simplex virus.
Elimination of proliferating cells from CNS grafts using a Ki67 promoter-driven thymidine kinase.
Elimination of SOX2/OCT4-Associated Prostate Cancer Stem Cells Blocks Tumor Development and Enhances Therapeutic Response.
Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene.
Embryonic stem cell grafting in normal and infarcted myocardium: serial assessment with MR imaging and PET dual detection.
Encapsidation and expression of the herpes thymidine kinase gene in polyoma virus.
Encapsidation sequences for spleen necrosis virus, an avian retrovirus, are between the 5' long terminal repeat and the start of the gag gene.
Encapsulation of packaging cell line results in successful retroviral-mediated transfer of a suicide gene in vivo in an experimental model of glioblastoma.
Endogenous Neural Stem/Progenitor Cells Stabilize the Cortical Microenvironment after Traumatic Brain Injury.
Engineered RNase P ribozymes increase their cleavage activities and efficacies in inhibiting viral gene expression in cells by enhancing the rate of cleavage and binding of the target mRNA.
Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons.
Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase.
Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase.
Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation.
Engineering of Systematic Elimination of a Targeted Chromosome in Human Cells.
Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase.
Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma.
Enhanced combined tumor-specific oncolysis and suicide gene therapy for prostate cancer using M6 promoter.
Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.
Enhanced ganciclovir killing and bystander effect of human tumor cells transduced with a retroviral vector carrying a herpes simplex virus thymidine kinase gene mutant.
Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: applications for prodrug-activating gene therapy.
Enhanced growth suppression in esophageal carcinoma cells using adenovirus-mediated fusion gene transfer (uracil phosphoribosyl transferase and herpes simplex virus thymidine kinase).
Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene.
Enhanced rate of conversion or recombination of markers within a region of unique sequence in the herpes simplex virus genome.
Enhanced toxicity of purine nucleoside analogs in cells expressing Drosophila melanogaster nucleoside kinase mutants.
Enhanced tumor cell killing in the presence of ganciclovir by herpes simplex virus type 1 vector-directed coexpression of human tumor necrosis factor-alpha and herpes simplex virus thymidine kinase.
Enhancement of DNA-mediated gene transfer by inhibitors of autophagic-lysosomal function.
Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator.
Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant.
Enhancement of tumor killing using a combination of tumor immunization and HSV-tk suicide gene therapy.
Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir.
Entrapment of retroviral vector producer cells in three-dimensional alginate scaffolds for potential use in cancer gene therapy.
Entry of B lymphocytes into the persistent cell pool in non-immunized mice is not accompanied by somatic mutation of VH genes.
Enzyme-targeted, nucleoside-based radiopharmaceuticals for scintigraphic monitoring of gene transfer and expression.
Enzymology and pathogenicity in mice of a herpes simplex virus type 1 mutant resistant to 2'-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodocytosine.
Epstein-Barr virus nuclear protein 2 transactivates a cis-acting CD23 DNA element.
Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation.
Epstein-Barr virus-based vector improves the tumor cell killing effect of pituitary tumor in HVJ-liposome-mediated transcriptional targeting suicide gene therapy.
Eradication of murine brain tumors by direct inoculation of concentrated high titer-recombinant retrovirus harboring the herpes simplex virus thymidine kinase gene.
Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.
Erratum to: Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene.
Establishment and use of a cell line expressing HSV-1 thymidine kinase to characterize viral thymidine kinase-dependent drug-resistance.
Establishment of a rat cell line inducible for the expression of human cytomegalovirus immediate-early gene products by protein synthesis inhibition.
Establishment of latency in mice by herpes simplex virus 1 recombinants that carry insertions affecting regulation of the thymidine kinase gene.
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes.
Establishment of mutant FM3A murine mammary carcinoma cell strains transformed with the herpes simplex virus type 1 thymidine kinase gene.
Establishment of mutant murine mammary carcinoma FM3A cell strains transformed with the herpes simplex virus type 2 thymidine kinase gene.
Establishment of parameters for optimal transduction efficiency and antitumor effects with purified high-titer HSV-TK retroviral vector in established solid tumors.
Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators.
Estrogen and progesterone receptor-binding sites on the chicken vitellogenin II gene: synergism of steroid hormone action.
Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma.
Evaluation of a C57BL/6J × 129S1/SvImJ Hybrid Nestin-Thymidine Kinase Transgenic Mouse Model for Studying the Functional Significance of Exercise-Induced Adult Hippocampal Neurogenesis.
Evaluation of a putative vitamin D response element in the avian calcium binding protein gene.
Evaluation of a viral thymidine kinase gene for suicide selection in transfected mosquito cells.
Evaluation of an E1E4-deleted adenovirus expressing the herpes simplex thymidine kinase suicide gene in cancer gene therapy.
Evaluation of combined gene regulatory elements for transcriptional targeting of suicide gene expression to malignant melanoma.
Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging.
Evaluation of ganciclovir-mediated enhancement of the antitumoral effect in oncolytic, multimutated herpes simplex virus type 1 (G207) therapy of brain tumors.
Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer.
Evaluation of herpes simplex virus 1 thymidine kinase-mediated trapping of (131)I FIAU and prodrug activation of ganciclovir as a synergistic cancer radio/chemotherapy.
Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model.
Evaluation of prodrugs ability to induce effective ablation of cells transduced with viral thymidine kinase gene.
Evaluation of Prostate-Specific Membrane Antigen as an Imaging Reporter.
Evaluation of scopadulciol-related molecules for their stimulatory effect on the cytotoxicity of acyclovir and ganciclovir against Herpes simplex virus type 1 thymidine kinase gene-transfected HeLa cells.
Evidence for a functional glucocorticoid responsive element in the Epstein-Barr virus genome.
Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.
Evidence for an involvement of thymidine kinase in the excision repair of ultraviolet-irradiated herpes simplex virus in human cells.
Evidence for intrachromosomal gene conversion in cultured mouse cells.
Evidence for transcriptional interference in a dual-luciferase reporter system.
Evidence that deletion of coding sequences in the 5' end of the thymidine kinase gene of herpes simplex virus type 1 affects the stability of the gene products.
Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide.
Ex vivo delivery of suicide genes into melanoma cells using epidermal growth factor receptor-specific Fab immunogene.
Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene.
Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA.
Exogenous p53 and ASPP2 expression enhances rAdV-TK/ GCV-induced death in hepatocellular carcinoma cells lacking functional p53.
Experimental autoimmune encephalomyelitis repressed by microglial paralysis.
Experimental gene therapy in mammary and urinary bladder cancer using electrogene transfer.
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells.
Expression and stabilization of microinjected plasmids containing the herpes simplex virus thymidine kinase gene and polyoma virus DNA in mouse cells.
Expression from an internal AUG codon of herpes simplex thymidine kinase gene inserted in a retrovirus vector.
Expression from herpesvirus promoters does not relieve the intron requirement for cytoplasmic accumulation of human beta-globin mRNA.
Expression in COS-1 cells of Epstein-Barr virus nuclear antigen from a complete gene and a deleted gene.
Expression of a cellular gene cloned in herpes simplex virus: rabbit beta-globin is regulated as an early viral gene in infected fibroblasts.
Expression of a mouse U1b gene in mouse L cells.
Expression of a retrovirally transduced gene under control of an internal housekeeping gene promoter does not persist due to methylation and is restored partially by 5-azacytidine treatment.
Expression of a Tat-inducible herpes simplex virus-thymidine kinase gene protects acyclovir-treated CD4 cells from HIV-1 spread by conditional suicide and inhibition of reverse transcription.
Expression of an immediate early polypeptide and activation of a viral origin of DNA replication in cells containing a fragment of herpes simplex virus DNA.
Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene.
Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia.
Expression of functional estrogen receptors and galanin messenger ribonucleic acid in immortalized luteinizing hormone-releasing hormone neurons: estrogenic control of galanin gene expression.
Expression of H-2, laminin and SV40 T and TASA on differentiation of transformed murine teratocarcinoma cells.
Expression of hepatitis B viral antigens in animal cells transfected with viral DNA.
Expression of herpes simplex virus DNA fragments located in epidermal keratinocytes and germinative cells is associated with the development of erythema multiforme lesions.
Expression of herpes simplex virus glycoprotein C from a DNA fragment inserted into the thymidine kinase gene of this virus.
Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis.
Expression of herpes simplex virus thymidine kinase in Toxoplasma gondii attenuates tachyzoite virulence in mice.
Expression of herpes simplex virus thymidine kinase, mediated by vaccinia virus early promoters.
Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay.
Expression of herpes simplex virus type I thymidine kinase gene in Escherichia coli.
Expression of herpes virus thymidine kinase in Neurospora crassa.
Expression of human beta-interferon cDNA under the control of a thymidine kinase promoter from herpes simplex virus.
Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector.
Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity.
Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing.
Expression of porcine FSHbeta subunit promoter-driven herpes simplex virus thymidine kinase gene in transgenic rats.
Expression of SV40 T antigen polypeptides in cells biochemically transformed by plasmids containing the herpes simplex virus thymidine kinase gene and the genome of an SV40tsA mutant.
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.
Expression of the cyclic AMP-dependent protein kinase (PKA) catalytic subunit from a herpes simplex virus vector extends the survival of rat sympathetic neurons in the absence of NGF.
Expression of the glycoprotein of vesicular stomatitis virus by infectious adenovirus vectors.
Expression of the Herpes simplex virus thymidine kinase gene in Saccharomyces cerevisiae.
Expression of the herpes thymidine kinase gene in Xenopus laevis oocytes: an assay for the study of deletion mutants constructed in vitro.
Expression of the human cardiac actin gene in differentiating rat skeletal myoblasts.
Expression of the major histocompatibility antigens HLA-A2 and HLA-B7 by DNA-mediated gene transfer.
Expression of the viral thymidine kinase gene in herpes simplex virus-transformed L cells.
Expression of the X gene of hepatitis B virus.
Expression of transferred thymidine kinase genes is controlled by methylation.
Extensive vitiligo after ganciclovir treatment of GvHD in a patient who had received donor T cells expressing herpes simplex virus thymidine kinase.
Ex Vivo Selection of Transduced Hematopoietic Stem Cells for Gene Therapy of ?-Hemoglobinopathies.
Factors governing expression of the herpes simplex virus gene for thymidine kinase in clonal derivatives of transformed mouse L cells.
Failure of founder transgenic male mice to transmit an attenuated HSV thymidine kinase transgene results from mosaicism and sperm competition.
Fate and structure of DNA microinjected into mouse TK-L cells.
Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys.
Fertile homozygous transgenic mice expressing a functional truncated herpes simplex thymidine kinase delta TK gene.
Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys.
FIAU: From reporter gene imaging to imaging of bacterial proliferation.
Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice.
Fine-resolution analysis of products of intrachromosomal homeologous recombination in mammalian cells.
Fine-structure analysis of the processing and polyadenylation region of the herpes simplex virus type 1 thymidine kinase gene by using linker scanning, internal deletion, and insertion mutations.
Flagellar and acrosomal abnormalities associated with testicular HSV-tk expression in the mouse.
Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
Flt3L in Combination With HSV1-TK-mediated Gene Therapy Reverses Brain Tumor-induced Behavioral Deficits.
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.
Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model.
Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase.
Folding and self-assembly of herpes simplex virus type 1 thymidine kinase.
Foreign DNA introduced by calcium phosphate is integrated into repetitive DNA elements of the mouse L cell genome.
Foreword.
Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus.
From thallium scan to molecular imaging.
Frontline: An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo.
Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice.
Functional analyses of albumin expression in a series of hepatocyte cell lines and in primary hepatocytes.
Functional analysis of a transrepressor domain in the hepatitis C virus core protein.
Functional analysis of the glucocorticoid regulatory elements present in the mouse mammary tumor virus long terminal repeat. A synthetic distal binding site can replace the proximal binding domain.
Functional analysis of the mouse H-2Kb gene promoter in embryonal carcinoma cells.
Functional coexpression of HSV-1 thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression.
Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation.
Functional expression of the Herpes simplex virus thymidine kinase gene in Escherichia coli K-12.
Functional expression of thymidine kinase in human leukaemic and colorectal cells, delivered as EGFP fusion protein by herpesvirus saimiri-based vector.
Functional genomics and radioisotope-based imaging procedures.
Functional identification of genes up- and down-regulated by glucocorticoids in AtT-20 pituitary cells using an enhancer trap.
Functional long-term thymidine kinase suicide gene expression in human T cells using a herpesvirus saimiri vector.
Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus.
Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene.
Functional suppression in mammalian cells of nonsense mutations in the herpes simplex virus thymidine kinase gene by suppressor tRNA genes.
Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancer.
Fusion enzymes containing HSV-1 thymidine kinase mutants and guanylate kinase enhance prodrug sensitivity in vitro and in vivo.
Fusion of herpes simplex virus thymidine kinase to VP22 does not result in intercellular trafficking of the protein.
Fusion of the Human Immunodeficiency Virus Type 1 Tat Protein Transduction Domain to Thymidine Kinase Increases Bystander Effect and Induces Enhanced Tumor Killing In Vivo.
Fusion of the human immunodeficiency virus type 1 tat protein transduction domain to thymidine kinase increases bystander effect and induces enhanced tumor killing in vivo.
Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor growth.
Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice.
Gamma interferon transduced 9L gliosarcoma. Cytokine gene therapy and its relevance to cellular therapy with alloreactive cytotoxic T lymphocytes.
Gamma-rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk/ganciclovir on cancer cells.
Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP).
Ganciclovir and penciclovir, but not acyclovir, induce apoptosis in herpes simplex virus thymidine kinase-transformed baby hamster kidney cells.
Ganciclovir mediated regression of rat brain tumors expressing the herpes simplex virus thymidine kinase imaged by magnetic resonance.
Ganciclovir nucleotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene.
Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer.
Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation?
Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase.
Ganciclovir-induced ablation non-proliferating thyrocytes expressing herpesvirus thymidine kinase occurs by p53-independent apoptosis.
Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase gene.
Ganciclovir-sensitive acute graft-versus-host disease in mice receiving herpes simplex virus-thymidine kinase-expressing donor T cells in a bone marrow transplantation setting.
Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene.
Gap junctions in human glioblastomas: implications for suicide gene therapy.
Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.
Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo.
GCV modulates the antitumoural efficacy of a replicative adenovirus expressing the Tat8-TK as a late gene in a pancreatic tumour model.
GCV phosphates are transferred between HeLa cells despite lack of bystander cytotoxicity.
Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy.
Gene and cell therapy for relapsed leukemia after allo-stem cell transplantation.
Gene and other biological therapies for vascular diseases.
Gene delivery by HVJ-liposome in the experimental gene therapy of murine glioma.
Gene delivery by lentivirus vectors an overview.
Gene delivery to carcinoma cells via novel non-viral vectors: nanoparticle tracking analysis and suicide gene therapy.
Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus.
Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination.
Gene stereotactic neurosurgery for recurrent malignant gliomas.
Gene targeting by a vector with hairpin-shaped oligonucleotide caps.
Gene Targeting to Hepatomas (AFP).
Gene targeting using a mouse HPRT minigene/HPRT-deficient embryonic stem cell system: inactivation of the mouse ERCC-1 gene.
Gene therapeutic approaches for medullary thyroid carcinoma treatment.
Gene therapy against an experimental glioma using adeno-associated virus vectors.
Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase.
Gene therapy for adult T cell leukemia using human immunodeficiency virus vector carrying the thymidine kinase gene of herpes simplex virus type 1.
Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.
Gene therapy for brain tumors.
Gene therapy for brain tumors: Basic developments and clinical implementation.
Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
Gene therapy for colon cancer with the herpes simplex thymidine kinase gene.
Gene therapy for endometrial carcinoma with the herpes simplex thymidine kinase gene.
Gene therapy for glioblastoma [correction of gliobestome] multiform: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir.
Gene therapy for hepatocellular carcinoma based on tumour-selective suicide gene expression using the alpha-fetoprotein (AFP) enhancer and a housekeeping gene promoter.
Gene therapy for hepatocellular carcinoma using two recombinant adenovirus vectors with alpha-fetoprotein promoter and Cre/lox P system.
Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene.
Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter.
Gene therapy for high grade gliomas.
Gene therapy for malignant mesothelioma: a novel approach for an incurable cancer with increased incidence in Louisiana.
Gene therapy for malignant pleural mesothelioma.
Gene therapy for metastatic malignant melanoma: evaluation of tolerance to intratumoral injection of cells producing recombinant retroviruses carrying the herpes simplex virus type 1 thymidine kinase gene, to be followed by ganciclovir administration.
Gene therapy for oral cancer: efficient delivery of a 'suicide gene' to murine oral cancer cells in physiological milieu.
Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
Gene therapy for prostate cancer: toxicological profile of four HSV-tk transducing adenoviral vectors regulated by different promoters.
Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir.
Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Gene therapy in brain tumours: implications of the size of glioblastoma on its curability.
Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase.
Gene therapy of carcinoma using ultrasound-targeted microbubble destruction.
Gene therapy of chondrosarcoma using retrovirus vectors encoding the herpes simplex virus thymidine kinase gene.
Gene therapy of epithelial ovarian cancer using adenoviral vectors.
Gene therapy of established medullary thyroid carcinoma with herpes simplex viral thymidine kinase in a rat tumor model: relationship of bystander effect and antitumor efficacy.
Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene.
Gene therapy of hepatocellular carcinoma in vitro and in vivo in nude mice by adenoviral transfer of the Escherichia coli purine nucleoside phosphorylase gene.
Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir.
Gene therapy of HSV-TK transferred by the EBV based expression vector on experimental hepatocellular carcinoma.
Gene therapy of liver tumors with human liver-specific nanoparticles.
Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells.
Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir.
Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection.
Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging.
Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and herpes simplex virus thymidine kinase.
Gene Therapy of Uterine Leiomyoma: Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Treatment Inhibits Growth of Human and Rat Leiomyoma Cells in vitro and in a Nude Mouse Model.
Gene therapy strategies for leukemia.
Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer.
Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect.
Gene therapy using tissue-specific replication competent HSV.
Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells.
Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin.
Gene therapy vectors harboring AFP regulatory sequences. Preparation of an adenoviral vector.
Gene therapy with GM-CSF, interleukin-4 and herpes simplex virus thymidine kinase shows strong antitumor effect on lung cancer.
Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells.
Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma.
Gene transfer applied to the modulation of alloreactivity.
Gene transfer in bovine blastocysts using replication-defective retroviral vectors packaged with Gibbon ape leukemia virus envelopes.
Gene transfer into human prostate adenocarcinoma cells with an adenoviral vector: Hyperthermia enhances a double suicide gene expression, cytotoxicity and radiotoxicity.
Gene transfer into mouse lyoma cells by electroporation in high electric fields.
Gene transfer into sympathetic preganglionic neurons in vivo using a non-replicating thymidine kinase-deficient herpes simplex virus type 1.
Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors.
Gene transfer, expression, and molecular cloning of the human transferrin receptor gene.
Gene transfer: DNA microinjection compared with DNA transfection with a very high efficiency.
Gene trap screening using negative selection: identification of two tandem, differentially expressed loci with potential hematopoietic function.
Generation of a helper cell line for packaging avian leukosis virus-based vectors.
Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression.
Generation of destabilized herpes simplex virus type 1 thymidine kinase as transcription reporter for PET reporter systems in molecular genetic imaging.
Generation of fusion genes carrying drug resistance, green fluorescent protein, and herpes simplex virus thymidine kinase genes in a single cistron.
Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa.
Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutations.
Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence.
Genetic and physical evidence for the polarity of transcription of the thymidine kinase gene of herpes simplex virus.
Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients.
Genetic determinants of growth phase-dependent and adenovirus 5-responsive expression of the Chinese hamster thymidine kinase gene are contained within thymidine kinase mRNA sequences.
Genetic incorporation of a herpes simplex virus type 1 thymidine kinase and firefly luciferase fusion into the adenovirus protein IX for functional display on the virion.
Genetic incorporation of HSV-1 thymidine kinase into the adenovirus protein IX for functional display on the virion.
Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques.
Genetic rearrangements occurring during a single cycle of murine leukemia virus vector replication: characterization and implications.
Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility.
Genetically Engineered Multilineage-Differentiating Stress-Enduring Cells as Cellular Vehicles against Malignant Gliomas.
Genetically engineered suicide gene in mesenchymal stem cells using a Tet-On system for anaplastic thyroid cancer.
Genetically modified CD34+ cells exert a cytotoxic bystander effect on human endothelial and cancer cells.
Genetically Modified Donor Leukocyte Transfusion and Graft-Versus-Leukemia Effect After Allogeneic Stem Cell Transplantation.
Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice.
GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo.
Genome Editing of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells with Zinc Finger Nuclease for Cellular Imaging.
Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain.
Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals.
Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice.
Germline transmission of exogenous genes in the chicken.
GFAP Transgenic Mice
Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity.
Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells.
Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.
Glucocorticoid regulation of a transcription factor that binds an initiator-like element in the murine thymidine kinase (Tk-1) promoter.
Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice.
Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region.
Glucocorticoid repression of 3',5'-cyclic-adenosine monophosphate-dependent human corticotropin-releasing-hormone gene promoter activity in a transfected mouse anterior pituitary cell line.
Glucocorticoids enhance stability of human growth hormone mRNA.
Glucose-dependent insulinotropic polypeptide gene expression in the stomach: revealed by a transgenic mouse study, in situ hybridization and immunohistochemical staining.
Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment.
Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene.
Granulocyte-macrophage colony-stimulating factor in a combination gene therapy strategy for head and neck cancer.
Graphene oxide-hydroxyapatite nanocomposites effectively deliver HSV-TK suicide gene to inhibit human breast cancer growth.
HDAC inhibitor valproic acid enhances tumor cell kill in adenovirus-HSVtk mediated suicide gene therapy in HNSCC xenograft mouse model.
Heat-directed suicide gene therapy mediated by heat shock protein promoter for gastric cancer.
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Hemimethylation of DNA prevents chromatin expression.
Hepatoma cell-specific ganciclovir-mediated toxicity of a lentivirally transduced HSV-TkEGFP fusion protein gene placed under the control of rat alpha-fetoprotein gene regulatory sequences.
Hepatoma-specific gene therapy through retrovirus-mediated and targeted gene transfer using an adenovirus carrying the ecotropic receptor gene.
Herpes simplex thymidine kinase (HStk) transgenic donor lymphocytes.
Herpes simplex thymidine kinase gene transfer is required for complete regression of murine colon adenocarcinoma.
Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions.
Herpes simplex virus (type 1) thymidine kinase gene does not transform cells morphologically.
Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice.
Herpes simplex virus as a source of thymidine kinase for thymidine kinase-deficient mouse cells: suppression and reactivation of the viral enzyme.
Herpes simplex virus DNA polymerase, thymidine kinase and deoxyribonuclease activities in cells infected with wild type, ultraviolet-irradiated and defective virus.
Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus.
Herpes simplex virus thymidine kinase activity of thymidine kinase-deficient Escherichia coli K-12 mutant transformed by hybrid plasmids.
Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer.
Herpes simplex virus thymidine kinase and granulocyte macrophage colony-stimulating factor combination gene therapy in a murine CT26 cell colon cancer model.
Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
Herpes simplex virus thymidine kinase as a marker/reporter gene for PET imaging of gene therapy.
Herpes simplex virus thymidine kinase enzymatic assay in transient transfection experiments using thymidine kinase-deficient cells.
Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion.
Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation.
Herpes simplex virus thymidine kinase gene is stably maintained and expressed in cells transformed by protoplast fusion.
Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors.
Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.
Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells.
Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors.
Herpes simplex virus thymidine kinase imaging in mice with (1-(2'-deoxy-2'-[(18)F]fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil) and metabolite (1-(2'-deoxy-2'-[(18)F]fluoro-1-beta-D-arabinofuranosyl)-5-uracil).
Herpes simplex virus thymidine kinase mutations associated with resistance to acyclovir: a site-directed mutagenesis study.
Herpes simplex virus thymidine kinase transcripts are absent from both nucleus and cytoplasm during infection in the presence of cycloheximide.
Herpes simplex virus thymidine kinase-green fluorescent protein fusion gene: new tool for gene transfer studies and gene therapy.
Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound.
Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells.
Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells.
Herpes simplex virus thymidine kinase/ganciclovir-mediated killing of tumor cell induces tumor-specific cytotoxic T cells in mice.
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Herpes simplex virus type 1 thymidine kinase gene expression in Escherichia coli.
Herpes simplex virus type 1 thymidine kinase sequence fused to the lacz gene increases levels of {beta}-galactosidase activity per genome of high-capacity but not first-generation adenoviral vectors in vitro and in vivo.
Herpes simplex virus type 1 thymidine kinase-armed bovine herpesvirus type 4-based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models.
Herpes simplex virus type 1 UL46 and UL47 deletion mutants lack VP11 and VP12 or VP13 and VP14, respectively, and exhibit altered viral thymidine kinase expression.
Herpes simplex virus type 1 virion-derived US11 inhibits type 1 interferon-induced protein kinase R phosphorylation.
Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS.
Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis.
Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing.
Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines.
Herpes thymidine kinase mutants with altered catalytic efficiencies obtained by random sequence selection.
Herpesvirus saimiri pathogenicity enhanced by thymidine kinase of herpes simplex virus.
Herpesvirus thymidine kinase transgenes that do not cause male sterility are aberrantly transcribed and translated in the testis.
Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy.
High efficiency of replication and expression of foreign genes in SV40-transformed human fibroblasts.
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells.
High Mobility Group Box2 Promoter-controlled Suicide Gene Expression Enables Targeted Glioblastoma Treatment.
High mobility group proteins 1 and 2 function as general class II transcription factors.
High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector.
High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type 1 vector.
High-efficiency genome editing and allele replacement in prototrophic and wild strains of Saccharomyces.
High-frequency deletion in recovered retrovirus vectors containing exogenous DNA with promoters.
High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells.
High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant.
High-frequency transfer of cloned herpes simplex virus type 1 sequences to mammalian cells by protoplast fusion.
High-intensity focused ultrasound combined with herpes simplex virus thymidine kinase gene-loaded ultrasound-targeted microbubbles improved survival of rabbit with VX2 liver tumor.
High-level transgene expression mediated by the piggyBac transposon enhances transgenic therapeutic effects in cervical cancer xenografts.
Highly efficient and tumor-restricted gene transfer to malignant gliomas by replication-competent retroviral vectors.
Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes.
Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene.
Highly efficient gene transfer to solid tumors in vivo by tumor-selective replicating retrovirus vectors.
Highly efficient suicide gene expression in hepatocellular carcinoma cells by epstein-barr virus-based plasmid vectors combined with polyamidoamine dendrimer.
Highly potent transcriptional activation by 16-ene derivatives of 1,25-dihydroxyvitamin D3. Lack of modulation by 9-cis-retinoic acid of response to 1,25-dihydroxyvitamin D3 or its derivatives.
Highly reliable heterologous system for evaluating resistance of clinical herpes simplex virus isolates to nucleoside analogues.
Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
Highly-efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin.
Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer.
Homing and survival of thymidine kinase-transduced human T cells in NOD/SCID mice.
Homo-FRET microscopy in living cells to measure monomer-dimer transition of GFP-tagged proteins.
Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection.
Homologous recombination between overlapping thymidine kinase gene fragments stably inserted into a mouse cell genome.
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.
Homology requirement for efficient gene conversion between duplicated chromosomal sequences in mammalian cells.
Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir.
Hormonal induction of transfected genes depends on DNA topology.
Hormonally mediated negative regulation of human pro-opiomelanocortin gene expression after transfection into mouse L cells.
Host-specificities of papillomavirus, Moloney murine sarcoma virus and simian virus 40 enhancer sequences.
HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma.
HSV-1 Vectors for Gene Therapy of Experimental CNS Tumors.
HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells.
HSV-tk gene therapy for human renal cell carcinoma in nude mice.
HSV-tk gene therapy in head and neck squamous cell carcinoma. Enhancement by the local and distant bystander effect.
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia.
HSV-TK/IL-2 gene therapy for glioblastoma multiforme.
HSVtk/GCV system on hepatoma carcinoma cells: Construction of the plasmid pcDNA3.1?pAFP-TK and targeted killing effect.
Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes.
Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models.
Human beta-globin gene sequences injected into mouse eggs, retained in adults, and transmitted to progeny.
Human breast tumor cells express multimodal imaging reporter genes.
Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start site.
Human embryonic stem cell-derived cardiomyocyte therapy in mouse permanent ischemia and ischemia-reperfusion models.
Human Embryonic Stem Cell-Derived Endothelial Cells as Cellular Delivery Vehicles for Treatment of Metastatic Breast Cancer.
Human Embryonic Stem Cell-derived Mesenchymal Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma.
Human epithelial ovarian cancer xenotransplants into nude mice can be cured by adenovirus-mediated thymidine kinase gene therapy.
Human estrogen receptor introduced into the Xenopus oocyte represses expression from an artificial frog estrogen response element.
Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy.
Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice.
Human growth hormone as a reporter gene in regulation studies employing transient gene expression.
Human HLA-specific T-cell clones with stable expression of a suicide gene: a possible tool to drive and control a graft-versus-host- graft-versus-leukemia reaction?
Human insulin gene expression in transgenic mice: mutational analysis of the regulatory region.
Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy.
Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity.
Human NT2 Neural Precursor-Derived Tumor-Infiltrating Cells as Delivery Vehicles for Treatment of Glioblastoma.
Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression.
Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy.
Human reporter genes: potential use in clinical studies.
Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.
Human Wharton's jelly-derived mesenchymal stromal cells engineered to secrete Epstein-Barr virus interleukin-10 show enhanced immunosuppressive properties.
Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1.
Hybrid protein thymidine kinase gene fusions: plasmid vectors for the study of transcription and translation initiation signals.
Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes.
Hydroxyurea induces bystander cytotoxicity in cocultures of herpes simplex virus thymidine kinase-expressing and nonexpressing HeLa cells incubated with ganciclovir.
Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer.
Hypoxia/hepatoma dual specific suicide gene expression plasmid delivery using bio-reducible polymer for hepatocellular carcinoma therapy.
Identification and characterization of a novel transcriptional silencer in the human collagen type IV gene COL4A2.
Identification and characterization of an enhancer in the coding region of the genome of human immunodeficiency virus type 1.
Identification and characterization of the cis-elements regulating the rat AMOG (adhesion molecule on glia)/Na,K-ATPase beta 2 subunit gene.
Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the thymidine kinase and UL24 genes of herpes simplex virus type 1.
Identification and functional characterization of an erythroid-specific enhancer in the L-type pyruvate kinase gene.
Identification and functional characterization of glioma-specific promoters and their application in suicide gene therapy.
Identification and mapping of two polypeptides encoded within the herpes simplex virus type 1 thymidine kinase gene sequences.
Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase.
Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells.
Identification of a complex associated with processing and polyadenylation in vitro of herpes simplex virus type 1 thymidine kinase precursor RNA.
Identification of a glucocorticoid-responsive element in Epstein-Barr virus.
Identification of a high molecular weight steroid response element binding protein.
Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene.
Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus.
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.
Identification of a novel glucocorticoid receptor mutation in budesonide-resistant human bronchial epithelial cells.
Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain gene.
Identification of a placental-specific enhancer in the rat placental lactogen II gene that contains binding sites for members of the Ets and AP-1 (activator protein 1) families of transcription factors.
Identification of a silencing element in the chicken lipoprotein lipase gene promoter: characterization of the silencer-binding protein and delineation of its target nucleotide sequence.
Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene.
Identification of an estrogen-responsive element in the rat LH beta gene. DNA-estrogen receptor interactions and functional analysis.
Identification of DNA sequence responsible for 5-bromodeoxyuridine-induced gene amplification.
Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach.
Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.
Identification of glucocorticoid-responsive elements that control transcription of rat glutamine synthetase.
Identification of human genomic clones coding the major histocompatibility antigens HLA-a2 and HLA-B7 by DNA-mediated gene transfer.
Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.
Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: analysis of selected mutants in vitro.
Identification of NF1 as a silencer protein of the human adenine nucleotide translocase-2 gene.
Identification of sequences coding for thymidine kinase in herpes simplex virus and transformed cell DNA.
Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.
Identification of sequences involved in the transcriptional control of a Drosophila heat-shock gene.
Identification of the 12-O-tetradecanoylphorbol-13-acetate-responsive enhancer of the MS gene of the Epstein-Barr virus.
Identification of the herpes simplex virus DNA sequences present in six herpes simplex virus thymidine kinase-transformed mouse cell lines.
Identification of the thymidine kinase gene of infectious laryngotracheitis virus.
IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.
Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography.
Imaging Chemically Modified Adenovirus for Targeting Tumors Expressing Integrin {alpha}v{beta}3 in Living Mice with Mutant Herpes Simplex Virus Type 1 Thymidine Kinase PET Reporter Gene.
Imaging Gene Expression in Human Mesenchymal Stem Cells: From Small to Large Animals.
Imaging herpes viral thymidine kinase-1 reporter gene expression with a new 18F-labeled probe: 2'-fluoro-2'-deoxy-5-[18F]fluoroethyl-1-beta-d-arabinofuranosyl uracil.
Imaging in vivo herpes simplex virus thymidine kinase gene transfer to tumour-bearing rodents using positron emission tomography and.
Imaging methods in gene therapy of cancer.
Imaging Neural Stem Cell Graft-Induced Structural Repair in Stroke.
Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir.
Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography.
Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.
Imaging pulmonary gene expression with positron emission tomography.
Imaging the expression of transfected genes in vivo.
Imaging the spatial distribution of transgene expression in the lungs with positron emission tomography.
Imaging transgene expression with radionuclide imaging technologies.
Imaging tri-fusion multimodality reporter gene expression in living subjects.
Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells.
Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis.
Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2.
Immunization with live HPV-16-transformed mouse cells expressing the herpes simplex thymidine kinase and either GM-CSF or IL-2.
Immunogene approach toward cancer therapy using erythrocyte growth factor receptor-mediated gene delivery.
Immunogenicity versus pathogenicity after anterior chamber inoculation of an acyclovir-induced double mutant of HSV-1.
Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.
Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation.
Immunomodulation of glioma cells after gene therapy: induction of major histocompatibility complex class I but not class II antigen in vitro.
Immunosuppression promotes ocular virus replication and CNS neurovirulence following corneal inoculation with an avirulent herpes simplex type 1 thymidine kinase negative mutant.
Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy.
Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma.
Implication of in vivo circulating fibrocytes ablation in experimental pulmonary hypertension murine model.
Importance of C-terminus of herpes simplex virus type 1 thymidine kinase for maintaining thymidine kinase and acyclovir-phosphorylation activities.
Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice.
Improved gene expression by a modified bicistronic retroviral vector.
Improved gene expression by a U3-based retroviral vector.
Improved herpes simplex virus type 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic genes.
Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate.
Improved safety of a replication-competent poxvirus-based HIV vaccine with the introduction of the HSV-TK/GCV suicide gene system.
Improved therapeutic effect on malignant glioma with adenoviral suicide gene therapy combined with temozolomide.
Improvement of the dP-nucleoside-mediated herpes simplex virus thymidine kinase negative-selection system by manipulating dP metabolism genes.
Improving the safety of cell therapy with the TK-suicide gene.
In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial.
In situ gene therapy for prostate cancer.
In situ gene transfer and suicide gene therapy of gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine in dogs.
In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.
In situ polymerase chain reaction: localization of HSV-2 DNA sequences in infections of the nervous system.
In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery.
In situ use of suicide genes for cancer therapy.
In vitro activity of polyhydroxycarboxylates against herpesviruses and HIV.
In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma.
In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter.
In vitro and in vivo effects of retrovirus-mediated transfer of the connexin 43 gene in malignant gliomas: consequences for HSVtk/GCV anticancer gene therapy.
In vitro and in vivo evaluation of novel cationic liposomes utilized for cancer gene therapy.
In vitro evaluation of herpes simplex virus type 1 thymidine kinase reporter system in dynamic studies of transcriptional gene regulation.
In vitro evaluation of mutant HSV-1 thymidine kinases for suicide gene therapy.
In vitro model of suicide gene therapy for alpha-fetoprotein-producing gastric cancer.
In vitro selection of external guide sequences for directing RNase P-mediated inhibition of viral gene expression.
In vitro selection of RNase P ribozymes that efficiently cleave a target mRNA.
In vitro sensitization of the B16 murine melanoma cells to ganciclovir by different RNA and plasmid DNA constructions encoding HSVtk.
In vitro suppression of UAG and UGA mutants in the thymidine kinase gene of herpes simplex virus.
In vitro thymidine kinase/ganciclovir-based suicide gene therapy using replication defective herpes simplex virus-1 against leukemic B-cell malignancies (MCL, HCL, B-CLL).
In vitro transcription of the thymidine kinase gene of herpes simplex virus.
In vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine kinase gene.
In vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer.
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
In vivo and in vitro glioma cell killing induced by an adenovirus expressing both cytosine deaminase and thymidine kinase and its association with interferon-alpha.
In vivo antitumor effect of herpes simplex virus thymidine kinase gene therapy in rat hepatocellular carcinoma: feasibility of adenovirus-mediated intra-arterial gene delivery.
In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020: construction and evaluation in rodents.
In vivo characterization of a prostate-specific antigen promoter-based suicide gene therapy for the treatment of benign prostatic hyperplasia.
In vivo comparison of IVDU and IVFRU in HSV1-TK gene expressing tumor bearing rats.
In vivo demethylation of a MoMuLV retroviral vector expressing the herpes simplex thymidine kinase suicide gene by 5' azacytidine.
In vivo drug-selectable markers in gene therapy.
In vivo efficacy of HSV-TK transcriptionally targeted to the tumour vasculature is augmented by combination with cytotoxic chemotherapy.
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
In vivo gene delivery to tumor cells by transferrin-streptavidin-DNA conjugate.
In vivo gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration.
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors.
In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU.
In vivo Imaging of the Therapeutic Efficacy and Fate of Bimodal Engineered Stem Cells in Malignant Brain Tumors.
In vivo labeling of fission yeast DNA with thymidine and thymidine analogs.
In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus.
In vivo molecular imaging characterizes pulmonary gene expression during experimental lung transplantation.
In vivo molecular imaging of murine embryonic stem cells delivered to a burn wound surface via Integra® scaffolding.
In vivo reprogramming of human telomerase reverse transcriptase (hTERT) by trans-splicing ribozyme to target tumor cells.
In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model.
In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
In vivo surgical resection plus adjuvant gene therapy in the treatment of mammary and prostate cancer.
In vivo transfer of a foreign gene to keratinocytes using the hemagglutinating virus of Japan-liposome method.
In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors.
In-vitro synthesis of functional varicella zoster and herpes simplex viral thymidine kinase.
Incidence and distribution of herpes simplex virus types 1 and 2 from genital lesions in college women.
Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy.
Incorporation into nucleic acids of the antiherpes guanosine analog buciclovir, and effects on DNA and protein synthesis.
Increase in DNA vaccine efficacy by virosome delivery and co-expression of a cytolytic protein.
Increased bax expression is associated with cell death induced by ganciclovir in a herpes thymidine kinase gene-expressing glioma cell line.
Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells.
Increased efficiency of cisplatin-resistant cell lines to DNA-mediated gene transfer with cationic liposome.
Increased glioma growth in mice depleted of macrophages.
Indirect monitoring of endogenous gene expression by positron emission tomography (PET) imaging of reporter gene expression in transgenic mice.
Indirect Sertoli cell-mediated ablation of germ cells in mice expressing the inhibin-alpha promoter/herpes simplex virus thymidine kinase transgene.
Induced ablation of gonadotropins in transgenic mice expressing herpes simplex virus thymidine kinase under the FSH beta-subunit promoter.
Induced expression of the conditionally cytotoxic herpes simplex virus thymidine kinase gene by means of a parvoviral regulatory circuit.
Inducible Caspase9-mediated suicide gene for MSC-based cancer gene therapy.
Inducible expression of herpes simplex virus thymidine kinase from a bicistronic HIV1 vector.
Inducible expression of herpes simplex virus thymidine kinase increases sensitivity to ganciclovir but does not enhance bystander effect in breast cancer cells.
Inducible expression of suicide genes in Leishmania donovani amastigotes.
Inducible liver injury in the transgenic rat by expressing liver-specific suicide gene.
Induction capacity and influence of dThdMP on thymidine kinase activity of type 1 and 2 strains of herpes simplex virus.
Induction of a bystander effect in HeLa cells by using a bigenic vector carrying viral thymidine kinase and connexin32 genes.
Induction of cell death in activated hepatic stellate cells by targeted gene expression of the thymidine kinase/ganciclovir system.
Induction of deoxypyrimidine kinase activity in human embryonic lung cells infected with varicella-zoster virus.
Induction of human beta-interferon synthesis with poly(rI . rC) in mouse cells transfected with cloned cDNA plasmids.
Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.
Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Inflammatory thoughts about glioma gene therapy.
Influence of different promoters on the expression of tumor-necrosis-factor-alpha in ls174t human colon-carcinoma cells.
Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus types 1 and 2 and pseudorabies virus.
Influence of p53 status on the HSV-Tk/GCV-induced bystander effect in a panel of human ovarian carcinoma cell lines.
Influence of the bystander effect on HSV-tk/GCV gene therapy. A review.
Influence of the embryonic preplate on the organization of the cerebral cortex: a targeted ablation model.
Information transfer between duplicated chromosomal sequences in mammalian cells involves contiguous regions of DNA.
Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Inhibition by interferon of biochemical transformation induced by cloned herpesvirus thymidine kinase genes.
Inhibition by interferon of herpes simplex virus thymidine kinase and DNA polymerase in infected and biochemically transformed cells.
Inhibition of ATP-sensitive potassium channels increases HSV-tk/GCV bystander effect in U373 human glioma cells by enhancing gap junctional intercellular communication.
Inhibition of experimental proliferative vitreoretinopathy by retroviral vector-mediated transfer of suicide gene. Can proliferative vitreoretinopathy be a target of gene therapy?
Inhibition of gene expression by a short sense fragment.
Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter.
Inhibition of graft-versus-host disease. Use of a T cell-controlled suicide gene.
Inhibition of herpes simplex thymidine kinase gene expression by DNA methylation is an indirect effect.
Inhibition of herpes simplex virus reactivation by dipyridamole in a mouse model.
Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.
Inhibition of herpes simplex virus type 1 DNA polymerase by [1R(1 alpha,2 beta,3 alpha)]-9-[2,3-bis(hydroxymethyl)cyclobutyl] guanine.
Inhibition of HIV-1 multiplication in a human CD4+ lymphocytic cell line expressing antisense and sense RNA molecules containing HIV-1 packaging signal and Rev response element(s).
Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity.
Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo.
Inhibition of plasmid reporter gene expression in CHO cells by DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Inhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts.
Inhibition of promoter activity by methylation: possible involvement of protein mediators.
Inhibition of rat hepatocellular carcinoma tumor growth after multiple infusions of recombinant Ad.AFPtk followed by ganciclovir treatment.
Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease.
Inhibition of the herpes simplex virus thymidine kinase gene transfection in Ltk- cells by potential Z-DNA forming polymers.
Inhibition of the herpes simplex virus-coded thymidine kinase-complex by 9-beta-D-arabinofuranosyladenine 5'-monophosphate (ara-AMP) and 9-(2-hydroxyethoxymethyl)guanine-monophosphate (acyclo-GMP).
Inhibition of TNFalpha-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-kappaB- and MAPK-dependent mechanisms.
Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor.
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes.
Inhibition of tumor growth by direct intratumoral gene transfer of herpes simplex virus thymidine kinase gene with DNA-liposome complexes.
Inhibition of viral and cellular promoters by human wild-type p53.
Inhibition of viral gene expression by human ribonuclease P.
Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli.
Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo.
Inhibitory effect of cycloSaligenyl-nucleoside monophosphates (cycloSal-NMP) of acyclic nucleoside analogues on HSV-1 and EBV.
Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells.
Initiation of herpes simplex virus thymidine kinase polypeptides.
Initiator elements and regulated expression of the herpes simplex virus thymidine kinase gene.
Innovative strategies for the treatment of thyroid cancer.
Input of recombinant phenotyping for the characterization of a novel acyclovir-resistance mutation identified in a patient with recurrent herpetic keratitis.
Insertion and deletion mutants of vaccinia virus.
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.
Insertion of a new gene of viral origin into bone marrow cells of mice.
Insertion of new genes into bone marrow cells of mice.
Insertion sites for recombinant vaccinia virus construction: effects on expression of a foreign protein.
Insertional activation of a promoterless thymidine kinase gene.
INSM1 Promoter-Driven Adenoviral Herpes Simplex Virus Thymidine Kinase Cancer Gene Therapy for the Treatment of Primitive Neuroectodermal Tumors.
Insulin-induced reactivation of an inactive herpes simplex thymidine kinase gene.
Integrated homology modelling and X-ray study of herpes simplex virus I thymidine kinase: a case study.
Integration and expression of a truncated simian virus 40 early gene fragment in mammalian cells.
Integration site(s) of herpes simplex virus type 1 thymidine kinase gene and regional assignment of the gene for aminoacylase-1 in human chromosomes.
Integration-free iPS cells engineered using human artificial chromosome vectors.
Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates.
Interaction of cell and virus proteins with DNA sequences encompassing the promoter/regulatory and leader regions of the herpes simplex virus thymidine kinase gene.
Interaction of hepatitis B viral X protein and CCAAT/ enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter.
Interaction of the mouse chromosomal protein HMG-I with the 3' ends of genes in vitro.
Interaction of the recombinant herpes simplex virus type 1 thymidine kinase with thymidine and aciclovir: a kinetic study.
Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein, VP22.
Intercellular trafficking and cytotoxicity of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP repeat peptide.
Interdigitated deletion complexes on mouse chromosome 5 induced by irradiation of embryonic stem cells.
Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene.
Intracellular localization and sustained prodrug cell killing activity of TAT-HSVTK fusion protein in hepatocelullar carcinoma cells.
Intracellular localization of Herpes simplex virus type 1 thymidine kinase fused to different fluorescent proteins depends on choice of fluorescent tag.
Intracerebral Administration of Autologous Mesenchymal Stem Cells as HSV-TK Gene Vehicle for Treatment of Glioblastoma Multiform: Safety and Feasibility Assessment.
Intracerebral injection of adenovirus harboring the HSVtk gene combined with ganciclovir administration: toxicity study in nonhuman primates.
Intrachromosomal homologous recombination in human cells which differ in nucleotide excision-repair capacity.
Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response.
Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain.
Intratumoral activation of cyclophosphamide by retroviral transfer of the cytochrome P450 2B1 in a pancreatic tumor model. Combination with the HSVtk/GCV system.
Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy.
Introduction and expression of a fetal human globin gene in mouse fibroblasts.
Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker.
Introduction of cloned human papillomavirus 1a DNA into rat fibroblasts: integration, de novo methylation and absence of cellular morphological transformation.
Introduction of the herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA.
Introduction, rescue and expression of plasmid genes in mammalian cells and Escherichia coli.
Intron 16 insertion of the angiotensin converting enzyme gene and transcriptional regulation.
Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing.
Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone.
Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.
Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase.
Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo.
Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation.
Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells.
Iron Oxide Nanoparticles Promote Cx43-Overexpression of Mesenchymal Stem Cells for Efficient Suicide Gene Therapy during Glioma Treatment.
Iron(II) EDTA used to measure the helical twist along any DNA molecule.
Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.
Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors.
Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.
Isolation of a simian virus 40 T-antigen-positive, transformation-resistant cell line by indirect selection.
Isolation of cis-acting vaccinia virus DNA fragments promoting the expression of herpes simplex virus thymidine kinase by recombinant viruses.
Isolation of embryonal carcinoma cell lines that express integrated recombinant genes flanked by the Moloney murine leukemia virus long terminal repeat.
Isozyme studies on the association of the herpes simplex virus type 1 thymidine kinase gene with human chromosomes in somatic cell hybrids.
Killing effect of the herpes simplex virus thymidine kinase/ganciclovir enzyme/prodrug system on human nasopharyngeal carcinoma cells.
Killing Epstein-Barr virus-positive B lymphocytes by gene therapy: comparing the efficacy of cytosine deaminase and herpes simplex virus thymidine kinase.
Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme.
Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site.
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine.
Kinetics of cell death in T lymphocytes genetically modified with two novel suicide fusion genes.
Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2.
L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth.
Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation.
Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery.
Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms.
Lack of stereospecificity of suid pseudorabies virus thymidine kinase.
Large macromolecules can be introduced into cultured mammalian cells using erythrocyte membrane vesicles.
Latency-associated transcript but not reactivatable virus is present in sensory ganglion neurons after inoculation of thymidine kinase-negative mutants of herpes simplex virus type 1.
Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals.
Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains.
Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus.
Left-handedly curved DNA regulates accessibility to cis-DNA elements in chromatin.
Lentiviral vector conferring resistance to mycophenolate mofetil and sensitivity to ganciclovir for in vivo T-cell selection.
Lentiviral vector mediated thymidine kinase expression in pluripotent stem cells enables removal of tumorigenic cells.
Lentiviral vectors for T-cell suicide gene therapy: preservation of T-cell effector function after cytokine-mediated transduction.
Lepidopteran cell variants resistant to 5-bromodeoxyuridine and their use for transfection of the HSV-TK gene.
Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.
Limitations of retrovirus-mediated HSV-tk gene transfer to pulmonary adenocarcinoma cells in vitro and in vivo.
Linkage map of cotransfected viral DNA sequences in a mouse 3T3 cell line.
Linking a cell-division gene and a suicide gene to define and improve cell therapy safety.
Lipid-mediated protein delivery of suicide nucleoside kinases.
Liposomal delivery of the herpes simplex virus thymidine kinase gene in glioma: improvement of cell sensitization to ganciclovir.
Liposomal encapsulation of ganciclovir enhances the efficacy of herpes simplex virus type 1 thymidine kinase suicide gene therapy against hepatic tumors in rats.
Liposome vector containing biosurfactant-complexed DNA as herpes simplex virus thymidine kinase gene delivery system.
Liposome-mediated gene therapy using HSV-TK/ganciclovir under the control of human PSA promoter in prostate cancer cells.
Liquid-based iterative recombineering method tolerant to counter-selection escapes.
Live cell vaccines expressing B7.1, monocyte chemoattractant protein 1 and granulocyte-macrophage colony stimulation factor derived from mouse HPV16-transformed cells.
Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion.
Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase.
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Local inflammation and devascularization--in vivo mechanisms of the "bystander effect" in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma.
Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice.
Local regression of breast tumors following intramammary ganciclovir administration in double transgenic mice expressing neu oncogene and herpes simplex virus thymidine kinase.
Localization in mouse-L-Cell chromosomal sites of transferred immunoglobulin genes.
Localization of cis-acting sequences in the latency-related promoter of bovine herpesvirus 1 which are regulated by neuronal cell type factors and immediate-early genes.
Localization of the thymidine kinase gene of herpes simplex virus type 2 (333).
Localized adenovirus gene delivery using antiviral IgG complexation.
Locating a nucleotide-binding site in the thymidine kinase of vaccinia virus and of herpes simplex virus by scoring triply aligned protein sequences.
Location and cloning of the herpes simplex virus type 2 thymidine kinase gene.
Location of sequences in polyomavirus DNA that are required for early gene expression in vivo and in vitro.
Locoregional delivery of adenoviral vectors.
Long inverted repeats are an at-risk motif for recombination in mammalian cells.
Long term non-invasive imaging of embryonic stem cells using reporter genes.
Long-term connexin-mediated bystander effect in highly tumorigenic human cells in vivo in herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Long-term follow-up of patients with malignant pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy.
Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer.
Long-term rat survival after malignant brain tumor regression by retroviral gene therapy.
Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment.
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene.
Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses.
Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.
Longitudinal Characterization of Herpes Simplex Virus (HSV) Isolates Acquired From Different Sites in an Immune-Compromised Child: A New HSV Thymidine Kinase Mutation Associated With Resistance.
Loss of ganciclovir sensitivity by exclusion of thymidine kinase gene from transplanted proinsulin-producing fibroblasts as a gene therapy model for diabetes.
Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment.
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
Low p16(INK4a) Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone.
Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma.
Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase.
Luciferase assay to study the activity of a cloned promoter DNA fragment.
LY294002 Enhances Expression of Proteins Encoded by Recombinant Replication-Defective Adenoviruses via mTOR- and Non-mTOR-Dependent Mechanisms.
Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene.
Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells.
Mapping functional domains in the promoter region of the herpes thymidine kinase gene.
Mapping of herpes simplex virus-1 VP22 functional domains for inter- and subcellular protein targeting.
Mapping of the herpes simplex virus DNA sequences in three herpes simplex virus thymidine kinase-transformed cell lines.
Mapping of the late promoter of simian virus 40.
Mapping of the thymidine kinase genes of type 1 and type 2 herpes simplex viruses using intertypic recombinants.
Massive apoptotic cell death in chemically induced rat urinary bladder carcinomas following in situ HSVtk electrogene transfer.
Measuring herpes simplex virus thymidine kinase reporter gene expression in vitro.
Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment.
Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.
Mechanism of resistance to acyclovir in thymidine kinase mutants from Herpes simplex virus type 1: a computational approach.
Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex virus thymidine kinase gene.
Mechanisms in the transcriptional regulation of bradykinin B1 receptor gene expression. Identification of a minimum cell-type specific enhancer.
Mechanisms of glucocorticoid hormone action.
Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus.
Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging.
Metabolic fate of (E)-5-(2-bromovinyl)-2'-deoxyuridine in herpes simplex virus- and mock-infected cells.
Metabolic suicide genes in gene therapy.
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells.
Metastatic Ovarian Cancer Can Be Efficiently Treated by Genetically Modified Mesenchymal Stromal Cells.
Methodology and problems of protein-ligand docking: case study of dihydroorotate dehydrogenase, thymidine kinase, and phosphodiesterase 4.
Methylation in the preinitiation domain suppresses gene transcription by an indirect mechanism.
Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery.
MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene.
MicroPET imaging of prostate cancer in LNCAP-SR39TK-GFP mouse xenografts.
Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma.
Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter.
Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor.
Midkine promoter-based adenoviral vector gene delivery for pediatric solid tumors.
Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas.
Minicircles for a two-step blood biomarker and PET imaging early cancer detection strategy.
Minimal transcriptional enhancer of simian virus 40 is a 74-base-pair sequence that has interacting domains.
miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy.
miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy.
miR-145 is a potential biomarker for predicting clinical outcome in glioblastomas.
Misalignment-mediated DNA polymerase beta mutations: comparison of microsatellite and frame-shift error rates using a forward mutation assay.
Mitochondrial and herpesvirus-specific deoxypyrimidine kinases.
Mitochondrial DNA damage induces apoptosis in senescent cells.
Mitochondrial nucleic acids as internal standards for blot hybridization analyses.
MLH1 deficiency enhances tumor cell sensitivity to ganciclovir.
MLV/HIV-pseudotyped vectors: a new treatment option for cutaneous T cell lymphomas.
Mobilization of plasmid pHSV106 from Escherichia coli HB101 in a laboratory-scale waste treatment facility.
Mobilization of the genetically engineered plasmid pHSV106 from Escherichia coli HB101(pHSV106) to Enterobacter cloacae in drinking water.
Mode of cell death associated with adenovirus-mediated suicide gene therapy in HNSCC tumor model.
Modular structure of the beta-globin and the TK promoters.
Modulation of transfected gene expression mediated by changes in chromatin structure.
Molecular ablation of tumor blood vessels inhibits therapeutic effects of radiation and bevacizumab.
Molecular analysis of a neurovirulent herpes simplex virus type 2 strain with reduced thymidine kinase activity.
Molecular analysis of chromosome-mediated gene transfer.
Molecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea.
Molecular analysis of the human myeloperoxidase promoter region.
Molecular approaches to chemo-radiotherapy.
Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides.
Molecular characterization of a novel transcription factor that controls stromelysin expression.
Molecular diagnosis and gene therapy in musculoskeletal tumors.
Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy.
Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography.
Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation.
Molecular imaging of homodimeric protein-protein interactions in living subjects.
Molecular imaging of human embryonic stem cells.
Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo.
Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence.
Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer.
Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene.
Molecular modeling of the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.
Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU.
Molecular-genetic PET imaging using an HSV1-tk mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs.
Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene.
Monitoring Bone Marrow Stem Cells with a Reporter Gene System in Experimental Middle Cerebral Artery Occlusion Rat Models.
Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: uptake of specific substrates.
Monitoring gene therapy with reporter gene imaging.
Monitoring HSV-TK/ganciclovir cancer suicide gene therapy using CdTe/CdS core/shell quantum dots.
Monitoring of bystander effect of herpes simplex virus thymidine kinase/acyclovir system using fluorescence resonance energy transfer technique.
Monitoring of developing graft-versus-host disease mediated by herpes simplex virus thymidine kinase gene-transduced T cells.
Monitoring of gliomas in vivo by diffusion MRI and (1)H MRS during gene therapy-induced apoptosis: interrelationships between water diffusion and mobile lipids.
Monitoring of herpes simplex virus thymidine kinase enzyme activity using positron emission tomography.
Monitoring the Bystander Killing Effect of Human Multipotent Stem Cells for Treatment of Malignant Brain Tumors.
Monitoring the efficacy of adoptively transferred prostate cancer-targeted human T lymphocytes with PET and bioluminescence imaging.
Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging.
Monoclonal antibodies to herpes simplex virus thymidine kinase.
Morphological transformation by DNA fragments of human herpesviruses: evidence for two distinct transforming regions in herpes simplex virus types 1 and 2 and lack of correlation with biochemical transfer of the thymidine kinase gene.
Mouse L cells express a molecular complex carrying the human epitopes recognized by monoclonal antibodies 44D7 and 44H7 after DNA-mediated gene transfer.
Mouse mammary tumor virus mediated transfer and expression of neomycin resistance to infected cultured cells.
Mouse model for ablation of proliferating microglia in acute CNS injuries.
MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma.
Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells.
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies.
Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging.
Multimodality molecular imaging to monitor transplanted stem cells for the treatment of ischemic heart disease.
Multiple regulatory elements in the intergenic region between the alpha-fetoprotein and albumin genes.
Multiple sequence elements are involved in RNA 3' end formation in spleen necrosis virus.
Multiple sets of adjacent mu E1 and oct-1 binding sites upstream of the pseudorabies virus immediate-early gene promoter.
Multiple transduction as a means of preserving ganciclovir chemosensitivity in sarcoma cells carrying retrovirally transduced herpes thymidine kinase genes.
Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector.
Multitracer studies during gene therapy of hepatoma cells with herpes simplex virus thymidine kinase and ganciclovir.
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Muscle-specific activity of the skeletal troponin I promoter requires interaction between upstream regulatory sequences and elements contained within the first transcribed exon.
Mutant of herpes simplex virus type 1 conditionally able to transform thymidine kinaseless L cells to a tk+ phenotype.
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies.
Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells.
Mutation spectra of herpes simplex virus type 1 thymidine kinase mutants.
Mutational analyses of dinucleotide and tetranucleotide microsatellites in Escherichia coli: influence of sequence on expansion mutagenesis.
Mutational specificities of 1'-acetoxysafrole, N-benzoyloxy-N-methyl-4-aminoazobenzene, and ethyl methanesulfonate in human cells.
Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.
Myocardial kinetics of reporter probe 124I-FIAU in isolated perfused rat hearts after in vivo adenoviral transfer of herpes simplex virus type 1 thymidine kinase reporter gene.
N-ethyl-N-nitrosourea induces A:T to C:G transversion mutations as well as transition mutations in SOS-induced Escherichia coli.
N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.
Negative selection of herpes simplex virus thymidine kinase in Toxoplasma gondii.
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination.
Negative selection using thymidine kinase increases the efficiency of recovery of transformants with targeted genes in the filamentous fungus Leptosphaeria maculans.
Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity.
Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models.
NeoR-based transduced T lymphocytes detected by real-time quantitative polymerase chain reaction.
Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA.
Neural stem cell-based dual suicide gene delivery for metastatic brain tumors.
Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.
Neurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat).
Neurovirulence and latency of drug-resistant clinical herpes simplex viruses in animal models.
Neurovirulence of an herpes simplex type 1 thymidine kinase negative mutant determined by virus biochemical defect and host immune system in mice. Brief report.
Neurovirulence of herpes simplex virus type 1 depends on age in mice and thymidine kinase expression.
New culture technique of human eliminable feeder-assisted target cell sheet production.
New Plasmids for Fusarium Transformation Allowing Positive-Negative Selection and Efficient Cre-loxP Mediated Marker Recycling.
New positive/negative selectable markers for mammalian cells on the basis of Blasticidin deaminase-thymidine kinase fusions.
New vectors for simplified construction of BrdU-Incorporating strains of Saccharomyces cerevisiae.
NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression.
NF-kappa B regulates BCL3 transcription in T lymphocytes through an intronic enhancer.
Non myeloablative "mini transplants".
Non-integrating lentiviral vectors for specific killing of Epstein-Barr virus nuclear antigen 1-positive B cell lymphoma cells.
Non-invasive imaging of cardiac transgene expression with PET: comparison of the human sodium/iodide symporter gene and HSV1-tk as the reporter gene.
Non-invasive imaging of reporter genes.
Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir.
Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy model.
Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.
Non-Small-Cell Lung Cancer: Feasibility of Intratumoral Radiofrequency Hyperthermia-enhanced Herpes Simplex Virus Thymidine Kinase Gene Therapy.
Non-traumatic acquisition of herpes simplex virus infection through the eye.
Noninvasive and Local Delivery of Adenoviral-Mediated Herpes Simplex Virus Thymidine Kinase to Treat Glioma Through Focused Ultrasound-Induced Blood-Brain Barrier Opening in Rats.
Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma.
Noninvasive imaging of cationic lipid-mediated delivery of optical and PET reporter genes in living mice.
Noninvasive imaging of ex vivo intracoronarily delivered nonviral therapeutic transgene expression in heart.
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.
Noninvasive imaging of protein-protein interactions in living animals.
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers.
Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus.
Nonmyeloablative immunosuppressive regimen prolongs In vivo persistence of gene-modified autologous T cells in a nonhuman primate model.
Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies.
Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells.
Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma.
Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
Novel 6-azapyrimidine-2'-deoxy-4'-thionucleosides: synthesis, biological evaluation and conformational analysis.
Novel codon utilization within the vaccinia virus thymidine kinase gene.
Novel estrogenic action of the pesticide residue beta-hexachlorocyclohexane in human breast cancer cells.
Novel hepatitis B virus infection mouse model using herpes simplex virus type 1 thymidine kinase transgenic mice.
Novel infectivity-enhanced oncolytic adenovirus with a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancer.
Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient.
Novel radiosynthesis of PET HSV-tk gene reporter probes [18F]FHPG and [18F]FHBG employing dual Sep-Pak SPE techniques.
Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2.
Novel retroviral vector transferring a suicide gene and a selectable marker gene with enhanced gene expression by using a tetracycline-responsive expression system.
Novel use of synthetic oligonucleotide insertion mutants for the study of homologous recombination in mammalian cells.
Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?
Nuclease footprint analyses of the interactions between RNase P ribozyme and a model mRNA substrate.
Nucleoside analogs as non-substrate inhibitors of herpes simplex viruses thymidine kinase.
Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.
Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.
Nucleosomal packaging of the thymidine kinase gene of herpes simplex virus transferred into mouse cells: an actively expressed single-copy gene.
Nucleotide sequence changes in thymidine kinase gene of herpes simplex virus type 2 clones from an isolate of a patient treated with acyclovir.
Nucleotide sequence of the herpes simplex virus type 2 (HSV-2) thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thymidine kinase gene.
Nucleotide sequence of the herpes simplex virus type 2 thymidine kinase gene.
Nucleotide sequence of the thymidine kinase gene of a new strain of herpes simplex virus type 1.
Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.
Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus.
Nucleotide sequence requirements for transient expression of human metallothionein-IIA-thymidine kinase fusion genes.
Nucleotide sequences responsible for the thermal inducibility of the Drosophila small heat-shock protein genes in monkey COS cells.
O6-methylguanine induces intrachromosomal homologous recombination in human cells.
Occurrence of antibodies against herpes simplex virus thymidine kinase in human sera.
Ocular gene therapy: experimental studies and clinical possibilities.
Oligonucleotide-directed mutagenesis and subsequent expression of the corresponding recombinant proteins without changing the bacterial vector system.
Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.
Oncolytic Gene Therapy Combined with Double Suicide Genes for Human Bile Duct Cancer in Nude Mouse Models.
Oncoselective parvoviral vector-mediated gene therapy of cancer.
One-Stage Positron Emission Tomography and Magnetic Resonance Imaging to Assess Mesenchymal Stem Cell Survival in a Canine Model of Intervertebral Disc Degeneration.
Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element.
Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice.
Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.
Optimized assay for thymidine kinase and its application to the detection of antibodies against herpes simplex virus type 1- and 2-induced thymidine kinase.
Optimizing fluorescent protein expression for quantitative fluorescence microscopy and spectroscopy using herpes simplex thymidine kinase promoter sequences.
Optimizing prostate cancer suicide gene therapy using herpes simplex virus thymidine kinase active site variants.
Optimizing suicide gene therapy for head and neck cancer.
Organized Neurogenic-Niche-Like Pinwheel Structures Discovered in Spinal Cord Tissue-Derived Neurospheres.
Origins of Suicide Gene Therapy.
Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models.
Osteonectin Promoter-Mediated Suicide Gene Therapy of Prostate Cancer.
Osteosarcoma and chondrosarcoma as targets for virus vectors and herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Ovalbumin is synthesized in mouse cells transformed with the natural chicken ovalbumin gene.
Ovarian Cancer Gene Therapy Using HPV-16 Pseudovirion Carrying the HSV-tk Gene.
Ovarian cancer gene therapy: repeated treatment with thymidine kinase in an adenovirus vector and ganciclovir improves survival in a novel immunocompetent murine model.
Ovarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element.
Overexpression of a heterologous thymidine kinase delays apoptosis induced by factor deprivation and inhibitors of deoxynucleotide metabolism.
Overexpression of c-fos increases recombination frequency in human osteosarcoma cells.
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Overproduction of the protein product of a nonselected foreign gene carried by an adenovirus vector.
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
P21-driven multifusion gene system for evaluating the efficacy of histone deacetylase inhibitors by in vivo molecular imaging and for transcription targeting therapy of cancer mediated by histone deacetylase inhibitor.
P53-dependent cell-killing by selective repression of thymidine kinase and reduced prodrug activation.
Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene.
Papers to appear in forthcoming issues
Partial regression, yet incomplete eradication of mammary tumors in transgenic mice by retrovirally mediated HSVtk transfer 'in vivo'.
Partial substitution of the functions of the herpes simplex virus 1 U(L)13 gene by the human cytomegalovirus U(L)97 gene.
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules.
Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signals.
PEG-PBLG nanoparticle-mediated HSV-TK/GCV gene therapy for oral squamous cell carcinoma.
Penciclovir is a potent inhibitor of feline herpesvirus-1 with susceptibility determined at the level of virus-encoded thymidine kinase.
Percutaneous gene therapy using recombinant adenoviruses encoding human herpes simplex virus thymidine kinase, human PAI-1, and human NOS3 in balloon-injured porcine coronary arteries.
Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis [corrected]
Persistent herpes simplex virus infection and mechanisms of virus drug resistance.
PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts.
PET imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk reporter gene expression in mice and humans using [18F]FHBG.
PET imaging of HSV1-tk mutants with acquired specificity toward pyrimidine- and acycloguanosine-based radiotracers.
PET Imaging of Oncolytic VSV Expressing the Mutant HSV-1 Thymidine Kinase Transgene in a Preclinical HCC Rat Model.
PET of cardiac transgene expression: comparison of 2 approaches based on herpesviral thymidine kinase reporter gene.
PET reporter gene imaging and ganciclovir-mediated ablation of chimeric antigen receptor T-cells in solid tumors.
Phage particle-mediated gene transfer to cultured mammalian cells.
Pharmacokinetic considerations regarding non-viral cancer gene therapy.
Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs.
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside.
Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors.
Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer.
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer.
Phase IB Study of Gene-Mediated Cytotoxic Immunotherapy Adjuvant to Up-Front Surgery and Intensive Timing Radiation for Malignant Glioma.
Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir.
Phenotypic switching in cells transformed with the herpes simplex virus thymidine kinase gene.
Phenotypic variation associated with molecular alterations at a cluster of thymidine kinase genes.
Phosphorylation and cytotoxicity of therapeutic nucleoside analogues: a comparison of alpha and gamma herpesvirus thymidine kinase suicide genes.
Phosphorylation of 5-iodo-5'-amino-2',5',dideoxyuridine by herpes simplex virus type 1 encoded thymidine kinase.
Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase.
Phosphorylation of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes viruses.
Phosphorylation of the enantiomers of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase.
Photochemically enhanced gene transfection increases the cytotoxicity of the herpes simplex virus thymidine kinase gene combined with ganciclovir.
Picosecond-hetero-FRET microscopy to probe protein-protein interactions in live cells.
Pituitary and ovarian expression of the endogenous follicle-stimulating hormone (FSH) subunit genes and an FSH beta-subunit promoter-driven herpes simplex virus thymidine kinase gene in transgenic mice; specific partial ablation of FSH-producing cells by antiherpes treatment.
Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates.
Plasma and CSF pharmacokinetics of ganciclovir in nonhuman primates.
Plasmid DNA mediated transfer of the herpes simplex virus thymidine kinase gene to a new bromodeoxyuridine resistant variant of human primary lung carcinoma cells.
Plasmid rescue - a tool for reproducible recovery of genes from transfected mammalian cells?
Plasmidial maintenance in rodent fibroblasts of a BPV1-pBR322 shuttle vector without immediately apparent oncogenic transformation of the recipient cells.
Plasmids containing mouse rDNA do not recombine with cellular ribosomal genes when introduced into cultured mouse cells.
Plasmids expressing the Herpes simplex virus thymidine kinase gene in mammalian and bacterial cells.
Platelet-derived growth factor A-chain gene transcription is mediated by positive and negative regulatory regions in the promoter.
Pleiotropic expression of heterologous cytokine/receptor genes in HTLV-1 associated diseases: candidate TRS for chimeric gene therapy.
PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins.
Polyadenylation of the Xenopus beta 1 globin mRNA at a downstream minor site in the absence of the major site and utilization of an AAUACA polyadenylation signal.
Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.
Polyamine depletion and cell cycle manipulation in combination with HSV thymidine kinase/ganciclovir cancer gene therapy.
Polyethylenimine-mediated suicide gene transfer induces a therapeutic effect for hepatocellular carcinoma in vivo by using an Epstein-Barr virus-based plasmid vector.
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.
Polymeric Nanovectors Incorporated with Ganciclovir and HSV-tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy.
Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: analysis of clinical isolates from herpetic keratitis patients and laboratory strains.
Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences.
Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK.
Positron emission tomography imaging of cardiac reporter gene expression in living rats.
Positron emission tomography imaging of conditional gene activation in the heart.
Positron emission tomography of herpes simplex virus 1 oncolysis.
Positron emission tomography: measurement of transgene expression.
Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas.
Positron-emission tomography reporter gene expression imaging in rat myocardium.
Possible peptide chain termination mutants in thymide kinase gene of a mammalian virus, herpes simplex virus.
Possible roles of the 3'-flanking sequences of the human activin beta A subunit gene in its expression.
Post-translational regulation of gene expression using the ATF4 oxygen-dependent degradation domain for hypoxia-specific gene therapy.
Potent anti-tumor activity of telomerase-dependent and HSV-TK armed oncolytic adenovirus for non-small cell lung cancer in vitro and in vivo.
Potent bystander effect in suicide gene therapy using neural stem cells transduced with herpes simplex virus thymidine kinase gene.
Potent tumor-specific immunity induced by an in vivo heat shock protein-suicide gene-based tumor vaccine.
Potential of gene therapy for the treatment of pituitary tumors.
Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin.
Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy.
Pre-mRNA processing enhancer (PPE) elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes.
Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma.
Preclinical and therapeutic utility of HVJ liposomes as a gene transfer vector for hepatocellular carcinoma using herpes simplex virus thymidine kinase.
Preclinical evaluation of the penciclovir analog 9-(4-[(18)F]fluoro-3-hydroxymethylbutyl)guanine for in vivo measurement of suicide gene expression with PET.
Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells.
Preclinical Safety Evaluation of 18F-FHBG: A PET Reporter Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase (HSV1-tk) or Mutant HSV1-sr39tk's Expression.
Prediction of the binding mode of N2-phenylguanine derivative inhibitors to herpes simplex virus type 1 thymidine kinase.
Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine.
Preferential gene transfer to BBN-induced rat bladder tumor by simple instillation of adenoviral vector.
Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir.
Preliminary in vitro efficacy and toxicities studies of the herpes simplex thymidine kinase gene system for the treatment of breast cancer.
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.
Prenatal exposure to thyroid hormone is necessary for normal postnatal development of murine heart and lungs.
Preparation and biological evaluation of 2-amino-6-[18F]fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-[18F]FPCV) as a novel PET probe for imaging HSV1-tk reporter gene expression.
Preparation of a "functional library" of African green monkey DNA fragments which substitute for the processing/polyadenylation signal in the herpes simplex virus type 1 thymidine kinase gene.
Presence of antibody against herpes simplex virus-specified thymidine kinase and deoxyribonuclease in human sera.
Presence of transcription regulatory elements within an intron of the virus-inducible murine TIMP gene.
Preservation of the bystander cytocidal effect of irradiated herpes simplex virus thymidine kinase (HSV-tk) modified tumor cells.
Prevention of graft-versus-host disease in mice using a suicide gene expressed in T lymphocytes.
Prevention of hepatitis C virus infection by adoptive allogeneic immunotherapy using suicide gene-modified lymphocytes: an in vitro proof-of-concept.
Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.
Procaspase-3 enhances the in vitro effect of cytosine deaminase-thymidine kinase disuicide gene therapy on human ovarian cancer.
Processing of herpes simplex virus proteins and evidence that translation of thymidine kinase mRNA is initiated at three separate AUG codons.
Prodrug activation gene therapy and external beam irradiation in the treatment of prostate cancer.
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Prodrug-activated gene therapy: involvement of an immunological component in the "bystander effect".
Prodrugs in genetic chemoradiotherapy.
Prodrugs of herpes simplex thymidine kinase inhibitors.
Production and characterization of a bicistronic Moloney-based retroviral vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for gene therapy of cancer.
Production and culture of HSVtk transduced suicidal lymphocytes induces variable changes in the lymphocyte subset composition.
Production and first-in-man use of T cells engineered to express a HSVTK-CD34 sort-suicide gene.
Production of a heterozygous mutant cell line by homologous recombination (single knockout).
Production of a T-antigen-related protein in mammalian cells after stable transformation with a cloned SV40 gene fragment.
Production of herpes simplex virus type 1 thymidine kinase in the presence of thymidine analogues.
Production of human glucocerebrosidase in mice after retroviral gene transfer into multipotential hematopoietic progenitor cells.
Prognostic utility of gene therapy with herpes simplex virus thymidine kinase for patients with high-grade malignant gliomas: a systematic review and meta analysis.
Progress report on phase I/II clinical trial of Ad-OC-TK plus VAL therapy for metastatic or locally recurrent prostate cancer: Initial experience at Kobe University.
Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
Prolactin and growth hormone stimulation of lactation in mice requires thyroid hormones.
Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes.
Promoter-glutathione S-transferase Ya cDNA hybrid genes. Expression and conferred resistance to an alkylating molecule in mammalian cells.
Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines.
Properties of a novel thymidine kinase induced by an acyclovir-resistant herpes simplex virus type 1 mutant.
Properties of Cells Carrying the Herpes Simplex Virus Type 2 Thymidine Kinase Gene: Mechanisms of Reversion to a Thymidine Kinase-Negative Phenotype.
Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase.
ProPose: steered virtual screening by simultaneous protein-ligand docking and ligand-ligand alignment.
Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models.
Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model.
Protecting against wayward human induced pluripotent stem cells with a suicide gene.
Protection against Leishmania major challenge infection in mice vaccinated with live recombinant parasites expressing a cytotoxic gene.
Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: the Good Samaritan effect.
Proteins containing only half of the coding information of early region 1b of adenovirus are functional in human cells transformed with the herpes simplex virus type 1 thymidine kinase gene and adenovirus type 2 DNA.
Proteolytic mapping of the thymidine/thymidylate binding site of herpes simplex virus type 1 thymidine kinase: a general photoaffinity labeling method for identifying active-site peptides.
Pseudotyped retrovectors for tumor-specific delivery of toxic suicide genes.
Psi- vectors: murine leukemia virus-based self-inactivating and self-activating retroviral vectors.
Purification and characterization of herpes simplex virus (type 1) thymidine kinase produced in Escherichia coli by a high efficiency expression plasmid utilizing a lambda PL promoter and cI857 temperature-sensitive repressor.
Purification and crystallization of thymidine kinase from herpes simplex virus type 1.
Purification and photoaffinity labeling of herpes simplex virus type-1 thymidine kinase.
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms.
Purified herpes simplex virus thymidine kinase retroviral particles: III. Characterization of bystander killing mechanisms in transfected tumor cells.
Pyrimidine acyclic nucleosides, 1-[(2-Hydroxyethoxy)methyl]pyrimidines as candidate antivirals.
Pyrimidine acyclic nucleosides. 5-Substituted 1-[(2-aminoethoxy)methyl]uracils as candidate antivirals.
QSAR and molecular graphics analysis of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
QSAR of N2-phenylguanidines as inhibitors of herpes simplex virus-1 thymidine kinase.
Quantification and Analysis of Thymidine Kinase Expression from Acyclovir-Resistant G-String Insertion and Deletion Mutants in Herpes Simplex Virus-Infected Cells.
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus.
Quantitation of cell number by a positron emission tomography reporter gene strategy.
Quantitation of pulmonary transgene expression with PET imaging.
Quantitative 1H nuclear magnetic resonance diffusion spectroscopy of BT4C rat glioma during thymidine kinase-mediated gene therapy in vivo: identification of apoptotic response.
Quantitative analysis of clinically relevant mutations occurring in lymphoid cells harboring gamma-retrovirus-encoded hsvtk suicide genes.
Quantitative analysis of gene suppression in integrated retrovirus vectors.
Quantitative kinetics of [124I]FIAU in cat and man.
Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen.
Rabbit beta-globin mRNA production in mouse L cells transformed with cloned rabbit beta-globin chromosomal DNA.
Radiochemotherapy of hepatocarcinoma via lentivirus-mediated transfer of human sodium iodide symporter gene and herpes simplex virus thymidine kinase gene.
Radiolabeled antiviral drugs and antibodies as virus-specific imaging probes.
Radiopharmaceuticals to monitor gene transfer.
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Radiosensitization of human glioma cells in vitro and in vivo with acyclovir and mutant HSV-TK75 expressed from adenovirus.
Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion.
Rapid and liquid-based selection of genetic switches using nucleoside kinase fused with aminoglycoside phosphotransferase.
Rapid and reproducible radiosynthesis of [18F] FHBG.
Rapid phenotypic characterization method for herpes simplex virus and Varicella-Zoster virus thymidine kinases to screen for acyclovir-resistant viral infection.
Rapid Regulation of Human Mesenchymal Stem Cell Proliferation Using Inducible Caspase-9 Suicide Gene for Safe Cell-Based Therapy.
Rapid selection of antigen-specific T lymphocytes by retroviral transduction.
Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development.
Rapid typing of herpes simplex virus based on immunological specificity of viral thymidine kinase and typing according to sensitivity to iododeoxyuridine.
Rat adenocarcinoma cell line infected with an adenovirus carrying a novel herpes-simplex virus-thymidine kinase suicide gene construct dies by apoptosis upon treatment with ganciclovir.
Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment.
Rational design of a triple reporter gene for multimodality molecular imaging.
Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 Gs homopolymer repeat of the thymidine kinase gene.
Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside.
Real-time visualizing and tracing of HSV-TK/GCV suicide gene therapy by near-infrared fluorescent quantum dots.
Rearrangements of microinjected recombinant DNA in the genome of transgenic mice.
recA-dependent and recA-independent N-ethyl-N-nitrosourea mutagenesis at a plasmid-encoded herpes simplex virus thymidine kinase gene in Escherichia coli.
Recent advances in experimental molecular therapeutics for malignant gliomas.
Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects: applications to breast cancer.
Receptor-mediated gene delivery using the Fab fragments of anti-epidermal growth factor receptor antibodies: improved immunogene approach.
Recognition by xenogeneic cytotoxic T lymphocytes of cells expressing HLA-A2 or HLA-B7 after DNA-mediated gene transfer.
Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility.
Recombinant interferon alpha2a synergistically enhances ganciclovir-mediated tumor cell killing in the herpes simplex virus thymidine kinase system.
Recombination during gene transfer into mouse cells can restore the function of deleted genes.
Recombination events in Neurospora crassa may cross a translocation breakpoint by a template-switching mechanism.
Recovery of a hybrid vector, derived from bovine papilloma virus DNA, pBR322 and the HSV tk gene, by bacterial transformation with extrachromosomal DNA from transfected rodent cells.
Recovery of a latent HSV-1 thymidine kinase negative strain following iontophoresis and co-cultivation in the ocularly-infected rabbit model.
Recovery of myelin after induction of oligodendrocyte cell death in postnatal brain.
Recovery of recombinant bacterial plasmids from E. coli transformed with DNA from microinjected mouse cells.
Rectal immunization generates protective immunity in the female genital tract against herpes simplex virus type 2 infection: Relative importance of myeloid differentiation factor 88.
Recurrent aciclovir-resistant herpes simplex in a child with Wiskott-Aldrich syndrome.
Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis?
Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene.
Reduced graft-versus-host disease-inducing capacity of T cells after activation, culturing, and magnetic cell sorting selection in an allogeneic bone marrow transplantation model in rats.
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.
Refined human artificial chromosome vectors for gene therapy and animal transgenesis.
Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.
Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
Regulated expression of a transfected human cardiac actin gene during differentiation of multipotential murine embryonal carcinoma cells.
Regulated expression of stably transfected herpes simplex virus thymidine kinase genes in continuous cell lines expressing a temperature-sensitive mutant form of the immediate-early protein ICP4.
Regulated expression of the human beta-globin gene family in murine erythroleukaemia cells.
Regulated high-level expression of the Herpes simplex type I thymidine kinase gene in Escherichia coli.
Regulated Mesenchymal Stem Cells Mediated Colon Cancer Therapy Assessed by Reporter Gene Based Optical Imaging.
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters.
Regulation of cellular genes transduced by herpes simplex virus.
Regulation of function of the murine luteinizing hormone receptor promoter by cis- and trans-acting elements in mouse Leydig tumor cells.
Regulation of herpes simplex virus 1 genes: alpha gene sequence requirements for transient induction of indicator genes regulated by beta or late (gamma 2) promoters.
Regulation of herpes simplex virus thymidine kinase in cells treated with a synergistic antiviral combination of alpha interferon and acyclovir.
Regulation of herpes simplex virus type 1 thymidine kinase gene expression by thyroid hormone receptor in cultured neuronal cells.
Regulation of herpes simplex virus-induced thymidine kinase.
Regulation of herpesvirus thymidine kinase activity in LM(TK) cells transformed by ultraviolet light-irradiated herpes simplex virus.
Regulation of HSVtk gene by endogenous microRNA-122a in liver cell lines as suicide gene therapy.
Regulation of indoleamine 2,3-dioxygenase gene expression in human fibroblasts by interferon-gamma. Upstream control region discriminates between interferon-gamma and interferon-alpha.
Regulation of neighboring gene expression by the herpes simplex virus type 1 thymidine kinase gene.
Regulation of proliferation and functioning of transplanted cells by using herpes simplex virus thymidine kinase gene in mice.
Regulation of recombinant human granulocyte colony-stimulation factor production using herpes simplex virus 1 thymidine kinase gene.
Regulation of the herpes simplex virus gene for thymidine kinase in clonal derivatives of transformed mouse L-cells.
Regulation of the murine alpha B-crystallin/small heat shock protein gene in cardiac muscle.
Regulation of the neural-specific gene VGF in PC12 cells. Identification of transcription factors interacting with NGF-responsive elements.
Regulation of type II renal Na+-dependent inorganic phosphate transporters by 1,25-dihydroxyvitamin D3. Identification of a vitamin D-responsive element in the human NAPi-3 gene.
Regulation of tyrosinase expression and activity in cultured human retinal pigment epithelial cells.
Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines.
Release of the p53-induced repression on thymidine kinase promoter by single p53-binding sequence.
Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains.
Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy.
Remnant living cells that escape cell loss in late-stage tumors exhibit cancer stem cell-like characteristics.
Repair of a specific double-strand break generated within a mammalian chromosome by yeast endonuclease I-SceI.
Repetitive imaging of reporter gene expression in the lung.
Repetitive noninvasive monitoring of HSV1-tk-expressing T cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography with 18F-FEAU.
Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy.
Replication and expression of thymidine kinase and human globin genes microinjected into mouse fibroblasts.
Replication and virulence of pseudorabies virus mutants lacking glycoprotein gX.
Replication fidelity of the supF gene integrated in the thymidine kinase locus of herpes simplex virus type 1.
Replication inhibition by nucleoside analogues of a recombinant Autographa californica multicapsid nuclear polyhedrosis virus harboring the herpes thymidine kinase gene driven by the IE-1(0) promoter: a new way to select recombinant baculoviruses.
Replication of HSV-1 in murine peritoneal macrophages: comparison of various virus strains with different properties.
Replication of thymidine kinase deficient herpes simplex virus type 1 in neuronal cell culture: infection of the PC 12 cell.
Replication, latent infection, and reactivation in neuronal culture with a herpes simplex virus thymidine kinase-negative mutant.
Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer.
Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following ganciclovir treatment.
Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma.
Reporter gene imaging: effects of ganciclovir treatment on nucleoside uptake, hypoxia and perfusion in a murine gene therapy tumour model that expresses herpes simplex type-1 thymidine kinase.
Rescue of a tk-plasmid from transgenic mice reveals its episomal transmission.
Rescue of transfected genes from mammalian cells by functional selection in Escherichia coli.
Residual expression of reporter genes in constructs mimicking HIV genome organization.
Resistance developing after long-term ganciclovir prodrug treatment in a preclinical model of NSCLC.
Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.
Resistance of herpes simplex virus type 1 to acyclovir: thymidine kinase gene mutagenesis study.
Resistance of peripheral autonomic neurons to in vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activity.
Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades.
Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme.
Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir.
Retinoic acid stimulates transcriptional activity from the alkaline phosphatase promoter in the immortalized rat calvarial cell line, RCT-1.
Retrovector encoding a green fluorescent protein-herpes simplex virus thymidine kinase fusion protein serves as a versatile suicide/reporter for cell and gene therapy applications.
Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions.
Retroviral suicide vector does not inhibit neointimal growth in a porcine coronary model of restenosis.
Retroviral transfer of herpes simplex thymidine kinase gene into glioma cells causes targeting of gancyclovir cytotoxic effect.
Retroviral transfer of herpes simplex virus-thymidine kinase and beta-galactosidase genes into U937 cells with bicistronic vector.
Retroviral transfer of HSV1-TK gene into human lung cancer cell line.
Retroviral vector gene expression in F9 embryonal carcinoma cells.
Retroviral vector-mediated gene transfer into keratocytes in vitro and in vivo.
Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells.
Retrovirally transmitted gene therapy for gastric carcinoma using herpes simplex virus thymidine kinase gene.
Retrovirus long terminal repeats activate expression of coding sequences for the herpes simplex virus thymidine kinase gene.
Retrovirus mediated gene transduction of human T-cell subsets.
Retrovirus transduction: segregation of the viral transforming function and the herpes simplex virus tk gene in infectious Friend spleen focus-forming virus thymidine kinase vectors.
Retrovirus-mediated gene therapy for hepatocellular carcinoma with reversely oriented therapeutic gene expression regulated by alpha-fetoprotein enhancer/promoter.
Retrovirus-mediated gene therapy for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by human alpha-fetoprotein enhancer directly linked to its promoter.
Retrovirus-mediated gene therapy for human hepatocellular carcinoma transplanted in athymic mice.
Retrovirus-mediated gene transfer in primary T lymphocytes: influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire.
Retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for hepatocellular carcinoma.
Retrovirus-mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo.
Retrovirus-mediated herpes simplex virus thymidine kinase gene transfer in pancreatic cancer cell lines: an incomplete antitumor effect.
Retrovirus-mediated in vivo gene therapy using the herpes simplex virus thymidine kinase gene against carcinomatous peritonitis.
Retrovirus-mediated suicide gene transduction in the vitreous cavity of the eye: feasibility in prevention of proliferative vitreoretinopathy.
Retrovirus-mediated suicide gene/prodrug therapy targeting thyroid carcinoma using a thyroid-specific promoter.
Retrovirus-mediated transfer of the herpes simplex type I thymidine kinase gene in alloreactive T lymphocytes.
Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells results in variable efficiency on the bystander killing: implications for gene therapy.
Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and enhanced green fluorescence protein genes in primary T lymphocytes.
Retroviruses and DNA: gene therapy for brain tumours.
Reversibly immortalized hepatic progenitor cell line containing double suicide genes.
Reversion of mutations in the thymidine kinase gene in herpes simplex viruses resistant to phosphonoacetate.
Rhabdomyosarcoma-specific expression of the herpes simplex virus thymidine kinase gene confers sensitivity to ganciclovir.
Ribozyme-mediated selective killing of cancer cells expressing carcinoembryonic antigen RNA by targeted trans-splicing.
RNase P ribozymes for the studies and treatment of human cytomegalovirus infections.
RNase P ribozymes selected in vitro to cleave a viral mRNA effectively inhibit its expression in cell culture.
Role of Equilibrative Nucleobase Transporter 1/SLC43A3 as a Ganciclovir Transporter in the Induction of Cytotoxic Effect of Ganciclovir in a Suicide Gene Therapy with Herpes Simplex Virus Thymidine Kinase.
Role of genotypic analysis of the thymidine kinase gene of herpes simplex virus for determination of neurovirulence and resistance to acyclovir.
Role of herpes simplex virus thymidine kinase expression in viral pathogenesis and latency.
Role of the viral and cellular encoded thymidine kinase in the repair of UV-irradiated herpes simplex virus.
Rostro-caudal maturation of glial cells in the accessory olfactory system during development: involvement in outgrowth of GnRH neurites.
S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase.
Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer.
Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex thymidine kinase DNA followed by ganciclovir therapy in nonhuman primates.
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
Safety Profile of Gutless Adenovirus Vectors Delivered into the Normal Brain Parenchyma: Implications for a Glioma Phase I Clinical Trial.
Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas.
Satellite DNA induces unstable expression of the adjacent herpes simplex virus tk gene cotransfected in mouse cells.
Scintigraphic imaging of HSVtk gene therapy.
Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene.
Sculpting the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve recognition by herpes thymidine kinase.
Second-generation replication-competent oncolytic adenovirus armed with improved suicide genes and ADP gene demonstrates greater efficacy without increased toxicity.
Second-generation triple reporter for bioluminescence, micro-positron emission tomography, and fluorescence imaging.
Secretion of enzymatically active human renin from mammalian cells using an avian retroviral vector.
Secretion of thymidine kinase to increase the effectivity of suicide gene therapy results in the loss of enzymatic activity.
Segregation of mutant ovalbumins and ovalbumin-globin fusion proteins in Xenopus oocytes. Identification of an ovalbumin signal sequence.
Selectable insertion and deletion mutagenesis of the human cytomegalovirus genome using the Escherichia coli guanosine phosphoribosyl transferase (gpt) gene.
Selection for spontaneous null mutations in a chromosomally-integrated HSV-1 thymidine kinase gene yields deletions and a mutation caused by intragenic illegitimate recombination.
Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
Selection of L cell sublines resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Selection of new biologically active molecules from random nucleotide sequences.
Selection of potent non-toxic inhibitory sequences from a randomized HIV-1 specific lentiviral short hairpin RNA library.
Selective ablation of an astroglial subset by toxic gene expression driven by tenascin promoter.
Selective ablation of human embryonic stem cells expressing a "suicide" gene.
Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.
Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.
Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase.
Selective assay for herpes simplex viruses expressing thymidine kinase.
Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene.
Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model.
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents.
Selective expression of foreign genes in glioma cells: use of the mouse myelin basic protein gene promoter to direct toxic gene expression.
Selective expression of transgene using hypoxia-inducible trans-splicing group I intron ribozyme.
Selective gene therapy for human lung adenocarcinoma by tumor-specific expression of herpes simplex virus thymidine kinase gene.
Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector.
Selective inhibition of human T-lymphotropic virus type I-transformed human T-cell growth by a tax-targeted conditionally cytotoxic recombinant retrovirus.
Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene.
Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population.
Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene.
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene.
Selective killing of osteosarcoma cells in culture after retroviral mediated gene transfer of a herpes simplex thymidine kinase suicide gene.
Selective killing of Smad4-negative tumor cells via a designed repressor strategy.
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Selective regression of cells expressing mouse cytoskeleton-associated protein 2 transcript by trans-splicing ribozyme.
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease.
Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression.
Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance.
Sequence analysis of the human glycoprotein hormone alpha-subunit gene 5'-flanking DNA and identification of a potential regulatory element as an alu repetitive sequence.
Sequence requirement for transcription in vitro of the human corticotropin/beta-lipotropin precursor gene.
Sequence requirement for transcription in vivo of the human preproenkephalin A gene.
Sequence requirements for DNA rearrangements induced by the terminal repeat of herpes simplex virus type 1 KOS DNA.
Sequences contained within the promoter of the human thymidine kinase gene can direct cell-cycle regulation of heterologous fusion genes.
Sequences of herpes simplex virus type 1 that inhibit formation of stable TK+ transformants.
Sequences upstream from the mouse c-mos oncogene may function as a transcription termination signal.
Sequential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir.
Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes.
Serial MR in gene therapy for recurrent glioblastoma: initial experience and work in progress.
Serial noninvasive in vivo positron emission tomographic tracking of percutaneously intramyocardially injected autologous porcine mesenchymal stem cells modified for transgene reporter gene expression.
Serological specificity of thymidine kinase activity in herpes simplex virus-transformed L cells.
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: application to HSV-tk/ganciclovir-mediated cytotoxicity.
Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration.
Sexual dimorphism and growth hormone regulation of a hybrid gene in transgenic mice.
Short-term neuropathological aspects of in vivo suicide gene transfer to the F98 rat glioblastoma using liposomal and viral vectors.
Short-term, high-efficiency expression of transfected DNA.
Shuttle vectors conferring hygromycin B resistance to E. coli and to mammalian cells. Differential expression of carboxyterminal fusion proteins.
Significance of amino acid substitutions in the thymidine kinase gene of herpes simplex virus type 1 for resistance.
Significance of resistance of herpes simplex virus to acyclovir.
Silk-elastin-like hydrogel improves the safety of adenovirus-mediated gene-directed enzyme-prodrug therapy.
Simian virus 40 enhancer increases RNA polymerase density within the linked gene.
Similar efficiency of DNA-liposome complexes and retrovirus-producing cells for HSV-tk suicide gene therapy of peritoneal carcinomatosis.
Simplified cosmid vectors for gene transfer to cultured mammalian cells: isolation of the gene for elongation factor 2 from the mouse.
Simultaneous Cre catalyzed recombination of two alleles to restore neomycin sensitivity and facilitate homozygous mutations.
Simultaneous identification of two populations of sympathetic preganglionic neurons using recombinant herpes simplex virus type 1 expressing different reporter genes.
Simultaneous imaging of temporal changes of NF-?B activity and viable tumor cells in Huh7/NF-?B-tk-luc2/rfp tumor-bearing mice.
Single nucleotide polymorphisms of thymidine kinase and DNA polymerase genes in clinical herpes simplex virus type 1 isolates associated with different resistance phenotypes.
Site specificity of DNA methylation and expression of herpes simplex thymidine kinase gene.
Site-directed mutagenesis clarifies the substrate position within the three-dimensional model of the active site of herpes simplex virus type-1 thymidine kinase.
Site-directed mutagenesis in the active site of the herpes simplex virus type 1 thymidine kinase gene.
Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: effects on catalytic activity.
Site-directed mutagenesis of herpes simplex virus type 1 thymidine kinase opposes the importance of amino acid positions 251, 321 and 348 for selective recognition of substrate analogs.
Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line.
Sites of integration of herpes simplex virus type-2 thymidine kinase gene in human chromosomes.
Sitimagene ceradenovec: a gene-based drug for the treatment of operable high-grade glioma.
Slipping and sliding: frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance.
Small Animal PET Imaging of hTERT RNA-Targeted HSV1-tk Gene Expression with Trans-Splicing Ribozyme.
Soluble vascular endothelial growth factor receptor-1 improves therapeutic efficacy of suicide gene therapy in an angiogenesis-independent manner.
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs.
Somatic mutation rates and specificities at TC/AG and GT/CA microsatellite sequences in nontumorigenic human lymphoblastoid cells.
Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase.
Spatial constraints on polyadenylation signal function.
Spatiotemporal PFQNM visualization of the effect of suicide dendriplexes on dividing HeLa cells.
Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses.
Specific ablation of thyroid follicle cells in adult transgenic mice.
Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase.
Specific regression of human cancer cells by ribozyme-mediated targeted replacement of tumor-specific transcript.
Specific viral antigens in rat cells transformed by herpes simplex virus type 2 and in rat tumors induced by inoculation of transformed cells.
SPECT imaging of herpes simplex virus type1 thymidine kinase gene expression by [(123)I]FIAU(1).
Splicing-independent expression of the herpes simplex virus type 1 thymidine kinase gene is mediated by three cis-acting RNA subelements.
Spontaneous and engineered mutant mice as models for experimental and comparative pathology: history, comparison, and developmental technology.
Spontaneous and restriction enzyme-induced chromosomal recombination in mammalian cells.
Spying on cancer: molecular imaging in vivo with genetically encoded reporters.
Stability of retrovirally transduced markers in a rat cell line.
Stability of the transformants obtained by phage particle-mediated gene transfer.
Stable expression in mouse cells of nuclear neoantigen after transfer of a 3.4-megadalton cloned fragment of Epstein-Barr virus DNA.
Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting.
STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy.
STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer.
Stem cells as vectors to deliver HSV/tk gene therapy for malignant gliomas.
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis.
Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays.
Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.
Stereoisomeric selectivity of human deoxyribonucleoside kinases.
Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate.
Stereotactic injection of herpes simplex thymidine kinase vector producer cells (PA317-G1Tk1SvNa.7) and intravenous ganciclovir for the treatment of progressive or recurrent primary supratentorial pediatric malignant brain tumors.
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.
Stimulation of alpha 1 (I) procollagen gene expression in NIH-3T3 cells by the human T cell leukemia virus type 1 (HTLV-1) Tax gene.
Stimulation of human cellular thymidine kinase activity during abortive infection with herpes simplex virus type 2.
Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/GCV bystander effect in vitro.
Stimulation of thymidine kinase activity in baculovirus infected cells is not due to a virus-coded enzyme.
StpC-based gene therapy targeting latent reservoirs of HIV-1.
Strategy for achieving selective killing of carcinomas.
Strength and specificity of different gene promoters in oral cancer cells.
Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Structural characteristics of cationic liposomes with potent enhancing effect on retroviral transduction into human hepatoma cells.
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes.
Structure and expression of human globin genes introduced into mouse fibroblasts.
Structure and inducible regulation of the human c-erb B2/neu promoter.
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids.
Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.
Structures of replacement vectors for efficient gene targeting.
Studies of HIV-2 promoter activity and cell specific ablation.
Studies on cellular tandemization of herpes simplex virus thymidine kinase DNA.
Studies on interactions of dTK-HSV mutants with neurons in vitro.
Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma.
Study of [(18)F]FLT and [(123)I]IaraU for cellular imaging in HSV1 tk-transfected murine fibrosarcoma cells: evaluation of the tracer uptake using 5-fluoro, 5-iodo and 5-iodovinyl arabinosyl uridines as competitive probes.
Studying DNA mutations in human cells with the use of an integrated HSV thymidine kinase target gene.
Studying the biodistribution of positron emission tomography reporter probes in mice.
Substitution of a TATA box from a herpes simplex virus late gene in the viral thymidine kinase promoter alters ICP4 inducibility but not temporal expression.
Substrate diversity of herpes simplex virus thymidine kinase. Impact Of the kinematics of the enzyme.
Substrate specificity of feline and canine herpesvirus thymidine kinase.
Substrate specificity of three viral thymidine kinases (TK): vaccinia virus TK, feline herpesvirus TK, and canine herpesvirus TK.
Suicidal gene therapy for pleural metastasis of lung cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
Suicide gene and cytokines combined nonviral gene therapy for spontaneous canine melanoma.
Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter.
Suicide Gene Therapy Against Malignant Gliomas by the Local Delivery of Genetically Engineered Umbilical Cord Mesenchymal Stem Cells as Cellular Vehicles.
Suicide gene therapy for hepatocellular carcinoma cells by survivin promoter-driven expression of the herpes simplex virus thymidine kinase gene.
Suicide gene therapy for human oral squamous cell carcinoma cell lines with adeno-associated virus vector.
Suicide gene therapy for human uterine adenocarcinoma cells using herpes simplex virus thymidine kinase.
Suicide Gene Therapy for Oral Squamous Cell Carcinoma.
Suicide gene therapy for plasma cell tumors.
Suicide gene therapy for treatment of retinoblastoma in a murine model.
Suicide gene therapy for urogenital cancer: current outcome and prospects.
Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application.
Suicide Gene Therapy Mediated with Exosomes Produced by Mesenchymal Stem/Stromal Cells Stably Transduced with HSV Thymidine Kinase.
Suicide gene therapy of chemically induced mammary tumor in rat: efficacy and distant bystander effect.
Suicide gene therapy of hepatocellular carcinoma and delivery procedure and route of therapeutic gene in vivo.
Suicide gene therapy of ovarian cancer: an experimental study in rats using retroviral-mediated transfer of herpes simplex virus thymidine kinase gene.
Suicide gene therapy of rhabdomyosarcoma.
Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer.
Suicide gene therapy using AAV-HSVtk/ganciclovir in combination with irradiation results in regression of human head and neck cancer xenografts in nude mice.
Suicide gene therapy using adenovirus vector for human oral squamous carcinoma cell line in vitro.
Suicide gene therapy using E. coli beta-galactosidase.
Suicide gene therapy using reducible poly (oligo-D-arginine) for the treatment of spinal cord tumors.
Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy.
Suicide gene therapy with Herpes simplex virus thymidine kinase and ganciclovir is enhanced with connexins to improve gap junctions and bystander effects.
Suicide gene therapy: possible applications in haematopoietic disorders.
Suicide Gene-Mediated Sequencing Ablation Revealed the Potential Therapeutic Mechanism of Induced Pluripotent Stem Cell-Derived Cardiovascular Cell Patch Post-Myocardial Infarction.
Suicide genes as safety switches in T lymphocytes.
Suicide genes: monitoring cells in patients with a safety switch.
Suicide HSVtk gene delivery by neurotensin-polyplex nanoparticles via the bloodstream and GCV Treatment specifically inhibit the growth of human MDA-MB-231 triple negative breast cancer tumors xenografted in athymic mice.
Suicide-gene-Transduced donor T-cells for controlled graft-versus-host disease and graft-versus-tumor.
Suicide-gene-transduced T-cells for the regulation of the graft-versus-leukemia effect.
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter.
Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53.
Suppression of intrachromosomal gene conversion in mammalian cells by small degrees of sequence divergence.
Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation.
Suppression of neointima formation by targeting ?-catenin/TCF pathway.
Suppression of ocular herpes recurrences by a thymidine kinase inhibitor in squirrel monkeys.
Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy.
Surfactant protein A-directed toxin gene kills lung cancer cells in vitro.
Susceptibility of mesothelioma cell lines to adeno-associated virus 2 vector-based suicide gene therapy.
Sustained release of low-dose ganciclovir from a silicone formulation prolonged the survival of rats with gliosarcomas under herpes simplex virus thymidine kinase suicide gene therapy.
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir-mediated cytoxicity by hydroxyurea.
Synergy between the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan.
Synergy of adoptive T-cell therapy and intratumoral suicide gene therapy is mediated by host NK cells.
Syntheses of virus-induced thymidine kinase and viral DNA in herpes simplex type 1 virus-infected chick embryo fibroblasts.
Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.
Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.
Synthesis and antiviral activity of carbocyclic oxetanocin analogues (C-OXT-A, C-OXT-G) and related compounds. II.
Synthesis and antiviral evaluation of ?-l-2'-deoxythreofuranosyl nucleosides.
Synthesis and antiviral evaluation of carbocyclic analogues of 2-amino-6-substituted-purine 3'-deoxyribofuranosides.
Synthesis and application of poly(ethylene glycol)-co-poly(?-amino ester) copolymers for small cell lung cancer gene therapy.
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
Synthesis and biological activity of dansyl thymidines.
Synthesis and biological evaluation of a new acyclic pyrimidine derivative as a probe for imaging herpes simplex virus type 1 thymidine kinase gene expression.
Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy.
Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging.
Synthesis and characterization of a C6 nucleoside analogue for the in vivo imaging of the gene expression of herpes simplex virus type-1 thymidine kinase (HSV1 TK).
Synthesis and evaluation of 2'-deoxy-2'-18F-fluoro-5-fluoro-1-beta-D-arabinofuranosyluracil as a potential PET imaging agent for suicide gene expression.
Synthesis and evaluation of a C-6 alkylated pyrimidine derivative for the in vivo imaging of HSV1-TK gene expression.
Synthesis and evaluation of cis-1-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-5-[(124)I]iodouracil: a new potential PET imaging agent for HSV1-tk expression.
Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expression.
Synthesis and in vitro evaluation of 5-[(18)f]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression.
Synthesis and preclinical evaluation of a new C-6 alkylated pyrimidine derivative as a PET imaging agent for HSV1-tk gene expression.
Synthesis of (99m)Tc(CO)(3)-deoxyuridine derivatives as potential HSV1-tk gene expression imaging agents.
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.
Synthesis of 2-amino-6-(4-[11C]methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester as a novel potential PET gene reporter probe for HBV and HSV-tk in cancers.
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Synthesis of 5-radioiodoarabinosyl uridine analog for probing HSV-1 thymidine kinase gene: an unexpected chelating effect.
Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpesvirus thymidine kinase and cellular enzymes.
Synthesis of a probe for monitoring HSV1-tk reporter gene expression using chemical exchange saturation transfer MRI.
Synthesis of conformationally North-locked pyrimidine nucleosides built on an oxabicyclo[3.1.0]hexane scaffold.
Synthesis of predominantly unspliced cytoplasmic RNAs by chimeric herpes simplex virus type 1 thymidine kinase-human beta-globin genes.
Synthesis of unnatural 7-substituted-1-(2-deoxy-beta-D-ribofuranosyl)isocarbostyrils: "thymine replacement" analogs of deoxythymidine for evaluation as antiviral and anticancer agents.
Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues.
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.
Synthetic radiation-inducible promoters mediated HSV-TK/GCV gene therapy in the treatment of oral squamous cell carcinoma.
Systematic evaluation of chimeric marker genes on dicistronic transcription units for regulated expression of transgenes in vitro and in vivo.
Systemic activation of the immune system during ganciclovir treatment following intratumoral herpes simplex virus type 1 thymidine kinase gene transfer in an adolescent ependymoma patient.
Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis.
Systemic delivery of fusogenic membrane glycoprotein-expressing neural stem cells to selectively kill tumor cells.
Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy.
T cell suicide gene therapy to aid haematopoietic stem cell transplantation.
T cell transduction and suicide with an enhanced mutant thymidine kinase.
T lymphocyte transduction with herpes simplex virus-thymidine kinase (HSV-tk) gene: comparison of four different infection protocols.
T-Cell suicide gene therapy for organ transplantation: induction of long-lasting tolerance to allogeneic heart without generalized immunosuppression.
TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.
Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies.
Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.
Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine.
Targeted cytosine deaminase-uracil phosphoribosyl transferase suicide gene therapy induces small cell lung cancer-specific cytotoxicity and tumor growth delay.
Targeted delivery of DNA encoding cytotoxic proteins through high-affinity fibroblast growth factor receptors.
Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene.
Targeted expression of E. coli purine nucleoside phosphorylase and Fludara for prostate cancer therapy.
Targeted expression of herpes simplex virus thymidine kinase in adenovirus-infected cells reduces virus titers upon treatment with ganciclovir in vitro.
Targeted gene delivery by tropism-modified adenoviral vectors.
Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor.
Targeted gene therapy for cancer: herpes simplex virus thymidine kinase gene-mediated cell killing leads to anti-tumour immunity that can be augmented by co-expression of cytokines in the tumour cells.
Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system.
Targeted gene therapy.
Targeted in vivo delivery of therapeutic gene into experimental squamous cell carcinomas using anti-epidermal growth factor receptor antibody: immunogene approach.
Targeted killing effects of double CD and TK suicide genes controlled by survivin promoter on gastric cancer cell.
Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter.
Targeted killing of migrating glioma cells by injection of HTK-modified glioma cells.
Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer.
Targeted retardation of hepatocarcinoma cells by specific replacement of alpha-fetoprotein RNA.
Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors.
Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model.
Targeted Type 2 Alveolar Cell Depletion. A Dynamic Functional Model for Lung Injury Repair.
Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells.
Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene.
Targeting of an inducible toxic phenotype in animal cells.
Targeting of herpes simplex virus 1 thymidine kinase gene sequences into the OCT4 locus of human induced pluripotent stem cells.
Targeting of suicide gene delivery in pancreatic cancer cells via FGF receptors.
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Targeting Tumor Stroma Using Engineered Mesenchymal Stem Cells Reduces the Growth of Pancreatic Carcinoma.
Tat8-TK/GCV Suicide Gene Therapy Induces Pancreatic Tumor Regression In Vivo.
Tat8-TK/GCV suicide gene therapy induces pancreatic tumor regression in vivo.
TATA-dependent enhancer stimulation of promoter activity in mice is developmentally acquired.
Tentative novel mechanism of the bystander effect in glioma gene therapy with HSV-TK/GCV system.
TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection.
The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.
The 5'-flanking region of the mouse thymidylate synthase gene is necessary but not sufficient for normal regulation in growth-stimulated cells.
The 5'-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription.
The 5'-flanking sequences of the human growth hormone gene contain a cell-specific control element.
The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase.
The adeno-associated virus-mediated HSV-TK/GCV suicide system: a potential strategy for the treatment of bladder carcinoma.
The adenovirus tripartite leader sequence can alter nuclear and cytoplasmic metabolism of a non-adenovirus mRNA within infected cells.
The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring.
The alpha promoter regulator-ovalbumin chimeric gene resident in human cells is regulated like the authentic alpha 4 gene after infection with herpes simplex virus 1 mutants in alpha 4 gene.
The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cells.
The anti-tumor effect of human monocyte-derived dendritic cells loaded with HSV-TK/GCV induced dying cells.
The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for viral replication.
The association of herpes simplex virus with squamous carcinoma of the cervix, and studies of the virus thymidine kinase gene.
The association of thymidine kinase activity and thymidine transport in Escherichia coli.
The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions.
The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine.
The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes.
The clinical course and management of cervical cancer with splenic metastasis: Case report and review of the literature.
The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice.
The construction of cosmid libraries which can be used to transform eukaryotic cells.
The cytostatic activity of 5-(1-azidovinyl)-2'-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (lambda = 254 nm) exposure.
The design, synthesis and properties of highly potent and selective inhibitors of herpes simplex virus types 1 and 2 thymidine kinase.
The drug verapamil inhibits bystander killing but not cell suicide in thymidine kinase-ganciclovir prodrug-activated gene therapy.
The E1b promoter of Ad12 in mouse L tk- cells is activated by adenovirus region E1a.
The effect of cell synchronization on the efficiency of stable gene transfer by electroporation.
The effect of E1 mutations on biochemical transformation by an adenovirus carrying the herpes simplex virus thymidine kinase gene in region E3.
The effect of matrix attached regions (MAR) and specialized chromatin structure (SCS) on the expression of gene constructs in cultured cells and in transgenic mice.
The effect of promoter strength in adenoviral vectors containing herpes simplex virus thymidine kinase on cancer gene therapy in vitro and in vivo.
The effect of substrate binding on the conformation and structural stability of Herpes simplex virus type 1 thymidine kinase.
The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats.
The effects of calcium channel blockers on nuclear factor kappa B activation in the mesangium cells.
The effects of insertions on mammalian intrachromosomal recombination.
The efficacy of retroviral herpes simplex virus thymidine kinase gene transfer and ganciclovir treatment on the inhibition of melanoma growth in vitro and in vivo.
The efficiency of genetic transformation of mammalian cells by transfection and microinjection depends on the transferred gene.
The Epstein-Barr virus (EBV) early promoter DR contains a cis-acting element responsive to the EBV transactivator EB1 and an enhancer with constitutive and inducible activities.
The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.
The equine herpes virus 4 thymidine kinase is a better suicide gene than the human herpes virus 1 thymidine kinase.
The equine herpesvirus type 1 immediate-early gene product contains an acidic transcriptional activation domain.
The evaluation of adenoviral p53-mediated bystander effect in gene therapy of cancer.
The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.
The follicle-stimulating hormone (FSH) beta- and common alpha-subunits are expressed in mouse testis, as determined in wild-type mice and those transgenic for the FSH beta-subunit/herpes simplex virus thymidine kinase fusion gene.
The FSH beta-subunit promoter directs the expression of Herpes simplex virus type 1 thymidine kinase to the testis of transgenic mice.
The gene encoding the late nonstructural 36K protein of vaccinia virus is essential for virus reproduction.
The gene encoding the myeloid-related protein 14 (MRP14), a calcium-binding protein expressed in granulocytes and monocytes, contains a potent enhancer element in the first intron.
The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPbeta.
The herpes simplex virus thymidine kinase gene as a conditional negative-selection marker gene in Arabidopsis thaliana.
The herpes simplex virus thymidine kinase gene is not transcribed in Saccharomyces cerevisiae.
The herpes simplex virus thymidine kinase gene promoter contains a novel thyroid hormone response element.
The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter.
The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.
The human cytomegalovirus regulatory protein UL69 and its effect on mRNA export.
The human histidine decarboxylase promoter is regulated by gastrin and phorbol 12-myristate 13-acetate through a downstream cis-acting element.
The human norepinephrine transporter in combination with 11C-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy.
The immunoglobulin octanucleotide: independent activity and selective interaction with enhancers.
The impact of retroviral suicide gene transduction procedures on T cells.
The in vitro evaluation of nucleoside analogues as probes for use in the noninvasive diagnosis of herpes simplex encephalitis.
The influence of chromosomal location on the expression of two transgenes in mice.
The insulinoma-associated 1: a novel promoter for targeted cancer gene therapy for small-cell lung cancer.
The internal ribosomal entry site of the encephalomyocarditis virus enables reliable coexpression of two transgenes in human primary T lymphocytes.
The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene.
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma.
The location of v-src in a retrovirus vector determines whether the virus is toxic or transforming.
The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells.
The murine alpha B-crystallin/small heat shock protein enhancer: identification of alpha BE-1, alpha BE-2, alpha BE-3, and MRF control elements.
The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication.
The N-terminal region of E2F-1 is required for transcriptional activation of a new class of target promoter.
The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction.
The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants.
The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene.
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.
The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT.
The piggyback transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT.
The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene.
The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP.
The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease.
The rational of catalytic activity of herpes simplex virus thymidine kinase. a combined biochemical and quantum chemical study.
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
The region of mouse mammary tumor virus DNA containing the long terminal repeat includes a long coding sequence and signals for hormonally regulated transcription.
The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line.
The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells.
The replication of viral and cellular DNA in human herpesvirus 6-infected cells.
The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy.
The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy.
The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells.
The role of herpes simplex thymidine kinase expression in neurovirulence and latency in newborn vs. adult mice.
The role of herpes simplex virus thymidine kinase in the treatment of solid tumours.
The role of herpes simplex virus type 1 thymidine kinase in pathogenesis.
The role of herpes simplex virus-1 thymidine kinase alanine 168 in substrate specificity.
The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene.
The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: assessment of antitumor efficacy and toxicity.
The search for homology does not limit the rate of extrachromosomal homologous recombination in mammalian cells.
The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene.
The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator.
The site of integration of the herpes simplex virus type 1 thymidine kinase gene in human cells transformed by an HSV-1 DNA fragment.
The size and ratio of homologous sequence to non-homologous sequence in gene disruption cassette influences the gene targeting efficiency in Beauveria bassiana.
The Sp1 transcription factor regulates cell type-specific transcription of MUC1.
The stereochemical course of phosphoryl transfer catalyzed by herpes simplex virus type I-induced thymidine kinase.
The structure and function of a eukaryotic promoter.
The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.
The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway.
The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters.
The three-dimensional structure of thymidine kinase from herpes simplex virus type 1.
The thymidine kinase gene of herpes simplex virus type 1: cell-free protein synthesis and substrate specificity studies.
The thymidine kinase/ganciclovir-mediated "suicide" effect is variable in different tumor cells.
The transcription of human alpha 1(I) procollagen gene (COL1A1) is suppressed by tumour necrosis factor-alpha through proximal short promoter elements: evidence for suppression mechanisms mediated by two nuclear-factorbinding sites.
The treatment of malignant mesothelioma with a gene modified cancer cell line: a phase I study.
The upstream regulatory region of the human papilloma virus-16 contains an E2 protein-independent enhancer which is specific for cervical carcinoma cells and regulated by glucocorticoid hormones.
The viral thymidine kinase gene as a tool for the study of mutagenesis in Trypanosoma brucei.
The zinc ring finger in the bICP0 protein encoded by bovine herpesvirus-1 mediates toxicity and activates productive infection.
Theranostic Imaging of Cancer Gene Therapy.
Therapeutic efficacy of human hepatocyte transplantation in a SCID/uPA mouse model with inducible liver disease.
Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.
Therapeutic potency of transduction with herpes simplex virus thymidine kinase gene against multidrug resistant mouse leukemia cells.
Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase.
Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses.
Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene.
Thy-1 tk transgenic mice with a conditional lymphocyte deficiency.
Thymidine kinase (TK) activity in herpes simplex virus type 1 recombinants that carry insertions affecting regulation of the TK gene.
Thymidine kinase (TK) gene therapy of solid tumors: valacyclovir facilitates outpatient treatment.
Thymidine kinase activity of biochemically transformed mouse cells after superinfection by thymidine kinase-negative, temperature-sensitive, herpes simplex virus mutants.
Thymidine kinase activity of herpes simplex virus temperature-sensitive mutants.
Thymidine kinase activity of ocular herpes simplex isolates resistant to IUDR therapy.
Thymidine kinase as a selectable marker for studying the biogenesis of glycosomes in Trypanosoma brucei.
Thymidine kinase deficient human cells have increased UV sensitivity in their capacity to support herpes simplex virus but normal UV sensitivity for colony formation.
Thymidine kinase deletion mutants of herpes simplex virus type 1.
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
Thymidine kinase gene delivery using curcumin loaded peptide micelles as a combination therapy for glioblastoma.
Thymidine Kinase Gene Modified Bone Marrow Mesenchymal Stem Cells as Vehicles for Anti-tumor Therapy.
Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses.
Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer.
Thymidine kinase gene transfer by herpes simplex virus.
Thymidine kinase mutants obtained by random sequence selection.
Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses.
Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency.
Thymidine kinase of herpes simplex virus type 1 strain KOS lacks mutator activity.
Thymidine kinase sequence analysis of herpes simplex virus type 1 strains present in different compartments in an atypical impetiginous rash on the lesional skin of a burn patient.
Thymidine Kinase Suicide Gene-mediated Ganciclovir Ablation of Autologous Gene-modified Rhesus Hematopoiesis.
Thymidine kinase, DNA synthesis and cancer.
Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production.
Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice.
Thymidine kinaseless revertants of Ltk- cells transformed by herpes simplex virus type 1 are resistant to retransformation by homologous virus.
Thymidine uptake, thymidine incorporation, and thymidine kinase activity in marine bacterium isolates.
Thymidine utilization by tut mutants and facile cloning of mutant alleles by plasmid conversion in S. cerevisiae.
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon.
Thyroid hormone-responsive elements of the prolactin gene: evidence for both positive and negative regulation.
Thyroid hormones regulate rat thyrotropin beta gene promoter activity expressed in GH3 cells.
Tissue specific promoters in targeting systemically delivered gene therapy.
Tissue-specific determinants of human atrial natriuretic factor gene expression in cardiac tissue.
Tissue-specific DNA binding of nuclear proteins that bind to the adenovirus inverted terminal repeat.
Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice.
Tissue-specific expression of HSV-tk gene can induce efficient antitumor effect and protective immunity to wild-type hepatocellular carcinoma.
Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors.
Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems.
Titration of Variant HSV1-tk Gene Expression to Determine the Sensitivity of 18F-FHBG PET Imaging in a Prostate Tumor.
TK-GFP fusion gene virus vectors as tools for studying the features of HSV-TK/ganciclovir cancer gene therapy in vivo.
Tomato thymidine kinase-based suicide gene therapy for malignant glioma-an alternative for Herpes Simplex virus-1 thymidine kinase.
Total vascular exclusion of the liver enhances the efficacy of retroviral-mediated associated thymidine kinase and interleukin-2 genes transfer against multiple hepatic tumors in rats.
Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells.
Towards ?-globin gene-targeting with integrase-defective lentiviral vectors
Towards ?-globin gene-targeting with integrase-defective lentiviral vectors.
Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.
Towards Fibroid Gene Therapy: Adenovirus-Mediated Delivery of Herpes Simplex Virus 1 Thymidine Kinase Gene/Ganciclovir Shrinks Uterine Leiomyoma in the Eker Rat Model.
Towards global and long-term neurological gene therapy: unexpected transgene dependent, high-level, and widespread distribution of HSV-1 thymidine kinase throughout the CNS.
Toxicity assessment of intratumoral injection of the herpes simplex type I thymidine kinase gene delivered by retrovirus in patients with refractory cancer.
Toxicity studies and distribution dynamics of retroviral vectors following intrathecal administration of retroviral vector-producer cells.
Toxicity studies in thymidine kinase-deficient herpes simplex virus therapy for malignant astrocytoma.
Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors.
trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.
trans activation of gene expression by v-myb.
trans activation of the simian virus 40 late promoter by large T antigen requires binding sites for the cellular transcription factor TEF-1.
Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene.
trans-activation of cellular and viral promoters by a transforming nonkaryophilic simian virus 40 large T antigen.
Trans-activation of viral tk promoters by proteins encoded by varicella zoster virus open reading frames 61 and 62.
Trans-complementing adenoviral vectors for oncolytic therapy of malignant melanoma.
Transactivation of a late herpes simplex virus promoter.
Transcellular transfer of active HSV-1 thymidine kinase mediated by an 11-amino-acid peptide from HIV-1 Tat.
Transcription and translation of the herpes simplex virus type 1 thymidine kinase gene after microinjection into Xenopus laevis oocytes.
Transcription factor AP-2 controls transcription of the human transforming growth factor-alpha gene.
Transcription factor Sp1 recognizes promoter sequences from the monkey genome that are simian virus 40 promoter.
Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter.
Transcription from the polyoma late promoter in cells stably transformed by chimeric plasmids.
Transcription initiation of transfected mouse mammary tumor virus LTR DNA is regulated by glucocorticoid hormones.
Transcription of a trout protamine gene in vitro: the effects of alteration of promoters.
Transcription of DNA injected into Xenopus oocytes is influenced by template topology.
Transcription of herpes simplex virus genes in vivo: overlap of a late promoter with the 3' end of the early thymidine kinase gene.
Transcription of the simian virus 40 genome in DNA-transformed murine teratocarcinoma stem cells.
Transcriptional activation of fibroblast growth factor 1.B promoter is mediated through an 18-base pair cis-acting element.
Transcriptional activation of NF-kappa B activity by Epstein-Barr virus (EBV) LMP1 as a selective therapeutic strategy for EBV-associated diseases.
Transcriptional analysis of the 5'-noncoding region of the human involucrin gene.
Transcriptional induction of the human prolactin gene by cAMP requires two cis-acting elements and at least the pituitary-specific factor Pit-1.
Transcriptional insulation of the human keratin 18 gene in transgenic mice.
Transcriptional regulation of Kaposi's sarcoma-associated herpesvirus-encoded oncogene viral interferon regulatory factor by a novel transcriptional silencer, Tis.
Transcriptional regulation of MHC class I gene expression in rat oligodendrocytes.
Transcriptional repression mediated by the PR domain zinc finger gene RIZ.
Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins.
Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma.
Transcriptional targeting of virus-mediated gene transfer by the human hexokinase II promoter.
Transcriptionally targeted in vivo gene therapy for carcinoembrionic antigen-producing adenocarcinoma.
Transcriptionally targeted retroviral vector for combined suicide and immunomodulating gene therapy of thyroid cancer.
Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease.
Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector.
Transduction of a fiber-mutant adenovirus for the HSVtk gene highly augments the cytopathic effect towards gliomas.
Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
Transduction of the Chinese hamster ovary aprt gene by herpes simplex virus.
Transduction of thymidine phosphorylase cDNA facilitates efficacy of cytosine deaminase/5-FC gene therapy for malignant brain tumor.
Transfection and homologous recombination involving single-stranded DNA substrates in mammalian cells and nuclear extracts.
Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays.
Transfection of genes for human cell surface antigens identified by monoclonal antibodies.
Transfection of mouse cells with thymidine kinase gene of herpes simplex virus.
Transfection of mouse fibroblast cells with a promoterless herpes simplex virus thymidine kinase gene: number of integrated gene copies and structure of single and amplified gene sequences.
Transfection of oocytes and other types of ovarian cells in rabbits after direct injection into uterine arteries of adenoviruses and plasmid/liposomes.
Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy.
Transfection with the isolated herpes simplex virus thymidine kinase genes. I. Minimal size of the active fragments from HSV-1 and HSV-2.
Transfection with the isolated herpes simplex virus thymidine kinase genes. II. Evidence for amplification of viral and adjacent cellular DNA sequences.
Transfer and expression of herpes simplex virus thymidine kinase and human globin genes in mammalian cells studied by spot hybridization assays.
Transfer and expression of the gene encoding a human myeloid membrane antigen (gp150).
Transfer of a mutant viral thymidine kinase gene results in temperature-sensitive mouse cells.
Transfer of genes to Chinese hamster ovary cells by DNA-mediated transformation.
Transfer of herpes simplex virus thymidine kinase synthesized in bacteria by a high-expression plasmid to tissue culture cells by protoplast fusion.
Transfer of human globin genes to erythroleukemic mouse cells.
Transfer of nonselectable genes into mouse teratocarcinoma cells and transcription of the transferred human beta-globin gene.
Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA.
Transfer of the herpes simplex thymidine kinase gene from human cells to mouse cells by means of metaphase chromosomes.
Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus.
Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.
Transformation depending on intermolecular homologous recombination is stimulated by UV damage in transfected DNA.
Transformation of human 143 tk- cells with plasmids containing the gene encoding the adenovirus DNA-binding protein.
Transformation of L cells with virus thymidine kinase genes introduced by red cell-mediated microinjection.
Transforming potential of deletion mutants of the SV40 T antigen coding gene in Syrian hamster cells.
Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression.
Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice.
Transgenic indicator mice for studying activated retinoic acid receptors during development.
Transgenic mouse models for gonadal tumorigenesis.
Transgenic reporter mouse for bioluminescence imaging of herpes simplex virus 1 infection in living mice.
Transient expression analyses of DNA extending 2.4 kb upstream of the human renin gene.
Transient expression of deletion mutants of the herpes simplex virus thymidine kinase-encoding gene in mouse fibroblast cells.
Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency.
Traumatic brain injury-induced hippocampal neurogenesis requires activation of early nestin-expressing progenitors.
Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene.
Treatment of experimental osteosarcoma tumors in rat by herpes simplex thymidine kinase gene transfer and ganciclovir.
Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase gene.
Treatment of human papillomavirus (HPV) type 16-infected cells using herpes simplex virus type 1 thymidine kinase-mediated gene therapy transcriptionally regulated by the HPV E2 protein.
Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes.
Treatment of malignant gliomas with a replicating adenoviral vector expressing herpes simplex virus-thymidine kinase.
Treatment of medullary thyroid carcinoma by combined expression of suicide and interleukin-2 genes.
Treatment of mesothelioma with gene-modified PA1STK cells and ganciclovir: a phase I study.
Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene.
Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial.
Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration.
Treatment of rat experimental brain tumors by herpes simplex virus thymidine kinase gene-transduced allogeneic tumor cells and ganciclovir.
Treatment of rat gliomas with recombinant retrovirus harboring Herpes simplex virus thymidine kinase suicide gene.
Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir.
Treatment of thyroid carcinoma cells with four different suicide gene/prodrug combinations in vitro.
Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus.
Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses.
Tumor cells escape suicide gene therapy by genetic and epigenetic instability.
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
Tumor Restrictive Suicide Gene Therapy for Glioma Controlled by the FOS Promoter.
Tumor Tropism of Intravenously Injected Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells and Their Gene Therapy Application in a Metastatic Breast Cancer Model.
Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy.
Tumor-directed gene therapy in mice using a composite nonviral gene delivery system consisting of the piggyBac transposon and polyethylenimine.
Tumor-selective gene transduction and cell killing with an oncotropic autonomous parvovirus-based vector.
Tumor-specific gene expression using regulatory elements of the glucose transporter isoform 1 gene.
Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter.
Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PET.
Tumor-specific promoter-driven adenoviral therapy for insulinoma.
Tumor-targeted Salmonella as a novel anticancer vector.
Tumor-Targeted Salmonella: Strain Development and Expression of the HSV-tK Effector Gene.
Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells.
Tumoricidal effect of human olfactory ensheathing cell mediated suicide gene therapy in human glioblastoma cells.
Turning immunological memory into amnesia by depletion of dividing T cells.
Two functional estrogen response elements are located upstream of the major chicken vitellogenin gene.
Two thymidine kinase deficient herpes simplex viruses exhibit unexpected virulence properties.
Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter.
Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters.
Two-step transcriptional amplification-lipid-based nanoparticles using PSMA or midkine promoter for suicide gene therapy in prostate cancer.
Type and position of promoter elements in retroviral vectors have substantial effects on the expression level of an enhanced green fluorescent protein reporter gene.
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases.
Ultrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice.
Ultraviolet reactivation of herpes simplex virus is mutagenic and inducible in mammlian cells.
Ultraviolet stimulation of intermolecular homologous recombination in Chinese hamster ovary cells.
Ultraviolet-induced reactivation, amplification, and hypomethylation of a herpes simplex virus thymidine kinase gene.
Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response.
Uncoupling of 2-fluoro-2-deoxyglucose transport and phosphorylation in rat hepatoma during gene therapy with HSV thymidine kinase.
Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.
Unequal homologous recombination between tandemly arranged sequences stably incorporated into cultured rat cells.
Unrepairable DNA double-strand breaks initiate cytotoxicity with HSV-TK/ganciclovir.
Uptake of [125I]iododeoxycytidine by cells infected with herpes simplex virus: a rapid screening test for resistance to acyclovir.
Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer.
Use of a tissue-specific promoter for targeted expression of the herpes simplex virus thymidine kinase gene in cervical carcinoma cells.
Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1.
Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice.
Use of DNA-mediated gene transfer to analyze the role of H-2Ld in controlling the specificity of anti-vesicular stomatitis virus cytotoxic T cells.
Use of EBV-based Vector/HVJ-liposome complex vector for targeted gene therapy of EBV-associated neoplasms.
Use of Epstein-Barr virus nuclear antigen-1 in targeted therapy of EBV-associated neoplasia.
Use of gastrin-releasing peptide promoter for specific expression of thymidine kinase gene in small-cell lung carcinoma cells.
Use of H19 regulatory sequences for targeted gene therapy in cancer.
Use of herpes simplex virus thymidine kinase to improve the antiviral activity of zidovudine.
Use of isotopically chiral [4'-13C]penciclovir and 13C NMR to determine the specificity and absolute configuration of penciclovir phosphate esters formed in HSV-1 and HSV-2 infected cells and by HSV-1-encoded thymidine kinase.
Use of protamine to augment adenovirus-mediated cancer gene therapy.
Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system.
Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro.
Use of the mouse mammary tumor virus long terminal repeat to promote steroid-inducible expression of v-mos.
Use of the polymerase chain reaction to detect herpes simplex virus DNA in paraffin sections of human brain at necropsy.
Use of Thymidine Kinase Recombinant Adenovirus and Ganciclovir Mediated Mouse Liver Preconditioning for Hepatocyte Xenotransplantation.
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
Use of TK-cells in haploidentical hematopoietic stem cell transplantation.
Use of transcriptional regulatory elements of the MUC1 and ERBB2 genes to drive tumour-selective expression of a prodrug activating enzyme.
Use of tumor-targeting trans-splicing ribozyme for cancer treatment.
Use of von Willebrand factor promoter to transduce suicidal gene to human endothelial cells, HUVEC.
Use of [125I]deoxycytidine to detect herpes simplex virus-specific thymidine kinase in tissues of latently infected guinea pigs.
Using HSV-thymidine kinase for safety in an allogeneic salivary graft cell line.
Using [¹?F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model.
Utility of TK/GCV in the context of highly effective oncolysis mediated by a serotype 3 receptor targeted oncolytic adenovirus.
Utilization of internal AUG codons for initiation of protein synthesis directed by mRNAs from normal and mutant genes encoding herpes simplex virus-specified thymidine kinase.
Utilization of variant-type of human alpha-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma.
UV cross-link mapping of the substrate-binding site of an RNase P ribozyme to a target mRNA sequence.
Vaccinia virus encodes a thymidylate kinase gene: sequence and transcriptional mapping.
Valproic acid enhances anti-tumor effect of mesenchymal stem cell mediated HSV-TK gene therapy in intracranial glioma.
Variable expression of the herpes simplex virus thymidine kinase gene in Nicotiana tabacum affects negative selection.
Variable responsiveness of hormone-inducible hybrid genes in different cell lines.
Variations in transcription-repair coupling in mouse cells.
Vascular damage and anti-angiogenic effects of tumor vessel-targeted adenovirus-mediated herpes simplex virus thymidine kinase gene.
Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis.
Verapamil enhances the efficiency of DNA-mediated gene transfer in mammalian cells.
Vesicular stomatitis virus G pseudotyped retrovector mediates effective in vivo suicide gene delivery in experimental brain cancer.
Viral therapies for glioblastoma and high-grade gliomas in adults: a systematic review.
Viral-specific thymidine kinase in sensory ganglia of mice infected with herpes simplex virus.
Virus specified enzyme activity and RNA species in herpes simplex virus type 1 transformed mouse cells.
Virus type-specific thymidine kinase in cells biochemically transformed by herpes simplex virus types 1 and 2.
Virus-free transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment induces tumor cell death.
Virus-specific DNA sequences present in cells which carry the herpes simplex virus thymidine kinase gene.
Visualization of 5T33 myeloma cells in the C57BL/KaLwRij mouse: establishment of a new syngeneic murine model of multiple myeloma.
VP22 enhanced intercellular trafficking of HSV thymidine kinase reduced the level of ganciclovir needed to cause suicide cell death.
VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment.
Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho.
Yeast gene CDC8 encodes thymidylate kinase and is complemented by herpes thymidine kinase gene TK.
Yeast/herpes simplex virus thymidine kinase gene fusions yield fusion proteins with thymidine kinase activity.
[(11)C]FMAU and [(18)F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections.
[125I]deoxycytidine used in a rapid, sensitive, and specific assay for herpes simplex virus type 1 thymidine kinase.
[131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicity.
[A new paradigm of herpes simplex virus type 1 thymidine kinase (HSV-TK)/ganciclovir (GCV)]
[Acyclovir in mycosis fungoides and lymphomatoid papulosis]
[Adenovirus-mediated herpes simplex virus thymidine kinase gene transference and combined drug therapy leads to apoptosis of human epithelial ovarian cancer cells]
[All-trans retinoic acid augments the bystander effect of herpes simplex virus thymidine kinase/ganciclovir system in the treatment of tongue carcinoma cell line]
[Analysis of mutations in DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs]
[Animal experiment on gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration in vivo]
[Anti-proliferative effect of herpes simplex virus thymidine kinase gene system on human Tenon capsule fibroblasts in vitro]
[Antiglioma activity of endothelial progenitor cells transduced with HSV-TK via inhibiting angiogenesis in vitro and in vivo.]
[Autoradiography reporter gene (Ad5-tk carrying HSV1-tk gene) expression imaging in rat myocardium]
[Biochemical evidence for integration of prokaryotic DNA into mammalian cells (author's transl)]
[Chromosomal localization of foreign genes in transgenic mice using dual-color fluorescence in situ hybridization]
[Cloning, expression, isolation and properties of thymidine kinase herpes simplex virus, strain L2].
[Combined interleukin-2 and herpes simplex virus thymidine kinase gene therapy for head and neck squamous cell carcinoma]
[Comparative analysis of herpes simplex virus thymidine kinase gene expression potentiation via HIV-1 Tat-TAR-system and cancer-specific promoters in p53(+) and p53(-) cells]
[Comparative study of the transformation of various thymidine kinase-deficient human and animal cell lines with the thymidine kinase gene of the Herpes simplex virus]
[Construction and expression of hybrid genes based on a deletion mutant of the herpes virus thymidine kinase gene in Escherichia coli]
[Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase genes expressed in vascular endothelial cells.]
[Construction of a plasmid vector of fused protein genes driven by human insulin-like growth factor II P3 promoter]
[Construction of universal vector for gene targeting and analysis of its function]
[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]
[Cys-Flanked Cationic Peptides For Cell Delivery of the Herpes Simplex Virus Thymidine Kinase Gene for Suicide Gene Therapy of Uterine Leiomyoma].
[Cytotoxicity of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells is independent on promoter strength].
[Delivery of "suicide" thymidine kinase gene of herpes virus in the complex with cationic peptide into human hepatoma cells in vitro]
[Different susceptibility of cell lines to thymidine kinase/ganciclovir-mediated killing effect and the way of cell death]
[Double recombinants of the vaccinia virus expressing hepatitis B virus surface antigen and herpes simplex virus thymidine kinase]
[Effect of pAdKDR-tk suicide gene system on tumor vascular endothelial cells in nude mice with nasopharyngeal carcinoma]
[Effect of ultrasound microbubble carrying herpes simplex virus thymidine kinase on hepatocellular carcinoma in mice]
[Effects of herpes simplex virus thymidine kinase gene transduction and prodrug on ovarian cancer cell]
[Experimental studies on the characteristics of suicide gene system HSV-tk/GCV and its effect on dendritic cells]
[Experimental treatment for human colorectal carcinoma by tissue type specific expression of herpes simplex virus thymidine kinase gene]
[Expression in Chinese hamster transformant TK+-cells of the bacterial gene for beta-lactamase]
[Expression of the radio-inducible TK suicide gene controlled by Egr-1 promoter in pancreatic cancer cells: an in vitro experiment]
[Future directions of gene therapy for lung cancer]
[Gene therapy for cancer]
[Gene therapy for cerebral tumors: use of an adenovirus in the glioma C6 rat model]
[Gene therapy of a model of glioblastoma in rats using adenovirus vector encoding the HSVtk gene]
[Gene therapy of cerebral glioblastoma by adenovirus vector. Experimental model in the rat]
[Gene therapy of human pancreatic carcinoma by recombinant retroviral vector expressing herpes simplex virus thymidine kinase gene]
[Gene therapy of primary cancers of the liver: hopes and realities]
[Gene therapy using recombinant adenovirus carrying herpes simplex-thymidine kinase gene to treat mouse B 16 melanoma in vivo]
[Gene therapy. A new prospect in the treatment of liver tumors]
[Generation of a trans-complementable defective recombinant provirus and loading a transgene]
[Genetic transformation of somatic cells. I. Clone of Chinese hamster cells defective in thymidine kinase and characterized by high transformation efficiency]
[Genetic transformation of somatic cells. II. An analysis of the status of the plasmid nucleotide sequences in chromosomal DNA and the thymidine kinase activity in transformant clone cells]
[Genetic transformation of somatic cells. III. An analysis of the status of the plasmid nucleotide sequences in the extrachromosomal DNA of transformant clone cells and the rescue of extrachromosomal molecules of the plasmid DNA]
[Genetic transformation of somatic cells. IV. The rate of loss of transformant phenotype depends on the structure of the transforming DNA and changes when the cells are treated with the tumor promotor 12-o-tetradecanoyl-phorbol-13-acetate]
[Genetic transformation of somatic cells. IX. The loss of the transformant phenotype is accompanied by rearrangements in the plasmid DNA containing the thymidine kinase gene of the herpes virus]
[Genetic transformation of somatic cells. V. Inheritability of the rate of loss of the trait and the stabilization of the transformant phenotype]
[Genetic transformation of somatic cells. VI. Transfer of the trait of the rate of loss of transformant phenotype by means of DNA from cells containing the thymidine kinase gene of the herpes simplex virus]
[Genetic transformation of somatic cells. VII. The loss of the transformant phenotype is accompanied by both stable and unstable changes in DNA]
[Genetic transformation of somatic cells. VIII. The effect of the DNA methylation inhibitor 5-azacytidine on the stability of thymidine kinase-negative and -positive phenotypes of transformant clone cells]
[Hypoxia augments the killing effect of herpes simplex virus thymidine kinase gene expression actuated by the promoter of the vascular endothelial growth factor gene on human hepatocellular tumor cells]
[In vitro and in vivo bystander effect of adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene]
[In vitro experimental study of gene therapy for ovarian cancer with thymidine kinase gene of herpes simplex virus mediated by a non-viral GE7 delivery system]
[In vitro killing effect of mutant thymidine kinase mediated by lentiviral vector on T lymphocytes]
[Inhibition of the reproduction of a herpes simplex I virus carrying mutations in the thymidine kinase and DNA polymerase genes]
[Inhibitory effect of ganciclovir on the HSV1-tk positive subcutaneous tumors transplanted with human ovarian cancer in nude mice]
[Intratumor injection of recombinant attenuated salmonella carrying Mycobacterium tuberculosis heat shock protein 70 and herpes simplex virus thymidine kinase genes to suppress murine melanoma growth].
[Killing effect of adenovirus vector-mediated herpes simplex virus thymidine kinase gene recombinant construct on various cancer cells]
[Long-term and stable expression of transgene mediated by piggyBac transposon in gynecological malignant tumor cells].
[Molecular biological study of the vaccinia virus genome. IV. The late nonstructural 36K protein of vaccinia virus is vitally important]
[Molecular genetics of the Herpes simplex viruses: physical and functional mapping of a new syncytial locus in the region coding thymidine kinase and glycoprotein H]
[Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others]
[Prospect of gene therapy for metastatic foci of gastric cancer]
[Prospects and current data in antiviral chemotherapy]
[Recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene transfer followed by ganiciclovir administration effectively inhibits growth of human small-cell lung cancer in a murine xenotransplant model]
[Selective gene therapy of malignant gliomas using brain-specific promoters: its efficacy and basic investigations]
[Sensitivities to other antiviral drugs and thymidine kinase activity of aciclovir-resistant herpes simplex virus type 1]
[Specific activity of the promoter containing Myc-Max response elements in c-myc-overexpressing cells]
[Structure-activity relation study of anti-herpes associations with a 2'-deoxyuridine basic structure]
[Studies on herpes simplex virus thymidine kinase gene and GCV system for treatment of human bladder carcinoma]
[Studies on thymidine kinase gene (TK) and GCV system for treatment of human retinoblastoma (RB)]
[Study on cotransfection of genes of insulin-like growth factor I and herpes simplex virus thymidine kinase for optimization of wound healing]
[Synergistic effect of all-trans retinoic acid and herpes simplex virus thymidine kinase gene on glioma]
[Targeted killing effect of mucin-1 single chain antibody targeting, lentivirus-mediated suicide gene therapy and ganciclovir in mucin-1+ ovarian epithelial carcinoma cells]
[The adenovirus-mediated HSV-TK/GCV suicide gene system in the treatment of tongue carcinoma cell line]
[The effect of HSV-tk/GCV on hepatic specific damage driven by murine ALB promoter/enhancer]
[The effects of HSV-tk suicide gene and wild-type p53 gene on pleomorphic adenoma cells of salivary gland]
[The killing effects of two prodrug sensitivity genes on human pancreatic carcinoma cells PC-2]
[The mechanism of bystander effect in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy]
[Therapeutic effect of ovarian intra-arterial infusion of GE7-delivery system-mediated HSVl-tk/ganciclovir gene therapy in a rat model of malignant ovarian tumor].
[Transfer of thymidine kinase gene of herpes simplex virus mediated by retrovirus vector into ovarian cancer cells]
[Treatment of experimental liver tumors by in vivo suicide gene transfer in rats]
[Utilization of herpes simplex virus-1 thymidine kinase gene in stem cell transplantation therapy]
[Vesicular stomatitis virus G-protein retrovector mediated a herpes simplex virus thymidine kinase gene transduction and expression in the human retinal pigment epithelial cells]
Herpes Zoster
Analysis of mutations in the thymidine kinase gene of varicella zoster virus associated with resistance to 5-iodo-2'-deoxyuridine and 5-bromo-2'-deoxyuridine.
Antibody responses to early antigens of varicella-zoster virus (VZV) during varicella and zoster.
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8.
Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects.
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Compartmentalization of acyclovir-resistant varicella zoster virus: implications for sampling in molecular diagnostics.
Crystal structure of varicella zoster virus thymidine kinase.
Development of canine herpesvirus based antifertility vaccines for foxes using bacterial artificial chromosomes.
Emergence of acyclovir-resistant varicella zoster virus in an AIDS patient on prolonged acyclovir therapy.
Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants.
Expression of the Varicella Zoster Virus Thymidine Kinase and Cytokines in Patients with Acute Retinal Necrosis Syndrome.
Foreword.
Foscarnet salvage therapy for acyclovir-resistant varicella zoster: report of a novel thymidine kinase mutation and review of the literature.
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Highly purified recombinant varicella Zoster virus thymidine kinase is a homodimer.
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.
Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.
Identification of novel potential inhibitors of varicella-zoster virus thymidine kinase from ethnopharmacologic relevant plants through an in-silico approach.
In-vitro synthesis of functional varicella zoster and herpes simplex viral thymidine kinase.
Metabolic suicide genes in gene therapy.
Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.
Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells.
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.
Rapid sampling of multiple enzyme reactions.
Regulated expression of artificial chimeric genes contained in retroviral vectors: implications for virus-directed enzyme prodrug therapy (VDEPT) and other gene therapy applications.
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.
Testing the sensitivities of noncognate inhibitors to varicella zoster virus thymidine kinase: implications for postherpetic neuralgia therapy with existing agents.
The cytostatic activity of 5-(1-azidovinyl)-2'-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (lambda = 254 nm) exposure.
The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility.
The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy.
Trans-activation of viral tk promoters by proteins encoded by varicella zoster virus open reading frames 61 and 62.
[Contribution of the laboratory in case of resistance to acyclovir of herpes simplex and varicella zoster virus]
[Expression of the varicella zoster virus thymidine kinase and cytokines in patients with acute retinal necrosis syndrome]
Herpesviridae Infections
Atypical Presentation of Herpes Simplex Virus Type 2 Infection Refractory to Treatment With Acyclovir in 2 Hematologic Patients.
Effect on substrate binding of an alteration at the conserved aspartic acid-162 in herpes simplex virus type 1 thymidine kinase.
Epstein--Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrate.
Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies.
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
Thymidine kinase not required for antiviral activity of acyclovir against mouse cytomegalovirus.
HIV Infections
Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects.
Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase.
Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population.
Serum thymidine kinase (TK) evaluation in HIV infection.
Thymidine kinase and deoxycytidine kinase in HIV-infected children.
Hodgkin Disease
Enzymes as prognostic markers and therapeutic indicators in patients with cancer.
Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma.
Serum thymidine kinase as a prognostic marker in Hodgkin's disease.
Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma.
Hydatidiform Mole
[Changes in gene expression profiles of hydatidiform mole and choriocarcinoma as compared with trophoblast hyperplasia]
Hypergammaglobulinemia
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Hyperglycemia
Multimodality Imaging of {beta}-Cells in Mouse Models of Type I and II Diabetes.
Hyperprolactinemia
Does hyperprolactinemia affect hepatic regeneration independent of sex steroids?
Hypersensitivity
Coexpression of a multidrug-resistance gene (MDR1) and herpes simplex virus thymidine kinase gene as part of a bicistronic messenger RNA in a retrovirus vector allows selective killing of MDR1-transduced cells
Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus.
The structure of the thymidine kinase gene promoter: nuclease hypersensitivity correlates with expression.
Hypertension, Portal
Effect of partial portal vein ligation on hepatic regeneration.
Hyperthyroidism
Thymidine kinase activity in homogenates of rat thyroid lobes from euthyroid, hypothyroid and/or hyperthyroid rats incubated with EGF: studies ex vivo in vitro.
Thyroxine effect upon activity of uridine kinase in developing rat cerebellum.
Thyroxine injections do not cause premature induction of thymidine kinase in sg/sg mice.
Hypothyroidism
Effects of hypothyroidism and undernutrition on DNA content and thymidine kinase activity during cerebellar development in the rat.
Infarction, Middle Cerebral Artery
Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.
Infections
3,19-isopropylideneandrographolide suppresses early gene expression of drug-resistant and wild type herpes simplex viruses.
A biochemical investigation of the adenovirus-induced G1 to S phase progression: thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesis.
A new cell-based assay for measuring the forward mutation rate of HIV-1.
A Novel Thyroid Hormone Mediated Regulation of HSV-1 Gene Expression and Replication is Specific to Neuronal Cells and Associated with Disruption of Chromatin Condensation.
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
Activation of gene expression by human herpesvirus 6 is reporter gene-dependent.
Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.
Acyclovir-resistant herpes simplex virus infections in a bone marrow transplant population.
Adenoviral thymidine kinase prodrug gene therapy inhibits sarcoma growth in vivo.
Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer.
Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas.
Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene inhibits vascular smooth muscle cell proliferation and neointima formation following balloon angioplasty of the rat carotid artery.
Advances in the treatment of varicella-zoster virus infections.
Altered properties of thymidine kinase after infection of mouse fibroblast cells with herpes simplex virus.
Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection.
Analysis of deoxycytidine (dC) deaminase activity in herpes simplex virus-infected or HSV TK-transformed cells: association with mycoplasma contamination but not with virus infection.
Antibody-Directed Double Suicide Gene Therapy Targeting of MUC1-Positive Leukemia Cells in Vitro and in Vivo.
Attenuated marmoset herpesvirus isolated from recombinants of virulent marmoset herpesvirus and hybrid plasmids.
Autopsy findings in two cases of neonatal herpes simplex virus infection: detection of virus by immunohistochemistry, in situ hybridization and the polymerase chain reaction.
Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity.
Biochemical characterization of a virus isolate, recovered from a patient with herpes keratitis, that was clinically resistant to acyclovir.
Biochemical transformation of mouse cells by fragments of herpes simplex virus DNA.
Comparative transcriptome analysis reveals resistance-related genes and pathways in Musa acuminata banana 'Guijiao 9' in response to Fusarium wilt.
Comparison of thymidine kinase activities indiced in cells productively infected with herpesvirus saimiri and herpes simplex virus.
Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection.
Consequences of herpes simplex virus type 2 and human cell interaction at supraoptimal temperatures.
Control of expression of the vaccinia virus thymidine kinase gene.
Control of thymidine kinase synthesis in IHD vaccinia virus-infected thymidine kinase-deficient LM cells.
Correlation of the virus sequence content and biological properties of cells carrying the herpes simplex virus type 2 thymidine kinase gene.
Delineation of regulatory domains of early (beta) and late (gamma 2) genes by construction of chimeric genes expressed in herpes simplex virus 1 genomes.
Deoxyribonucleoside triphosphate pools in herpes simplex type 1 infected cells.
Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients.
Detection of immediate early protein ICP27/IE63 and thymidine kinase in the course of reactivation of latent herpes simplex virus 1 infection.
Detection of viral DNA in neonatal herpes encephalitis autopsy tissues by solution-phase PCR: comparison with pathology and immunohistochemistry.
Due to low infection rates no routine anti-infective prophylaxis is required in younger patients with chronic lymphocytic leukaemia during fludarabine-based first line therapy.
Ectopic expression of DNA encoding IFN-alpha 1 in the cornea protects mice from herpes simplex virus type 1-induced encephalitis.
Efficacy of 2'-nor-cyclicGMP in treatment of experimental herpes virus infections.
Efficacy of Cafon gel on cutaneous infection with herpes simplex virus (HSV)-2 and acyclovir-resistant HSV in mice.
Emerging drugs for varicella-zoster virus infections.
Enhanced thymidine kinase activity following infection of green monkey kidney cells by simian adenoviruses, simian papovavirus SV40, and an adenovirus-SV40 "hybrid".
Enhancement of the thymidine kinase activity of human embryonic kidney cells and newborn hamster kidney cells by infection with human adenovirus types 5 and 12.
Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells.
Equine herpesvirus 1 glycoprotein D: mapping of the transcript and a neutralization epitope.
Evaluation of Musculoskeletal and Pulmonary Bacterial Infections With [124I]FIAU PET/CT.
Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.
Experimental infection of pigs with a thymidine kinase negative strain of pseudorabies virus.
Expression of African swine fever virus envelope protein j13L inhibits vaccinia virus morphogenesis.
Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay.
Functional suppression in mammalian cells of nonsense mutations in the herpes simplex virus thymidine kinase gene by suppressor tRNA genes.
Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection.
Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene: long-term follow-up by magnetic resonance imaging.
Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors.
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Hepatoma-specific gene therapy through retrovirus-mediated and targeted gene transfer using an adenovirus carrying the ecotropic receptor gene.
Herpes simplex type 1 infects and establishes latency in the brain and trigeminal ganglia during primary infection of the lip in cotton rats and mice.
Herpes Simplex Virus 1 Reactivates from Autonomic Ciliary Ganglia Independently from Sensory Trigeminal Ganglia To Cause Recurrent Ocular Disease.
Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus.
Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion.
Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation.
Herpes simplex virus thymidine kinase transcripts are absent from both nucleus and cytoplasm during infection in the presence of cycloheximide.
Human cytomegalovirus replicates in gamma-irradiated fibroblasts.
Impact of chronic protein-calorie malnutrition on small intestinal repair after acute viral enteritis: a study in gnotobiotic piglets.
In vivo function of the Murid Herpesvirus-4 ribonucleotide reductase small subunit.
Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells.
Induction capacity and influence of dThdMP on thymidine kinase activity of type 1 and 2 strains of herpes simplex virus.
Influence of dibutyryl cyclic AMP on thymidine uptake by herpes simplex virus infected cells and the intracellular level of cyclic AMP.
Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus types 1 and 2 and pseudorabies virus.
Inhibition by interferon of herpes simplex virus thymidine kinase and DNA polymerase in infected and biochemically transformed cells.
Inhibition of HSV-1 multiplication in rat embryo fibroblasts constitutively expressing the EJ-ras oncogene.
Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo.
Intestinal enzyme profiles in normal and rotavirus-infected mice.
Isolation of a novel fish thymidylate kinase gene, upregulated in Atlantic salmon (Salmo salar L.) following infection with the monogenean parasite Gyrodactylus salaris.
Isolation of mutants of bacteriophage T4 unable to induce thymidine kinase activity. II. Location of the structural gene for thymidine kinase.
Long-term observation of herpes simplex virus type 1 (HSV-1) infection in a child with Wiskott-Aldrich syndrome and a possible reactivation mechanism for thymidine kinase-negative HSV-1 in humans.
Mapping of the thymidine kinase genes of type 1 and type 2 herpes simplex viruses using intertypic recombinants.
Mechanism of resistance to acyclovir in thymidine kinase mutants from Herpes simplex virus type 1: a computational approach.
Molecular Imaging of Cardiovascular Device Infection: Targeting the Bacteria or the Host-Pathogen Immune Response?
Multiplicity reactivation and mutagenesis of trimethylpsoralen-damaged herpes virus in normal and Fanconi's anaemia cells.
Mutant of herpes simplex virus type 1 conditionally able to transform thymidine kinaseless L cells to a tk+ phenotype.
Mutational analysis of the ICP4 binding sites in the 5' transcribed noncoding domains of the herpes simplex virus 1 UL 49.5 gamma 2 gene.
Mycobacterium tuberculosis thymidylate kinase antigen assays for designating incipient, high-risk latent M.tb infection.
Negative regulation of herpes simplex virus type 1 ICP4 promoter by IE180 protein of pseudorabies virus.
Negative regulation of resistance protein-mediated immunity by master transcription factors SARD1 and CBP60g.
Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain.
Neural spread of herpes simplex virus after anterior chamber inoculation.
Novel hepatitis B virus infection mouse model using herpes simplex virus type 1 thymidine kinase transgenic mice.
Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient.
Nucleic acid related compounds. 65. New syntheses of 1-(beta-D-arabinofuranosyl)-5(E)-(2-iodovinyl)uracil (IVAraU) from vinylsilane precursors. Radioiodine uptake as a marker for thymidine kinase positive herpes viral infections.
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Pathogenesis of acyclovir-resistant herpes simplex type 2 isolates in animal models of genital herpes: models for antiviral evaluations.
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Production of herpes simplex virus type 1 thymidine kinase in the presence of thymidine analogues.
Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model.
Protection against Leishmania major challenge infection in mice vaccinated with live recombinant parasites expressing a cytotoxic gene.
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus.
Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion.
Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development.
Recurrent aciclovir-resistant herpes simplex in a child with Wiskott-Aldrich syndrome.
Replication of human cytomegalovirus in human retinal glial cells.
Replication of thymidine kinase deficient herpes simplex virus type 1 in neuronal cell culture: infection of the PC 12 cell.
Replication, latent infection, and reactivation in neuronal culture with a herpes simplex virus thymidine kinase-negative mutant.
Resistance of peripheral autonomic neurons to in vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activity.
Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme.
Retroviral interleukin 4 gene transfer into an interleukin 4-dependent cell line results in autocrine growth but not in tumorigenicity.
Reverse transcriptase and thymidine kinase as markers for tumorigenicity and viral contamination of cells.
Role of the DR2 repeat array in the regulation of the ICP34.5 gene promoter of herpes simplex virus type 1 during productive infection.
Selective induction of chromosomal gene expression by human cytomegalovirus.
Sexual Dimorphism in Hepatocyte Xenograft Models.
Stimulation of human cellular thymidine kinase activity during abortive infection with herpes simplex virus type 2.
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes.
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus.
Syntheses of virus-induced thymidine kinase and viral DNA in herpes simplex type 1 virus-infected chick embryo fibroblasts.
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
T lymphocyte transduction with herpes simplex virus-thymidine kinase (HSV-tk) gene: comparison of four different infection protocols.
TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.
Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.
The expression of P-glycoprotein and cellular kinases is modulated at the transcriptional level by infection and highly active antiretroviral therapy in a primate model of AIDS.
The replication of viral and cellular DNA in human herpesvirus 6-infected cells.
The role of pseudorabies virus thymidine kinase expression in trigeminal ganglion infection.
The zinc ring finger in the bICP0 protein encoded by bovine herpesvirus-1 mediates toxicity and activates productive infection.
Therapeutic efficacy of DNA encoding IFN-alpha1 against corneal HSV-1 infection.
Thymidine kinase (TK) induction after infection of TK-deficient rabbit cell mutants with bovine herpesvirus type 1 (BHV-1): isolation of TK- BHV-1 mutants.
Thymidine kinase gene transfer by herpes simplex virus.
Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter.
Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus.
Transmissible gastroenteritis: sodium transport and the intestinal epithelium during the course of viral enteritis.
Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus.
Ultraviolet reactivation of herpes simplex virus is mutagenic and inducible in mammlian cells.
Virus specified enzyme activity and RNA species in herpes simplex virus type 1 transformed mouse cells.
[(11)C]FMAU and [(18)F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections.
[(125)I]FIAU imaging in a preclinical model of lung infection: quantification of bacterial load.
[Acyclovir-resistant perineal HSV infection revealing chronic lymphoid leukaemia].
[Chemotherapy to thymidine kinase producing virus (HSV-1, HSV-2, VZV) infection]
[Evaluation of the effect of early and massive tritherapy on the expression of cellular factors potentially implicated in antiretroviral therapy resistance]
[Mother-infant and indirect transmission of HSV infection: treatment and prevention]
Infectious Bovine Rhinotracheitis
Attenuation of bovine herpesvirus type 1 by deletion of its glycoprotein G and tk genes and protection against virulent viral challenge.
Identification of the thymidine kinase gene of infectious bovine rhinotracheitis virus and its function in Escherichia coli hosts.
Infectious Mononucleosis
Relationship between nasopharyngeal carcinoma and high antibody titers to Epstein-Barr virus-specific thymidine kinase.
Infertility
A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.
Flagellar and acrosomal abnormalities associated with testicular HSV-tk expression in the mouse.
Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice.
Herpesvirus thymidine kinase transgenes that do not cause male sterility are aberrantly transcribed and translated in the testis.
Presence of human herpes virus 1-thymidine kinase in testis of azoospermic infertile herpes-infected patients.
Recovery of myelin after induction of oligodendrocyte cell death in postnatal brain.
Infertility, Male
Accumulated HSV1-TK Proteins Interfere with Spermatogenesis Through a Disruption of the Integrity of Sertoli-Germ Cell Junctions.
Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients.
Generation of transgenic rats with YACs and BACs: preparation procedures and integrity of microinjected DNA.
Herpesvirus thymidine kinase transgenes that do not cause male sterility are aberrantly transcribed and translated in the testis.
HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells.
Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.
Influenza in Birds
Expression of avian influenza virus hemagglutinin by recombinant fowlpox virus.
Influenza, Human
[Advances in antiviral chemotherapy]
Insulinoma
Human insulin gene expression in transgenic mice: mutational analysis of the regulatory region.
Keratitis
A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits.
A thymidine kinase deficient HSV-2 strain causes acute keratitis and establishes trigeminal ganglionic latency, but poorly reactivates in vivo.
Acyclovir-resistant bilateral keratitis associated with mutations in the HSV-1 thymidine kinase gene.
Acyclovir-resistant varicella-zoster virus keratitis in an immunocompetent patient.
Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient.
HSV-1 thymidine kinase negative vaccine: pathogenicity, protection, and perils.
Keratitis, Herpetic
Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient.
Effect of 9-(4-hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, on clinical recurrences of ocular herpetic keratitis in squirrel monkeys.
Evaluation of tear samples for Herpes Simplex Virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools.
Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: analysis of clinical isolates from herpetic keratitis patients and laboratory strains.
Thymidine kinase activity of ocular herpes simplex isolates resistant to IUDR therapy.
Kidney Diseases
Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease.
Latent Infection
Acute and latent infection by thymidine kinase mutants of herpes simplex virus type 2.
Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes.
Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
Investigation of the mechanism by which herpes simplex virus type 1 LAT sequences modulate preferential establishment of latent infection in mouse trigeminal ganglia.
Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus.
Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside.
Replication, latent infection, and reactivation in neuronal culture with a herpes simplex virus thymidine kinase-negative mutant.
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.
Leiomyoma
Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells.
Towards Fibroid Gene Therapy: Adenovirus-Mediated Delivery of Herpes Simplex Virus 1 Thymidine Kinase Gene/Ganciclovir Shrinks Uterine Leiomyoma in the Eker Rat Model.
Leukemia
A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.
Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction. HGTRI 0103.
Adoptive immunotherapy for leukemia: donor lymphocytes transduced with the herpes simplex thymidine kinase gene.
Antibody-Directed Double Suicide Gene Therapy Targeting of MUC1-Positive Leukemia Cells in Vitro and in Vivo.
Antitumor effects of cytosine deaminase and thymidine kinase fusion suicide gene under the control of mdr1 promoter in mdr1 positive leukemia cells.
Bromodeoxyuridine resistance: thymidine transport and phosphorylation in Friend leukemia cells.
Cerebro-spinal fluid thymidine kinase in acute leukemia.
Changes of serum thymidine kinase in children with acute leukemia.
Construction of a mammalian transducing vector from the genome of Moloney murine leukemia virus.
Cure of mice with established metastatic friend leukemia cell tumors by a combined therapy with tumor cells expressing both interferon-alpha 1 and herpes simplex thymidine kinase followed by ganciclovir.
Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
Deoxycytidine and deoxythymidine kinase activities in plasma of mice and patients with neoplastic disease.
Development and application of quantitative real time PCR and RT-PCR assays that discriminate between the full-length and truncated herpes simplex virus thymidine kinase gene.
Different effect of thymidine kinase loss on TTP pools; comparison among human leukemia cell lines.
DNA-mediated gene transfer in Friend leukemia cells by cotransfection of simian virus 40 DNA with herpes simplex virus thymidine kinase DNA.
Effect of distance between homologous sequences and 3' homology on the frequency of retroviral reverse transcriptase template switching.
Effective suicide gene therapy for leukemia in a model of insertional oncogenesis in mice.
Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation.
Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase--ganciclovir treatment.
Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle.
Gene therapy for adult T cell leukemia using human immunodeficiency virus vector carrying the thymidine kinase gene of herpes simplex virus type 1.
Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia.
In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model.
Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase.
Increased risk of neurological relapse in acute lymphoblastic leukemias with high levels of cerebrospinal fluid thymidine kinase at diagnosis.
Influence of different promoters on the expression of tumor-necrosis-factor-alpha in ls174t human colon-carcinoma cells.
Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene.
Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.
Monitoring therapy in canine malignant lymphoma and leukemia with serum thymidine kinase 1 activity--evaluation of a new, fully automated non-radiometric assay.
Overexpression of human thymidine kinase mRNA without corresponding enzymatic activity in patients with chronic lymphatic leukemia.
Plasma thymidine kinase activity in dogs with lymphoma and leukemia.
Pleiotropic expression of heterologous cytokine/receptor genes in HTLV-1 associated diseases: candidate TRS for chimeric gene therapy.
Retroviral vector gene expression in F9 embryonal carcinoma cells.
Retrovirus transduction: generation of infectious retroviruses expressing dominant and selectable genes is associated with in vivo recombination and deletion events.
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease.
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Serum thymidine kinase in acute nonlymphoblastic leukemia.
Serum thymidine kinase in hairy cell leukemia before and during treatment with alpha interferon.
Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line.
Somatic hybrid of thymus leukemia (.
Structural characteristics of cationic liposomes with potent enhancing effect on retroviral transduction into human hepatoma cells.
Synthesis and antineoplastic activity of some cyano-, carboxy-, carbomethoxy-, and carbamoylborane adducts of heterocyclic amines.
Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy.
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
The role of p16 in the E2F-dependent thymidine kinase regulation.
Therapeutic potency of transduction with herpes simplex virus thymidine kinase gene against multidrug resistant mouse leukemia cells.
Thymidine kinase as a determinant of the response to 5-fluoro-2'-deoxyuridine in transplantable murine leukemias.
Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents.
Thymidine kinase in human leukemia. Expression of the lymphoblastic isoenzyme in three patients with acute myelocytic leukemia.
Thymidine kinase isoenzymes in human acute and chronic lymphatic leukemia.
Thymidine kinase isoenzymes in human acute monocytic leukemia.
Thymidine kinase-independent intracellular delivery of bioactive nucleotides by aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07) in normal human female genital tract epithelial cells and sperm.
Thymidine Kinase: A Biomarker for Recently Diagnosed Acute Leukemia in Pediatric Patients According to the Cell Line Involved.
Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
Transgene amplification and persistence after delivery of retroviral vector and packaging functions with E1/E4-deleted adenoviruses.
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.
[Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues]
[Clinical application of thymidine kinase activity in patients with acute non-lymphocytic leukemia]
[Determination of thymidine kinase in the cerebrospinal fluid as a marker of leukemic meningosis]
[Generation of a trans-complementable defective recombinant provirus and loading a transgene]
Leukemia L1210
Role of thymidine kinase in the inhibitory activity of 5-substituted-2'-deoxyuridines on the growth of human and murine tumor cell lines.
[Biochemical mechanisms of resistance to a new antineoplastic drug CRC 680578 from the nitrosourea class]
Leukemia P388
Therapeutic potency of transduction with herpes simplex virus thymidine kinase gene against multidrug resistant mouse leukemia cells.
[Changes in the activity of thymidine kinase, ribonucleotide reductase and DNA-polymerases during the development of leukemia P388 in mice]
Leukemia, Erythroblastic, Acute
Arabinose furanosyl thymidine: uptake, phosphorylation and incorporation into DNA of mammalian cells.
Azacytidine induces reversion of thymidine kinase deficiency in Friend erythroleukemia cells.
Differential expression of mouse beta/goat beta c, mouse beta/goat beta F, and mouse beta/goat epsilon II hybrid globin genes in murine erythroleukemia cells.
Effect of a dCTP:dTTP pool imbalance on DNA replication fidelity in Friend murine erythroleukemia cells.
Regional gene assignment of human porphobilinogen deaminase and esterase A4 to chromosome 11q23 leads to 11qter.
Leukemia, Hairy Cell
Serum thymidine kinase in hairy cell leukemia before and during treatment with alpha interferon.
Leukemia, Lymphocytic, Chronic, B-Cell
Deoxynucleoside anabolic enzyme levels in acute myelocytic leukemia and chronic lymphocytic leukemia cells.
Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia.
High serum thymidine kinase 1 level predicts poorer survival in patients with chronic lymphocytic leukemia.
Overexpression of human thymidine kinase mRNA without corresponding enzymatic activity in patients with chronic lymphatic leukemia.
Prognostic value of thymidine kinase activity in patients with chronic lymphocytic leukemia.
Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma.
Serum deoxythymidine kinase correlates with peripheral lymphocyte thymidine uptake in chronic lymphocytic leukemia.
Serum thymidine kinase 1 concentration in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors.
Serum thymidine kinase activity: analytical performance, age-related reference ranges and validation in chronic lymphocytic leukemia.
Thymidine kinase isoenzymes in human acute and chronic lymphatic leukemia.
Unavailability of thymidine kinase does not preclude the use of German comprehensive prognostic index: results of an external validation analysis in early chronic lymphocytic leukemia and comparison with MD Anderson Cancer Center model.
[Lipoprotein lipase and serum thymidine kinase level in chronic lymphocytic leukemia and their correlations with other prognostic factors]
Leukemia, Lymphoid
Cytotoxicity of rhenium(I) alkoxo and hydroxo carbonyl complexes in murine and human tumor cells.
Leukemia, Monocytic, Acute
Thymidine kinase isoenzymes in human acute monocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Comparison of cell-labeling methods with ¹²?I-FIAU and ??Cu-PTSM for cell tracking using chronic myelogenous leukemia cells expressing HSV1-tk and firefly luciferase.
Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia.
Thymidine kinase in human leukemia--expression of three isoenzyme variants in six patients with chronic myelocytic leukemia.
[Thymidine kinase activity in leukocytes from patients with chronic myeloid leukemia at various periods in the disease]
Leukemia, Myeloid
Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia.
The nanoparticulate Quillaja saponin KGI exerts anti-proliferative effects by down-regulation of cell cycle molecules in U937 and HL-60 human leukemia cells.
Thymidine kinase from blast cells of myelocytic leukemia.
Thymidine kinase in human leukemia. Expression of the lymphoblastic isoenzyme in three patients with acute myelocytic leukemia.
Leukemia, Myeloid, Acute
Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia.
Deoxynucleoside anabolic enzyme levels in acute myelocytic leukemia and chronic lymphocytic leukemia cells.
Early prediction of therapy response in patients with acute myeloid leukemia by nucleosomal DNA fragments.
Inhibition of adenosine and thymidylate kinases by bisubstrate analogs.
Inhibition of thymidine kinase by P1-(adenosine-5')-P5-(thymidine-5')-pentaphosphate.
Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.
Serum thymidine kinase in acute nonlymphoblastic leukemia.
Thymidine kinase in human leukemia. Expression of the lymphoblastic isoenzyme in three patients with acute myelocytic leukemia.
Leukemia, Promyelocytic, Acute
Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle.
Leukemia, T-Cell
An efficient expression vector for stable expression in human liver cells.
Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein.
Gene therapy for adult T cell leukemia using human immunodeficiency virus vector carrying the thymidine kinase gene of herpes simplex virus type 1.
In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model.
Leukemia-Lymphoma, Adult T-Cell
Cytomegalovirus infection is not necessarily a poor prognostic factor in adult T-cell leukemia/lymphoma.
Lipoma
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
Liver Cirrhosis
Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus.
Liver Diseases
[Serum thymidine kinase activity of various cancer and HBV positive liver diseases]
Liver Failure
Depletion of the other genome-mitochondrial DNA depletion syndromes in humans.
Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat.
Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion.
Liver Neoplasms
Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme.
Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcinoma.
Evolutionary cancer-favoring engineered vaccinia virus for metastatic hepatocellular carcinoma.
Preclinical Safety Evaluation of 18F-FHBG: A PET Reporter Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase (HSV1-tk) or Mutant HSV1-sr39tk's Expression.
Serum AFU, GGT and TK1 levels in PHC patients and their correlation with clinicopathology and diagnostic value.
Suicide gene therapy for urogenital cancer: current outcome and prospects.
Targeted retardation of hepatocarcinoma cells by specific replacement of alpha-fetoprotein RNA.
Liver Neoplasms, Experimental
5-Fluoro-1-(2'-deoxy-2'-fluoro-beta-D-ribofuranosyl) uracil trapping in Morris hepatoma cells expressing the herpes simplex virus thymidine kinase gene.
Comparison of [(14)C]FMAU, [(3)H]FEAU, [(14)C]FIAU, and [(3)H]PCV for Monitoring Reporter Gene Expression of Wild Type and Mutant Herpes Simplex Virus Type 1 Thymidine Kinase in Cell Culture.
Effect of 5-fluorouracil on the release of thymidine kinase from hepatoma cells in vitro.
Glucose transport and apoptosis after gene therapy with HSV thymidine kinase.
Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone.
Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells.
Tumor-associated thymidine kinase in the sera of rats with transplanted hepatomas.
Lumpy Skin Disease
Immune responses to recombinants of the South African vaccine strain of lumpy skin disease virus generated by using thymidine kinase gene insertion.
Importance of thymidine kinase activity for normal growth of lumpy skin disease virus (SA-Neethling).
Protection of Cattle Elicited Using a Bivalent Lumpy Skin Disease Virus-Vectored Recombinant Rift Valley Fever Vaccine.
Lung Diseases
Diagnostic usefulness of 5 tumor-markers in patients with primary lung-cancer.
Lung Neoplasms
Adenoviral herpes simplex virus thymidine kinase gene therapy in an orthotopic lung cancer model.
Clinical and serologic markers of stage and prognosis in small cell lung cancer. A multivariate analysis.
Clinical relevance of thymidine kinase for the diagnosis, therapy monitoring and prognosis of non-operable lung cancer.
Combination gene therapy of lung cancer with conditionally replicating adenovirus and adenovirus-herpes simplex virus thymidine kinase.
Combination therapy with suicide and cytokine genes for hepatic metastases of lung cancer.
Correlation between serum tumor marker levels and tumor proliferation in small cell lung cancer.
Diagnostic usefulness of 5 tumor-markers in patients with primary lung-cancer.
Ectopic expression of herpes simplex virus-thymidine kinase gene in human non-small cell lung cancer cells conferred caspase-activated apoptosis sensitized by ganciclovir.
Effects of the combination of acivicin and cis-diamminedichloroplatinum(II) on thymidylate synthesis of A549 lung cancer cells.
Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.
Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer.
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
Gene therapy with GM-CSF, interleukin-4 and herpes simplex virus thymidine kinase shows strong antitumor effect on lung cancer.
Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors.
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression.
Neuron-specific enolase and thymidine kinase as an aid to the diagnosis and treatment monitoring of small cell lung cancer.
Neuron-specific enolase, thymidine kinase, and tissue polypeptide-specific antigen in diagnosis and response to chemotherapy of small-cell lung cancer.
Non-Small-Cell Lung Cancer: Feasibility of Intratumoral Radiofrequency Hyperthermia-enhanced Herpes Simplex Virus Thymidine Kinase Gene Therapy.
Prognostic value of serum thymidine kinase, tissue polypeptide antigen and neuron specific enolase in patients with small cell lung cancer.
Retroviral transfer of HSV1-TK gene into human lung cancer cell line.
Selective killing of lung cancer cells using carcinoembryonic antigen promoter and double suicide genes, thymidine kinase and cytosine deaminase (pCEA-TK/CD).
Serum detection of thymidine kinase 1 as a means of early detection of lung cancer.
Serum thymidine kinase 1 activity in the prognosis and monitoring of chemotherapy in lung cancer patients: a brief report.
Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer.
Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer.
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Study on the effect of BMSCs-EGFP-tk as mediator of HSV1-tk/GCV suicide gene therapy directed against A549 in vitro.
Suicidal gene therapy for pleural metastasis of lung cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
The Half-Life of Serum Thymidine Kinase 1 Concentration Is an Important Tool for Monitoring Surgical Response in Patients with Lung Cancer: A Meta-Analysis.
Thymidine kinase 1 combined with CEA, CYFRA21-1 and NSE improved its diagnostic value for lung cancer.
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation.
Transcriptionally targeted in vivo gene therapy for carcinoembrionic antigen-producing adenocarcinoma.
XPA-210: a new proliferation marker to characterize tumor biology and progression of renal cell carcinoma.
[A study of thymidine kinase activity in lung cancer tissue]
[Future directions of gene therapy for lung cancer]
[Recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene transfer followed by ganiciclovir administration effectively inhibits growth of human small-cell lung cancer in a murine xenotransplant model]
Lymphadenopathy
Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma.
Lymphatic Metastasis
Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas.
Lymphocytosis
Calf Form Bovine Leukosis with Lameness in a Holstein Heifer.
Serum thymidine kinase activity as a useful marker for bovine leukosis.
[Mantle cell lymphoma as a diagnostic and therapeutic problem]
Lymphoma
3'-azido-3'-deoxythymidine induces deletions in L5178Y mouse lymphoma cells.
A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay.
A mutational assay system using the thymidine kinase locus in mouse lymphoma cells.
A non-radiometric method for measuring serum thymidine kinase activity in malignant lymphoma in dogs.
A sensitive and kinetically defined radiochemical assay for canine and human serum thymidine kinase 1 (TK1) to monitor canine malignant lymphoma.
Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T lymphoma.
Absence of mutagenic effects of sodium dichloroacetate.
Analyses of the genotoxic and mutagenic potential of the products formed after the biotransformation of the azo dye Disperse Red 1.
Analysis of the genotoxicity of anthraquinone dyes in the mouse lymphoma assay.
Analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/- mouse lymphoma cells.
Anti-Transgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Re-directed T Cells in Humans.
Antiviral treatment of Epstein-Barr virus-associated lymphoproliferations.
Ascorbate is detectably mutagenic in the L5178Y TK+/- cell mutation assay.
Bromate induces loss of heterozygosity in the thymidine kinase gene of L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.
Bromodeoxyuridine resistance induced in mouse lymphoma cells by microsomal activation of dimethylnitrosamine.
Characterization of thymidine kinase in L5178Y mouse lymphoma cells.
Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program.
Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies: comparison of trifluorothymidine-resistant and unselected cell colonies from mutagen-treated and control cultures.
Chronic pyelonephritis presenting as multiple tumor-like renal lesions.
Clinical performance of a commercially available thymidine kinase 1 assay for diagnosis of lymphoma in 42 hospitalized horses (2017-2020).
Clinical significance of serum thymidine kinase in adult T-cell leukaemia and acute myeloid leukaemia.
Comparison of chromosome aberration frequency and small-colony TK-deficient mutant frequency in L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity.
Correlation between tumor proliferation and serum levels of beta 2-microglobulin and thymidine kinase in malignant lymphomas.
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.
Cytogenetic analysis of the L5178Y/TK+/- leads to TK-/- mouse lymphoma mutagenesis assay system.
Cytogenetic evidence for hemizygosity at the thymidine kinase locus in P388 mouse lymphoma cells.
Detection of Loss of Heterozygosity in Tk-Deficient Mutants from L5178Y Tk+/--3.7.2C Mouse Lymphoma Cells.
Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis.
Do trifluorothymidine-resistant mutants of L5178Y mouse lymphoma cells re-express thymidine kinase activity following 5-azacytidine treatment?
Dominance of resistance to the alkylating agent 1,2:5,6-dianhydrogalactitol in P388 mouse lymphoma hybrid cells.
Dominant expression of multidrug resistance in intraspecific murine lymphoma hybrid cells.
Effect of pH shifts on the mutant frequency at the thymidine kinase locus in mouse lymphoma L5178Y TK+/- cells.
Enzymes as prognostic markers and therapeutic indicators in patients with cancer.
Evaluation of olestra in short-term genotoxicity assays.
Evaluation of plasma levels of thymidine kinase and mutated p53 in 81 patients with newly diagnosed malignant lymphoma.
Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: methods used and chemicals evaluated.
Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in vitro chromosomal aberration test.
Evidence for chemically-induced structural gene mutations at the thymidine kinase locus in cultured L5178Y mouse lymphoma cells.
Final report on the safety assessment of octoxynol-1, octoxynol-3, octoxynol-5, octoxynol-6, octoxynol-7, octoxynol-8, octoxynol-9, octoxynol-10, octoxynol-11, octoxynol-12, octoxynol-13, octoxynol-16, octoxynol-20, octoxynol-25, octoxynol-30, octoxynol-33, octoxynol-40, octoxynol-70, octoxynol-9 carboxylic acid, octoxynol-20 carboxylic acid, potassium octoxynol-12 phosphate, sodium octoxynol-2 ethane sulfonate, sodium octoxynol-2 sulfate, sodium octoxynol-6 sulfate, and sodium octoxynol-9 sulfate.
Gene-mutation induction by arsenic compounds in the mouse lymphoma assay.
Genetic toxicity studies of glycolipids from Dacryopinax spathularia.
Genotoxicity and subchronic toxicity studies with heated olestra.
Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E.
Genotoxicity assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).
Genotoxicity of gamma-irradiation in L5178Y mouse lymphoma cells.
Hamster hepatocyte-mediated activation of procarcinogens to mutagens in the L5178Y/TK mutation assay.
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia.
Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.
Identification of a heteromorphic microsatellite within the thymidine kinase gene in L5178Y mouse lymphoma cells.
In vitro evaluation of the genotoxicity of poly(anhydride) nanoparticles designed for oral drug delivery.
In vitro mammalian mutagenesis as a model for genetic lesions in human cancer.
In vitro mouse lymphoma (L5178Y Tk?/?-3.7.2C) forward mutation assay.
In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay.
Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms.
Issues for conducting the microtiter version of the mouse lymphoma thymidine kinase (tk) assay and a critical review of data generated in a collaborative trial using the microtiter method.
Large mutagenic lesions are induced by photodynamic therapy in murine L5178Y lymphoblasts.
Loss of P53 heterozygosity is not responsible for the small colony thymidine kinase mutant phenotype in L5178Y mouse lymphoma cells.
Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene.
Mammalian cell HPRT gene mutation assay: test methods.
Mammalian genotoxicity assessment of methylene blue in plasma: implications for virus inactivation.
Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells.
Modeling the mouse lymphoma forward mutational assay: the Gene-Tox program database.
Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.
Monitoring therapy in canine malignant lymphoma and leukemia with serum thymidine kinase 1 activity--evaluation of a new, fully automated non-radiometric assay.
Mouse lymphoma L5178Y thymidine kinase locus assay of 50 compounds.
Mouse lymphoma thymidine kinase gene mutation assay: follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000.
Mouse lymphoma thymidine kinase gene mutation assay: Follow-up meeting of the international workshop on Genotoxicity testing-Aberdeen, Scotland, 2003-Assay acceptance criteria, positive controls, and data evaluation.
Mouse lymphoma thymidine kinase gene mutation assay: International Workshop on Genotoxicity Tests Workgroup report--Plymouth, UK 2002.
Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment.
Mouse lymphoma thymidine kinase locus gene mutation assay: International Workshop on Genotoxicity Test Procedures Workgroup Report.
Mutagenic activity of fluorides in mouse lymphoma cells.
Mutagenic analysis of six disinfection by-products in the Tk gene of mouse lymphoma cells.
Mutagenic screening of marker grenade dyes by the Salmonella reversion assay, L5178Y/TK+/- mouse lymphoma assay, and in vivo sister chromatid exchange analysis in mice.
Mutagenicity and clastogenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in L5178Y/TK+/(-)-3.7.2C mouse lymphoma cells.
Mutagenicity and clastogenicity of proflavin in L5178Y/TK +/- -3.7.2.C cells.
Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: possible role of topoisomerase.
Mutagenicity of metal salts in the L5178Y mouse lymphoma assay.
Mutagenicity of the mycotoxin alternariol in cultured mammalian cells.
Mutagenicity studies of R-amino salt, a metabolite of amaranth (FD & C Red NO. 2), in mouse lymphoma cells heterozygous at the thymidine kinase locus and in the rat dominant lethal test.
Mutagenicity tests of diflubenzuron in the micronucleus test in mice, the L5178Y mouse lymphoma forward mutation assay, and the Ames Salmonella reverse mutation test.
Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.
Non-coplanar 2,2',3,3',4,4',5,5',6,6'-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities.
Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress.
Photofrin II photosensitization is mutagenic at the tk locus in mouse L5178Y cells.
Plasma thymidine kinase activity in dogs with lymphoma and leukemia.
Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. I. Application to genetic toxicological testing.
Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. II. Test validation and interpretation.
Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses.
Primary non-Hodgkin's lymphoma of the gallbladder diagnosed by laparoscopic cholecystectomy.
Procarbazine is a potent mutagen at the heterozygous thymidine kinase (tk +/-) locus of mouse lymphoma assay.
Reactivity of catecholamines and related substances in the mouse lymphoma L5178Y cell assay for mutagens.
Reversion in thymidine kinase deficient variants of mouse lymphoma P388.
Risk classification for large cell lymphoma using lactate dehydrogenase, beta-2 microglobulin, and thymidine kinase.
Safety and toxicological evaluation of a novel, water-soluble undenatured type II collagen.
Safety assessment of a novel ingredient for removable chewing gum.
Safety study of culinary-medicinal Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al. KA21 (higher Basidiomycetes) assessed by prokaryotic as well as eukaryotic systems.
Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas.
Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma.
Serum thymidine kinase activity in clinically healthy and diseased horses: A potential marker for lymphoma.
Serum thymidine kinase activity in dogs with malignant lymphoma: a potent marker for prognosis and monitoring the disease.
Serum thymidine kinase activity: an alternative to histologic markers of cellular proliferation in canine lymphoma.
Serum thymidine kinase and soluble interleukin-2 receptor predict recurrence of malignant lymphoma.
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Serum thymidine kinase in non-Hodgkin lymphomas with special regard to multiple myeloma.
Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected lymphoma cells to nucleoside analogue antiviral agents.
Specific gene mutations in L5178Y cells in culture.
Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction.
Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data.
Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk+/- mouse lymphoma cells.
The Current State of Clinical Application of Serum Biomarkers for Canine Lymphoma.
The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
The L5178Y/tk+/- mouse lymphoma specific gene and chromosomal mutation assay a phase III report of the U.S. Environmental Protection Agency Gene-Tox Program.
The mouse lymphoma assay detects recombination, deletion, and aneuploidy.
The mouse lymphoma assay.
The mouse lymphoma thymidine kinase assay for the assessment and comparison of the mutagenic activity of cigarette mainstream smoke particulate phase.
The mutagenic assay of some hair dye components, using the thymidine kinase locus of L5178Y mouse lymphoma cells.
The mutagenic potency of 4 agents at the thymidine kinase locus in mouse lymphoma L5178Y cells in vitro: effects of exposure time.
The mutagenicity of 5-azacytidine and other inhibitors of replicative DNA synthesis in the L5178Y mouse lymphoma cell.
The spectral karyotype of L5178Y TK?/? mouse lymphoma cells clone 3.7.2C and factors affecting mutant frequency at the thymidine kinase (tk) locus in the microtitre mouse lymphoma assay.
The uptake of 3'-deoxy-3'-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels.
The use of L5178Y mouse lymphoma cells to assess the mutagenic, clastogenic and aneugenic properties of chemicals.
Thymidine kinase (TK) activity as a prognostic parameter of survival in lymphoma patients.
Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma.
Thymidine kinase assay in canine lymphoma.
Thymidine kinase heterozygous L5178Y mouse lymphoma forward mutational assay.
Thymidine kinase isoenzymes in human malignant lymphoma.
Thymidine kinase levels correlate with prognosis in aggressive lymphoma and can discriminate patients with a clinical suspicion of indolent to aggressive transformation.
Tissue enzyme changes in parabiotic rats with subcutaneous lymphoma or fibrosarcoma.
Tumor cells escape suicide gene therapy by genetic and epigenetic instability.
Use of microsatellite DNA polymorphisms on mouse chromosome 11 for in vitro analysis of thymidine kinase gene mutations.
Use of murine L5178Y lymphoma thymidine kinase mutants for in vitro and in vivo antitumour efficacy evaluation of novel thymidylate synthase inhibitors.
Whole genome sequencing analysis of small and large colony mutants from the mouse lymphoma assay.
[A case report of lymphomatoid granulomatosis (LYG) with spontaneous attenuation]
[Evaluation of the Acute Toxicity and Genotoxicity of the Rice Biofortified with ?-Glucan].
[Serum thymidine kinase in the monitoring of lymphoma patients]
Lymphoma, B-Cell
Prognostic Value of High Thymidine Kinase Activity in Previously Untreated Diffuse Large B-Cell Lymphoma Patients Treated by R-CHOP.
There is life in the old dog yet: thymidine kinase as predictive marker in diffuse large B-cell lymphoma.
Lymphoma, Follicular
Anti-Transgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Re-directed T Cells in Humans.
High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma.
Lymphoma, Large B-Cell, Diffuse
Anti-Transgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Re-directed T Cells in Humans.
Deoxynucleoside overproduction in deoxyadenosine-resistant, adenosine deaminase-deficient human histiocytic lymphoma cells.
Prognostic Value of High Thymidine Kinase Activity in Previously Untreated Diffuse Large B-Cell Lymphoma Patients Treated by R-CHOP.
There is life in the old dog yet: thymidine kinase as predictive marker in diffuse large B-cell lymphoma.
Lymphoma, Non-Hodgkin
Activity of serum thymidine kinase in non-Hodgkin lymphoma: relationship to other prognostic factors.
Calf Form Bovine Leukosis with Lameness in a Holstein Heifer.
Circadian variations of interleukin-2 receptors, serum thymidine kinase and beta-2-microglobulin in patients with non-Hodgkin's lymphoma and normal controls.
Clinical significance of circulating CD44 in non-Hodgkin's lymphoma.
Evaluation of serum thymidine kinase 1 activity as a biomarker for treatment effectiveness and prediction of relapse in dogs with non-Hodgkin lymphoma.
Prognostic relevance of thymidine kinase isozymes in adult non-Hodgkin's lymphoma.
Pyrimidine and purine activities in non-Hodgkin's lymphoma. Correlation with histological status and survival.
Retrospective study of the prognostic role of serum thymidine kinase level in CLL patients with active disease treated with fludarabine.
Serum soluble CD27, but not thymidine kinase, is an independent prognostic factor for outcome in indolent non-Hodgkin's lymphoma.
Serum thymidine kinase 1 concentration as a prognostic factor of chemotherapy-treated non-Hodgkin's lymphoma patients.
Thymidine kinase 1 is a potential marker for prognosis and monitoring the response to treatment of patients with breast, lung, and esophageal cancer and non-Hodgkin's lymphoma.
Thymidine kinase and thymidine phosphorylase activities in various types of leukaemia and lymphoma.
Thymidine kinase: a tumor marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications.
Lymphoproliferative Disorders
[Acyclovir in mycosis fungoides and lymphomatoid papulosis]
Malaria
High-performance liquid chromatographic assay for thymidylate synthase from the human malaria parasite, Plasmodium falciparum.
Mild Plasmodium falciparum Malaria following an Episode of Severe Malaria Is Associated with Induction of the Interferon Pathway in Malawian Children.
Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum.
Malaria, Cerebral
Mild Plasmodium falciparum Malaria following an Episode of Severe Malaria Is Associated with Induction of the Interferon Pathway in Malawian Children.
Malnutrition
DNA polymerase and thymidine kinase activities in different regions of rat brain during postnatal development: effect of undernutrition.
Effects of hypothyroidism and undernutrition on DNA content and thymidine kinase activity during cerebellar development in the rat.
Marek Disease
Construction and properties of a turkey herpesvirus recombinant expressing the Marek's disease virus homologue of glycoprotein B of herpes simplex virus.
Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the thymidine kinase and UL24 genes of herpes simplex virus type 1.
Influence of chicken genotype on protection against Marek's disease by a herpesvirus of turkeys recombinant expressing the glycoprotein B (gB) of Marek's disease virus.
Nucleotide and predicted amino acid sequences of the Marek's disease virus and turkey herpesvirus thymidine kinase genes; comparison with thymidine kinase genes of other herpesviruses.
Mastocytoma
Effects of temperature changes on thymidine kinase in heat- and cold-sensitive cell-cycle mutants and 'wild-type' murine P-815 cells.
Selection of highly transfectable variant from mouse mastocytoma P815.
Measles
Construction of vaccinia virus recombinants expressing several measles virus proteins and analysis of their efficacy in vaccination of mice.
Medulloblastoma
Bystander effect in suicide gene therapy using immortalized neural stem cells transduced with herpes simplex virus thymidine kinase gene on medulloblastoma regression.
In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma.
Melanoma
A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.
A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (AdV.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma.
A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. Study Group on Gene Therapy of Metastatic Melanoma.
Antitumor effects on human melanoma xenografts of an amplicon vector transducing the herpes thymidine kinase gene followed by ganciclovir.
Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors.
Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes.
Curcumin plays a synergistic role in combination with HSV-TK/GCV in inhibiting growth of murine B16 melanoma cells and melanoma xenografts.
Diagnostic accuracy and predictive value of the tumor-associated antigen S100 in malignant melanomas: validation by whole body FDG-PET and conventional diagnostics.
Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.
Differential metabolism of thymidine in human lymphoid and melanoma cells in vitro.
Dual addressing of thymidine synthesis pathways for effective targeting of proliferating melanoma.
Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-? and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line.
Efficient gene transfer into Xiphophorus muscle and melanoma by injection of supercoiled plasmid DNA.
Evaluation of combined gene regulatory elements for transcriptional targeting of suicide gene expression to malignant melanoma.
Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
Ex vivo delivery of suicide genes into melanoma cells using epidermal growth factor receptor-specific Fab immunogene.
Gene therapy for metastatic malignant melanoma: evaluation of tolerance to intratumoral injection of cells producing recombinant retroviruses carrying the herpes simplex virus type 1 thymidine kinase gene, to be followed by ganciclovir administration.
Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines.
Increased serum level of thymidine kinase 1 correlates with metastatic site in patients with malignant melanoma.
Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo.
Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus.
Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging.
Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901.
Protocol #0207-544: a phase study to evaluate the safety and pharmacokinetics of Pro-1, a liposome-encapsulated thymidine kinase gene formulation, in patients with stage IV metastatic melanoma.
S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase.
Selective targeting and inducible destruction of human cancer cells by retroviruses with envelope proteins bearing short peptide ligands.
Suppression of Cancer Growth by Nonviral Gene Therapy Based on a Novel Reactive Oxygen Species-responsive Promoter.
The efficacy of retroviral herpes simplex virus thymidine kinase gene transfer and ganciclovir treatment on the inhibition of melanoma growth in vitro and in vivo.
Thymidine kinase in malignant melanoma.
Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma.
Transformation of Bowes melanoma cells with SV40 T antigen.
Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses.
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
[Cytotoxicity of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells is independent on promoter strength].
[Gene therapy using recombinant adenovirus carrying herpes simplex-thymidine kinase gene to treat mouse B 16 melanoma in vivo]
[Intratumor injection of recombinant attenuated salmonella carrying Mycobacterium tuberculosis heat shock protein 70 and herpes simplex virus thymidine kinase genes to suppress murine melanoma growth].
Melanoma, Experimental
Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
Thymidine kinase in malignant melanoma.
Meningeal Carcinomatosis
Intracavitary chemotherapy with 5-fluoro-2'-deoxyuridine (FdUrd) in malignant brain tumors.
Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study.
Toxicity studies and distribution dynamics of retroviral vectors following intrathecal administration of retroviral vector-producer cells.
Meningioma
Progesterone and glucocorticoid receptor activation in meningiomas.
Meningoencephalitis
Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS.
MERRF Syndrome
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
Generation of two isogenic human induced pluripotent stem cell lines from a 15?year-old female patient with MERRF syndrome and A8344G mutation of mitochondrial DNA.
MERRF Classification: Implications for Diagnosis and Clinical Trials.
Photosensitive Epilepsy and Polycystic Ovary Syndrome as Manifestations of MERRF.
Recovery of MERRF Fibroblasts and Cybrids Pathophysiology by Coenzyme Q(10).
[Development of a DNA biochip for detection of known mtDNA mutations associated with MELAS and MERRF syndromes.]
Mesothelioma
A pilot study of systemic corticosteroid administration in conjunction with intrapleural adenoviral vector administration in patients with malignant pleural mesothelioma.
Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma.
Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics.
Enzyme pathology of human mesotheliomas.
Gene therapy for malignant mesothelioma: beyond the infant years.
Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer.
Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene.
Treatment of mesothelioma with gene-modified PA1STK cells and ganciclovir: a phase I study.
Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the herpes simplex virus thymidine kinase gene.
Mesothelioma, Malignant
Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene.
Long-term follow-up of patients with malignant pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy.
Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene.
Metrorrhagia
Direct assay of thymidine kinase bound to ion-exchange paper for dot spotting and enzyme blotting analysis.
Mitochondrial Diseases
An A8296G mutation in the MT-TK gene of a patient with epilepsy - a disease-causing mutation or rare polymorphism?
Mitochondrial Encephalomyopathies
Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies.
Mitochondrial Myopathies
A defect in the thymidine kinase 2 gene causing isolated mitochondrial myopathy without mtDNA depletion.
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy.
Novel mutations in the thymidine kinase 2 gene (TK2) associated with fatal mitochondrial myopathy and mitochondrial DNA depletion.
Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency.
Monkeypox
Nucleotide sequence of the thymidine kinase gene region of monkeypox and variola viruses.
Orthopoxvirus DNA in eurasian lynx, sweden.
Quaternary structure of vaccinia virus thymidine kinase.
Monoclonal Gammopathy of Undetermined Significance
Analysis of thymidine kinase serum levels by novel method DiviTum™ in multiple myeloma and monoclonal gammopathy of undetermined significance - comparison with imaging methods 99mTc-MIBI scintigraphy and 18F-FDG PET/CT.
Serum thymidine kinase and beta-2 microglobulin in monoclonal gammopathies.
Serum thymidine kinase in monoclonal gammopathies. A prospective study. The Cooperative Group for Study and Treatment of Multiple Myeloma.
[Analysis of serum levels of selected biological parameters in monoclonal gammopathy of undetermined significance and multiple myeloma]
Mouth Neoplasms
Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer.
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: application to HSV-tk/ganciclovir-mediated cytotoxicity.
Multiple Myeloma
Adenovirus vector-based purging of multiple myeloma cells.
Analysis of thymidine kinase serum levels by novel method DiviTum™ in multiple myeloma and monoclonal gammopathy of undetermined significance - comparison with imaging methods 99mTc-MIBI scintigraphy and 18F-FDG PET/CT.
Chronobiological circadian aspects of serum lactate dehydrogenase and serum thymidine kinase in monitoring multiple myeloma.
Plasma cell labeling index and beta 2-microglobulin predict survival independent of thymidine kinase and C-reactive protein in multiple myeloma.
Prognostic factors in multiple myeloma.
Prognostic factors in multiple myeloma: role of beta 2-microglobulin and thymidine kinase.
Prognostic value of serum thymidine kinase and beta 2 microglobulin in subjects affected by multiple myeloma.
Retrospective study of the prognostic role of serum thymidine kinase level in CLL patients with active disease treated with fludarabine.
Serum thymidine kinase and beta-2 microglobulin in monoclonal gammopathies.
Serum thymidine kinase as a marker of disease activity in patients with multiple myeloma.
Serum thymidine kinase as a prognostic indicator for patients with multiple myeloma: results from the MRC (UK) V trial.
Serum thymidine kinase in monoclonal gammopathies. A prospective study. The Cooperative Group for Study and Treatment of Multiple Myeloma.
Serum thymidine kinase in non-Hodgkin lymphomas with special regard to multiple myeloma.
[Analysis of serum levels of selected biological parameters in monoclonal gammopathy of undetermined significance and multiple myeloma]
[Biochemical markers of multiple myeloma]
[Serum thymidine kinase in multiple myeloma: I. Relation to selected laboratory indicators in the disease]
[Serum thymidine kinase in multiple myeloma: II. Relation to disease activity and stage]
Muscular Atrophy, Spinal
New Mutations in TK2 Gene Associated With Mitochondrial DNA Depletion.
Muscular Diseases
Advances in primary mitochondrial myopathies.
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy.
Deoxynucleoside Therapy for Thymidine Kinase 2-Deficient Myopathy.
Depletion of the other genome-mitochondrial DNA depletion syndromes in humans.
Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy.
Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency.
Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA.
mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency.
Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy.
New Mutations in TK2 Gene Associated With Mitochondrial DNA Depletion.
Onset and organ-specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation.
Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion.
Myelodysplastic Syndromes
Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes: relationship to development of acute myeloid leukaemia.
[The prognostic significance of serum thymidine kinase in the myelodysplastic syndrome]
Myocardial Infarction
Mechanism of Improved Cardiac Function After Bone Marrow Mononuclear Cell Therapy. Role of Cardiovascular Lineage Commitment.
Multimodality molecular imaging to monitor transplanted stem cells for the treatment of ischemic heart disease.
Myotonia
Genetic neuromuscular disorders: living the era of a therapeutic revolution. Part 2: diseases of motor neuron and skeletal muscle.
Myxoma
The myxoma virus thymidine kinase gene: sequence and transcriptional mapping.
Nasopharyngeal Carcinoma
A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase C modulator: implications for radiosensitization and EBV-targeted therapy.
A novel fusion suicide gene yeast CDglyTK plays a role in radio-gene therapy of nasopharyngeal carcinoma.
Antibodies to Epstein-Barr virus thymidine kinase: a characteristic marker for the serological detection of nasopharyngeal carcinoma.
Diagnosis of nasopharyngeal carcinoma by means of recombinant Epstein-Barr virus proteins.
Immune responses to Epstein-Barr virus lytic proteins in patients with nasopharyngeal carcinoma.
Immunological response of nasopharyngeal carcinoma patients to the Epstein-Barr-virus-coded thymidine kinase expressed in Escherichia coli.
Induction of chemosensitivity in nasopharyngeal carcinoma cells using a human papillomavirus regulatory sequence and the thymidine kinase gene.
Relationship between nasopharyngeal carcinoma and high antibody titers to Epstein-Barr virus-specific thymidine kinase.
Use of antigen expressed in bacteria for detection of EBV-specific thymidine kinase antibodies in sera from patients with nasopharyngeal carcinoma.
[Enhanced thymidine kinase gene vector and its killing effect on nasopharyngeal carcinoma in vitro and in vivo].
Nasopharyngeal Neoplasms
Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase.
Long-circulating liposome-encapsulated ganciclovir enhances the efficacy of HSV-TK suicide gene therapy.
Targeted gene therapy of nasopharyngeal cancer in vitro and in vivo by enhanced thymidine kinase expression driven by human TERT promoter and CMV enhancer.
Neoplasm Metastasis
5-azacytidine induction of thymidine kinase in a spontaneously enzyme-deficient murine tumor line.
Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors.
Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer.
An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice.
Bone metastasis imaging with SPECT/CT/MRI: A preclinical toolbox for therapy studies.
Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model.
Evaluation of tumour markers as differential diagnostic tool in patients with suspicion of liver metastases from breast cancer.
Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir.
Human colorectal malignancy and oral UFT.
Human Embryonic Stem Cell-Derived Endothelial Cells as Cellular Delivery Vehicles for Treatment of Metastatic Breast Cancer.
In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery.
Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.
Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging.
Neural Stem Cells Improve the Delivery of Oncolytic Chimeric Orthopoxvirus in a Metastatic Ovarian Cancer Model.
Papers to appear in forthcoming issues
Preoperative tumor markers as prognostic factors of colorectal liver metastases.
Prognostic Factors After Surgical Treatment of Liver Metastases from Breast Cancer - 19 Years of Experience.
Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas.
Regional versus systemic delivery of recombinant vaccinia virus as suicide gene therapy for murine liver metastases.
Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir.
Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma and Radiofrequency Ablation of Metastases to Lung and Liver.
Serum thymidine kinase in colorectal neoplasia.
Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration.
Suicidal gene therapy for pleural metastasis of lung cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis.
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
The clinical course and management of cervical cancer with splenic metastasis: Case report and review of the literature.
The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis.
Total vascular exclusion of the liver enhances the efficacy of retroviral-mediated associated thymidine kinase and interleukin-2 genes transfer against multiple hepatic tumors in rats.
Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy.
VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization.
[Prognostic value of thymidine kinase in cancer of the breast]
[Study of DNA microarray chip of associated genes of hydatidiform mole]
Neoplasm Micrometastasis
Combination of pet imaging with viral vectors for identification of cancer metastases.
Neoplasm, Residual
[Research Progress on Prognostic Factors of Multiple Myeloma--Review].
Neoplasms
"Click-to-chelate": design and incorporation of triazole-containing metal-chelating systems into biomolecules of diagnostic and therapeutic interest.
"Suicide" gene therapy of breast cancer cells is only cytostatic in vitro but anti-tumoral in vivo on breast MCF7-ras tumor.
(111)In-DOTA-Annexin V for imaging of apoptosis during HSV1-tk/GCV prodrug activation gene therapy in mice with NG4TL4 sarcoma.
(18)F-FLT PET imaging of cellular proliferation in pancreatic cancer.
(3)H-Penciclovir ((3)H-PCV) Uptake Assay.
(99m)Tc-EC-guanine: synthesis, biodistribution, and tumor imaging in animals.
(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12-dimethylbenz[a]anthracene in rats.
17-Allylamino-17-demethoxygeldanamycin-induced Changes in [(18)F]Fluorothymidine Uptake.
3'-deoxy-3'-[(18) F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: A pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response.
3'-Deoxy-3'-[18F]fluorothymidine positron emission tomography imaging of thymidine kinase 1 activity after 5-fluorouracil treatment in a mouse tumor model.
5-azacytidine induction of thymidine kinase in a spontaneously enzyme-deficient murine tumor line.
5-Fluoro-1-(2'-deoxy-2'-fluoro-beta-D-ribofuranosyl) uracil trapping in Morris hepatoma cells expressing the herpes simplex virus thymidine kinase gene.
5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase.
5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression.
8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET.
A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect.
A clinical evaluation of the TK 210 ELISA in sera from breast cancer patients demonstrates high sensitivity and specificity in all stages of disease.
A combined gene delivery by co-transduction of adenoviral and retroviral vectors for cancer gene therapy.
A comparative study: immunohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer.
A guanylate kinase/HSV-1 thymidine kinase fusion protein enhances prodrug-mediated cell killing.
A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer.
A meta-analysis of serological thymidine kinase 1 as a marker for colorectal benign and malignant tumor risk assessment.
A minimum c-erbB-2 promoter-mediated expression of herpes simplex virus thymidine kinase gene confers selective cytotoxicity of human breast cancer cells to ganciclovir.
A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography.
A monoclonal antibody specific for human thymidine kinase 1.
A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography.
A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs.
A new cell proliferating marker: cytosolic thymidine kinase as compared to proliferating cell nuclear antigen in patients with colorectal carcinoma.
A new oncolytic Vacciniavirus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery.
A New Sandwich ELISA for Quantification of Thymidine Kinase 1 Protein Levels in Sera from Dogs with Different Malignancies Can Aid in Disease Management.
A nomogram to predict individual prognosis in node-negative breast carcinoma.
A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy.
A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group.
A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies.
A phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients.
A phase I/II dose-escalation study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for metastatic melanoma. Study Group on Gene Therapy of Metastatic Melanoma.
A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma.
A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging.
A role for MAP kinase in the antitumor activity of a nucleoside analog.
A simple quantitative assay for the activity of thymidine kinase 1 in solid tumors.
A simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy.
A site of action for zinc in neoplastic tissue.
A tumor suppressor gene, Cx26, also mediates the bystander effect in HeLa cells.
Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T lymphoma.
Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.
Activities of various enzymes of pyrimidine nucleotide and DNA syntheses in normal and neoplastic human tissues.
Activity of the cytosolic isozyme of thymidine kinase in human primary lung tumors with reference to malignancy.
Activity of thymidilate "salvage pathway" enzymes in human gastric cancer and blood serum: correlation with treatment modalities.
Additional effects of medroxyprogesterone acetate on mammary tumors in oophorectomized, estrogenized, DMBA-treated rats.
Additive effects of medroxyprogesterone acetate and 5-fluorouracil derivative on 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors.
Adenoviral herpes simplex virus thymidine kinase gene therapy in an orthotopic lung cancer model.
Adenoviral insulinoma-associated protein 1 promoter-driven suicide gene therapy with enhanced selectivity for treatment of neuroendocrine cancers.
Adenoviral transduction of a cytosine deaminase/thymidine kinase fusion gene into prostate carcinoma cells enhances prodrug and radiation sensitivity.
Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer.
Adenoviral-delivered HE4-HSV-tk sensitizes ovarian cancer cells to ganciclovir.
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors.
Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies.
Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells.
Adenovirus E1a protein enhances the cytotoxic effects of the herpes thymidine kinase-ganciclovir system.
Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration.
Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome.
Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model.
Adenovirus-mediated gene therapy of experimental gliomas.
Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression.
Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing.
Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma.
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma.
Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity.
Adenovirus-mediated thymidine kinase gene therapy for recurrent ovarian cancer: expression of coxsackie-adenovirus receptor and integrins alphavbeta3 and alphavbeta5.
Adjuvant adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of liver transplantation in patients with advanced hepatocellular carcinoma.
Adjuvant interleukin-12 gene therapy for the management of colorectal liver metastases.
Allium sativum potentiates suicide gene therapy for murine transitional cell carcinoma.
alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil.
Amino acid metabolizing enzymes in rat submaxillary gland, normal or neoplastic, and in pancreas.
An adenovirus vector containing the suicide gene thymidine kinase for a broad application in cancer gene therapy.
An autologous in situ tumor vaccination approach for hepatocellular carcinoma. 1. Flt3 ligand gene transfer increases antitumor effects of a radio-inducible suicide gene therapy in an ectopic tumor model.
An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation.
Anti-tumor immunity is involved in the thymidine kinase-mediated killing of tumors induced by activated Ki-ras(G12V).
Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models.
Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways.
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Application of an in vitro assay for serum thymidine kinase: results on viral disease and malignancies in humans.
Applying the herpes simplex virus thymidine kinase/ganciclovir approach to ovarian cancer: an effective in vitro drug-sensitization system.
Approaches to utilize mesenchymal progenitor cells as cellular vehicles.
Aptamer-Based Sandwich Assay for Measurement of Thymidine Kinase 1 in Serum of Cancerous Patients.
Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene.
AroCell TK 210 ELISA for determination of TK1 protein: age-related reference ranges and comparison with other TK1 assays.
Assays for noninvasive imaging of reporter gene expression.
Assessment of ?-Fetoprotein Targeted HSV1-tk Expression in Hepatocellular Carcinoma with In Vivo Imaging.
Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach.
Assessment of drug-induced dysregulations among seven resistance-associated genes in human tumour cell lines.
Assignment of the integration site for simian virus 40 to chromosome 17 in GM54VA, a human cell line transformed by simian virus 40.
Assignment of Tp53 and Tk1 to chromosome 13 in Peromyscus by fluorescence in situ hybridization.
AV.TK-mediated killing of subcutaneous tumors in situ results in effective immunization against established secondary intracranial tumor deposits.
Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy.
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.
B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.
Basic peptide system for efficient delivery of foreign genes.
Basis of FLT as a cell proliferation marker: comparative uptake studies with [3H]thymidine and [3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines.
Biochemical changes in premalignant intestines.
Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines.
Biochemical modulation of 5-fluorouracil with a streptococcal preparation, OK-432, against murine colon-26 carcinoma.
Biochemical modulation of 5-fluorouracil with interferon alpha/beta and gamma on murine renal cell carcinoma.
Biochemical modulation of 5-fluorouracil with murine interferon-alpha/beta against murine renal cell carcinoma.
Biochemical modulation of tumor cell energy: regression of advanced spontaneous murine breast tumors with a 5-fluorouracil-containing drug combination.
Biochemical tissue markers of human colorectal carcinoma.
Biological heterogeneity of ER-positive breast cancers in the post-menopausal population.
Bioluminescence imaging of a tumor-selective, thymidine kinase-defective vaccinia virus Guang9 strain after intratumoral or intraperitoneal administration in mice.
Biomedical applications of nanoflares: Targeted intracellular fluorescence probes.
Biomimetic cell membrane-coated DNA nanoparticles for gene delivery to glioblastoma.
Bone metastasis imaging with SPECT/CT/MRI: A preclinical toolbox for therapy studies.
Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors.
Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues.
Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.
Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.
c-erbB-2/c-erbA co-amplification indicative of lymph node metastasis, and c-myc amplification of high tumour grade, in human breast carcinoma.
cAMP stimulates the bystander effect in suicide gene therapy of human choriocarcinoma.
Can thymidine kinase levels in breast tumors predict disease recurrence?
Cancer Cell Targeting with Mouse TERT-Specific Group I Intron of Tetrahymena thermophila.
Cancer gene therapy by direct tumor injections of a nonviral T7 vector encoding a thymidine kinase gene.
Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated immune responses and causes apoptotic death of tumor cells in vivo.
Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control.
Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse experimental glioma models.
Cationic liposomes enhance retrovirus-mediated multinucleated cell formation and retroviral transduction.
Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells.
Cell cycle related studies on thymidine kinase and its isoenzymes in Ehrlich ascites tumours.
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Cell-specific targeting of a thymidine kinase/ganciclovir gene therapy system using a recombinant Sindbis virus vector.
Cell-specific viral gene therapy of a Hurthle cell tumor.
Cells producing recombinant retrovirus with thymidine kinase gene from Herpes simplex virus suitable for human cancer gene therapy.
Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK.
Changes in serum thymidine kinase 1 levels during chemotherapy correlate with objective response in patients with advanced gastric cancer.
Changes of serum thymidine kinase in children with acute leukemia.
Changes of thymidine kinase (TK) during adjuvant and palliative chemotherapy.
Changes of tumor vascularity during gene therapy monitored with color Doppler US.
Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity.
Characterization of HIV-1 TAT peptide as an enhancer of HSV-TK/GCV cancer gene therapy.
Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1.
Characterization of the purified cytosolic thymidine kinase from murine ehrlich ascites tumor: interconversion of two different relative molecular weight forms.
Characterization of three essential residues in the conserved ATP-binding region of Epstein-Barr virus thymidine kinase.
Charge dependent substrate activity of C3' and N3 functionalized, organometallic technetium and rhenium-labeled thymidine derivatives toward human thymidine kinase 1.
Chemoprevention of cancer by organoselenium compounds.
Chronic lymphocytic leukemia: novel prognostic factors and their relevance for risk-adapted therapeutic strategies.
Circadian variations of interleukin-2 receptors, serum thymidine kinase and beta-2-microglobulin in patients with non-Hodgkin's lymphoma and normal controls.
Circulating Biomarkers of CDK4/6 Inhibitors Response in Hormone Receptor Positive and HER2 Negative Breast Cancer.
Circulating tumor M2 pyruvate kinase and thymidine kinase 1 are potential predictors for disease recurrence in renal cell carcinoma after nephrectomy.
CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.
Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes.
Clinical relevance of thymidine kinase for the diagnosis, therapy monitoring and prognosis of non-operable lung cancer.
Clinical significance of circulating CD44 in non-Hodgkin's lymphoma.
Clinical significance of thymidine kinase in Egyptian children with acute lymphoblastic leukemia.
Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth.
Co-transduction of herpes simplex virus thymidine kinase gene and human interleukin-2 gene into mouse ovarian cancer cell line, OVHM.
Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice.
Combination effect of oncolytic adenovirus therapy and herpes simplex virus thymidine kinase/ganciclovir in hepatic carcinoma animal models.
Combination electro-gene therapy using herpes virus thymidine kinase and interleukin-12 expression plasmids is highly efficient against murine carcinomas in vivo.
Combination gene therapy for liver metastasis of colon carcinoma in vivo.
Combination gene therapy for salivary gland cancer.
Combination gene therapy of lung cancer with conditionally replicating adenovirus and adenovirus-herpes simplex virus thymidine kinase.
Combination of cytokine-enhanced vaccine and chemo-gene therapy as surgery adjuvant treatments for spontaneous canine melanoma.
Combination of pet imaging with viral vectors for identification of cancer metastases.
Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival.
Combine cancer gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and Herpes simplex thymidine kinase suicide gene.
Combined radionuclide-chemotherapy and in vivo imaging of hepatocellular carcinoma cells after transfection of a triple-gene construct, NIS, HSV1-sr39tk, and EGFP.
Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors.
Combining Small Interfering RNAs Targeting Thymidylate Synthase and Thymidine Kinase 1 or 2 Sensitizes Human Tumor Cells to 5-Fluorodeoxyuridine and Pemetrexed.
Comparative aspects of the proliferation marker thymidine kinase 1 in human and canine tumour diseases.
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
Comparison of different methods to assess the cytotoxic effects of cytosine deaminase and thymidine kinase gene therapy.
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression.
Competitive binding radioassay for the determination of 5-fluorodeoxyuridine and 5-fluorodeoxyuridine-5'-monophosphate levels in plasma and tumor tissue.
Complete cure of established murine hepatocellular carcinoma is achievable by repeated injections of retroviruses carrying the herpes simplex virus thymidine kinase gene.
Complete regression of metastatic de-differentiated liposarcoma with engineered mesenchymal stromal cells with dTRAIL and HSV-TK.
Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity.
Concerted stimulation of transcription by glucocorticoid receptors and basal transcription factors: limited transcriptional synergism suggests mediation by coactivators/adaptors.
Configurations of a two-tiered amplified gene expression system in adenoviral vectors designed to improve the specificity of in vivo prostate cancer imaging.
Connexin 43 SUMOylation improves gap junction functions between liver cancer stem cells and enhances their sensitivity to HSVtk/GCV.
Connexin 43-enhanced suicide gene therapy using herpesviral vectors.
Connexin 43-mediated bystander effect in two rat glioma cell models.
Connexin-independent ganciclovir-mediated killing conferred on bystander effect-resistant cell lines by a herpes simplex virus-thymidine kinase-expressing colon cell line.
Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities.
Constitutive overexpression of DNA binding activity to the distal CCAAT box of human thymidine kinase promoter in human tumor cell lines.
Construction and identification of recombinant vectors carrying herpes simplex virus thymidine kinase and cytokine genes expressed in gastric carcinoma cell line SGC7901.
Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: reversal of hepatocyte immortalization by site-specific excision of the SV40 T antigen.
Contribution of a combination of ponicidin and acyclovir/ganciclovir to the antitumor efficacy of the herpes simplex virus thymidine kinase gene therapy system.
Control of Ehrlich cell division by zinc.
Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus.
Correction to: Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies.
Correlation between tumor proliferation and serum levels of beta 2-microglobulin and thymidine kinase in malignant lymphomas.
Correlation of 18F-FLT uptake with equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in gastrointestinal cancer.
Correlation of glucocorticoid receptor binding sites on MMTV proviral DNA with hormone inducible transcription.
Correlations of (18)F-fluorothymidine uptake with pathological tumour size, Ki-67 and thymidine kinase 1 expressions in primary and metastatic lymph node colorectal cancer foci.
Cotargeting tumor and stroma in a novel chimeric tumor model involving the growth of both human prostate cancer and bone stromal cells.
Cowpox Virus: A New and Armed Oncolytic Poxvirus.
Cre/loxP system controlled by specific promoter for radiation-mediated gene therapy of hepatoma.
Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.
Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma.
Cure of mice with established metastatic friend leukemia cell tumors by a combined therapy with tumor cells expressing both interferon-alpha 1 and herpes simplex thymidine kinase followed by ganciclovir.
Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy.
Cytosolic thymidine kinase is a specific histopathologic tumour marker for breast carcinomas.
Cytotoxicity and antiangiogenesis by fibroblast growth factor 2-targeted Ad-TK cancer gene therapy.
Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells.
Deletion of Apoptosis Inhibitor F1L in Vaccinia Virus Increases Safety and Oncolysis for Cancer Therapy.
Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics.
Deoxycytidine and deoxythymidine kinase activities in plasma of mice and patients with neoplastic disease.
Depicting Changes in Tumor Biology in Response to Cetuximab Monotherapy or Combination Therapy by Apoptosis and Proliferation Imaging Using 18F-ICMT-11 and 18F-FLT PET.
Derivation of a triple mosaic adenovirus for cancer gene therapy.
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
Development of (18)F-labeled PET probes for imaging cell proliferation.
Development of anti-tumor immunity against a non-immunogenic mammary carcinoma through in vivo somatic GM-CSF, IL-2, and HSVtk combination gene therapy.
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.
Development of Systemic Immunologic Responses Against Hepatic Metastases During Gene Therapy for Peritoneal Carcinomatosis With Retroviral HS-tk and Ganciclovir.
Diagnostic and Prognostic Value of Serum Thymidine Kinase 1 in Cancer Patients.
Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.
Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells.
Different regulation of the human thymidine kinase promoter in normal human diploid IMR-90 fibroblasts and HeLa cells.
Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells.
Differential chemosensitivity of breast cancer cells to ganciclovir treatment following adenovirus-mediated herpes simplex virus thymidine kinase gene transfer.
Differential expression of thymidine kinase gene in two subpopulations of a rat tumour correlates with their tumorigenic and cell division potential.
Differential ganciclovir-mediated cell killing by glutamine 125 mutants of herpes simplex virus type 1 thymidine kinase.
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy.
Direct evidence for the absence of intercellular trafficking of VP22 fused to GFP or to the herpes simplex virus thymidine kinase.
Direct intratumoral gene transfer of the herpes simplex virus thymidine kinase gene with DNA-liposome complexes: growth inhibition of tumors and lack of localization in normal tissues.
Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage.
DNA synthesis in tumor-bearing rats.
DNA-liposome complexes transduction of herpes simplex virus thymidine kinase renders human tongue cancer cell line sensitive to ganciclovir in vitro.
Do there exist synergistic antitumor effects by coexpression of herpes simplex virus thymidine kinase with cytokine genes on human gastric cancer cell line SGC7901?
Dual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging.
E1A RNA transcripts amplify adenovirus-mediated tumor reduction.
Early prediction of pathologic response to neoadjuvant treatment of breast cancer: use of a cell-loss metric based on serum thymidine kinase 1 and tumour volume.
Effect of 5-fluorouracil on the release of thymidine kinase from hepatoma cells in vitro.
Effect of adenosine3', 5'-monophosphate on thymidine kinase in tumor cells.
Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect".
Effect of hyperthermia on thymidine salvage as related to DNA synthesis.
Effect of methylation on expression of microinjected genes.
Effect of NK cell immunotherapy on immune function in patients with hepatic carcinoma: A preliminary clinical study.
Effect of p53 activation on cell growth, thymidine kinase-1 activity, and 3'-deoxy-3'fluorothymidine uptake.
Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis.
Effect of suicide gene therapy in combination with immunotherapy on antitumour immune response & tumour regression in a xenograft mouse model for head & neck squamous cell carcinoma.
Effect of thymidine and thymidylate analogs on nucleic acid synthesis in tumor cells.
Effect on substrate binding of an alteration at the conserved aspartic acid-162 in herpes simplex virus type 1 thymidine kinase.
Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration.
Effects of beta-carotene-rich algae Dunaliella bardawil on the dynamic changes of normal and neoplastic mammary cells and general metabolism in mice.
Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice.
Effects of danazol on proliferation and viability of 7,12-dimethylbenz(a)anthracene-induced mammary tumours in rats.
Effects of estrogen and prolactin on thymidine kinase isozyme activities in DMBA-induced rat mammary tumor.
Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats.
Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging.
Effects of tamoxifen on mammary tumors and bone in 7,12-dimethylbenz-(a)anthracene-treated rats.
Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-? and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line.
Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model.
Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model.
Efficacy of lentivirus-mediated and MUC1 antibody-targeted VP22-TK/GCV suicide gene therapy for ovarian cancer.
Efficacy of repeated adenoviral suicide gene therapy in a localized murine tumor model.
Efficient suicide gene therapy of transduced and distant untransduced ovary tumors is correlated with significant increase of intratumoral T and NK cells.
Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model.
Elevated serum and mononuclear leukocyte thymidine kinase activities in patients with cancer.
Elevated serum thymidine kinase 1 predicts risk of pre/early cancerous progression.
Elimination of SOX2/OCT4-Associated Prostate Cancer Stem Cells Blocks Tumor Development and Enhances Therapeutic Response.
Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons.
Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase.
Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase.
Enhanced efficiency and specificity of ovarian cancer gene therapy in rats with a novel nonviral gene delivery system (GE7) via intraovarian artery perfusion approach.
Enhanced expression of thymidine kinase in human cells following ionizing radiation.
Enhanced ganciclovir killing and bystander effect of human tumor cells transduced with a retroviral vector carrying a herpes simplex virus thymidine kinase gene mutant.
Enhanced HIV-1 envelope-tumor protection by a recombinant vaccinia virus expressing anchored HIV-1 gp120 lacking gp41.
Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene.
Enhanced tumor cell killing in the presence of ganciclovir by herpes simplex virus type 1 vector-directed coexpression of human tumor necrosis factor-alpha and herpes simplex virus thymidine kinase.
Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator.
Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant.
Enhancement of tumor killing using a combination of tumor immunization and HSV-tk suicide gene therapy.
Enhancing effect of tumor promoters, phorbol esters and teleocidins on nuclear receptor-mediated transcription.
Entrapment of retroviral vector producer cells in three-dimensional alginate scaffolds for potential use in cancer gene therapy.
Enzyme kinetics of thymidine kinase isoenzymes of Ehrlich ascites tumour.
Enzyme pathology and the histologic categorization of human lung tumors: the continuum of quantitative biochemical indices of neoplasticity.
EORTC receptor and biomarker study group report analytical and technical evaluation of a thymidine kinase radio-enzymatic assay in breast cancer cytosols.
Epstein Barr virus-associated lymphoproliferative diseases: the virus as a therapeutic target.
Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma.
ERK-dependent suicide gene therapy for selective targeting of RTK/RAS-driven cancers.
Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging.
Establishment of parameters for optimal transduction efficiency and antitumor effects with purified high-titer HSV-TK retroviral vector in established solid tumors.
Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma.
Evaluation of an E1E4-deleted adenovirus expressing the herpes simplex thymidine kinase suicide gene in cancer gene therapy.
Evaluation of Arginine Deiminase Treatment in Melanoma Xenografts Using (18)F-FLT PET.
Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis.
Evaluation of herpes simplex virus 1 thymidine kinase-mediated trapping of (131)I FIAU and prodrug activation of ganciclovir as a synergistic cancer radio/chemotherapy.
Evaluation of human thymidine kinase 1 substrates as new candidates for boron neutron capture therapy.
Evaluation of prodrugs ability to induce effective ablation of cells transduced with viral thymidine kinase gene.
Evaluation of scopadulciol-related molecules for their stimulatory effect on the cytotoxicity of acyclovir and ganciclovir against Herpes simplex virus type 1 thymidine kinase gene-transfected HeLa cells.
Evaluation of Tumor Markers and Their Impact on Prognosis in Gallbladder, Bile Duct and Cholangiocellular Carcinomas - A Pilot Study.
Evaluation of Tumor Specificity and Immunity of Thymidine Kinase-Deleted Vaccinia Virus Guang9 Strain.
Evaluation of tumour markers as differential diagnostic tool in patients with suspicion of liver metastases from breast cancer.
Evaluation of [(18)F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer.
Exogenous p53 and ASPP2 expression enhances rAdV-TK/ GCV-induced death in hepatocellular carcinoma cells lacking functional p53.
Experimental therapy of allogeneic solid tumors induced in athymic mice with suicide gene-transducing replication-competent foamy virus vectors.
Exposed proliferation antigen 210 (XPA-210) in renal cell carcinoma (RCC) and oncocytoma: clinical utility and biological implications.
Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene.
Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity.
Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing.
Expression of thymidine kinase driven by an endothelial-specific promoter inhibits tumor growth of Lewis lung carcinoma cells in transgenic mice.
FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.
Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice.
FLT-PET may not be a reliable indicator of therapeutic response in p53-null malignancy.
Foamy virus vectors for suicide gene therapy.
Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model.
Foetal thymidine kinase in tumours and colonic flat mucosa of man.
Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancer.
Fusion enzymes containing HSV-1 thymidine kinase mutants and guanylate kinase enhance prodrug sensitivity in vitro and in vivo.
Fusion of the Human Immunodeficiency Virus Type 1 Tat Protein Transduction Domain to Thymidine Kinase Increases Bystander Effect and Induces Enhanced Tumor Killing In Vivo.
Fusion of the human immunodeficiency virus type 1 tat protein transduction domain to thymidine kinase increases bystander effect and induces enhanced tumor killing in vivo.
Gamma-rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk/ganciclovir on cancer cells.
Ganciclovir chemoablation of herpes thymidine kinase suicide gene-modified tumors produces tumor necrosis and induces systemic immune responses.
Ganciclovir-induced ablation non-proliferating thyrocytes expressing herpesvirus thymidine kinase occurs by p53-independent apoptosis.
Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase gene.
Gap junctions in human glioblastomas: implications for suicide gene therapy.
Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.
Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo.
Gene dosage and expression, and enzyme activity of thymidine kinase and thymidylate synthase in xenografted colorectal adenocarcinomas.
Gene expression patterns and tumor uptake of 18F-FDG, 18F-FLT, and 18F-FEC in PET/MRI of an orthotopic mouse xenotransplantation model of pancreatic cancer.
Gene Targeting to Hepatomas (AFP).
Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase.
Gene therapy for brain tumors.
Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.
Gene therapy for colon cancer with the herpes simplex thymidine kinase gene.
Gene therapy for endometrial carcinoma with the herpes simplex thymidine kinase gene.
Gene therapy for glioblastoma [correction of gliobestome] multiform: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir.
Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene.
Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector.
Gene therapy for lung cancer.
Gene therapy for malignant mesothelioma: a novel approach for an incurable cancer with increased incidence in Louisiana.
Gene therapy for malignant mesothelioma: beyond the infant years.
Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir.
Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
Gene therapy in brain tumours: implications of the size of glioblastoma on its curability.
Gene therapy of carcinoma using ultrasound-targeted microbubble destruction.
Gene therapy of epithelial ovarian cancer using adenoviral vectors.
Gene therapy of established medullary thyroid carcinoma with herpes simplex viral thymidine kinase in a rat tumor model: relationship of bystander effect and antitumor efficacy.
Gene therapy of liver tumors with human liver-specific nanoparticles.
Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells.
Gene therapy of neoplastic meningosis.
Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection.
Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer.
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-?B signaling improves the efficacy of immunotherapy in a brain cancer model.
Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression.
Genetic and biochemical modulation of 5-fluorouracil through the overexpression of thymidine kinase: an in-vitro study.
Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts.
Glial tumor cells deficient in thymidine kinase: isolation and characterization.
Glioblastoma Bystander Cell Therapy: Improvements in Treatment and Insights into the Therapy Mechanisms.
Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells.
Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice.
Glucose transport and apoptosis after gene therapy with HSV thymidine kinase.
GM-CSF raises serum levels of beta 2-microglobulin and thymidine kinase in patients with chronic lymphocytic leukaemia.
Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment.
Granulocyte-macrophage colony-stimulating factor in a combination gene therapy strategy for head and neck cancer.
Graphene oxide-hydroxyapatite nanocomposites effectively deliver HSV-TK suicide gene to inhibit human breast cancer growth.
Herpes simplex thymidine kinase gene transfer is required for complete regression of murine colon adenocarcinoma.
Herpes simplex virus thymidine kinase as a marker/reporter gene for PET imaging of gene therapy.
Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells.
Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells.
Herpes simplex virus thymidine kinase/ganciclovir-mediated killing of tumor cell induces tumor-specific cytotoxic T cells in mice.
Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing.
Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines.
Herpes vector-mediated delivery of marker genes to disseminated central nervous system tumors.
High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma.
High levels of inactive thymidine kinase 1 polypeptide detected in sera from dogs with solid tumours by immunoaffinity methods: Implications for in vitro diagnostics.
High Mobility Group Box2 Promoter-controlled Suicide Gene Expression Enables Targeted Glioblastoma Treatment.
High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma.
High-intensity focused ultrasound combined with herpes simplex virus thymidine kinase gene-loaded ultrasound-targeted microbubbles improved survival of rabbit with VX2 liver tumor.
High-level transgene expression mediated by the piggyBac transposon enhances transgenic therapeutic effects in cervical cancer xenografts.
Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene.
Histologic, biochemical, and clinical parameters for monitoring multiple myeloma.
Histone acetylation influences thyroid hormone and retinoic acid-mediated gene expression.
HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
Homogeneous assay for real-time and simultaneous detection of thymidine kinase 1 and deoxycytidine kinase activities.
Hormonal effects on thymidine kinase and thymidylate kinase activity of estrogen-dependent tumors in the rat.
Hormonal induction of transfected genes depends on DNA topology.
HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma.
HSV-1 viral oncolysis and molecular imaging with PET.
HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells.
HSV-TK/GCV cancer suicide gene therapy by a designed recombinant multifunctional vector.
HSVtk/GCV system on hepatoma carcinoma cells: Construction of the plasmid pcDNA3.1?pAFP-TK and targeted killing effect.
Human adipose tissue-derived mesenchymal stromal cells as vehicles for tumor bystander effect: a model based on bioluminescence imaging.
HVJ-liposome-mediated transfection of HSVtk gene driven by AFP promoter inhibits hepatic tumor growth of hepatocellular carcinoma in SCID mice.
Hypoxia/hepatoma dual specific suicide gene expression plasmid delivery using bio-reducible polymer for hepatocellular carcinoma therapy.
Identification and characterization of the conserved nucleoside-binding sites in the Epstein-Barr virus thymidine kinase.
Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.
Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo.
Imaging Chemically Modified Adenovirus for Targeting Tumors Expressing Integrin {alpha}v{beta}3 in Living Mice with Mutant Herpes Simplex Virus Type 1 Thymidine Kinase PET Reporter Gene.
Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I]FIAU and PET.
Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.
Imaging Metformin Efficacy as Add-On Therapy in Cells and Mouse Models of Human EGFR Glioblastoma.
Imaging of cellular proliferation in liver metastasis by [18F]fluorothymidine positron emission tomography: effect of therapy.
Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats.
Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.
Imaging the expression of transfected genes in vivo.
Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis.
Immunogene approach toward cancer therapy using erythrocyte growth factor receptor-mediated gene delivery.
Immunogenic Human Papillomavirus Pseudovirus-Mediated Suicide-Gene Therapy for Bladder Cancer.
Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer.
Immunomodulation of glioma cells after gene therapy: induction of major histocompatibility complex class I but not class II antigen in vitro.
Improvement of nonviral gene therapy by Epstein-Barr virus (EBV)-based plasmid vectors.
In situ gene transfer and suicide gene therapy of gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine in dogs.
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.
In situ use of suicide genes for cancer therapy.
In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma.
In vitro evaluation of mutant HSV-1 thymidine kinases for suicide gene therapy.
In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy.
In vitro mammalian mutagenesis as a model for genetic lesions in human cancer.
In vitro thymidine kinase/ganciclovir-based suicide gene therapy using replication defective herpes simplex virus-1 against leukemic B-cell malignancies (MCL, HCL, B-CLL).
In vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine kinase gene.
In vivo adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing pancreatic cancer.
In vivo comparison of IVDU and IVFRU in HSV1-TK gene expressing tumor bearing rats.
In vivo efficacy of folate-targeted lipid-protamine-DNA (LPD-PEG-Folate) complexes in an immunocompetent syngeneic model for breast adenocarcinoma.
In vivo evaluation of 2'-deoxy-2'-[(18)F]fluoro-5-iodo-1-beta-D-arabinofuranosyluracil ([18F]FIAU) and 2'-deoxy-2'-[18F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ([18F]FEAU) as markers for suicide gene expression.
In vivo gene delivery to tumor cells by transferrin-streptavidin-DNA conjugate.
In vivo Imaging of the Therapeutic Efficacy and Fate of Bimodal Engineered Stem Cells in Malignant Brain Tumors.
In vivo profiling of estrogen receptor/specificity protein-dependent transactivation.
In vivo reprogramming of human telomerase reverse transcriptase (hTERT) by trans-splicing ribozyme to target tumor cells.
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
In vivo surgical resection plus adjuvant gene therapy in the treatment of mammary and prostate cancer.
In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors.
Inclusion of the herpes simplex thymidine kinase gene in a replicating adenovirus does not augment antitumor efficacy.
Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells.
Increased activities of thymidine kinase isozymes in human mammary tumours.
Increased activities of thymidylate synthetase and thymidine kinase in human thyroid tumors.
Increased activity of thymidine kinase isozyme in human colon tumor.
Increased anti-tumor effect by a combination of HSV thymidine kinase suicide gene therapy and interferon-gamma/GM-CSF cytokine gene therapy in CT26 tumor model.
Increased efficiency of cisplatin-resistant cell lines to DNA-mediated gene transfer with cationic liposome.
Increased intratumoral fluorothymidine uptake levels following multikinase inhibitor sorafenib treatment in a human renal cell carcinoma xenograft model.
Increased serum level of thymidine kinase 1 correlates with metastatic site in patients with malignant melanoma.
INCREASED STABILITY OF TEMPLATES FOR SOME ENZYMES OF DNA SYNTHESIS IN TUMORS: DEOXYCYTIDYLATE DEAMINASE, THYMIDINE AND THYMIDYLATE KINASE.
Inducible expression of herpes simplex virus thymidine kinase increases sensitivity to ganciclovir but does not enhance bystander effect in breast cancer cells.
Induction of ornithine decarboxylase, tyrosine aminotransferase, and thymidine kinase by glucocorticoid in isolated, perfused liver after tumor inoculation.
Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies.
Induction of thymidine kinase activity in a spontaneously enzyme-deficient murine tumor cell line by exposure in vivo to the DNA-hypomethylating agent 5-aza-2'-deoxycytidine: implications for mechanisms of tumor progression.
Influence of different promoters on the expression of tumor-necrosis-factor-alpha in ls174t human colon-carcinoma cells.
Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter.
Inhibition of rat hepatocellular carcinoma tumor growth after multiple infusions of recombinant Ad.AFPtk followed by ganciclovir treatment.
Inhibition of thymidine kinase in cultured mammary tumor cells by the chemopreventive organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.
Inhibition of tumor growth by direct intratumoral gene transfer of herpes simplex virus thymidine kinase gene with DNA-liposome complexes.
Inhibition of tumor growth in liver epithelial cells transfected with a transforming growth factor alpha antisense gene.
Inhibitory effect of lignin-related pine cone extract on cell proliferating enzyme activity of spontaneous mammary tumours in mice.
Innovative strategies for the treatment of thyroid cancer.
INSM1 Promoter-Driven Adenoviral Herpes Simplex Virus Thymidine Kinase Cancer Gene Therapy for the Treatment of Primitive Neuroectodermal Tumors.
Interleukin-2 as a modulator of 5-fluorouracil in hepatic arterial immunochemotherapy for liver metastases.
Intracellular localization and sustained prodrug cell killing activity of TAT-HSVTK fusion protein in hepatocelullar carcinoma cells.
Intracellular localization of Herpes simplex virus type 1 thymidine kinase fused to different fluorescent proteins depends on choice of fluorescent tag.
Intracerebral Administration of Autologous Mesenchymal Stem Cells as HSV-TK Gene Vehicle for Treatment of Glioblastoma Multiform: Safety and Feasibility Assessment.
Intrathecal gene therapy for malignant leptomeningeal neoplasia.
Intratumoral activation of cyclophosphamide by retroviral transfer of the cytochrome P450 2B1 in a pancreatic tumor model. Combination with the HSVtk/GCV system.
Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: results of a phase I clinical trial.
Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir.
Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy.
Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes.
Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.
Investigation on traditional medicines of Guarany Indio and studies on diterpenes from Scoparia dulcis.
Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase.
Journey of 2'-deoxy-2'-fluoro-5-methyl-1-?-D-arabinofuranosyluracil (FMAU): from Antiviral Drug to PET Imaging Agent.
Killing effect of the herpes simplex virus thymidine kinase/ganciclovir enzyme/prodrug system on human nasopharyngeal carcinoma cells.
Lack of correlation between thymidine kinase activity and changes of DNA synthesis with tumour age: an in vivo study in Ehrlich ascites tumour.
Leucovorin modulation of 5-iododeoxyuridine radiosensitization: a phase I study.
Limitations of retrovirus-mediated HSV-tk gene transfer to pulmonary adenocarcinoma cells in vitro and in vivo.
Limited efficacy of gene transfer in herpes simplex virus-thymidine kinase/ganciclovir gene therapy for brain tumors.
Liposomal encapsulation of ganciclovir enhances the efficacy of herpes simplex virus type 1 thymidine kinase suicide gene therapy against hepatic tumors in rats.
Liquid chromatography-tandem mass spectrometry method for quantification of thymidine kinase activity in human serum by monitoring the conversion of 3'-deoxy-3'-fluorothymidine to 3'-deoxy-3'-fluorothymidine monophosphate.
Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus.
Local inflammation and devascularization--in vivo mechanisms of the "bystander effect" in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma.
Long-term connexin-mediated bystander effect in highly tumorigenic human cells in vivo in herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment.
Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.
Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA.
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression.
Low-dose cisplatin converts the tumor microenvironment into a permissive state for HSVtk-induced antitumor immunity in HPV16-related tonsillar carcinoma.
Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment.
Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.
Mechanisms for ganciclovir resistance in gastrointestinal tumor cells transduced with a retroviral vector containing the herpes simplex virus thymidine kinase gene.
Mechanisms of the escape phase of myeloma.
Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells.
Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies.
Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells.
Microchip immunoaffinity electrophoresis of antibody-thymidine kinase 1 complex.
MicroPET imaging of prostate cancer in LNCAP-SR39TK-GFP mouse xenografts.
Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor.
Minicircles for a two-step blood biomarker and PET imaging early cancer detection strategy.
miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy.
miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy.
Modulation of 5-fluorouracil resistance in human colon tumor cell lines by azidothymidine.
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy.
Molecular imaging of brain tumors personal experience and review of the literature.
Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer.
Molecular PET and PET/CT imaging of tumour cell proliferation using F-18 fluoro-L-thymidine: a comprehensive evaluation.
Molecular-genetic PET imaging using an HSV1-tk mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs.
Monitoring of bystander effect of herpes simplex virus thymidine kinase/acyclovir system using fluorescence resonance energy transfer technique.
Monitoring of gliomas in vivo by diffusion MRI and (1)H MRS during gene therapy-induced apoptosis: interrelationships between water diffusion and mobile lipids.
Monitoring Response to Radiotherapy in Human Squamous Cell Cancer Bearing Nude Mice: Comparison of 2'-deoxy-2'-[(18)F]fluoro-D: -glucose (FDG) and 3'-[ (18)F]fluoro-3'-deoxythymidine (FLT).
Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.
MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma.
Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells.
Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033.
Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells.
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies.
Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a tri-fusion reporter gene.
Multiparametric prognostic evaluation of biological factors in primary breast cancer.
Multitracer studies during gene therapy of hepatoma cells with herpes simplex virus thymidine kinase and ganciclovir.
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
Muscle-invasive bladder cancer is characterized by overexpression of thymidine kinase 1.
Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats.
Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer.
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies.
Neoadjuvant Gene-Mediated Cytotoxic Immunotherapy for Non-Small-Cell Lung Cancer: Safety and Immunologic Activity.
Neuron-specific enolase and thymidine kinase as an aid to the diagnosis and treatment monitoring of small cell lung cancer.
NF-Y-mediated trans-activation of the human thymidine kinase promoter is closely linked to activation of cyclin-dependent kinase.
Non-invasive in vivo imaging with radiolabelled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir.
Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy model.
Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma.
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers.
Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells.
Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
Novel monoclonal antibodies against thymidine kinase 1 and their potential use for the immunotargeting of lung, breast and colon cancer cells.
Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity.
NT-polyplex: a new tool for therapeutic gene delivery to neuroblastoma tumors.
Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix.
Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the right inverted terminal repeat.
On the possible contribution of DNA hypomethylation to the induction of high frequency and heritable drug-induced alterations in the malignant phenotype.
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.
Oncolytic efficacy of thymidine kinase-deleted vaccinia virus strain Guang9.
Oncoselective parvoviral vector-mediated gene therapy of cancer.
Optimizing suicide gene therapy for head and neck cancer.
Osteonectin Promoter-Mediated Suicide Gene Therapy of Prostate Cancer.
Osteosarcoma and chondrosarcoma as targets for virus vectors and herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Ovarian Cancer Gene Therapy Using HPV-16 Pseudovirion Carrying the HSV-tk Gene.
Overproduction of the protein product of a nonselected foreign gene carried by an adenovirus vector.
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Papers to appear in forthcoming issues
Partial regression, yet incomplete eradication of mammary tumors in transgenic mice by retrovirally mediated HSVtk transfer 'in vivo'.
Patterns of DNA methylation and gene expression in human tumor cell lines.
Periodate-oxidized adenosine induction of murine thymidine kinase: role of DNA methylation in the generation of tumor cell heterogeneity.
PET imaging of herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk reporter gene expression in mice and humans using [18F]FHBG.
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside.
Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors.
Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer.
Phase IB Study of Gene-Mediated Cytotoxic Immunotherapy Adjuvant to Up-Front Surgery and Intensive Timing Radiation for Malignant Glioma.
Plasma and CSF pharmacokinetics of ganciclovir in nonhuman primates.
Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics.
Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.
Polyamine depletion and cell cycle manipulation in combination with HSV thymidine kinase/ganciclovir cancer gene therapy.
Polymeric Nanovectors Incorporated with Ganciclovir and HSV-tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy.
Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK.
Positron emission tomography of herpes simplex virus 1 oncolysis.
Potent tumor-specific immunity induced by an in vivo heat shock protein-suicide gene-based tumor vaccine.
Potential of bromovinyldeoxyuridine in anticancer chemotherapy.
Potential of gene therapy for the treatment of pituitary tumors.
Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin.
Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma.
Preclinical evaluation of the penciclovir analog 9-(4-[(18)F]fluoro-3-hydroxymethylbutyl)guanine for in vivo measurement of suicide gene expression with PET.
Preclinical studies on suicide gene therapy for head/neck cancer: a novel method for evaluation of treatment efficacy.
Preclinical testing of recombinant adenoviral herpes simplex virus-thymidine kinase gene therapy for central nervous system malignancies.
Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir.
Preservation of the bystander cytocidal effect of irradiated herpes simplex virus thymidine kinase (HSV-tk) modified tumor cells.
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Prodrug-activated gene therapy: involvement of an immunological component in the "bystander effect".
Production and characterization of a bicistronic Moloney-based retroviral vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for gene therapy of cancer.
Prognostic importance of thymidine kinase in colorectal and breast cancer.
Prognostic of DNA-synthesizing enzyme activities (thymidine kinase and thymidylate synthase) in 908 T1-T2, N0-N1, M0 breast cancers: a retrospective multicenter study.
Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy.
Prognostic significance of the receptor for epidermal growth factor in human mammary carcinomas.
Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors.
Prognostic value of cytosolic thymidine kinase activity as a marker of proliferation in breast cancer.
Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma.
Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy.
Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines.
Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker.
Properties of thymidine kinase partially purified from human adrenal glands.
Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755.
Protein synthesis and tumorigenicity of the cytoplasmic hybrid between rat yolk sac tumor and mouse fibroblastic cell line.
Pseudotyped retrovectors for tumor-specific delivery of toxic suicide genes.
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Purification of thymidine kinase activity from Yaba virus induced tumors.
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Purified herpes simplex virus thymidine kinase retroviral particles: III. Characterization of bystander killing mechanisms in transfected tumor cells.
Purkinje cell protein-2 cis-elements mediate repression of T3-dependent transcriptional activation.
Pyrimidine nucleosides in molecular PET imaging of tumor proliferation.
Pyrimidine nucleotide metabolism in human colon carcinomas: comparison of normal tissues, primary tumors and xenografts.
Quantifying the Activity of Adenoviral E1A CR2 Deletion Mutants Using Renilla Luciferase Bioluminescence and 3'-Deoxy-3'-[18F]Fluorothymidine Positron Emission Tomography Imaging.
Quantitative 1H nuclear magnetic resonance diffusion spectroscopy of BT4C rat glioma during thymidine kinase-mediated gene therapy in vivo: identification of apoptotic response.
Quantitative differences in androgen and glucocorticoid receptor DNA binding properties contribute to receptor-selective transcriptional regulation.
Radiolabeled nucleoside analogues for PET imaging of HSV1-tk gene expression.
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963.
Real-time visualizing and tracing of HSV-TK/GCV suicide gene therapy by near-infrared fluorescent quantum dots.
Recent developments in the prevention and treatment of Epstein-Barr virus-associated lymphoproliferative diseases.
Receptor-mediated gene delivery using the Fab fragments of anti-epidermal growth factor receptor antibodies: improved immunogene approach.
Recombinagenic activity of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human lymphoblastoid cells.
Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication.
Recombinant interferon alpha2a synergistically enhances ganciclovir-mediated tumor cell killing in the herpes simplex virus thymidine kinase system.
Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography.
Refined human artificial chromosome vectors for gene therapy and animal transgenesis.
Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy.
Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage.
Regulation of HSVtk gene by endogenous microRNA-122a in liver cell lines as suicide gene therapy.
Relative activities of thymidylate synthetase and thymidine kinase in human mammary tumours.
Relative activities of thymidylate synthetase and thymidine kinase in rat tissues.
Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy.
Remnant living cells that escape cell loss in late-stage tumors exhibit cancer stem cell-like characteristics.
Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy.
Reporter gene imaging: effects of ganciclovir treatment on nucleoside uptake, hypoxia and perfusion in a murine gene therapy tumour model that expresses herpes simplex type-1 thymidine kinase.
Research on application value of combined detection of serum CA125, HE4 and TK1 in the diagnosis of ovarian cancer.
Resistance developing after long-term ganciclovir prodrug treatment in a preclinical model of NSCLC.
Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir.
Retargeting of adenoviral vectors to neurons using the Hc fragment of tetanus toxin.
Retroviral transfer of HSV1-TK gene into human lung cancer cell line.
Reverse transcriptase and thymidine kinase as markers for tumorigenicity and viral contamination of cells.
Ribozyme-mediated selective killing of cancer cells expressing carcinoembryonic antigen RNA by targeted trans-splicing.
Role of thymidine kinase in the inhibitory activity of 5-substituted-2'-deoxyuridines on the growth of human and murine tumor cell lines.
Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer.
Secretion of thymidine kinase to increase the effectivity of suicide gene therapy results in the loss of enzymatic activity.
Sedimentation rate and serum thymidine kinase activity: prognostic factors in squamous cell head and neck cancer.
Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7.
Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene.
Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene.
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents.
Selective incorporation of iododeoxyuridine into DNA of hepatic metastases versus normal human liver.
Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene.
Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene.
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression.
Sensitive nonradiometric method for determining thymidine kinase 1 activity.
Sequential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
Serial evaluation of serum thymidine kinase activity is prognostic in women with newly diagnosed metastatic breast cancer.
Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir.
Serological thymidine kinase 1 (STK1) indicates an elevated risk for the development of malignant tumours.
Serological thymidine kinase 1 is a biomarker for early detection of tumours--a health screening study on 35,365 people, using a sensitive chemiluminescent dot blot assay.
Serum detection of thymidine kinase 1 as a means of early detection of lung cancer.
Serum soluble CD27, but not thymidine kinase, is an independent prognostic factor for outcome in indolent non-Hodgkin's lymphoma.
Serum thymidine kinase 1 activity in solid tumor (breast and colorectal cancer) patients treated with adjuvant chemotherapy.
Serum thymidine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease.
Serum thymidine kinase 1 correlates to clinical stages and clinical reactions and monitors the outcome of therapy of 1,247 cancer patients in routine clinical settings.
Serum thymidine kinase 1 is a reliable maker for the assessment of the risk of developing malignancy: A case report.
Serum thymidine kinase 1 is associated with Gleason score of patients with prostate carcinoma.
Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma.
Serum thymidine kinase 1 reflects the progression of pre-malignant and malignant tumors during therapy.
Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial.
Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma.
Serum thymidine kinase activity in clinically healthy and diseased horses: A potential marker for lymphoma.
Serum thymidine kinase activity in dogs with malignant lymphoma: a potent marker for prognosis and monitoring the disease.
Serum thymidine kinase as a marker of disease activity in patients with multiple myeloma.
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Serum thymidine kinase in colorectal neoplasia.
Serum thymidine kinase is associated with gastric adenocarcinoma.
Serum thymidine kinase levels in cancer patients.
Serum TK levels in CLL identify Binet stage A patients within biologically defined prognostic subgroups most likely to undergo disease progression.
Serum TK1 is a more reliable marker than CEA and AFP for cancer screening survey in a study of 56,286 people.
Serum tumour markers in human prostatic carcinoma. The value of a marker panel for prognostic information.
Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected lymphoma cells to nucleoside analogue antiviral agents.
Short-term neuropathological aspects of in vivo suicide gene transfer to the F98 rat glioblastoma using liposomal and viral vectors.
Silk-elastinlike protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck tumors.
Simultaneous evaluation of dual gene transfer to adherent cells by gamma-ray imaging.
Simultaneous imaging of temporal changes of NF-?B activity and viable tumor cells in Huh7/NF-?B-tk-luc2/rfp tumor-bearing mice.
siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine.
Small Animal PET Imaging of hTERT RNA-Targeted HSV1-tk Gene Expression with Trans-Splicing Ribozyme.
Some characteristics of fetal and adult isoenzymes of thymidine kinase in human breast cancers.
SP94-Targeted Triblock Copolymer Nanoparticle Delivers Thymidine Kinase-p53-Nitroreductase Triple Therapeutic Gene and Restores Anticancer Function against Hepatocellular Carcinoma in Vivo.
Specific recognition of cytosolic thymidine kinase in the human lung tumor by monoclonal antibodies raised against recombinant human thymidine kinase.
Specific regression of human cancer cells by ribozyme-mediated targeted replacement of tumor-specific transcript.
Specific viral antigens in rat cells transformed by herpes simplex virus type 2 and in rat tumors induced by inoculation of transformed cells.
SPECT imaging of herpes simplex virus type1 thymidine kinase gene expression by [(123)I]FIAU(1).
Stable transgenic expression of IL-2 and HSV1-tk by single and fusion tumor cell lines bearing EWS/FLI-1 chimeric genes.
STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy.
Strategies for gene therapy.
Suicide Gene Therapy Against Malignant Gliomas by the Local Delivery of Genetically Engineered Umbilical Cord Mesenchymal Stem Cells as Cellular Vehicles.
Suicide Gene Therapy for Oral Squamous Cell Carcinoma.
Suicide gene therapy for urogenital cancer: current outcome and prospects.
Suicide gene therapy of chemically induced mammary tumor in rat: efficacy and distant bystander effect.
Suicide gene therapy using adenovirus vector for human oral squamous carcinoma cell line in vitro.
Suicide gene therapy using reducible poly (oligo-D-arginine) for the treatment of spinal cord tumors.
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
Suppression of tumorigenesis and tumor-growth of mouse mammary-glands by a traditional chinese herbal medicine, sho-saiko-to.
Sustained release of low-dose ganciclovir from a silicone formulation prolonged the survival of rats with gliosarcomas under herpes simplex virus thymidine kinase suicide gene therapy.
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir-mediated cytoxicity by hydroxyurea.
Synergy between the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan.
Synergy of adoptive T-cell therapy and intratumoral suicide gene therapy is mediated by host NK cells.
Synthesis and application of poly(ethylene glycol)-co-poly(?-amino ester) copolymers for small cell lung cancer gene therapy.
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy.
Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer.
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.
Synthesis of 2-amino-6-(4-[11C]methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester as a novel potential PET gene reporter probe for HBV and HSV-tk in cancers.
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Synthesis of 5-radioiodoarabinosyl uridine analog for probing HSV-1 thymidine kinase gene: an unexpected chelating effect.
Synthesis of unnatural 7-substituted-1-(2-deoxy-beta-D-ribofuranosyl)isocarbostyrils: "thymine replacement" analogs of deoxythymidine for evaluation as antiviral and anticancer agents.
Synthesis, biological evaluation, and radioiodination of halogenated closo-carboranylthymidine analogues.
Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1.
Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes.
Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma.
Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy.
T cell suicide gene therapy to aid haematopoietic stem cell transplantation.
Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies.
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
Targeted gene therapy for cancer: herpes simplex virus thymidine kinase gene-mediated cell killing leads to anti-tumour immunity that can be augmented by co-expression of cytokines in the tumour cells.
Targeted in vivo delivery of therapeutic gene into experimental squamous cell carcinomas using anti-epidermal growth factor receptor antibody: immunogene approach.
Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors.
Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model.
Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.
Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene.
Technical evaluation of thymidine kinase assay in cytosols from breast cancers. EORTC Receptor Study Group Report.
Temporal changes in gene expression following cryogenic rat brain injury.
TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection.
Test of ovarian cancer multiplex xMAP technology panel.
The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.
The anti-tumor effect of human monocyte-derived dendritic cells loaded with HSV-TK/GCV induced dying cells.
The Association of Serum Carcinoembryonic Antigen, Carbohydrate Antigen 19-9, Thymidine Kinase, and Tissue Polypeptide Specific Antigen with Outcomes of Patients with Metastatic Colorectal Cancer Treated with Bevacizumab: a Retrospective Study.
The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions.
The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody.
The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects.
The Current State of Clinical Application of Serum Biomarkers for Canine Lymphoma.
The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.
The drug verapamil inhibits bystander killing but not cell suicide in thymidine kinase-ganciclovir prodrug-activated gene therapy.
The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
The effect of promoter strength in adenoviral vectors containing herpes simplex virus thymidine kinase on cancer gene therapy in vitro and in vivo.
The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats.
The EIIAPA Chimeric Promoter for Tumor Specific Gene Therapy of Hepatoma.
The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer.
The equine herpes virus 4 thymidine kinase is a better suicide gene than the human herpes virus 1 thymidine kinase.
The evaluation of adenoviral p53-mediated bystander effect in gene therapy of cancer.
The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.
The genome of canarypox virus.
The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models.
The inhibition of thymidine kinase in glial tumor cells by an amino sugar, D-glucosamine.
The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene.
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
The nanoparticulate Quillaja saponin KGI exerts anti-proliferative effects by down-regulation of cell cycle molecules in U937 and HL-60 human leukemia cells.
The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction.
The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers.
The presence of "fetal" thymidine kinase in human tumors.
The processed pseudogene of mouse thymidine kinase is active after transfection.
The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line.
The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy.
The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells.
The role of herpes simplex virus thymidine kinase in the treatment of solid tumours.
The role of herpes simplex virus-1 thymidine kinase alanine 168 in substrate specificity.
The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene.
The role of thymidine kinase activity in murine colon tumours treated with 5-fluorouracil.
The role of thymidine kinase in cancer diseases.
The study of different chromosomal aberrations, CD38 and ZAP-70 in chronic lymphocytic leukemia patients.
The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters.
The topoisomerase II-inhibitor NC-190 reduces the level of thymidine kinase mRNA in murine tumor cells.
The treatment of malignant mesothelioma with a gene modified cancer cell line: a phase I study.
The uptake of 3'-deoxy-3'-[(18)F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels.
The uptake of 3'-deoxy-3'-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels.
Theranostic Imaging of Cancer Gene Therapy.
Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.
Therapeutic potency of transduction with herpes simplex virus thymidine kinase gene against multidrug resistant mouse leukemia cells.
Thymidine kinase (TK) gene therapy of solid tumors: valacyclovir facilitates outpatient treatment.
Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis.
Thymidine kinase 1 as a tumor biomarker: technical advances offer new potential to an old biomarker.
Thymidine kinase 1 combined with CEA, CYFRA21-1 and NSE improved its diagnostic value for lung cancer.
Thymidine kinase 1 expression in atypical ductal hyperplasia significantly differs from usual ductal hyperplasia and ductal carcinoma in situ: A useful tool in tumor therapy management.
Thymidine kinase 1 expression in ovarian serous adenocarcinoma is superior to Ki-67: A new prognostic biomarker.
Thymidine kinase 1 through the ages: a comprehensive review.
Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study.
Thymidine kinase activity in serum of renal cell carcinoma patients is a useful prognostic marker.
Thymidine kinase and cancer monitoring.
Thymidine kinase and thymidine phosphorylase level as the main predictive parameter for sensitivity to TAS-102 in a mouse model.
Thymidine kinase as a predictor of response to chemotherapy in advanced breast cancer.
Thymidine kinase expression. A marker for malignant cells.
Thymidine Kinase Gene Modified Bone Marrow Mesenchymal Stem Cells as Vehicles for Anti-tumor Therapy.
Thymidine kinase in breast cancer.
Thymidine kinase in malignant melanoma.
Thymidine kinase is expressed differently in transformed versus normal-cells - a novel test for malignancy.
Thymidine kinase levels correlate with prognosis in aggressive lymphoma and can discriminate patients with a clinical suspicion of indolent to aggressive transformation.
Thymidine Kinase PET Reporter Gene Imaging of Cancer Cells In Vivo.
Thymidine Kinase Type 1 and C-Reactive Protein Concentrations in Dogs with Spontaneously Occurring Cancer.
Thymidine kinase, DNA synthesis and cancer.
Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.
Thymidine Kinase-1 as Additional Diagnostic Marker of Prostate Cancer.
Thymidine Kinase: A Biomarker for Recently Diagnosed Acute Leukemia in Pediatric Patients According to the Cell Line Involved.
Thymidine kinase: a tumor marker with prognostic value for non-Hodgkin's lymphoma and a broad range of potential clinical applications.
Thymidine kinase: diagnostic and prognostic potential.
Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo.
Thymidylate synthetase and thymidine kinase activities and methotrexate cytotoxicity during growth of L1210 and Ehrlich ascites tumor.
Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems.
Titration of Variant HSV1-tk Gene Expression to Determine the Sensitivity of 18F-FHBG PET Imaging in a Prostate Tumor.
Total vascular exclusion of the liver enhances the efficacy of retroviral-mediated associated thymidine kinase and interleukin-2 genes transfer against multiple hepatic tumors in rats.
Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.
Toxicity assessment of intratumoral injection of the herpes simplex type I thymidine kinase gene delivered by retrovirus in patients with refractory cancer.
Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors.
Tracing transgene expression in cancer gene therapy: a requirement for rational progress in the field.
Tracking cellular stress with labeled FMAU reflects changes in mitochondrial TK2.
Trans-complementing adenoviral vectors for oncolytic therapy of malignant melanoma.
Transcellular transfer of active HSV-1 thymidine kinase mediated by an 11-amino-acid peptide from HIV-1 Tat.
Transcription initiation of transfected mouse mammary tumor virus LTR DNA is regulated by glucocorticoid hormones.
Transcriptional targeting of acute hypoxia in the tumour stroma is a novel and viable strategy for cancer gene therapy.
Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries.
Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector.
Transduction of a fiber-mutant adenovirus for the HSVtk gene highly augments the cytopathic effect towards gliomas.
Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
Transduction of the herpes thymidine kinase gene into premalignant murine mammary epithelial cells renders subsequent breast cancers responsive to ganciclovir therapy.
Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy.
Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.
Transgenic mouse models for gonadal tumorigenesis.
Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial.
Treatment of medullary thyroid carcinoma by combined expression of suicide and interleukin-2 genes.
Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration.
Treatment of rat experimental brain tumors by herpes simplex virus thymidine kinase gene-transduced allogeneic tumor cells and ganciclovir.
Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery.
Tumor 3'-Deoxy-3'-18F-Fluorothymidine (18F-FLT) Uptake by PET Correlates with Thymidine Kinase 1 Expression: Static and Kinetic Analysis of 18F-FLT PET Studies in Lung Tumors.
Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.
Tumor cells escape suicide gene therapy by genetic and epigenetic instability.
Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair.
Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.
Tumor markers in pleural effusions.
Tumor markers in staging and prognosis of colorectal carcinoma.
Tumor markers in the diagnosis and follow-up of head and neck cancer: role of CEA, CA 19-9, SCC, TK, and dTTPase.
Tumor markers. Consensus Conference on Diagnosis and Prognostic Parameters in Localized Prostate Cancer. Stockholm, Sweden, May 12-13, 1993.
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
Tumor Restrictive Suicide Gene Therapy for Glioma Controlled by the FOS Promoter.
Tumor Tropism of Intravenously Injected Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells and Their Gene Therapy Application in a Metastatic Breast Cancer Model.
Tumor Vascular Targeted Delivery of Polymer-conjugated Adenovirus Vector for Cancer Gene Therapy.
Tumor-associated thymidine kinase in the sera of rats with transplanted hepatomas.
Tumor-selective gene transduction and cell killing with an oncotropic autonomous parvovirus-based vector.
Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promoter.
Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PET.
Tumor-specific promoter-driven adenoviral therapy for insulinoma.
Tumor-targeted Salmonella as a novel anticancer vector.
Tumor-Targeted Salmonella: Strain Development and Expression of the HSV-tK Effector Gene.
Tumour markers as prognostic aids in prostatic carcinoma.
Two forms of thymidine kinase in normal and tumor tissues of animals.
Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase.
Unavailability of thymidine kinase does not preclude the use of German comprehensive prognostic index: results of an external validation analysis in early chronic lymphocytic leukemia and comparison with MD Anderson Cancer Center model.
Uncoupling of 2-fluoro-2-deoxyglucose transport and phosphorylation in rat hepatoma during gene therapy with HSV thymidine kinase.
Unrepairable DNA double-strand breaks initiate cytotoxicity with HSV-TK/ganciclovir.
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer.
Uridine kinase, adenylate kinase, and guanase in human lung tumors.
Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer.
Use of protamine to augment adenovirus-mediated cancer gene therapy.
Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system.
Use of the mouse mammary tumor virus long terminal repeat to promote steroid-inducible expression of v-mos.
Use of tumor-targeting trans-splicing ribozyme for cancer treatment.
Use of von Willebrand factor promoter to transduce suicidal gene to human endothelial cells, HUVEC.
Using fluorodeoxythymidine to monitor anti-EGFR inhibitor therapy in squamous cell carcinoma xenografts.
Using [¹?F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model.
Vaccinia as a vector for gene delivery.
Vaccinia Virus Shuffling: deVV5, a Novel Chimeric Poxvirus with Improved Oncolytic Potency.
Valproic acid enhances anti-tumor effect of mesenchymal stem cell mediated HSV-TK gene therapy in intracranial glioma.
Variable responsiveness of hormone-inducible hybrid genes in different cell lines.
Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.
Vascular damage and anti-angiogenic effects of tumor vessel-targeted adenovirus-mediated herpes simplex virus thymidine kinase gene.
Viral mediated gene therapy for the management of metastatic thyroid carcinoma.
Virotherapy of the Malignant U87 Human Glioblastoma in the Orthotopic Xenotransplantation Mouse SCID Model.
Virus-associated tumor imaging by induction of viral gene expression.
Virus-free transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment induces tumor cell death.
Viruses in the treatment of brain tumors.
Visualization of gene therapy with a liver cancer-targeted adeno-associated virus 3 vector.
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins.
VP22 does not significantly enhance enzyme prodrug cancer gene therapy as a part of a VP22-HSVTk-GFP triple fusion construct.
VP22 enhanced intercellular trafficking of HSV thymidine kinase reduced the level of ganciclovir needed to cause suicide cell death.
VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment.
[18F]-FLT Positron Emission Tomography can be used to image the response of sensitive tumors to PI3-Kinase inhibition with the novel agent GDC-0941.
[A study of thymidine kinase activity in lung cancer tissue]
[Activities of enzymes converting 5-fluorouracil to 5-fluorouridine-5' monophosphate and 5-fluorodeoxyuridine-5' monophosphate in subcultured cell lines and solid tumor tissues]
[Adenovirus-mediated herpes simplex virus thymidine kinase gene transference and combined drug therapy leads to apoptosis of human epithelial ovarian cancer cells]
[Age-dependent characteristics of metabolism of DNA precursors in healthy women, patients with mastopathy and breast cancer]
[An uncommon form of thymidine kinase in breast cancers]
[Antitumor gene therapy using suicide genes]
[Application of serum thymidine kinase 1 of 26 055 cases in health screening for early detection of premalignant/early malignant tumors].
[Autoradiography reporter gene (Ad5-tk carrying HSV1-tk gene) expression imaging in rat myocardium]
[Changes in the replication apparatus and phosphorus-containing metabolite pool in experimental tumors in animals during development]
[Clinical value of thymidine kinase activities in sera and tumor tissues of patients with colorectal cancer]
[Close relation between fetal thymidine kinase and thymidylate kinase activities in breast cancer]
[Delivery of "suicide" thymidine kinase gene of herpes virus in the complex with cationic peptide into human hepatoma cells in vitro]
[Demonstration of fetal-type thymidine kinase in cancer of the breast]
[Effect of pAdKDR-tk suicide gene system on tumor vascular endothelial cells in nude mice with nasopharyngeal carcinoma]
[Effect of the herpes simplex virus I-thymidine kinase gene-ganciclovir system on the transplant of human ovarian cancer on the omentum of nude mice]
[Effect of total parenteral nutrition on the nutritional status and immunocompetence in host and on the tumor growth]
[Evaluation of the effectiveness of determining thymidine kinase activity in the differential diagnosis of CNS tumors]
[Experimental studies on the characteristics of suicide gene system HSV-tk/GCV and its effect on dendritic cells]
[Gene therapy for cancer]
[Gene therapy for cerebral tumors: use of an adenovirus in the glioma C6 rat model]
[Gene therapy of a model of glioblastoma in rats using adenovirus vector encoding the HSVtk gene]
[Gene therapy of cerebral glioblastoma by adenovirus vector. Experimental model in the rat]
[Gene therapy of primary cancers of the liver: hopes and realities]
[Gene transfer and radiotherapy]
[Generation of a trans-complementable defective recombinant provirus and loading a transgene]
[Hypoxia augments the killing effect of herpes simplex virus thymidine kinase gene expression actuated by the promoter of the vascular endothelial growth factor gene on human hepatocellular tumor cells]
[In vivo study on intrathecal use of 5-fluoro-2'-deoxyuridine (FdUrd) in meningeal dissemination of malignant tumor]
[Inhibitory effect of ganciclovir on the HSV1-tk positive subcutaneous tumors transplanted with human ovarian cancer in nude mice]
[Killing effect of adenovirus vector-mediated herpes simplex virus thymidine kinase gene recombinant construct on various cancer cells]
[Molecular imaging for PET-CT reporter gene in breast adenocarcinoma (HSV1-tk) of subcutaneous xenografts in living nude mice]
[Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others]
[Oncolytic poxviruses].
[Prognostic implications of biologic markers in intracranial meningiomas: 120 cases]
[Prognostic value of fetal thymidine kinase measurements in breast cancer]
[Prognostic value of thymidine kinase in cancer of the breast]
[Progress of EBNA1/oriP-based plasmid applied in gene therapy]
[Prospect of gene therapy for metastatic foci of gastric cancer]
[Recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene transfer followed by ganiciclovir administration effectively inhibits growth of human small-cell lung cancer in a murine xenotransplant model]
[Research Progress on Prognostic Factors of Multiple Myeloma--Review].
[Serum thymidine kinase activity of various cancer and HBV positive liver diseases]
[Studies on evaluation of natural products for antiviral effects and their applications]
[Studies on the mechanism of cytotoxicity of 5-fluorouracil--through impairment of metabolism]
[Studies on the thymidine-triphosphate synthesis in malignant tumors. I. Effects of thymidine on deoxyribonucleoside triphosphate pools and deoxyribonucleic acid synthesis (author's trans)]
[Studies on the thymidine-triphosphate synthesis in malignant tumors. II. Effect of hyperthermia, Vitamin K and Cytotoxic agents (author's transl)]
[Study of DNA microarray chip of associated genes of hydatidiform mole]
[Synthesis of GnRH analogs and their application in targeted gene delivery systems].
[Targeted killing effect of mucin-1 single chain antibody targeting, lentivirus-mediated suicide gene therapy and ganciclovir in mucin-1+ ovarian epithelial carcinoma cells]
[The effect of vinblastine on DNA metabolism in turnover cells (author's transl)]
[The enzymatic activity of DNA metabolism of the blood in patients operated on in stomach cancer]
[Therapeutic effect of ovarian intra-arterial infusion of GE7-delivery system-mediated HSVl-tk/ganciclovir gene therapy in a rat model of malignant ovarian tumor].
[Thymidine kinase activity in mammary tumors of animals exposed to estradiol as an index of tumor hormone dependence]
[Thymidine kinase activity, intracellular TTP content and DNA synthesis in transplantable hepatomas and lymphoid tissue of the host]
[Thymidine kinase as a biological marker in neoplasms of the lung and mediastinum]
[Thymidine kinase isozyme in cancer of the colon--correlation to pathology and prognosis]
[Thymidine kinase isozyme in DMH-induced colon tumor in rats]
[Transfer of the thymidine kinase gene in treating mouse TK- cells with DNA preparations from human tumor cells]
[Treatment of experimental liver tumors by in vivo suicide gene transfer in rats]
[Using the thymidine kinase gene in therapy of solid tumors]
[Value of thymidine kinase in the prediction of response to treatment by chemotherapy or hormone therapy in breast cancer]
Neoplastic Cells, Circulating
Circulating Biomarkers of CDK4/6 Inhibitors Response in Hormone Receptor Positive and HER2 Negative Breast Cancer.
Effect of NK cell immunotherapy on immune function in patients with hepatic carcinoma: A preliminary clinical study.
Neuralgia, Postherpetic
Testing the sensitivities of noncognate inhibitors to varicella zoster virus thymidine kinase: implications for postherpetic neuralgia therapy with existing agents.
Neuroblastoma
Altered thymidine kinase or thymidylate synthetase activities in 5-fluoro deoxyuridine resistant variants of mouse neuroblastoma.
Bystander-mediated regression of murine neuroblastoma via retroviral transfer of the HSV-TK gene.
Characterization of tissue-specific transcription by the human synapsin I gene promoter.
Correlations of dihydropyrimidine dehydrogenase, thymidine phosphorylase and thymidine kinase activities in strongly and weakly malignant cultured murine neuroblastoma cells.
Differential expression of MARCKS and other calmodulin-binding protein kinase C substrates in cultured neuroblastoma and glioma cells.
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
Effects of retroviral-mediated herpes simplex virus thymidine kinase gene transfer to murine neuroblastoma cell lines in vitro and in vivo.
Experimental study of thymidine kinase gene therapy of neuroblastoma in vitro and in vivo.
In vivo modelling of chemo-resistant neuroblastoma provides new insights into chemo-refractory disease and metastasis.
NT-polyplex: a new tool for therapeutic gene delivery to neuroblastoma tumors.
Neuroectodermal Tumors, Primitive
INSM1 Promoter-Driven Adenoviral Herpes Simplex Virus Thymidine Kinase Cancer Gene Therapy for the Treatment of Primitive Neuroectodermal Tumors.
Neuroendocrine Tumors
Modifications to the INSM1 promoter to preserve specificity and activity for use in adenoviral gene therapy of neuroendocrine carcinomas.
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Neurofibroma
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours - A prognostic test after surgical resection.
Neurofibrosarcoma
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours - A prognostic test after surgical resection.
Neurologic Manifestations
Increased risk of neurological relapse in acute lymphoblastic leukemias with high levels of cerebrospinal fluid thymidine kinase at diagnosis.
Newcastle Disease
Simultaneous Deletion of Virulence Factors and Insertion of Antigens into the Infectious Laryngotracheitis Virus Using NHEJ-CRISPR/Cas9 and Cre-Lox System for Construction of a Stable Vaccine Vector.
Vaccination of chickens with a recombinant fowlpox virus containing the hemagglutinin-neuraminidase gene of Newcastle disease virus under the control of the fowlpox virus thymidine kinase promoter.
Obesity
Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats.
Ophthalmoplegia, Chronic Progressive External
Alteration of nucleotide metabolism: a new mechanism for mitochondrial disorders.
Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions.
Opportunistic Infections
3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.
Optic Atrophy, Hereditary, Leber
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
Optic Nerve Diseases
Beyond cervical lipomas: myoclonus, gait disorder and multisystem involvement leading to mitochondrial disease.
Orthomyxoviridae Infections
Responses of cattle, sheep and poultry to a recombinant vaccinia virus expressing a swine influenza haemagglutinin.
Osteosarcoma
A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine.
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.
Antiadenovirus activities of several classes of nucleoside and nucleotide analogues.
Bystander-mediated regression of osteosarcoma via retroviral transfer of the herpes simplex virus thymidine kinase and human interleukin-2 genes.
Chemogene therapy: osteocalcin promoter-based suicide gene therapy in combination with methotrexate in a murine osteosarcoma model.
D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase.
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.
Highly potent transcriptional activation by 16-ene derivatives of 1,25-dihydroxyvitamin D3. Lack of modulation by 9-cis-retinoic acid of response to 1,25-dihydroxyvitamin D3 or its derivatives.
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Osteosarcoma and chondrosarcoma as targets for virus vectors and herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Overexpression of c-fos increases recombination frequency in human osteosarcoma cells.
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.
Selective killing of osteosarcoma cells in culture after retroviral mediated gene transfer of a herpes simplex thymidine kinase suicide gene.
Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine.
Synthesis of conformationally North-locked pyrimidine nucleosides built on an oxabicyclo[3.1.0]hexane scaffold.
Treatment of experimental osteosarcoma tumors in rat by herpes simplex thymidine kinase gene transfer and ganciclovir.
Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.
[Experimental research in vitro of TK/GCV system for osteosarcoma MG-63 cell damage].
[Suppression of osteosarcoma in vitro by coexpression of antisense VEGF165 cDNA and thymidine kinase gene]
Ovarian Neoplasms
Adenovirus mediated thymidine kinase gene therapy may enhance sensitivity of ovarian cancer cells to chemotherapeutic agents.
Adenovirus-mediated gene therapy of ovarian cancer in a mouse model.
Adenovirus-mediated thymidine kinase gene therapy and coxsackie adenovirus receptor expression in ovarian cancer cells.
Adenovirus-mediated thymidine kinase gene therapy for recurrent ovarian cancer: expression of coxsackie-adenovirus receptor and integrins alphavbeta3 and alphavbeta5.
Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up.
Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer.
Co-transduction of herpes simplex virus thymidine kinase gene and human interleukin-2 gene into mouse ovarian cancer cell line, OVHM.
Comparison of long-term survival of cytomegalovirus promotre versus Rous Sarcoma virus promoter-driven thymidine kinase gene therapy in nude mice bearing human ovarian cancer.
Delivery of herpes simplex thymidine kinase bystander effect by engineered human mesothelial cells for the treatment of ovarian cancer.
High-efficacy thymidine kinase gene transfer to ovarian cancer cell lines mediated by herpes simplex virus type 1 vector.
Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer.
Improvement of gene therapy for ovarian cancer by using acyclovir instead of ganciclovir in adenovirus mediated thymidine kinase gene therapy.
In vivo gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration.
Intraperitoneal adenovirus-mediated suicide gene therapy in combination with either topotecan or paclitaxel in nude mice with human ovarian cancer.
Ovarian cancer gene therapy: repeated treatment with thymidine kinase in an adenovirus vector and ganciclovir improves survival in a novel immunocompetent murine model.
Ovarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element.
Papers to appear in forthcoming issues
Persistent adenovirus-mediated thymidine kinase gene expression in ovarian cancer cells increases cell killing efficacy over time.
Procaspase-3 enhances the in vitro effect of cytosine deaminase-thymidine kinase disuicide gene therapy on human ovarian cancer.
Research on application value of combined detection of serum CA125, HE4 and TK1 in the diagnosis of ovarian cancer.
Serum thymidine kinase levels are elevated and exhibit diurnal variations in patients with advanced ovarian cancer.
Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications.
Suicide gene therapy of ovarian cancer: an experimental study in rats using retroviral-mediated transfer of herpes simplex virus thymidine kinase gene.
The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT.
The piggyback transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT.
Thymidine kinase (TK) gene therapy of solid tumors: valacyclovir facilitates outpatient treatment.
Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer.
[Animal experiment on gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration in vivo]
[Effect of the herpes simplex virus I-thymidine kinase gene-ganciclovir system on the transplant of human ovarian cancer on the omentum of nude mice]
[Effects of herpes simplex virus thymidine kinase gene transduction and prodrug on ovarian cancer cell]
[In vitro experimental study of gene therapy for ovarian cancer with thymidine kinase gene of herpes simplex virus mediated by a non-viral GE7 delivery system]
[Inhibitory effect of ganciclovir on the HSV1-tk positive subcutaneous tumors transplanted with human ovarian cancer in nude mice]
[Transfer of thymidine kinase gene of herpes simplex virus mediated by retrovirus vector into ovarian cancer cells]
Pancreatic Neoplasms
Effective ablation of pancreatic cancer cells in SCID mice using systemic adenoviral RIP-TK/GCV gene therapy.
Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene.
Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer.
Evaluation of pyrimidine metabolising enzymes and in vitro uptake of 3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]FLT) in pancreatic cancer cell lines.
Gene therapy for peritoneal dissemination of pancreatic cancer by liposome-mediated transfer of herpes simplex virus thymidine kinase gene.
Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir.
Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer.
In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model.
Positive selection of gene-modified cells increases the efficacy of pancreatic cancer suicide gene therapy.
Preoperative Serum Thymidine Kinase Activity as Novel Monitoring, Prognostic, and Predictive Biomarker in Pancreatic Cancer.
Retrovirus-mediated herpes simplex virus thymidine kinase gene transfer in pancreatic cancer cell lines: an incomplete antitumor effect.
Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells results in variable efficiency on the bystander killing: implications for gene therapy.
Targeting of suicide gene delivery in pancreatic cancer cells via FGF receptors.
Thymidine kinase 1 silencing retards proliferative activity of pancreatic cancer cell via E2F1-TK1-P21 axis.
[Expression of the radio-inducible TK suicide gene controlled by Egr-1 promoter in pancreatic cancer cells: an in vitro experiment]
[Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others]
Papilloma
An expression vector inhibits gene expression in Xenopus embryos by antisense RNA.
Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle.
Recovery of a hybrid vector, derived from bovine papilloma virus DNA, pBR322 and the HSV tk gene, by bacterial transformation with extrachromosomal DNA from transfected rodent cells.
Paramyxoviridae Infections
Expression of the F and HN glycoproteins of human parainfluenza virus type 3 by recombinant vaccinia viruses: contributions of the individual proteins to host immunity.
Paraproteinemias
Analysis of thymidine kinase serum levels by novel method DiviTum™ in multiple myeloma and monoclonal gammopathy of undetermined significance - comparison with imaging methods 99mTc-MIBI scintigraphy and 18F-FDG PET/CT.
Plasma cell proliferation in monoclonal gammopathies: measurement using BU-1 antibody in flow cytometry and microscopy: comparison with serum thymidine kinase.
Prognostic significance of serum immunoglobulin paraprotein in patients with chronic lymphocytic leukemia.
Serum thymidine kinase and beta-2 microglobulin in monoclonal gammopathies.
Serum thymidine kinase in monoclonal gammopathies. A prospective study. The Cooperative Group for Study and Treatment of Multiple Myeloma.
[Analysis of serum levels of selected biological parameters in monoclonal gammopathy of undetermined significance and multiple myeloma]
Parasitic Diseases
Alpha-Herpesvirus Thymidine Kinase Genes Mediate Viral Virulence and Are Potential Therapeutic Targets.
Parathyroid Neoplasms
Purification and characterization of calcium-calmodulin kinase II from human parathyroid glands.
Peritoneal Neoplasms
Combined suicide and cytokine gene therapy for peritoneal carcinomatosis.
HSV-1 thymidine kinase gene therapy for colorectal adenocarcinoma-derived peritoneal carcinomatosis.
HSV-1 thymidine kinase gene therapy for peritoneal carcinomatosis.
Similar efficiency of DNA-liposome complexes and retrovirus-producing cells for HSV-tk suicide gene therapy of peritoneal carcinomatosis.
Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses.
Peritonitis
Retrovirus-mediated in vivo gene therapy using the herpes simplex virus thymidine kinase gene against carcinomatous peritonitis.
Pheochromocytoma
Localization of cis-acting sequences in the latency-related promoter of bovine herpesvirus 1 which are regulated by neuronal cell type factors and immediate-early genes.
Photosensitivity Disorders
Photofrin II photosensitization is mutagenic at the tk locus in mouse L5178Y cells.
Pituitary Neoplasms
Combination of multiple mRNA markers (PTTG1, Survivin, UbcH10 and TK1) in the diagnosis of Taiwanese patients with breast cancer by membrane array.
Epstein-Barr virus-based vector improves the tumor cell killing effect of pituitary tumor in HVJ-liposome-mediated transcriptional targeting suicide gene therapy.
GENE THERAPY FOR THE TREATMENT OF PITUITARY TUMORS.
Gene therapy in the neuroendocrine system: its implementation in experimental models using viral vectors.
Neuroendocrinology of aging: the potential of gene therapy as an interventive strategy.
Okadaic acid, a protein phosphatase inhibitor, enhances transcription of a receptor gene containing sequence A of the human prolactin promoter.
Potential of gene therapy for the treatment of pituitary tumors.
Regulatory elements of the human proopiomelanocortin gene promoter.
Plague
A Thymidine Kinase recombinant protein-based ELISA for detecting antibodies to Duck Plague Virus.
Pleural Effusion
Thymidine kinase 1 concentration in pleural effusion is a diagnostic marker and survival predictor for malignant pleural effusion.
Tumor markers in pleural effusions.
Pleural Effusion, Malignant
Thymidine kinase 1 concentration in pleural effusion is a diagnostic marker and survival predictor for malignant pleural effusion.
Pneumoperitoneum
Effects of CO2 pneumoperitoneum on the expression of thymidine kinase 1 and Ki67 in colorectal carcinoma cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical significance of thymidine kinase in Egyptian children with acute lymphoblastic leukemia.
Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation.
Increased risk of neurological relapse in acute lymphoblastic leukemias with high levels of cerebrospinal fluid thymidine kinase at diagnosis.
Lymphocyte thymidine kinase and treatment response in acute lymphocytic leukemia.
Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker.
The role of p16 in the E2F-dependent thymidine kinase regulation.
Prolactinoma
Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas.
Potential of gene therapy for the treatment of pituitary tumors.
Prostatic Hyperplasia
In vivo characterization of a prostate-specific antigen promoter-based suicide gene therapy for the treatment of benign prostatic hyperplasia.
Serum thymidine kinase 1 is associated with Gleason score of patients with prostate carcinoma.
Prostatic Neoplasms
20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines.
A Pilot Study of Quality of Life of Patients with Hormone-refractory Prostate Cancer after Gene Therapy.
Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer.
Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity.
Altered expression of connexin-43 and impaired capacity of gap junctional intercellular communication in prostate cancer cells.
Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker.
CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomography.
Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth.
Comparison of bioactivities of 5-Fluoro, 5-Iodo, 5-Iodovinyl, and 5-fluorovinyl arabinosyl uridines against SR-39 TK-transfected murine prostate cancer cells.
Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer.
Cooperative therapeutic effects of herpes simplex virus thymidine kinase gene/ganciclovir system and chemotherapeutic agents on prostate cancer in vitro.
Cotargeting tumor and stroma in a novel chimeric tumor model involving the growth of both human prostate cancer and bone stromal cells.
Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase.
Gene therapy for castration-resistant prostate cancer cells using JC polyomavirus-like particles packaged with a PSA promoter driven-suicide gene.
Gene therapy for prostate cancer: toxicological profile of four HSV-tk transducing adenoviral vectors regulated by different promoters.
Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques.
Identification of glucocorticoid-responsive elements that control transcription of rat glutamine synthetase.
Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice.
Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer.
Low p16(INK4a) Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone.
Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.
Micro-PET/CT monitoring of herpes thymidine kinase suicide gene therapy in a prostate cancer xenograft: the advantage of a cell-specific transcriptional targeting approach.
Optimizing prostate cancer suicide gene therapy using herpes simplex virus thymidine kinase active site variants.
Osteonectin Promoter-Mediated Suicide Gene Therapy of Prostate Cancer.
Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer.
Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer.
Phase I/II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer--a preliminary report.
Progress report on phase I/II clinical trial of Ad-OC-TK plus VAL therapy for metastatic or locally recurrent prostate cancer: Initial experience at Kobe University.
Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models.
Protein Delivery of Thymidylate Kinase Mediated by Tumor-Specific Antibody-Precoated Microvesicles.
Suicide gene therapy for prostate cancer using a replication-deficient adenovirus containing the herpesvirus thymidine kinase gene.
Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer.
Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy.
Suppression of bone metastatic castration-resistant prostate cancer cell growth by a suicide gene delivered by JC polyomavirus-like particles.
Targeted expression of E. coli purine nucleoside phosphorylase and Fludara for prostate cancer therapy.
Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model.
Thymidine Kinase Gene Modified Bone Marrow Mesenchymal Stem Cells as Vehicles for Anti-tumor Therapy.
Thymidine Kinase-1 as Additional Diagnostic Marker of Prostate Cancer.
Treatment efficiency of a suicide gene therapy using prostate-specific membrane antigen promoter/enhancer in a castrated mouse model of prostate cancer.
Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters.
Pseudolymphoma
Pyrimidine and purine activities in non-Hodgkin's lymphoma. Correlation with histological status and survival.
Pseudorabies
A comparative study of pseudorabies virus (PRV) strains with defects in thymidine kinase and glycoprotein genes.
A study of two mutant strains of pseudorabies virus (PRV) unable to express thymidine kinase (TK) function.
A vaccine strain of pseudorabies virus with deletions in the thymidine kinase and glycoprotein X genes.
Attenuated properties of thymidine kinase-negative deletion mutant of pseudorabies virus.
Characterization of Japanese isolates of Aujeszky's disease virus by restriction endonuclease cleavage patterns, virulence in mice and thymidine kinase activity.
Characterization of promoters integrated in the genome of bovine herpesvirus-1 (BHV-1).
Characterization of virulent and attenuated strains of pseudorabies virus for thymidine kinase activity, virulence and restriction patterns.
Construction of bovine herpesvirus-1 (BHV-1) recombinants which express pseudorabies virus (PRV) glycoproteins gB, gC, gD, and gE.
Diagnostic compatibility of a thymidine kinase, inverted repeat, gI, and gpX modified live gene-deleted PRV vaccine with three differential ELISAs.
Efficacy of a pseudorabies virus vaccine based on deletion mutant strain 783 that does not express thymidine kinase and glycoprotein I.
Evaluation of swinepox virus as a vaccine vector in pigs using an Aujeszky's disease (pseudorabies) virus gene insert coding for glycoproteins gp50 and gp63.
Evaluation of the safety and efficacy of a thymidine kinase, inverted repeat, gI, and gpX gene-deleted pseudorabies vaccine.
Experimental infection of pigs with a thymidine kinase negative strain of pseudorabies virus.
Genetic basis of the neurovirulence of pseudorabies virus.
Genetic recombination of pseudorabies virus: evidence that homologous recombination between insert sequences is less frequent than between autologous sequences.
Genotypic screening of pseudorabies virus strains for thymidine kinase deletions by use of the polymerase chain reaction.
Growth properties and vaccine efficacy of recombinant pseudorabies virus defective in glycoprotein E and thymidine kinase genes.
In vivo recombination of pseudorabies virus strains in mice.
Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the induction of protective immunity.
Inactivation of the thymidine kinase gene of a gI deletion mutant of pseudorabies virus generates a safe but still highly immunogenic vaccine strain.
Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus types 1 and 2 and pseudorabies virus.
Influence of vaccination route on the efficacy of Aujeszky's disease deletion-mutant vaccine.
Is recombination of PRV vaccine strains a real problem?
Lack of stereospecificity of suid pseudorabies virus thymidine kinase.
Loss of pseudorabies virus thymidine kinase activity due to a single base mutation and amino acid substitution.
Mitochondrial and herpesvirus-specific deoxypyrimidine kinases.
Molecular analysis of pseudorabies viral vaccines and their rapid differentiation from wild-type isolates using DNA-amplified glycoprotein I and thymidine kinase gene segment polymorphisms.
Multiple sets of adjacent mu E1 and oct-1 binding sites upstream of the pseudorabies virus immediate-early gene promoter.
Necrotic oophoritis in gilts associated with experimental inoculation of a viral gene-deletion mutant pseudorabies vaccine.
Novel strategy for generation and titration of recombinant adeno-associated virus vectors.
Replication of virulent and attenuated strains of Aujeszky's disease virus in swine alveolar macrophages.
Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection.
Safety of an Aujeszky's disease vaccine based on deletion mutant strain 783 which does not express thymidine kinase and glycoprotein I.
Second-generation pseudorabies virus vaccine with deletions in thymidine kinase and glycoprotein genes.
Some characteristics of four attenuated vaccine virus strains and a virulent strain of Aujeszky's disease virus.
The response of pigs inoculated with a thymidine kinase-negative (TK-) pseudorabies virus to challenge infection with virulent virus.
The role of pseudorabies virus thymidine kinase expression in trigeminal ganglion infection.
Vaccination of mice and swine with a pseudorabies virus mutant lacking thymidine kinase activity.
Vaccination of swine with thymidine kinase-deficient mutants of pseudorabies virus.
Virus reactivation in pigs latently infected with a thymidine kinase negative vaccine strain of pseudorabies virus.
[Thymidine kinase activity of virulent and vaccinal strains of Aujeszky's disease virus]
Pyelonephritis
Chronic pyelonephritis presenting as multiple tumor-like renal lesions.
Pyometra
Elevation of serum thymidine kinase 1 in a bacterial infection: canine pyometra.
Rabies
Development of a recombinant vaccinia-rabies vaccine for oral vaccination of foxes against rabies.
Raccoon poxvirus live recombinant feline panleukopenia virus VP2 and rabies virus glycoprotein bivalent vaccine.
The development and use of a vaccinia-rabies recombinant oral vaccine for the control of wildlife rabies; a link between Jenner and Pasteur.
Renal Insufficiency
Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance.
Respiratory Insufficiency
Preferent Diaphragmatic Involvement in TK2 Deficiency: An Autopsy Case Study.
Successful pregnancy and cesarean delivery via noninvasive ventilation in mitochondrial myopathy.
Respiratory Tract Infections
In vivo function of the Murid Herpesvirus-4 ribonucleotide reductase small subunit.
Retinal Necrosis Syndrome, Acute
Expression of the Varicella Zoster Virus Thymidine Kinase and Cytokines in Patients with Acute Retinal Necrosis Syndrome.
[Expression of the varicella zoster virus thymidine kinase and cytokines in patients with acute retinal necrosis syndrome]
Retinoblastoma
A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene.
Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma.
Adventitial gene transfer to arterial wall.
An experimental application of gene therapy for human retinoblastoma.
Cardiovascular gene therapy.
Expression of the cyclin-dependent kinase inhibitor p16 during the ongoing cell cycle.
Failure of RB1 to reverse the malignant phenotype of human tumor cell lines.
Gene and other biological therapies for vascular diseases.
Gene therapy for ischemic heart disease.
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.
p600, a unique protein required for membrane morphogenesis and cell survival.
Pharmacokinetics, safety, activity, and biomarker analysis of palbociclib plus letrozole as first-line treatment for ER+/HER2- advanced breast cancer in Chinese women.
Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir.
Suicide gene therapy for treatment of retinoblastoma in a murine model.
The role of p16 in the E2F-dependent thymidine kinase regulation.
Vascular gene transfer for the treatment of restenosis and atherosclerosis.
Vascular gene transfer.
[Studies on thymidine kinase gene (TK) and GCV system for treatment of human retinoblastoma (RB)]
[The status of gene therapy in cardiovascular medicine]
Retroviridae Infections
Suicide Gene Therapy Mediated with Exosomes Produced by Mesenchymal Stem/Stromal Cells Stably Transduced with HSV Thymidine Kinase.
Rhabdomyolysis
Recurrent rhabdomyolysis and exercise intolerance: A new phenotype of late-onset thymidine kinase 2 deficiency.
Rhabdomyosarcoma
Suicide gene therapy of rhabdomyosarcoma.
Rift Valley Fever
Protection of Cattle Elicited Using a Bivalent Lumpy Skin Disease Virus-Vectored Recombinant Rift Valley Fever Vaccine.
Rinderpest
Immunization with a vaccinia recombinant expressing the F protein protects rabbits from challenge with a lethal dose of rinderpest virus.
Recombinant capripoxvirus expressing the hemagglutinin protein gene of rinderpest virus: protection of cattle against rinderpest and lumpy skin disease viruses.
Salivary Gland Neoplasms
Combination gene therapy for salivary gland cancer.
Sarcoidosis
Increased serum thymidine kinase activity in acute sarcoidosis.
Sarcoma
3'-deoxy-3'-[(18) F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: A pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response.
Adenoviral thymidine kinase prodrug gene therapy inhibits sarcoma growth in vivo.
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences.
Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1.
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors.
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
Efficient expression of cloned complementary DNAs for secretory proteins after injection into Xenopus oocytes.
Enhanced transformation by a simian virus 40 recombinant virus containing a Harvey murine sarcoma virus long terminal repeat.
Gene therapy for endometrial carcinoma with the herpes simplex thymidine kinase gene.
In vivo imaging of cell proliferation in meningioma using 3'-deoxy-3'-[18F]fluorothymidine PET/MRI.
Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice.
Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer.
Multiple transduction as a means of preserving ganciclovir chemosensitivity in sarcoma cells carrying retrovirally transduced herpes thymidine kinase genes.
Sarcoma 180
Mode of action of the bioreductive alkylating agent, 2,3-bis(chloromethyl)-1,4-naphthoquinone.
Mouse ascites sarcoma 180 thymidylate kinase. General properties, kinetic analysis, and inhibition studies.
Sarcoma, Avian
A comparison of transcriptional regulatory element activities in transformed and non-transformed rat anterior pituitary cells.
Activation of an endogenous retrovirus enhancer by insertion into a heterologous context.
Adenovirus-mediated gene therapy of experimental gliomas.
Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1.
Allium sativum potentiates suicide gene therapy for murine transitional cell carcinoma.
Antiviral activity of herpes simplex virus vectors expressing murine alpha 1-interferon.
Avian sarcoma virus transformed hamster cells resistant to bromodeoxyuridine and deficient in thymidine kinase activity.
Characterization of the promoter of human pulmonary surfactant protein B gene.
Comparison of long-term survival of cytomegalovirus promotre versus Rous Sarcoma virus promoter-driven thymidine kinase gene therapy in nude mice bearing human ovarian cancer.
Construction of a recombinant adeno-associated virus (rAAV) vector expressing murine interleukin-12 (IL-12).
Demethylation and expression of methylated plasmid DNA stably transfected into HeLa cells.
Differential transient and long-term expression of DNA sequences introduced into T-lymphocyte lines.
Efficiency of introns from various origins in fish cells.
Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo.
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase.
Inhibition of transient gene expression with plasmids encoding herpes simplex virus type 1 UL55 and alpha genes.
Inhibition of viral and cellular promoters by human wild-type p53.
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules.
Persistent adenovirus-mediated thymidine kinase gene expression in ovarian cancer cells increases cell killing efficacy over time.
Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.
Proximal upstream flanking sequences direct calcium regulation of the rat prolactin gene.
Rearrangements of microinjected recombinant DNA in the genome of transgenic mice.
Structure and inducible regulation of the human c-erb B2/neu promoter.
TEF-1 transrepression in BeWo cells is mediated through interactions with the TATA-binding protein, TBP.
The effects of transcriptional regulatory sequences introduced into a retroviral genome.
The human chorionic somatomammotropin gene enhancer is composed of multiple DNA elements that are homologous to several SV40 enhansons.
The location of v-src in a retrovirus vector determines whether the virus is toxic or transforming.
[Animal experiment on gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration in vivo]
Sarcoma, Ewing
Effective suicide gene therapy in vivo by EBV-based plasmid vector coupled with polyamidoamine dendrimer.
Sarcoma, Yoshida
DNA synthesis in tumor-bearing rats.
DNA synthesis in tumor-bearing rats: purification of liver thymidine kinase stimulating factor from Yoshida sarcoma.
Effect of RN-ase treatment on Yoshida sarcoma thymidine kinase.
Intracellular distribution of various enzymes concerned with DNA synthesis from normal and regenerating rat liver, and Yoshida sarcoma.
Metabolism of 5-fluorouracil in sensitive and resistant tumor cells.
Severe Combined Immunodeficiency
Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice.
Small Cell Lung Carcinoma
Clinical and serologic markers of stage and prognosis in small cell lung cancer. A multivariate analysis.
Correlation between serum tumor marker levels and tumor proliferation in small cell lung cancer.
Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.
Neuron-specific enolase and thymidine kinase as an aid to the diagnosis and treatment monitoring of small cell lung cancer.
Prognostic value of serum thymidine kinase, tissue polypeptide antigen and neuron specific enolase in patients with small cell lung cancer.
Serum thymidine kinase 1 levels correlates with FDG uptake and prognosis in patients with non small cell lung cancer.
Serum thymidine kinase as a tumor marker of colorectal carcinogenesis induced with 1,2-dimethylhydrazine in rats.
Smallpox
Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox - Part II.
Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox.
Enhancing the Protective Immune Response to Administration of a LIVP-GFP Live Attenuated Vaccinia Virus to Mice.
First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells.
Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus.
Nucleotide sequence of the thymidine kinase gene region of monkeypox and variola viruses.
Preventing the return of smallpox: molecular modeling studies on thymidylate kinase from Variola virus.
Quaternary structure of vaccinia virus thymidine kinase.
Spinal Cord Injuries
Impact of Depletion of Microglia/Macrophages on Regeneration after Spinal Cord Injury.
Squamous Cell Carcinoma of Head and Neck
Cell death of human oral squamous cell carcinoma cell line induced by herpes simplex virus thymidine kinase gene and ganciclovir.
Synthetic radiation-inducible promoters mediated HSV-TK/GCV gene therapy in the treatment of oral squamous cell carcinoma.
Thymidine kinase activity in oral squamous cell carcinoma.
Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma.
[Combined interleukin-2 and herpes simplex virus thymidine kinase gene therapy for head and neck squamous cell carcinoma]
Starvation
Activity of thymidine kinase during the cell cycle in Tetrahymena pyriformis.
EGF-like peptide-enhanced cell movement in Dictyostelium is mediated by protein kinases and the activity of several cytoskeletal proteins.
Ileal hyperplastic response to starvation in the rat.
Regulation of gastric mucosal DNA synthesis during fasting and refeeding in rats.
Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.
Thymidine kinase in mouse liver: variations in soluble and mitochondrial-associated activity that are dependent on age, regeneration, starvation, and treatment with actinomycin D and puromycin.
Stomach Neoplasms
Activities of thymidylate synthetase and thymidine kinase in gastric cancer.
Adenovirus-mediated gene therapy of gastric carcinoma using cancer-specific gene expression in vivo.
Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro.
An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice.
Changes in serum thymidine kinase 1 levels during chemotherapy correlate with objective response in patients with advanced gastric cancer.
Do there exist synergistic antitumor effects by coexpression of herpes simplex virus thymidine kinase with cytokine genes on human gastric cancer cell line SGC7901?
Heat-directed suicide gene therapy mediated by heat shock protein promoter for gastric cancer.
Human colorectal malignancy and oral UFT.
The half-life of thymidine kinase 1 in serum measured by ECL dot blot: a potential marker for monitoring the response to surgery of patients with gastric cancer.
[The dynamics of the enzymatic activity of DNA metabolism during the treatment of stomach cancer patients]
[Thymidine kinase and thymidylate synthetase activities in human gastric cancer]
Stomach Ulcer
[Age-related characteristics of thymidine metabolism in healthy subjects and in patients with stomach ulcer and cancer]
Superinfection
Characterization of Epstein-Barr virus-related thymidine kinase induced in nonproducer cells by superinfection or chemical treatment.
Clonal analysis of early and late stages of erythroleukemia induced by molecular clones of integrated spleen focus-forming virus.
Enhancement of herpes simplex virus type 2 (HSV-2) DNA synthesis in infected cells that constitutively express the BglII-N region of the HSV-2 genome.
Epstein-Barr virus-associated thymidine kinase.
HSV-1 thymidine kinase negative vaccine: pathogenicity, protection, and perils.
Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1.
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters.
Thymidine kinase activity of biochemically transformed mouse cells after superinfection by thymidine kinase-negative, temperature-sensitive, herpes simplex virus mutants.
Thymidine kinase deletion mutants of herpes simplex virus type 1.
Teratocarcinoma
Cotransfer and phenotypic stabilisation of syntenic and asyntenic mink genes into mouse cells by chromosome-mediated gene transfer.
DNA-transformed murine teratocarcinoma cells: regulation of expression of simian virus 40 tumor antigen in stem versus differentiated cells.
Introduction of a viral thymidine kinase gene and the human beta-globin gene into developmentally multipotential mouse teratocarcinoma cells.
Tissue preference and differentiation of malignant rat x mouse hybrid cells in chimaeric mouse fetuses.
Teratoma
A scalable approach to prevent teratoma formation of human embryonic stem cells.
Embryonic Stem Cells Modulate the Cancer-Permissive Microenvironment of Human Uveal Melanoma.
Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy.
Thoracic Neoplasms
Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system.
Thrombocytopenia
Serum Thymidine Kinase 1, Canine-C-Reactive Protein, Haptoglobin, and Vitamin D Concentrations in Dogs with Immune-Mediated Hemolytic Anemia, Thrombocytopenia, and Polyarthropathy.
Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter.
[Mantle cell lymphoma as a diagnostic and therapeutic problem]
thymidine kinase deficiency
Abilities of wild-type and thymidine kinase-deficient Friend mouse erythroleukemia cells to undergo unscheduled DNA synthesis following mutagen treatment.
AMP deaminase and thymidine kinase deficiencies in a mutant mouse S49 cell clone.
Assignment of TK1 encoding thymidine kinase to Syrian hamster chromosome 9 by microcell-mediated chromosome transfer.
Azacytidine induces reversion of thymidine kinase deficiency in Friend erythroleukemia cells.
Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency.
Characterization of encephalitis in adult mice induced by intracerebral inoculation of herpes simplex virus type 1 (KOS) and comparison with mutants showing decreased virulence.
Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances.
Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency.
Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.
Depletion of the other genome-mitochondrial DNA depletion syndromes in humans.
Effects of deoxycytidine and thymidine kinase deficiency on substrate cycles between deoxyribonucleosides and their 5'-phosphates.
Evidence for linear response for the induction of mutations in human cells by x-ray exposures below 10 rads.
Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53.
Genetic neuromuscular disorders: living the era of a therapeutic revolution. Part 2: diseases of motor neuron and skeletal muscle.
Herpes simplex virus resistance to acyclovir: clinical relevance.
Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS.
Induction of thymidine kinase in enzyme-deficient Chinese hamster cells.
Late-onset thymidine kinase 2 deficiency: a review of 18 cases.
Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency.
Mutagen sensitivity in thymidine kinase- and methyltransferase-deficient human lymphoblastoid cells.
Nef from pathogenic simian immunodeficiency virus is a negative factor for vaccinia virus.
Phenotypic evolution of cells resistant to bromodeoxyuridine.
Recurrent rhabdomyolysis and exercise intolerance: A new phenotype of late-onset thymidine kinase 2 deficiency.
Regulatory environment for novel therapeutic development in mitochondrial diseases.
Retrospective natural history of thymidine kinase 2 deficiency.
Successful pregnancy and cesarean delivery via noninvasive ventilation in mitochondrial myopathy.
Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency.
Thymidine kinase 2 and alanyl-tRNA synthetase 2 deficiencies cause lethal mitochondrial cardiomyopathy: case reports and review of the literature.
Transfer of nonselectable genes into mouse teratocarcinoma cells and transcription of the transferred human beta-globin gene.
Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.
Thymoma
Fluctuation of antigen binding activity during the cell cycle in the synchronized population of the murine T hybridoma cell line.
Thyroid Cancer, Papillary
Increased expression of mRNA specific for thymidine kinase, deoxycytidine kinase or thymidine phosphorylase in human papillary thyroid carcinoma.
Thyroid Carcinoma, Anaplastic
Retrovirus-mediated suicide gene/prodrug therapy targeting thyroid carcinoma using a thyroid-specific promoter.
Thyroid Diseases
Expression of genes for certain enzymes of pyrimidine and purine salvage pathway in peripheral blood leukocytes collected from patients with Graves' or Hashimoto's disease.
[Thymidine kinase and its isozyme activities in human thyroid diseases]
Thyroid Neoplasms
A tandemly repeated thyroglobulin core promoter has potential to enhance efficacy for tissue-specific gene therapy for thyroid carcinomas.
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Adenoviral-mediated gene therapy for thyroid carcinoma using thymidine kinase controlled by thyroglobulin promoter demonstrates high specificity and low toxicity.
Adenovirus HSV-TK construct with thyroid-specific promoter: enhancement of activity and specificity with histone deacetylase inhibitors and agents modulating the camp pathway.
An adenoviral vector expressing functional heterogeneous proteins herpes simplex viral thymidine kinase and human interleukin-2 has enhanced in vivo antitumor activity against medullary thyroid carcinoma.
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Construction of gene therapy vectors targeting thyroid cells: enhancement of activity and specificity with histone deacetylase inhibitors and agents modulating the cyclic adenosine 3',5'-monophosphate pathway and demonstration of activity in follicular and anaplastic thyroid carcinoma cells.
Gene therapy of established medullary thyroid carcinoma with herpes simplex viral thymidine kinase in a rat tumor model: relationship of bystander effect and antitumor efficacy.
Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and herpes simplex virus thymidine kinase.
Knockdown of Thymidine Kinase 1 Suppresses Cell Proliferation, Invasion, Migration, and Epithelial-Mesenchymal Transition in Thyroid Carcinoma Cells.
Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.
Retrovirus-mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo.
Retrovirus-mediated suicide gene/prodrug therapy targeting thyroid carcinoma using a thyroid-specific promoter.
Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors.
Viral mediated gene therapy for the management of metastatic thyroid carcinoma.
Tongue Neoplasms
DNA-liposome complexes transduction of herpes simplex virus thymidine kinase renders human tongue cancer cell line sensitive to ganciclovir in vitro.
Tuberculosis
1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase.
2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn).
Activation of NF-kappaB in Mycobacterium tuberculosis- induced interleukin-2 receptor expression in mononuclear phagocytes.
Anti-mycobacterial activity of thymine derivatives bearing boron clusters.
Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals.
Cryophotolysis of caged compounds: a technique for trapping intermediate states in protein crystals.
Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis.
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity.
Immuno-diagnosis of Mycobacterium tuberculosis in sputum, and reduction of timelines for its positive cultures to within 3 h by pathogen-specific thymidylate kinase expression assays.
In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis.
Mycobacterium tuberculosis thymidylate kinase antigen assays for designating incipient, high-risk latent M.tb infection.
Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway.
Protein kinases as antituberculosis targets: The case of thymidylate kinases.
Sero-diagnosis of Active Mycobacterium tuberculosis Disease among HIV Co-infected Persons using Thymidylate Kinase based Antigen and Antibody Capture Enzyme Immuno-Assays.
Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors.
Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.
Structure-aided design of inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors.
Synthesis and antiviral evaluation of ?-l-2'-deoxythreofuranosyl nucleosides.
Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.
Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents.
The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition.
The thymidylate kinase genes from Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus confer 3'-azido-3'-deoxythymidine resistance to Escherichia coli.
Theoretical basis for reducing time-lines to the determination of positive Mycobacterium tuberculosis cultures using thymidylate kinase (TMK) assays.
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes.
[Intratumor injection of recombinant attenuated salmonella carrying Mycobacterium tuberculosis heat shock protein 70 and herpes simplex virus thymidine kinase genes to suppress murine melanoma growth].
Tumor Virus Infections
Identification and nucleotide sequence of the thymidine kinase gene of Shope fibroma virus.
Thymidine kinase activity in human amnion cell cultures infected with Shope fibroma virus.
Urinary Bladder Neoplasms
Adenovirus-mediated suicide gene therapy for bladder cancer: comparison of the cytomegalovirus- and Rous sarcoma virus-promoter.
Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models.
Basis for the differential modulation of the uptake of 5-iododeoxyuridine by 5'-aminothymidine among various cell types.
Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene therapy induces both extrinsic and intrinsic apoptosis in a rat model of bladder cancer.
Combination of adenovirus-mediated thymidine kinase gene therapy with cytotoxic chemotherapy in bladder cancer in vitro.
Cytotoxic activity of gemcitabine in cultured cell lines derived from histologically different types of bladder cancer: Role of thymidine kinase 2.
Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
Massive apoptotic cell death in chemically induced rat urinary bladder carcinomas following in situ HSVtk electrogene transfer.
Modulation of IdUrd-DNA incorporation and radiosensitization in human bladder carcinoma cells.
Modulation of the feedback regulation of thymidine kinase activity by pH in 647V cells.
Muscle-invasive bladder cancer is characterized by overexpression of thymidine kinase 1.
Preferential stimulation of iododeoxyuridine phosphorylation by 5'-aminothymidine in human bladder cancer cells in vitro.
[Studies on herpes simplex virus thymidine kinase gene and GCV system for treatment of human bladder carcinoma]
Uterine Cervical Neoplasms
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
High-level transgene expression mediated by the piggyBac transposon enhances transgenic therapeutic effects in cervical cancer xenografts.
Vaccinia
5-Iodo-2-deoxyuridine resistance of vaccinia viruses in cells endowed with thymidine kinase activity.
A cancer-favoring oncolytic vaccinia virus shows enhanced suppression of stem-cell like colon cancer.
A new oncolytic Vacciniavirus augments antitumor immune responses to prevent tumor recurrence and metastasis after surgery.
A new recombinant vaccinia with targeted deletion of three viral genes: its safety and efficacy as an oncolytic virus.
A PCR-based method for manipulation of the vaccinia virus genome that eliminates the need for cloning.
A recombinant vaccinia virus expressing hepatitis A virus structural polypeptides: characterization and demonstration of protective immunogenicity.
A recombinant vaccinia virus expressing human carcinoembryonic antigen (CEA).
A recombinant vaccinia virus expressing the major capsid protein of Simian rotavirus-induced anti-rotavirus antibodies.
A single amino acid substitution abolishes feedback inhibition of vaccinia virus thymidine kinase.
A vaccinia virus double recombinant expressing the F and H genes of rinderpest virus protects cattle against rinderpest and causes no pock lesions.
Accurate mass precursor ion data and tandem mass spectrometry identify a class I human leukocyte antigen A*0201-presented peptide originating from vaccinia virus.
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.
Addition of the MSA1 signal and anchor sequences to the malaria merozoite surface antigen 1 C-terminal region enhances immunogenicity when expressed by recombinant vaccinia virus.
An oncolytic vaccinia virus armed with anti-human-PD-1 antibody and anti-human-4-1BB antibody double genes for cancer-targeted therapy.
An Oncolytic Vaccinia Virus Armed with GM-CSF and IL-24 Double Genes for Cancer Targeted Therapy.
Analysis of canine herpesvirus gB, gC and gD expressed by a recombinant vaccinia virus.
Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models.
Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers.
Araçatuba virus: a vaccinialike virus associated with infection in humans and cattle.
Association of non-viral proteins with recombinant vaccinia virus virions.
Attenuation of Vaccinia Virus.
Belo Horizonte virus: a vaccinia-like virus lacking the A-type inclusion body gene isolated from infected mice.
Biological characterization of recombinant vaccinia viruses in mice infected by the respiratory route.
Biophysical characterization of vaccinia virus thymidine kinase substrate utilization.
Cell-free synthesis of enzymatically active vaccinia virus thymidine kinase.
Characterization of a binding factor that interacts with the sequences upstream of the vaccinia virus thymidine kinase gene.
Characterization of a vaccinia-like virus isolated in a Brazilian forest.
Characterization of vaccinia virus early promoters and evaluation of their informational content.
Comparison of a conserved region in fowlpox virus and vaccinia virus genomes and the translocation of the fowlpox virus thymidine kinase gene.
Comparison of the virulence of wild-type thymidine kinase (tk)-deficient and tk+ phenotypes of vaccinia virus recombinants after intranasal inoculation of mice.
Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates.
Conserved sequences near the early transcription start sites of vaccinia virus.
Construction and characterization of vaccinia direct ligation vectors.
Construction of a recombinant vaccinia virus expressing the Lassa virus glycoprotein gene and protection of guinea pigs from a lethal Lassa virus infection.
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus.
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus. 1982.
Construction of recombinant swinepox viruses and expression of the classical swine fever virus E2 protein.
Construction of recombinant vaccinia virus expressing GM-CSF and its use as tumor vaccine.
Construction of recombinant vaccinia virus strains using single-stranded DNA insertion vectors.
Construction of recombinant vaccinia virus: cloning into the thymidine kinase locus.
Construction of vaccinia virus recombinants expressing several measles virus proteins and analysis of their efficacy in vaccination of mice.
Control of expression of the vaccinia virus thymidine kinase gene.
Control of thymidine kinase synthesis in IHD vaccinia virus-infected thymidine kinase-deficient LM cells.
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy.
Deletion of fowlpox virus homologues of vaccinia virus genes between the 3 beta-hydroxysteroid dehydrogenase (A44L) and DNA ligase (A50R) genes.
Delineation of the viral products of recombination in vaccinia virus-infected cells.
Determination of the promoter region of an early vaccinia virus gene encoding thymidine kinase.
Development of a recombinant vaccinia-rabies vaccine for oral vaccination of foxes against rabies.
Development of a replication-selective, oncolytic poxvirus for the treatment of human cancers.
Dominant host range selection of vaccinia recombinants by rescue of an essential gene.
Dominant negative selection of vaccinia virus using a thymidine kinase/thymidylate kinase fusion gene and the prodrug azidothymidine.
Effect of in vitro mutations in a vaccinia virus early promoter region monitored by herpes simplex virus thymidine kinase expression in recombinant vaccinia virus.
Effect of interferon on the dynamics of H3-thymidine incorporation and thymidine kinase induction in chick fibroblast cultures infected with vaccinia virus.
Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase.
Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase.
Engineering of double recombinant vaccinia virus with enhanced oncolytic potential for solid tumor virotherapy.
Evaluation of swinepox virus as a vaccine vector in pigs using an Aujeszky's disease (pseudorabies) virus gene insert coding for glycoproteins gp50 and gp63.
Evaluation of the thymidine kinase (tk) locus as an insertion site in the highly attenuated vaccinia MVA strain.
Evaluation of Tumor Specificity and Immunity of Thymidine Kinase-Deleted Vaccinia Virus Guang9 Strain.
Evidence for an "early early" vaccinia virus-induced protein which causes a density change of infected L-M cells.
Evolutionary cancer-favoring engineered vaccinia virus for metastatic hepatocellular carcinoma.
Expression and characterization of the thymidine kinase gene of African swine fever virus.
Expression and regulation of the vaccinia virus thymidine kinase gene in non-permissive cells.
Expression and single-step purification of enzymatically active vaccinia virus thymidine kinase containing an engineered oligohistidine domain by immobilized metal affinity chromatography.
Expression of authentic vaccinia virus-specific and inserted viral and cellular genes under control of an early vaccinia virus promoter is regulated post-transcriptionally in interferon-treated chick embryo fibroblasts.
Expression of avian influenza virus hemagglutinin by recombinant fowlpox virus.
Expression of cloned vaccinia virus DNA sequences introduced into animal cells.
Expression of functional parvoviral NS1 from recombinant vaccinia virus: effects of mutations in the nucleotide-binding motif.
Expression of herpes simplex virus thymidine kinase, mediated by vaccinia virus early promoters.
Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P-450 in mammalian cells.
Expression of rabies virus glycoprotein from a recombinant vaccinia virus.
Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions.
Expression of the F and HN glycoproteins of human parainfluenza virus type 3 by recombinant vaccinia viruses: contributions of the individual proteins to host immunity.
Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: comparison of the individual contributions of the F and G glycoproteins to host immunity.
Expression of the major glycoprotein G of human respiratory syncytial virus from recombinant vaccinia virus vectors.
Expression vector pT7:TKII for the synthesis of authentic biologically active RNA encoding vaccinia virus thymidine kinase.
Failure of poxvirus replication in the presence of an inhibitor of nucleolar RNA synthesis.
Fidelity of homologous recombination in vaccinia virus DNA.
Fine structure analysis and nucleotide sequence of the vaccinia virus thymidine kinase gene.
First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells.
Fluorescent Tagged Vaccinia Virus Genome Allows Rapid and Efficient Measurement of Oncolytic Potential and Discovery of Oncolytic Modulators.
Gene therapy for malignant mesothelioma: beyond the infant years.
Gene translocations in poxviruses: the fowlpox virus thymidine kinase gene is flanked by 15 bp direct repeats and occupies the locus which in vaccinia virus is occupied by the ribonucleotide reductase large subunit gene.
General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.
Generation of reovirus core-like particles in cells infected with hybrid vaccinia viruses that express genome segments L1, L2, L3, and S2.
High-frequency homologous recombination in vaccinia virus DNA.
Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells.
Identification and characterization of an extracellular envelope glycoprotein affecting vaccinia virus egress.
Identification and characterization of the thymidine kinase gene of Yaba virus.
Identification and cloning of the fowlpox virus thymidine kinase gene using vaccinia virus.
Identification of a Bohle iridovirus thymidine kinase gene and demonstration of activity using vaccinia virus.
Identification of the ATP-binding domain of vaccinia virus thymidine kinase.
Identification of vaccinia promoters by heterologous expression of hepatitis B surface antigen in mouse cells infected by recombinant vaccinia viruses.
Immunization with a vaccinia recombinant expressing the F protein protects rabbits from challenge with a lethal dose of rinderpest virus.
Improved recombinant LC16m0 or LC16m8 vaccinia virus successfully expressing hepatitis B surface antigen.
Improved safety of a replication-competent poxvirus-based HIV vaccine with the introduction of the HSV-TK/GCV suicide gene system.
In vivo recognition of orf virus early transcriptional promoters in a vaccinia virus recombinant.
Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells.
Induction of protective immunity in animals vaccinated with recombinant vaccinia viruses that express PreM and E glycoproteins of Japanese encephalitis virus.
Infectious bursal disease virus structural protein VP2 expressed by a fowlpox virus recombinant confers protection against disease in chickens.
Infectious poxvirus vectors have capacity for at least 25 000 base pairs of foreign DNA.
INHIBITION OF THYMIDINE KINASE FORMATION IN LM (TK-) CELLS SIMULTANEOUSLY INFECTED WITH VACCINIA AND A THYMIDINE KINASELESS VACCINIA MUTANT.
Inhibition of vaccinia virus growth by zinc ions: effects on early RNA and thymidine kinase synthesis.
Inhibition of vaccinia virus thymidine kinase by the distal products of its own metabolic pathway.
INHIBITORY EFFECT OF INTERFERON ON THE INDUCTION OF THYMIDINE KINASE IN VACCINIA VIRUS-INFECTED CHICK EMBRYO FIBROBLASTS.
Inhibitory effects of puromycin and fluorophenylalanine on induction of thymidine kinase by vaccinia infected L-cells.
Insertion sites for recombinant vaccinia virus construction: effects on expression of a foreign protein.
Interferon sensitivity of expression of histone H5/H1(0)-vaccinia thymidine kinase fusion genes expressed by recombinant vaccinia viruses is enhanced by shortening the histone sequence.
Intracellular processing of the porcine coronavirus transmissible gastroenteritis virus spike protein expressed by recombinant vaccinia virus.
Intratumoral injection of GM-CSF gene encoded recombinant vaccinia virus elicits potent antitumor response in a mixture melanoma model.
Introduction of foreign DNA into the vaccinia virus genome by in vitro ligation: recombination-independent selectable cloning vectors.
Isolation of cis-acting vaccinia virus DNA fragments promoting the expression of herpes simplex virus thymidine kinase by recombinant viruses.
JX-594, a targeted oncolytic poxvirus for the treatment of cancer.
KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.
Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus.
Locating a nucleotide-binding site in the thymidine kinase of vaccinia virus and of herpes simplex virus by scoring triply aligned protein sequences.
Mapping and identification of the vaccinia virus thymidine kinase gene.
Mapping of a vaccinia host range sequence by insertion into the viral thymidine kinase gene.
Mapping of the vaccinia virus thymidine kinase gene by marker rescue and by cell-free translation of selected mRNA.
Mapping thymidine kinase-deficient mutants of vaccinia virus by marker rescue with hybrid plasmid DNAs containing portions of the HindIII-J fragment of virus DNA.
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.
Morphological and molecular characterization of the poxvirus BeAn 58058.
Multiple-cloning-site plasmids for the rapid construction of recombinant poxviruses.
Novel codon utilization within the vaccinia virus thymidine kinase gene.
Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity.
Nucleotide sequence analysis and expression from recombinant vectors demonstrate that the attachment protein G of bovine respiratory syncytial virus is distinct from that of human respiratory syncytial virus.
Nucleotide sequence analysis of the bovine respiratory syncytial virus fusion protein mRNA and expression from a recombinant vaccinia virus.
Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and comparison with vaccinia virus.
Nucleotide sequence of the thymidine kinase gene of raccoon poxvirus.
Nucleotide sequence of the vaccinia virus thymidine kinase gene and the nature of spontaneous frameshift mutations.
Oncolytic efficacy of thymidine kinase-deleted vaccinia virus strain Guang9.
Oncolytic vaccine virus harbouring the IL-24 gene suppresses the growth of lung cancer by inducing apoptosis.
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment.
One hundred base pairs of 5' flanking sequence of a vaccinia virus late gene are sufficient to temporally regulate late transcription.
Orthopoxvirus DNA in eurasian lynx, sweden.
Passatempo virus, a vaccinia virus strain, Brazil.
Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.
Preclinical Evaluation of the Oncolytic Vaccinia Virus TG6002 by Translational Research on Canine Breast Cancer.
Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus.
Preparation of candidate vaccinia-vectored vaccines for haemorrhagic fever with renal syndrome.
Prevention of vaccinia virus infection in immunodeficient mice by vector-directed IL-2 expression.
Proceedings: Control of thymidine kinase synthesis in the cells infected with IHD strain of vaccinia virus.
Protection of mice with vaccinia virus recombinants that express the rabies nucleoprotein.
Purification of vaccinia virus-induced thymidine kinase activity from [35S]methionine-labeled cells.
Quaternary structure of vaccinia virus thymidine kinase.
Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963.
Recombinant capripoxvirus expressing the hemagglutinin protein gene of rinderpest virus: protection of cattle against rinderpest and lumpy skin disease viruses.
Recombinant vaccinia virus coexpressing the F protein of respiratory syncytial virus (RSV) and interleukin-4 (IL-4) does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes, whereas priming is diminished in the presence of high levels of IL-2 or gamma interferon.
Recombinant vaccinia/Venezuelan equine encephalitis (VEE) virus expresses VEE structural proteins.
Reduced steady-state levels of vaccinia virus-specific early mRNAs in interferon-treated chick embryo fibroblasts.
Regulation of expression and nucleotide sequence of a late vaccinia virus gene.
Regulation of histone H5 and H1 zero gene expression under the control of vaccinia virus-specific sequences in interferon-treated chick embryo fibroblasts.
Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: persistent transgene expression despite antibody generation.
Rescue of Sendai virus from viral ribonucleoprotein-transfected cells by infection with recombinant vaccinia viruses carrying Sendai virus L and P/C genes.
Resistance to human respiratory syncytial virus (RSV) infection induced by immunization of cotton rats with a recombinant vaccinia virus expressing the RSV G glycoprotein.
Safety studies and viral shedding of intramuscular administration of oncolytic vaccinia virus TG6002 in healthy beagle dogs.
Selection of recombinant vaccinia viruses (Tian Tan strain) expressing hepatitis B virus surface antigen by using beta-galactosidase as a marker.
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
Similar genetic organization between a region of fowlpox virus DNA and the vaccinia virus HindIII J fragment despite divergent location of the thymidine kinase gene.
Simultaneous expression of the Lassa virus N and GPC genes from a single recombinant vaccinia virus.
Single capripoxvirus recombinant vaccine for the protection of cattle against rinderpest and lumpy skin disease.
Site-directed mutagenesis of a conserved domain in vaccinia virus thymidine kinase. Evidence for a potential role in magnesium binding.
SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC.
Structure of vaccinia virus early promoters.
Structure of vaccinia virus late promoters.
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design.
Studies on the mechanism of action of interferon: inhibition of thymidine kinase induction in vaccinia virus-infected chick embryo cells.
Substrate specificity of vaccinia virus thymidylate kinase.
Synthesis of vaccinia virus thymidine kinase in microinjected Xenopus oocytes.
Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes.
Target Therapy With Vaccinia Virus Harboring IL-24 For Human Breast Cancer.
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
The 5' noncoding region sequence of the Choristoneura biennis entomopoxvirus spheroidin gene functions as an efficient late promoter in the mammalian vaccinia expression system.
The development and use of a vaccinia-rabies recombinant oral vaccine for the control of wildlife rabies; a link between Jenner and Pasteur.
The gene encoding the late nonstructural 36K protein of vaccinia virus is essential for virus reproduction.
The nucleotide sequence of the chicken thymidine kinase gene and the relationship of its predicted polypeptide to that of the vaccinia virus thymidine kinase.
The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers.
The use of recombinant vaccinia virus to generate monoclonal antibodies against the cell-surface glycoprotein endoglin.
Transactivation by herpes simplex virus proteins ICP4 and ICP0 in vaccinia virus infected cells.
Translation of reovirus RNA species m1 can initiate at either of the first two in-frame initiation codons.
Vaccinia as a vector for gene delivery.
Vaccinia virus DNA ligase is nonessential for virus replication: recovery of plasmids from virus-infected cells.
Vaccinia virus encodes a thymidylate kinase gene: sequence and transcriptional mapping.
Vaccinia virus encodes an active thymidylate kinase that complements a cdc8 mutant of Saccharomyces cerevisiae.
Vaccinia virus expressing IL-37 promotes antitumor immune responses in hepatocellular carcinoma.
Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.
Vaccinia virus recombinants expressing rabiesvirus glycoprotein protect against rabies.
Vaccinia virus thymidine kinase and neighboring genes: mRNAs and polypeptides of wild-type virus and putative nonsense mutants.
Viral chimeric protein including a determinant of myelin basic protein is capable of inducing allergic encephalomyelitis in guinea pigs.
Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins.
[Development of the drug oncolytic immunotherapy based on vaccinia viruses (Vaccinia virus, Orthopoxvirus, Chordopoxvirinae, Poxviridae) against breast cancer.]
[Double recombinants of the vaccinia virus expressing hepatitis B virus surface antigen and herpes simplex virus thymidine kinase]
[Molecular biological study of the vaccinia virus genome. IV. The late nonstructural 36K protein of vaccinia virus is vitally important]
[The immunogenic properties of a recombinant vaccinia virus with an incorporated DNA copy of the 26S RNA of the Venezuelan equine encephalomyelitis virus]
[Therapeutic effect of vaccinia virus secreting granulocyte-macrophage colony-stimulating factor on pulmonary metastatic melanoma]
Vascular Diseases
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
Vesicular Stomatitis
Autonomous Cell Migration to CSF1 Sources via a Synthetic Protein-Based System.
Engineered Proteins Program Mammalian Cells to Target Inflammatory Disease Sites.
Fetal gene transfer using lentiviral vectors: in vivo detection of gene expression by microPET and optical imaging in fetal and infant monkeys.
Genetically engineered vesicular stomatitis virus in gene therapy: application for treatment of malignant disease.
Selective elimination of HIV-1-infected cells by Env-directed, HIV-1-based virus-like particles.
Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
[Vesicular stomatitis virus G-protein retrovector mediated a herpes simplex virus thymidine kinase gene transduction and expression in the human retinal pigment epithelial cells]
Virus Diseases
Acyclovir in mouse cytomegalovirus infections.
Alpha-Herpesvirus Thymidine Kinase Genes Mediate Viral Virulence and Are Potential Therapeutic Targets.
Antiviral activity of a selective ribonucleotide reductase inhibitor against acyclovir-resistant herpes simplex virus type 1 in vivo.
Application of an in vitro assay for serum thymidine kinase: results on viral disease and malignancies in humans.
Effect of a thymidine kinase inhibitor (L-653,180) on antiviral treatment of experimental herpes simplex virus infection in mice.
Expression of a cellular gene cloned in herpes simplex virus: rabbit beta-globin is regulated as an early viral gene in infected fibroblasts.
Immune gene expression profile of Penaeus monodon in response to marine yeast glucan application and white spot syndrome virus challenge.
Induction of thymidine kinase and DNase in varicella-zoster virus-infected cells and kinetic properties of the virus-induced thymidine kinase.
Marine actinomycetes as bioremediators in Penaeus monodon rearing system.
Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes.
N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.
Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA.
Nucleic acid related compounds. 65. New syntheses of 1-(beta-D-arabinofuranosyl)-5(E)-(2-iodovinyl)uracil (IVAraU) from vinylsilane precursors. Radioiodine uptake as a marker for thymidine kinase positive herpes viral infections.
Passatempo virus, a vaccinia virus strain, Brazil.
Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer.
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.
Radiolabeled antiviral drugs and antibodies as virus-specific imaging probes.
Recurrent herpes simplex virus hepatitis after liver retransplantation despite acyclovir therapy.
Regulated expression of stably transfected herpes simplex virus thymidine kinase genes in continuous cell lines expressing a temperature-sensitive mutant form of the immediate-early protein ICP4.
Serum thymidine kinase in transplant patients: its relation to cytomegalovirus activity, renal transplant rejection and its use for monitoring of antiviral therapy.
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
The requirement of simian virus 40 gene A product for the stimulation of cellular thymidine kinase activity after viral infection.
Transient control of a virus-induced immunopathology by genetic immunosuppression.
[Prospects and current data in antiviral chemotherapy]
Vitamin B 12 Deficiency
Serum thymidine kinase in vitamin B12 deficiency.
Vitiligo
Extensive vitiligo after ganciclovir treatment of GvHD in a patient who had received donor T cells expressing herpes simplex virus thymidine kinase.
Vitreoretinopathy, Proliferative
Inhibition of experimental proliferative vitreoretinopathy by retroviral vector-mediated transfer of suicide gene. Can proliferative vitreoretinopathy be a target of gene therapy?
Ocular gene therapy: experimental studies and clinical possibilities.
Wiskott-Aldrich Syndrome
Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: evidence for reactivation of acyclovir-resistant herpes simplex virus.
Recurrent aciclovir-resistant herpes simplex in a child with Wiskott-Aldrich syndrome.
Wolfram Syndrome
Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding protein.
X-Linked Combined Immunodeficiency Diseases
Application of HSVtk suicide gene to X-SCID gene therapy: ganciclovir treatment offsets gene corrected X-SCID B cells.
Zoonoses
Inhibition of B virus (Cercopithecine herpesvirus 1) by Conventional and Experimental Antiviral Compounds.