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ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
?
Herpes simplex virus
-
-
-
-
?
ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
ADP + (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
ATP + 1-(beta-D-arabinofuranosyl)thymine
ADP + 1-(beta-D-arabinofuranosyl)thymine 5'-phosphate
ATP + 1-beta-D-arabinofuranosylthymine
ADP + 1-beta-D-arabinofuranosylthymine 5'-phosphate
-
as active as with 2'-deoxythymidine
-
-
?
ATP + 2',3'-didehydro-2',3'-dideoxythymidine
ADP + 2',3'-didehydro-2',3'-dideoxythymidine 5'-phosphate
-
12% activity compared to thymidine
-
-
?
ATP + 2',3'-dideoxy-2',3'-didehydrothymidine
ADP + 2',3'-dideoxy-2',3'-didehydrothymidine 5'-phosphate
-
-
-
?
ATP + 2',3'-dideoxy-3'-azidothymidine
ADP + 2',3'-dideoxy-3'-azidothymidine 5'-phosphate
-
-
-
?
ATP + 2',3'-dideoxycytidine
ADP + 2',3'-dideoxycytidine 5'-phosphate
ATP + 2',3'-dideoxydehydrothymidine
ADP + 2',3'-dideoxydehydrothymidine 5'-phosphate
ATP + 2',3'-dideoxythymidine
ADP + 2',3'-dideoxythymidine 5'-phosphate
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
ATP + 2'-exo-methanocarba-thymidine
ADP + 2'-exo-methanocarba-thymidine 5'-monophosphate
Herpes simplex virus
-
MCT
-
?
ATP + 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil
ADP + 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil 5'-phosphate
-
-
-
?
ATP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate
ATP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate
ATP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
ATP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate
ATP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
ATP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
ATP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
ATP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
ATP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
ATP + 3'-azido-2',3'-deoxythymidine
ADP + 3'-azido-2',3'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 3'-azido-2',3'-dideoxythymidine
ADP + 3'-azido-2',3'-dideoxythymidine 5'-phosphate
ATP + 3'-azido-3'-deoxythymidine
ADP + 3'-azido-3'-deoxythymidine 5'-phosphate
ATP + 3'-azidothymidine
?
Herpes simplex virus
-
-
-
-
?
ATP + 3'-deoxy-2',3'-didehydro-thymidine
ADP + 3'-deoxy-2',3'-didehydro-thymidine 5'-phosphate
-
-
-
-
?
ATP + 3'-deoxy-2',3'-didehydrothymidine
ADP + 3'-deoxy-2',3'-didehydrothymidine 5'-phosphate
-
-
-
-
?
ATP + 3'-deoxythymidine
ADP + 3'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 3'-fluoro-3'-deoxythymidine
ADP + 3'-fluoro-3'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 3-(benzylcarbamimidoyl)thymidine
ADP + 3-(benzylcarbamimidoyl)thymidine 5'-phosphate
-
14.9% activity compared to thymidine
-
-
?
ATP + 3-(butylcarbamimidoyl)thymidine
ADP + 3-(butylcarbamimidoyl)thymidine 5'-phosphate
-
1.2% activity compared to thymidine
-
-
?
ATP + 3-(phenylcarbamimidoyl)thymidine
ADP + 3-(phenylcarbamimidoyl)thymidine 5'-phosphate
-
1.9% activity compared to thymidine
-
-
?
ATP + 3-(tetrazol-5-ylmethyl)thymidine
ADP + 3-(tetrazol-5-ylmethyl)thymidine 5'-phosphate
-
39.5% activity compared to thymidine
-
-
?
ATP + 3-[1(2)-closo-1,7-carboranylbutyltetrazol-5-ylmethyl]thymidine
ADP + 3-[1(2)-closo-1,7-carboranylbutyltetrazol-5-ylmethyl]thymidine 5'-phosphate
-
63.7% activity compared to thymidine
-
-
?
ATP + 3-[1(2)-closo-1,7-carboranylbutyltetrazol-5-yl]thymidine
ADP + 3-[1(2)-closo-1,7-carboranylbutyltetrazol-5-yl]thymidine 5'-phosphate
-
42.5% activity compared to thymidine
-
-
?
ATP + 3-[1(2)-closo-1,7-carboranylethyltetrazol-5-ylmethyl]thymidine
ADP + 3-[1(2)-closo-1,7-carboranylethyltetrazol-5-ylmethyl]thymidine 5'-phosphate
-
52.4% activity compared to thymidine
-
-
?
ATP + 3-[1(2)-closo-1,7-carboranylethyltetrazol-5-yl]thymidine
ADP + 3-[1(2)-closo-1,7-carboranylethyltetrazol-5-yl]thymidine 5'-phosphate
-
55.6% activity compared to thymidine
-
-
?
ATP + 3-[1(2)-closo-1,7-carboranylpropyltetrazol-5-ylmethyl]thymidine
ADP + 3-[1(2)-closo-1,7-carboranylpropyltetrazol-5-ylmethyl]thymidine 5'-phosphate
-
58.2% activity compared to thymidine
-
-
?
ATP + 3-[1(2)-closo-1,7-carboranylpropyltetrazol-5-yl]thymidine
ADP + 3-[1(2)-closo-1,7-carboranylpropyltetrazol-5-yl]thymidine 5'-phosphate
-
42.9% activity compared to thymidine
-
-
?
ATP + 3-[1(2)-propyltetrazol-5-ylmethyl]thymidine
ADP + 3-[1(2)-propyltetrazol-5-ylmethyl]thymidine 5'-phosphate
-
55.7% activity compared to thymidine
-
-
?
ATP + 3-[1(2)-propyltetrazol-5-yl]thymidine
ADP + 3-[1(2)-propyltetrazol-5-yl]thymidine 5'-phosphate
-
57.6% activity compared to thymidine
-
-
?
ATP + 3-[2-(closo-1,7-carboranyl)ethylcarbamimidoyl]thymidine
ADP + 3-[2-(closo-1,7-carboranyl)ethylcarbamimidoyl]thymidine 5'-phosphate
-
16.3% activity compared to thymidine
-
-
?
ATP + 3-[2-imino-2-(benzylamino)ethyl]thymidine
ADP + 3-[2-imino-2-(benzylamino)ethyl]thymidine 5'-phosphate
-
16.8% activity compared to thymidine
-
-
?
ATP + 3-[2-imino-2-(butylamino)ethyl]thymidine
ADP + 3-[2-imino-2-(butylamino)ethyl]thymidine 5'-phosphate
-
2.3% activity compared to thymidine
-
-
?
ATP + 3-[2-imino-2-(phenylamino)ethyl]thymidine
ADP + 3-[2-imino-2-(phenylamino)ethyl]thymidine 5'-phosphate
-
11.3% activity compared to thymidine
-
-
?
ATP + 3-[2-imino-2-(propylamino)ethyl]thymidine
ADP + 3-[2-imino-2-(propylamino)ethyl]thymidine 5'-phosphate
-
1.9% activity compared to thymidine
-
-
?
ATP + 3-[2-imino-2-[2-(closo-1,7-carboranyl)ethylamino]ethyl]thymidine
ADP + 3-[2-imino-2-[2-(closo-1,7-carboranyl)ethylamino]ethyl]thymidine 5'-phosphate
-
3.0% activity compared to thymidine
-
-
?
ATP + 3-[2-imino-2-[2-(closo-1,7-carboranyl)propylamino]ethyl]thymidine
ADP + 3-[2-imino-2-[2-(closo-1,7-carboranyl)propylamino]ethyl]thymidine 5'-phosphate
-
5.6% activity compared to thymidine
-
-
?
ATP + 3-[3-(closo-1,7-carboranyl)propylcarbamimidoyl]thymidine
ADP + 3-[3-(closo-1,7-carboranyl)propylcarbamimidoyl]thymidine 5'-phosphate
-
15.5% activity compared to thymidine
-
-
?
ATP + 3-[4-(closo-1,7-carboranyl)butylcarbamimidoyl]thymidine
ADP + 3-[4-(closo-1,7-carboranyl)butylcarbamimidoyl]thymidine 5'-phosphate
-
27.3% activity compared to thymidine
-
-
?
ATP + 5-azido-3'-azido-2',3'-dideoxyuridine
ADP + 5-azido-3'-azido-2',3'-dideoxyuridine 5'-monophosphate
Herpes simplex virus
-
-
photoaffinity analog of 3'-azidothymidine
?
ATP + 5-bromo-2'-deoxyuridine
ADP + 5-bromo-2'-deoxyuridine 5'-phosphate
ATP + 5-bromodeoxyuridine
ADP + 5-bromodeoxyuridine 5'-phosphate
-
84% activity compared to thymidine
-
-
?
ATP + 5-chloro-2'-deoxyuridine
ADP + 5-chloro-2'-deoxyuridine 5'-phosphate
ATP + 5-chlorodeoxyuridine
ADP + 5-chlorodeoxyuridine 5'-phosphate
-
110% activity compared to thymidine
-
-
?
ATP + 5-diaza-2'-deoxyuridine
ADP + 5-diaza-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
ATP + 5-fluorodeoxyuridine
ADP + 5-fluorodeoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-hydroxymethyl-2'-deoxyuridine
ADP + 5-hydroxymethyl-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 5-iodo-2'-deoxyuridine
?
5-iodo-2'-deoxyuridine is efficiently phosphorylated by thymidine kinase confirming that these compound enters the active site of the enzyme and acts as alternate substrate
-
-
?
ATP + 5-iodo-2'-deoxyuridine
ADP + 5-iodo-2'-deoxyuridine 5'-phosphate
ATP + 5-iododeoxyuridine
ADP + 5-iododeoxyuridine 5'-phosphate
-
89% activity compared to thymidine
-
-
?
ATP + 5-mercapto-2'-deoxyuridine
ADP + 5-mercapto-2'-deoxyuridine 5'-phosphate
-
ATP as phosphate donor can be replaced by dGTP, dATP, dCTP, GTP, and ITP
-
-
?
ATP + 5-trifluoromethyl-2'-deoxyuridine
ADP + 5-trifluoromethyl-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-trifluoromethyl-2-deoxyuridine
?
5-trifluoromethyl-2-deoxyuridine is efficiently phosphorylated by thymidine kinase confirming that these compound enters the active site of the enzyme and acts as alternate substrate
-
-
?
ATP + 6-aza-2'-deoxythymidine
ADP + 6-aza-2'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine
ADP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-phosphate
-
-
-
-
?
ATP + 9-[(hydroxyethoxy)methyl]guanine
ADP + 9-[(hydroxyethoxy)methyl]guanine 5'-phosphate
-
-
-
-
?
ATP + aciclovir
ADP + aciclovir 5'-phosphate
-
-
-
-
?
ATP + aciclovir monophosphate
?
Herpes simplex virus
-
-
-
-
?
ATP + acyclovir
ADP + acyclovir 5'-phosphate
-
-
-
-
?
ATP + acyclovir
ADP + acyclovir phosphate
ATP + arabinosyl cytosine
?
-
-
-
?
ATP + azidothymidine
?
-
-
-
?
ATP + azidothymidine monophosphate
?
-
-
-
?
ATP + beta-5-ethyl-2'-deoxyuridine
?
beta-5-ethyl-2'-deoxyuridine is efficiently phosphorylated by thymidine kinase confirming that these compound enters the active site of the enzyme and acts as alternate substrate
-
-
?
ATP + beta-L-2',3'-dideoxy-3'-thiacytidine
ADP + beta-L-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
ATP + beta-L-thymidine
ADP + beta-L-thymidine 5'-phosphate
-
less than 5% activity compared to thymidine
-
-
?
ATP + cytosine arabinoside 5'-triphosphate
ADP + thymidine 5'-phosphate
-
-
-
-
?
ATP + deoxyadenosine
ADP + dAMP
ATP + deoxycytidine
ADP + dCMP
ATP + deoxyguanosine
ADP + dGMP
ATP + deoxyinosine
ADP + dIMP
ATP + deoxythymidine
ADP + dTMP
-
ATP as phosphate donor can be replaced by dGTP, dATP, dCTP, GTP, and ITP
-
?
ATP + deoxyuridine
ADP + dUMP
ATP + dideoxyinosine
ADP + dideoxyinosine 5'-phosphate
-
-
-
-
?
ATP + difluorodeoxycytidine
?
-
-
-
?
ATP + difluorodeoxyuridine
?
-
-
-
?
ATP + dioxolane thymidine
ADP + dioxolane thymidine 5'-phosphate
-
-
-
?
ATP + ganciclovir
?
Herpes simplex virus
-
-
-
-
?
ATP + ganciclovir
ADP + ganciclovir phosphate
-
-
-
-
?
ATP + ganciclovir monophosphate
?
Herpes simplex virus
-
-
-
-
?
ATP + guanosine
ADP + GMP
-
1% activity compared to thymidine
-
-
?
ATP + iododeoxyuridine
ADP + iododeoxyuridine 5'-phosphate
-
-
-
-
?
ATP + lobucavir
?
Herpes simplex virus
-
-
-
-
?
ATP + methylthymidine
ADP + methylthymidine 5'-phosphate
-
-
-
-
?
ATP + thymidine
ADP + dTMP
ATP + thymidine
ADP + thymidine 5'-phosphate
ATP + thymidine 5'-phosphate
ADP + thymidine diphosphate
Herpes simplex virus type 4
-
-
-
-
r
ATP + trifluoromethylthymidine
ADP + trifluoromethylthymidine 5-phosphate
-
good substrate, 130% activity compared to thymidine
-
-
?
ATP + uridine
ADP + UMP
-
-
-
-
?
ATP + uridine
ADP + uridine 5'-phosphate
-
-
-
?
ATP + [methyl-3H]thymidine
ADP + [methyl-3H]thymidine 5'-phosphate
-
-
-
-
?
CTP + thymidine
CDP + dTMP
-
-
-
-
?
CTP + thymidine
CDP + thymidine 5'-phosphate
dGTP + thymidine
dGDP + dTMP
-
99% activity compared to ATP
-
-
?
GTP + thymidine
GDP + dTMP
GTP + thymidine
GDP + thymidine 5'-phosphate
TTP + thymidine
TDP + thymidine 5'-phosphate
-
-
-
-
?
UTP + thymidine
UDP + dTMP
additional information
?
-
ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
ADP + (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
-
about 115% of the activity with 2'-deoxythymidine
-
-
?
ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
ADP + (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
ADP + (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
ADP + (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + (E)-5-(2-bromovinyl)-2'-deoxyuridine
ADP + (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-phosphate
-
drug activation by phosphorylation
-
-
?
ATP + 1-(beta-D-arabinofuranosyl)thymine
ADP + 1-(beta-D-arabinofuranosyl)thymine 5'-phosphate
-
-
-
?
ATP + 1-(beta-D-arabinofuranosyl)thymine
ADP + 1-(beta-D-arabinofuranosyl)thymine 5'-phosphate
-
-
-
-
?
ATP + 2',3'-dideoxycytidine
ADP + 2',3'-dideoxycytidine 5'-phosphate
-
-
-
-
?
ATP + 2',3'-dideoxycytidine
ADP + 2',3'-dideoxycytidine 5'-phosphate
-
-
-
-
?
ATP + 2',3'-dideoxydehydrothymidine
ADP + 2',3'-dideoxydehydrothymidine 5'-phosphate
-
-
-
-
?
ATP + 2',3'-dideoxydehydrothymidine
ADP + 2',3'-dideoxydehydrothymidine 5'-phosphate
-
-
-
-
?
ATP + 2',3'-dideoxythymidine
ADP + 2',3'-dideoxythymidine 5'-phosphate
-
-
-
?
ATP + 2',3'-dideoxythymidine
ADP + 2',3'-dideoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
Herpes simplex virus
-
-
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
-
ir
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
ir
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
induction of conformational changes upon ligand binding, overview
-
-
ir
ATP + 2'-deoxycytidine
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
-
ir
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
ir
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
ir
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
induction of conformational changes upon ligand binding, overview
-
-
ir
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
-
ir
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxythymidine
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
Herpes simplex virus
-
-
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
ir
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 2'-deoxyuridine
ADP + 2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate
2.4% activity compared to thymidine
-
-
?
ATP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate
12.3% activity compared to thymidine
-
-
?
ATP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate
3.1% activity compared to thymidine
-
-
?
ATP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate
7.1% activity compared to thymidine
-
-
?
ATP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
2.7% activity compared to thymidine
-
-
?
ATP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
6.5% activity compared to thymidine
-
-
?
ATP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate
2.6% activity compared to thymidine
-
-
?
ATP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
ADP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate
13.7% activity compared to thymidine
-
-
?
ATP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
4.8% activity compared to thymidine
-
-
?
ATP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
11.6% activity compared to thymidine
-
-
?
ATP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
2.9% activity compared to thymidine
-
-
?
ATP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
8.7% activity compared to thymidine
-
-
?
ATP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
2.1% activity compared to thymidine
-
-
?
ATP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
5.5% activity compared to thymidine
-
-
?
ATP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
1.9% activity compared to thymidine
-
-
?
ATP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
7.2% activity compared to thymidine
-
-
?
ATP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
2.2% activity compared to thymidine
-
-
?
ATP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
ADP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate
4.7% activity compared to thymidine
-
-
?
ATP + 3'-azido-2',3'-dideoxythymidine
ADP + 3'-azido-2',3'-dideoxythymidine 5'-phosphate
-
about 5% of the activity with 2'-deoxythymidine
-
-
?
ATP + 3'-azido-2',3'-dideoxythymidine
ADP + 3'-azido-2',3'-dideoxythymidine 5'-phosphate
-
60% activity compared to thymidine
-
-
?
ATP + 3'-azido-2',3'-dideoxythymidine
ADP + 3'-azido-2',3'-dideoxythymidine 5'-phosphate
-
about 165% of the activity with 2'-deoxythymidine
-
-
?
ATP + 3'-azido-3'-deoxythymidine
ADP + 3'-azido-3'-deoxythymidine 5'-phosphate
Q8LDP6, Q9FN47
-
-
-
?
ATP + 3'-azido-3'-deoxythymidine
ADP + 3'-azido-3'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 3'-azido-3'-deoxythymidine
ADP + 3'-azido-3'-deoxythymidine 5'-phosphate
-
-
-
-
?
ATP + 3'-azido-3'-deoxythymidine
ADP + 3'-azido-3'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 3'-azido-3'-deoxythymidine
ADP + 3'-azido-3'-deoxythymidine 5'-phosphate
47.3% activity compared to thymidine
-
-
?
ATP + 3'-azido-3'-deoxythymidine
ADP + 3'-azido-3'-deoxythymidine 5'-phosphate
-
-
-
?
ATP + 3'-azido-3'-deoxythymidine
ADP + 3'-azido-3'-deoxythymidine 5'-phosphate
27.8% activity compared to thymidine
-
-
?
ATP + 5-bromo-2'-deoxyuridine
ADP + 5-bromo-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-bromo-2'-deoxyuridine
ADP + 5-bromo-2'-deoxyuridine 5'-phosphate
-
ATP as phosphate donor can be replaced by dGTP, dATP, dCTP, GTP, and ITP
-
-
?
ATP + 5-bromo-2'-deoxyuridine
ADP + 5-bromo-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-bromo-2'-deoxyuridine
ADP + 5-bromo-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 5-bromo-2'-deoxyuridine
ADP + 5-bromo-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-bromo-2'-deoxyuridine
ADP + 5-bromo-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-chloro-2'-deoxyuridine
ADP + 5-chloro-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-chloro-2'-deoxyuridine
ADP + 5-chloro-2'-deoxyuridine 5'-phosphate
-
ATP as phosphate donor can be replaced by dGTP, dATP, dCTP, GTP, and ITP
-
-
?
ATP + 5-chloro-2'-deoxyuridine
ADP + 5-chloro-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
good substrate, 120% activity compared to thymidine
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
ATP as phosphate donor can be replaced by dGTP, dATP, dCTP, GTP, and ITP
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 5-fluoro-2'-deoxyuridine
ADP + 5-fluoro-2'-deoxyuridine 5'-phosphate
-
-
-
?
ATP + 5-iodo-2'-deoxyuridine
ADP + 5-iodo-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-iodo-2'-deoxyuridine
ADP + 5-iodo-2'-deoxyuridine 5'-phosphate
-
ATP as phosphate donor can be replaced by dGTP, dATP, dCTP, GTP, and ITP
-
-
?
ATP + 5-iodo-2'-deoxyuridine
ADP + 5-iodo-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + 5-iodo-2'-deoxyuridine
ADP + 5-iodo-2'-deoxyuridine 5'-phosphate
-
-
-
-
?
ATP + acyclovir
?
Herpes simplex virus
-
-
-
-
?
ATP + acyclovir
?
Herpes simplex virus
-
poor substrate
-
-
?
ATP + acyclovir
ADP + acyclovir phosphate
-
drug activation by phosphorylation
-
-
?
ATP + acyclovir
ADP + acyclovir phosphate
-
drug activation by phosphorylation, some naturally occurring mutations lead to inability of acyclovir phosphorylation and thus resistance against the drug
-
-
?
ATP + beta-L-2',3'-dideoxy-3'-thiacytidine
ADP + beta-L-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
-
-
-
-
?
ATP + beta-L-2',3'-dideoxy-3'-thiacytidine
ADP + beta-L-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
-
-
-
-
?
ATP + deoxyadenosine
ADP + dAMP
-
-
-
-
?
ATP + deoxyadenosine
ADP + dAMP
-
-
-
-
?
ATP + deoxycytidine
ADP + dCMP
-
substrate for mutant enzymes M42I and L134A
-
-
?
ATP + deoxycytidine
ADP + dCMP
-
7% activity compared to thymidine
-
-
?
ATP + deoxycytidine
ADP + dCMP
-
-
-
-
?
ATP + deoxycytidine
ADP + dCMP
-
-
-
-
?
ATP + deoxycytidine
ADP + dCMP
-
-
-
-
?
ATP + deoxycytidine
ADP + dCMP
-
-
-
-
?
ATP + deoxyguanosine
ADP + dGMP
-
substrate for mutant enzymes S182T and S182A
-
-
?
ATP + deoxyguanosine
ADP + dGMP
-
about 20% activity compared to thymidine
-
-
?
ATP + deoxyguanosine
ADP + dGMP
-
about 20% activity compared to thymidine
-
-
?
ATP + deoxyinosine
ADP + dIMP
-
about 30% activity compared to thymidine
-
-
?
ATP + deoxyinosine
ADP + dIMP
-
about 30% activity compared to thymidine
-
-
?
ATP + deoxyuridine
ADP + dUMP
Q8LDP6, Q9FN47
-
-
-
?
ATP + deoxyuridine
ADP + dUMP
-
69% activity compared to thymidine
-
-
?
ATP + deoxyuridine
ADP + dUMP
-
ATP as phosphate donor can be replaced by dGTP, dATP, dCTP, GTP, and ITP
-
?
ATP + deoxyuridine
ADP + dUMP
-
about 185% activity compared to thymidine
-
-
?
ATP + thymidine
?
-
involved in DNA replication
-
-
?
ATP + thymidine
?
-
-
-
-
?
ATP + thymidine
?
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
Q8LDP6, Q9FN47
best substrate
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dGTP
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dCTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dATP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by CTP
-
-
?
ATP + thymidine
ADP + dTMP
-
100% activity
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by GTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dGTP
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dGTP
-
-
?
ATP + thymidine
ADP + dTMP
-
requirement for high levels of ATP
-
?
ATP + thymidine
ADP + dTMP
-
requirement for high levels of ATP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dATP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by CTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by ITP
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
Herpes simplex virus
-
-
-
-
?
ATP + thymidine
ADP + dTMP
Herpes simplex virus
-
ATP can be substituted by GTP
-
?
ATP + thymidine
ADP + dTMP
Herpes simplex virus
-
ATP can be substituted by dGTP
-
?
ATP + thymidine
ADP + dTMP
Herpes simplex virus
-
ATP can be substituted by dCTP
-
?
ATP + thymidine
ADP + dTMP
Herpes simplex virus
-
ATP can be substituted by dATP
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
100% activity
-
-
?
ATP + thymidine
ADP + dTMP
100% activity
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by GTP
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dGTP
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dGTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by UTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dCTP
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dATP
-
-
?
ATP + thymidine
ADP + dTMP
ATP can be substituted by CTP
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
Murine gammaherpesvirus-68
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by GTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dGTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by ATP-arabinoside
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by UTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dCTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dATP
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dATP
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by GTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dGTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by UTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dATP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by GTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dGTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by UTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dCTP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by dATP
-
-
?
ATP + thymidine
ADP + dTMP
-
ATP can be substituted by CTP
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
Tequatrovirus T4
-
ATP can be substituted by dATP
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
best substrate combination, 100% activity
-
-
?
ATP + thymidine
ADP + dTMP
100% activity
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
-
-
-
?
ATP + thymidine
ADP + dTMP
pyrimidine salvage route
-
-
?
ATP + thymidine
ADP + thymidine 5'-phosphate
-
-
-
ir
ATP + thymidine
ADP + thymidine 5'-phosphate
ATP acts as specific phosphate donor
-
-
?
ATP + thymidine
ADP + thymidine 5'-phosphate
-
-
-
-
?
ATP + thymidine
ADP + thymidine 5'-phosphate
-
-
-
-
?
ATP + thymidine
ADP + thymidine 5'-phosphate
Herpes simplex virus type 4
-
-
-
-
r
ATP + thymidine
ADP + thymidine 5'-phosphate
-
-
-
-
?
ATP + thymidine
ADP + thymidine 5'-phosphate
-
enzyme contains the putative thymidine-binding motif FQRK
-
-
?
ATP + thymidine
ADP + thymidine 5'-phosphate
-
-
-
-
?
ATP + thymidine
ADP + thymidine 5'-phosphate
P03176
-
-
-
?
ATP + thymidine
ADP + thymidine 5'-phosphate
-
-
-
-
?
ATP + thymidine
ADP + thymidine 5'-phosphate
-
-
-
-
?
CTP + thymidine
CDP + thymidine 5'-phosphate
-
-
-
-
?
CTP + thymidine
CDP + thymidine 5'-phosphate
-
-
-
-
?
CTP + thymidine
CDP + thymidine 5'-phosphate
-
-
-
-
?
GTP + thymidine
GDP + dTMP
-
42% activity compared to ATP
-
-
?
GTP + thymidine
GDP + dTMP
-
-
-
-
?
GTP + thymidine
GDP + thymidine 5'-phosphate
-
-
-
-
?
GTP + thymidine
GDP + thymidine 5'-phosphate
-
-
-
-
?
GTP + thymidine
GDP + thymidine 5'-phosphate
-
-
-
-
?
UTP + thymidine
UDP + dTMP
-
17% activity compared to ATP
-
-
?
UTP + thymidine
UDP + dTMP
-
-
-
-
?
UTP + thymidine
UDP + dTMP
-
-
-
-
?
additional information
?
-
-
the wild type enzyme shows no activity with deoxycytidine and deoxyadenosine
-
-
?
additional information
?
-
-
overview: phosphoryl donors
-
-
?
additional information
?
-
-
the type II thymidine kinase ecoded by cowpox virus exhibits a more limited substrate specificity than the type I thymidine kinase encoded by HSV-1
-
-
?
additional information
?
-
-
CTP, diphosphate, uridine, adenosine, cytosine, deoxyguanosine, deoxyguanosine, dTMP, thymine 1-beta-D-arabinofuranoside, 1-beta-D-arabinofuranosylcytosine, acyclovir, and 5-iodo-2'-deoxycytidine are no substrates
-
-
?
additional information
?
-
beta-L-thymidine is poorly phosphorylated by the enzyme
-
-
?
additional information
?
-
-
beta-L-thymidine is poorly phosphorylated by the enzyme
-
-
?
additional information
?
-
does not use UTP, GTP, and TTP as cosubstrates
-
-
?
additional information
?
-
-
does not use UTP, GTP, and TTP as cosubstrates
-
-
?
additional information
?
-
-
overview: thymidine analogs
-
-
?
additional information
?
-
Herpes simplex virus type 4
-
wide substrate specificity phosphorylating pyrimidine nucleosides, nucleoside monophophates, and several nucleoside analogues
-
-
?
additional information
?
-
the cell-cycle-regulated enzyme is important in nucleotide metabolism and an activator of antiviral and anticancer drugs
-
-
?
additional information
?
-
-
the cell-cycle-regulated enzyme is important in nucleotide metabolism and an activator of antiviral and anticancer drugs
-
-
?
additional information
?
-
-
the enzyme is tightly regulated in the cell cycle by multiple mechanism, e.g. by phosphorylation at Ser13 in mitotic-arrested cells, regulation model
-
-
?
additional information
?
-
-
ligand-induced conformational changes in dimeric and tetrameric forms of the enzyme alter the catalytic activity
-
-
?
additional information
?
-
narrow substrate specificity
-
-
?
additional information
?
-
-
narrow substrate specificity
-
-
?
additional information
?
-
-
Val106 has effects on structure-function relation of the enzyme
-
-
?
additional information
?
-
-
no activity with 3-(propylcarbamimidoyl)thymidine and 3-(tetrazol-5-yl)thymidine
-
-
?
additional information
?
-
-
the type II thymidine kinase ecoded by cowpox virus exhibits a more limited substrate specificity than the type I thymidine kinase encoded by HSV-1
-
-
?
additional information
?
-
-
overview thymine nucleosides, 2'-deoxyribonucleosides, arabinosides, ribonucleosides
-
-
?
additional information
?
-
-
the viral enzyme shows a broader substrate specificity than the human host cell enzyme
-
-
?
additional information
?
-
-
modeling of ganciclovir binding into the enzyme crystal structure, overview
-
-
?
additional information
?
-
-
no substrates: ganciclovir, acyclovir, 2'-deoxycytidine
-
-
?
additional information
?
-
-
substrate specificity of wild-type and mutant enzymes, overview
-
-
?
additional information
?
-
overview: nucleoside analogs
-
-
?
additional information
?
-
-
overview: nucleoside analogs
-
-
?
additional information
?
-
-
5-halogenated cytidines, bromouridine, iodouridine, uridine, 5-fluorodeoxycytidine, purine ribonucleosides
-
-
?
additional information
?
-
-
comparison rat liver, Trypanosoma brucei
-
-
?
additional information
?
-
Tequatrovirus T4
-
no phosphorylation of deoxyuridine, 5-halogenated deoxyuridines
-
-
?
additional information
?
-
no activity with uridine, L-thymidine or 2',3'-dideoxyuridine
-
-
?
additional information
?
-
-
no activity with uridine, L-thymidine or 2',3'-dideoxyuridine
-
-
?
additional information
?
-
no activity with uridine, L-thymidine or 2',3'-dideoxyuridine
-
-
?
additional information
?
-
-
domain 1 of thymidine kinase is catalytically inactive but improves substrate binding by domain 2. The enzyme shows the following order of catalytic efficiencies: thymidine > deoxyuridine >> deoxyinosine > deoxyguanosine. The enzyme shows no activity with deoxyadenosine and deoxycytidine
-
-
?
additional information
?
-
-
comparison rat liver, Trypanosoma brucei
-
-
?
additional information
?
-
-
domain 1 of thymidine kinase is catalytically inactive but improves substrate binding by domain 2. The enzyme shows the following order of catalytic efficiencies: thymidine > deoxyuridine >> deoxyinosine > deoxyguanosine. The enzyme shows no activity with deoxyadenosine and deoxycytidine
-
-
?
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(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
(E)-5-(2-bromovinyl)-1-beta-D-(arabinofuranosyl)uracil
-
-
1-(3'-deoxy-5'-O-triphenylmethyl-beta-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)-phenyl)-thiourea
-
-
1-(3,4-dichlorobenzyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
1-benzyl-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
1-beta-D-(arabinofuranosyl)thymine
-
-
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine
-
-
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]thiourea
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]urea
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea
2'-deoxy-3'-aminothymidine
-
5 mM
2'-exo-methanocarba-thymidine
Herpes simplex virus
-
-
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
3'-(1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
-
-
3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine
3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine
3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
-
-
3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
3'-(4-butyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
-
-
3'-(4-chlorobenzylamino)-3'-deoxy-beta-D-thymidine
-
-
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine
-
-
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
-
-
3'-(4-cyclopentylmethyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
-
-
3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
3'-(5-(4-chlorophenyl)-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
-
-
3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine
3'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',3'-dideoxy-3,4-dihydrothymidine
-
-
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine
3'-azido-3'-deoxythymidine
3'-benzylamino-3'-deoxy-beta-D-thymidine
-
-
3'-deoxy-3'-(4-(3,4-dichlorophenyl)-1,2,3-triazol-1-yl)-beta-D-thymidine
-
-
3'-deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine
-
-
3'-deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine
-
-
3'-deoxy-3'-(4-pyridin-2-yl-1,2,3-triazol-1-yl)-beta-D-thymidine
-
-
3'-deoxy-3'-(5-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine
-
-
3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine
3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine
3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine
3'-deoxy-3'-fluorothymidine
-
inhibits thymidine phosphorylation catalyzed by thymidine kinase 2
3'-ethyl-5-methyl-2'-deoxyuridine
-
3'-fluorothymidine
-
inhibits thymidine phosphorylation catalyzed by thymidine kinase 2
3'-hexanoylamino-3'-deoxythymidine
-
very potent inhibitor of thymidine kinase 2
3'-O-ethyl-2'-deoxyuridine
-
3'-O-methyl-2'-deoxyuridine
-
3'-spiro-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)-5-methyluridine
inhibits phosphorylation of 2'-deoxythymidine, IC50: 0.0046 mM
3'-[(3-trifluoromethyl-4-chloro)-benzylamino]-3'-deoxy-beta-D-thymidine
-
-
3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
3-N-methyl-5-iodo-2'-deoxyuridine
-
-
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide
5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine
5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine
5'-O-(4,4'-dimethoxytrityl)thymidine
IC50: 0.468 mM
5'-O-[4-(fluorosulfonyl)benzene-1-sulfonyl]thymidine
-
-
5-(3'-amino-3'-deoxy-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'Nyl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
-
-
5-(3'-amino-3'-deoxy-beta-D-thymidin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
-
-
5-(3'-amino-3'-deoxy-beta-D-thymidin-3'N-yl)-1-benzyl-tetrazole
-
-
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
5-(E)-(2-bromovinyl)uridine
5-azido-2'-deoxyuridine
Herpes simplex virus
-
50% photoincorporation inhibition of wild-type enzyme at 0.003 mM, 50% photoincorporation inhibition of C336Y mutant at 0.05 mM
5-azido-2'-deoxyuridine-5'-monophosphate
Herpes simplex virus
-
50% photoincorporation inhibition of wild-type enzyme at 0.05 mM, 50% photoincorporation inhibition of C336Y mutant at 0.135 mM
5-benzylamino-(3'-deoxy-beta-D-thymidin-3'N-yl)-tetrazole
-
-
5-bromovinyldeoxyuridine
Herpes simplex virus
-
50% photoincorporation inhibition of wild-type enzyme at 0.0015 mM, 50% photoincorporation inhibition of C336Y mutant above 0.025 mM
5-Chlorodeoxyuridine
-
competitive to thymidine
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
5-fluoro-2'-deoxyuridine
concentration dependent reduction of activity
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
5-iodo-2'-deoxyuridine
potent inhibitor
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione
5-propyl-2'-deoxyuridine
-
5-trifluoromethyl-2-deoxyuridine
potent inhibitor
5-Trifluoromethyldeoxyuridine
-
competitive to thymidine
5-[(4-chloro-3-trifluoromethylphenyl)amino]-1-(3'-deoxy-beta-D-thymidin-3'N-yl)-tetrazole
-
-
5-[(E)-2-bromoethenyl]-2'-O-decanoyluridine
competitive with respect to 2'-deoxythymidine, IC50: 0.0012 mm
5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine
5-[amino-(4-chloro-3-trifluoromethylphenyl)]-1-(3'-deoxy-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-tetrazole
-
-
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine
aciclovir
Herpes simplex virus
-
competitive inhibitor
acyclovir H-phosphonate
-
-
alpha-D-5-ethyl-2'-deoxyuridine
-
ammoniumsulfate
Herpes simplex virus
-
50% inhibition at 200 mM
beta-D-5-ethyl-2'-deoxyuridine
potent inhibitor
beta-L-thymidine
potent inhibitor
dATP
-
strong feedback inhibition, tight binding at the active site in stoichiometric amount
dGDP
-
competitive to ATP
EDTA
-
complete incactivation at 2.5 mM
iododeoxycytidine
Herpes simplex virus
-
-
Mg2+
Tequatrovirus T4
-
non-competitive
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
N-(3'-deoxy-beta-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-benzylguanidine
-
-
N-(3'-deoxy-beta-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-guanidine
-
-
N-(3'-deoxy-beta-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine
-
-
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
N-methyl-4-[[[8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)octyl]oxy](diphenyl)methyl]benzamide
-
-
N-methyl-4-[{[8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)octyl]oxy}(diphenyl)methyl]benzamide
-
-
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine
P1-(5'-adenosyl)-P5-(5'-thymidyl)pentaphosphate
-
P1-(Adenosine-5')-P3-(thymidine-5')-triphosphate
-
-
P1-(adenosine-5')-P4-(thymidine-5')-tetraphosphate
-
-
P1-(Adenosine-5')-P5-(thymidine-5')-pentaphosphate
-
-
P1-(Adenosine-5')-P6-(thymidine-5')-hexaphosphate
-
-
potassium phosphate
-
80% inhibition at 50 mM
sulfate
-
competitive inhibitor of ATP binding
thymidylate
Herpes simplex virus
-
50% photoincorporation inhibition of wild-type and C336Y mutant enzyme at 0.0125 mM
trifluridine
concentration dependent reduction of activity
W7
slight inhibitory in presence of calmodulin
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate
IC50: 0.028 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate
-
IC50: above 0.5 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate
IC50: 0.03 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate
-
IC50: above 0.5 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate
IC50: 0.0046 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate
-
IC50: 0.281 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate
IC50: 0.019 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate
-
IC50: above 0.5 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate
IC50: 0.011 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate
-
IC50: 0.42 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate
IC50: 0.04 mM
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate
-
IC50: above 0.5 mM
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
IC50: 0.265 mM
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
-
IC50: above 0.5 mM
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
IC50: 0.371 mM
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
-
IC50: above 0.5 mM
1-(3,4-dichlorobenzyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
-
1-(3,4-dichlorobenzyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
P03176
-
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
-
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
P03176
-
1-benzyl-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
-
1-benzyl-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
P03176
-
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
IC50: 0.18 mM
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
IC50: 0.18 mM
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
IC50: 0.057 mM
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
IC50: 0.057 mM
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
IC50: 0.022 mM
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
IC50: above 0.5 mM
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
IC50: 0.0035 mM; IC50: above 0.5 mM
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
IC50: 0.0035 mM
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine
IC50: 0.01 mM
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine
-
IC50: above 0.5 mM
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
IC50: 0.173 mM
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
IC50: 0.224 mM
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
IC50: 0.017 mM
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
IC50: 0.013 mM
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
IC50: 0.0036 mM
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
IC50: 0.0012 mM
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]thiourea
-
-
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]thiourea
P03176
-
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]urea
-
-
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]urea
P03176
-
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
-
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
P03176
-
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea
-
-
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea
P03176
-
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
IC50: 0.023 mM
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
-
IC50: 0.198 mM
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
IC50: 0.0041 mM
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
-
IC50: 0.119 mM
3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
-
3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
-
3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine
-
3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine
-
3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
-
3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
-
3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
-
3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine
-
-
3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine
P03176
-
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine
-
inhibits thymidine phosphorylation catalyzed by thymidine kinase 2
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine
-
inhibits thymidine phosphorylation catalyzed by thymidine kinase 2
3'-azido-3'-deoxythymidine
-
3'-azido-3'-deoxythymidine
-
3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine
-
-
3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine
P03176
-
3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine
-
-
3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine
P03176
-
3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine
-
-
3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine
P03176
-
3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
-
-
3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
P03176
-
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
-
-
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
P03176
-
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide
IC50: 0.44 mM
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide
-
IC50: 0.175 mM
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide
IC50: 0.194 mM
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide
-
IC50: 0.191 mM
5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine
-
-
5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine
P03176
-
5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine
-
-
5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine
P03176
-
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
IC50: 0.0013 mM; IC50: 0.1 mM
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
-
IC50: above 0.5 mM
5-(E)-(2-bromovinyl)uridine
inhibits phosphorylation of 2'-deoxythymidine
5-(E)-(2-bromovinyl)uridine
-
-
5-bromodeoxyuridine
-
-
5-bromodeoxyuridine
-
competitive to thymidine
5-bromodeoxyuridine
-
competitive to thymidine
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
IC50: 0.02 mM
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
-
IC50: above 0.5 mM
5-fluorodeoxyuridine
-
-
5-fluorodeoxyuridine
-
competitive to thymidine
5-fluorodeoxyuridine
-
competitive to thymidine
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
IC50: 0.0046 mM
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
-
IC50: 0.048 mM
5-iododeoxyuridine
-
competitive to thymidine
5-iododeoxyuridine
-
competitive to thymidine
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
IC50: 0.025 mM
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
-
IC50: 0.003 mM
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
IC50: 0.491 mM
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
-
IC50: 0.491 mM
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
IC50: 0.0023 mM; IC50: above 0.5 mM
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
-
IC50: 0.0023 mM
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine
IC50: 0.484 mM
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine
-
IC50: above 0.5 mM
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
IC50: 0.0015 mM; IC50: above 0.1 mM
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
-
IC50: 0.045 mM
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione
IC50: 0.404 mM
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione
-
IC50: 0.0031 mM
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione
IC50: 0.0033 mM
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione
-
IC50: 0.01 mM
5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine
IC50: 0.006 mM
5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine
-
-
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide
IC50: 0.019 mM
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide
-
IC50: 0.0034 mM
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine
IC50: above 0.5 mM
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine
-
IC50: above 0.5 mM
acyclovir
Herpes simplex virus
-
syn. 9-[(2-hydroxyethoxy)methyl]guanine
acyclovir
Herpes simplex virus
-
50% photoincorporation inhibition of wild-type enzyme at 0.05 mM, 50% photoincorporation inhibition of C336Y mutant above 0.3 mM
ADP
-
-
ATP
Herpes simplex virus
-
50% photoincorporation inhibition of wild-type enzyme at 0.15 mM, 50% photoincorporation inhibition of C336Y mutant above 1 mM
ATP
Tequatrovirus T4
-
non-competitive
Ba2+
-
-
Ba2+
Tequatrovirus T4
-
0.29 mM
Caffeine
-
competitive to ATP, 75% inhibition at 20 mM
Caffeine
-
competitive to ATP
dCTP
-
mitochondrial enzyme
dCTP
-
30-45% inhibition of mitochondrial enzyme at 0.6 or 1 mM, no inhibition of cytosolic enzyme
dCTP
-
80% inhibition of adult enzyme at 1 mM, almost no inhibition of fetal enzyme
dCTP
-
strong feedback inhibition, tight binding at the active site in stoichiometric amount
deoxcytidine
-
deoxcytidine
poor inhibitor
deoxyuridine
-
-
deoxyuridine
-
competitive to thymidine
dTDP
-
83% inhibition at 0.1 mM
dTDP
-
competitive to ATP
dTMP
-
8% inhibition at 0.1 mM
dTMP
-
competitive to ATP
dTMP
-
competitive to thymidine
dTTP
-
84% inhibition at 0.1 mM
dTTP
-
50-90% inhibition at 0.2-0.8 mM; competitive to thymidine
dTTP
-
competitive feedback inhibition
dTTP
-
strong feedback inhibition, tight binding at the active site in stoichiometric amount
dTTP
feedback inhibitor, binds tightly to the enzyme at the active site
dTTP
competitive feedback inhibition, binding structure analysis
dTTP
-
binds to the active site
dTTP
binds to the active site
dTTP
-
non-competitive with thymidine, competitive to ATP
dTTP
Tequatrovirus T4
-
inhibition dependent on pH
dTTP
-
competitive feedback inhibition, binding structure analysis
dTTP
binds to the active site
dUTP
-
-
dUTP
-
competitive to ATP
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
IC50: 0.46 mM
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
-
IC50: above 0.5 mM
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
IC50: 0.353 mM
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
-
IC50: above 0.5 mM
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
IC50: 0.318 mM
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
-
IC50: above 0.5 mM
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
IC50: 0.268 mM
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
-
IC50: above 0.5 mM
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
IC50: 0.238 mM
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
-
IC50: above 0.5 mM
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
IC50: 0.038 mM
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
-
IC50: 0.043 mM
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide
IC50: 0.027 mM
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide
-
IC50: 0.115 mM
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide
IC50: 0.028 mM
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide
-
IC50: 0.072 mM
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide
IC50: 0.033 mM
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide
-
IC50: 0.131 mM
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
IC50: 0.287 mM
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
-
IC50: above 0.5 mM
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
IC50: 0.208 mM
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
-
IC50: 0.495 mM
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
IC50: 0.075 mM
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
-
IC50: 0.275 mM
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine
IC50: above 0.5 mM
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine
-
IC50: above 0.5 mM
penciclovir
-
penciclovir
-
three PCV-resistant FHV-1 variants selected in vitro carry mutations in the TK gene. Penciclovir is a potent selective inhibitor of Feline herpesvirus-1. The virus-encoded thymidine kinase is an important determinant of the virus susceptibility to nucleoside analogues
suramin
-
-
thymidine
Herpes simplex virus
-
50% photoincorporation inhibition of wild-type enzyme at 0.003 mM, 50% photoincorporation inhibition of C336Y mutant at 0.05 mM
thymidine
inhibition of deoxycytidine kinase activity
TTP
-
-
TTP
-
83% inhibition at 1 mM, 43% inhibition at 0.1 mM, 15% inhibition at 0.01 mM
Zn2+
-
-
Zn2+
Tequatrovirus T4
-
1.1 mM and 2.9 mM
additional information
not inhibited by D-5-(bromovinyl)-2'-deoxyuridine, L-5-(bromovinyl)-2'-deoxyuridine, and 2-phenylamino-9-(4-hydroxybutyl)-6-oxopurine
-
additional information
-
not inhibited by D-5-(bromovinyl)-2'-deoxyuridine, L-5-(bromovinyl)-2'-deoxyuridine, and 2-phenylamino-9-(4-hydroxybutyl)-6-oxopurine
-
additional information
-
no inhibition: phenylmethylsulfonylfluoride
-
additional information
-
overview: deoxythymidine analogs
-
additional information
Herpes simplex virus
-
structural requirements of bromine substituted 5-heteroaromatic 2'-deoxyuridines as antiviral agents
-
additional information
Herpes simplex virus
-
synthesis of tricarbonyl rhenium and technetium complexes of a 5-carboxamide 5-ethyl-2'-deoxyuridine for selective inhibition of herpes simplex virus thymidine kinase
-
additional information
-
bisubstrate analogs with adenosine and thymidine joined at their 5' positions by polyphorphoryl linkages of varying lengths can serve as inhibitors
-
additional information
-
overview: purine nucleotides, pyrimidine nucleotides
-
additional information
-
no inhibition: AMP, CMP, GMP, putrescine, spermine, spermidine
-
additional information
-
5'-derivatives of thymidine
-
additional information
-
inhibition potency of dNTPs in descending order: dTTP, dCTP, dATP, inhibitor binding structurally stabilizes the enzyme, induction of conformational changes upon ligand binding, overview
-
additional information
-
at physiological relevant concentration deoxycytidine phosphorylation is not inhibited by 3-azido-3'-deoxythmidine or 3'-fluorothymidine
-
additional information
-
5'-derivatives of thymidine
-
additional information
-
structure-aided design of a series of substituted 3'- or 5'-thiourea derivatives of beta- and alpha-thymidine, respectively, as thymidine monophosphate kinase inhibitors
-
additional information
-
at physiological relevant concentration deoxycytidine phosphorylation is not inhibited by 3'-azido-3'-deoxythmidine or 3'-fluorothymidine
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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0.05
2',3'-didehydro-2',3'-dideoxythymidine
-
at pH 7.8 and 25°C
0.075
2',3'-dideoxy-2',3'-didehydrothymidine
37°C, pH not specified in the publication
0.00065 - 0.0087
2',3'-dideoxy-3'-azidothymidine
0.03
2',3'-dideoxythymidine
37°C, pH not specified in the publication
0.004 - 0.025
2'-deoxycytidine
0.0011 - 0.33
2'-deoxythymidine
0.0015 - 0.011
2'-deoxyuridine
0.132
2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil
37°C, pH not specified in the publication
0.032
3'-azido-2',3'-dideoxythymidine
-
at pH 7.8 and 25°C
0.00038 - 2.318
3'-azido-3'-deoxythymidine
0.0563
3-[1(2)-closo-1,7-carboranylbutyltetrazol-5-ylmethyl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.0174
3-[1(2)-closo-1,7-carboranylbutyltetrazol-5-yl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.0318
3-[1(2)-closo-1,7-carboranylethyltetrazol-5-ylmethyl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.0356
3-[1(2)-closo-1,7-carboranylethyltetrazol-5-yl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.0552
3-[1(2)-closo-1,7-carboranylpropyltetrazol-5-ylmethyl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.0799
3-[1(2)-closo-1,7-carboranylpropyltetrazol-5-yl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.0373
3-[1(2)-propyltetrazol-5-ylmethyl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.0552
3-[1(2)-propyltetrazol-5-yl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.002
5-bromo-2'-deoxyuridine
pH 7.4, 25°C
0.001 - 0.04
5-fluoro-2'-deoxyuridine
0.03
5-fluorodeoxyuridine
-
full-length enzyme, at pH 7.8 and 37°C
0.0967
5-hydroxymethyl-2'-deoxyuridine
pH 7.4, 25°C
0.0012
5-iodo-2'-deoxyuridine
-
-
0.011
aciclovir monophosphate
Herpes simplex virus
-
-
0.00337 - 0.417
acyclovir
0.29
beta-L-thymidine
-
at pH 7.8 and 25°C
8.4
deoxyadenosine
-
full-length enzyme, at pH 7.8 and 37°C
0.003 - 0.568
deoxycytidine
2.6
deoxyguanosine
-
full-length enzyme, at pH 7.8 and 37°C
2.5
deoxyinosine
-
full-length enzyme, at pH 7.8 and 37°C
0.0017
deoxythymidine
-
-
0.0047 - 0.43
deoxyuridine
0.066
difluorodeoxycytidine
-
0.029
difluorodeoxyuridine
-
0.114
dioxolane thymidine
37°C, pH not specified in the publication
0.00333 - 0.473
ganciclovir
0.12
ganciclovir monophosphate
Herpes simplex virus
-
-
0.022
trifluoromethylthymidine
-
at pH 7.8 and 25°C
additional information
additional information
-
0.00065
2',3'-dideoxy-3'-azidothymidine
37°C, pH not specified in the publication
0.0087
2',3'-dideoxy-3'-azidothymidine
82°C, pH not specified in the publication
0.004
2'-deoxycytidine
-
dNTP-free recombinant dimeric enzyme, pH 7.5, 25°C
0.0049
2'-deoxycytidine
-
dNTP-free recombinant tetrameric enzyme, pH 7.5, 25°C
0.018
2'-deoxycytidine
tetrameric enzyme, pH 7.5, 25°C
0.025
2'-deoxycytidine
dimeric enzyme, pH 7.5, 25°C
0.0011
2'-deoxythymidine
pH 7.4, 25°C
0.0058
2'-deoxythymidine
-
dNTP-free recombinant dimeric enzyme, pH 7.5, 25°C
0.0065
2'-deoxythymidine
-
dNTP-free recombinant tetrameric enzyme, pH 7.5, 25°C
0.016
2'-deoxythymidine
-
37°C, pH 7.6
0.025
2'-deoxythymidine
-
pH 8.0, 37°C
0.041
2'-deoxythymidine
-
37°C, pH 7.6
0.05
2'-deoxythymidine
tetrameric enzyme, pH 7.5, 25°C
0.054
2'-deoxythymidine
dimeric enzyme, pH 7.5, 25°C
0.33
2'-deoxythymidine
-
37°C, pH 7.6
0.0015
2'-deoxyuridine
37°C, pH not specified in the publication
0.011
2'-deoxyuridine
pH 7.4, 25°C
0.00038
3'-azido-3'-deoxythymidine
Q8LDP6, Q9FN47
isoform TK1b, pH and temperature not specified in the publication
0.00043
3'-azido-3'-deoxythymidine
mutant enzyme T163S, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.00052
3'-azido-3'-deoxythymidine
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.0027
3'-azido-3'-deoxythymidine
Q8LDP6, Q9FN47
isoform TK1a, pH and temperature not specified in the publication
0.003
3'-azido-3'-deoxythymidine
pH 7.4, 25°C
0.012
3'-azido-3'-deoxythymidine
-
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.015
3'-azido-3'-deoxythymidine
-
37°C, pH 7.6
0.018
3'-azido-3'-deoxythymidine
-
mutant enzyme S182T, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.033
3'-azido-3'-deoxythymidine
mutant enzyme L124A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.05
3'-azido-3'-deoxythymidine
-
37°C, pH 7.6
0.204
3'-azido-3'-deoxythymidine
mutant enzyme M28A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.254
3'-azido-3'-deoxythymidine
mutant enzyme M28I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.406
3'-azido-3'-deoxythymidine
-
mutant enzyme S182A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.6
3'-azido-3'-deoxythymidine
-
37°C, pH 7.6
2.318
3'-azido-3'-deoxythymidine
-
mutant enzyme M42I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.001
5-fluoro-2'-deoxyuridine
37°C, pH not specified in the publication
0.0057
5-fluoro-2'-deoxyuridine
pH 7.4, 25°C
0.04
5-fluoro-2'-deoxyuridine
-
at pH 7.8 and 25°C
0.00337
acyclovir
Herpes simplex virus
-
37°C, mutant SR26
0.0056
acyclovir
Herpes simplex virus
-
37°C, mutant SR11
0.00979
acyclovir
Herpes simplex virus
-
37°C, mutant SR39
0.417
acyclovir
Herpes simplex virus
-
37°C, wild-type
0.0001
ATP
-
two active sites for ATP
0.0001
ATP
-
ATP in form of MgATP2-
0.0013
ATP
Herpes simplex virus
-
pH 7.6, 37°C, mutant C336Y
0.0028
ATP
-
dNTP-free recombinant dimeric enzyme, pH 7.5, 25°C
0.0028
ATP
-
ATP in form of MgATP2-
0.0047
ATP
dimeric enzyme, pH 7.5, 25°C
0.0059
ATP
-
dNTP-free recombinant tetrameric enzyme, pH 7.5, 25°C
0.0059
ATP
-
ATP in form of MgATP2-
0.0109
ATP
tetrameric enzyme, pH 7.5, 25°C
0.013
ATP
Herpes simplex virus
-
pH 7.6, with deoxycytidine
0.021
ATP
Herpes simplex virus
-
pH 7.6, with deoxyuridine
0.025
ATP
wild-type, thymidine as substrate, pH 7.6
0.03
ATP
Herpes simplex virus
-
pH 7.6, 37°C, wild-type
0.03
ATP
-
recombinant wild-type enzyme, pH 7.5, 37°C
0.037
ATP
wild-type, deoxycytidine as substrate, pH 7.6
0.04
ATP
37°C, pH not specified in the publication
0.041
ATP
-
recombinant mutant T298S, pH 7.5, 37°C
0.049
ATP
-
recombinant mutant G294A, pH 7.5, 37°C
0.058
ATP
K0.5 value, Hill coefficient 1.6, pH 7.4, 25°C
0.059
ATP
I212 mutant, deoxycytidine as substrate, pH 7.6
0.07
ATP
-
cytosolic enzyme, pH 7.5, 37°C
0.076
ATP
-
pH 8, 25°C or 37°C
0.08
ATP
H121N mutant, thymidine as substrate, pH 7.6
0.088
ATP
-
recombinant mutant K297R, pH 7.5, 37°C
0.095
ATP
I212 mutant, thymidine as substrate, pH 7.6
0.098
ATP
-
thymidine kinase domain 2, with 0.05 mM thymidine as cosubstrate, at pH 7.8 and 37°C
0.1
ATP
-
mitochondrial enzyme, pH 7.5, 37°C
0.11
ATP
-
mitochondrial enzyme, pH 7.5, 37°C
0.118
ATP
Herpes simplex virus
-
-
0.14
ATP
-
at pH 7.8 and 25°C
0.162
ATP
H121N mutant, deoxycytidine as substrate, pH 7.6
0.18
ATP
-
full-length enzyme, with 0.0005 mM thymidine as cosubstrate, at pH 7.8 and 37°C
0.187
ATP
82°C, pH not specified in the publication
0.21
ATP
-
full-length enzyme, with 0.05 mM thymidine as cosubstrate, at pH 7.8 and 37°C
0.22
ATP
-
full-length enzyme, with 0.005 mM thymidine as cosubstrate, at pH 7.8 and 37°C
0.32
ATP
-
full-length enzyme, with 0.5 mM deoxyinosine as cosubstrate, at pH 7.8 and 37°C
0.9
ATP
-
two active sites for ATP
0.9
ATP
-
ATP in form of MgATP2-
2.6
ATP
-
at concentrations above 1 mM, pH 8, 37°C
20
ATP
-
at concentrations below 1 mM, pH 8, 37°C
0.049
CTP
-
recombinant wild-type enzyme, pH 7.5, 37°C
0.057
CTP
-
about, recombinant mutant T298S, pH 7.5, 37°C
0.088
CTP
-
recombinant mutant G294A, pH 7.5, 37°C
0.108
CTP
-
recombinant mutant K297R, pH 7.5, 37°C
0.003
deoxycytidine
-
mitochondrial enzyme, pH 7.5, 37°C
0.0036
deoxycytidine
-
mutant enzyme M42I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.006
deoxycytidine
-
pH 7.4, 37°C
0.011
deoxycytidine
wild-type and H121N mutant, pH 7.6
0.0115
deoxycytidine
mTK2-55 pH 7.6
0.0236
deoxycytidine
mTK2-39 pH 7.6
0.0251
deoxycytidine
mTK2 pH 7.6
0.0414
deoxycytidine
-
pH and temperature not specified in the publication
0.106
deoxycytidine
Herpes simplex virus
-
pH 7.6
0.568
deoxycytidine
I212 mutant, pH 7.6
0.0047
deoxyuridine
Herpes simplex virus
-
pH 7.6
0.0066
deoxyuridine
Q8LDP6, Q9FN47
isoform TK1b, pH and temperature not specified in the publication
0.015
deoxyuridine
Q8LDP6, Q9FN47
isoform TK1a, pH and temperature not specified in the publication
0.08
deoxyuridine
-
full-length enzyme, at pH 7.8 and 37°C
0.118
deoxyuridine
-
at pH 7.8 and 25°C
0.43
deoxyuridine
-
thymidine kinase domain 2, at pH 7.8 and 37°C
0.00333
ganciclovir
Herpes simplex virus
-
37°C, mutant SR39
0.00614
ganciclovir
Herpes simplex virus
-
37°C, mutant SR11
0.01755
ganciclovir
Herpes simplex virus
-
37°C, mutant SR26
0.0476
ganciclovir
Herpes simplex virus
-
37°C, wild-type
0.05
ganciclovir
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125E
0.069
ganciclovir
Herpes simplex virus
-
pH 7.6, 37°C, wild-type
0.473
ganciclovir
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125N
0.041
GTP
-
recombinant wild-type enzyme, pH 7.5, 37°C
0.043
GTP
-
about, recombinant mutant K297R, pH 7.5, 37°C
0.045
GTP
-
recombinant mutant T298S, pH 7.5, 37°C
0.069
GTP
-
recombinant mutant G294A, pH 7.5, 37°C
0.00015
thymidine
-
pH 8.5, 30°C
0.0002
thymidine
Herpes simplex virus
-
pH 7.2, wild-type
0.00023
thymidine
P03176
mutant enzyme P12N/H13I, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.00027
thymidine
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.0003
thymidine
-
pH 7.5, recombinant mutant V106H, in absence of ATP
0.0003
thymidine
-
pH 7.5, recombinant mutants V106A and V106G, in presence of ATP
0.0003
thymidine
in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.00038
thymidine
Herpes simplex virus
-
37°C, wild-type
0.0004
thymidine
-
pH 7.5, recombinant mutants V106L and V106G, in absence of ATP
0.0004
thymidine
-
pH 7.5, recombinant mutants V106L, V106H and V106T, in presence of ATP
0.00044
thymidine
P03176
wild type enzyme, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0005
thymidine
37°C, pH not specified in the publication
0.0005
thymidine
in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.00054
thymidine
-
pH 8.0, 37°C, recombinant wild-type enzyme
0.0006
thymidine
Herpes simplex virus
-
-
0.0006
thymidine
-
pH 7.5, recombinant mutant V106M, in absence or presence of ATP
0.0006
thymidine
-
pH 7.5, recombinant wild-type enzyme, in presence of ATP
0.0006
thymidine
in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0006
thymidine
in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0006
thymidine
in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0006
thymidine
subunit alpha, in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.00062
thymidine
Q8LDP6, Q9FN47
isoform TK1a, pH and temperature not specified in the publication
0.0007
thymidine
-
TK-A, below 0.004 mM deoxythymidine, 25°C
0.0007
thymidine
-
pH 7.5, recombinant mutant V106K, in absence of ATP
0.0007
thymidine
in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0007
thymidine
subunit alpha, in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0008
thymidine
-
pH 7.5, recombinant mutant V106Q, in absence or presence of ATP
0.0009
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, wild-type
0.0009
thymidine
-
pH 7.5, recombinant mutant V106I, in presence of ATP
0.0009
thymidine
in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0009
thymidine
subunit beta, in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0009
thymidine
subunit beta, in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.00095
thymidine
Herpes simplex virus
-
37°C, mutant SR11
0.001
thymidine
-
TK-C, below 0.004 mM deoxythymidine, 25°C
0.001
thymidine
82°C, pH not specified in the publication
0.0012
thymidine
-
pH 7.5, recombinant mutant V106K, in presence of ATP
0.0012
thymidine
in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0013
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, wild-type
0.0013
thymidine
Herpes simplex virus
-
37°C, mutant SR26
0.0013
thymidine
-
mutant enzyme S182T, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.0014
thymidine
in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0014
thymidine
Q8LDP6, Q9FN47
isoform TK1b, pH and temperature not specified in the publication
0.0014
thymidine
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.0016
thymidine
in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.002
thymidine
in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0022
thymidine
-
pH 8, 37°C
0.0023
thymidine
-
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.0024
thymidine
in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0025
thymidine
Herpes simplex virus
-
pH 7.2, Y101F mutant
0.0025
thymidine
in the presence of 2.5 mM ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0026
thymidine
-
cytoplasmic enzyme, pH 7.5, 37°C
0.0026
thymidine
-
mitochondrial enzyme, pH 7.5, 37°C
0.00264
thymidine
Herpes simplex virus
-
37°C, mutant SR39
0.003
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125N
0.0034
thymidine
mTK2 pH 7.6
0.0039
thymidine
P03176
mutant enzyme P12N, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0039
thymidine
-
thymidine kinase-2 mutant enzyme I59Y, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0041
thymidine
-
pH 8, 25°C or 37°C
0.0043
thymidine
-
wild type thymidine kinase-2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0049
thymidine
mTK2-39 pH 7.6
0.0049
thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.005
thymidine
-
pH 7.4, 37°C
0.005 - 0.0052
thymidine
-
mitochondrial enzyme, pH 7.5, 37°C
0.0051
thymidine
-
thymidine kinase-2 mutant enzyme I59V, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0056
thymidine
-
pH 8.0, 37°C, Km is markedly dependent on pH
0.0056
thymidine
-
thymidine kinase-2 mutant enzyme I59L, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0057
thymidine
H121N mutant, pH 7.6
0.00596
thymidine
-
pH 8.0, 37°C, recombinant mutant S13D
0.006
thymidine
-
thymidine kinase-2 mutant enzyme I59H, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.007
thymidine
-
TK-A, above 0.004 mM deoxythymidine, 25°C
0.0073
thymidine
mTK2-55 pH 7.6
0.0078
thymidine
-
full-length enzyme, at pH 7.8 and 37°C
0.008
thymidine
in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.009
thymidine
-
pH 7.8, 37°C
0.01
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, mutant C336Y
0.01
thymidine
-
cytosolic enzyme, pH 7.5, 37°C
0.01
thymidine
-
TK-C, above 0.004 mM deoxythymidine, 25°C
0.012
thymidine
in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.0127
thymidine
-
pH 7.5, recombinant mutant V106A, in absence of ATP
0.013
thymidine
wild-type, pH 7.6
0.016
thymidine
in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.017
thymidine
in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.017
thymidine
in the absence of ATP, in 50 mM Tris/HCl (pH 8.0), 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, temperature not specified in the publication
0.018
thymidine
I212 mutant, pH 7.6
0.0188
thymidine
-
pH and temperature not specified in the publication
0.02
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125E
0.0271
thymidine
-
pH 7.5, recombinant wild-type enzyme, in absence of ATP
0.0294
thymidine
-
pH 7.5, recombinant mutant V106I, in absence of ATP
0.036
thymidine
mutant enzyme L124A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.037
thymidine
P03176
mutant enzyme H13I/Y127F, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.043
thymidine
-
pH 7.5, recombinant mutant V106T, in absence of ATP
0.046
thymidine
-
thymidine kinase domain 2, at pH 7.8 and 37°C
0.048
thymidine
-
at pH 7.8 and 25°C
0.057
thymidine
-
pH 7, 37°C
0.059
thymidine
mutant enzyme T163S, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.074
thymidine
-
mutant enzyme S182A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.263
thymidine
P03176
mutant enzyme P12N/H13I/Y127F, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.317
thymidine
mutant enzyme M28A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.336
thymidine
-
mutant enzyme L134A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.349
thymidine
mutant enzyme M28I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.565
thymidine
-
mutant enzyme M42I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.59
thymidine
P03176
mutant enzyme P12N/Y127F, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.612
thymidine
P03176
mutant enzyme H13I, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
6
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125D
0.072
TTP
-
recombinant wild-type enzyme, pH 7.5, 37°C
0.127
TTP
-
recombinant mutant T298S, pH 7.5, 37°C
1.462
uridine
pH 7.4, 25°C
7.8
uridine
-
full-length enzyme, at pH 7.8 and 37°C
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
Tequatrovirus T4
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
additional information
additional information
-
-
-
additional information
additional information
kinetics
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
kinetics of wild-type and mutant enzymes in absence or presence of ATP, overview
-
additional information
additional information
-
kinetics, ATP-binding kinetics of wild-type and mutant enzymes at room temperature
-
additional information
additional information
-
steady-state kinetics, kinetics of conformational changes induced by ligand binding
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0253
(E)-5-(2-bromovinyl)-2'-deoxyuridine
Herpes simplex virus
-
determined by capillary electrophoresis method
0.03
2',3'-didehydro-2',3'-dideoxythymidine
-
at pH 7.8 and 25°C
0.41
2',3'-dideoxy-2',3'-didehydrothymidine
37°C, pH not specified in the publication
0.29 - 1.6
2',3'-dideoxy-3'-azidothymidine
0.33
2',3'-dideoxythymidine
37°C, pH not specified in the publication
0.2 - 262
2'-deoxythymidine
0.7 - 3.06
2'-deoxyuridine
0.5
2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil
37°C, pH not specified in the publication
0.17
3'-azido-2',3'-dideoxythymidine
-
at pH 7.8 and 25°C
0.009 - 412
3'-azido-3'-deoxythymidine
0.47
3-[1(2)-closo-1,7-carboranylbutyltetrazol-5-ylmethyl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.32
3-[1(2)-closo-1,7-carboranylbutyltetrazol-5-yl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.44
3-[1(2)-closo-1,7-carboranylethyltetrazol-5-ylmethyl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.35
3-[1(2)-closo-1,7-carboranylethyltetrazol-5-yl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.39
3-[1(2)-closo-1,7-carboranylpropyltetrazol-5-ylmethyl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.37
3-[1(2)-closo-1,7-carboranylpropyltetrazol-5-yl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.45
3-[1(2)-propyltetrazol-5-ylmethyl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.34
3-[1(2)-propyltetrazol-5-yl]thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
3.47
5-bromo-2'-deoxyuridine
pH 7.4, 25°C
0.24 - 4.66
5-fluoro-2'-deoxyuridine
3.6
5-fluorodeoxyuridine
-
full-length enzyme, at pH 7.8 and 37°C
2.82
5-hydroxymethyl-2'-deoxyuridine
pH 7.4, 25°C
0.238
aciclovir monophosphate
Herpes simplex virus
-
determined by capillary electrophoresis method
0.000283 - 0.015
acyclovir
0.007
beta-L-thymidine
-
at pH 7.8 and 25°C
0.047
deoxyadenosine
-
full-length enzyme, at pH 7.8 and 37°C
0.34
deoxyguanosine
-
full-length enzyme, at pH 7.8 and 37°C
0.8
deoxyinosine
-
full-length enzyme, at pH 7.8 and 37°C
0.29
dioxolane thymidine
37°C, pH not specified in the publication
0.0035 - 0.47
ganciclovir
0.0272
ganciclovir monophosphate
Herpes simplex virus
-
determined by capillary electrophoresis method
0.36
trifluoromethylthymidine
-
at pH 7.8 and 25°C
additional information
2'-deoxythymidine
0.29
2',3'-dideoxy-3'-azidothymidine
37°C, pH not specified in the publication
1.6
2',3'-dideoxy-3'-azidothymidine
82°C, pH not specified in the publication
0.2
2'-deoxythymidine
-
pH 8.0, 37°C
6.47
2'-deoxythymidine
-
37°C, pH 7.6
23
2'-deoxythymidine
-
37°C, pH 7.6
220
2'-deoxythymidine
-
37°C, pH 7.6
262
2'-deoxythymidine
pH 7.4, 25°C
0.7
2'-deoxyuridine
37°C, pH not specified in the publication
3.06
2'-deoxyuridine
pH 7.4, 25°C
0.009
3'-azido-3'-deoxythymidine
Q8LDP6, Q9FN47
isoform TK1b, pH and temperature not specified in the publication
0.13
3'-azido-3'-deoxythymidine
Q8LDP6, Q9FN47
isoform TK1a, pH and temperature not specified in the publication
0.24
3'-azido-3'-deoxythymidine
mutant enzyme M28I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.34
3'-azido-3'-deoxythymidine
mutant enzyme M28A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.53
3'-azido-3'-deoxythymidine
-
37°C, pH 7.6
0.58
3'-azido-3'-deoxythymidine
-
mutant enzyme S182A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.81
3'-azido-3'-deoxythymidine
-
mutant enzyme M42I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.97
3'-azido-3'-deoxythymidine
-
37°C, pH 7.6
1.3
3'-azido-3'-deoxythymidine
mutant enzyme T163S, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
1.4
3'-azido-3'-deoxythymidine
mutant enzyme L124A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
1.5
3'-azido-3'-deoxythymidine
-
mutant enzyme S182T, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
1.97
3'-azido-3'-deoxythymidine
pH 7.4, 25°C
3.5
3'-azido-3'-deoxythymidine
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
9.3
3'-azido-3'-deoxythymidine
-
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
412
3'-azido-3'-deoxythymidine
-
37°C, pH 7.6
0.24
5-fluoro-2'-deoxyuridine
-
at pH 7.8 and 25°C
0.74
5-fluoro-2'-deoxyuridine
37°C, pH not specified in the publication
4.66
5-fluoro-2'-deoxyuridine
pH 7.4, 25°C
0.000283
acyclovir
Herpes simplex virus
-
37°C, mutant SR26
0.000433
acyclovir
Herpes simplex virus
-
37°C, mutant SR39
0.000467
acyclovir
Herpes simplex virus
-
37°C, mutant SR11
0.015
acyclovir
Herpes simplex virus
-
37°C, wild-type
0.28
ATP
-
at pH 7.8 and 25°C
0.4
ATP
37°C, pH not specified in the publication
2 - 8
ATP
-
recombinant wild-type enzyme, pH 7.5, 37°C
3.1
ATP
-
full-length enzyme, with 0.05 mM thymidine as cosubstrate, at pH 7.8 and 37°C
3.5
ATP
82°C, pH not specified in the publication
3.9
ATP
-
thymidine kinase domain 2, with 0.05 mM thymidine as cosubstrate, at pH 7.8 and 37°C
7
ATP
-
recombinant mutant K297R, pH 7.5, 37°C
11
ATP
-
recombinant mutant G294A, pH 7.5, 37°C
24
ATP
-
recombinant mutant T298S, pH 7.5, 37°C
9
CTP
-
recombinant mutant G294A, pH 7.5, 37°C
13.5
CTP
-
about, recombinant mutant T298S, pH 7.5, 37°C
14
CTP
-
recombinant mutant K297R, pH 7.5, 37°C
19
CTP
-
recombinant wild-type enzyme, pH 7.5, 37°C
0.17
deoxycytidine
-
mutant enzyme M42I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
1.4
deoxycytidine
Herpes simplex virus
-
pH 7.6
0.045
deoxyuridine
Q8LDP6, Q9FN47
isoform TK1b, pH and temperature not specified in the publication
0.53
deoxyuridine
-
at pH 7.8 and 25°C
1.3
deoxyuridine
Herpes simplex virus
-
pH 7.6
1.5
deoxyuridine
Q8LDP6, Q9FN47
isoform TK1a, pH and temperature not specified in the publication
5.1
deoxyuridine
-
full-length enzyme, at pH 7.8 and 37°C
5.3
deoxyuridine
-
thymidine kinase domain 2, at pH 7.8 and 37°C
0.0035
ganciclovir
Herpes simplex virus
-
37°C, mutant SR39
0.0056
ganciclovir
Herpes simplex virus
-
37°C, mutant SR11
0.0089
ganciclovir
Herpes simplex virus
-
37°C, mutant SR26
0.04
ganciclovir
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125N
0.08
ganciclovir
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125E
0.1
ganciclovir
Herpes simplex virus
-
37°C, wild-type
0.47
ganciclovir
Herpes simplex virus
-
pH 7.6, 37°C, wild-type
8
GTP
-
recombinant mutant G294A, pH 7.5, 37°C
17
GTP
-
recombinant mutant T298S, pH 7.5, 37°C
18.5
GTP
-
about, recombinant mutant K297R, pH 7.5, 37°C
21
GTP
-
recombinant wild-type enzyme, pH 7.5, 37°C
0.003
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125N
0.0062
thymidine
Herpes simplex virus
-
37°C, mutant SR26
0.007
thymidine
Herpes simplex virus
-
37°C, mutant SR11
0.017
thymidine
Herpes simplex virus
-
37°C, mutant SR39
0.02
thymidine
Q8LDP6, Q9FN47
isoform TK1b, pH and temperature not specified in the publication
0.06
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, wild-type
0.11
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125D
0.13
thymidine
Herpes simplex virus
-
pH 7.6, 37°C, mutant Q125E
0.28
thymidine
-
at pH 7.8 and 25°C
0.3
thymidine
37°C, pH not specified in the publication
0.46
thymidine
Herpes simplex virus
-
37°C, wild-type
0.46
thymidine
-
in 25 mM Tris-HCl (pH 7.6), 5 mM MgCl2, 125 mM KCl, 10 mM dithiothreitol, and 0.5 mg/ml bovine serum albumin, at 37°C
0.48
thymidine
Q8LDP6, Q9FN47
isoform TK1a, pH and temperature not specified in the publication
0.74
thymidine
-
mutant enzyme S182A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.97
thymidine
-
mutant enzyme S182T, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
1.4
thymidine
mutant enzyme M28A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
1.5
thymidine
mutant enzyme M28I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
1.8
thymidine
mutant enzyme L124A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
2.7
thymidine
mutant enzyme T163S, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
2.8
thymidine
-
mutant enzyme M42I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
3.1
thymidine
-
full-length enzyme, at pH 7.8 and 37°C
3.5
thymidine
-
thymidine kinase domain 2, at pH 7.8 and 37°C
3.5
thymidine
82°C, pH not specified in the publication
4.9
thymidine
-
mutant enzyme L134A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
6.4
thymidine
-
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
9.5
thymidine
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
265.5
thymidine
-
pH 8.0, 37°C, recombinant mutant S13D
282
thymidine
-
pH 8.0, 37°C, recombinant wild-type enzyme
7
TTP
-
recombinant mutant T298S, pH 7.5, 37°C
11
TTP
-
recombinant wild-type enzyme, pH 7.5, 37°C
0.44
uridine
pH 7.4, 25°C
1.5
uridine
-
full-length enzyme, at pH 7.8 and 37°C
additional information
2'-deoxythymidine
-
37°C, pH 7.6
additional information
additional information
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.064
2',3'-didehydro-2',3'-dideoxythymidine
-
at pH 7.8 and 25°C
5.4
2',3'-dideoxy-2',3'-didehydrothymidine
37°C, pH not specified in the publication
180 - 450
2',3'-dideoxy-3'-azidothymidine
11
2',3'-dideoxythymidine
37°C, pH not specified in the publication
2380
2'-deoxythymidine
pH 7.4, 25°C
276 - 480
2'-deoxyuridine
3.8
2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil
37°C, pH not specified in the publication
5
3'-azido-2',3'-dideoxythymidine
-
at pH 7.8 and 25°C
0.0031 - 651
3'-azido-3'-deoxythymidine
1690
5-bromo-2'-deoxyuridine
pH 7.4, 25°C
5.8 - 814
5-fluoro-2'-deoxyuridine
120
5-fluorodeoxyuridine
-
full-length enzyme, at pH 7.8 and 37°C
29.1
5-hydroxymethyl-2'-deoxyuridine
pH 7.4, 25°C
0.0024
beta-L-thymidine
-
at pH 7.8 and 25°C
0.0056
deoxyadenosine
-
full-length enzyme, at pH 7.8 and 37°C
0.0019 - 0.048
deoxycytidine
0.0066 - 0.23
deoxyguanosine
0.32
deoxyinosine
-
full-length enzyme, at pH 7.8 and 37°C
2.5
dioxolane thymidine
37°C, pH not specified in the publication
6.4
trifluoromethylthymidine
-
at pH 7.8 and 25°C
180
2',3'-dideoxy-3'-azidothymidine
82°C, pH not specified in the publication
450
2',3'-dideoxy-3'-azidothymidine
37°C, pH not specified in the publication
276
2'-deoxyuridine
pH 7.4, 25°C
480
2'-deoxyuridine
37°C, pH not specified in the publication
0.0031
3'-azido-3'-deoxythymidine
mutant enzyme T163S, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.0067
3'-azido-3'-deoxythymidine
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.078
3'-azido-3'-deoxythymidine
-
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.35
3'-azido-3'-deoxythymidine
-
mutant enzyme M42I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.44
3'-azido-3'-deoxythymidine
mutant enzyme L124A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.49
3'-azido-3'-deoxythymidine
-
mutant enzyme L134A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.94
3'-azido-3'-deoxythymidine
mutant enzyme M28I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
1.4
3'-azido-3'-deoxythymidine
-
mutant enzyme S182A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
1.7
3'-azido-3'-deoxythymidine
mutant enzyme M28A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
22
3'-azido-3'-deoxythymidine
Q8LDP6, Q9FN47
isoform TK1b, pH and temperature not specified in the publication
48
3'-azido-3'-deoxythymidine
Q8LDP6, Q9FN47
isoform TK1a, pH and temperature not specified in the publication
98
3'-azido-3'-deoxythymidine
-
mutant enzyme S182T, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
651
3'-azido-3'-deoxythymidine
pH 7.4, 25°C
5.8
5-fluoro-2'-deoxyuridine
-
at pH 7.8 and 25°C
740
5-fluoro-2'-deoxyuridine
37°C, pH not specified in the publication
814
5-fluoro-2'-deoxyuridine
pH 7.4, 25°C
2.3
ATP
-
at pH 7.8 and 25°C
10
ATP
37°C, pH not specified in the publication
15
ATP
-
full-length enzyme, with 0.05 mM thymidine as cosubstrate, at pH 7.8 and 37°C
18
ATP
82°C, pH not specified in the publication
40
ATP
-
thymidine kinase domain 2, with 0.05 mM thymidine as cosubstrate, at pH 7.8 and 37°C
0.0019
deoxycytidine
-
mutant enzyme L134A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.048
deoxycytidine
-
mutant enzyme M42I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.0066
deoxyguanosine
-
mutant enzyme S182A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.13
deoxyguanosine
-
full-length enzyme, at pH 7.8 and 37°C
0.23
deoxyguanosine
-
mutant enzyme S182T, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
4.5
deoxyuridine
-
at pH 7.8 and 25°C
6.8
deoxyuridine
Q8LDP6, Q9FN47
isoform TK1b, pH and temperature not specified in the publication
12
deoxyuridine
-
thymidine kinase domain 2, at pH 7.8 and 37°C
63
deoxyuridine
-
full-length enzyme, at pH 7.8 and 37°C
150
deoxyuridine
Q8LDP6, Q9FN47
isoform TK1a, pH and temperature not specified in the publication
0.0028
thymidine
-
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.0068
thymidine
wild type enzyme, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.46
thymidine
mutant enzyme T163S, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
0.51
thymidine
mutant enzyme L124A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
4.2
thymidine
mutant enzyme M28I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
4.5
thymidine
mutant enzyme M28A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
4.8
thymidine
-
at pH 7.8 and 25°C
5
thymidine
-
mutant enzyme M42I, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
10
thymidine
-
mutant enzyme S182A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
14
thymidine
Q8LDP6, Q9FN47
isoform TK1b, pH and temperature not specified in the publication
15
thymidine
-
mutant enzyme L134A, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
76
thymidine
-
thymidine kinase domain 2, at pH 7.8 and 37°C
400
thymidine
-
full-length enzyme, at pH 7.8 and 37°C
600
thymidine
37°C, pH not specified in the publication
750
thymidine
-
mutant enzyme S182T, in 50 mM Tris-HCl, pH 7.5, 10 mM dithiothreitol, 2.5 mM MgCl2, 0.5 mM CHAPS, 3 mM NaF, 0.5 mg/ml bovine serum albumin and 2.5 mM ATP, temperature not specified in the publication
770
thymidine
Q8LDP6, Q9FN47
isoform TK1a, pH and temperature not specified in the publication
3500
thymidine
82°C, pH not specified in the publication
0.03
uridine
pH 7.4, 25°C
0.19
uridine
-
full-length enzyme, at pH 7.8 and 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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0.028 - 0.5
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate
0.03 - 0.5
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate
0.0046 - 0.281
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate
0.019 - 0.5
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate
0.011 - 0.42
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate
0.04 - 0.5
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate
0.265 - 0.5
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
0.371 - 0.5
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
0.043
(E)-5-(2-bromovinyl)-1-beta-D-(arabinofuranosyl)uracil
Homo sapiens
-
-
0.5
1-(3'-deoxy-5'-O-triphenylmethyl-beta-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)-phenyl)-thiourea
Homo sapiens
-
IC50 above 0.5 mM, thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.041 - 0.365
1-(3,4-dichlorobenzyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
0.057 - 0.422
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
0.099 - 0.5
1-benzyl-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
0.285
1-beta-D-(arabinofuranosyl)thymine
Homo sapiens
-
-
0.18
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.057
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.022 - 0.5
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.0035 - 0.5
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.01 - 0.5
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine
0.173 - 0.224
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.0015
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.013 - 0.017
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.0012 - 0.0036
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.00015 - 0.195
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]thiourea
0.00042 - 0.335
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]urea
0.038 - 0.472
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
0.405 - 0.5
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea
0.023 - 0.198
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
0.0041 - 0.119
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
0.0047
3'-(1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.06 - 0.12
3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
0.053 - 0.211
3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine
0.105 - 0.208
3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine
0.044 - 0.071
3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
0.0003
3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.073 - 0.078
3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
0.00023
3'-(4-butyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0033
3'-(4-chlorobenzylamino)-3'-deoxy-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.000036
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.000046
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.00015
3'-(4-cyclopentylmethyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.086 - 0.15
3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
0.099 - 0.2
3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
0.189 - 0.311
3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
0.114 - 0.318
3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
0.004
3'-(5-(4-chlorophenyl)-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0012 - 0.4
3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine
0.000036 - 0.00015
3'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',3'-dideoxy-3,4-dihydrothymidine
0.003 - 0.0125
3'-azido-3'-deoxythymidine
0.0046
3'-benzylamino-3'-deoxy-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.000042
3'-deoxy-3'-(4-(3,4-dichlorophenyl)-1,2,3-triazol-1-yl)-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.00025
3'-deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.00032
3'-deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0013
3'-deoxy-3'-(4-pyridin-2-yl-1,2,3-triazol-1-yl)-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.0011
3'-deoxy-3'-(5-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.00064 - 0.087
3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine
0.0031 - 0.5
3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine
0.0012 - 0.444
3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine
0.018
3'-ethyl-5-methyl-2'-deoxyuridine
Entamoeba histolytica
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.0046
3'-spiro-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)-5-methyluridine
Homo sapiens
inhibits phosphorylation of 2'-deoxythymidine, IC50: 0.0046 mM
0.00033
3'-[(3-trifluoromethyl-4-chloro)-benzylamino]-3'-deoxy-beta-D-thymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.00043 - 0.232
3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
0.00047 - 0.046
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
0.175 - 0.44
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide
0.191 - 0.194
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide
0.031 - 0.392
5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine
0.11 - 0.5
5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine
0.468
5'-O-(4,4'-dimethoxytrityl)thymidine
Homo sapiens
IC50: 0.468 mM
0.000014
5-(3'-amino-3'-deoxy-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'Nyl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.000035
5-(3'-amino-3'-deoxy-beta-D-thymidin-3'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.0009
5-(3'-amino-3'-deoxy-beta-D-thymidin-3'N-yl)-1-benzyl-tetrazole
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.0013 - 0.5
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.0026
5-benzylamino-(3'-deoxy-beta-D-thymidin-3'N-yl)-tetrazole
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.02 - 0.5
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.0046 - 0.048
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
0.001
5-iodo-2'-deoxyuridine
Entamoeba histolytica
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.003 - 0.025
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.491
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.0023 - 0.5
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.484 - 0.5
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine
0.0015 - 0.1
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
0.0031 - 0.404
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione
0.0033 - 0.01
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione
0.0444
5-propyl-2'-deoxyuridine
Entamoeba histolytica
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.0006
5-trifluoromethyl-2-deoxyuridine
Entamoeba histolytica
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.00059
5-[(4-chloro-3-trifluoromethylphenyl)amino]-1-(3'-deoxy-beta-D-thymidin-3'N-yl)-tetrazole
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.0012
5-[(E)-2-bromoethenyl]-2'-O-decanoyluridine
Homo sapiens
competitive with respect to 2'-deoxythymidine, IC50: 0.0012 mM
0.00015 - 0.006
5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine
0.0004
5-[amino-(4-chloro-3-trifluoromethylphenyl)]-1-(3'-deoxy-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridin-3'N-yl)-tetrazole
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.0034 - 0.019
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide
0.015
6-methyluridine
Entamoeba histolytica
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.5
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine
0.017
alpha-D-5-ethyl-2'-deoxyuridine
Entamoeba histolytica
-
0.035
alpha-L-thymidine
Entamoeba histolytica
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.0025
beta-D-5-ethyl-2'-deoxyuridine
Entamoeba histolytica
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.005
beta-L-thymidine
Entamoeba histolytica
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.0038
dTTP
Leishmania major
Hill coefficient 1.6, pH 7.4, 37°C
0.187
dUTP
Leishmania major
pH 7.4, 37°C
0.46 - 0.5
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.353 - 0.5
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.318 - 0.5
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.0013
N-(3'-deoxy-beta-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-benzylguanidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.00043
N-(3'-deoxy-beta-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-guanidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.00058
N-(3'-deoxy-beta-D-thymidin-3'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)-isopropylguanidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.268 - 0.5
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.238 - 0.5
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.038 - 0.043
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.000046
N-methyl-4-[[[8-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)octyl]oxy](diphenyl)methyl]benzamide
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.027 - 0.115
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide
0.028 - 0.072
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide
0.033 - 0.131
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide
0.287 - 0.5
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.208 - 0.495
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
0.075 - 0.275
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
0.5
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine
0.0011
P1-(5'-adenosyl)-P5-(5'-thymidyl)pentaphosphate
Leishmania major
pH 7.4, 37°C
0.01
penciclovir
Entamoeba histolytica
at 37°C for 20 min in 30 mM potassium phosphate, pH 8.0, 1.2 mM MgCl2
0.028
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate
Homo sapiens
IC50: 0.028 mM
0.5
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.03
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate
Homo sapiens
IC50: 0.03 mM
0.5
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.0046
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate
Homo sapiens
IC50: 0.0046 mM
0.281
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate
Human alphaherpesvirus 1
-
IC50: 0.281 mM
0.019
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate
Homo sapiens
IC50: 0.019 mM
0.5
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.011
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate
Homo sapiens
IC50: 0.011 mM
0.42
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate
Human alphaherpesvirus 1
-
IC50: 0.42 mM
0.04
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate
Homo sapiens
IC50: 0.04 mM
0.5
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.265
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
Homo sapiens
IC50: 0.265 mM
0.5
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.371
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
Homo sapiens
IC50: 0.371 mM
0.5
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.041
1-(3,4-dichlorobenzyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
Homo sapiens
-
-
0.365
1-(3,4-dichlorobenzyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
Human alphaherpesvirus 1
P03176
-
0.057
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
Homo sapiens
-
-
0.422
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
Human alphaherpesvirus 1
P03176
-
0.099
1-benzyl-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
Homo sapiens
-
-
0.5
1-benzyl-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
Human alphaherpesvirus 1
P03176
IC50 above 0.5 mM
0.18
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.18 mM
0.18
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.18 mM
0.057
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.057 mM
0.057
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.057 mM
0.022
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.022 mM
0.5
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.0035
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.0035 mM
0.0035
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.0035 mM
0.5
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: above 0.5 mM
0.01
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine
Homo sapiens
IC50: 0.01 mM
0.5
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.173
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.173 mM
0.224
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.224 mM
0.013
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.013 mM
0.017
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.017 mM
0.0012
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.0012 mM
0.0036
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.0036 mM
0.00015
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]thiourea
Homo sapiens
-
-
0.195
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]thiourea
Human alphaherpesvirus 1
P03176
-
0.00042
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]urea
Homo sapiens
-
-
0.335
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[(2S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]urea
Human alphaherpesvirus 1
P03176
-
0.038
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
Homo sapiens
-
-
0.472
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
Human alphaherpesvirus 1
P03176
-
0.405
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea
Homo sapiens
-
-
0.5
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea
Human alphaherpesvirus 1
P03176
IC50 above 0.5 mM
0.023
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
Homo sapiens
IC50: 0.023 mM
0.198
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
Human alphaherpesvirus 1
-
IC50: 0.198 mM
0.0041
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
Homo sapiens
IC50: 0.0041 mM
0.119
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide
Human alphaherpesvirus 1
-
IC50: 0.119 mM
0.06
3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.12
3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.053
3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.211
3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.105
3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.208
3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.044
3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.071
3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.073
3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.078
3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.086
3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.15
3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.099
3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.2
3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.189
3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.311
3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.114
3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.318
3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.0012
3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine
Homo sapiens
-
-
0.4
3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine
Human alphaherpesvirus 1
P03176
-
0.000036
3'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',3'-dideoxy-3,4-dihydrothymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.00015
3'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',3'-dideoxy-3,4-dihydrothymidine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml bovine serum albumin, at 37°C
0.003
3'-azido-3'-deoxythymidine
Homo sapiens
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.0125
3'-azido-3'-deoxythymidine
Ureaplasma parvum
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C
0.00064
3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine
Homo sapiens
-
-
0.087
3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine
Human alphaherpesvirus 1
P03176
-
0.0031
3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine
Homo sapiens
-
-
0.5
3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine
Human alphaherpesvirus 1
P03176
IC50 above 0.5 mM
0.0012
3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine
Homo sapiens
-
-
0.444
3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine
Human alphaherpesvirus 1
P03176
-
0.00043
3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
Homo sapiens
-
-
0.232
3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
Human alphaherpesvirus 1
P03176
-
0.00047
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
Homo sapiens
-
-
0.046
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
Human alphaherpesvirus 1
P03176
-
0.175
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide
Human alphaherpesvirus 1
-
IC50: 0.175 mM
0.44
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide
Homo sapiens
IC50: 0.44 mM
0.191
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide
Human alphaherpesvirus 1
-
IC50: 0.191 mM
0.194
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide
Homo sapiens
IC50: 0.194 mM
0.031
5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine
Homo sapiens
-
-
0.392
5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine
Human alphaherpesvirus 1
P03176
-
0.11
5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine
Homo sapiens
-
-
0.5
5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine
Human alphaherpesvirus 1
P03176
IC50 above 0.5 mM
0.0013
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
Homo sapiens
IC50: 0.0013 mM
0.1
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
Homo sapiens
IC50: 0.1 mM
0.5
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.02
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
Homo sapiens
IC50: 0.02 mM
0.5
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.0046
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
Homo sapiens
IC50: 0.0046 mM
0.048
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil
Human alphaherpesvirus 1
-
IC50: 0.048 mM
0.003
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.003 mM
0.025
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.025 mM
0.491
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.491 mM
0.491
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.491 mM
0.0023
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.0023 mM
0.0023
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.0023 mM
0.5
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: above 0.5 mM
0.484
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine
Homo sapiens
IC50: 0.484 mM
0.5
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.0015
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.0015 mM
0.045
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.045 mM
0.1
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: above 0.1 mM
0.0031
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.0031 mM
0.404
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.404 mM
0.0033
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
IC50: 0.0033 mM
0.01
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione
Human alphaherpesvirus 1
-
IC50: 0.01 mM
0.00015
5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine
Homo sapiens
-
thymidine kinase 2, in 50 mM Tris/HCl, pH 8.0, 2.5 mM MgCl2, 10 mM dithiothreitol, 0.5 mM CHAPS, 3 mg/ml obvine serum albumin, at 37°C
0.006
5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine
Homo sapiens
IC50: 0.006 mM
0.0034
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide
Human alphaherpesvirus 1
-
IC50: 0.0034 mM
0.019
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide
Homo sapiens
IC50: 0.019 mM
0.5
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.5
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine
Homo sapiens
IC50: above 0.5 mM
0.46
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Homo sapiens
IC50: 0.46 mM
0.5
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.353
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
Homo sapiens
IC50: 0.353 mM
0.5
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.318
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Homo sapiens
IC50: 0.318 mM
0.5
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.268
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
Homo sapiens
IC50: 0.268 mM
0.5
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.238
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Homo sapiens
IC50: 0.238 mM
0.5
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.038
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
Homo sapiens
IC50: 0.038 mM
0.043
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
Human alphaherpesvirus 1
-
IC50: 0.043 mM
0.027
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide
Homo sapiens
IC50: 0.027 mM
0.115
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide
Human alphaherpesvirus 1
-
IC50: 0.115 mM
0.028
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide
Homo sapiens
IC50: 0.028 mM
0.072
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide
Human alphaherpesvirus 1
-
IC50: 0.072 mM
0.033
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide
Homo sapiens
IC50: 0.033 mM
0.131
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide
Human alphaherpesvirus 1
-
IC50: 0.131 mM
0.287
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Homo sapiens
IC50: 0.287 mM
0.5
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.208
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Homo sapiens
IC50: 0.208 mM
0.495
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide
Human alphaherpesvirus 1
-
IC50: 0.495 mM
0.075
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
Homo sapiens
IC50: 0.075 mM
0.275
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide
Human alphaherpesvirus 1
-
IC50: 0.275 mM
0.5
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine
Human alphaherpesvirus 1
-
IC50: above 0.5 mM
0.5
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine
Homo sapiens
IC50: above 0.5 mM
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