Information on EC 2.7.1.208 - protein-Npi-phosphohistidine-maltose phosphotransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.1.208
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RECOMMENDED NAME
GeneOntology No.
protein-Npi-phosphohistidine-maltose phosphotransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[protein]-Npi-phospho-L-histidine + maltose[side 1] = [protein]-L-histidine + maltose 6'-phosphate[side 2]
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Starch and sucrose metabolism
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SYSTEMATIC NAME
IUBMB Comments
protein-Npi-phospho-L-histidine:maltose Npi-phosphotransferase
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
[protein]-Npi-phospho-L-histidine + maltose[side 1]
[protein]-L-histidine + maltose 6'-phosphate[side 2]
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
[protein]-Npi-phospho-L-histidine + maltose[side 1]
[protein]-L-histidine + maltose 6'-phosphate[side 2]
show the reaction diagram
additional information
?
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
D-fructose
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a 40fold excess of unlabeled D-fructose reduces maltose uptake to about 30-40% of the control rate
D-galactose
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a 40fold excess of unlabeled galactose reduces maltose uptake to about 30-40% of the control rate
D-glucose
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a 40fold excess of unlabeled D-glucose reduces maltose uptake to about 60-70% of the control rate
D-mannose
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a 40fold excess of unlabeled D-mannose reduces mannose uptake to about 30-40% of the control rate
maltose
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a 40fold excess of unlabeled maltose reduces maltose uptake to 5% of the control rate
maltotetraose
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a 40fold excess of unlabeled maltotetraose reduces maltose uptake to about 60-70% of the control rate
maltotriose
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a 40fold excess of unlabeled maltotriose reduces maltose uptake to about 30-40% of the control rate
raffinose
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a 40fold excess of unlabeled raffinose reduces maltose uptake to about 60-70% of the control rate
Sucrose
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a 40fold excess of unlabeled sucrose reduces maltose uptake to about 60-70% of the control rate
additional information
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not inhibited by isomaltose
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
49977
x * 49977, calculated from amino acid sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE