Information on EC 2.7.1.204 - protein-Npi-phosphohistidine-D-galactose phosphotransferase

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The expected taxonomic range for this enzyme is: Streptococcus

EC NUMBER
COMMENTARY hide
2.7.1.204
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RECOMMENDED NAME
GeneOntology No.
protein-Npi-phosphohistidine-D-galactose phosphotransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[protein]-Npi-phospho-L-histidine + D-galactose[side 1] = [protein]-L-histidine + D-galactose 6-phosphate[side 2]
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
protein-Npi-phospho-L-histidine:D-galactose Npi-phosphotransferase
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
serotype C
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Manually annotated by BRENDA team
serotype C
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
[protein]-Npi-phospho-L-histidine + D-galactose[side 1]
[protein]-L-histidine + D-galactose 6-phosphate[side 2]
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
[protein]-Npi-phospho-L-histidine + D-galactose[side 1]
[protein]-L-histidine + D-galactose 6-phosphate[side 2]
show the reaction diagram
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
gene expression is markedly upregulated in cells growing on D-galactose
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