Information on EC 2.7.1.188 - 2-epi-5-epi-valiolone 7-kinase

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The expected taxonomic range for this enzyme is: Actinoplanes

EC NUMBER
COMMENTARY hide
2.7.1.188
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RECOMMENDED NAME
GeneOntology No.
2-epi-5-epi-valiolone 7-kinase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 2-epi-5-epi-valiolone = ADP + 2-epi-5-epi-valiolone 7-phosphate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Acarbose and validamycin biosynthesis
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
ATP:2-epi-5-epi-valiolone 7-phosphotransferase
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-epi-2-epi-5-epi-valiolol
?
show the reaction diagram
ATP + 2-epi-5-epi-valiolol
?
show the reaction diagram
ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 2-epi-5-epi-valiolone
ADP + 2-epi-5-epi-valiolone 7-phosphate
show the reaction diagram
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
His-tagged AcbM protein
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in strains of Streptomyces lividans 66 strains 1326, TK23, and TK64