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ATP + riboflavin
ADP + FMN
30% of the activity with CTP
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-
?
ATP + riboflavin
ADP + riboflavin 5'-phosphate
30% of the activity with ATP
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-
?
CTP + riboflavin
CDP + FMN
CTP + riboflavin
CDP + riboflavin 5'-phosphate
GTP + riboflavin
GDP + FMN
11% of the activity with CTP
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-
?
GTP + riboflavin
GDP + riboflavin 5'-phosphate
11% of the activity with ATP
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-
?
UTP + riboflavin
UDP + FMN
activity with UTP is at least one order of magnitude less efficient
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-
?
additional information
?
-
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
at reaction temperatures of up to 85°C (the temperature of the natural habitat of Methanocaldococcus jannaschii) riboflavin is completely converted to FMN
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?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + FMN
-
-
-
?
CTP + riboflavin
CDP + riboflavin 5'-phosphate
most active with CTP as the substrate
-
-
?
CTP + riboflavin
CDP + riboflavin 5'-phosphate
utilizes CTP rather than ATP as the donor nucleotide
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-
?
additional information
?
-
enzyme-DNA binding analysis using the recombinant enzyme, overview
-
-
-
additional information
?
-
enzyme-DNA binding analysis using the recombinant enzyme, overview
-
-
-
additional information
?
-
-
ATP and GTP do not support the production of FMN at 85°C
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-
?
additional information
?
-
ATP and GTP do not support the production of FMN at 85°C
-
-
?
additional information
?
-
enzyme-DNA binding analysis using the recombinant enzyme, overview. FMN-free pyRbkR protein binds two DNA fragments containing candidate regulatory sites upstream of the arfA and ribB genes in Pyrobaculum yellowstonensis. Both DNA fragments demonstrate specific interaction with pyRbkR, with apparent EC50 values in the range of 20-40 nM
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-
-
additional information
?
-
enzyme-DNA binding analysis using the recombinant enzyme, overview
-
-
-
additional information
?
-
-
enzyme-DNA binding analysis using the recombinant enzyme, overview
-
-
-
additional information
?
-
enzyme-DNA binding analysis using the recombinant enzyme, overview
-
-
-
additional information
?
-
enzyme-DNA binding analysis using the recombinant enzyme, overview
-
-
-
additional information
?
-
enzyme-DNA binding analysis using the recombinant enzyme, overview
-
-
-
additional information
?
-
enzyme-DNA binding analysis using the recombinant enzyme, overview
-
-
-
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evolution
prediction of RbkR operator sites and reconstruction of RbkR regulons in 94 archaeal genomes. While the identified RbkR operators show significant variability between archaeal lineages, the conserved core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake transporters and the rbkR gene. Genetic and sequence comparisons. RbkR regulators in Archaea represent a distinct class of metabolite-sensing transcription factors emerging via fusion between DNA-binding and catalytic domains
evolution
prediction of RbkR operator sites and reconstruction of RbkR regulons in 94 archaeal genomes. While the identified RbkR operators show significant variability between archaeal lineages, the conserved core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake transporters and the rbkR gene. Genetic and sequence comparisons. RbkR regulators in Archaea represent a distinct class of metabolite-sensing transcription factors emerging via fusion between DNA-binding and catalytic domains
evolution
prediction of RbkR operator sites and reconstruction of RbkR regulons in 94 archaeal genomes. While the identified RbkR operators show significant variability between archaeal lineages, the conserved core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake transporters and the rbkR gene. Genetic and sequence comparisons. RbkR regulators in Archaea represent a distinct class of metabolite-sensing transcription factors emerging via fusion between DNA-binding and catalytic domains
evolution
RbkRs genetic and sequence comparisons
evolution
-
RbkRs genetic and sequence comparisons
-
evolution
-
RbkRs genetic and sequence comparisons
-
evolution
-
RbkRs genetic and sequence comparisons
-
evolution
-
RbkRs genetic and sequence comparisons
-
evolution
-
prediction of RbkR operator sites and reconstruction of RbkR regulons in 94 archaeal genomes. While the identified RbkR operators show significant variability between archaeal lineages, the conserved core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake transporters and the rbkR gene. Genetic and sequence comparisons. RbkR regulators in Archaea represent a distinct class of metabolite-sensing transcription factors emerging via fusion between DNA-binding and catalytic domains
-
evolution
-
prediction of RbkR operator sites and reconstruction of RbkR regulons in 94 archaeal genomes. While the identified RbkR operators show significant variability between archaeal lineages, the conserved core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake transporters and the rbkR gene. Genetic and sequence comparisons. RbkR regulators in Archaea represent a distinct class of metabolite-sensing transcription factors emerging via fusion between DNA-binding and catalytic domains
-
evolution
-
prediction of RbkR operator sites and reconstruction of RbkR regulons in 94 archaeal genomes. While the identified RbkR operators show significant variability between archaeal lineages, the conserved core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake transporters and the rbkR gene. Genetic and sequence comparisons. RbkR regulators in Archaea represent a distinct class of metabolite-sensing transcription factors emerging via fusion between DNA-binding and catalytic domains
-
evolution
-
prediction of RbkR operator sites and reconstruction of RbkR regulons in 94 archaeal genomes. While the identified RbkR operators show significant variability between archaeal lineages, the conserved core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake transporters and the rbkR gene. Genetic and sequence comparisons. RbkR regulators in Archaea represent a distinct class of metabolite-sensing transcription factors emerging via fusion between DNA-binding and catalytic domains
-
evolution
-
prediction of RbkR operator sites and reconstruction of RbkR regulons in 94 archaeal genomes. While the identified RbkR operators show significant variability between archaeal lineages, the conserved core of RbkR regulons includes riboflavin biosynthesis genes, known/predicted vitamin uptake transporters and the rbkR gene. Genetic and sequence comparisons. RbkR regulators in Archaea represent a distinct class of metabolite-sensing transcription factors emerging via fusion between DNA-binding and catalytic domains
-
evolution
-
RbkRs genetic and sequence comparisons
-
metabolism
analysis of the mechanism of the RbkR-mediated transcriptional regulation of riboflavin metabolism in Archaea, overview
metabolism
analysis of the mechanism of the RbkR-mediated transcriptional regulation of riboflavin metabolism in Archaea, overview
metabolism
analysis of the mechanism of the RbkR-mediated transcriptional regulation of riboflavin metabolism in Archaea, overview
metabolism
-
analysis of the mechanism of the RbkR-mediated transcriptional regulation of riboflavin metabolism in Archaea, overview
-
metabolism
-
analysis of the mechanism of the RbkR-mediated transcriptional regulation of riboflavin metabolism in Archaea, overview
-
metabolism
-
analysis of the mechanism of the RbkR-mediated transcriptional regulation of riboflavin metabolism in Archaea, overview
-
metabolism
-
analysis of the mechanism of the RbkR-mediated transcriptional regulation of riboflavin metabolism in Archaea, overview
-
metabolism
-
analysis of the mechanism of the RbkR-mediated transcriptional regulation of riboflavin metabolism in Archaea, overview
-
physiological function
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain
physiological function
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain
physiological function
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain. The riboflavin kinase domain of RbkRs serves not only as an essential function in the flavin biosynthesis but also as a sensor domain ofDNA-binding transcription factor
physiological function
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain. The riboflavin kinase domain of RbkRs serves not only as an essential function in the flavin biosynthesis but also as a sensor domain ofDNA-binding transcription factor
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain
-
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain
-
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain
-
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain
-
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain. The riboflavin kinase domain of RbkRs serves not only as an essential function in the flavin biosynthesis but also as a sensor domain ofDNA-binding transcription factor
-
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain. The riboflavin kinase domain of RbkRs serves not only as an essential function in the flavin biosynthesis but also as a sensor domain ofDNA-binding transcription factor
-
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain. The riboflavin kinase domain of RbkRs serves not only as an essential function in the flavin biosynthesis but also as a sensor domain ofDNA-binding transcription factor
-
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain. The riboflavin kinase domain of RbkRs serves not only as an essential function in the flavin biosynthesis but also as a sensor domain ofDNA-binding transcription factor
-
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain. The riboflavin kinase domain of RbkRs serves not only as an essential function in the flavin biosynthesis but also as a sensor domain ofDNA-binding transcription factor
-
physiological function
-
riboflavin kinase is an essential enzyme required for synthesis of FMN cofactor from vitamin B2. The bifunctional riboflavin kinase/regulator (RbkR) controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain
-
additional information
the FMN binding site comprises residues Tyr115, Phe165, Pro185, Tyr190, and Glu195
additional information
-
the FMN binding site comprises residues Tyr115, Phe165, Pro185, Tyr190, and Glu195
additional information
-
the FMN binding site comprises residues Tyr115, Phe165, Pro185, Tyr190, and Glu195
-
additional information
-
the FMN binding site comprises residues Tyr115, Phe165, Pro185, Tyr190, and Glu195
-
additional information
-
the FMN binding site comprises residues Tyr115, Phe165, Pro185, Tyr190, and Glu195
-
additional information
-
the FMN binding site comprises residues Tyr115, Phe165, Pro185, Tyr190, and Glu195
-
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Mashhadi, Z.; Zhang, H.; Xu, H.; White, R.H.
Identification and characterization of an archaeon-specific riboflavin kinase
J. Bacteriol.
190
2615-2618
2008
Methanocaldococcus jannaschii (Q60365), Methanocaldococcus jannaschii
brenda
Ammelburg, M.; Hartmann, M.D.; Djuranovic, S.; Alva, V.; Koretke, K.K.; Martin, J.; Sauer, G.; Truffault, V.; Zeth, K.; Lupas, A.N.; Coles, M.
A CTP-dependent archaeal riboflavin kinase forms a bridge in the evolution of cradle-loop barrels
Structure
15
1577-1590
2007
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii (Q60365)
brenda
Segato, F.; Nozawa, S.R.; Rossi, A.; Martinez-Rossi, N.M.
Over-expression of genes coding for proline oxidase, riboflavin kinase, cytochrome c oxidase and an MFS transporter induced by acriflavin in Trichophyton rubrum
Med. Mycol.
46
135-139
2008
Trichophyton rubrum
brenda
Rodionova, I.A.; Vetting, M.W.; Li, X.; Almo, S.C.; Osterman, A.L.; Rodionov, D.A.
A novel bifunctional transcriptional regulator of riboflavin metabolism in Archaea
Nucleic Acids Res.
45
3785-3799
2017
Pyrobaculum sp. WP30 (A0A0K1E2F9), Metallosphaera yellowstonensis (H2C8H2), Methanocaldococcus jannaschii (Q60365), Thermoplasma acidophilum (Q9HJA6), Thermoplasma acidophilum, Methanocaldococcus jannaschii NBRC 100440 (Q60365), Methanocaldococcus jannaschii DSM 2661 (Q60365), Methanocaldococcus jannaschii ATCC 43067 (Q60365), Methanocaldococcus jannaschii JAL-1 (Q60365), Thermoplasma acidophilum JCM 9062 (Q9HJA6), Thermoplasma acidophilum AMRC-C165 (Q9HJA6), Metallosphaera yellowstonensis MK1 (H2C8H2), Thermoplasma acidophilum ATCC 25905 (Q9HJA6), Thermoplasma acidophilum NBRC 15155 (Q9HJA6), Methanocaldococcus jannaschii JCM 10045 (Q60365)
brenda