Information on EC 2.7.1.13 - dehydrogluconokinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.1.13
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RECOMMENDED NAME
GeneOntology No.
dehydrogluconokinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 2-dehydro-D-gluconate = ADP + 6-phospho-2-dehydro-D-gluconate
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
glucose degradation (oxidative)
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Metabolic pathways
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Microbial metabolism in diverse environments
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Pentose phosphate pathway
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SYSTEMATIC NAME
IUBMB Comments
ATP:2-dehydro-D-gluconate 6-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9030-56-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
H16, also known as Alcaligenes eutrophus, enzyme is induced during growth on 2-ketogluconate
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Manually annotated by BRENDA team
strain PAO1
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 2-dehydro-D-gluconate
ADP + 2-dehydro-6-phosphogluconate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 2-dehydro-D-gluconate
ADP + 2-dehydro-6-phosphogluconate
show the reaction diagram
-
part of the 2-ketogluconate utilization operon
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?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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absolutely required for activity
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
-
stimulates
glutathione
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stimulates
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.6
2-dehydro-D-gluconate
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pH 7.5, 37°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.6
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
32600
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x * 32600, deduced from nucleotide sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x + 32000, recombinant 2-keto-gluconokinase, SDS-PAGE; x * 32600, deduced from nucleotide sequence
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
activity is lost upon dialysis
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-14°C, 14 months, 40% loss of activity
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression of 2-ketogluconokinase gene kguK in Escherichia coli
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