Reference on EC 2.7.1.113 - deoxyguanosine kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Barker, J.; Lewis, R.A.
Deoxyguanosine kinase of neonatal mouse skin tissue
Biochim. Biophys. Acta
658
111-123
1981
Mus musculus
Gower, W.R.; Carr, M.C.; Ives, D.H.
Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol
J. Biol. Chem.
254
2180-2183
1979
Bos taurus
Park, I.; Ives, D.H.
Properties of a highly purified mitochondrial deoxyguanosine kinase
Arch. Biochem. Biophys.
266
51-60
1988
Bos taurus
Green, F.J.; Lewis, R.A.
Partial purification and characterization of deoxyguanosine kinase from pig skin
Biochem. J.
183
547-553
1979
Sus scrofa
Yamada, Y.; Goto, H.; Ogasawara, N.
Deoxyguanosine kinase from human placenta
Biochim. Biophys. Acta
709
265-272
1982
Homo sapiens
Park, I.; Ives, D.H.
Kinetic mechanism and end-product regulation of deoxyguanosine kinase from beef liver mitochondria
J. Biochem.
117
1058-1061
1995
Bos taurus
Sjoberg, A.H.; Wang, L.; Eriksson, S.
Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs
Mol. Pharmacol.
53
270-273
1998
Homo sapiens
Zhu, C.; Johansson, M.; Permert, J.; Karlsson, A.
Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines
J. Biol. Chem.
273
14707-14711
1998
Homo sapiens
Gaubert, G.; Gosselin, G.; Boudou, V.; Imbach, J.L.; Eriksson, S.; Maury, G.
Low enantioselectivities of human deoxycytidine kinase and human deoxyguanosine kinase with respect to 2'-deoxyadenosine, 2'-deoxyguanosine and their analogs
Biochimie
81
1041-1047
1999
Homo sapiens
Petrakis, T.G.; Ktistaki, E.; Wang, L.; Eriksson, S.; Talianidis, I.
Cloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoform
J. Biol. Chem.
274
24726-24730
1999
Mus musculus (Q9QX60), Mus musculus
Jullig, M.; Eriksson, S.
Mitochondrial and submitochondrial localization of human deoxyguanosine kinase
Eur. J. Biochem.
267
5466-5472
2000
Homo sapiens
Jullig, M.; Eriksson, S.
Apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase
J. Biol. Chem.
276
24000-24004
2001
Homo sapiens
Andersen, R.B.; Neuhard, J.
Deoxynucleoside kinases encoded by the yaaG and yaaF genes of Bacillus subtilis. Substrate specificity and kinetic analysis of deoxyguanosine kinase with UTP as the preferred phosphate donor
J. Biol. Chem.
276
5518-5524
2001
Bacillus subtilis
Herrstrom Sjoberg, A.; Wang, L.; Eriksson, S.
Antiviral guanosine analogs as substrates for deoxyguanosine kinase: implications for chemotherapy
Antimicrob. Agents Chemother.
45
739-742
2001
Bos taurus, Homo sapiens
Lotfi, K.; Mansson, E.; Peterson, C.; Eriksson, S.; Albertioni, F.
Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity
Biochem. Biophys. Res. Commun.
293
1489-1496
2002
Homo sapiens
Park, I.; Ives, D.H.
Mutations within the putative active site of heterodimeric deoxyguanosine kinase block the allosteric activation of the deoxyadenosine kinase subunit
J. Biochem. Mol. Biol.
35
244-247
2002
Lactobacillus johnsonii (Q74HC2), Lactobacillus johnsonii NCC 533 (Q74HC2)
Hong, Y.S.; Ma, G.T.; Ives, D.H.
Directed mutagenesis of deoxyguanosine site at arginine 79 up-regulates turnover on deoxyadenosine kinase subunit of heterodimeric enzyme from Lactobacillus acidophilus R26
J. Biol. Chem.
270
6602-6606
1995
Lactobacillus acidophilus
Ikeda, S.; Ma, G.T.; Ives, D.H.
Heterodimeric deoxynucleoside kinases of Lactobacillus acidophilus R-26: functional assignment of subunits using limited proteolysis controlled by end-product inhibitors
Biochemistry
33
5328-5334
1994
Lactobacillus acidophilus
Ma, G.T.; Hong, Y.S.; Ives, D.H.
Cloning and expression of the heterodimeric deoxyguanosine kinase/deoxyadenosine kinase of Lactobacillus acidophilus R-26
J. Biol. Chem.
270
6595-6601
1995
Lactobacillus johnsonii (Q74HC2), Lactobacillus johnsonii NCC 533 (Q74HC2)
Rodriguez, C.O., Jr.; Mitchell, B.S.; Ayres, M.; Eriksson, S.; Gandhi, V.
Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase
Cancer Res.
62
3100-3105
2002
Homo sapiens
Krawiec, K.; Kierdaszuk, B.; Shugar, D.
Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases
Biochem. Biophys. Res. Commun.
301
192-197
2003
Homo sapiens
Feng, J.Y.; Parker, W.B.; Krajewski, M.L.; Deville-Bonne, D.; Veron, M.; Krishnan, P.; Cheng, Y.C.; Borroto-Esoda, K.
Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases
Biochem. Pharmacol.
68
1879-1888
2004
Homo sapiens
Rylova, S.N.; Albertioni, F.; Flygh, G.; Eriksson, S.
Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs
Biochem. Pharmacol.
69
951-960
2005
Homo sapiens
Eriksson, S.; Munch-Petersen, B.; Johansson, K.; Eklund, H.
Structure and function of cellular deoxyribonucleoside kinases
Cell. Mol. Life Sci.
59
1327-1346
2002
Homo sapiens (Q16854)
Wang, L.; Eriksson, S.
Mitochondrial deoxyguanosine kinase mutations and mitochondrial DNA depletion syndrome
FEBS Lett.
554
319-322
2003
Homo sapiens
Piskur, J.; Sandrini, M.P.B.; Knecht, W.; Munch-Petersen, B.
Animal deoxyribonucleoside kinases: 'forward' and 'retrograde' evolution of their substrate specificity
FEBS Lett.
560
3-6
2004
Homo sapiens (Q16854)
Wang, L.; Limongelli, A.; Vila, M.R.; Carrara, F.; Zeviani, M.; Eriksson, S.
Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes
Mol. Genet. Metab.
84
75-82
2005
Homo sapiens
Johansson, K.; Ramaswamy, S.; Ljungcrantz, C.; Knecht, W.; Piskur, J.; Munch-Petersen, B.; Eriksson, S.; Eklund, H.
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
Nat. Struct. Biol.
8
616-620
2001
Homo sapiens (Q16854), Homo sapiens
Krawiec, K.; Kierdaszuk, B.; Kalinichenko, E.N.; Rubinova, E.B.; Mikhailopulo, I.A.; Eriksson, S.; Munch-Petersen, B.; Shugar, D.
Ability of adenosine-2'(3')-deoxy-3'(2')-triphosphates and related analogues to replace ATP as phosphate donor for all human and Drosphila melanogaster deoxyribonucleoside kinases
Nucleosides Nucleotides Nucleic Acids
22
1525-1529
2003
Homo sapiens
Al-Madhoun, A.S.; Eriksson, S.; Wang, Z.X.; Naimi, E.; Knaus, E.E.; Wiebe, L.I.
Phosphorylation of isocarbostyril- and difluorophenyl-nucleoside thymidine mimics by the human deoxynucleoside kinases
Nucleosides Nucleotides Nucleic Acids
23
1865-1874
2004
Homo sapiens
Van Rompay, A.R.; Johansson, M.; Karlsson, A.
Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
Pharmacol. Ther.
100
119-139
2003
Homo sapiens (Q16854)
Fyrberg, A.; Albertioni, F.; Lotfi, K.
Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes
Biochem. Biophys. Res. Commun.
357
847-853
2007
Homo sapiens
Mousson de Camaret, B.; Taanman, J.W.; Padet, S.; Chassagne, M.; Mayencon, M.; Clerc-Renaud, P.; Mandon, G.; Zabot, M.T.; Lachaux, A.; Bozon, D.
Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion
Biochem. J.
402
377-385
2007
Homo sapiens
Lotfi, K.; Karlsson, K.; Fyrberg, A.; Juliusson, G.; Jonsson, V.; Peterson, C.; Eriksson, S.; Albertioni, F.
The pattern of deoxycytidine- and deoxyguanosine kinase activity in relation to messenger RNA expression in blood cells from untreated patients with B-cell chronic lymphocytic leukemia
Biochem. Pharmacol.
71
882-890
2006
Homo sapiens
Franco, M.; Johansson, M.; Karlsson, A.
Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating HeLa cells
Exp. Cell Res.
313
2687-2694
2007
Homo sapiens
Sandrini, M.P.B.; Soederbom, F.; Mikkelsen, N.E.; Piskur, J.
Dictyostelium discoideum salvages purine deoxyribonucleosides by highly specific bacterial-like deoxyribonucleoside kinases
J. Mol. Biol.
369
653-664
2007
Dictyostelium discoideum (Q54UT2), Dictyostelium discoideum
Dimmock, D.P.; Zhang, Q.; Dionisi-Vici, C.; Carrozzo, R.; Shieh, J.; Tang, L.Y.; Truong, C.; Schmitt, E.; Sifry-Platt, M.; Lucioli, S.; Santorelli, F.M.; Ficicioglu, C.H.; Rodriguez, M.; Wierenga, K.; Enns, G.M.; Longo, N.; Lipson, M.H.; Vallance, H.; Craigen, W.J.; Scaglia, F.; Wong, L.J.
Clinical and molecular features of mitochondrial DNA depletion due to mutations in deoxyguanosine kinase
Hum. Mutat.
29
330-331
2008
Homo sapiens (Q16854), Homo sapiens
Dimmock, D.P.; Dunn, J.K.; Feigenbaum, A.; Rupar, A.; Horvath, R.; Freisinger, P.; Mousson de Camaret, B.; Wong, L.J.; Scaglia, F.
Abnormal neurological features predict poor survival and should preclude liver transplantation in patients with deoxyguanosine kinase deficiency
Liver Transpl.
14
1480-1485
2008
Homo sapiens
Saada, A.
Mitochondrial deoxyribonucleotide pools in deoxyguanosine kinase deficiency
Mol. Genet. Metab.
95
169-173
2008
Homo sapiens
Fyrberg, A.; Albertioni, F.; Lotfi, K.
RNAi depletion of deoxycytidine and deoxyguanosine kinase in human leukemic CEM cells
Nucleosides Nucleotides Nucleic Acids
27
712-719
2008
Homo sapiens
Pronicka, E.; Weglewska-Jurkiewicz, A.; Taybert, J.; Pronicki, M.; Szymanska-Debinska, T.; Karkucinska-Wieckowska, A.; Jakobkiewicz-Banecka, J.; Kowalski, P.; Piekutowska-Abramczuk, D.; Pajdowska, M.; Socha, P.; Sykut-Cegielska, J.; Wegrzyn, G.
Post mortem identification of deoxyguanosine kinase (DGUOK) gene mutations combined with impaired glucose homeostasis and iron overload features in four infants with severe progressive liver failure
J. Appl. Genet.
52
61-66
2011
Homo sapiens
Buchaklian, A.H.; Helbling, D.; Ware, S.M.; Dimmock, D.P.
Recessive deoxyguanosine kinase deficiency causes juvenile onset mitochondrial myopathy
Mol. Genet. Metab.
107
92-94
2012
Homo sapiens
Sun, R.; Eriksson, S.; Wang, L.
Zidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs
Antimicrob. Agents Chemother.
58
6758-6766
2014
Homo sapiens
Sun, R.; Eriksson, S.; Wang, L.
Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: implication for mitochondrial toxicities of anti-HIV nucleoside analogs
Biochem. Biophys. Res. Commun.
450
1021-1026
2014
Homo sapiens
Li, Y.; Ding, Q.; Ou, L.; Qian, Y.; Zhang, J.
One-pot process of 2-deoxyguanylic acid catalyzed by a multi-enzyme system
Biotechnol. Bioprocess Eng.
20
37-43
2015
Bacillus subtilis (P37530), Bacillus subtilis 168 (P37530)
-
Vilarinho, S.; Sari, S.; Yilmaz, G.; Stiegler, A.L.; Boggon, T.J.; Jain, D.; Akyol, G.; Dalgic, B.; Guenel, M.; Lifton, R.P.
Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension
Hepatology
63
1977-1986
2016
Homo sapiens (Q16854), Homo sapiens
Lin, S.; Huang, C.; Sun, J.; Bollt, O.; Wang, X.; Martine, E.; Kang, J.; Taylor, M.D.; Fang, B.; Singh, P.K.; Koomen, J.; Hao, J.; Yang, S.
The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma
EMBO Mol. Med.
11
e10849
2019
Homo sapiens (Q16854)
Mutahir, Z.; Christiansen, L.S.; Clausen, A.R.; Berchtold, M.W.; Gojkovic, Z.; Munch-Petersen, B.; Knecht, W.; Piskur, J.
Gene duplications and losses among vertebrate deoxyribonucleoside kinases of the non-TK1 family
Nucleosides Nucleotides Nucleic Acids
35
677-690
2016
no activity in Gallus gallus, Xenopus laevis (Q6GPW6)
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