Reference on EC 2.7.1.1 - hexokinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Misset, O.; Opperdoes, F.R.
Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei
Eur. J. Biochem.
144
475-483
1984
Trypanosoma brucei
Schmatz D.M.; Baginsky W.F.; Turner, M.J.
Evidence for and characterization of a mannitol cycle in Eimeria tenella
Mol. Biochem. Parasitol.
32
263-270
1989
Eimeria tenella
Tsai, C.S.; Chen, Q.
Purification and kinetic characterization of hexokinase and glucose-6-phosphate dehydrogenase from Schizosaccharomyces pombe
Biochem. Cell Biol.
76
107-113
1998
Schizosaccharomyces pombe, Schizosaccharomyces pombe NCYC 132S2-2
Fornaini, G.; Dacha, M.; Magnani, M.; Stocchi, V.
Hexokinase from rabbit red blood cells
Methods Enzymol.
90
3-10
1982
Oryctolagus cuniculus
-
Easterby, J.S.; Qadri, S.S.
Hexokinase type II from rat skeletal muscle
Methods Enzymol.
90
11-15
1982
Rattus norvegicus
-
Lee, C.Y.
Hexokinases from Drosophila melanogaster
Methods Enzymol.
90
16-21
1982
Drosophila melanogaster, Drosophila melanogaster Samarkand
-
Supowit, S.C.; Harris, B.G.
Hexokinase from Ascaris suum muscle
Methods Enzymol.
90
21-25
1982
Ascaris suum
-
Nakashima, R.A.; Paggi, M.G.; Scott, L.J.; Pedersen, P.L.
Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line
Cancer Res.
48
913-919
1988
Rattus norvegicus
Hashimoto, M.; Wilson, J.E.
Kinetic and regulatory properties of HK I+, a modified form of the type I isozyme of mammalian hexokinase in which interactions between the N- and C-terminal halves have been disrupted
Arch. Biochem. Biophys.
399
109-115
2002
Rattus norvegicus
Nwagwu, M.; Hirumi, H.
Trypanosoma (Nannomonas) congolense: properties of hexokinase and phosphofructokinase from cultured procyclic trypomastigotes and bloodstream forms
Acta Trop.
44
283-292
1987
Trypanosoma congolense
Serafini, G.; Magnani, M.; Stocchi, V.; Dacha, M.; Forniani, G.
Rat red blood cell hexokinase purification, properties and age-dependence
Mol. Cell. Biochem.
69
179-185
1986
Rattus norvegicus
Magnani, M.; Serafini, G.; Stocchi, V.; Dacha, M.; Fornaini, G.
Purification and properties of the cytoplasmic hexokinase from rabbit brain
Ital. J. Biochem.
33
392-402
1984
Oryctolagus cuniculus
Liu, S.S.; Witkovsky, P.; Yang, C.Y.
Retinal hexokinase: kinetic properties and the effect of cyclic 3,5-adenosine monophosphate
J. Neurochem.
41
1694-1701
1983
Lithobates catesbeianus
Racagni, G.E.; Machado de Domenech, E.E.
Characterization of Trypanosoma cruzi hexokinase
Mol. Biochem. Parasitol.
9
181-188
1983
Trypanosoma cruzi
Tahira, A.A.; Nakano, M.; Funayama, S.; Veiga, L.A.
Purification and properties of hexokinase from Trypanosoma cruzi
Arq. Biol. Tecnol. (Curitiba)
23
283-294
1980
Trypanosoma cruzi
-
Jacob, L.; Beecken, V.; Bartunik, L.J.
Purification and crystallization of yeast hexokinase isoenzymes. Characterization of different forms by chromatofocusing
J. Chromatogr.
587
85-92
1991
Saccharomyces cerevisiae
Liu, F.; Dong, Q.; Myers, A.M.; Fromm, H.J.
Expression of human brain hexokinase in Escherichia coli: Purification and characterization of the expressed enzyme
Biochem. Biophys. Res. Commun.
177
305-311
1991
Homo sapiens
Vandercammen, A.; Van Schaftingen, E.
Competitive inhibition of liver glucokinase by its regulatory protein
Eur. J. Biochem.
200
545-551
1991
Bos taurus, Rattus norvegicus, Rhinella marina, Sus scrofa
Nemat-Gorgani, M.; Wilson, J.E.
Acidic phospholipids may inhibit rat brain hexokinase by interaction at the nucleotide binding site
Arch. Biochem. Biophys.
236
220-227
1985
Rattus norvegicus
Herrero, R.F.P.; Moreno, F.
Inhibition and inactivation of glucose-phosphorylating enzymes from Saccharomyces cerevisiae by D-xylose
J. Gen. Microbiol.
131
2705-2709
1985
Saccharomyces cerevisiae, Saccharomyces cerevisiae G-517 / CECT 1317
Haritos, A.A.; Rosemeyer, M.A.
Purification and physical properties of hexokinase from human erythrocytes
Biochim. Biophys. Acta
873
335-339
1986
Homo sapiens
Machado de Domenech, E.E.; Sols, A.
Specificity of hexokinases towards some uncommon substrates and inhibitors
FEBS Lett.
119
174-176
1980
Bos taurus, Saccharomyces cerevisiae
Siebenlist, K.R.; Taketa, F.
Inhibition of red cell and yeast hexokinase by triethyltin bromide [(C2H5)3SnBr]
Biochem. Biophys. Res. Commun.
95
758-764
1980
Saccharomyces cerevisiae, Homo sapiens
Moser, D.; Johnson, L.; Lee, C.Y.
Multiple forms of Drosophila hexokinase. Purification, biochemical and immunological characterization
J. Biol. Chem.
255
4673-4679
1980
Drosophila melanogaster, Drosophila melanogaster Samarkand
Haritos, A.A.; Rosemeyer, M.A.
The purification and properties of human hexokinase
Biochem. Soc. Trans.
9
245
1981
Homo sapiens
-
Stocchi, V.; Magnani, M.; Canestrari, F.; Dacha, M.; Fornaini, G.
Rabbit red blood cell hexokinase. Evidence for two distinct forms, and their purification and characterization from reticulocytes
J. Biol. Chem.
256
7856-7862
1981
Oryctolagus cuniculus
Kalab, P.; Visconti, P.; Leclerc, P.; Kopf, G.S.
p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties
J. Biol. Chem.
269
3810-3817
1994
Mus musculus
Stocchi, V.; Magnani, M.; Canestrari, F.; Dacha, M.; Fornaini, G.
Multiple forms of human red blood cell hexokinase. Preparation, characterization, and age dependence
J. Biol. Chem.
257
2357-2364
1982
Homo sapiens
Kopetzki, E.; Entian, K.D.
Purification of yeast hexokinase isoenzymes using affinity chromatography and chromatofocusing
Anal. Biochem.
121
181-185
1982
Saccharomyces cerevisiae
Rber, B.; Stolle, J.; Reuter, G.
Eigenschaften der Hexokinase aus der SCP Hefe Candida maltosa H
Z. Allg. Mikrobiol.
24
619-627
1984
Candida maltosa
-
Radojkovic, J.; Ureta, T.
Hexokinase isoenzymes from the Novikoff hepatoma. Purification, kinetic and structural characterization, with emphasis on hexokinase C
Biochem. J.
242
895-903
1987
Rattus norvegicus
Yamashita, Y.; Ashihara, H.
Characterization of hexokinase and fructokinase from suspension-cultured Catharanthus roseus cells
Z. Naturforsch. C
43
827-834
1988
Catharanthus roseus, Catharanthus roseus B/TH
-
Kopetzki, E.; Entian, K.D.
Glucose repression and hexokinase isoenzymes in yeast. Isolation and characterization of a modified hexokinase PII isoenzyme
Eur. J. Biochem.
146
657-662
1985
Saccharomyces cerevisiae
White, T.K.; Wilson, J.E.
Isolation and characterization of the discrete N- and C-terminal halves of rat brain hexokinase: retention of full catalytic activity in the isolated C-terminal half
Arch. Biochem. Biophys.
274
375-393
1989
Rattus norvegicus
Magnani, M.; Stocchi, V.; Serafini, G.; Chiarantini, L.; Fornaini, G.
Purification, properties, and evidence for two subtypes of human placenta hexokinase type I
Arch. Biochem. Biophys.
260
388-399
1988
Homo sapiens
Renz, A.; Merlo, L.; Stitt, M.
Partial purification from potato tubers of three fructokinases and three hexokinases which show differing organ and developmental specificity
Planta
190
156-165
1993
Solanum tuberosum
-
Renz, A.; Stitt, M.
Substrate specificity and product inhibition of different forms of fructokinases and hexokinases in developing potato tubers
Planta
190
166-175
1993
Solanum tuberosum
-
Stocchi, V.; Magnani, M.; Novelli, G.; Dacha, M.; Fornaini, G.
Pig red blood cell hexokinase: Evidence for the presence of hexokinase types II and III, and their purification and characterization
Arch. Biochem. Biophys.
226
365-376
1983
Sus scrofa
Magnani, M.; Stocchi, V.; Serafini, N.; Piatti, E.; Dacha, M.; Fornaini, G.
Pig red blood cell hexokinase: Regulatory characteristics and possible physiological role
Arch. Biochem. Biophys.
226
377-387
1983
Sus scrofa
Steinbck, F.; Choojun, S.; Held, I.; Roehr, M.; Kubicek, C.P.
Characterization and regulatory properties of a single hexokinase from the citric acid accumulating fungus Aspergillus niger
Biochim. Biophys. Acta
1200
215-223
1994
Aspergillus niger
Magnani, M.; Serafini, G.; Stocchi, V.; Bossu, M.; Dacha, M.
Solubilization, purification, and properties of rabbit brain hexokinase
Arch. Biochem. Biophys.
216
449-454
1982
Oryctolagus cuniculus
Rijksen, G.; Staal, G.E.J.; Beks, P.J.; Streefkerk, M.; Akkerman, J.W.N.
Compartmentation of hexokinase in human blood cells. Characterization of soluble and particulate enzymes
Biochim. Biophys. Acta
719
431-437
1982
Homo sapiens
Aubert-Foucher, E.; Font, B.; Gautheron, D.C.
Rabbit heart mitochondrial hexokinase: solubilization and general properties
Arch. Biochem. Biophys.
232
391-399
1984
Oryctolagus cuniculus
Aleshin, A.E.; Zeng, C.; Bourenkov, G.P.; Bartunik, H.D.; Fromm, H.J.; Honzatko, R.B.
The mechanism of regulation of hexokinase: New insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate
Structure
6
39-50
1998
Homo sapiens
Lai, J.C.K.; Behar, K.L.; Liang, B.B.; Hertz, L.
Hexokinase in astrocytes: Kinetic and regulatory properties
Metab. Brain Dis.
14
125-133
1999
Mus musculus
Mulcahy, P.; O'Flaherty, M.; Jennings, L.; Griffin, T.
Application of kinetic-based biospecific affinity chromatographic systems to ATP-dependent enzymes: Studies with yeast hexokinase
Anal. Biochem.
309
279-292
2002
Saccharomyces cerevisiae
Rose, M.
Molecular and biochemical characterization of the hexokinase from the starch-utilizing yeast Schwanniomyces occidentalis
Curr. Genet.
27
330-338
1995
Schwanniomyces occidentalis
Cesar, M.deC.; Colepicolo, P.; Rosa, C.D.; Rosa, R.
Purification and properties of buffalo (Bubalus bubalis) erythrocyte hexokinase
Comp. Biochem. Physiol. B
118
395-401
1997
Bubalus bubalis
Sui, D.; Wilson, J.E.
Purification of the type II and type III isozymes of rat hexokinase, expressed in yeast
Protein Expr. Purif.
24
83-89
2002
Rattus norvegicus
Armstrong, R.L.; Wilson, J.E.; Shoemaker, C.B.
Purification and characterization of the hexokinase from Schistosoma mansoni, expressed in Escherichia coli
Protein Expr. Purif.
8
374-380
1996
Schistosoma mansoni
Schuit, F.; Moens, K.; Heimberg, H.; Pipeleers, D.
Cellular origin of hexokinase in pancreatic islets
J. Biol. Chem.
274
32803-32809
1999
Rattus norvegicus
Doerr, C.; Zaparty, M.; Tjaden, B.; Brinkmann, H.; Siebers, B.
The hexokinase of the hyperthermophile Thermoproteus tenax. ATP-dependent hexokinases and ADP-dependent glucokinases, two alternatives for glucose phosphorylation in Archaea
J. Biol. Chem.
278
18744-18753
2003
Thermoproteus tenax (Q7ZAH1), Thermoproteus tenax
Aleshin, A.E.; Fromm, H.J.; Honzatko, R.B.
Multiple crystal forms of hexokinase I: New insights regarding conformational dynamics, subunit interactions, and membrane association
FEBS Lett.
434
42-46
1998
Homo sapiens
Petit, T.; Blazquez, M.A.; Gancedo, C.
Schizosaccharomyces pombe possesses an unusual and a conventional hexokinase: Biochemical and molecular characterization of both hexokinases
FEBS Lett.
378
185-189
1996
Schizosaccharomyces pombe (P50521), Schizosaccharomyces pombe (Q09756), Schizosaccharomyces pombe, Schizosaccharomyces pombe PB003 (Q09756), Schizosaccharomyces pombe PB004 (P50521)
Aleshin, A.E.; Malfois, M.; Liu, X.; Kim, C.S.; Fromm, H.J.; Honzatko, R.B.; Koch, M.H.J.; Svergun, D.I.
Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution
Biochemistry
38
8359-8366
1999
Homo sapiens (P19367), Homo sapiens
Muzi, M.; Freeman, S.D.; Burrows, R.C.; Wiseman, R.W.; Link, J.M.; Krohn, K.A.; Graham, M.M.; Spence, A.M.
Kinetic characterization of hexokinase isoenzymes from glioma cells: Implications for FDG imaging of human brain tumors
Nucl. Med. Biol.
28
107-116
2001
Bos taurus, Homo sapiens, Rattus norvegicus
Saito, T.; Maeda, T.; Nakazawa, M.; Takeuchi, T.; Nozaki, T.; Asai, T.
Characterisation of hexokinase in Toxoplasma gondii tachyzoites
Int. J. Parasitol.
32
961-967
2002
Toxoplasma gondii (Q969A8), Toxoplasma gondii, Toxoplasma gondii RH (Q969A8)
Palma, F.; Agostini, D.; Mason, P.; Dacha, M.; Piccoli, G.; Biagiarelli, B.; Fiorani, M.; Stocchi, V.
Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein
Mol. Cell. Biochem.
155
23-29
1996
Homo sapiens
Bianchi, M.; Serafini, G.; Bartolucci, E.; Giammarini, C.; Magnani, M.
Enzymatic properties of overexpressed human hexokinase fragments
Mol. Cell. Biochem.
189
185-193
1998
Homo sapiens
Sebastian, S.; Wilson, J.E.; Mulichak, A.; Garavito, R.M.
Allosteric regulation of type I hexokinase: A site-directed mutational study indicating location of the functional glucose 6-phosphate binding site in the N-terminal half of the enzyme
Arch. Biochem. Biophys.
362
203-210
1999
Rattus norvegicus (P05708)
Caceres, A.J.; Portillo, R.; Acosta, H.; Rosales, D.; Quinones, W.; Avilan, L.; Salazar, L.; Dubourdieu, M.; Michels, P.A.M.; Concepcion, J.L.
Molecular and biochemical characterization of hexokinase from Trypanosoma cruzi
Mol. Biochem. Parasitol.
126
251-262
2003
Trypanosoma cruzi (Q8ST54), Trypanosoma cruzi
Kroschewski, H.; Ortner, S.; Steipe, B.; Scheiner, O.; Wiedermann, G.; Duchene, M.
Differences in substrate specificity and kinetic properties of the recombinant hexokinases HXK1 and HXK2 from Entamoeba histolytica
Mol. Biochem. Parasitol.
105
71-80
2000
Entamoeba histolytica, Entamoeba histolytica SFL-3
Cesar, M.deC.; Wilson, J.E.
Functional characteristics of hexokinase bound to the type A and type B sites of bovine brain mitochondria
Arch. Biochem. Biophys.
397
106-112
2002
Bos taurus
Hansen, T.; Reichstein, B.; Schmid, R.; Schonheit, P.
The first archaeal ATP-dependent glucokinase, from the hyperthermophilic crenarchaeon Aeropyrum pernix, represents a monomeric, extremely thermophilic ROK glucokinase with broad hexose specificity
J. Bacteriol.
184
5955-5965
2002
Aeropyrum pernix
Laht, S.; Karp, H.; Kotka, P.; Jarviste, A.; Alamae, T.
Cloning and characterization of glucokinase from a methylotrophic yeast Hansenula polymorpha: different effects on glucose repression in H. polymorpha and Saccharomyces cerevisiae
Gene
296
195-203
2002
Ogataea angusta
Sener, A.; Malaisse, W.J.
Kinetics and specificity of human B-cell glucokinase: relevance to hexose-induced insulin release
Biochim. Biophys. Acta
1312
73-78
1996
Homo sapiens
Xu, L.Z.; Harrison, R.W.; Weber, I.T.; Pilkis, S.J.
Human beta-cell glucokinase. Dual role of Ser-151 in catalysis and hexose affinity
J. Biol. Chem.
270
9939-9946
1995
Homo sapiens
Tu, J.; Tuch, B.E.
Glucose regulates the maximal velocities of glucokinase and glucose utilization in the immature fetal rat pancreatic islet
Diabetes
45
1068-1075
1996
Rattus norvegicus
Takeuchi, H.; Inoue, Y.; Ishihara, H.; Oka, Y.
Overexpression of either liver type or pancreatic beta cell type glucokinase via recombinant adenovirus enhances glucose oxidation in isolated rat hepatocytes
FEBS Lett.
393
60-64
1996
Rattus norvegicus
Roncero, I.; Alvarez, E.; Vazquez, P.; Blazquez, E.
Functional glucokinase isoforms are expressed in rat brain
J. Neurochem.
74
1848-1857
2000
Rattus norvegicus
Marotta, D.E.; Anand, G.R.; Anderson, T.A.; Miller, S.P.; Okar, D.A.; Levitt, D.G.; Lange, A.J.
Identification and characterization of the ATP-binding site in human pancreatic glucokinase
Arch. Biochem. Biophys.
436
23-31
2005
Homo sapiens
Bae, J.; Kim, D.; Choi, Y.; Koh, S.; Park, J.E.; Su Kim, J.; Moon, S.H.; Park, B.H.; Park, M.; Song, H.E.; Hong, S.I.; Lee, D.S.
A hexokinase with broad sugar specificity from a thermophilic bacterium
Biochem. Biophys. Res. Commun.
334
754-763
2005
Thermus caldophilus (Q5RLG0), Thermus caldophilus GK24 (Q5RLG0), Thermus caldophilus GK24
Monasterio, O.; Cardenas, M.L.
Kinetic studies of rat liver hexokinase D ('glucokinase') in non-co-operative conditions show an ordered mechanism with MgADP as the last product to be released
Biochem. J.
371
29-38
2003
Rattus norvegicus
Brocklehurst, K.J.; Davies, R.A.; Agius, L.
Differences in regulatory properties between human and rat glucokinase regulatory protein
Biochem. J.
378
693-697
2004
Homo sapiens, Rattus norvegicus
Sindelar, L.; Sindelarova, M.
Hexokinases of tobacco leaves: Changes in the cytosolic and non-cytosolic isozyme complexes induced by tobacco mosaic virus infection
Biol. Plant.
47
413-419
2003
Nicotiana tabacum
-
Karp, H.; Jarviste, A.; Kriegel, T.M.; Alamae, T.
Cloning and biochemical characterization of hexokinase from the methylotrophic yeast Hansenula polymorpha
Curr. Genet.
44
268-276
2003
Ogataea angusta (Q96VP5), Ogataea angusta
Fernandez-Novell, J.M.; Ballester, J.; Medrano, A.; Otaegui, P.J.; Rigau, T.; Guinovart, J.J.; Rodriguez-Gil, J.E.
The presence of a high-Km hexokinase activity in dog, but not in boar, sperm
FEBS Lett.
570
211-216
2004
Canis lupus familiaris, no activity in Sus scrofa
Giese, J.O.; Herbers, K.; Hoffmann, M.; Klosgen, R.B.; Sonnewald, U.
Isolation and functional characterization of a novel plastidic hexokinase from Nicotiana tabacum
FEBS Lett.
579
827-831
2005
Nicotiana tabacum (Q6Q8A5), Nicotiana tabacum
Gao, H.; Leary, J.A.
Multiplex inhibitor screening and kinetic constant determinations for yeast hexokinase using mass spectrometry based assays
J. Am. Soc. Mass Spectrom.
14
173-181
2003
Saccharomyces cerevisiae
Bar, D.; Golbik, R.; Hubner, G.; Lilie, H.; Muller, E.C.; Naumann, M.; Otto, A.; Reuter, R.; Breunig, K.D.; Kriegel, T.M.
The unique hexokinase of Kluyveromyces lactis. Molecular and functional characterization and evaluation of a role in glucose signaling
J. Biol. Chem.
278
39280-39286
2003
Kluyveromyces lactis (P33284), Kluyveromyces lactis
Kumar, D.P.; Tiwari, A.; Bhat, R.
Effect of pH on the stability and structure of yeast hexokinase A. Acidic amino acid residues in the cleft region are critical for the opening and the closing of the structure
J. Biol. Chem.
279
32093-32099
2004
Saccharomyces cerevisiae (P04807), Saccharomyces cerevisiae
Wilson, J.E.
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function
J. Exp. Biol.
206
2049-2057
2003
Mammalia
Romero, C.S.; Olmo, R.; Teijon, C.; Blanco, M.D.; Teijon, J.M.; Romero, A.
Structural and functional implications of the hexokinase-nickel interaction
J. Inorg. Biochem.
99
2395-2402
2005
Saccharomyces cerevisiae
Andreoni, F.; Serafini, G.; Laguardia, M.E.; Magnani, M.
Bovine hexokinase type I: full-length cDNA sequence and characterisation of the recombinant enzyme
Mol. Cell. Biochem.
268
9-18
2005
Bos taurus (Q5W5U3), Bos taurus
Jangra, A.P.; Malhotra, S.P.; Saharan, M.R.; Singh, R.
Purification and characterization of hexokinase from developing seeds of Brassica campestris L.
Physiol. Mol. Biol. Plants
10
217-222
2004
Brassica rapa subsp. oleifera
-
Grimsby, J.; Sarabu, R.; Corbett, W.L.; Haynes, N.E.; Bizzarro, F.T.; Coffey, J.W.; Guertin, K.R.; Hilliard, D.W.; Kester, R.F.; Mahaney, P.E.; Marcus, L.; Qi, L.; Spence, C.L.; Tengi, J.; Magnuson, M.A.; Chu, C.A.; Dvorozniak, M.T.; Matschinsky, F.M.; Grippo, J.F.
Allosteric activators of glucokinase: potential role in diabetes therapy
Science
301
370-373
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Kamata, K.; Mitsuya, M.; Nishimura, T.; Eiki, J.; Nagata, Y.
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase
Structure
12
429-438
2004
Homo sapiens (P35557)
Kuettner, E.B.; Kriegel, T.M.; Keim, A.; Naumann, M.; Straeter, N.
Crystallization and preliminary X-ray diffraction studies of hexokinase KlHxk1 from Kluyveromyces lactis
Acta Crystallogr. Sect. F
63
430-433
2007
Kluyveromyces lactis
Southworth, R.; Davey, K.A.; Warley, A.; Garlick, P.B.
A reevaluation of the roles of hexokinase I and II in the heart
Am. J. Physiol. Heart Circ. Physiol.
292
H378-H386
2007
Rattus norvegicus (P05708), Rattus norvegicus (P27881)
Soengas, J.L.; Polakof, S.; Chen, X.; Sangiao-Alvarellos, S.; Moon, T.W.
Glucokinase and hexokinase expression and activities in rainbow trout tissues: changes with food deprivation and refeeding
Am. J. Physiol. Regul. Integr. Comp. Physiol.
291
R810-R821
2006
Oncorhynchus mykiss
Miller, S.; Ross-Inta, C.; Giulivi, C.
Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase A: consequences for cancer energy metabolism
Amino Acids
32
593-602
2007
Saccharomyces cerevisiae (P04806), Saccharomyces cerevisiae
Han, B.; Liu, H.; Hu, X.; Cai, Y.; Zheng, D.; Yuan, Z.
Molecular characterization of a glucokinase with broad hexose specificity from Bacillus sphaericus strain C3-41
Appl. Environ. Microbiol.
73
3581-3586
2007
Lysinibacillus sphaericus (A0SZU9), Lysinibacillus sphaericus
Zelent, D.; Najafi, H.; Odili, S.; Buettger, C.; Weik-Collins, H.; Li, C.; Doliba, N.; Grimsby, J.; Matschinsky, F.M.
Glucokinase and glucose homeostasis: proven concepts and new ideas
Biochem. Soc. Trans.
33
306-310
2005
Rattus norvegicus
Heredia, V.V.; Thomson, J.; Nettleton, D.; Sun, S.
Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysis
Biochemistry
45
7553-7562
2006
Homo sapiens
Kim, Y.B.; Kalinowski, S.S.; Marcinkeviciene, J.
A pre-steady state analysis of ligand binding to human glucokinase: evidence for a preexisting equilibrium
Biochemistry
46
1423-1431
2007
Homo sapiens
Jeong, E.J.; Park, K.; Joung, H.A.; Lee, C.S.; Seol, D.W.; Chung, B.H.; Kim, M.
Detection of glucose-induced conformational change in hexokinase II using fluorescence complementation assay
Biotechnol. Lett.
29
797-802
2007
Homo sapiens
Olsen, S.N.; Ramlov, H.; Westh, P.
Effects of osmolytes on hexokinase kinetics combined with macromolecular crowding Test of the osmolyte compatibility hypothesis towards crowded systems
Comp. Biochem. Physiol. A
148
339-345
2007
Saccharomyces cerevisiae
Berradi, H.; Taouis, M.; Cassy, S.; Rideau, N.
Glucokinase in chicken (Gallus gallus). Partial cDNA cloning, immunodetection and activity determination
Comp. Biochem. Physiol. B
141
129-139
2005
Gallus gallus
Kuang, Y.; Schomisch, S.J.; Chandramouli, V.; Lee, Z.
Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma
Comp. Biochem. Physiol. C
143C
225-231
2006
Marmota monax
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Baltrusch, S.; Francini, F.; Lenzen, S.; Tiedge, M.
Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme
Diabetes
54
2829-2837
2005
Rattus norvegicus
Baltrusch, S.; Lenzen, S.
Novel insights into the regulation of the bound and diffusible glucokinase in MIN6 beta-cells
Diabetes
56
1305-1315
2007
Mus musculus
Yang, X.J.; Mastaitis, J.; Mizuno, T.; Mobbs, C.V.
Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression
Endocrinology
148
1928-1932
2007
Mus musculus
Morris, M.T.; DeBruin, C.; Yang, Z.; Chambers, J.W.; Smith, K.S.; Morris, J.C.
Activity of a second Trypanosoma brucei hexokinase is controlled by an 18-amino-acid C-terminal tail
Eukaryot. Cell
5
2014-2023
2006
Trypanosoma brucei (Q95PL2), Trypanosoma brucei
Marin-Hernandez, A.; Rodriguez-Enriquez, S.; Vital-Gonzalez, P.A.; Flores-Rodriguez, F.L.; Macias-Silva, M.; Sosa-Garrocho, M.; Moreno-Sanchez, R.
Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase
FEBS J.
273
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2006
Homo sapiens, Rattus norvegicus
Nishimasu, H.; Fushinobu, S.; Shoun, H.; Wakagi, T.
Identification and characterization of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii
J. Bacteriol.
188
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2006
Sulfurisphaera tokodaii (Q96Y14), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7 (Q96Y14)
Gloyn, A.L.; Odili, S.; Zelent, D.; Buettger, C.; Castleden, H.A.; Steele, A.M.; Stride, A.; Shiota, C.; Magnuson, M.A.; Lorini, R.; dAnnunzio, G.; Stanley, C.A.; Kwagh, J.; van Schaftingen, E.; Veiga-da-Cunha, M.; Barbetti, F.; Dunten, P.; Han, Y.; Grimsby, J.; Taub, R.; Ellard, S.; Hattersley, A.T.
Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young
J. Biol. Chem.
280
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2005
Homo sapiens
Futamura, M.; Hosaka, H.; Kadotani, A.; Shimazaki, H.; Sasaki, K.; Ohyama, S.; Nishimura, T.; Eiki, J.; Nagata, Y.
An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism
J. Biol. Chem.
281
37668-37674
2006
Rattus norvegicus
Sanz-Rodriguez, C.E.; Concepcion, J.L.; Pekerar, S.; Oldfield, E.; Urbina, J.A.
Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies
J. Biol. Chem.
282
12377-12387
2007
Trypanosoma cruzi
Pino, M.F.; Kim, K.A.; Shelton, K.D.; Lindner, J.; Odili, S.; Li, C.; Collins, H.W.; Shiota, M.; Matschinsky, F.M.; Magnuson, M.A.
Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations
J. Biol. Chem.
282
13906-13916
2007
Mus musculus
Bjorkhaug, L.; Molnes, J.; Sovik, O.; Njolstad, P.R.; Flatmark, T.
Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation
J. Biol. Chem.
282
22757-22764
2007
Homo sapiens
Nishimasu, H.; Fushinobu, S.; Shoun, H.; Wakagi, T.
Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii
J. Biol. Chem.
282
9923-9931
2007
Sulfurisphaera tokodaii (Q96Y14), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7 (Q96Y14)
Tsai, H.J.
Function of interdomain alpha-helix in human brain hexokinase: covalent linkage and catalytic regulation between N- and C-terminal halves
J. Biomed. Sci.
14
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2007
Homo sapiens
Sanz, C.; Roncero, I.; Vazquez, P.; Navas, M.A.; Blazquez, E.
Effects of glucose and insulin on glucokinase activity in rat hypothalamus
J. Endocrinol.
193
259-267
2007
Rattus norvegicus
Sorenson, R.L.; Stout, L.E.; Brelje, T.C.; Jetton, T.L.; Matschinsky, F.M.
Immunohistochemical evidence for the presence of glucokinase in the gonadotropes and thyrotropes of the anterior pituitary gland of rat and monkey
J. Histochem. Cytochem.
55
555-566
2007
Macaca fascicularis, Rattus norvegicus
Romero-Navarro, G.; Lopez-Aceves, T.; Rojas-Ochoa, A.; Fernandez Mejia, C.
Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin mRNA levels
Life Sci.
78
1015-1020
2006
Rattus norvegicus
Rui, O.; Hahn, M.
The Botrytis cinerea hexokinase, Hxk1, but not the glucokinase, Glk1, is required for normal growth and sugar metabolism, and for pathogenicity on fruits
Microbiology
153
2791-2802
2007
Botrytis cinerea (A1Z0M7), Botrytis cinerea
Medrano, A.; Garcia-Gil, N.; Ramio, L.; Montserrat Rivera, M.; Fernandez-Novell, J.M.; Ramirez, A.; Pena, A.; Dolors Briz, M.; Pinart, E.; Concha, I.I.; Bonet, S.; Rigau, T.; Rodriguez-Gil, J.E.
Hexose-specificity of hexokinase and ADP-dependence of pyruvate kinase play important roles in the control of monosaccharide utilization in freshly diluted boar spermatozoa
Mol. Reprod. Dev.
73
1179-1194
2006
Sus scrofa
Pabon, M.A.; Caceres, A.J.; Gualdron, M.; Quinones, W.; Avilan, L.; Concepcion, J.L.
Purification and characterization of hexokinase from Leishmania mexicana
Parasitol. Res.
100
803-810
2007
Leishmania mexicana
Claeyssen, E.; Rivoal, J.
Isozymes of plant hexokinase: occurrence, properties and functions
Phytochemistry
68
709-731
2007
Saccharomyces cerevisiae, Solanum lycopersicum, Pisum sativum, Solanum tuberosum, Solanum tuberosum (O64390), Solanum tuberosum (Q9SQ76), Triticum aestivum, Zea mays, Solanum chacoense, Capsicum chacoense, Arabidopsis thaliana (Q9FZG4), Arabidopsis thaliana
Gharbi, I.; Ricard, B.; Rolin, D.; Maucourt, M.; Andrieu, M.H.; Bizid, E.; Smiti, S.; Brouquisse, R.
Effect of hexokinase activity on tomato root metabolism during prolonged hypoxia
Plant Cell Environ.
30
508-517
2007
Solanum lycopersicum, Saccharomyces cerevisiae (P04807), Saccharomyces cerevisiae, Arabidopsis thaliana (Q42525)
Cho, J.I.; Ryoo, N.; Ko, S.; Lee, S.K.; Lee, J.; Jung, K.H.; Lee, Y.H.; Bhoo, S.H.; Winderickx, J.; An, G.; Hahn, T.R.; Jeon, J.S.
Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)
Planta
224
598-611
2006
Oryza sativa, Oryza sativa (Q2KNB5), Oryza sativa (Q2KNB9), Oryza sativa (Q5W676), Oryza sativa (Q6Z398), Oryza sativa (Q8LH82)
Damari-Weissler, H.; Ginzburg, A.; Gidoni, D.; Mett, A.; Krassovskaya, I.; Weber, A.P.; Belausov, E.; Granot, D.
Spinach SoHXK1 is a mitochondria-associated hexokinase
Planta
226
1053-1058
2007
Spinacia oleracea (Q9SEK3), Spinacia oleracea
Claeyssen, E.; Wally, O.; Matton, D.P.; Morse, D.; Rivoal, J.
Cloning, expression, purification, and properties of a putative plasma membrane hexokinase from Solanum chacoense
Protein Expr. Purif.
47
329-339
2006
Solanum chacoense (Q3S2I3), Solanum chacoense
Pedelini, L.; Garcia-Gimeno, M.A.; Marina, A.; Gomez-Zumaquero, J.M.; Rodriguez-Bada, P.; Lopez-Enriquez, S.; Soriguer, F.C.; Cuesta-Munoz, A.L.; Sanz, P.
Structure-function analysis of the alpha5 and the alpha13 helices of human glucokinase: description of two novel activating mutations
Protein Sci.
14
2080-2086
2005
Homo sapiens
Mukhtar, M.H.; Payne, V.A.; Arden, C.; Harbottle, A.; Khan, S.; Lange, A.J.; Agius, L.
Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R766-R774
2008
Rattus norvegicus
Berthels, N.J.; Cordero Otero, R.R.; Bauer, F.F.; Pretorius, I.S.; Thevelein, J.M.
Correlation between glucose/fructose discrepancy and hexokinase kinetic properties in different Saccharomyces cerevisiae wine yeast strains
Appl. Microbiol. Biotechnol.
77
1083-1091
2008
Saccharomyces cerevisiae (P04806), Saccharomyces cerevisiae
Zelent, B.; Odili, S.; Buettger, C.; Shiota, C.; Grimsby, J.; Taub, R.; Magnuson, M.A.; Vanderkooi, J.M.; Matschinsky, F.M.
Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence
Biochem. J.
413
269-280
2008
Homo sapiens
Peng, Q.; Zhou, Q.; Zhou, J.; Zhong, D.; Pan, F.; Liang, H.
Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo
Cancer Biol. Ther.
7
1128-1135
2008
Homo sapiens (P52789), Homo sapiens
Zhang, Y.; Bulur, N.; Peltier, S.; Carpentier, Y.A.; Malaisse, W.J.; Sener, A.
Long-chain fatty acyl-coenzyme A-induced inhibition of glucokinase in pancreatic islets from rats depleted in long-chain polyunsaturated omega3 fatty acids
Cell Biochem. Funct.
26
233-237
2008
Rattus norvegicus
Christesen, H.B.; Tribble, N.D.; Molven, A.; Siddiqui, J.; Sandal, T.; Brusgaard, K.; Ellard, S.; Nj?lstad, P.R.; Alm, J.; Brock Jacobsen, B.; Hussain, K.; Gloyn, A.L.
Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation
Eur. J. Endocrinol.
159
27-34
2008
Homo sapiens
Anderka, O.; Boyken, J.; Aschenbach, U.; Batzer, A.; Boscheinen, O.; Schmoll, D.
Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein - impact of physiological and pharmacological effectors
J. Biol. Chem.
283
31333-31340
2008
Homo sapiens
Estalella, I.; Garcia-Gimeno, M.A.; Marina, A.; Castano, L.; Sanz, P.
Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients
J. Hum. Genet.
53
460-466
2008
Homo sapiens (Q53Y25)
Bertram, L.S.; Black, D.; Briner, P.H.; Chatfield, R.; Cooke, A.; Fyfe, M.C.; Murray, P.J.; Naud, F.; Nawano, M.; Procter, M.J.; Rakipovski, G.; Rasamison, C.M.; Reynet, C.; Schofield, K.L.; Shah, V.K.; Spindler, F.; Taylor, A.; Turton, R.; Williams, G.M.; Wong-Kai-In, P.; Yasuda, K.
SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1
J. Med. Chem.
51
4340-4345
2008
Rattus norvegicus
Jeong, E.J.; Park, K.; Yi, S.Y.; Kang, H.J.; Chung, S.J.; Lee, C.S.; Chung, J.W.; Seol, D.W.; Chung, B.H.; Kim, M.
Stress-governed expression and purification of human type II hexokinase in Escherichia coli
J. Microbiol. Biotechnol.
17
638-643
2007
Homo sapiens (P52789), Homo sapiens
Chambers, J.W.; Fowler, M.L.; Morris, M.T.; Morris, J.C.
The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1
Mol. Biochem. Parasitol.
158
202-207
2008
Trypanosoma brucei
Kim, W.; Yoon, J.H.; Jeong, J.M.; Cheon, G.J.; Lee, T.S.; Yang, J.I.; Park, S.C.; Lee, H.S.
Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma
Mol. Cancer Ther.
6
2554-2562
2007
Mus musculus
Bernardo, S.M.; Gray, K.A.; Todd, R.B.; Cheetham, B.F.; Katz, M.E.
Characterization of regulatory non-catalytic hexokinases in Aspergillus nidulans
Mol. Genet. Genomics
277
519-532
2007
Aspergillus nidulans
Wang, Z.; Gardiner, N.J.; Fernyhough, P.
Blockade of hexokinase activity and binding to mitochondria inhibits neurite outgrowth in cultured adult rat sensory neurons
Neurosci. Lett.
434
6-11
2008
Rattus norvegicus
Singh, A.R.; Joshi, S.; Arya, R.; Kayastha, A.M.; Srivastava, K.K.; Tripathi, L.M.; Saxena, J.K.
Molecular cloning and characterization of Brugia malayi hexokinase
Parasitol. Int.
57
354-361
2008
Brugia malayi (Q56VN6), Brugia malayi
Kuser, P.; Cupri, F.; Bleicher, L.; Polikarpov, I.
Crystal structure of yeast hexokinase PI in complex with glucose: A classical "induced fit" example revised
Proteins
72
731-740
2008
Saccharomyces cerevisiae (P04806), Saccharomyces cerevisiae
Zhuravliova, E.; Barbakadze, T.; Zaalishvili, E.; Chipashvili, M.; Koshoridze, N.; Mikeladze, D.
Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase
Behav. Brain Res.
205
377-383
2009
Rattus norvegicus
Agius, L.
Glucokinase and molecular aspects of liver glycogen metabolism
Biochem. J.
414
1-18
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Riera, A.; Ahuatzi, D.; Herrero, P.; Garcia-Gimeno, M.A.; Sanz, P.; Moreno, F.
Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell
Biochem. J.
415
233-239
2008
Homo sapiens
Veiga-da-Cunha, M.; Sokolova, T.; Opperdoes, F.; Van Schaftingen, E.
Evolution of vertebrate glucokinase regulatory protein from a bacterial N-acetylmuramate 6-phosphate etherase
Biochem. J.
423
323-332
2009
Homo sapiens, Xenopus laevis
Ralph, E.C.; Thomson, J.; Almaden, J.; Sun, S.
Glucose modulation of glucokinase activation by small molecules
Biochemistry
47
5028-5036
2008
Homo sapiens
Sun, S.
Biochemical characterization of MODY2 glucokinase variants V62M and G72R reveals reduced enzymatic activities relative to wild-type
Biochemistry
48
2514-2521
2009
Homo sapiens (P35557), Homo sapiens
Antoine, M.; Boutin, J.A.; Ferry, G.
Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states
Biochemistry
48
5466-5482
2009
Homo sapiens
Larion, M.; Miller, B.G.
23-Residue C-terminal alpha-helix governs kinetic cooperativity in monomeric human glucokinase
Biochemistry
48
6157-6165
2009
Homo sapiens
Zhang, X.; Liang, W.; Mao, Y.; Li, H.; Yang, Y.; Tan, H.
Hepatic glucokinase activity is the primary defect in alloxan-induced diabetes of mice
Biomed. Pharmacother.
63
180-186
2009
Mus musculus
Nishimura, T.; Iino, T.; Mitsuya, M.; Bamba, M.; Watanabe, H.; Tsukahara, D.; Kamata, K.; Sasaki, K.; Ohyama, S.; Hosaka, H.; Futamura, M.; Nagata, Y.; Eiki, J.
Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators
Bioorg. Med. Chem. Lett.
19
1357-1360
2009
Rattus norvegicus
Pfefferkorn, J.A.; Lou, J.; Minich, M.L.; Filipski, K.J.; He, M.; Zhou, R.; Ahmed, S.; Benbow, J.; Perez, A.G.; Tu, M.; Litchfield, J.; Sharma, R.; Metzler, K.; Bourbonais, F.; Huang, C.; Beebe, D.A.; Oates, P.J.
Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
Bioorg. Med. Chem. Lett.
19
3247-3252
2009
Homo sapiens
Zhang, L.; Li, H.; Zhu, Q.; Liu, J.; Chen, L.; Leng, Y.; Jiang, H.; Liu, H.
Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase
Bioorg. Med. Chem.
17
7301-7312
2009
Homo sapiens
Ahn, K.J.; Kim, J.; Yun, M.; Park, J.H.; Lee, J.D.
Enzymatic properties of the N- and C-terminal halves of human hexokinase II
BMB Rep.
42
350-355
2009
Homo sapiens
Iynedjian, P.B.
Molecular physiology of mammalian glucokinase
Cell. Mol. Life Sci.
66
27-42
2009
Rattus norvegicus
Christesen, H.B.; Brusgaard, K.; Beck Nielsen, H.; Brock Jacobsen, B.
Non-insulinoma persistent hyperinsulinaemic hypoglycaemia caused by an activating glucokinase mutation: hypoglycaemia unawareness and attacks
Clin. Endocrinol. (Oxf.)
68
747-755
2008
Homo sapiens
Polakof, S.; Rodriguez-Alonso, M.; Soengas, J.L.
Immunohistochemical localization of glucokinase in rainbow trout brain
Comp. Biochem. Physiol. A
153
352-358
2009
Oncorhynchus mykiss
Grimsby, J.; Berthel, S.J.; Sarabu, R.
Glucokinase activators for the potential treatment of type 2 diabetes
Curr. Top. Med. Chem.
8
1524-1532
2008
Homo sapiens
Wei, P.; Shi, M.; Barnum, S.; Cho, H.; Carlson, T.; Fraser, J.D.
Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells
Diabetologia
52
2142-2150
2009
Rattus norvegicus
Wang, T.; Kang, J.
Hexokinase inhibitor screening based on adenosine 5-diphosphate determination by electrophoretically mediated microanalysis
Electrophoresis
30
1349-1354
2009
Saccharomyces cerevisiae
Coghlan, M.; Leighton, B.
Glucokinase activators in diabetes management
Expert Opin. Investig. Drugs
17
145-167
2008
Homo sapiens
Molnes, J.; Bjorkhaug, L.; Sovik, O.; Njolstad, P.R.; Flatmark, T.
Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions
FEBS J.
275
2467-2481
2008
Homo sapiens (P35557), Homo sapiens
Beer, N.L.; Tribble, N.D.; McCulloch, L.J.; Roos, C.; Johnson, P.R.; Orho-Melander, M.; Gloyn, A.L.
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
Hum. Mol. Genet.
18
4081-4088
2009
Homo sapiens
Osbak, K.K.; Colclough, K.; Saint-Martin, C.; Beer, N.L.; Bellanne-Chantelot, C.; Ellard, S.; Gloyn, A.L.
Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia
Hum. Mutat.
30
1512-1526
2009
Homo sapiens
Lengsfeld, C.; Schoenert, S.; Dippel, R.; Boos, W.
Glucose- and glucokinase-controlled mal gene expression in Escherichia coli
J. Bacteriol.
191
701-712
2009
Thermus thermophilus
Cifuentes, D.; Martinez-Pons, C.; Garcia-Rocha, M.; Galina, A.; Ribas de Pouplana, L.; Guinovart, J.J.
Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver
J. Biol. Chem.
283
5642-5649
2008
Rattus norvegicus
Kim, T.H.; Kim, H.; Park, J.M.; Im, S.S.; Bae, J.S.; Kim, M.Y.; Yoon, H.G.; Cha, J.Y.; Kim, K.S.; Ahn, Y.H.
Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver
J. Biol. Chem.
284
15071-15083
2009
Mus musculus
Sawada, K.; Taki, A.; Yamakawa, T.; Seki, M.
Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42
J. Biosci. Bioeng.
108
385-390
2009
Moniliella megachiliensis, Moniliella megachiliensis SN-G42
Polakof, S.; Miguez, J.M.; Soengas, J.L.
A hepatic protein modulates glucokinase activity in fish and avian liver: a comparative study
J. Comp. Physiol. B
179
643-652
2009
Carassius auratus, Cyprinus carpio, Gallus gallus, Oncorhynchus mykiss, Rattus norvegicus
Genabai, N.K.; Vavaiya, K.V.; Briski, K.P.
Adaptation of glucokinase gene expression in the rat dorsal vagal complex in a model for recurrent intermediate insulin-induced hypoglycemia: impact of gender
J. Mol. Neurosci.
37
80-85
2009
Rattus norvegicus
Roncero, I.; Sanz, C.; Alvarez, E.; Vazquez, P.; Barrio, P.A.; Blazquez, E.
Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain
J. Neuroendocrinol.
21
973-981
2009
Rattus norvegicus
Vilches-Flores, A.; Tovar, A.R.; Marin-Hernandez, A.; Rojas-Ochoa, A.; Fernandez-Mejia, C.
Biotin increases glucokinase expression via soluble guanylate cyclase/protein kinase G, adenosine triphosphate production and autocrine action of insulin in pancreatic rat islets
J. Nutr. Biochem.
21
606-612
2009
Rattus norvegicus
Bhaskar, P.T.; Nogueira, V.; Patra, K.C.; Jeon, S.M.; Park, Y.; Robey, R.B.; Hay, N.
mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition
Mol. Cell. Biol.
29
5136-5147
2009
Mus musculus
Zhang, J.; Li, C.; Shi, T.; Chen, K.; Shen, X.; Jiang, H.
Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis
PLoS ONE
4
e6304
2009
Homo sapiens (P19367)
Hiskett, E.K.; Suwitheechon, O.U.; Lindbloom-Hawley, S.; Boyle, D.L.; Schermerhorn, T.
Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver
Vet. Res. Commun.
33
227-240
2009
Canis lupus familiaris, Felis catus, Rattus norvegicus
Petit, P.; Antoine, M.; Ferry, G.; Boutin, J.A.; Lagarde, A.; Gluais, L.; Vincentelli, R.; Vuillard, L.
The active conformation of human glucokinase is not altered by allosteric activators
Acta Crystallogr. Sect. D
67
929-935
2011
Homo sapiens (P35557)
Zelent, B.; Odili, S.; Buettger, C.; Zelent, D.K.; Chen, P.; Fenner, D.; Bass, J.; Stanley, C.; Laberge, M.; Vanderkooi, J.M.; Sarabu, R.; Grimsby, J.; Matschinsky, F.M.
Mutational analysis of allosteric activation and inhibition of glucokinase
Biochem. J.
440
203-215
2011
Homo sapiens (P35557)
Bourbonais, F.J.; Chen, J.; Huang, C.; Zhang, Y.; Pfefferkorn, J.A.; Landro, J.A.
Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis
Biochem. J.
441
881-887
2012
Homo sapiens
Zelent, B.; Buettger, C.; Grimsby, J.; Sarabu, R.; Vanderkooi, J.M.; Wand, A.J.; Matschinsky, F.M.
Thermal stabilty of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea
Biochim. Biophys. Acta
1824
769-784
2012
Homo sapiens
Cheng, W.; Zhang, H.; Zhou, X.; Liu, H.; Liu, Y.; Li, J.; Han, S.; Wang, Y.
Subcellular localization of rice hexokinase (OsHXK) family members in the mesophyll protoplasts of tobacco
Biol. Plant.
55
173-177
2011
Oryza sativa, Oryza sativa (Q1WM16), Oryza sativa (Q2KNB4), Oryza sativa (Q2KNB5), Oryza sativa (Q2KNB7), Oryza sativa (Q2KNB9), Oryza sativa (Q5W676), Oryza sativa (Q6Z398), Oryza sativa (Q8LH82), Oryza sativa (Q8LQ68)
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Li, F.; Zhu, Q.; Zhang, Y.; Feng, Y.; Leng, Y.; Zhang, A.
Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators
Bioorg. Med. Chem.
18
3875-3884
2010
Homo sapiens
Mao, W.; Ning, M.; Liu, Z.; Zhu, Q.; Leng, Y.; Zhang, A.
Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators
Bioorg. Med. Chem.
20
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2012
Homo sapiens
Nilsson, A.; Olsson, T.; Ulfstedt, M.; Thelander, M.; Ronne, H.
Two novel types of hexokinases in the moss Physcomitrella patens
BMC Plant Biol.
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32
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Physcomitrium patens (A9RE08), Physcomitrium patens (A9RIW3), Physcomitrium patens (A9S3H4), Physcomitrium patens (A9S9F8), Physcomitrium patens (A9SJG4), Physcomitrium patens (A9SV13), Physcomitrium patens (A9TDS4), Physcomitrium patens (A9TLJ2), Physcomitrium patens (A9U0F4), Physcomitrium patens (A9U189), Physcomitrium patens (Q6X271), Physcomitrium patens
Moisan, M.; Rivoal, J.
Purification to homogeneity and characterization of nonproteolyzed potato (Solanum tuberosum) tuber hexokinase 1
Botany
89
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2011
Solanum tuberosum
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Dieni, C.A.; Storey, K.B.
Regulation of hexokinase by reversible phosphorylation in skeletal muscle of a freeze-tolerant frog
Comp. Biochem. Physiol. B
159
236-243
2011
Lithobates sylvaticus
Molnes, J.; Teigen, K.; Aukrust, I.; Bjorkhaug, L.; Sovik, O.; Flatmark, T.; Njolstad, P.R.
Binding of ATP at the active site of human pancreatic glucokinase--nucleotide-induced conformational changes with possible implications for its kinetic cooperativity
FEBS J.
278
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2011
Homo sapiens
Zhang, Z.W.; Yuan, S.; Xu, F.; Yang, H.; Zhang, N.H.; Cheng, J.; Lin, H.H.
The plastid hexokinase pHXK: a node of convergence for sugar and plastid signals in Arabidopsis
FEBS Lett.
584
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Arabidopsis thaliana
Liu, Q.; Shen, Y.; Liu, S.; Weng, J.; Liu, J.
Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site
FEBS Lett.
585
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2011
Homo sapiens (P35557)
Leite, T.C.; Coelho, R.G.; Da Silva, D.; Coelho, W.S.; Marinho-Carvalho, M.M.; Sola-Penna, M.
Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice
FEBS Lett.
585
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2011
Mus musculus
Kuettner, E.B.; Kettner, K.; Keim, A.; Svergun, D.I.; Volke, D.; Singer, D.; Hoffmann, R.; Mueller, E.C.; Otto, A.; Kriegel, T.M.; Straeter, N.
Crystal structure of hexokinase KlHxk1 of Kluyveromyces lactis: a molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization
J. Biol. Chem.
285
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2010
Kluyveromyces lactis (P33284), Kluyveromyces lactis
Dodson, H.C.; Morris, M.T.; Morris, J.C.
Glycerol 3-phosphate alters Trypanosoma brucei hexokinase activity in response to environmental change
J. Biol. Chem.
286
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2011
Trypanosoma brucei
Nakamura, T.; Kashima, Y.; Mine, S.; Oku, T.; Uegaki, K.
Characterization and crystal structure of the thermophilic ROK hexokinase from Thermus thermophilus
J. Biosci. Bioeng.
114
150-154
2012
Thermus thermophilus (Q5SLJ4), Thermus thermophilus
Wolf, A.; Agnihotri, S.; Micallef, J.; Mukherjee, J.; Sabha, N.; Cairns, R.; Hawkins, C.; Guha, A.
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
J. Exp. Med.
208
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2011
Homo sapiens
Troncoso-Ponce, M.A.; Rivoal, J.; Dorion, S.; Moisan, M.C.; Garces, R.; Martinez-Force, E.
Cloning, biochemical characterization and expression of a sunflower (Helianthus annuus L.) hexokinase associated with seed storage compounds accumulation
J. Plant Physiol.
168
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Helianthus annuus (B8K2W7), Helianthus annuus
Kim, Y.; Heinzel, N.; Giese, J.; Koeber, J.; Melzer, M.; Rutten, T.; Von Wiren, N.; Sonnewald, U.; Hajirezaei, M.
A dual role of tobacco hexokinase 1 in primary metabolism and sugar sensing
Plant Cell Environ.
36
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Nicotiana tabacum
Karve, A.; Xia, X.; Moore, B.d.
Arabidopsis Hexokinase-Like1 and Hexokinase1 form a critical node in mediating plant glucose and ethylene responses
Plant Physiol.
158
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Arabidopsis thaliana, Arabidopsis thaliana (Q42525)
Fukumoto, T.; Kano, A.; Ohtani, K.; Inoue, M.; Yoshihara, A.; Izumori, K.; Tajima, S.; Shigematsu, Y.; Tanaka, K.; Ohkouchi, T.; Ishida, Y.; Nishizawa, Y.; Tada, Y.; Ichimura, K.; Gomi, K.; Yoo, S.D.; Sheen, J.; Akimitsu, K.
Phosphorylation of D-allose by hexokinase involved in regulation of OsABF1 expression for growth inhibition in Oryza sativa L
Planta
237
1379-1391
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Arabidopsis thaliana, Oryza sativa
Larion, M.; Salinas, R.; Bruschweiler-Li, L.; Miller, B.; Brschweiler, R.
Order-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase
PLoS Biol.
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Homo sapiens
John, S.; Weiss, J.N.; Ribalet, B.
Subcellular localization of hexokinases I and II directs the metabolic fate of glucose
PLoS ONE
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Rattus norvegicus
Claeyssen, E.; Dorion, S.; Clendenning, A.; He, J.Z.; Wally, O.; Chen, J.; Auslender, E.L.; Moisan, M.C.; Jolicoeur, M.; Rivoal, J.
The futile cycling of hexose phosphates could account for the fact that hexokinase exerts a high control on glucose phosphorylation but not on glycolytic rate in transgenic potato (Solanum tuberosum) roots
PLoS ONE
8
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Solanum tuberosum
Mergenthaler, P.; Kahl, A.; Kamitz, A.; van Laak, V.; Stohlmann, K.; Thomsen, S.; Klawitter, H.; Przesdzing, I.; Neeb, L.; Freyer, D.; Priller, J.; Collins, T.J.; Megow, D.; Dirnagl, U.; Andrews, D.W.; Meisel, A.
Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state
Proc. Natl. Acad. Sci. USA
109
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2012
Rattus norvegicus
Lilie, H.; Baer, D.; Kettner, K.; Weininger, U.; Balbach, J.; Naumann, M.; Mueller, E.C.; Otto, A.; Gast, K.; Golbik, R.; Kriegel, T.
Yeast hexokinase isoenzyme ScHxk2: stability of a two-domain protein with discontinuous domains
Protein Eng. Des. Sel.
24
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2011
Saccharomyces cerevisiae (P04807), Saccharomyces cerevisiae
Bowler, J.; Hervert, K.; Kearley, M.; Miller, B.
Small-molecule allosteric activation of human glucokinase in the absence of glucose
ACS Med. Chem. Lett.
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Homo sapiens
Lin, H.; Zeng, J., Xie, R.; Schulz, M.J.; Tedesco, R.; Qu, J.; Erhard, K.F.; Mack, J.F.; Raha, K.; Rendina, A.R.; Szewczuk, L.M.; Kratz, P.M.; Jurewicz, A.J.; Cecconie, T.; Martens, S.; McDevitt, P.J.; Martin, J.D.; Chen, S.B.; Jiang, Y.; Nickels, L.; Schwartz, B.J.; Smallwood, A.; Zhao, B.; Campobasso, N.; Qian, Y.; Briand, J.; Rominger, C.M.; Oleykowski, C.; Hardwicke, M.A.; Luengo, J.I.
Discovery of a novel 2,6-disubstituted glucosamine series of potent and selective hexokinase 2 inhibitors
ACS Med. Chem. Lett.
7
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2015
Homo sapiens (P19367), Homo sapiens (P52789)
Dransfield, P.J.; Pattaropong, V.; Lai, S.; Fu, Z.; Kohn, T.J.; Du, X.; Cheng, A.; Xiong, Y.; Komorowski, R.; Jin, L.; Conn, M.; Tien, E.; DeWolf, W.E.; Hinklin, R.J.; Aicher, T.D.; Kraser, C.F.; Boyd, S.A.; Voegtli, W.C.; Condroski, K.R.; Veniant-Ellison, M.; Medina, J.C.; Houze, J.; Coward, P.
Novel series of potent glucokinase activators leading to the discovery of AM-2394
ACS Med. Chem. Lett.
7
714-718
2016
Homo sapiens (P52789)
Lin, X.W.; Xu, W.H.
Hexokinase is a key regulator of energy metabolism and ROS activity in insect lifespan extension
Aging
8
245-259
2016
Helicoverpa armigera (A0A0P0I1H5), Helicoverpa armigera
Fichera, G.A.; Fichera, M.; Milone, G.
Antitumoural activity of a cytotoxic peptide of Lactobacillus casei peptidoglycan and its interaction with mitochondrial-bound hexokinase
Anticancer Drugs
27
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2016
Mus musculus
Davis, M.I.; Patrick, S.; Blanding, W.M.; Dwivedi, V.; Suryadi, J.; Golden, J.E.; Coussens, N.P.; Lee, O.W.; Shen, M.; Boxer, M.B.; Hall, M.D.; Sharlow, E.R.; Drew, M.E.; Morris, J.C.
Identification of novel Plasmodium falciparum hexokinase inhibitors with anti-parasitic activity
Antimicrob. Agents Chemother.
60
6023-6033
2016
Plasmodium falciparum (Q02155), Plasmodium falciparum
Hayashi, H.; Sato, Y.; Li, Z.; Yamamura, K.; Yoshizawa, T.; Yamagata, K.
Roles of hepatic glucokinase in intertissue metabolic communication: Examination of novel liver-specific glucokinase knockout mice
Biochem. Biophys. Res. Commun.
460
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2015
Mus musculus
Zhuo, B.; Li, Y.; Li, Z.; Qin, H.; Sun, Q.; Zhang, F.; Shen, Y.; Shi, Y.; Wang, R.
PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma
Biochem. Biophys. Res. Commun.
464
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2015
Homo sapiens
Baldini, S.F.; Steenackers, A.; Olivier-Van Stichelen, S.; Mir, A.M.; Mortuaire, M.; Lefebvre, T.; Guinez, C.
Glucokinase expression is regulated by glucose through O-GlcNAc glycosylation
Biochem. Biophys. Res. Commun.
478
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Mus musculus
Hofmeister-Brix, A.; Lenzen, S.; Baltrusch, S.
The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic beta-cells
Biochem. J.
456
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Mus musculus
Khu, L.Y.; Storey, K.B.; Rubtsov, A.M.; Goncharova, N.Y.
Regulation of glucokinase activity in liver of hibernating ground squirrel Spermophilus undulatus
Biochemistry (Moscow)
79
727-732
2014
Urocitellus undulatus
Kumar, S.; Parameswaran, S.; Sharma, R.K.
Novel myristoylation of the sperm-specific hexokinase 1 isoform regulates its atypical localization
Biol. Open
4
1679-1687
2015
Homo sapiens (P19367)
Bryan, N.; Raisch, K.
Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II
Biosci. Rep.
35
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Homo sapiens
Lindbloom-Hawley, S.; LeCluyse, M.; Vandersande, V.; Lushington, G.; Schermerhorn, T.
Cloning and characterization of feline islet glucokinase
BMC Vet. Res.
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130
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Felis catus (A3EYB3)
Sen, S.; Kaminiski, R.; Deshmane, S.; Langford, D.; Khalili, K.; Amini, S.; Datta, P.K.
Role of hexokinase-1 in the survival of HIV-1-infected macrophages
Cell Cycle
14
980-989
2015
Homo sapiens
Lama, J.L.; Bell, R.A.; Storey, K.B.
Hexokinase regulation in the hepatopancreas and foot muscle of the anoxia-tolerant marine mollusc, Littorina littorea
Comp. Biochem. Physiol. B
166
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2013
Littorina littorea
Ermakova, E.
Structural insight into the glucokinase-ligands interactions. Molecular docking study
Comput. Biol. Chem.
64
281-296
2016
Homo sapiens (P35557)
Preller, A.; Wilson, C.A.; Quiroga-Roger, D.; Ureta, T.
Hexokinase and not glycogen synthase controls the flux through the glycogen synthesis pathway in frog oocytes
FEBS Lett.
587
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Xenopus laevis
Tjhin, E.T.; Staines, H.M.; van Schalkwyk, D.A.; Krishna, S.; Saliba, K.J.
Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis
FEBS Lett.
587
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2013
Plasmodium falciparum
Li, M.; Gao, Z.; Wang, Y.; Wang, H.; Zhang, S.
Identification, expression and bioactivity of hexokinase in amphioxus: insights into evolution of vertebrate hexokinase genes
Gene
535
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Branchiostoma japonicum (V5KAK3), Branchiostoma japonicum
Fraga, A.; Moraes, J.; da Silva, J.R.; Costa, E.P.; Menezes, J.; da Silva Vaz, I.; Logullo, C.; da Fonseca, R.N.; Campos, E.
Inorganic polyphosphates regulate hexokinase activity and reactive oxygen species generation in mitochondria of Rhipicephalus (Boophilus) microplus embryo
Int. J. Biol. Sci.
9
842-852
2013
Rhipicephalus microplus
Jin, L.; Guo, T.; Li, Z.; Lei, Z.; Li, H.; Mao, Y.; Wang, X.; Zhou, N.; Zhang, Y.; Hu, R.; Zhang, X.; Niu, G.; Irwin, D.M.; Tan, H.
Role of glucokinase in the subcellular localization of glucokinase regulatory protein
Int. J. Mol. Sci.
16
7377-7393
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Mus musculus, Rattus norvegicus
Markwardt, M.L.; Seckinger, K.M.; Rizzo, M.A.
Regulation of glucokinase by intracellular calcium levels in pancreatic beta cells
J. Biol. Chem.
291
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Mus musculus
Yellapu, N.; Mahto, M.K.; Valasani, K.R.; Sarma, P.V.; Matcha, B.
Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding - explains hyperglycemia in type 2 diabetic patients
J. Biomol. Struct. Dyn.
33
820-833
2015
Homo sapiens
Hussain, S.; Richardson, E.; Ma, Y.; Holton, C.; De Backer, I.; Buckley, N.; Dhillo, W.; Bewick, G.; Zhang, S.; Carling, D.; Bloom, S.; Gardiner, J.
Glucokinase activity in the arcuate nucleus regulates glucose intake
J. Clin. Invest.
125
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2015
Rattus norvegicus (P17712)
Cakir, B.
Identification and structure of six members of the hexokinase gene family in Vitis vinifera: Cloning, expression, and functional analysis of a putative chloroplast stromal-type hexokinase
J. Hortic. Sci. Biotechnol.
89
663-673
2014
Vitis vinifera (F6H088)
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Kim, H.B.; Cho, J.I.; Ryoo, N.; Shin, D.H.; Park, Y.I.; Hwang, Y.S.; Lee, S.K.; An, G.; Jeon, J.S.
Role of rice cytosolic hexokinase OsHXK7 in sugar signaling and metabolism
J. Integr. Plant Biol.
58
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2016
Oryza sativa Japonica Group (Q1WM16)
Pandurangan, M.; Enkhtaivan, G.; Kim, D.H.
Homobrassinolide induced conformational changes in hexokinase: a possible mechanism for its antidiabetic potential
J. Mol. Recognit.
29
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2016
Homo sapiens (P35557), Homo sapiens
Lazar, Z.; Dulermo, T.; Neuveglise, C.; Crutz-Le Coq, A.M.; Nicaud, J.M.
Hexokinase - A limiting factor in lipid production from fructose in Yarrowia lipolytica
Metab. Eng.
26
89-99
2014
Yarrowia lipolytica (O74996), Yarrowia lipolytica
Zhang, Z.; Zhang, J.; Chen, Y.; Li, R.; Wang, H.; Ding, L.; Wei, J.
Isolation, structural analysis, and expression characteristics of the maize (Zea mays L.) hexokinase gene family
Mol. Biol. Rep.
41
6157-6166
2014
Zea mays (A0A1D6MAK9), Zea mays (A0A1D6NCX2), Zea mays
Zhang, Y.; Zhen, L.; Tan, X.; Li, L.; Wang, X.
The involvement of hexokinase in the coordinated regulation of glucose and gibberellin on cell wall invertase and sucrose synthesis in grape berry
Mol. Biol. Rep.
41
7899-7910
2014
Vitis vinifera, Vitis vinifera cv. Cabernet Sauvignon
Roberts, D.J.; Tan-Sah, V.P.; Ding, E.Y.; Smith, J.M.; Miyamoto, S.
Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition
Mol. Cell
53
521-533
2014
Rattus norvegicus (P27881)
Sun, M.; Liao, S.; Zhang, L.; Wu, C.; Qi, N.; Lv, M.; Li, J.; Lin, X.; Zhang, J.; Xie, M.; Zhu, G.; Cai, J.
Molecular and biochemical characterization of Eimeria tenella hexokinase
Parasitol. Res.
115
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Eimeria tenella (A0A172WCE4), Eimeria tenella
Wang, X.Q.; Li, L.M.; Yang, P.P.; Gong, C.L.
The role of hexokinases from grape berries (Vitis vinifera L.) in regulating the expression of cell wall invertase and sucrose synthase genes
Plant Cell Rep.
33
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2014
Vitis vinifera
Chen, T.; Yu, J.; Tang, Z.; Xie, Z.; Lin, Z.; Sun, H.; Wan, S.; Li, X.; Huang, Y.; Yu, X.; Xu, J.
Advanced enzymology, expression profile and immune response of Clonorchis sinensis hexokinase show its application potential for prevention and control of clonorchiasis
PLoS Negl. Trop. Dis.
9
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2015
Clonorchis sinensis
Bergdahl, B.; Sandstroem, A.G.; Borgstroem, C.; Boonyawan, T.; van Niel, E.W.; Gorwa-Grauslund, M.F.
Engineering yeast hexokinase 2 for improved tolerance toward xylose-induced inactivation
PLoS ONE
8
e75055
2013
Saccharomyces cerevisiae (P04806), Saccharomyces cerevisiae
Kelly, G.; Sade, N.; Attia, Z.; Secchi, F.; Zwieniecki, M.; Holbrook, N.; Levi, A.; Alchanatis, V.; Moshelion, M.; Granot, D.
Relationship between hexokinase and the aquaporin PIP1 in the regulation of photosynthesis and plant growth
PLoS ONE
9
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2014
Arabidopsis thaliana (Q42525)
Childers, C.L.; Storey, K.B.
Post-translational regulation of hexokinase function and protein stability in the aestivating frog Xenopus laevis
Protein J.
35
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2016
Xenopus laevis
Martinez, J.A.; Larion, M.; Conejo, M.S.; Porter, C.M.; Miller, B.G.
Role of connecting loop I in catalysis and allosteric regulation of human glucokinase
Protein Sci.
23
915-922
2014
Homo sapiens (P35557), Homo sapiens
Yu, Y.; Zhang, H.; Guo, F.; Sun, M.; Zhu, G.
A unique hexokinase in Cryptosporidium parvum, an apicomplexan pathogen lacking the Krebs cycle and oxidative phosphorylation
Protist
165
701-714
2014
Cryptosporidium parvum (Q5CWT5), Cryptosporidium parvum, Cryptosporidium parvum Iowa II (Q5CWT5)
Nakamura, T.; Kashima, Y.; Mine, S.; Oku, T.; Uegaki, K.
Characterization and crystal structure of the thermophilic ROK hexokinase from Thermus thermophilus
J. Biosci. Bioeng.
114
150-154
2012
Thermus thermophilus (Q5SLJ4), Thermus thermophilus, Thermus thermophilus DSM 579 (Q5SLJ4)
Milanes, J.E.; Suryadi, J.; Abendroth, J.; Van Voorhis, W.C.; Barrett, K.F.; Dranow, D.M.; Phan, I.Q.; Patrick, S.L.; Rozema, S.D.; Khalifa, M.M.; Golden, J.E.; Morris, J.C.
Enzymatic and structural characterization of the Naegleria fowleri glucokinase
Antimicrob. Agents Chemother.
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2019
Homo sapiens (P35557)
Heneberg, P.
Redox regulation of hexokinases
Antioxid. Redox Signal.
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415-442
2019
Oryctolagus cuniculus, Trypanosoma brucei, Mus musculus (P17710), Homo sapiens (P19367), Homo sapiens (P52789), Homo sapiens (P52790), Plasmodium falciparum (Q02155)
He, C.; Chen, J.; Wang, H.; Wan, Y.; Zhou, J.; Dan, Z.; Zeng, Y.; Xu, W.; Zhu, Y.; Huang, W.; Yin, L.
Crystal structures of rice hexokinase 6 with a series of substrates shed light on its enzymatic mechanism
Biochem. Biophys. Res. Commun.
515
614-620
2019
Oryza sativa Japonica Group (Q8LQ68)
Casey, A.K.; Miller, B.G.
Kinetic Basis of carbohydrate-mediated inhibition of human glucokinase by the glucokinase regulatory protein
Biochemistry
55
2899-2902
2016
Homo sapiens
Tesinsky, M.; Simcikova, D.; Heneberg, P.
First evidence of changes in enzyme kinetics and stability of glucokinase affected by somatic cancer-associated variations
Biochim. Biophys. Acta Proteins Proteom.
1867
213-218
2019
Homo sapiens
Cornish-Bowden, A.
Zacharias Dische and the discovery of feedback inhibition A landmark paper published in the forerunner of Biochimie
Biochimie
182
120-130
2021
Homo sapiens
Liu, Y.; Li, M.; Zhang, Y.; Wu, C.; Yang, K.; Gao, S.; Zheng, M.; Li, X.; Li, H.; Chen, L.
Structure based discovery of novel hexokinase 2 inhibitors
Bioorg. Chem.
96
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2020
Homo sapiens (P52789), Homo sapiens
Kochel, K.; Tomczyk, M.; Simoes, R.; Fraczek, T.; Sobon, A.; Oliveira, P.; Walczak, K.; Koceva-Chyla, A.
Evaluation of biological properties of 3,3',4,4'-benzophenonetetracarboxylic dianhydride derivatives and their ability to inhibit hexokinase activity
Bioorg. Med. Chem. Lett.
27
427-431
2017
Mus musculus (O08528)
Nawaz, M.H.; Ferreira, J.C.; Nedyalkova, L.; Zhu, H.; Carrasco-Lopez, C.; Kirmizialtin, S.; Rabeh, W.M.
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation
Biosci. Rep.
38
BSR20171666
2018
Homo sapiens (P52789), Homo sapiens
Dische, Z.
Sur l'interdependance des divers enzymes du systeme glycolytique et sur la regulation automatique de leur activite dans les cellules
Bull. Soc. Chim. Biol.
23
1140-1148
1941
Homo sapiens
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Roth, M.S.; Westcott, D.J.; Iwai, M.; Niyogi, K.K.
Hexokinase is necessary for glucose-mediated photosynthesis repression and lipid accumulation in a green alga
Commun. Biol.
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Chromochloris zofingiensis
Wang, Z.; Shi, X.; Zhang, H.; Yu, L.; Cheng, Y.; Zhang, H.; Zhang, H.; Zhou, J.; Chen, J.; Shen, X.; Duan, W.
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators Design, synthesis, and biological evaluation
Eur. J. Med. Chem.
139
128-152
2017
Homo sapiens
Bao, F.; Yang, K.; Wu, C.; Gao, S.; Wang, P.; Chen, L.; Li, H.
New natural inhibitors of hexokinase 2 (HK2) Steroids from Ganoderma sinense
Fitoterapia
125
123-129
2018
Homo sapiens (P52789)
Sun, S.; Xuan, F.; Fu, H.; Zhu, J.; Ge, X.
Molecular cloning and functional characterization of a hexokinase from the oriental river prawn Macrobrachium nipponense in response to hypoxia
Int. J. Mol. Sci.
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1256
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Macrobrachium nipponense (A0A220NLA7), Macrobrachium nipponense
Aljamal, J.; Badawneh, M.
In vitro inhibition of human erythrocyte hexokinase by various hyperglycemic drugs
J. Biochem. Mol. Toxicol.
31
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2017
Homo sapiens (P19367), Homo sapiens
Ziamajidi, N.; Jamshidi, S.; Ehsani-Zonouz, A.
In-silico and in-vitro investigation on the phenylalanine metabolites' interactions with hexokinase of Rat's brain mitochondria
J. Bioenerg. Biomembr.
49
139-147
2017
Rattus norvegicus (P05708)
Karro, N.; Sepp, M.; Jugai, S.; Laasmaa, M.; Vendelin, M.; Birkedal, R.
Metabolic compartmentation in rainbow trout cardiomyocytes coupling of hexokinase but not creatine kinase to mitochondrial respiration
J. Comp. Physiol. B
187
103-116
2017
Oncorhynchus mykiss
Khan, M.W.; Ding, X.; Cotler, S.J.; Clarke, M.; Layden, B.T.
Studies on the tissue localization of HKDC1, a putative novel fifth hexokinase, in humans
J. Histochem. Cytochem.
66
385-392
2018
Homo sapiens (Q2TB90), Homo sapiens
Zhang, L.; Li, B.; Zhang, Y.; Jia, X.; Zhou, M.
Hexokinase plays a critical role in deoxynivalenol (DON) production and fungal development in Fusarium graminearum
Mol. Plant Pathol.
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16-28
2016
Fusarium graminearum (I1RAH1), Fusarium graminearum (I1RGY2), Fusarium graminearum, Fusarium graminearum ATCC MYA-4620 (I1RAH1)
Van Dingenen, J.; Vermeersch, M.; De Milde, L.; Hulsmans, S.; De Winne, N.; Van Leene, J.; Gonzalez, N.; Dhondt, S.; De Jaeger, G.; Rolland, F.; Inze, D.
The role of HEXOKINASE1 in Arabidopsis leaf growth
Plant Mol. Biol.
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79-93
2019
Arabidopsis thaliana (Q42525)
Roh, J.I.; Kim, Y.; Oh, J.; Kim, Y.; Lee, J.; Lee, J.; Chun, K.H.; Lee, H.W.
Hexokinase 2 is a molecular bridge linking telomerase and autophagy
PLoS ONE
13
e0193182
2018
Homo sapiens (P52789)
Wang, L.; Dong, Q.; Zhu, Q.; Tang, N.; Jia, S.; Xi, C.; Zhao, H.; Han, S.; Wang, Y.
Conformational characteristics of rice hexokinase OsHXK7 as a moonlighting protein involved in sugar signalling and metabolism
Protein J.
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249-256
2017
Oryza sativa Japonica Group (Q1WM16)
Simcikova, D.; Heneberg, P.
Identification of alkaline pH optimum of human glucokinase because of ATP-mediated bias correction in outcomes of enzyme assays
Sci. Rep.
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11422
2019
Homo sapiens (P35557), Homo sapiens
Yin, X.; Choudhury, M.; Kang, J.H.; Schaefbauer, K.J.; Jung, M.Y.; Andrianifahanana, M.; Hernandez, D.M.; Leof, E.B.
Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-beta
Sci. Signal.
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eaax4067
2019
Homo sapiens (P52789), Homo sapiens, Mus musculus (O08528), Mus musculus
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