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Disease on EC 2.7.1.1 - hexokinase

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DISEASE
TITLE OF PUBLICATION
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Acidosis
Computer simulation of energy metabolism in acidotic cardiac ischemia.
Metabolism of totally ischemic excised dog heart. II. Interpretation of a computer model.
[Changes in the activity and isoenzymic spectrum of skeletal muscle and brain hexokinase under organism adaptation to intensive physical exercise.]
Acute Kidney Injury
Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.
Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.
The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats.
Acute Lung Injury
Analysis of mRNA?lncRNA and mRNA?lncRNA-pathway co?expression networks based on WGCNA in developing pediatric sepsis.
Adenocarcinoma
Changes in glucose transport activities in mammary adenocarcinoma of dogs.
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells.
Expressions of hypoxia-inducible factor-1? and hexokinase-II in gastric adenocarcinoma: the impact on prognosis and correlation to clinicopathologic features.
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
High- and low-tumorigenic culture lines of rat uterine adenocarcinoma and their isozyme patterns of lactate dehydrogenase and hexokinase.
Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis.
Long non-coding RNA HOTAIR promotes cancer cell energy metabolism in pancreatic adenocarcinoma by upregulating hexokinase-2.
Mitochondrial hexokinase from differentiated and undifferentiated HT29 colon cancer cells: effect of some metabolites on the bound/soluble equilibrium.
Modification of the hexokinase activity in the red blood cells of subjects with differentiated adenocarcinoma.
Relationship between erythrocyte hexokinase in cancer patients and red cell age.
Study on ATP-generating system and related hexokinase activity in mitochondria isolated from undifferentiated or differentiated HT29 adenocarcinoma cells.
[18F]2-fluoro-2-deoxy-D-glucose incorporation by AGS gastric adenocarcinoma cells in vitro during response to epirubicin, cisplatin and 5-fluorouracil.
Adenocarcinoma of Lung
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
Adenoma
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms.
[Catalytic properties and isoenzyme composition of hexokinase in thyroid gland normal and neoplastic tissue]
Adenoma, Islet Cell
Alloxan and ninhydrin inhibition of hexokinase from pancreatic islets and tumoural insulin-secreting cells.
adenosine deaminase deficiency
Ultra-performance liquid chromatography-tandem mass spectrometry-based multiplex enzyme assay for six enzymes associated with hereditary hemolytic anemia.
Adrenocortical Adenoma
Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms.
Adrenocortical Carcinoma
Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms.
Alcohol Withdrawal Seizures
Hexokinase redistribution in vivo.
Alkalosis
[Redox processes in the retina and tunic tissues of the rat eye in experimental alkalosis]
Altitude Sickness
Overexpression of genes associated with hypoxia in cattle adapted to Trans Himalayan region of Ladakh.
Alzheimer Disease
Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease.
Altered hexokinase activity in skin cultured fibroblasts and leukocytes from Alzheimer's disease patients.
Changes in Na+,K(+)-ATPase, Ca2(+)-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease.
Decreased brain glucose metabolism in microvessels from patients with Alzheimer's disease.
Leukocyte hexokinase activity in aging and Alzheimer disease.
[Hexokinase in Alzheimer's disease]
Anaplasmosis
The effect of Anaplasma marginale on the glycolytic pathway in bovine erythrocytes.
Anemia
Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency.
Electrophoretic characterization and subcellular distribution of hexokinase isoenzymes in red blood cells of rabbits.
Glucose 6-phosphate dehydrogenase, hexokinase activities and ATP levels as a function of cell density in thalassemia and iron deficiency anemia.
Hexokinase deficiency anemia with dental and other anomalies: report of case.
Inhibitory effect of mannose on erythrocyte defense against oxidants.
Relationship between erythrocyte hexokinase in cancer patients and red cell age.
The relationship between red cell aging and enzyme activities in experimental animals.
[Activity of kidney tissue enzymes in phenylhydrazine anemia and post-transfusion polycythemia]
[Atrio-digital dysplasia with anemia, erythrocyte hexokinase deficiency and chromosome anomalies]
[Cytogenetic finding and etiology of Fanconi's anemia. A case of Fanconi's anemia without hexokinase deficiency]
[Hexokinase isoenzymes in normal erythrocytes of adults and newborns and in various hyperregenerative anemias]
[Leading criteria of reticulocyte maturation. 3. Behavior of hexokinase and glucokinase of red blood cells during a bleeding anemia of the rabbit]
Anemia, Aplastic
The pattern of reactivated fetal erythropoiesis in bone marrow disorders of childhood.
Anemia, Diamond-Blackfan
Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia.
The pattern of reactivated fetal erythropoiesis in bone marrow disorders of childhood.
Anemia, Hemolytic
A nonsense variant in the Hexokinase 1 gene (HK1) causing severe non-spherocytic haemolytic anaemia: genetic analysis exemplifies ambiguity due to multiple Isoforms.
Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia.
Allogeneic bone marrow transplantation for treatment of severe hemolytic anemia attributable to hexokinase deficiency.
Congenital nonspherocytic hemolytic anemia associated with an unusual erythrocyte hexokinase abnormality.
Congenital nonspherocytic hemolytic anemia with an unstable hexokinase variant.
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia.
Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency.
Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia.
Hemolytic anemia and hexokinase deficiency associated with malformations.
Hemolytic anemia with impaired hexokinase activity.
Hereditary nonspherocytic hemolytic anemia and hexokinase deficiency.
Hereditary nonspherocytic hemolytic anemia due to a new hexokinase variant with reduced stability.
Hexokinase "New Hyde Park": a low activity erythrocyte isozyme in a Chinese kindred.
Hexokinase deficiency in erythrocytes: a new variant in 5 members of a Finnish family.
Hexokinase mutations that produce nonspherocytic hemolytic anemia.
Hexokinase: gene structure and mutations.
HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia.
Homozygous intragenic deletion of type I hexokinase gene causes lethal hemolytic anemia of the affected fetus.
Human erythrocyte hexokinase deficiency. Characterization of a mutant enzyme with abnormal regulatory properties.
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Molecular bases of hexokinase deficiency.
Non-spherocytic haemolytic anaemia in mother and son associated with hexokinase deficiency.
Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia.
Novel pathogenic variant c.2714C>A (p. Thr905Lys) in the HK1 gene causing severe haemolytic anaemia with developmental delay in an Indian family.
[Hemolytic anemia caused by hexokinase deficiency]
[Hereditary nonspherocytic hemolytic anemia caused by a deficiency in erythrocytic hexokinase associated with glycogenosis of muscles]
[Hexokinase deficiency in hemolytic anemia]
Anemia, Hemolytic, Congenital
Congenital hemolytic anemia due to hexokinase deficiency.
Hereditary hemolytic anemia with hexokinase deficiency. Role of hexokinase in erythrocyte aging.
Inhibitory effect of mannose on erythrocyte defense against oxidants.
Anemia, Hemolytic, Congenital Nonspherocytic
Congenital nonspherocytic hemolytic anemia associated with an unusual erythrocyte hexokinase abnormality.
Congenital nonspherocytic hemolytic anemia with an unstable hexokinase variant.
Anemia, Hypochromic
A dual role of tobacco hexokinase 1 in primary metabolism and sugar sensing.
Anemia, Iron-Deficiency
Glucose 6-phosphate dehydrogenase, hexokinase activities and ATP levels as a function of cell density in thalassemia and iron deficiency anemia.
Arteriosclerosis
[Studies on arteriosclerosis and endangitis obliterans. VIII. Hexokinase and adenosine triphosphatase in skeletal muscles in peripheral vascular disorders.]
Arthritis, Rheumatoid
Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis.
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Increased hexokinase-2 as a novel biomarker for the diagnosis and correlating with disease severity in rheumatoid arthritis.
[Serum hexokinase isoenzymes in rheumatoid arthritis]
Astrocytoma
Effect of lonidamine on human malignant gliomas: biochemical studies.
The membrane-bound hexokinase as a potential marker for malignancy in human gliomas.
Ataxia
The double dealing of cyclin D1.
Atherosclerosis
Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for liver X receptors.
Atypical Squamous Cells of the Cervix
Protein degradation during yeast sporulation. Enzyme and cytochrome patterns.
Bile Duct Neoplasms
Analysis of the roles of glucose transporter 1 and hexokinase 2 in the metabolism of glucose by extrahepatic bile duct cancer cells.
Birth Injuries
[Hexokinase and aldolase activity in the healthy newborn, in asphyxia and in birth injuries]
Brain Diseases
Proton-dependent inhibition of yeast and brain hexokinases by aluminum in ATP preparations.
Brain Injuries
Hexokinase 2-dependent hyperglycolysis driving microglial activation contributes to ischemic brain injury.
Brain Neoplasms
Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.
Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure.
Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway.
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.
Homophilic anchorage of brain-hexokinase to mitochondria-porins revealed by specific-peptide antibody cross recognition.
Kinetic characterization of hexokinase isoenzymes from glioma cells: implications for FDG imaging of human brain tumors.
Oxidative metabolism and glycolysis in benign brain tumors.
Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment.
[Hexokinase activty in human brain tumors]
[Isoforms of human and animal tumor hexokinase]
Breast Diseases
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
Breast Neoplasms
17{beta}-Estradiol Augments 18F-FDG Uptake and Glycolysis of T47D Breast Cancer Cells via Membrane-Initiated Rapid PI3K-Akt Activation.
A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells.
Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis.
Anomeric specificity of hexokinase in rat, human, and murine tumor cells.
Biological characterisation of breast cancer by means of PET.
Bisabolane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense.
Changes in 2-fluoro-2-deoxy-D-glucose incorporation, hexokinase activity and lactate production by breast cancer cells responding to treatment with the anti-HER-2 antibody trastuzumab.
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells.
Comparison of glycolytic enzyme and isoenzyme activity in breast cancers and dysplasia.
Correction: PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.
Dissection of signaling pathways in fourteen breast cancer cell lines using reverse-phase protein lysate microarray.
Down-regulation of RIP1 by 2-deoxy-D-glucose sensitizes breast cancer cells to TRAIL-induced apoptosis.
Effect of the antitumor drug lonidamine on glucose metabolism of adriamycin-sensitive and -resistant human breast cancer cells.
Effects of curcumin on cancer cell mitochondrial function and potential monitoring with 18F-FDG uptake.
Elevated Hexokinase II Expression Confers Acquired Resistance to 4-Hydroxytamoxifen in Breast Cancer Cells.
Expression of hexokinase II and Glut-1 in untreated human breast cancer.
Gen-27, a newly synthesized flavonoid, inhibits glycolysis and induces cell apoptosis via suppression of hexokinase II in human breast cancer cells.
Glycolytic enzyme activities in breast cancer metastases.
Glycolytic enzymes in breast cancer, benign breast disease and normal breast tissue.
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma.
Hexokinase II in breast carcinoma: A potent prognostic factor associated with hypoxia-inducible factor-1? and Ki-67.
Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.
Hexokinase II is a prognostic factor associated with HIF-1? and Ki-67 in breast carcinoma. Immunohistochemistry for hexokinase II in the invasive edge of breast carcinoma.See also Sato-Tadano, A., et al.
Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells.
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
Impairment of HIF-1?-mediated metabolic adaption by NRF2-silencing in breast cancer cells.
Influence of resistance to 5-fluorouracil and tomudex on [18F]?FDG incorporation, glucose transport and hexokinase activity.
Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.
Kisspeptin 10 inhibits the Warburg effect in breast cancer through the Smad signaling pathway: both in vitro and in vivo.
Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast.
Nanosized Tamoxifen-Porphyrin-Glucose [TPG] Conjugate: Novel Selective Anti-Breast-Cancer Agent, Synthesis and In Vitro Evaluations.
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
Newcastle disease virus suppress glycolysis pathway and induce breast cancer cells death.
Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma.
Overexpression of ErbB2 renders breast cancer cells susceptible to 3-BrPA through the increased dissociation of hexokinase II from mitochondrial outer membrane.
PGC1? Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression.
PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Propranolol inhibits glucose metabolism and 18F-FDG uptake of breast cancer through posttranscriptional downregulation of hexokinase-2.
Response to trastuzumab by HER2 expressing breast tumour xenografts is accompanied by decreased Hexokinase II, glut1 and [18F]-FDG incorporation and changes in 31P-NMR-detectable phosphomonoesters.
Serum aldolase and hexokinase activities in breast carcinoma.
Serum glycolytic enzymes in breast carcinoma.
Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions.
Stunning and Its Effect on 3H-FDG Uptake and Key Gene Expression in Breast Cancer Cells Undergoing Chemotherapy.
The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway.
Tissue-Specific Warburg Effect in Breast Cancer and Cancer-Associated Adipose Tissue-Relationship between AMPK and Glycolysis.
Tumor 18F-FDG incorporation is enhanced by attenuation of P53 function in breast cancer cells in vitro.
Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines.
WD-3 inhibits the proliferation of breast cancer cells by regulating the glycolytic pathway.
[F]fluoro-2-deoxy-d-glucose incorporation by mcf-7 breast tumour cells in vitro is modulated by treatment with tamoxifen, Doxorubicin, and docetaxel: relationship to chemotherapy-induced changes in ATP content, hexokinase activity, and glucose transport.
[Knockdown of hexokinase 2 (HK2) inhibits breast cancer cell proliferation and reduces their resistance to fluorouracil].
Burkitt Lymphoma
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1.
Carcinogenesis
AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-?B, HIF1?, MMP2, and MMP9 upregulation.
An in situ study of bioenergetic properties of human colorectal cancer: the regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome.
c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.
Corrigendum: Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.
Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.
Evidence for heightened hexokinase II immunoexpression in hepatocyte dysplasia and hepatocellular carcinoma.
Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment.
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
Isozymic forms of some energy metabolism enzymes during oncovirus-induced cell transformation.
Long noncoding RNA KCNQ1OT1 promotes colorectal carcinogenesis by enhancing aerobic glycolysis via hexokinase-2.
Microcompartmentation of energy metabolism at the outer mitochondrial membrane: role in diabetes mellitus and other diseases.
MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer.
Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.
PGC1? Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression.
Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.
The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma.
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma]
[Change in cell membrane permeability, and composition and properties of hexokinase during induced carcinogenesis]
[CHANGES IN GLUCOKINASE AND HEXOKINASE CONTENT OF THE RAT LIVER AFTER FASTING, DURING CARCINOGENESIS AND IN PRIMARY AND TRANSPLANTED HEPATOMA.]
[Hexokinase activity in blood serum during carcinogenesis]
[Liver hexokinase isoenzymes in carcinogenesis]
Carcinoma
Carbohydrate metabolism in human renal clear cell carcinomas.
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression.
Clinical significance of serum lactate dehydrogenase, phosphohexose isomerase, aldolase and hexokinase in prostatic carcinoma.
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells.
Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia.
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma.
Diagnostic and prognostic significance of serum phosphohexose isomerase, aldolase and hexokinase in carcinoma cervix.
Differential glycolytic profile and Warburg effect in papillary thyroid carcinoma cell lines.
Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms.
Expression of type 2 hexokinase and mitochondria-related genes in gastric carcinoma tissues and cell lines.
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
Glucose 6-phosphate-dependent binding of hexokinase to membranes of ascites tumor cells.
Glycolysis-related protein expression in thyroid cancer.
Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma.
Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.
Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma.
Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment.
Hexokinase II in breast carcinoma: A potent prognostic factor associated with hypoxia-inducible factor-1? and Ki-67.
Hexokinase type II: a novel tumor-specific promoter for gene-targeted therapy differentially expressed and regulated in human cancer cells.
Hexokinase-II expression in untreated oral squamous cell carcinoma: comparison with FDG PET imaging.
Histochemical observations of hexokinase in leukoplakias and squamous cell carcinomas of oral cavity and maxillary sinus.
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response.
Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.
Interaction of cytotoxic antibiotic dactylarin with glycolytic thiol enzymes in Ehrlich ascites carcinoma cells.
Isoenzyme shift from glucokinase to hexokinase is not an early but a late event in hepatocarcinogenesis.
LncRNA loc285194 inhibits tumor growth of laryngeal squamous cell carcinoma cells by downregulating hexokinase 2.
Long Term Prognostic Implications of Expression of Glucose Transporter-1 and Hexokinase II in Patients with Stage I Uterine Leiomyosarcoma.
MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2.
miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma.
MiR-125b-5p suppressed the glycolysis of laryngeal squamous cell carcinoma by down-regulating hexokinase-2.
On the mechanism of glycolysis stimulation by mitochondria from Guérin epithelioma.
Physcion 8-O-?-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis.
Prognostic significance of synergistic hexokinase-2 and beta2-adrenergic receptor expression in human hepatocelluar carcinoma after curative resection.
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Retraction notice to "physcion 8-O-?-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis" [Biomed. Pharmacother. 104 (2018) 28-35].
Significance of serum phosphohexose isomerase, hexokinase and aldolase in carcinoma ovary.
Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp.
The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression.
The tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma.
Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma.
Warburg effect, hexokinase-II, and radioresistance of laryngeal carcinoma.
Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells.
[Cytochemical demonstration of the initial steps of glycolysis and hexokinase activity in Ehrlich carcinoma cells]
[Hexokinase formation in ascites cell carcinoma in mice.]
[Inhibition of Sirolimus on the growth of pancreatic carcinoma and its effect on the expression of glucose transporter and hexokinase ?].
[Maximum activity and substrate affinity of hexokinase in homogenates and in intact Ehrlich ascites carcinoma cells]
Carcinoma, Ehrlich Tumor
A variant of hexokinase isoenzymes detected in ascites tumor cells.
Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria.
Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
Inhibition of hexokinase and protein kinase activities of tumor cells by a chloromethyl ketone derivative of lactic acid.
Studies on the mode of action of RC4, a new anti-cancer agent containing ethyleneimino ring. I. Effects of RC4 and allied agents on glycolysis, respiration, hexokinase and phosphatase of Ehrlich ascites tumor cells and on choline-esterase of human blood.
The effect of glucosone on the proliferation and energy metabolism of in vitro grown Ehrlich ascites tumor cells.
[Distribution of hexokinase in Ehrlich ascites tumor cells]
[Studies on the soluble and particular hexokinase in Ehrlich ascites tumor cells]
Carcinoma, Hepatocellular
3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings.
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity.
Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis.
Adenylate kinase is a source of ATP for tumor mitochondrial hexokinase.
Alteration of enzyme function of the type II hexokinase C-terminal half on replacements of restricted regions by corresponding regions of glucokinase.
Altered metabolic states do not change the intracellular distribution of hexokinase in Zajdela hepatoma ascites cells.
Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2/STAT3 signaling.
An unusual high-Km hexokinase is expressed in the mhAT3F hepatoma cell line.
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.
Astragalin Reduces Hexokinase 2 through Increasing miR-125b to Inhibit the Proliferation of Hepatocellular Carcinoma Cells in Vitro and in Vivo.
Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
By blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma.
Carbonic anhydrase-IX inhibition enhances the efficacy of hexokinase II inhibitor for hepatocellular carcinoma in a murine model.
Caveolin enhances hepatocellular carcinoma cell metabolism, migration, and invasion in vitro via a hexokinase 2-dependent mechanism.
Changes in hexokinase properties during transformation and subsequent proliferation of liver cells.
Characteristics of mitochondria isolated by rate zonal centrifugation from normal liver and Novikoff hepatomas.
Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival.
Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2.
Clinical implication of glucose transport and metabolism evaluated by 18F-FDG PET in hepatocellular carcinoma.
Clinicopathological presentation of varying 18F-FDG uptake and expression of glucose transporter 1 and hexokinase II in cases of hepatocellular carcinoma and cholangiocellular carcinoma.
Detection of a progression-linked DNA restriction fragment in rat hepatoma cells probed with a hexokinase cDNA.
Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase.
Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.
Effect of growth in vivo and in vitro on phenotype of hexokinase isozymes in hepatoma cells.
Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma.
Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition.
Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines.
Evidence for heightened hexokinase II immunoexpression in hepatocyte dysplasia and hepatocellular carcinoma.
Evidence for multiple genes coding for the isozymes of hexokinase in the highly glycolytic AS-30D rat hepatoma.
Evidence that transcription of the hexokinase gene is increased in a rapidly growing rat hepatoma.
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.
Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase.
Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53.
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.
Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP.
Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression.
Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase.
Glucose utilization by tumor cells: a post-translational modification of mitochondrial hexokinase may play a regulatory role.
Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism.
Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.
Hexokinase activity and glycolytic capacity of plasma membranes of hepatomas.
Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma.
Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.
Hexokinase II in CD133+ and CD133- Hepatoma BEL-7402 Cells.
Hexokinase isozyme pattern in CCl(4)-injured rat liver.
Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC.
Hexokinase receptors: preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites.
Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy.
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma.
High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase.
Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression.
Identification of upstream stimulatory factor as transcriptional activator of the liver promoter of the glucokinase gene.
Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis.
Inihibition of Glycolysis by Using a Micro/Nano-Lipid Bromopyruvic Chitosan Carrier as a Promising Tool to Improve Treatment of Hepatocellular Carcinoma.
Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase.
LL95 monoclonal antibody mimics functional effects of ZP3 on mouse sperm: evidence that the antigen recognized is not hexokinase.
MicroRNA-34a inhibit hepatocellular carcinoma progression by repressing hexokinase-1.
Mitochondrial hexokinase of rat hepatoma cells in culture: solubilization and kinetic properties.
Modulating effect of Semecarpus anacardium Linn. nut extract on glucose metabolizing enzymes in aflatoxin B1-induced experimental hepatocellular carcinoma.
Modulatory Role of Shorea robusta Bark on Glucose-metabolizing Enzymes in Diethylnitrosamine Induced Hepatocellular Carcinoma in Rats.
Nucleotide sequence of the 5'-flanking region of the rat type II hexokinase gene.
Overexpression of microRNA-125b sensitizes human hepatocellular carcinoma cells to 5-fluorouracil through inhibition of glycolysis by targeting hexokinase II.
p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties.
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Prognostic significance of synergistic hexokinase-2 and beta2-adrenergic receptor expression in human hepatocelluar carcinoma after curative resection.
Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line.
Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.
Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130.
Retraction notice to "Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2/STAT3 signaling" [Biomed Pharmacother. 107 (2018) 243-253].
RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma.
STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cells.
Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp.
Studies on particle-bound hexokinase in rat ascites hepatoma cells.
Synthesis and targeting of hexokinase to mitochondria in hepatoma cells.
Targeting of hexokinase 1 to liver and hepatoma mitochondria.
Targets of 3-Bromopyruvate, a New, Energy Depleting, Anticancer Agent.
The antitumor effect and hepatotoxicity of a hexokinase II inhibitor 3-bromopyruvate: in vivo investigation of intraarterial administration in a rabbit VX2 hepatoma model.
The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells.
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells.
ZHX2 and ZHX3 repress cancer markers in normal hepatocytes.
[Activity and isoenzymatic spectrum of hexokinase and pyruvate kinase during carcinogenesis in the liver and in primary hepatoma]
[Activity of enzymes of glycolysis and gluconeogenesis in primary hepatomas induced by diethylnitrosamine]
[Activity of soluble and bound hexokinase in transplantable hepatomas of different degrees of malignancy, and in normal and regenerating mouse livers]
[Activity of the key glycolysis and respiration enzymes in the rat liver in chemical carcinogenesis]
[Biochemical characteristics determining the rates of tumour growth in the organism]
[Biochemical features of the liver of high and low cancer mouse strains and primary spontaneous hepatomas]
[Carbohydrate metabolism enzymatic activity and its alteration under the influence of thyroid hormone during tumor growth]
[CHANGES IN GLUCOKINASE AND HEXOKINASE CONTENT OF THE RAT LIVER AFTER FASTING, DURING CARCINOGENESIS AND IN PRIMARY AND TRANSPLANTED HEPATOMA.]
[Characteristics of hexosephosphate transformation regulation in Zajdela hepatoma and the liver of tumor-bearing rats]
[Differences in activity and intracellular localization of hexokinase between normal liver and hepatomas in the rat]
[Isoforms of human and animal tumor hexokinase]
[Liver hexokinase isoenzymes in carcinogenesis]
[Noradrenaline and glycogen content and the activity of several enzymes of carbohydrate metabolism in normal, embryonic, and partly denervated livers and in hepatomas of the rat]
[On hexokinase isozymes]
[Some characteristics of isoenzymic spectrum of hexokinase and glucose levels in hepatomas and liver of the host]
[Subcellular distribution of hexokinase in hepatoma and its electrophoretic properties]
[THE HEXOKINASE ACTIVITY IN HOMOGENATES OF NORMAL, REGENERATING AND PRECANCEROUS RAT LIVER AND IN PRIMARY AND TRANSPLANTED HEPATOMA.]
[THE HEXOKINASE ACTIVITY IN THE MITOCHONDRIA OF THE PRECANCEROUS RAT LIVER AND TRANSPLANTED DIETHYLNITROSAMINE HEPATOMA.]
[The role of hexokinase 2 in the metastasis of hepatocellular carcinoma cells].
Carcinoma, Medullary
Glycolysis-related protein expression in thyroid cancer.
Carcinoma, Non-Small-Cell Lung
Jolkinolide B inhibits glycolysis by downregulating hexokinase 2 expression through inactivating the Akt/mTOR pathway in non-small cell lung cancer cells.
miR-206 regulates non-small cell lung cancer cell aerobic glycolysis by targeting hexokinase 2.
Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer.
Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II.
Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
Carcinoma, Ovarian Epithelial
Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer.
Euxanthone inhibits glycolysis and triggers mitochondria-mediated apoptosis by targeting hexokinase 2 in epithelial ovarian cancer.
p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer.
Carcinoma, Pancreatic Ductal
The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
Carcinoma, Papillary
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Carcinoma, Renal Cell
Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma.
Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment.
Physcion 8-O-?-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis.
Retraction notice to "physcion 8-O-?-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis" [Biomed. Pharmacother. 104 (2018) 28-35].
The tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma.
Carcinoma, Squamous Cell
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression.
Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia.
Enzyme activities in human fetal and neoplastic tissues.
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma.
Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.
Histochemical observations of hexokinase in leukoplakias and squamous cell carcinomas of oral cavity and maxillary sinus.
HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma.
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma.
Cardiomegaly
Effects of beta 1- and beta 1 + beta 2-antagonists on training-induced myocardial hypertrophy and enzyme adaptation.
Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production.
Cardiomyopathies
Enhanced glycolytic metabolism contributes to cardiac dysfunction in polymicrobial sepsis.
Cataract
Hexokinase in x-ray cataract in rabbits.
Lens opacities in glycogenoses type I and III.
Levels of expression of hexokinase, aldose reductase and sorbitol dehydrogenase genes in lens of mouse and rat.
Mechanism of "hypoglycemic" cataract formation in the rat lens. I. The role of hexokinase instability.
Mechanism of "hypoglycemic" cataract formation in the rat lens. II. Further studies on the role of hexokinase instability.
The sorbitol pathway in the human lens: aldose reductase and polyol dehydrogenase.
[Study of the hexokinase activity of the crystallinelens in rabbits made diabetic by dithizone and the problem of diabetic cataract.]
Cell Transformation, Neoplastic
Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages.
Chagas Disease
A Mechanistic Probe into the Dual Inhibition of T. cruzi Glucokinase and Hexokinase in Chagas Disease Treatment - A Stone Killing Two Birds?
Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies.
Comparative study of enzymes in testes and ovaries from adult Dipetalogaster maximus (Uhler) and triatoma infestans (Klug) (Hemiptera: Reduviidae). correlation with fine structural organization.
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches.
Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase.
Cholangiocarcinoma
Clinicopathological presentation of varying 18F-FDG uptake and expression of glucose transporter 1 and hexokinase II in cases of hepatocellular carcinoma and cholangiocellular carcinoma.
Different glucose uptake and glycolytic mechanisms between hepatocellular carcinoma and intrahepatic mass-forming cholangiocarcinoma with increased (18)F-FDG uptake.
Expression of glucose transporters and hexokinase II in cholangiocellular carcinoma compared using [18F]-2-fluro-2-deoxy-D-glucose positron emission tomography.
Targeting hexokinase II as a possible therapy for cholangiocarcinoma.
Cholangitis
Novel Anti-Hexokinase 1 Antibodies Are Associated With Poor Prognosis in Patients With Primary Biliary Cholangitis.
Cholestasis
[Activity of carbohydrate metabolism enzyme activity in normal and pathologic parodontal tissues]
Chondroblastoma
False positive (18)F-FDG PET in an ischial chondroblastoma; an analysis of glucose transporter 1 and hexokinase II expression.
Chordoma
The nature of cytoplasmic vacuoles in chordoma cells. A correlative enzyme and electron microscopic histochemical study.
Choriocarcinoma
Enzymes of normal and malignant trophoblast: phosphoglucose isomerase, phosphoglucomutase, hexokinase, lactate dehydrogenase, and alkaline phosphatase.
Clonorchiasis
Advanced enzymology, expression profile and immune response of Clonorchis sinensis hexokinase show its application potential for prevention and control of clonorchiasis.
Colonic Neoplasms
A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells.
AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-?B, HIF1?, MMP2, and MMP9 upregulation.
Downregulation of the hexokinase II gene sensitizes human colon cancer cells to 5-fluorouracil.
Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells.
LncRNA-DANCR Interferes With miR-125b-5p/HK2 Axis to Desensitize Colon Cancer Cells to Cisplatin vis Activating Anaerobic Glycolysis.
Mechanisms related to [18F]fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice.
Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1? mediated signal pathway.
microRNA-143 down-regulates Hexokinase 2 in colon cancer cells.
MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.
Mitochondrial hexokinase from differentiated and undifferentiated HT29 colon cancer cells: effect of some metabolites on the bound/soluble equilibrium.
PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells.
Regulation of mitochondrial hexokinase in cultured HT 29 human cancer cells. An ultrastructural and biochemical study.
Silencing hexokinase II gene sensitizes human colon cancer cells to 5-fluorouracil.
Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo.
Study on ATP-generating system and related hexokinase activity in mitochondria isolated from undifferentiated or differentiated HT29 adenocarcinoma cells.
[Expression of hexokinase-II gene in human colon cancer cells and the therapeutic significance of inhibition thereof]
Colorectal Neoplasms
Colorectal tumor cells treated with 5-FU, oxaliplatin, irinotecan, and cetuximab exhibit changes in 18F-FDG incorporation corresponding to hexokinase activity and glucose transport.
Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1? in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.
Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.
Dioscin Inhibited Glycolysis and Induced Cell Apoptosis in Colorectal Cancer via Promoting c-myc Ubiquitination and Subsequent Hexokinase-2 Suppression.
Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer.
Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells.
Hexokinase 2 in colorectal cancer: a potent prognostic factor associated with glycolysis, proliferation and migration.
Long Non-Coding RNA C1QTNF1 Antisense RNA 1 Upregulates Hexokinase 2 by Sponging microRNA-484 to Promote the Malignancy of Colorectal Cancer.
MicroRNA-513a-3p regulates colorectal cancer cell metabolism via targeting hexokinase 2.
Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.
Penfluridol triggers mitochondrial-mediated apoptosis and suppresses glycolysis in colorectal cancer cells through down-regulating hexokinase-2.
Targeting hexokinase 2 increases the sensitivity of oxaliplatin by Twist1 in colorectal cancer.
The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.
The combined effect of dichloroacetate and 3-bromopyruvate on glucose metabolism in colorectal cancer cell line, HT-29; the mitochondrial pathway apoptosis.
The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression.
[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].
Congenital Hyperinsulinism
Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of ?-Cells.
Coronary Artery Disease
Molecular and Biochemical Parameters Related to Plasma Mannose Levels in Coronary Artery Disease Among Nondiabetic Patients.
Coronary Occlusion
Alterations in brain hexokinase activity associated with heart failure in rats.
COVID-19
Mitochondrial induced T cell apoptosis and aberrant myeloid metabolic programs define distinct immune cell subsets during acute and recovered SARS-CoV-2 infection.
Craniopharyngioma
Subtype-dependent difference of glucose transporter 1 and hexokinase II expression in craniopharyngioma: an immunohistochemical study.
Cystic Fibrosis
Increased activity of four glycolytic enzymes in cultured fibroblasts from cystic fibrosis patients.
Cysts
Dual-Stage Picolinic Acid-Derived Inhibitors of Toxoplasma gondii.
Isoenzyme and molecular characterization of Entamoeba histolytica and Entamoeba dispar isolates from symptomatic and asymptomatic subjects.
Some glucose metabolic enzymes in various fractions of sarcocysts of Sarcocystis fusiformis of buffalo (Bubalus bubalis).
[Distribution of zymodemes of Entamoeba histolytica from different areas of China]
Dehydration
A novel method for determining rate constants for dehydration of aldehyde hydrates.
Changes in leaf hexokinase activity and metabolite levels in response to drying in the desiccation-tolerant species Sporobolus stapfianus and Xerophyta viscosa.
Probing protein hydration and conformational states in solution.
Regional alterations in hexokinase activity within rat brain during dehydration and rehydration.
Volumetric and spectroscopic characterizations of glucose-hexokinase association.
Dementia
TIGAR inclusion pathology is specific for Lewy body diseases.
Diabetes Insipidus
Increased hexokinase activity in forebrain of water-deprived and diabetes insipidus rats.
Diabetes Mellitus
Activation of hexokinase by mild insulin dependent diabetes mellitus in rat erythrocytes.
Alterations in brain hexokinase activity associated with streptozotocin-induced diabetes mellitus in the rat.
Comparison of Accu Chek Inform II point-of-care test blood glucose meter with Hexokinase Plasma method for a diabetes mellitus population during surgery under general anesthesia.
Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression.
Functional consequences of naturally occurring variants of human hexokinase II.
Hexokinase Activity and Diabetes Mellitus.
Microcompartmentation of energy metabolism at the outer mitochondrial membrane: role in diabetes mellitus and other diseases.
Myocardial dysfunction in diabetic rats: influence of beta-adrenoceptor blockade (propranolol).
The hexokinase activity of skeletal muscle in diabetes mellitus.
[Activity of isoenzymes of hexokinase in erythrocytes of children with diabetes mellitus]
[Dynamics of erythrocyte hexokinase activity during glucose tolerance test in children with hereditary diabetes mellitus]
Diabetes Mellitus, Experimental
Changes in the activity of enzymes, participating in glycogen metabolism of alloxan diabetic rats.
THE REGULATION OF HEXOKINASE AND PHOSPHOFRUCTOKINASE ACTIVITY IN HEART MUSCLE. EFFECTS OF ALLOXAN DIABETES, GROWTH HORMONE, CORTISOL, AND ANOXIA.
[Activity of hexokinase and glucose-6-phosphate dehydrogenase in hemopoietic cells of the bone marrow in normal rabbits and after hydrocortisone administration during starvation and alloxan diabetes]
[Effect of trihydroxyoctadecadiene acids from Bryonia alba L. on the activity of glycogen metabolism enzymes in alloxan diabetes]
[Hexokinase activity of cardiac muscle in animals with alloxan diabetes]
[Ultrastructural manifestations of early metabolic disorders in the myocardium of dogs with alloxan diabetes]
Diabetes Mellitus, Type 1
The accuracy of the FreeStyle Navigator continuous glucose monitoring system in children with type 1 diabetes.
[CARBOHYDRATE METABOLISM IN TYPE 1 DIABETIC RATS UNDER THE CONDITIONS OF THE KIDNEY BEAN PODS AQUEOUS EXTRACT APPLICATION].
Diabetes Mellitus, Type 2
A novel (TA)n polymorphism in the hexokinase II gene: application to noninsulin-dependent diabetes mellitus in the Pima Indians.
A rare splice site mutation in the gene encoding glucokinase/hexokinase 4 in a patient with MODY type 2.
Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM.
Amino acid substitutions in hexokinase II among patients with NIDDM.
Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.
Assessing the potential of glucokinase activators in diabetes therapy.
Cellular mechanisms of insulin resistance in humans.
Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.
Human hexokinase II: localization of the polymorphic gene to chromosome 2.
Human hexokinase II: sequence and homology to other hexokinases.
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.
Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients.
Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.
Overexpression of hexokinase 2 reduces mitochondrial calcium overload in coronary endothelial cells of type 2 diabetic mice.
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.
Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.
Promoter variation in the liver glucokinase is a risk factor for non-insulin-dependent diabetes mellitus.
Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase.
Reduced expression of hexokinase II in insulin-resistant diabetes.
Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.
Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes.
Structure of the human hexokinase II gene.
The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM.
Type 2 diabetes differentially affects the substrate saturation kinetic attributes of erythrocyte hexokinase and phosphofructokinase.
Use of a reflectance photometer as a diabetes mellitus screening tool under field conditions.
Variant sequences of the Hexokinase II gene in familial NIDDM.
[Swiss journey through the clinical and genetic characteristics of diabetes in young patients]
Diabetes, Gestational
Hexokinase Domain Containing 1 (HKDC1) Gene Variants and their Association with Gestational Diabetes Mellitus in a South Indian Population.
Replication of previous genome-wide association studies of HKDC1, BACE2, SLC16A11 and TMEM163 SNPs in a gestational diabetes mellitus case-control sample from Han Chinese population.
The impact of differences in plasma glucose between glucose oxidase and hexokinase methods on estimated gestational diabetes mellitus prevalence.
Diabetic Nephropathies
High glucose induces type 1 hexokinase gene expression in isolated glomeruli of diabetic rats and in mesangial cells.
Diabetic Retinopathy
Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection.
MicroRNA-384-3p inhibits retinal neovascularization through targeting hexokinase 2 in mice with diabetic retinopathy.
Dysentery, Amebic
[Distribution of zymodemes of Entamoeba histolytica from different areas of China]
Encephalomyelitis, Autoimmune, Experimental
[Hexokinase and lactate dehydrogenase activity and isoenzymatic makeup of the soluble fraction of dissimilarly functioning rabbit muscles normally and in experimental allergic encephalomyelitis]
Endometrial Neoplasms
Knockdown of long non-coding RNA small nucleolar RNA host gene 9 or hexokinase 2 both suppress endometrial cancer cell proliferation and glycolysis.
Therapeutic potential of riboflavin, niacin and ascorbic Acid on carbohydrate metabolizing enzymes in secondary endometrial carcinoma bearing rats.
Ependymoma
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Epilepsy
Kinetic properties of hexokinase in resected temporal lobes of patients with drug-resistant epilepsy.
Esophageal Neoplasms
Hexokinase isoenzymes in the diagnosis of gastric and esophageal neoplasms.
Relationship between glucose transporter, hexokinase and FDG-PET in esophageal cancer.
[Analysis of glucose metabolism in patients with esophageal cancer by PET: estimation of hexokinase activity in the tumor and usefulness for clinical assessment using 18F-fluorodeoxyglucose]
Essential Hypertension
Nucleotide(-258) G-to-A transition variant of the liver glucokinase gene is associated with essential hypertension.
Fanconi Anemia
Red blood cell hexokinase in Fanconi's anemia.
[Cytogenetic finding and etiology of Fanconi's anemia. A case of Fanconi's anemia without hexokinase deficiency]
Fatty Liver
PPAR? contributes to PKM2 and HK2 expression in fatty liver.
Fibroadenoma
Relative value of oestrogen receptor assay, lactoferrin content, and glucose-6-phosphate dehydrogenase activity as prognostic indicators in primary breast cancer.
Fibrocystic Breast Disease
Comparison of glycolytic enzyme and isoenzyme activity in breast cancers and dysplasia.
Foot-and-Mouth Disease
Hexokinase activity as marker to assess time of harvest of foot-and-mouth disease virus in BHK(21) Cl(13) cell cultures.
Gastritis, Atrophic
[Hexokinase in gastric mucosa in patients with atrophic gastritis]
Giant Cell Tumor of Bone
Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT.
Giant Cell Tumors
Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT.
Glioblastoma
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.
High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss.
HOTAIR/miR-125 axis-mediated Hexokinase 2 expression promotes chemoresistance in human glioblastoma.
Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells.
Lonidamine in malignant brain tumors.
miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells.
Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment.
Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy.
SIRT6 regulated nucleosomal occupancy affects Hexokinase 2 expression.
Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma.
Xanthohumol suppresses glioblastoma via modulation of Hexokinase 2 -mediated glycolysis.
[Targeting the gene of glucose metabolism for the treatment of advanced gliomas]
Glioma
Activities of glycolytic enzymes in rapidly proliferating and differentiated C6 glioma cells.
Connexin 30 mediated rewiring of glucose metabolism in rat C6 xenograft and grades of glioma.
Determination of the deoxyglucose and glucose phosphorylation ratio and the lumped constant in rat brain and a transplantable rat glioma.
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme.
Effect of Naringenin on metabolic markers, lipid profile and expression of GFAP in C6 glioma cells implanted rat's brain.
Enzymes of glucose metabolism in cultured human gliomas: neoplasia is accompanied by altered hexokinase, phosphofructokinase, and glucose-6-phosphate dehydrogenase levels.
Enzymes related to energy metabolism in human gliomas.
Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure.
Glucose consumption and rate constants for 18F-fluorodeoxyglucose in human gliomas.
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Glycolytic profile in normal brain tissue and gliomas determined by a micro-method analysis.
Gomisin J inhibits the glioma progression by inducing apoptosis and reducing HKII-regulated glycolysis.
Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway.
Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells.
Hexokinase in cultured gliomas.
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production.
High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss.
HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell.
Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line.
Kinetic characterization of hexokinase isoenzymes from glioma cells: implications for FDG imaging of human brain tumors.
Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria.
LncRNA ZFAS1/miR-1271-5p/HK2 Promotes Glioma Development Through Regulating Proliferation, Migration, Invasion and Apoptosis.
Lonidamine in malignant brain tumors.
Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells.
miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells.
Mitochondria-bound hexokinase as target for therapy of malignant gliomas.
Modulation of glycolysis in neuroepithelial tumors.
Molecular imaging of gliomas.
No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma.
Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1?.
PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.
Phosphorylation of pyruvate kinase and glycolytic metabolism in three human glioma cell lines.
Rapamycin inhibits human glioma cell proliferation through down-regulating mammalian target of rapamycin pathway and up-regulating microRNA-143.
Rat C6 glioma cell growth is related to glucose transport and metabolism.
Regulation of hexokinase in cultured gliomas.
Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis.
The increase in gap junctional communication decreases the rate of glucose uptake in C6 glioma cells by releasing hexokinase from mitochondria.
The membrane-bound hexokinase as a potential marker for malignancy in human gliomas.
TNF? driven HIF-1?-hexokinase II axis regulates MHC-I cluster stability through actin cytoskeleton.
XBP1 silencing decreases glioma cell viability and glycolysis possibly by inhibiting HK2 expression.
Gliosarcoma
Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.
Glucose Intolerance
Control of liver glucokinase activity: A potential new target for incretin hormones?
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
A simple screening procedure for adenylate kinase, hexokinase and glucose-6-phosphate dehydrogenase deficiencies.
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
Role of hexokinase in the regulation of erythrocyte hexose monophosphate pathway under oxidative stress.
Glucosephosphate Dehydrogenase Deficiency
A simple screening procedure for adenylate kinase, hexokinase and glucose-6-phosphate dehydrogenase deficiencies.
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
Role of hexokinase in the regulation of erythrocyte hexose monophosphate pathway under oxidative stress.
Glycogen Storage Disease
[Hereditary nonspherocytic hemolytic anemia caused by a deficiency in erythrocytic hexokinase associated with glycogenosis of muscles]
Glycosuria
Accuracy and influence of ascorbic acid on glucose-test with urine dip sticks in prenatal care.
Granuloma
Insulin-like effect of sulfhydryl inhibitor on hexokinase isoenzyme of rat granuloma tissue in vitro and the opposite effect of sulfhydryl compound.
Graves Disease
Metabolism of glucose and glutamine in lymphocytes from Graves' hyperthyroid patients: influence of methimazole treatment.
Hamartoma
mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.
Heart Diseases
Mitochondrial hexokinase and cardioprotection of the intact heart.
Heart Failure
Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart.
Alterations in brain hexokinase activity associated with heart failure in rats.
Metabolic markers of myocardium insulin resistance in dogs with heart failure.
Hemoglobinopathies
Erythrocyte hexokinase isoenzyme patterns in hereditary hemoglobinopathies.
Hepatitis
Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-induced hepatocellular carcinoma.
Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.
[Hexokinase acitivity of blood serum of children with viral hepatitis]
[Phosphoglucomutase and hexokinase activities of various organs (liver, brain, kidney, myocardium) in the course of experimental MHV-3 hepatitis virus.]
Hepatitis B
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis C
Activity of hexokinase is increased by its interaction with hepatitis C virus protein NS5A.
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis, Alcoholic
Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.
Hepatitis, Autoimmune
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis, Chronic
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Hepatoblastoma
Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma.
Hereditary Sensory and Motor Neuropathy
A mutation in an alternative untranslated exon of hexokinase 1 associated with Hereditary Motor and Sensory Neuropathy - Russe (HMSNR).
Herpes Simplex
Hexokinase II gene transfer protects against neurodegeneration in the rotenone and MPTP mouse models of Parkinson's disease.
hexokinase deficiency
Allogeneic bone marrow transplantation for treatment of severe hemolytic anemia attributable to hexokinase deficiency.
Congenital hemolytic anemia due to hexokinase deficiency.
Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency.
First mutation in the red blood cell-specific promoter of hexokinase combined with a novel missense mutation causes hexokinase deficiency and mild chronic hemolysis.
Frequency of glucose-6-phosphate dehydrogenase, pyruvate kinase and hexokinase deficiency in the Saudi population.
Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia.
Glucose metabolism in fibroblasts from patients with erythrocyte hexokinase deficiency.
Hemolytic anemia and hexokinase deficiency associated with malformations.
Hereditary hemolytic anemia with hexokinase deficiency. Role of hexokinase in erythrocyte aging.
Hereditary nonspherocytic hemolytic anemia and hexokinase deficiency.
Hereditary nonspherocytic hemolytic anemia due to a new hexokinase variant with reduced stability.
Hexokinase "New Hyde Park": a low activity erythrocyte isozyme in a Chinese kindred.
Hexokinase deficiency anemia with dental and other anomalies: report of case.
Hexokinase deficiency in erythrocytes: a new variant in 5 members of a Finnish family.
Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
Hexokinase mutations that produce nonspherocytic hemolytic anemia.
HK Utrecht: missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia.
Human erythrocyte hexokinase deficiency. Characterization of a mutant enzyme with abnormal regulatory properties.
Human erythrocyte hexokinase deficiency: a new variant with abnormal kinetic properties.
Human red blood cell loading with hexokinase-inactivating antibodies. An in vitro model for enzyme deficiencies.
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Molecular bases of hexokinase deficiency.
Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1.
Non-spherocytic haemolytic anaemia in mother and son associated with hexokinase deficiency.
Novel pathogenic variant c.2714C>A (p. Thr905Lys) in the HK1 gene causing severe haemolytic anaemia with developmental delay in an Indian family.
Platelet functions and energy metabolism in a patient with hexokinase deficiency.
Proteomic and functional consequences of hexokinase deficiency in glucose-repressible Kluyveromyces lactis.
Red blood cell loading with hexokinase and hexokinase-inactivating antibodies. A new strategy for studying the role of enzymes in red cell metabolism and removal.
Role of hexokinase in the regulation of erythrocyte hexose monophosphate pathway under oxidative stress.
Role of hexokinase in the regulation of glucose metabolism in human erythrocytes.
[Atrio-digital dysplasia with anemia, erythrocyte hexokinase deficiency and chromosome anomalies]
[Cytogenetic finding and etiology of Fanconi's anemia. A case of Fanconi's anemia without hexokinase deficiency]
[Hemolytic anemia caused by hexokinase deficiency]
[Hexokinase deficiency in blood cells in a group of kin with familial panmyelopathy (Fanconi type)]
[Hexokinase deficiency in hemolytic anemia]
[Hexokinase deficiency of erythrocytes. Familial study of a case of primary isolated deficiency and ancassociated case with glucose-6 phosphate dehydrogenase deficiency]
Hodgkin Disease
Relationship between FDG uptake and expressions of glucose transporter type 1, type 3, and hexokinase-II in Reed-Sternberg cells of Hodgkin lymphoma.
Hookworm Infections
Biochemical and histopathological alterations in golden hamster during infection with Ancylostoma ceylanicum.
Hyperglycemia
A glucokinase-like enzyme carries out glucose phosphorylation in capillaries of normal and spontaneously hyperglycemic rabbits.
Aldose reductase and its inhibition in the control of diabetic complications.
Analysis of glucose metabolism in diabetic rat retinas.
Antihyperglycemic and antilipidperoxidative effects ofTephrosia purpurea seed extract in streptozotocin induced diabetic rats.
Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age.
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Effects of tephrosia purpurea aqueous seed extract on blood glucose and antioxidant enzyme activities in streptozotocin induced diabetic rats.
Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury.
Glucagon-like peptide-1 decreases intracerebral glucose content by activating hexokinase and changing glucose clearance during hyperglycemia.
Glucokinase expression is regulated by glucose through O-GlcNAc glycosylation.
Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.
Glucose catabolic gene mRNA levels in skeletal muscle exhibit non-coordinate expression in hyperglycemic mice.
Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia-Reperfusion Injury.
Hyperglycemia induces accumulation of glucose in human skeletal muscle.
In vitro inhibition of human erythrocyte hexokinase by various hyperglycemic drugs.
Increased hexokinase activity in fetuses of rats developed under maternal hyperglycemia.
Kinetic behaviour of liver glucokinase in diabetes. II. Possible role of non-enzymatic protein glycation.
Neonatal seizures in monkeys and rabbits: brain glucose depletion in the face of normoglycemia, prevention by glucose loads.
Pancreatectomy in a teleost fish, Anguilla rostrata (American eel).
Potential use of aldose reductase inhibitors to prevent diabetic complications.
Quercetin modulates hyperglycemia by improving the pancreatic antioxidant status and enzymes activities linked with glucose metabolism in type 2 diabetes model of rats: In silico studies of molecular interaction of quercetin with hexokinase and catalase.
Rabbit lens and retina phosphorylate glucose through a glucokinase-like enzyme: study in normal and spontaneously hyperglycemic animals.
Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy.
Statistical comparison of blood glucose as determined by several test-strip procedures and by a hexokinase procedure.
The effects of hyperinsulinemia and hyperglycemia on GLUT4 and hexokinase II mRNA and protein in rat skeletal muscle and adipose tissue.
Transgenic overexpression of hexokinase II in skeletal muscle does not increase glucose disposal in wild-type or Glut1-overexpressing mice.
Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomized rats.
[Liver metabolism during massive hemorrhage and subsequent blood transfusion]
[Peculiarities of carbohydrate metabolism in rabbits following prolonged immunization with viral antigens]
Hyperinsulinism
beta-cell stimulus - secretion coupling defects in rodent models of obesity.
Control of liver glucokinase activity: A potential new target for incretin hormones?
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo.
Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II.
Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.
Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle.
The effects of hyperinsulinemia and hyperglycemia on GLUT4 and hexokinase II mRNA and protein in rat skeletal muscle and adipose tissue.
Hyperlipoproteinemias
Adaptation of red cell enzymes and intermediates in metabolic disorders.
Hypersensitivity
Changes induced by sucrose administration on glucose metabolism in pancreatic islets in normal hamsters.
Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomized rats.
Hypertension
Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure?
Metabolic alterations in discrete regions of the rat brain during development of spontaneous hypertension.
miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension.
[Endocrine-metabolic relations in rats with genetic arterial hypertension]
Hyperthyroidism
Changes in hexokinase and glucose-6-phosphate dehydrogenase in red cells during hypo and hyperthyroidism.
Effect of hypo- and hyperthyroidism on hexokinase in the developing cerebellum of the rat.
Effect of hypo- and hyperthyroidism on the function and metabolism of macrophages in rats.
Effect of thyroid hormones on the glycolytic enzyme activity in brain areas of the rat.
Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat.
Increased acylphosphatase levels in erythrocytes from hyperthyroid patients.
Investigation of red blood cell carbonic anhydrase, glucose 6-phosphate dehydrogenase, hexokinase enzyme activities, and zinc concentration in patients with hyperthyroid diseases.
Specific effect of thyroid hormone on testicular enzymes involved in carbohydrate metabolism. II. Hyperthyroidism.
The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats.
[Effect of thyroxine on oxidative enzymatic activity in the rat aorta]
[Intraerythrocytic enzyme activities in euthyroid subjects and hyperthyroid patients before treatment and following stabilization of metabolism using radioiodine therapy]
Hypertriglyceridemia
Control of liver glucokinase activity: A potential new target for incretin hormones?
Hypertrophy, Left Ventricular
Left ventricular enzyme activities of the energy-supplying metabolism in Goldblatt-II rats.
Hypervitaminosis A
Early effects of vitamin A toxicity on hepatic glycolysis in rat.
Hypoglycemia
Brain glucosamine boosts protective glucoprivic feeding.
Changes in hexokinase isoenzymes in regions of rat brain during insulin-induced hypoglycemia.
Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens.
Clinical utility and accuracy of a blood glucose meter for the detection of neonatal hypoglycemia.
Computational prediction and experimental validation of the activator function of C2-?-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone on pancreatic and hepatic hexokinase.
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Effect of diabetes and insulin-induced hypoglycemia on hexokinase and glucose-6-phosphate dehydrogenase in red blood cells.
False paraprotein-induced hypoglycemia in the measurement of glucose by the hexokinase method.
How accurate is glucose analysis in the presence of multiple interfering substances in the neonate? (glucose analysis and interfering substances).
Hypoglycemia and embryonic heart development.
Lens opacities in glycogenoses type I and III.
Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms.
Statistical comparison of blood glucose as determined by several test-strip procedures and by a hexokinase procedure.
SUMOylation of Pancreatic Glucokinase Regulates Its Cellular Stability and Activity.
Hypokinesia
[Glycogen level and activity of carbohydrate metabolism enzymes in the liver of rats during the readaptation period after a 20-day hypokinesia]
Hypothyroidism
Effect of hypo- and hyperthyroidism on hexokinase in the developing cerebellum of the rat.
Effect of primary congenital hypothyroidism upon expression of genes mediating murine brain glucose uptake.
Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism.
The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats.
Hypoxia, Brain
[Effect of hypoxia on carbohydrate metabolism in scorpion tissues]
Infections
A Mechanistic Probe into the Dual Inhibition of T. cruzi Glucokinase and Hexokinase in Chagas Disease Treatment - A Stone Killing Two Birds?
ARGONAUTE 2 increases rice susceptibility to rice black-streaked dwarf virus infection by epigenetically regulating HEXOKINASE 1 expression.
cAMP Receptor Protein of Salmonella enterica Serovar Typhimurium Modulate Glycolysis in Macrophages to Induce Cell Apoptosis.
Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.
Dicer regulates Nosema ceranae proliferation in honey bees.
Does Entamoeba histolytica cause irritable bowel syndrome?
Effects of Salmonella enterica serovar typhimurium sseK1 on macrophage inflammation-related cytokines and glycolysis.
Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein.
Human metapneumovirus infection of airway epithelial cells is associated with changes in core metabolic pathways.
Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity.
Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures.
Regulation of autophagy, glucose uptake, and glycolysis under dengue virus infection.
Schistosoma mansoni hexokinase: cDNA cloning and immunogenicity studies.
Susceptibility of Biomphalaria alexandrina to infection with Schistosoma mansoni: correlation with the activity of certain glycolytic enzymes.
Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1.
[Difference in the inactivation of hexokinase activity in wheat leaves following infection with Puccinia graminis tritici]
Infertility
Quality and safety of parenteral nutrition for newborn and preterm infants as an on-ward preparation.
Infertility, Male
Deficiency of rice hexokinase HXK5 impairs synthesis and utilization of starch in pollen grains and causes male sterility.
Pentatricopeptide-repeat family protein RF6 functions with hexokinase 6 to rescue rice cytoplasmic male sterility.
Insulin Resistance
Abnormal regulation of hexokinase in insulin-resistant skeletal muscle.
Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.
Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.
Allosteric regulation of glycogen synthase and hexokinase by glucosamine-6-phosphate during glucosamine-induced insulin resistance in skeletal muscle and heart.
Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142-->His substitution.
Cellular mechanisms of insulin resistance in humans.
Chebulagic acid attenuates HFD/Streptozotocin induced impaired glucose metabolism and insulin resistance via up regulations of PPAR ? and GLUT 4 in type 2 diabetic rats.
Comparative effects of single-mode vs. duration-matched concurrent exercise training on body composition, low-grade inflammation, and glucose regulation in sedentary, overweight, middle-aged men.
Defect of an early event of glucose metabolism in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a non-insulin-dependent diabetes mellitus (NIDDM) model.
Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression.
Dietary energy source and physical conditioning affect insulin sensitivity and skeletal muscle glucose metabolism in horses.
Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans.
Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle.
Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism.
Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids
Effects of short-term training on insulin sensitivity and skeletal muscle glucose metabolism in standardbred horses.
Endotoxin-induced alterations in glucose transport in isolated adipocytes.
Functional consequences of naturally occurring variants of human hexokinase II.
GLUT4 and Glycogen Synthase Are Key Players in Bed Rest-Induced Insulin Resistance.
Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice.
Hexokinase II activity and messenger ribonucleic acid abundance in adipose tissue and skeletal muscle during pregnancy and lactation in rats.
Human hexokinase II: sequence and homology to other hexokinases.
Hypoglycemic effects and modulation of gut microbiota of diabetic mice by saponin from Polygonatum sibiricum.
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.
Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice.
Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.
Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy.
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.
Interaction of physical activity and diet: implications for insulin-glucose dynamics.
Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM.
Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24-48?h after exercise in young and old humans.
Mitigating Perspectives of Asiatic acid in the Renal derangements of Streptozotocin-Nicotinamide induced Diabetic Rats.
Molecular and Metabolic Markers of Fructose Induced Hepatic Insulin Resistance in Developing and Adult Rats are Distinct and Aegle marmelos is an Effective Modulator.
Muscle fiber composition and capillarization in relation to metabolic alterations in hypertensive men.
Overexpression of PGC-1? improves insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes.
Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus.
Phosphorylation of hexokinase in insulin resistance.
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.
Regulation of liver glucokinase activity in rats with fructose-induced insulin resistance and impaired glucose and lipid metabolism.
Structure of the human hexokinase II gene.
Studies of the impact of a liver glucokinase promoter variant on glucose tolerance and insulin sensitivity index.
The insulin resistance is reversed by exogenous 3,5,3'triiodothyronine in type 2 diabetic Goto-Kakizaki rats by an inflammatory-independent pathway.
The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.
Transgenic overexpression of hexokinase II in skeletal muscle does not increase glucose disposal in wild-type or Glut1-overexpressing mice.
Insulinoma
Characteristics of glucokinase of the Kirkman insulinoma.
Evaluation of the expression of hexokinase 1, glucokinase, and insulin by canine insulinoma cells maintained in short-term culture.
Hexokinase isoenzymes of RIN-m5F insulinoma cells. Expression of glucokinase gene in insulin-producing cells.
Identification and significance of glucokinase in transplantable insulinomas.
Liver-specific enhancer of the glucokinase gene.
Porin proteins in mitochondria from rat pancreatic islet cells and white adipocytes: identification and regulation of hexokinase binding by the sulfonylurea glimepiride.
Intervertebral Disc Degeneration
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Intracranial Embolism
Naftidrofuryl oxalate improves impaired brain glucose metabolism after microsphere-induced cerebral embolism in rats.
Iron Deficiencies
Iron deficiency attenuates protein synthesis stimulated by branched-chain amino acids and insulin in myotubes.
Irritable Bowel Syndrome
Isoenzyme and molecular characterization of Entamoeba histolytica and Entamoeba dispar isolates from symptomatic and asymptomatic subjects.
Ischemic Stroke
Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: Therapeutical effects of kaempferol.
Keratosis
A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses.
Ketosis
Effect of prenatally-induced and postnatally-maintained ketosis on beta-hydroxybutyrate dehydrogenase and hexokinase levels in the developing rat brain.
Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis.
Klatskin Tumor
PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma.
Laryngeal Neoplasms
INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.
Leiomyoma
Activities in leiomyomas and myometrium of enzymes involved in energy metabolism.
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Mitochondrial mutations in cancer.
[Tumorous origin of the hexokinase in human biological fluids]
Leiomyosarcoma
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Long Term Prognostic Implications of Expression of Glucose Transporter-1 and Hexokinase II in Patients with Stage I Uterine Leiomyosarcoma.
Leishmaniasis
Expression of Hexokinase in the Proteome Profile of Leishmania major and Crithidia
Leishmaniasis, Cutaneous
Development of Assays Using Hexokinase and Phosphoglucomutase Gene Sequences That Distinguish Strains of Leishmania tropica from Different Zymodemes and Microsatellite Clusters and Their Application to Palestinian Foci of Cutaneous Leishmaniasis.
Leukemia
2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner.
ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition.
Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis.
Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy.
Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.
[Determination of hexokinase activity in the blood serum in leukemias]
[On hexokinase activity in the blood serum of children with leukemia]
Leukemia, B-Cell
Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Isozyme distribution of hexokinase, phosphofructokinase and pyruvate kinase in lymphocytes from patients with chronic lymphocytic leukemia.
Leukemia, Lymphoid
Anomeric specificity of hexokinase in rat, human, and murine tumor cells.
Antitumor agents. XXXV: Effects of brusatol, bruceoside A, and bruceantin on P-388 lymphocytic leukemia cell respiration.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Overexpression of miR-202 re-sensitizes imatinib resistant chronic myeloid leukemia cells through targeting Hexokinase 2 (HK2).
Leukemia, Myeloid
Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2.
Leukoplakia
Histochemical observations of hexokinase in leukoplakias and squamous cell carcinomas of oral cavity and maxillary sinus.
Liver Cirrhosis
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Liver Cirrhosis, Biliary
Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis.
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Novel Anti-Hexokinase 1 Antibodies Are Associated With Poor Prognosis in Patients With Primary Biliary Cholangitis.
Liver Diseases
Hepatic hexokinase isozyme in liver diseases.
Hepatic HKDC1 Expression Contributes to Liver Metabolism.
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Liver Diseases, Alcoholic
Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.
Liver Neoplasms
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity.
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase.
Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer.
miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer.
The combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells.
[Aldolase and hexokinase in liver cancer cells]
[Mechanism of the anticancer action of selenium--influence on glycolysis and its key enzyme]
Liver Neoplasms, Experimental
Absence of hexokinase activity in plasma membranes of Morris hepatoma 5123 t.c.
Amino acid sequence homology between yeast hexokinases and rat hexokinase C.
Hexokinase isoenzymes from the Novikoff hepatoma. Purification, kinetic and structural characterization, with emphasis on hexokinase C.
Hexokinase isozyme patterns of experimental hepatomas of rats.
Microheterogeneity of cytosolic and membrane-bound hexokinase II in Morris hepatoma 3924A.
Presence of fast moving type IV hexokinase isozyme in Morris hepatoma.
Lung Diseases
[Blood hexokinase activity in lung diseases]
Lung Neoplasms
A causal link from ALK to hexokinase II overexpression and hyperactive glycolysis in EML4-ALK-positive lung cancer.
Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.
Differentiation of histological subtypes in lung cancer with 18F-FDG-PET 3-point imaging and kinetic analysis.
Down-regulation of miR-214 inhibits proliferation and glycolysis in non-small-cell lung cancer cells via down-regulating the expression of hexokinase 2 and pyruvate kinase isozyme M2.
Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients.
Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.
Jolkinolide B inhibits glycolysis by downregulating hexokinase 2 expression through inactivating the Akt/mTOR pathway in non-small cell lung cancer cells.
miR-206 regulates non-small cell lung cancer cell aerobic glycolysis by targeting hexokinase 2.
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer.
Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II.
Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer.
Radiogenomic Analysis Demonstrates Associations between (18)F-Fluoro-2-Deoxyglucose PET, Prognosis, and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.
Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2.
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
[Prognostic significance of the hexokinase test in patients with lung cancer]
Lymphatic Metastasis
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
Lymphoma
Expression of hypoxia-inducible factor 1?, glucose transporter 1, and hexokinase 2 in primary central nervous system lymphoma and the correlation with the biological behaviors.
Expressions of glucose transporter Types 1 and 3 and hexokinase-II in diffuse large B-cell lymphoma and other B-cell non-Hodgkin's lymphomas.
Glycolytic enzyme hexokinase II is a putative therapeutic target in B-cell malignant lymphoma.
HKDC1 C-terminal based peptides inhibit extranodal natural killer/T-cell lymphoma by modulation of mitochondrial function and EBV suppression.
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
Icaritin inhibits glioblastoma cell viability and glycolysis by blocking the IL-6/Stat3 pathway.
Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism.
The double dealing of cyclin D1.
Lymphoma, B-Cell
3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis.
Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy.
Expressions of glucose transporter Types 1 and 3 and hexokinase-II in diffuse large B-cell lymphoma and other B-cell non-Hodgkin's lymphomas.
Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics.
Lymphoma, Large B-Cell, Diffuse
Expressions of glucose transporter Types 1 and 3 and hexokinase-II in diffuse large B-cell lymphoma and other B-cell non-Hodgkin's lymphomas.
Lymphoma, Mantle-Cell
The double dealing of cyclin D1.
Lymphoma, Non-Hodgkin
A comparison of the effect of glucocorticoids on glucose uptake and hexokinase activity in lymphosarcoma P1798.
Malaria
Molecular analysis of Plasmodium falciparum hexokinase.
Purification and characterisation of the hexokinase of Plasmodium berghei, a murine malaria parasite.
Malnutrition
Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model.
Evidence for liver energy metabolism programming in offspring subjected to intrauterine undernutrition during midgestation.
Maternal undernutrition induces the expression of hypoxia-related genes in the fetal brain.
Medulloblastoma
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation.
Melanoma
Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model.
Biologic correlation between glucose transporters, hexokinase-II, Ki-67 and FDG uptake in malignant melanoma.
Ca2+-induced changes in energy metabolism and viability of melanoma cells.
Characterization of glycolysis-related gene expression in malignant melanoma.
Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells.
Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells.
Factors influencing [F-18] 2-fluoro-2-deoxy-D-glucose (F-18 FDG) uptake in melanoma cells: the role of proliferation rate, viability, glucose transporter expression and hexokinase activity.
Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma.
MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells.
Metabolic characterization of three hamster melanoma variants.
Variability in glucose transporter-1 levels and hexokinase activity in human melanoma.
Melanoma, Amelanotic
Metabolic characterization of three hamster melanoma variants.
Melanoma, Experimental
Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells.
Lithium detaches hexokinase from mitochondria and inhibits proliferation of B16 melanoma cells.
Metabolic Diseases
An HPLC method for the determination of adenosine diphosphate: An important marker of hexokinase activity in metabolic diseases.
Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism.
Multiple Myeloma
Glucose metabolism as a target of histone deacetylase inhibitors.
Hexokinase-2 Expression in MET-positive FDG-negative Multiple Myeloma.
Hypoxia-inducible hexokinase-2 enhances anti-apoptotic function via activating autophagy in multiple myeloma.
Low expression of hexokinase-2 is associated with false-negative FDG-positron emission tomography in multiple myeloma.
Low hexokinase-2 expression-associated false-negative 18F-FDG PET/CT as a potential prognostic predictor in patients with multiple myeloma.
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
Multiple System Atrophy
TIGAR inclusion pathology is specific for Lewy body diseases.
Muscular Dystrophies
Isoenzymes of hexokinase in human muscular dystrophy.
The increase in hexokinase activity in hereditary avian muscular dystrophy.
Myocardial Infarction
Enhanced activity and subcellular redistribution of myocardial hexokinase after acute myocardial infarction.
Inhibition of carnitine synthesis modulates protein contents of the cardiac sarcoplasmic reticulum Ca2+-ATPase and hexokinase type I in rat hearts with myocardial infarction.
Myocardial Ischemia
sDR5-Fc inhibits macrophage M1 polarization by blocking the glycolysis.
[Diagnostic value of determining hexokinase activity of leukocytes in ischemic heart disease]
Myocarditis
[Glycolysis and hexokinase activity in the subcellular fraction of the rabbit myocardium in adrenalinic myocarditis]
Myotonia
Changes of hexokinase in the enzyme activity pattern of muscle in human myotonia congenita and in experimental myotonia of the rat.
[The skeletal muscle hexokinase activity of white rats with experimental myotonia]
Myotonia Congenita
Changes of hexokinase in the enzyme activity pattern of muscle in human myotonia congenita and in experimental myotonia of the rat.
Myotonic Dystrophy
Correlation between decreased myocardial glucose phosphorylation and the DNA mutation size in myotonic dystrophy.
Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface.
Nasopharyngeal Carcinoma
hsa-miR-9-5p Down-Regulates HK2 and Confers Radiosensitivity to Nasopharyngeal Carcinoma.
Long-term prognostic implications and therapeutic target role of hexokinase II in patients with nasopharyngeal carcinoma.
Neoplasm Metastasis
AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-?B, HIF1?, MMP2, and MMP9 upregulation.
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.
c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.
Glycolytic enzyme activities in breast cancer metastases.
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.
Hexokinase 2 is a determinant of neuroblastoma metastasis.
Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer.
Hexokinase II-Derived Cell-Penetrating Peptide Mediates Delivery of MicroRNA Mimic for Cancer-Selective Cytotoxicity.
Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria.
Identification of novel alternative splicing isoform biomarkers and their association with overall survival in colorectal cancer.
PGC1? Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression.
Reciprocal immunohistochemical expression of sodium/iodide symporter and hexokinase I in primary thyroid tumors with synchronous cervical metastasis.
S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2.
Taurine upregulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma.
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
[Diagnostic and prognostic significance of biochemical indicators in colorectal neoplasms]
[The role of hexokinase 2 in the metastasis of hepatocellular carcinoma cells].
Neoplasms
(18)F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: A clinicopathological study.
(18)FDG PET for grading malignancy in thymic epithelial tumors: Significant differences in (18)FDG uptake and expression of glucose transporter-1 and hexokinase II between low and high-risk tumors: Preliminary study.
18F-FDG-PET of musculoskeletal tumors: a correlation with the expression of glucose transporter 1 and hexokinase II.
18F-fluorodeoxyglucose uptake in tumor.
2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner.
2-[18F]-2-deoxy-D-glucose (FDG) uptake in human tumor cells is related to the expression of GLUT-1 and hexokinase II.
3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective "small molecule" anti-cancer agent taken from labside to bedside: introduction to a special issue.
3-Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau.
3-Bromopyruvate attenuates experimental pulmonary hypertension via inhibition of glycolysis.
3-bromopyruvate enhanced daunorubicin-induced cytotoxicity involved in monocarboxylate transporter 1 in breast cancer cells.
3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-1 through the PI3K/Akt signaling pathway.
3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells : in vitro and in vivo findings.
6-phosphogluconate dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate isomerase, and hexokinase activity ratios in some human tumor cytosols.
A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses.
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis.
A pan-cancer analysis of molecular characteristics and oncogenic role of hexokinase family genes in human tumors.
A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers.
A recent application of fluoro-18-deoxyglucose positron emission tomography, treatment monitoring with a mammalian target of rapamycin inhibitor: an example of a patient with a desmoplastic small round cell tumor.
A tumor agnostic therapeutic strategy for Hexokinase 1 Null/Hexokinase 2 positive cancers.
A variant of hexokinase isoenzymes detected in ascites tumor cells.
Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in lipoblastic and neurogenic proliferations.
Activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase in smooth muscle proliferation.
Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.
Adenine Nucleotide Translocase 2 as an Enzyme Related to [18F] FDG Accumulation in Various Cancers.
Adenylate kinase is a source of ATP for tumor mitochondrial hexokinase.
Aegle marmelos differentially affects hepatic markers of glycolysis, insulin signalling pathway, hypoxia, and inflammation in HepG2 cells grown in fructose versus glucose-rich environment.
Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.
Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells.
Alloxan and ninhydrin inhibition of hexokinase from pancreatic islets and tumoural insulin-secreting cells.
Alterations in glucose metabolism proteins responsible for the Warburg effect in esophageal squamous cell carcinoma.
Altered glycolysis results in drug-resistant in clinical tumor therapy.
Altered oxidative stress and carbohydrate metabolism in canine mammary tumors.
An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+ Multiple Myeloma.
An HPLC method for the determination of adenosine diphosphate: An important marker of hexokinase activity in metabolic diseases.
Analysis of the Effects of Hexokinase 2 Detachment From Mitochondria-Associated Membranes with the Highly Selective Peptide HK2pep.
Analysis of the roles of glucose transporter 1 and hexokinase 2 in the metabolism of glucose by extrahepatic bile duct cancer cells.
Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer.
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
Anomeric specificity of hexokinase in rat, human, and murine tumor cells.
ANT2 Isoform Required for Cancer Cell Glycolysis.
Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model.
Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.
Ascites tumor mitochondrial hexokinase II. Effect of binding on kinetic properties.
ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics.
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.
Biochemical alterations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors from rats subjected to caloric restriction.
Bioflavonoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria.
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography.
Biologic correlates of intratumoral heterogeneity in 18F-FDG distribution with regional expression of glucose transporters and hexokinase-II in experimental tumor.
Biological characterisation of breast cancer by means of PET.
Bis(3,5-diiodo-2,4,6-trihydroxyphenyl)squaraine: A novel candidate in photodynamic therapy for skin cancer models in vivo.
By blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma.
By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice.
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
Cancer cell metabolism: implications for therapeutic targets.
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1? Axis of Breast Cancer Cells.
Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation.
Cellular and molecular characterization of a feline insulinoma.
Cerulenin-induced apoptosis is mediated by disrupting the interaction between AIF and hexokinase II.
Characteristics of glucokinase of the Kirkman insulinoma.
Characterization of hexokinase isoenzyme types I and II in ascites tumor cells by an interaction with mitochondrial membrane.
Characterization of porin isoforms expressed in tumor cells.
Characterization of some glycolytic enzymes from human retina and retinoblastoma.
Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival.
Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2.
Cleavage of hexokinase II to two domains by trypsin without significant change in catalytic activity.
Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹?F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors.
Clinicopathological presentation of varying 18F-FDG uptake and expression of glucose transporter 1 and hexokinase II in cases of hepatocellular carcinoma and cholangiocellular carcinoma.
Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells.
Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer.
Combination of arsenic trioxide and cisplatin synergistically inhibits both hexokinase activity and viability of Ehrlich ascites carcinoma cells.
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor (HIF)-1{alpha}.
Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1? in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.
Comparative effects of single-mode vs. duration-matched concurrent exercise training on body composition, low-grade inflammation, and glucose regulation in sedentary, overweight, middle-aged men.
Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: comparison with a hexokinase from novikoff ascites tumor.
Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis.
Correction: PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
Correlation between biological marker expression and F-fluorodeoxyglucose uptake in cervical cancer measured by positron emission tomography.
CORRELATION BETWEEN SERUM HEXOKINASE ACTIVITY AND MALIGNANT TUMORS IN MAN.
Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas.
D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate.
D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects.
Defective regulation of glucokinase in rat pancreatic islet cell tumours.
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.
Deregulation of energetic metabolism in the clear cell renal cell carcinoma: A multiple pathway analysis based on microarray profiling.
Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia.
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase.
Development of artificial chimerical gene regulatory elements specific for cancer gene therapy.
Diclofenac impairs the proliferation and glucose metabolism of triple-negative breast cancer cells by targeting the c-Myc pathway.
Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages.
Different glucose uptake and glycolytic mechanisms between hepatocellular carcinoma and intrahepatic mass-forming cholangiocarcinoma with increased (18)F-FDG uptake.
Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.
Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus Hürthle Cell Neoplasms: A Retrospective Analysis.
Differential regulation of glucokinase activity in pancreatic islets and liver of the rat.
Dioscin Inhibited Glycolysis and Induced Cell Apoptosis in Colorectal Cancer via Promoting c-myc Ubiquitination and Subsequent Hexokinase-2 Suppression.
Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.
Disruption of the hexokinase-VDAC complex for tumor therapy.
Dual-time-point FDG-PET/CT Imaging of Temporal Bone Chondroblastoma: A Report of Two Cases.
Early evaluation of the effects of chemotherapy with longitudinal FDG small-animal PET in human testicular cancer xenografts: early flare response does not reflect refractory disease.
Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer.
Effect of lonidamine on human malignant gliomas: biochemical studies.
Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
Effect of N6-(delta2-isopentenyl)adenosine treatment in vivo on hexokinase activity of mouse L 1210 cells.
Effect of nutrient intake on intramuscular glucose metabolism during the early growth stage in cross-bred steers (Japanese Black male?×?Holstein female).
Effect of tumors with different growth rates on enzymes in host liver.
Effects of various dietary fatty acids on enzyme activities of carbohydrate and glutamine metabolism and the metabolic response of lymphocytes and macrophages during Walker-256 ascites cell tumour growth in rats.
Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells".
Efficacy of Terminalia arjuna (Roxb.) on N-nitrosodiethylamine induced hepatocellular carcinoma in rats.
Efflux of adenine nucleotides in mitochondria from rat tumor cells of varying growth rates.
Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding.
Enhanced antitumor effects of follicle-stimulating hormone receptor-mediated hexokinase-2 depletion on ovarian cancer mediated by a shift in glucose metabolism.
Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition.
Enzyme activities and isozyme patterns in human lung tumors.
Enzyme activities in normal, dysplastic, and cancerous human breast tissues.
Enzyme pathology and the histologic categorization of human lung tumors: the continuum of quantitative biochemical indices of neoplasticity.
Enzymes of glucose metabolism in carcinoma of the cervix and endometrium of the human uterus.
Enzymes of glucose metabolism in cultured human gliomas: neoplasia is accompanied by altered hexokinase, phosphofructokinase, and glucose-6-phosphate dehydrogenase levels.
Erratum to: Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.
Establishment of a [18F]-FDG-PET/MRI Imaging Protocol for Gastric Cancer PDX as a Preclinical Research Tool.
Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG-PET imaging combined with proteomic approaches.
Evaluation of experimental liver tumors using fluorine-18-2-fluoro-2-deoxy-D-glucose PET.
Evaluation of Glucose Uptake in Normal and Cancer Cell Lines by Positron Emission Tomography.
Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment.
Evaluation of the antiproliferative activity of 106 marine microbial metabolites against human lung cancer cells and potential antiproliferative mechanism of purpuride G.
Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines.
Evidence that does not support PKM2-catalyzed reaction as a rate-limiting step in cancer cell glycolysis.
Evidence that transcription of the hexokinase gene is increased in a rapidly growing rat hepatoma.
Exosomal Circ-MEMO1 Promotes the Progression and Aerobic Glycolysis of Non-small Cell Lung Cancer Through Targeting MiR-101-3p/KRAS Axis.
Expression and activity of hexokinase in the early mouse embryo.
Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors.
Expression of glucose transporter isoforms (GLUT1, GLUT2) and activities of hexokinase, pyruvate kinase, and malic enzyme in preneoplastic and neoplastic rat renal basophilic cell lesions.
Expression of glucose transporter-1, hexokinase-II, proliferating cell nuclear antigen and survival of patients with pancreatic cancer.
Expression of hexokinase 2 in epithelial ovarian tumors and its clinical significance in serous ovarian cancer.
Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.
Expression of two type II-like tumor hexokinase RNA transcripts in cancer cell lines.
FDG accumulation and tumor biology.
FDG PET imaging of Ela1-myc mice reveals major biological differences between pancreatic acinar and ductal tumours.
FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model.
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.
Flavonoids Targeting HIF-1: Implications on Cancer Metabolism.
Fructose 1,6-Bisphosphatase 1 Expression Reduces 18F-FDG Uptake in Clear Cell Renal Cell Carcinoma.
Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2.
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.
Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour.
Gene expression patterns and tumor uptake of 18F-FDG, 18F-FLT, and 18F-FEC in PET/MRI of an orthotopic mouse xenotransplantation model of pancreatic cancer.
Glucose 6-phosphate-dependent binding of hexokinase to membranes of ascites tumor cells.
Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited.
Glucose catabolism in brain. Intracellular localization of hexokinase.
Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase.
Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53.
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.
Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP.
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase.
Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression.
Glucose metabolism in cancer: importance of transcription factor-DNA interactions within a short segment of the proximal region og the type II hexokinase promoter.
Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase.
Glucose transporter protein-independent tumor cell accumulation of fluorine-18-AFDG, a lipophilic fluorine-18-FDG analog.
Glucose utilization by tumor cells: a post-translational modification of mitochondrial hexokinase may play a regulatory role.
Glucose utilization by tumor cells: the enzyme hexokinase autophosphorylates both its N- and C-terminal halves.
Glucose-6-phosphatase Expression-Mediated [18F]FDG Efflux in Murine Inflammation and Cancer Models.
Glycolysis and growth rate in normal and in hexokinase-transfected NIH-3T3 cells.
Glycolysis back in the limelight: systemic targeting of HK2 blocks tumor growth.
Glycolytic enzyme activities in breast cancer metastases.
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Growth condition-dependent synchronized changes in transcript levels of type II hexokinase and type 1 glucose transporter in tumor cells.
Growth control of C6 glioma in vivo by nerve growth factor.
Hacking hexokinase halts tumor growth.
HectH9 hijacks glucose metabolism to fuel tumor growth.
Hepatic glucose-6-phosphatase-? deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.
Heterogeneity of glycolytic enzyme activity and isozyme composition of pyruvate kinase in breast cancer.
Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway.
Hexokinase 2 dimerization and interaction with voltage-dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer.
Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients.
Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+ -dependent death of cancer cells.
Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.
Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters.
Hexokinase 2 is a determinant of neuroblastoma metastasis.
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.
Hexokinase 2 is dispensable for T cell-dependent immunity.
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.
Hexokinase 2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin.
Hexokinase 2 Promotes Cell Growth and Tumor Formation Through the Raf/MEK/ERK Signaling Pathway in Cervical Cancer.
Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer.
Hexokinase 2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts.
Hexokinase 2 required in tumors.
Hexokinase activity in tumorigenic and nontumorigenic cell cultures derived from mouse ascites tumor cells.
Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma.
Hexokinase binding to mitochondria: a basis for proliferative energy metabolism.
Hexokinase expression in liver preneoplasia and neoplasia.
Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.
Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism.
Hexokinase II in CD133+ and CD133- Hepatoma BEL-7402 Cells.
Hexokinase II inhibition by 3-bromopyruvate sensitizes myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin.
Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.
Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase.
Hexokinase II-Derived Cell-Penetrating Peptide Mediates Delivery of MicroRNA Mimic for Cancer-Selective Cytotoxicity.
Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells.
Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria.
Hexokinase II: the integration of energy metabolism and control of apoptosis.
Hexokinase inhibition after the addition of glucose to Ehrlich-Lettré ascites tumor cells under aerobiosis.
Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells.
Hexokinase isoenzymes from anaplastic and differentiated medullary thyroid carcinoma in the rat.
Hexokinase isoenzymes in the diagnosis of gastric and esophageal neoplasms.
Hexokinase isozyme patterns of human uterine tumors.
Hexokinase isozymes in human neoplastic and fetal tissues: the existence of hexokinase II in malignant tumors and in placenta.
Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC.
Hexokinase receptors: preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites.
Hexokinase specificity of some tumor tissue extracts.
Hexokinase type II: a novel tumor-specific promoter for gene-targeted therapy differentially expressed and regulated in human cancer cells.
Hexokinase, differentiation and growth rates of transplanted rat tumors.
Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy.
Hexokinase-2 Expression in MET-positive FDG-negative Multiple Myeloma.
Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.
Hexokinase-mitochondrial interactions regulate glucose metabolism differentially in adult and neonatal cardiac myocytes.
Hexokinase: the direct link between mitochondrial and glycolytic reactions in rapidly growing cancer cells.
HIF-1alpha Modulates Energy Metabolism in Cancer Cells by Inducing Over-expression of Specific Glycolytic Isoforms.
HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms.
High expression of hexokinase domain containing 1 is associated with poor prognosis and aggressive phenotype in hepatocarcinoma.
High Km glucose-phosphorylating (glucokinase) activities in a range of tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor mannoheptulose.
Histochemical evaluation of energy metabolism in rat glioma.
HKDC1 C-terminal based peptides inhibit extranodal natural killer/T-cell lymphoma by modulation of mitochondrial function and EBV suppression.
HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway.
HNF4A-AS1/hnRNPU/CTCF axis as a therapeutic target for aerobic glycolysis and neuroblastoma progression.
Homeostatic derangement in the CBA rodent host during the growth of the CaNT tumor.
HOTAIR/miR-125 axis-mediated Hexokinase 2 expression promotes chemoresistance in human glioblastoma.
Human steroid sulfatase enhances aerobic glycolysis through induction of HIF1? and glycolytic enzymes.
Identification of a Mitochondrial-Binding Site on the Amino-Terminal End of Hexokinase II.
Identification of a mitochondrial-binding site on the N-terminal end of hexokinase II.
Identification of plant-based hexokinase 2 inhibitors: combined molecular docking and dynamics simulation studies.
Identification of regulatory properties of metabolic networks by graph theoretical modeling.
Identifying strategies to target the metabolic flexibility of tumours.
Identity, release, and binding of mitochondrial-bound hexokinases in mammary glands and adenocarcinomas of lactating mice.
Immune effects of glycolysis or oxidative phosphorylation metabolic pathway in protecting against bacterial infection.
Immunochemical analysis of the membrane proteins of rat liver and Zajdela hepatoma mitochondria.
Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response.
Importance of determinations of serum hexokinase, aldolase, and lactate dehydrogenase activities, and of the lactate/pyruvate-quotient in the diagnosis of malignant tumors.
In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death.
In silico construction of HK2-VDAC1 complex and investigating the HK2 binding-induced molecular gating mechanism of VDAC1.
In vivo assessment of glucose metabolism in hepatocellular carcinoma with FDG-PET.
Inferring therapeutic targets from heterogeneous data: HKDC1 is a novel potential therapeutic target for cancer.
Influence of insulin on estrogen-induced responses in the r3230ac mammary carcinoma.
Influence of resistance to 5-fluorouracil and tomudex on [18F]?FDG incorporation, glucose transport and hexokinase activity.
Influence of thiopental on intracellular distribution of hexokinase activity in various tumor cells.
Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer.
Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate.
Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth.
Inhibition of hexokinase and protein kinase activities of tumor cells by a chloromethyl ketone derivative of lactic acid.
Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis.
Inhibition of Non-flux-Controlling Enzymes Deters Cancer Glycolysis by Accumulation of Regulatory Metabolites of Controlling Steps.
Inhibitory action of the antitumor agent lonidamine on mitochondrial respiration of Trypanosoma cruzi and T. brucei.
Inhibitory effects of 3-bromopyruvate in human nasopharyngeal carcinoma cells.
Inihibition of Glycolysis by Using a Micro/Nano-Lipid Bromopyruvic Chitosan Carrier as a Promising Tool to Improve Treatment of Hepatocellular Carcinoma.
INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells.
Insulin and hypoxia-inducible factor-1 cooperate in pancreatic cancer cells to increase cell viability.
Insulin, growth factors, and cancer cell energy metabolism: an hypothesis on oncogene action.
Insulin-like growth factor I induces tumor hexokinase RNA expression in cancer cells.
Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells.
Intracellular distribution of hexokinase in the tissue zones of rat kidney.
Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location.
Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line.
Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution.
Isoenzyme pattern and subcellular localization of hexokinases in human breast cancer and nonpathological breast tissue.
Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase, phosphoglucomutase and lactate dehydrogenase in uterine cancer.
Isozyme patterns of normal, benign, and malignant human breast tissues.
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1? signaling pathway.
Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway.
Kinetic analysis of glucose metabolism by FDG-PET versus proliferation index of Ki-67 in meningiomas--comparison with gliomas.
Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase A: consequences for cancer energy metabolism.
Kinetic characterization of hexokinase isoenzymes from glioma cells: implications for FDG imaging of human brain tumors.
Kinetics of transport and phosphorylation of glucose in cancer cells.
L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma.
Latent Membrane Protein 1 Promotes Tumorigenesis Through Upregulation of PGC1? Signaling Pathway.
Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2.
Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.
Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian Malignancy.
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target.
Lipids, Mitochondria and Cell Death: Implications in Neuro-oncology.
Lithium detaches hexokinase from mitochondria and inhibits proliferation of B16 melanoma cells.
LncRNA loc285194 inhibits tumor growth of laryngeal squamous cell carcinoma cells by downregulating hexokinase 2.
Local toxicity of hepatic arterial infusion of hexokinase II inhibitor, 3-bromopyruvate: In vivo investigation in normal rabbit model.
Long Non-Coding RNA C1QTNF1 Antisense RNA 1 Upregulates Hexokinase 2 by Sponging microRNA-484 to Promote the Malignancy of Colorectal Cancer.
Long non-coding RNA HOTAIR promotes cancer cell energy metabolism in pancreatic adenocarcinoma by upregulating hexokinase-2.
Long noncoding RNA MALAT1 mediates stem cell-like properties in human colorectal cancer cells by regulating miR-20b-5p/Oct4 axis.
Long Term Prognostic Implications of Expression of Glucose Transporter-1 and Hexokinase II in Patients with Stage I Uterine Leiomyosarcoma.
Lonidamine in the combined treatment of malignant gliomas. A randomized study.
Lonidamine, a new approach to cancer therapy.
Low expression of hexokinase-2 is associated with false-negative FDG-positron emission tomography in multiple myeloma.
Luteolin-7-O-?-d-Glucoside Inhibits Cellular Energy Production Interacting with HEK2 in Keratinocytes.
Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.
Mechanisms related to [18F]fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice.
Metabolic characteristics distinguishing intrahepatic cholangiocarcinoma: a negative pilot study of (18)F-fluorocholine PET/CT clarified by transcriptomic analysis.
Metabolic characterization of three hamster melanoma variants.
Metabolic control analysis indicates a change of strategy in the treatment of cancer.
Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma.
Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers.
Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: a therapeutic implication.
Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1? mediated signal pathway.
Metabolic vulnerabilities in endometrial cancer.
METABOLISM OF ASCITES TUMOR CELLS. II. INHIBITION OF RESPIRATION BY GLYCOLYZABLE AND NONGLYCOLYZABLE SUGARS PHOSPHORYLATED BY HEXOKINASE.
Methyl jasmonate binds to and detaches mitochondria-bound hexokinase.
Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis.
MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene.
MicroRNA-143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer.
MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.
Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding.
MiR-125b-5p suppressed the glycolysis of laryngeal squamous cell carcinoma by down-regulating hexokinase-2.
miR-139-5p inhibits aerobic glycolysis, cell proliferation, migration, and invasion in hepatocellular carcinoma via a reciprocal regulatory interaction with ETS1.
miR-143 regulates hexokinase 2 expression in cancer cells.
MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer.
MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.
miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells.
miR?185 regulates the growth of osteosarcoma cells via targeting Hexokinase 2.
Mitochondria and cancer: Warburg addressed.
Mitochondria, hexokinase and pyruvate kinase isozymes in the aerobic glycolysis of tumor cells.
Mitochondria-acting hexokinase II peptides carried by short-length carbon nanotubes with increased cellular uptake, endosomal evasion, and enhanced bioactivity against cancer cells.
Mitochondria-bound hexokinase as target for therapy of malignant gliomas.
Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention.
Mitochondrial hexokinase of rat hepatoma cells in culture: solubilization and kinetic properties.
Mitochondrial membrane-bound hexokinase of ascites tumor cells. Functional implications of lysine residues studied by modification with imidoesters.
Mitochondrial mutations in cancer.
Mitochondrial VDAC and hexokinase together modulate plant programmed cell death.
Mitochondrial VDAC1: Function in Cell Life and Death and a Target for Cancer Therapy.
Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents.
Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake.
Molecular model of hexokinase binding to the outer mitochondrial membrane porin (VDAC1): Implication for the design of new cancer therapies.
Monitoring Response to Radiotherapy in Human Squamous Cell Cancer Bearing Nude Mice: Comparison of 2'-deoxy-2'-[(18)F]fluoro-D: -glucose (FDG) and 3'-[ (18)F]fluoro-3'-deoxythymidine (FLT).
Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment.
Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-??.
Neuroendocrine differentiation of LNCaP cells suggests: VDAC in the cell membrane is involved in the extrinsic apoptotic pathway.
New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases/mTOR Signaling Pathway.
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
New natural inhibitors of hexokinase 2 (HK2): Steroids from Ganoderma sinense.
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion.
Novel predictive biomarkers for cervical cancer prognosis.
Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis.
Nucleocytoplasmic shuttling of hexokinase II in a cancer cell.
Oncogenes in tumor metabolism, tumorigenesis, and apoptosis.
Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.
Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT.
Overexpression of metabolic markers HK1 and PKM2 contributes to lymphatic metastasis and adverse prognosis in Chinese gastric cancer.
Overexpression of METTL3 associated with the metabolic status on 18F-FDG PET/CT in patients with Esophageal Carcinoma.
p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer.
PD-L1 in Lung Adenocarcinoma: Insights into the Role of 18F-FDG PET/CT.
PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2.
PGC1? Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
PGC1? Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression.
pH in human tumor xenografts and transplanted rat tumors: effect of insulin, inorganic phosphate, and m-iodobenzylguanidine.
Physicochemical properties and isoenzyme composition of hexokinase from normal and malignant human tissues.
Phytometabolites Targeting Warburg Effect in Cancer Cells: A Mechanistic Review.
PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma.
PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer.
PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma.
Polyamines stimulate the binding of hexokinase type II to mitochondria.
Poor prognosis of hexokinase 2 overexpression in solid tumors of digestive system: a meta-analysis.
Porin interaction with hexokinase and glycerol kinase: metabolic microcompartmentation at the outer mitochondrial membrane.
Positron emission tomography in the management of lymphomas.
Potassium ions promote hexokinase-II dependent glycolysis.
Potentiation of radiation effects on two murine tumors by lonidamine.
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Prognostic predictive value of 18F-fluorodeoxyglucose positron emission tomography for patients with pancreatic cancer.
Prognostic role of glycolysis for cancer outcome: evidence from 86 studies.
Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer.
Prognostic Significance of 18F-FDG PET/CT Metabolic Parameters and Tumor Galectin-1 Expression in Patients With Surgically Resected Lung Adenocarcinoma.
Prognostic Significance of the Metabolic Marker Hexokinase-2 in Various Solid Tumors: A Meta-Analysis.
Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line.
Quantitative determinations of the steady state transcript levels of hexokinase isozymes and glucose transporter isoforms in normal rat tissues and the malignant tumor cell line AH130.
Quantitative Proteomics Analysis Revealed the Potential Role of lncRNA Ftx in Promoting Gastric Cancer Progression.
Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine.
Recent chemotherapy reduces the sensitivity of [18F]fluorodeoxyglucose positron emission tomography in the detection of colorectal metastases.
Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids.
Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma.
Reciprocal immunohistochemical expression of sodium/iodide symporter and hexokinase I in primary thyroid tumors with synchronous cervical metastasis.
Red blood cell hexokinase in tumor bearing mice.
Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.
Regulation of cellular energy metabolism: the Crabtree effect.
Regulation of hexokinase binding to VDAC.
Regulation of HK2 expression through alterations in CpG methylation of the HK2 promoter during progression of hepatocellular carcinoma.
Regulation of mitochondrial hexokinase in cultured HT 29 human cancer cells. An ultrastructural and biochemical study.
Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome.
Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer.
Relationship between (18)F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma.
Relationship between erythrocyte hexokinase in cancer patients and red cell age.
Relationship between retention index in dual-phase (18)F-FDG PET, and hexokinase-II and glucose transporter-1 expression in pancreatic cancer.
Relative value of oestrogen receptor assay, lactoferrin content, and glucose-6-phosphate dehydrogenase activity as prognostic indicators in primary breast cancer.
Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130.
Role of aerobic glycolysis in genetically engineered mouse models of cancer.
Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate.
Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA.
Role of sp transcription factors in the regulation of cancer cell metabolism.
S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2.
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy.
Significance of serum phosphohexose isomerase, hexokinase and aldolase in carcinoma ovary.
Single Nucleotide Polymorphisms in MIR143 Contribute to Protection Against Non-Hodgkin Lymphoma (NHL) in Caucasian Populations.
Sirtuin 6 and metabolic genes interplay in Warburg effect in cancers.
Solid tumors and enzyme activity in human lymphocytes.
Soluble and particle-bound hexokinase in normal and tumour tissues of rats.
Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.
Stability of hexokinase II in vitro and in ascites tumor cells.
Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo.
Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines.
Structure based discovery of novel hexokinase 2 inhibitors.
Structure/function relationships in hexokinase. Site-directed mutational analyses and characterization of overexpressed fragments implicate different functions for the N- and C-terminal halves of the enzyme.
Studies on the mode of action of RC4, a new anti-cancer agent containing ethyleneimino ring. I. Effects of RC4 and allied agents on glycolysis, respiration, hexokinase and phosphatase of Ehrlich ascites tumor cells and on choline-esterase of human blood.
Study on ATP-generating system and related hexokinase activity in mitochondria isolated from undifferentiated or differentiated HT29 adenocarcinoma cells.
Succinate aggravates NAFLD progression to liver cancer on the onset of obesity: An in silico model.
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells.
Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis.
Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy.
Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines.
Synthesis of radioiodinated 1-deoxy-nojirimycin derivatives: novel glucose analogs.
Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic.
Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis.
Targeting cellular metabolism to improve cancer therapeutics.
Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer.
Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth.
Targeting hexokinase II as a possible therapy for cholangiocarcinoma.
Targeting Hexokinase II to mitochondria to modulate energy metabolism and reduce ischemia-reperfusion injury in heart.
Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43266-283.
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.
The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer.
The combination of the expression of hexokinase 2 and pyruvate kinase M2 is a prognostic marker in patients with pancreatic cancer.
The complex role of the triphenylmethyl motif in anticancer compounds.
The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins.
The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition.
The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression.
The effect of glucosone on the proliferation and energy metabolism of in vitro grown Ehrlich ascites tumor cells.
The effect of lymphoma and other neoplasms on hepatic and plasma enzymes of the host rat.
The energy blocker inside the power house: Mitochondria targeted delivery of 3-bromopyruvate.
The hexokinase activity of animal tumours.
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate.
The impairment of respiration by glycolysis in the Lewis lung carcinoma.
The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro.
The insulin-like growth factor-system in a patient with diffuse large B-cell non-Hodgkin's lymphoma and lactic acidosis.
The interaction among glucose transport, hexokinase, and glucose-6-phosphatase with respect to 3H-2-deoxyglucose retention in murine tumor models.
The membrane-bound hexokinase as a potential marker for malignancy in human gliomas.
The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma.
The mitochondrial voltage-dependent anion channel 1 in tumor cells.
The Natural Product ?-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.
The progress and development of GLUT1 inhibitors targeting cancer energy metabolism.
The role of hexokinase in cardioprotection - mechanism and potential for translation.
The role of mitochondrial hexokinase binding in the abnormal energy metabolism of tumor cell lines.
The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy.
The role of the mitochondrial outer membrane in energy metabolism of tumor cells.
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
The tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma.
The voltage dependent anion channel affects mitochondrial cholesterol distribution and function.
Therapeutic effect of tamoxifen and energy-modulating vitamins on carbohydrate-metabolizing enzymes in breast cancer.
Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer.
Transcriptional targeting of virus-mediated gene transfer by the human hexokinase II promoter.
Transient isolation of the hexokinase reaction from the glycolytic sequence on initiation of glycolysis in ascites tumor cells.
Tristetraprolin-mediated hexokinase 2 expression regulation contributes glycolysis in cancer cells.
Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect.
Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts.
Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma.
Up-regulation of hexokinase II contributes to rituximab-chemotherapy resistance and is a clinically relevant target for therapeutic development.
Up-regulation of hexokinaseII in myeloma cells: targeting myeloma cells with 3-bromopyruvate.
Up-regulation of Key Glycolysis Proteins in Cancer Development.
Upregulation of hypoxia-inducible factor-1alpha mRNA and its clinical significance in non-small cell lung cancer.
Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer.
Variability in glucose transporter-1 levels and hexokinase activity in human melanoma.
VDAC, a multi-functional mitochondrial protein as a pharmacological target.
VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress.
VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia.
VDAC1: from structure to cancer therapy.
Viral
Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer.
Voltage-dependent anion channel (VDAC) as mitochondrial governator--thinking outside the box.
Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics.
Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.
Walker 256 tumour growth causes marked changes of glutamine metabolism in rat small intestine.
Warburg effect increases steady-state ROS condition in cancer cells through decreasing their antioxidant capacities (Anticancer effects of 3-bromopyruvate through antagonizing Warburg effect).
Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen.
Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism.
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis.
ZHX2 and ZHX3 repress cancer markers in normal hepatocytes.
[18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung.
[18F]fluorodeoxyglucose uptake in recurrent thyroid cancer is related to hexokinase i expression in the primary tumor.
[Activity of soluble and bound hexokinase in transplantable hepatomas of different degrees of malignancy, and in normal and regenerating mouse livers]
[Activity of the key glycolysis and respiration enzymes in the rat liver in chemical carcinogenesis]
[Analysis of glucose metabolism in patients with esophageal cancer by PET: estimation of hexokinase activity in the tumor and usefulness for clinical assessment using 18F-fluorodeoxyglucose]
[Analysis of hexokinase isoenzymes in the differential diagnosis of malignant and benign tumors]
[Biochemical features of the liver of high and low cancer mouse strains and primary spontaneous hepatomas]
[Brain metabolism of sarcoma 45-bearing rats undergoing radiation and the effect of hyperthermia on the tumor]
[Can fluorodeoxyglucose-positron emission tomography evaluate the functional differentiation of hepatocellular carcinoma]
[Carbohydrate metabolism enzymatic activity and its alteration under the influence of thyroid hormone during tumor growth]
[Carbohydrate metabolism in the kidneys of rats with dimethylnitrosamine-induced tumors]
[Catalytic properties and isoenzyme composition of hexokinase in thyroid gland normal and neoplastic tissue]
[Cooperation of membrane proteins and cytosolic proteins in metabolic regulation--involvement of binding of hexokinase to mitochondria in regulation of glucose metabolism and association and complex formation between membrane proteins and cytosolic proteins in regulation of active oxygen production]
[CORRELATIONS BETWEEN THE BLOOD SERUM HEXOKINASE ACTIVITY AND MALIGNANT TUMORS IN MAN.]
[Determination of hexokinase activity in body fluids in malignant neoplasms]
[DETERMINATION OF MICHAELIS CONSTANTS OF HEXOKINASE IN NORMAL AND TUMOR TISSUE.]
[Diagnostic and prognostic significance of biochemical indicators in colorectal neoplasms]
[Distribution of hexokinase in Ehrlich ascites tumor cells]
[Distribution of hexokinase in Ehrlich's ascites tumor cells.]
[Distribution of polyribosomes synthesizing hexokinase in a cancer cell]
[Effects of stromal cells derived from the normal prostate on the glycolysis of prostate cancer cells].
[Effects of Tramadol on Insulin Resistance during Cesarean Section Complicated with Gestational Diabetes Mellitus].
[Estradiol reception and enzyme induction in mouse mammary gland neoplasms]
[Estrogen dependence of mammary gland tumors: the mechanisms of the disorder and the evaluation criteria]
[FURTHER STUDIES ON THE PROBLEM OF HEXOKINASE LOCALIZATION IN TUMOR CELLS.]
[Hemocirculation and metabolism in intraventricular tumors: kinetic analysis of glucose metabolism]
[Hexokinase activity in blood serum during carcinogenesis]
[Hexokinase activity in erythrocytes, liver and brain of normal rats, roentgen irradiated rats and rats with Guerin tumor and chronic hypoxia induced with potassium cyanide (KCN)]
[Hexokinase activity of erythrocytes in cancer patients]
[Hexokinase and glucokinase activity in human and animal tumors]
[Hexokinase isoenzyme in human malignant tumor tissues]
[Hexokinase test for determining precancerous diseases and cancer of the rectum and large intestine]
[Hexokinase test in patients with malignant tumors]
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
[Identification and characterization of hexokinase isozyme predominantly expressed in malignant tumor cells]
[Identification of hexokinase synthesizing polyribosomes in human normal and tumor tissues]
[Inhibition of Sirolimus on the growth of pancreatic carcinoma and its effect on the expression of glucose transporter and hexokinase ?].
[Isoforms of human and animal tumor hexokinase]
[Kinetics of glucose metabolism in central neurocytomas]
[Longitudinal analysis of glucose metabolism in recurrent meningioma]
[On the use and clinical importance of the hexokinase test in diagnosis of cancer of the cervix uteri]
[PET evaluation of glucose metabolism in cancer]
[Physico-chemical and kinetic properties of hexokinase isoenzymes from human normal and tumor tissues]
[Sensitivity of hexokinase and glucokinase to hormonal action during hepatocarcinogenesis]
[Serum hexokinase activity in chickens with viral tumors]
[Several peculiarities of hexokinase of malignant and benign tumors in man]
[STUDIES ON THE PHYSIOLOGICAL FUNCTIONS OF THE MITOCHONDRIAL BOUND HEXOKINASE OF ASCITES TUMOR CELLS.]
[Studies on the soluble and particular hexokinase in Ehrlich ascites tumor cells]
[Subcellular distribution of hexokinase in hepatoma and its electrophoretic properties]
[Subcellular localization, isoenzyme spectrum and properties of hexokinase from sarcoma M-1]
[Targeting the gene of glucose metabolism for the treatment of advanced gliomas]
[The precipitin test for cancer, serum hexokinase and polarography for recognition of malignant tumors]
[Theoretical premises and methodology for studying hexokinase for the purpose of diagnosing malignant neoplasms]
[Tumorous origin of the hexokinase in human biological fluids]
[Voltage-dependent anion channel and hematological malignancies]
Neoplastic Cells, Circulating
Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients.
Nervous System Diseases
Role of hexokinase and VDAC in neurological disorders.
Neuritis
[Activity and isoenzymatic makeup of the hexokinase of rapid and slow muscles in the rabbit normally and the experimental allergic polyneuritis]
[Hexokinase and dehydrogenases of the pentose pathway in the skeletal muscles of rabbits with experimental allergic polyneuritis]
[Neural regulation of the activity of energy metabolism enzymes in differently functioning rabbit skeletal muscles]
Neuritis, Autoimmune, Experimental
[Neural regulation of the activity of energy metabolism enzymes in differently functioning rabbit skeletal muscles]
Neuroblastoma
Barbiturates suppress glucose utilization by inhibition of hexokinase in neuroblastoma cells.
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor (HIF)-1{alpha}.
Effect of methohexital on the relationship between hexokinase distribution and energy metabolism in neuroblastoma cells.
Effect of oxygen and glucose availability on the glycolytic rate in neuroblastoma cells under different conditions of culture.
Glycolytic enzymes from human neuroectodermal tumors of childhood.
Hexokinase 2 is a determinant of neuroblastoma metastasis.
Solubilization of hexokinase activity by an effect of thiopental on the mitochondrial membrane.
The regulation of apoptosis by the downstream regulatory element antagonistic modulator/potassium channel interacting Protein 3 (DREAM/KChIP3) through interactions with hexokinase I.
Neurodegenerative Diseases
TIGAR inclusion pathology is specific for Lewy body diseases.
Neuroendocrine Tumors
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
Gene Expression of Glucose Transporter 1 (GLUT1), Hexokinase 1 and Hexokinase 2 in Gastroenteropancreatic Neuroendocrine Tumors: Correlation with F-18-fluorodeoxyglucose Positron Emission Tomography and Cellular Proliferation.
Neuroinflammatory Diseases
Hexokinase 2-dependent hyperglycolysis driving microglial activation contributes to ischemic brain injury.
Newcastle Disease
Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells.
Non-alcoholic Fatty Liver Disease
Hepatic HKDC1 Expression Contributes to Liver Metabolism.
Obesity
Cardiac Transcriptome Analysis Reveals Nr4a1 Mediated Glucose Metabolism Dysregulation in Response to High-Fat Diet.
Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.
Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.
Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats.
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.
Obesity, Abdominal
Insulin sensitivity in growth hormone (GH)-deficient adults and effect of GH replacement therapy.
Optic Atrophy
Impact of Hypoxic Exercise Recovery on Skeletal Muscle Glycogen and Gene Expression.
Osteoarthritis
Increased hexokinase-2 as a novel biomarker for the diagnosis and correlating with disease severity in rheumatoid arthritis.
Osteosarcoma
LncRNA-SARCC sensitizes osteosarcoma to cisplatin through the miR-143-mediated glycolysis inhibition by targeting Hexokinase 2.
miR?185 regulates the growth of osteosarcoma cells via targeting Hexokinase 2.
PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma.
Ovarian Diseases
[Serum hexokinase activity in ovarian diseases]
Ovarian Neoplasms
Ciglitazone enhances ovarian cancer cell death via inhibition of glucose transporter-1.
Enhanced antitumor effects of follicle-stimulating hormone receptor-mediated hexokinase-2 depletion on ovarian cancer mediated by a shift in glucose metabolism.
Expression of hexokinase 2 in epithelial ovarian tumors and its clinical significance in serous ovarian cancer.
Ginsenoside 20(S)?Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells.
Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy.
Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades.
Inhibition of Lung Carcinoma A549 Cell Growth by Knockdown of Hexokinase 2 In Situ and In Vivo.
Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian Malignancy.
Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells.
Metabolic orchestration between cancer cells and tumor microenvironment as a co-evolutionary source of chemoresistance in ovarian cancer: a therapeutic implication.
miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells.
Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer.
[Hexokinase test in evaluating the treatment of ovarian cancer]
Pancreatic Neoplasms
Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis.
BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.
Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth.
Expression of glucose transporter-1, hexokinase-II, proliferating cell nuclear antigen and survival of patients with pancreatic cancer.
Glycolytic enzyme inhibitors affect pancreatic cancer survival by modulating its signaling and energetics.
Hexokinase 2 dimerization and interaction with voltage-dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer.
Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer.
Identification of genes differentially induced by hypoxia in pancreatic cancer cells.
Ikarugamycin inhibits pancreatic cancer cell glycolysis by targeting hexokinase 2.
MicroRNA-202 suppresses glycolysis of pancreatic cancer by targeting hexokinase 2.
MIR210HG regulates glycolysis, cell proliferation, and metastasis of pancreatic cancer cells through miR-125b-5p/HK2/PKM2 axis.
Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model.
Relationship between retention index in dual-phase (18)F-FDG PET, and hexokinase-II and glucose transporter-1 expression in pancreatic cancer.
Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor.
Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia.
Papilloma
A Case of Intraductal Papilloma of the Breast With High 18F-FDG Uptake on PET/CT.
Paraganglioma
Mitochondrial mutations in cancer.
Paralysis
Effects of growth medium, electrical stimulation and paralysis on various enzyme activities in cultured rat muscle cells. Comparison with activities in rat muscles in vivo.
Parasitemia
Malarial parasite hexokinase and hexokinase-dependent glutathione reduction in the Plasmodium falciparum-infected human erythrocyte.
Parkinson Disease
?-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease.
Hexokinase II gene transfer protects against neurodegeneration in the rotenone and MPTP mouse models of Parkinson's disease.
Periapical Periodontitis
iTRAQ-based quantitative analysis of alveolar bone resorption in rats with experimental periodontitis.
Periodontal Diseases
Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer.
Persistent Infection
Dual-Stage Picolinic Acid-Derived Inhibitors of Toxoplasma gondii.
Plague
[Use of hexokinase and creatine kinase systems for measurement of oxidative phosphorylation in the plague microbe]
Pneumonia
[Hexokinase and phosphofructokinase activity in acute pneumonia in children in the 1st year of life]
Pre-Eclampsia
Alterations in antioxidant system, mitochondrial biogenesis and autophagy in preeclamptic myometrium.
Preeclampsia inactivates glucose-6-phosphate dehydrogenase and impairs the redox status of erythrocytes and fetal endothelial cells.
Primary Myelofibrosis
Blood leucocyte enzymes. II. Activities at 8-9 a.m. in cells of normal subjects, chronic lymphatic leukaemia and chronic myeloid leukaemia patients.
Prostatic Hyperplasia
Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders.
Prostatic Neoplasms
Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer.
Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells.
Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer.
Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.
Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2.
MicroRNA-143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer.
New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Targeting hexokinase 2 in castration-resistant prostate cancer.
Targeting prostate cancer cell metabolism: impact of hexokinase and CPT-1 enzymes.
Zinc and p53 disrupt mitochondrial binding of HK2 by phosphorylating VDAC1.
Psoriasis
[The skin activity of hexokinase, glucokinase and phosphofructokinase in psoriasis patients]
Pulmonary Arterial Hypertension
Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure?
miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Metabolic enzymatic activities in the diaphragm of normal men and patients with moderate chronic obstructive pulmonary disease.
Metabolic enzymatic activities in the intercostal and serratus muscles and in the latissimus dorsi of middle-aged normal men and patients with moderate obstructive pulmonary disease.
Organization of metabolic pathways in vastus lateralis of patients with chronic obstructive pulmonary disease.
Pulmonary Edema
Maternal nicotine exposure during pregnancy and lactation: I. Effect on glycolysis in the lungs of the offspring.
pyruvate kinase deficiency
Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia.
Intracellular free magnesium and phosphorylated metabolites in hexokinase- and pyruvate kinase-deficient red cells measured using 31P-NMR spectroscopy.
Rectal Neoplasms
[Hexokinase test for determining precancerous diseases and cancer of the rectum and large intestine]
Renal Insufficiency, Chronic
Melatonin Protects Chronic Kidney Disease Mesenchymal Stem/Stromal Cells against Accumulation of Methylglyoxal via Modulation of Hexokinase-2 Expression.
[Effect of hemodialysis on erythrocyte acetylcholinesterase and adenosine triphosphatase activity in chronic renal insufficiency]
Reperfusion Injury
Hexokinase II and reperfusion injury: TAT-HK2 peptide impairs vascular function in Langendorff-perfused rat hearts.
Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia.
Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia-Reperfusion Injury.
Hydroxysafflor yellow A cardioprotection in ischemia-reperfusion (I/R) injury mainly via Akt/hexokinase II independent of ERK/GSK-3? pathway.
Mitochondrial hexokinase and cardioprotection of the intact heart.
sDR5-Fc inhibits macrophage M1 polarization by blocking the glycolysis.
Targeting Hexokinase II to mitochondria to modulate energy metabolism and reduce ischemia-reperfusion injury in heart.
The role of hexokinase in cardioprotection - mechanism and potential for translation.
Retinal Degeneration
Neurochemical studies on the inherited retinal degeneration of the rat. 3. Hexokinase, phosphofructokinase and atpase in the developing retina.
Whole exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa.
Retinal Neovascularization
MicroRNA-384-3p inhibits retinal neovascularization through targeting hexokinase 2 in mice with diabetic retinopathy.
Retinitis Pigmentosa
A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa.
Hexokinase 1 and retinitis pigmentosa: insights into the retina and the molecule.
Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection.
Whole exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa.
Retinoblastoma
Characterization of some glycolytic enzymes from human retina and retinoblastoma.
Structure, regulation, and biological functions of TIGAR and its role in diseases.
The double dealing of cyclin D1.
Rheumatic Fever
[Spectrum of hexokinase isoenzymes in the serum of patients with active rheumatic fever depending upon the clinical variant of disease]
Rickets
[Behavior of the hexokinase activity in rickets in man]
Sarcoma
Classical NF-?B Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2.
Enzyme changes induced in normal and malignant tissues with chemical agents. IV. Effect of alpha-peltatin on glucose utilization by sarcoma 37 and on the adenosinetriphosphatase, hexokinase, aldolase, and pyridine nucleotide levels of sarcoma 37.
FDG-PET/CT imaging findings of hepatic tumors and tumor-like lesions based on molecular background.
[A study of hexokinase isoenzymes in rat sarcoma M-1]
[Adsorption mechanism of hexokinase activity regulation in rat sarcoma M-1]
[Brain metabolism of sarcoma 45-bearing rats undergoing radiation and the effect of hyperthermia on the tumor]
[Hexokinase, aspartate and alanine aminotransferase activity in transplanted rat sarcomas]
[Subcellular localization, isoenzyme spectrum and properties of hexokinase from sarcoma M-1]
[The characteristics of sarcoma M-1 in rats]
Sarcoma 37
Enzyme changes induced in normal and malignant tissues with chemical agents. IV. Effect of alpha-peltatin on glucose utilization by sarcoma 37 and on the adenosinetriphosphatase, hexokinase, aldolase, and pyridine nucleotide levels of sarcoma 37.
Sarcoma, Avian
Inhibition of hexokinase and protein kinase activities of tumor cells by a chloromethyl ketone derivative of lactic acid.
Metabolism of 2-[18F]fluoro-2-deoxyglucose in tumor-bearing rats: chromatographic and enzymatic studies.
Transport and phosphorylation of hexoses in normal and Rous sarcoma virus-transformed chick embryo fibroblasts.
Schistosomiasis
Schistosoma mansoni hexokinase: cDNA cloning and immunogenicity studies.
Scleroderma, Systemic
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Scurvy
Effect of scurvy on hexokinase activity of tissues of guinea pigs.
Seizures
Hexokinase redistribution in vivo.
Neonatal seizures in monkeys and rabbits: brain glucose depletion in the face of normoglycemia, prevention by glucose loads.
Sepsis
Enhanced glycolytic metabolism contributes to cardiac dysfunction in polymicrobial sepsis.
MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis.
Sleep Deprivation
Rapid eye movement sleep-deprivation-induced changes in glucose metabolic enzymes in rat brain.
Small Cell Lung Carcinoma
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Squamous Cell Carcinoma of Head and Neck
Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma.
Hexokinase-II expression in untreated oral squamous cell carcinoma: comparison with FDG PET imaging.
HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer.
LncRNA loc285194 inhibits tumor growth of laryngeal squamous cell carcinoma cells by downregulating hexokinase 2.
MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2.
miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma.
MiR-125b-5p suppressed the glycolysis of laryngeal squamous cell carcinoma by down-regulating hexokinase-2.
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis.
Starvation
Age-dependent glycolysis and gluconeogenesis enzyme activities in starved-refed rats.
Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans.
Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer.
dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth.
Effects of glucose refeeding and glibenclamide treatment on glucokinase and GLUT2 gene expression in pancreatic B-cells and liver from rats.
Effects of phorbol, dexamethasone and starvation on 3-O-methyl-D-glucose transport by rat thymocytes. Modulation of transport by altered trans effects.
Endoplasmic Reticulum Stress Sensor IRE1? Enhances IL-23 Expression by Human Dendritic Cells.
Fuel utilization in colonocytes of the rat.
Glucose dehydrogenase, glucose-6-phosphate dehydrogenase and hexokinase in liver of rainbow trout (Salmo gairdneri). Effects of starvation and temperature variations.
Glucose phosphorylation and dephosphorylation in chicken liver.
In situ activities of hexokinase and fructokinase in relation to phosphorylation status of root meristem cells of Vicia faba during reactivation from sugar starvation
In situ activities of hexokinase and fructokinase in relation to phosphorylation status of root meristem cells of Vicia faba during reactivation from sugar starvation.
Insulin and glucagon family peptides in relation to activities of hepatic hexokinase and other enzymes in fed and starved Atlantic salmon (Salmo salar) and cod (Gadus morhua).
Liver hexokinase activity in rats adapted to intermittent starvation.
Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by lungs of the rat.
Protein metabolism during nutrient deprivation and refeeding of neonatal heart cells.
Sucrose transport is inhibited by okadaic acid during regeneration of sugar-starved Vicia faba root meristem cells.
Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics.
[Activity of hexokinase and glucose-6-phosphate dehydrogenase in hemopoietic cells of the bone marrow in normal rabbits and after hydrocortisone administration during starvation and alloxan diabetes]
[Activity, hexokinase isoenzyme spectrum and various factors of their regulation in liver and skeletal muscles of young piglets]
Stomach Neoplasms
3-Bromopyruvate and sodium citrate induce apoptosis in human gastric cancer cell line MGC-803 by inhibiting glycolysis and promoting mitochondria-regulated apoptosis pathway.
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target.
Helicobacter pylori CagA Protein Attenuates 5-Fu Sensitivity of Gastric Cancer Cells Through Upregulating Cellular Glucose Metabolism.
Licochalcone A suppresses hexokinase 2-mediated tumor glycolysis in gastric cancer via downregulation of the Akt signaling pathway.
MicroRNA-181b inhibits glycolysis in gastric cancer cells via targeting hexokinase 2 gene.
Physicochemical properties and isoenzyme composition of hexokinase from normal and malignant human tissues.
Quantitative Proteomics Analysis Revealed the Potential Role of lncRNA Ftx in Promoting Gastric Cancer Progression.
SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis.
[Clinical significance of determining hexokinase, lactate dehydrogenase and its isoenzymes in stomach cancer]
[Hexokinase activity in the blood of stomach cancer patients]
[Hexokinase and lactate dehydrogenase activity, lactic and pyruvic acid content of erythrocytes and acid-base equilibrium in stomach cancer patients after radical operations]
[Hexokinase in biopsy material from gastric neoplasms]
Stomach Ulcer
[Assessment of the findings of fibrogastroscopy with gastrobiopsy and determination of hexokinase activity in the serum and gastric juice of stomach ulcer patients]
Thalassemia
Glucose 6-phosphate dehydrogenase, hexokinase activities and ATP levels as a function of cell density in thalassemia and iron deficiency anemia.
Thrombosis
Human coronary thrombus formation is associated with degree of plaque disruption and expression of tissue factor and hexokinase II.
Thymoma
Expression of cardiac insulin signalling genes and proteins in rats fed a high-sucrose diet: effect of bilberry anthocyanin extract.
Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma.
Thyroid Cancer, Papillary
Glycolysis-related protein expression in thyroid cancer.
Thyroid Carcinoma, Anaplastic
Combined RNA interference of hexokinase II and (131)I-sodium iodide symporter gene therapy for anaplastic thyroid carcinoma.
Glycolytic inhibition with 3-bromopyruvate suppresses tumor growth and improves survival in a murine model of anaplastic thyroid cancer.
Hexokinase isoenzymes from anaplastic and differentiated medullary thyroid carcinoma in the rat.
Thyroid Diseases
[Diagnostic value of the determination of serum hexokinase activity in thyroid cancer and autoimmune thyroiditis]
Thyroid Neoplasms
Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.
Hexokinase isoenzymes from anaplastic and differentiated medullary thyroid carcinoma in the rat.
Relationship between biological marker expression and fluorine-18 fluorodeoxyglucose uptake in incidentally detected thyroid cancer.
[18F]fluorodeoxyglucose uptake in recurrent thyroid cancer is related to hexokinase i expression in the primary tumor.
[Catalytic properties and isoenzyme composition of hexokinase in thyroid gland normal and neoplastic tissue]
[Diagnostic value of the determination of serum hexokinase activity in thyroid cancer and autoimmune thyroiditis]
Thyroid Nodule
Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.
Thyroiditis, Autoimmune
[Diagnostic value of the determination of serum hexokinase activity in thyroid cancer and autoimmune thyroiditis]
Thyrotoxicosis
[Effect of thyroxine on oxidative enzymatic activity in the rat aorta]
Triple Negative Breast Neoplasms
Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.
Trypanosomiasis, African
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
Uremia
Muscle glucose content and hexokinase activity in patients with chronic uremia.
[Muscle hexokinase and phosphofructokinase activity in patients with chronic uremia]
[The physiopathologic bases of the neurotoxicity of phosphorus chelating agents containing soluble aluminum salts in patients with renal insufficiency]
Urinary Bladder Neoplasms
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis.
Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway.
Proteomic analysis of bladder cancer by iTRAQ after Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene treatment.
Single-Cell Sequencing-Enabled Hexokinase 2 Assay for Noninvasive Bladder Cancer Diagnosis and Screening by Detecting Rare Malignant Cells in Urine.
Uterine Cervical Neoplasms
Correlation Between FDG Uptake by PET/CT and the Expressions of Glucose Transporter Type 1 and Hexokinase II in Cervical Cancer.
Hexokinase 2 Promotes Cell Growth and Tumor Formation Through the Raf/MEK/ERK Signaling Pathway in Cervical Cancer.
Targeting hexokinase 2 inhibition promotes radiosensitization in HPV16 E7-induced cervical cancer and suppresses tumor growth.
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
[On the use and clinical importance of the hexokinase test in diagnosis of cancer of the cervix uteri]
Uterine Neoplasms
Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase, phosphoglucomutase and lactate dehydrogenase in uterine cancer.
[Hexokinase isozyme in human uterine cancer]
Virus Diseases
ARGONAUTE 2 increases rice susceptibility to rice black-streaked dwarf virus infection by epigenetically regulating HEXOKINASE 1 expression.
Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.
Hexokinase activity as marker to assess time of harvest of foot-and-mouth disease virus in BHK(21) Cl(13) cell cultures.
Hexokinase II may be dispensable for CD4 T cell responses against a virus infection.
Mitochondrial induced T cell apoptosis and aberrant myeloid metabolic programs define distinct immune cell subsets during acute and recovered SARS-CoV-2 infection.
Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.
[Biochemical study of experimental West Nile virus infections; behavior of succinodehydrogenase, asparticketoglutaric transaminase, adenylpyrophosphatase, rhodanese and hexokinase activity in the brain and liver.]
[Hexokinase activity of the brain and myocardium in experimental encephalomyocardial virus infection.]
Vitamin K Deficiency
[Kinetic characteristics of creatine kinase and hexokinase from rat skeletal muscles during dietary deficit of vitamin K and administration of pelentane]
[Skeletal muscle phosphorylase and hexokinase activity in vitamin K deficiency and the effect of several 6-hydroxychromane derivatives on changes in hexokinase activity]