Information on EC 2.6.1.87 - UDP-4-amino-4-deoxy-L-arabinose aminotransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.6.1.87
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RECOMMENDED NAME
GeneOntology No.
UDP-4-amino-4-deoxy-L-arabinose aminotransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Amino sugar and nucleotide sugar metabolism
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polymyxin resistance
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SYSTEMATIC NAME
IUBMB Comments
UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase
A pyridoxal 5'-phosphate enzyme.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Uniprot
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate
UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate
UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
the pyridoxal phosphate is converted to the pyridoxamine form in the presence of excess glutamate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
PDB
SCOP
CATH
ORGANISM
UNIPROT
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
hanging drop vapor diffusion method, high-resolution crystal structures are solved for two native forms and one covalently inhibited form of Salmonella typhimurium ArnB (crystal structure of ArnB aminotransferase with pyridomine 5'-phosphate, crystal structure of ArnB transferase with pyridoxal 5'-phosphate, crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5'-phosphate)
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overexpressed using a T7lac promoter-driven construct, hexahistidine-tagged fusion protein
Show AA Sequence (1663 entries)
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