Information on EC 2.6.1.63 - kynurenine-glyoxylate transaminase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.6.1.63
-
RECOMMENDED NAME
GeneOntology No.
kynurenine-glyoxylate transaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
show the reaction diagram
acts, more slowly, on L-phenylalanine, L-histidine and L-tyrosine
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-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-kynurenine:glyoxylate aminotransferase (cyclizing)
Acts, more slowly, on L-phenylalanine, L-histidine and L-tyrosine.
CAS REGISTRY NUMBER
COMMENTARY hide
74506-33-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Donryu strain
-
-
Manually annotated by BRENDA team
Donryu strain
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-hydroxytryptophan + glyoxylate
3-(5-hydroxyindole)-2-oxopropanoate + glycine
show the reaction diagram
histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
show the reaction diagram
L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
show the reaction diagram
L-kynurenine + 4-methylsulfanyl-2-oxobutanoate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine
show the reaction diagram
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
show the reaction diagram
L-kynurenine + hydroxypyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine
show the reaction diagram
L-kynurenine + pyruvate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
show the reaction diagram
phenylalanine + glyoxylate
phenylpyruvate + glycine
show the reaction diagram
tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
show the reaction diagram
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-kynurenine + glyoxylate
4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
hydroxylamine
Isonicotinic hydrazide
Semicarbazide
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.4 - 0.5
glyoxylate
1.2 - 1.5
L-kynurenine
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 8.5
additional information
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70
-
t1/2: 25 min
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5’-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 4 weeks
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-20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5’-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 7 weeks
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0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5’-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, 2 weeks
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0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal phosphate, 5 mM mercaptoethanol, 20% glycerol, 3 weeks
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE