Information on EC 2.6.1.60 - aromatic-amino-acid-glyoxylate transaminase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.6.1.60
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RECOMMENDED NAME
GeneOntology No.
aromatic-amino-acid-glyoxylate transaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an aromatic amino acid + glyoxylate = an aromatic oxo acid + glycine
show the reaction diagram
phenylalanine, kynurenine, tyrosine and histidine can act as amino donors, glyoxylate, pyruvate and hydroxypyruvate can act as amino acid acceptors
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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SYSTEMATIC NAME
IUBMB Comments
aromatic-amino-acid:glyoxylate aminotransferase
Phenylalanine, kynurenine, tyrosine and histidine can act as amino donors; glyoxylate, pyruvate and hydroxypyruvate can act as amino acceptors.
CAS REGISTRY NUMBER
COMMENTARY hide
67185-76-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Blyth monkey
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Manually annotated by BRENDA team
distribution among mammals
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-hydroxytryptophan + glyoxylate
3-(5-hydroxyindole)-2-oxopropanoate + glycine
show the reaction diagram
an aromatic amino acid + glyoxylate
an aromatic oxo acid + glycine
show the reaction diagram
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-
-
-
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asparagine + glyoxylate
2-oxosuccinamate + glycine
show the reaction diagram
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less efficient amino group donor than L-phenylalanine
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-
?
glutamine + glyoxylate
4-carbamoyl-2-oxobutanoate + glycine
show the reaction diagram
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less efficient amino group donor than L-phenylalanine
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-
?
isoleucine + glyoxylate
3-methyl-2-oxopentanoate + glycine
show the reaction diagram
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poor substrate
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-
?
L-glutamate + glyoxylate
2-oxoglutarate + glycine
show the reaction diagram
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poor substrate
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-
?
L-histidine + glyoxylate
3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine
show the reaction diagram
L-kynurenine + glyoxylate
3-(2-aminophenyl-)2,4-dioxobutanoate + glycine
show the reaction diagram
L-leucine + glyoxylate
4-methyl-2-oxopentanoate + glycine
show the reaction diagram
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less efficient amino group donor than L-phenylalanine
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-
?
L-methionine + glyoxylate
4-methylsulfanyl-2-oxobutanoate + glycine
show the reaction diagram
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less efficient amino group donor than L-phenylalanine
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L-phenylalanine + 2-oxo-4-methylthiobutyrate
phenylpyruvate + L-methionine
show the reaction diagram
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
show the reaction diagram
L-phenylalanine + glyoxylate
phenylpyruvate + glycine
show the reaction diagram
L-phenylalanine + hydroxypyruvate
phenylpyruvate + L-serine
show the reaction diagram
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
show the reaction diagram
L-serine + glyoxylate
3-hydroxy-2-oxopropanoate + glycine
show the reaction diagram
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less efficient amino group donor than L-phenylalanine
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tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
show the reaction diagram
tyrosine + glyoxylate
3-(4-hydroxyphenyl)-2-oxopropanoate + glycine
show the reaction diagram
valine + glyoxylate
3-methyl-2-oxobutanoate + glycine
show the reaction diagram
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poor substrate
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-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
an aromatic amino acid + glyoxylate
an aromatic oxo acid + glycine
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
hydroxylamine
Isonicotinic hydrazide
Semicarbazide
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.1
alanine
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cosubstrate L-glyoxylate, 37°C
0.07 - 0.5
glyoxylate
2.7
histidine
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cosubstrate pyruvate, 37°C
1.2 - 1.5
L-kynurenine
2.6
phenylalanine
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cosubstrate pyruvate, 37°C
0.07 - 5.1
pyruvate
16
serine
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cosubstrate pyruvate, 37°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.105
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pH 7.5, 37°C
0.223
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pH 7.5, 37°C
12.9
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substrates histidine + pyruvate, 37°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 8.5
additional information
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
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subcellular distribution distribution in different mammalia
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Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, at least 4 weeks
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-20°C, at least 6 weeks
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-20°C, at least 7 weeks
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0-4°C, 2 weeks with little or no loss of activity
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0-4°C, 3 weeks with little or no loss of activity respectively
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0-5°C, 2 weeks with little or no loss of activity
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE