Information on EC 2.6.1.56 - 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase

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The expected taxonomic range for this enzyme is: Streptomyces

EC NUMBER
COMMENTARY hide
2.6.1.56
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RECOMMENDED NAME
GeneOntology No.
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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streptomycin biosynthesis
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Streptomycin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase
L-Glutamate and L-glutamine can also act as amino donors.
CAS REGISTRY NUMBER
COMMENTARY hide
57127-19-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Streptomyces hygroscopicus subsp. glebosus
ATCC 14607
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Manually annotated by BRENDA team
ATCC 11062
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Manually annotated by BRENDA team
ATCC 12475
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Manually annotated by BRENDA team
ATCC 23265
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
show the reaction diagram
L-glutamate + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
5-amino-2,5-dioxopentanoic acid + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
show the reaction diagram
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r
L-glutamine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
alpha-ketoglutaramate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
show the reaction diagram
additional information
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D-amino acids are no substrates, also catalyzes transamination between 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol and 1D-1-guanidino-1-deoxy-3-keto-scyllo inositol
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol
pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55
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inactivated by heating for 5 min
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
unstable to dialysis in absence of pyridoxal 5'-phosphate, pyruvate spares the pyridoxal 5'-phosphate requirement during dialysis
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