Information on EC 2.6.1.55 - taurine-2-oxoglutarate transaminase

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The expected taxonomic range for this enzyme is: Chromohalobacter salexigens DSM 3043

EC NUMBER
COMMENTARY hide
2.6.1.55
-
RECOMMENDED NAME
GeneOntology No.
taurine-2-oxoglutarate transaminase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
taurine + 2-oxoglutarate = 2-sulfoacetaldehyde + L-glutamate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
taurine degradation III
-
-
beta-Alanine metabolism
-
-
Taurine and hypotaurine metabolism
-
-
Metabolic pathways
-
-
SYSTEMATIC NAME
IUBMB Comments
taurine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein. Also acts on D,L-3-amino-isobutanoate, beta-alanine and 3-aminopropanesulfonate. Involved in the microbial utilization of beta-alanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9076-52-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Achromobacter polymorph
KR B-88
-
-
Manually annotated by BRENDA team
Achromobacter polymorph KR B-88
KR B-88
-
-
Manually annotated by BRENDA team
Achromobacter superficialis
Achromobacter superficialis ICR-B-89
ICR-B-89
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-aminopropanesulfonate + 2-oxoglutarate
2-oxopropanesulfonate + L-glutamate
show the reaction diagram
4-aminobutyrate + 2-oxoglutarate
L-glutamate + acetaldehyde + sulfite
show the reaction diagram
Achromobacter superficialis
-
60% of the activity with taurine
-
-
?
beta-alanine + 2-oxoglutarate
3-oxopropanoate + L-glutamate
show the reaction diagram
DL-3-aminobutyrate + 2-oxoglutarate
3-oxobutyrate + L-glutamate
show the reaction diagram
DL-3-aminoisobutyrate + 2-oxoglutarate
2-methyl-3-oxopropanoate + L-glutamate
show the reaction diagram
hypotaurine + 2-oxoglutarate
2-oxoethanesulfinic acid + L-glutamate
show the reaction diagram
taurine + 2-oxoglutarate
sulfoacetaldehyde + L-glutamate
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-Methyl-2-benzothiazolone hydrazone hydrochloride
Achromobacter superficialis
-
weak inhibition
D-cycloserine
Achromobacter superficialis
-
0.5 mM; 20% inhibition
HgCl2
hydroxylamine
L-Cycloserine
phenylhydrazine
Achromobacter superficialis
-
0.5 mM, 17% inhibition
Semicarbazide
Achromobacter superficialis
-
0.5 mM, 21% inhibition
additional information
Achromobacter superficialis
-
not inhibited by p-chloromercuribenzoate, monoiodoacetic acid, D-penicillamine, L-penicillamine and EDTA
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11
2-oxoglutarate
Achromobacter superficialis
-
pH 8.0, 37C, cosubstrate DL-3-aminoisobutyrate
17
beta-Alanine
16
Hypotaurine
12
taurine
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.519
Achromobacter superficialis
-
-
5.19
Achromobacter superficialis
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8 - 8
Achromobacter superficialis
-
-
8
Achromobacter superficialis
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
Achromobacter superficialis
-
assay at
60
Achromobacter superficialis
-
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
156000
Achromobacter superficialis
-
sedimentation equilibrium
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
-
Achromobacter superficialis
-
ammonium sulfate at pH 7.0-7.6, crystals appear after 2-3 days
Achromobacter superficialis
-
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 9
Achromobacter superficialis
-
60C, 10 min, stable
636679
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60
Achromobacter superficialis
-
pH 6.0-9.0, 10 min, stable
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
treatment with ammonium sulfate during purification leads to a significant loss of activity
Achromobacter superficialis
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0-5C, crystalline enzyme in 10 mM potassium phosphate buffer, pH 7.0, 60% saturation of ammonium sulfate, 100 mM pyridoxal 5'-phosphate, 0.01% 2-mercaptoethanol, several months, no loss of activity
Achromobacter superficialis
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
-
Achromobacter superficialis
-
DEAE-cellulose, Sephadex G-150, hydroxylapatite, ammonium sulfate, Sephadex g-150, crystalization
Achromobacter superficialis
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