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(2-aminophenyl)alanine + 2-oxoglutarate
3-(4-aminophenyl)-2-oxopropanoate + L-glutamate
-
10% of the activity that with L-tyrosine
-
?
(3-fluorophenyl)alanine + 2-oxoglutarate
3-(3-fluorophenyl)-2-oxopropanoate + L-glutamate
-
4% of the activity that with L-tyrosine
-
?
(4-chlorophenyl)alanine + 2-oxoglutarate
3-(3-chlorophenyl)-2-oxopropanoate + L-glutamate
-
17% of the activity with L-tyrosine
-
?
(4-fluorophenyl)alanine + 2-oxoglutarate
3-(4-fluorophenyl)-2-oxopropanoate + L-glutamate
-
7.9% of the activity that with L-tyrosine
-
?
(R)-3-amino-5-methyl-hexanoic acid + 2-oxoglutarate
?
relative activity: 48%
-
-
?
(S)-beta-phenylalanine + 2-oxoglutarate
3-oxo-3-phenylpropionic acid + L-glutamate
relative activity: 100%
-
-
?
(S)-beta-phenylalanine + pyruvate
3-oxo-3-phenylpropionic acid + L-alanine
the activity of VpAT with pyruvate is 85% of that with alpha-ketoglutarate as the amino acceptor
-
-
?
2-oxoglutarate + L-phenylalanine
L-glutamate + phenylpyruvate
-
-
-
?
3,4-dihydroxyphenylalanine + 2-oxoglutarate
3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
L-tyrosine + 2-oxoglutarate
-
-
-
r
3-aminotyrosine + 2-oxoglutarate
3-(3-amino-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
16% of the activity than with L-tyrosine
-
?
3-iodotyrosine + 2-oxoglutarate
3-(4-hydroxy-3-iodophenyl)-2-oxopropanoate + L-glutamate
3-methoxytyrosine + 2-oxoglutarate
3-(3-methoxy-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
22% of the activity with L-tyrosine
-
?
4-hydroxyphenylpyruvate + L-aspartate
L-tyrosine + oxaloacetate
-
35% of the activity with L-glutamate
-
r
4-hydroxyphenylpyruvate + L-glutamate
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-phenylalanine
L-glutamate + phenylpyruvate
-
-
-
?
4-methylthio-2-oxobutanoate + L-glutamate
?
-
-
-
r
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
L-alanine + 2-oxoisocaproate
pyruvate + 2-aminoisocaproate
-
-
-
?
L-arginine + 2-oxoglutarate
?
-
-
-
r
L-asparagine + 2-oxoglutarate
2-oxosuccinamate + L-glutamate
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
L-cysteine + 2-oxoglutarate
3-mercapto-2-oxopropanoate + L-glutamate
L-ethionine + 2-oxoglutarate
4-ethylsulfanyl-2-oxobutanoate + L-glutamate
-
17% of the activity than with L-tyrosine
-
?
L-glutamate + 4-hydroxyphenylpyruvate
2-oxoglutarate + L-tyrosine
L-glutamate + 4-hydroxyphenylpyruvate
L-tyrosine + 2-oxoglutarate
-
-
-
-
?
L-glutamate + oxaloacetate
?
-
-
-
-
r
L-glutamate + oxaloacetate
L-aspartate + 2-oxoglutarate
-
-
-
-
?
L-glutamate + phenylpyruvate
2-oxoglutarate + L-phenylalanine
L-glutamate + pyruvate
L-alanine + 2-oxoglutarate
-
-
-
-
?
L-glutamine + 2-oxoglutarate
5-amino-2,5-dioxopentanoic acid + L-glutamate
-
-
-
r
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + L-glutamate
-
-
-
r
L-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoic acid + L-glutamate
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
L-phenylalanine + 2-oxoglutarate
L-glutamate + phenylpyruvate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
-
-
r
L-serine + 2-oxoglutarate
3-hydroxy-2-oxopropanoic acid + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glutamate
L-tryptophan + oxaloacetate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glycine
-
-
-
-
?
L-tryptophan + pyruvate
3-(1H-indol-3-yl)-2-oxopropanoate + L-alanine
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
L-tyrosine + 2-oxohexanoate
3-(4-hydroxyphenyl)-2-oxopropanoate + (2S)-2-aminohexanoate
-
-
-
-
?
L-tyrosine + 2-oxopentanoate
3-(4-hydroxyphenyl)-2-oxopropanoate + (2S)-2-aminopentanoate
relative activity compared to 2-oxoglutarate: 3%
-
-
?
L-tyrosine + 4-methylthio-2-oxobutanoate
?
-
-
-
r
L-tyrosine + alpha-ketomethiobutyrate
?
-
-
-
r
L-tyrosine + oxaloacetate
4-hydroxyphenylpyruvate + L-aspartate
L-tyrosine + oxaloacetate
?
relative activity compared to 2-oxoglutarate: 75%
-
-
?
L-tyrosine + phenylpyruvate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-phenylalanine
L-tyrosine + phenylpyruvate
4-hydroxyphenylpyruvate + L-phenylalanine
L-tyrosine + prephenate
?
relative activity compared to 2-oxoglutarate: 23%
-
-
?
L-tyrosine + pyruvate
4-hydroxyphenylpyruvate + L-alanine
L-tyrosine + pyruvate
?
relative activity compared to 2-oxoglutarate: 40%
-
-
?
oxaloacetate + L-glutamate
L-aspartate + 2-oxoglutarate
-
-
-
r
phenylpyruvate + L-glutamate
2-oxoglutarate + L-phenylalanine
-
-
-
r
rac-2-fluoro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 15%
-
-
?
rac-2-methyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 5%
-
-
?
rac-3-bromo-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 53%
-
-
?
rac-3-chloro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 56%
-
-
?
rac-3-fluoro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 48%
-
-
?
rac-3-methyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 54%
-
-
?
rac-4-bromo-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 62%
-
-
?
rac-4-ethyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 134%
-
-
?
rac-4-fluoro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 87%
-
-
?
rac-4-iso-propyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 61%
-
-
?
rac-4-methyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 100%
-
-
?
rac-4-nitro-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 32%
-
-
?
rac-4-nitro-hydroxy-phenylalanine + 2-oxoglutarate
?
relative activity: 61%
-
-
?
rac-4-propyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 126%
-
-
?
rac-4-trifluoromethyl-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 73%
-
-
?
rac-beta-leucine + 2-oxoglutarate
?
relative activity: 38%
-
-
?
rac-beta-phenylalanine + 2-oxoglutarate
?
relative activity: 100%
-
-
?
tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
additional information
?
-
3,4-dihydroxyphenylalanine + 2-oxoglutarate
3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
-
-
-
?
3,4-dihydroxyphenylalanine + 2-oxoglutarate
3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
-
85% of the activity than with L-tyrosine
-
?
3-iodotyrosine + 2-oxoglutarate
3-(4-hydroxy-3-iodophenyl)-2-oxopropanoate + L-glutamate
-
as effective as L-tyrosine
-
?
3-iodotyrosine + 2-oxoglutarate
3-(4-hydroxy-3-iodophenyl)-2-oxopropanoate + L-glutamate
-
84% of the activity than with L-tyrosine
-
?
4-hydroxyphenylpyruvate + L-glutamate
L-tyrosine + 2-oxoglutarate
-
-
-
r
4-hydroxyphenylpyruvate + L-glutamate
L-tyrosine + 2-oxoglutarate
favoured direction of reaction for isoform TAT2
-
-
r
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
-
-
-
r
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
-
-
-
?
L-asparagine + 2-oxoglutarate
2-oxosuccinamate + L-glutamate
-
-
-
r
L-asparagine + 2-oxoglutarate
2-oxosuccinamate + L-glutamate
-
15% of the activity with L-tyrosine
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
isoenzymes TAT-2 and TAT-3, best substrate for isoenzyme TAT-3
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
-
higher activity than with L-tyrosine
-
?
L-cysteine + 2-oxoglutarate
3-mercapto-2-oxopropanoate + L-glutamate
-
-
-
r
L-cysteine + 2-oxoglutarate
3-mercapto-2-oxopropanoate + L-glutamate
-
higher activity than with L-tyrosine
-
?
L-glutamate + 4-hydroxyphenylpyruvate
2-oxoglutarate + L-tyrosine
-
-
-
-
?
L-glutamate + 4-hydroxyphenylpyruvate
2-oxoglutarate + L-tyrosine
-
-
-
-
r
L-glutamate + 4-hydroxyphenylpyruvate
2-oxoglutarate + L-tyrosine
-
-
-
?
L-glutamate + phenylpyruvate
2-oxoglutarate + L-phenylalanine
-
-
-
r
L-glutamate + phenylpyruvate
2-oxoglutarate + L-phenylalanine
-
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
r
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
-
-
-
?
L-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
20% of the activity than with L-tyrosine
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
-
-
-
r
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
-
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
-
r
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
-
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
lower activity than with L-tyrosine
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
higher rate than with L-tyrosine
-
?
L-phenylalanine + 2-oxoglutarate
phenylpyruvate + L-glutamate
-
no activity
-
?
L-tryptophan + 2-oxoglutarate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glutamate
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glutamate
-
-
-
-
r
L-tryptophan + pyruvate
3-(1H-indol-3-yl)-2-oxopropanoate + L-alanine
-
-
-
r
L-tryptophan + pyruvate
3-(1H-indol-3-yl)-2-oxopropanoate + L-alanine
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
best substrate
-
-
r
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
highly specific for: L-tyrosine
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
isoenzymes TAT-1, TAT-2 and TAT-3 show a pronounced preference for L-tyrosine over other aromatic amino acids
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
isoenzyme TAT-1: oxaloacetate and 2-oxoglutarate utilized equally well as amino acceptor, isoenzyme TAT-2: oxaloacetate is most effective, isoenzyme TAT-3: 2-oxoglutarate is most effective
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
first step in tyrosine pathway leading to the formation of rosmarinic acid (alpha-O-caffeoyl-3,4-dihydroxyphenyllactic acid)
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
best substrate and favoured direction of reaction for isoform TAT1
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
specific for 2-oxoglutarate as the amino group acceptor
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
r
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
maximal activity with L-tyrosine
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
A0A163U8E7
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
highly specific for: L-tyrosine
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + 2-oxoglutarate
4-hydroxyphenylpyruvate + L-glutamate
-
-
-
?
L-tyrosine + oxaloacetate
4-hydroxyphenylpyruvate + L-aspartate
-
-
-
?
L-tyrosine + oxaloacetate
4-hydroxyphenylpyruvate + L-aspartate
-
-
-
r
L-tyrosine + oxaloacetate
4-hydroxyphenylpyruvate + L-aspartate
-
-
-
?
L-tyrosine + oxaloacetate
4-hydroxyphenylpyruvate + L-aspartate
-
-
-
-
r
L-tyrosine + oxaloacetate
4-hydroxyphenylpyruvate + L-aspartate
-
no activity
-
?
L-tyrosine + oxaloacetate
4-hydroxyphenylpyruvate + L-aspartate
-
-
-
r
L-tyrosine + oxaloacetate
4-hydroxyphenylpyruvate + L-aspartate
-
no activity
-
?
L-tyrosine + phenylpyruvate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-phenylalanine
-
-
-
r
L-tyrosine + phenylpyruvate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-phenylalanine
-
-
-
-
?
L-tyrosine + phenylpyruvate
4-hydroxyphenylpyruvate + L-phenylalanine
-
-
-
r
L-tyrosine + phenylpyruvate
4-hydroxyphenylpyruvate + L-phenylalanine
-
-
-
-
r
L-tyrosine + pyruvate
4-hydroxyphenylpyruvate + L-alanine
-
-
-
?
L-tyrosine + pyruvate
4-hydroxyphenylpyruvate + L-alanine
-
-
-
r
L-tyrosine + pyruvate
4-hydroxyphenylpyruvate + L-alanine
-
-
-
-
r
L-tyrosine + pyruvate
4-hydroxyphenylpyruvate + L-alanine
-
-
-
?
tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
?
tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
62% of the activity than with L-tyrosine
-
?
tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
no activity
-
?
tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
-
-
-
-
?
additional information
?
-
isoform TAT1 shows no activity with oxaloacetate, L-Ala, L-Ser, L-Cys, L-Asp, L-Asn, L-Gln, and L-Arg
-
-
-
additional information
?
-
isoform TAT1 shows no activity with oxaloacetate, L-Ala, L-Ser, L-Cys, L-Asp, L-Asn, L-Gln, and L-Arg
-
-
-
additional information
?
-
-
isoform TAT1 shows no activity with oxaloacetate, L-Ala, L-Ser, L-Cys, L-Asp, L-Asn, L-Gln, and L-Arg
-
-
-
additional information
?
-
-
no detectable transamination of aspartate or other cosubstrates
-
-
?
additional information
?
-
the enzyme exhibits no activity with L-tyrosine and 2-oxoglutarate
-
-
-
additional information
?
-
-
the enzyme exhibits no activity with L-tyrosine and 2-oxoglutarate
-
-
-
additional information
?
-
-
leishmanial TAT is deprived of ALAT activity and exhibits undetectable activity towards leucine, glutamine and cysteine, leishmanial TAT reveals undetectable activity when other 2-oxoacids such as 2-oxoglutarate, glyoxylate, 2-oxoisovalerate and 2-oxoisocaproate are assayed at a concentration up to 10 mM, the leishmanial enzyme displays almost identical preference for 2-oxo-4-methylthiobutyrate, pyruvate and 2-oxobutyrate
-
-
?
additional information
?
-
activities with glutamate, methionine and leucine do not exceed 13% of the activity with tyrosine. Only phenylpyruvate and 2-oxoglutarate effectively serve as acceptors, and no activity is detected with prephenate
-
-
?
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1.5
(S)-beta-phenylalanine
pH 7.6, 30°C
0.13
2-oxo-3-phenylpropanoate
pH 8.2, 30°C
0.19 - 3300
2-oxoglutarate
7.3
2-Oxohexanoate
-
pH 7.0, 38°C
0.3 - 20.4
2-oxoisocaproate
26
3,4-dihydroxyphenylalanine
-
pH 7.9, 37°C
0.22
3-(4-hydroxyphenyl)-2-oxopropanoate
pH 8.2, 30°C
0.41 - 10.1
4-hydroxyphenylpyruvate
0.74 - 3.46
4-methylthio-2-oxobutanoate
0.8103
alpha-ketomethiobutyrate
with L-tyrosine as cosubstrate, at pH 8.0 and 37°C
0.84 - 17.9
L-phenylalanine
5.055 - 8.14
L-tryptophan
1.82 - 56.13
oxaloacetate
1.2 - 580
p-hydroxyphenylpyruvate
80
phenylalanine
-
pH 7.9, 37°C
0.455 - 3.9
phenylpyruvate
additional information
additional information
-
0.19
2-oxoglutarate
pH 8.2, 30°C
0.25
2-oxoglutarate
-
pH 7.6, 37°C
0.3
2-oxoglutarate
pH 7.6, 30°C
0.35
2-oxoglutarate
-
pH 8.5, 30°C
0.35
2-oxoglutarate
mutant R315K, pH 7.5, 37°C
0.4
2-oxoglutarate
wild-type, pH 7.5, 37°C
0.7
2-oxoglutarate
-
pH 7.2, 37°C
0.9
2-oxoglutarate
-
pH 7.6, 37°C, enzyme form I
1
2-oxoglutarate
-
pH 7.6, 37°C, enzyme form III
1.1
2-oxoglutarate
-
pH 7.6, 37°C, enzyme form II
1.2
2-oxoglutarate
-
pH 7.6, 37°C, enzyme form IV
1.8
2-oxoglutarate
-
pH 7.0, 38°C
1.8
2-oxoglutarate
cosubstrate phenylalanine, pH 10.0, 30°C
3.33
2-oxoglutarate
isoform TAT1, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
3.5
2-oxoglutarate
mutant N54S, pH 7.5, 37°C
4.6
2-oxoglutarate
wild-type, pH 7.5, 37°C
7.62
2-oxoglutarate
isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
9.6
2-oxoglutarate
mutant N17S, pH 7.5, 37°C
10.8
2-oxoglutarate
-
with L-tyrosine as cosubstrate, at pH 8.0 and 30°C
14.8
2-oxoglutarate
mutant R20A, pH 7.5, 37°C
38
2-oxoglutarate
-
pH 7.0, 37°C, tyrosine as co-substrate
3300
2-oxoglutarate
-
wild type enzyme
0.3
2-oxoisocaproate
mutant R20A, pH 7.5, 37°C
2.8
2-oxoisocaproate
mutant N17S, pH 7.5, 37°C
20.4
2-oxoisocaproate
wild-type, pH 7.5, 37°C
0.41
4-hydroxyphenylpyruvate
isoform TAT2, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
0.48
4-hydroxyphenylpyruvate
-
with L-glutamate as cosubstrate, at pH 8.0 and 30°C
0.7
4-hydroxyphenylpyruvate
-
pH 7.0, 38°C
7.9
4-hydroxyphenylpyruvate
cosubstrate phenylalanine, pH 10.0, 30°C
10.1
4-hydroxyphenylpyruvate
isoform TAT1, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
0.74
4-methylthio-2-oxobutanoate
isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
0.807
4-methylthio-2-oxobutanoate
isoform TAT2, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
1.3
4-methylthio-2-oxobutanoate
isoform TAT1, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
3.46
4-methylthio-2-oxobutanoate
isoform TAT1, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
0.9
L-alanine
wild-type, pH 7.5, 37°C
1.2
L-alanine
mutant N17S, pH 7.5, 37°C
1.2
L-alanine
mutant R20A, pH 7.5, 37°C
1.4
L-glutamate
pH 8.2, 30°C
1.9
L-glutamate
mutant R315K, pH 7.5, 37°C
2.2
L-glutamate
wild-type, pH 7.5, 37°C
4.9
L-glutamate
-
pH 7.0, 38°C
8.8
L-glutamate
mutant N54S, pH 7.5, 37°C
11.1
L-glutamate
cosubstrate phenylpyruvate, pH 10.0, 30°C
1.7
L-methionine
isoform TAT2, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
24.2
L-methionine
isoform TAT1, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
0.84
L-phenylalanine
pH 8.2, 30°C
3.572
L-phenylalanine
with pyruvate as cosubstrate, at pH 8.0 and 37°C
4.3
L-phenylalanine
cosubstrate 4-hydroxyphenylpyruvate, pH 10.0, 30°C
6.33
L-phenylalanine
-
pH 8.5, 30°C
6.7
L-phenylalanine
isoform TAT2, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
6.94
L-phenylalanine
isoform TAT1, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
10.2
L-phenylalanine
-
with 2-oxoglutarate as cosubstrate, at pH 8.0 and 30°C
11.4
L-phenylalanine
-
pH 7.0, 38°C
13.8
L-phenylalanine
cosubstrate 2-oxoglutarate, pH 10.0, 30°C
17.9
L-phenylalanine
-
pH 7.0, 37°C, pyruvate as co-substrate
5.055
L-tryptophan
with pyruvate as cosubstrate, at pH 8.0 and 37°C
7.83
L-tryptophan
-
pH 8.5, 30°C
8.14
L-tryptophan
-
with 2-oxoglutarate as cosubstrate, at pH 8.0 and 30°C
0.19
L-tyrosine
pH 8.2, 30°C
0.204
L-tyrosine
isoform TAT1, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
0.21
L-tyrosine
-
aspartate aminotransferase with mutations HEX and I73V, A293D, pH 8.0, 25°C
0.29
L-tyrosine
-
aspartate aminotransferase with mutations HEX and I73V, pH 8.0, 25°C
0.33
L-tyrosine
-
aspartate aminotransferase with mutations HEX and A293D, pH 8.0, 25°C
0.4
L-tyrosine
-
with 2-oxoglutarate as cosubstrate, at pH 8.0 and 30°C
0.45
L-tyrosine
-
pH 9.2, 40°C, isoenzyme TAT-3
0.5
L-tyrosine
-
pH 7.6, 37°C
0.7809
L-tyrosine
with alpha-ketomethiobutyrate as cosubstrate, at pH 8.0 and 37°C
1.2
L-tyrosine
wild-type, pH 7.5, 37°C
1.4
L-tyrosine
-
pH 7.6, 37°C, enzyme form II
1.8
L-tyrosine
-
pH 7.0, 38°C
1.82
L-tyrosine
-
pH 8.5, 30°C
1.86
L-tyrosine
-
in liver
1.9
L-tyrosine
cosubstrate phenylpyruvate, pH 10.0, 30°C
2.1
L-tyrosine
-
pH 7.6, 37°C
2.1
L-tyrosine
wild-type, pH 7.5, 37°C
2.3
L-tyrosine
mutant R20A, pH 7.5, 37°C
2.3
L-tyrosine
mutant R315K, pH 7.5, 37°C
2.4
L-tyrosine
mutant N17S, pH 7.5, 37°C
2.5 - 5
L-tyrosine
-
in white muscle
2.9
L-tyrosine
isoform TAT2, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
3.4
L-tyrosine
-
pH 7.2, 37°C
3.468
L-tyrosine
N-terminal domain, with pyruvate as cosubstrate, at pH 8.0 and 37°C
3.5
L-tyrosine
with pyruvate as cosubstrate, at pH 8.0 and 37°C
4.581
L-tyrosine
C-terminal domain, with pyruvate as cosubstrate, at pH 8.0 and 37°C
5
L-tyrosine
-
pH 9.2, 40°C, isoenzyme TAT-2
5.3
L-tyrosine
mutant N54S, pH 7.5, 37°C
6.8
L-tyrosine
-
pH 7.0, 37°C, pyruvate as co-substrate
15
L-tyrosine
-
pH 7.9, 37°C
20
L-tyrosine
-
pH 9.2, 40°C, isoenzyme TAT-1
67
L-tyrosine
-
mutant enzyme I249A
870
L-tyrosine
-
wild type enzyme
1.82
oxaloacetate
-
with L-glutamate as cosubstrate, at pH 8.0 and 30°C
4.72
oxaloacetate
-
with L-tyrosine as cosubstrate, at pH 8.0 and 30°C
16
oxaloacetate
-
pH 7.0, 37°C, tyrosine as co-substrate
42.9
oxaloacetate
isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
56.13
oxaloacetate
-
pH 8.5, 30°C
1.2
p-hydroxyphenylpyruvate
wild-type, pH 7.5, 37°C
1.2
p-hydroxyphenylpyruvate
mutant R315K, pH 7.5, 37°C
1.3
p-hydroxyphenylpyruvate
mutant N54S, pH 7.5, 37°C
580
p-hydroxyphenylpyruvate
-
wild type enzyme
0.455
phenylpyruvate
isoform TAT1, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
0.84
phenylpyruvate
-
with L-glutamate as cosubstrate, at pH 8.0 and 30°C
0.9
phenylpyruvate
-
pH 7.0, 38°C
1.28
phenylpyruvate
isoform TAT2, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
1.5
phenylpyruvate
cosubstrate L-tyrosine, pH 10.0, 30°C
2.6
phenylpyruvate
cosubstrate L-glutamate, pH 10.0, 30°C
3.06
phenylpyruvate
isoform TAT1, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
3.43
phenylpyruvate
isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
3.9
phenylpyruvate
-
with L-tyrosine as cosubstrate, at pH 8.0 and 30°C
0.5
pyruvate
-
pH 7.0, 37°C, tyrosine as co-substrate
0.6
pyruvate
mutant N17S, pH 7.5, 37°C
0.6
pyruvate
mutant R20A, pH 7.5, 37°C
0.8
pyruvate
wild-type, pH 7.5, 37°C
2.45
pyruvate
-
pH 8.5, 30°C
42.67
pyruvate
with L-tyrosine as cosubstrate, at pH 8.0 and 37°C
52.06
pyruvate
-
with L-tyrosine as cosubstrate, at pH 8.0 and 30°C
21.4
tryptophan
-
pH 7.0, 37°C, pyruvate as co-substrate
30
tryptophan
-
pH 7.9, 37°C
60
tryptophan
-
pH 7.2, 37°C
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
-
-
additional information
additional information
-
non-Michaelis complex kinetic
-
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11.8
(S)-beta-phenylalanine
pH 7.6, 30°C
0.22 - 566
2-oxoglutarate
1.83
2-Oxohexanoate
-
pH 7.0, 38°C
0.4 - 34
2-oxoisocaproate
0.121 - 23.9
4-hydroxyphenylpyruvate
0.37 - 20.1
4-methylthio-2-oxobutanoate
0.08 - 31.6
L-phenylalanine
1.2 - 165
p-hydroxyphenylpyruvate
0.13 - 30.2
phenylpyruvate
0.22
2-oxoglutarate
-
pH 8.5, 30°C
0.25
2-oxoglutarate
-
wild type enzyme
0.3
2-oxoglutarate
-
mutant enzyme I249A
0.5
2-oxoglutarate
mutant R20A, pH 7.5, 37°C
0.53
2-oxoglutarate
isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
0.63
2-oxoglutarate
-
with L-tyrosine as cosubstrate, at pH 8.0 and 30°C
0.92
2-oxoglutarate
cosubstrate phenylalanine, pH 10.0, 30°C
4.2
2-oxoglutarate
mutant N17S, pH 7.5, 37°C
10.6
2-oxoglutarate
pH 7.6, 30°C
21.8
2-oxoglutarate
wild-type, pH 7.5, 37°C
25.66
2-oxoglutarate
-
pH 7.0, 38°C
48
2-oxoglutarate
isoform TAT1, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
116
2-oxoglutarate
mutant N54S, pH 7.5, 37°C
490
2-oxoglutarate
mutant R315K, pH 7.5, 37°C
566
2-oxoglutarate
wild-type, pH 7.5, 37°C
0.4
2-oxoisocaproate
mutant R20A, pH 7.5, 37°C
9.3
2-oxoisocaproate
mutant N17S, pH 7.5, 37°C
34
2-oxoisocaproate
wild-type, pH 7.5, 37°C
0.121
4-hydroxyphenylpyruvate
-
with L-glutamate as cosubstrate, at pH 8.0 and 30°C
0.43
4-hydroxyphenylpyruvate
isoform TAT2, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
0.7
4-hydroxyphenylpyruvate
cosubstrate phenylalanine, pH 10.0, 30°C
15.83
4-hydroxyphenylpyruvate
-
pH 7.0, 38°C
23.9
4-hydroxyphenylpyruvate
isoform TAT1, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
0.37
4-methylthio-2-oxobutanoate
isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
0.7
4-methylthio-2-oxobutanoate
isoform TAT2, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
18.5
4-methylthio-2-oxobutanoate
isoform TAT1, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
20.1
4-methylthio-2-oxobutanoate
isoform TAT1, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
0.35
L-alanine
mutant R20A, pH 7.5, 37°C
3.8
L-alanine
mutant N17S, pH 7.5, 37°C
23.5
L-alanine
wild-type, pH 7.5, 37°C
0.44
L-glutamate
cosubstrate phenylpyruvate, pH 10.0, 30°C
3.8
L-glutamate
-
wild type enzyme
6.6
L-glutamate
mutant N54S, pH 7.5, 37°C
9.33
L-glutamate
-
pH 7.0, 38°C
69
L-glutamate
-
wild type enzyme
199
L-glutamate
mutant R315K, pH 7.5, 37°C
210
L-glutamate
wild-type, pH 7.5, 37°C
0.53
L-methionine
isoform TAT2, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
26.6
L-methionine
isoform TAT1, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
0.08
L-phenylalanine
-
pH 8.5, 30°C
0.17
L-phenylalanine
cosubstrate 4-hydroxyphenylpyruvate, pH 10.0, 30°C
0.44
L-phenylalanine
cosubstrate 2-oxoglutarate, pH 10.0, 30°C
0.51
L-phenylalanine
isoform TAT2, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
1.55
L-phenylalanine
-
with 2-oxoglutarate as cosubstrate, at pH 8.0 and 30°C
15.33
L-phenylalanine
-
pH 7.0, 38°C
31.6
L-phenylalanine
isoform TAT1, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
0.36
L-tryptophan
-
pH 8.5, 30°C
1.05
L-tryptophan
-
with 2-oxoglutarate as cosubstrate, at pH 8.0 and 30°C
0.24
L-tyrosine
-
pH 8.5, 30°C
0.7
L-tyrosine
mutant R20A, pH 7.5, 37°C
0.75
L-tyrosine
isoform TAT2, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
1
L-tyrosine
-
wild type enzyme
1.19
L-tyrosine
-
with 2-oxoglutarate as cosubstrate, at pH 8.0 and 30°C
1.2
L-tyrosine
-
mutant enzyme I249A
1.48
L-tyrosine
cosubstrate phenylpyruvate, pH 10.0, 30°C
1.8
L-tyrosine
mutant N17S, pH 7.5, 37°C
19.33
L-tyrosine
-
pH 7.0, 38°C
24
L-tyrosine
-
aspartate aminotransferase with mutations HEX, pH 8.0, 25°C
25.6
L-tyrosine
-
aspartate aminotransferase with mutations HEX and I73V, pH 8.0, 25°C
35.7
L-tyrosine
-
aspartate aminotransferase with mutations HEX and I73V, A293D, pH 8.0, 25°C
39
L-tyrosine
-
aspartate aminotransferase with mutations HEX and A293D, pH 8.0, 25°C
44.6
L-tyrosine
wild-type, pH 7.5, 37°C
57.3
L-tyrosine
isoform TAT1, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C
83
L-tyrosine
-
wild type enzyme
132
L-tyrosine
mutant N54S, pH 7.5, 37°C
510
L-tyrosine
mutant R315K, pH 7.5, 37°C
576
L-tyrosine
wild-type, pH 7.5, 37°C
0.11
oxaloacetate
-
with L-glutamate as cosubstrate, at pH 8.0 and 30°C
0.37
oxaloacetate
-
pH 8.5, 30°C
0.56
oxaloacetate
isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
0.73
oxaloacetate
-
with L-tyrosine as cosubstrate, at pH 8.0 and 30°C
1.2
p-hydroxyphenylpyruvate
-
wild type enzyme
5.9
p-hydroxyphenylpyruvate
mutant N54S, pH 7.5, 37°C
155
p-hydroxyphenylpyruvate
mutant R315K, pH 7.5, 37°C
165
p-hydroxyphenylpyruvate
wild-type, pH 7.5, 37°C
0.13
phenylpyruvate
isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
0.15
phenylpyruvate
-
with L-glutamate as cosubstrate, at pH 8.0 and 30°C
0.3
phenylpyruvate
-
with L-tyrosine as cosubstrate, at pH 8.0 and 30°C
0.47
phenylpyruvate
isoform TAT2, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
1.19
phenylpyruvate
cosubstrate L-glutamate, pH 10.0, 30°C
1.46
phenylpyruvate
cosubstrate L-tyrosine, pH 10.0, 30°C
2.66
phenylpyruvate
-
pH 7.0, 38°C
24.5
phenylpyruvate
isoform TAT1, with L-glutamate as cosubstrate, at pH 8.5 and 30°C
30.2
phenylpyruvate
isoform TAT1, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
0.34
pyruvate
-
pH 8.5, 30°C
0.5
pyruvate
mutant R20A, pH 7.5, 37°C
0.89
pyruvate
-
with L-tyrosine as cosubstrate, at pH 8.0 and 30°C
1.5
pyruvate
mutant N17S, pH 7.5, 37°C
47.4
pyruvate
wild-type, pH 7.5, 37°C
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Gohda, E.; Pitot, H.C.
Purification and characterization of a factor catalyzing the conversion of the multiple forms of tyrosine aminotransferase from rat liver
J. Biol. Chem.
255
7371-7379
1980
Rattus norvegicus
brenda
Miller, J.E.; Litwack, G.
Purification, properties, and identity of liver mitochondrial tyrosine aminotransferase
J. Biol. Chem.
246
3234-3240
1971
Rattus norvegicus
brenda
Hargrove, J.L.; Granner, D.K.
Purification of the native form of tyrosine aminotransferase from rat liver
Anal. Biochem.
104
231-235
1980
Rattus norvegicus
brenda
Lee, K.L.; Roberson, L.E.; Kenney, F.T.
Properties of tyrosine aminotransferase from rat liver
Anal. Biochem.
95
188-193
1979
Rattus norvegicus
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Hargrove, J.L.; Granner, D.K.
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