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Reference on EC 2.6.1.42 - branched-chain-amino-acid transaminase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xing, R.; Whitman, W.B.
Characterization of enzymes of the branched-chain amino acid biosynthetic pathway in Methanococcus spp
J. Bacteriol.
173
2086-2092
1991
Methanococcus aeolicus, Methanococcus maripaludis, Methanococcus voltae
Manually annotated by BRENDA team
Xing, R.; Whitman, W.B.
Characterization of amino acid aminotransferases of Methanococcus aeolicus
J. Bacteriol.
174
541-548
1974
Methanococcus aeolicus
Manually annotated by BRENDA team
Rudman, D.; Meister, A.
Transamination in Escherichia coli
J. Biol. Chem.
200
591-604
1953
Escherichia coli
Manually annotated by BRENDA team
Ichihara, A.; Koyama, E.
Transaminase of branched chain amino acids. I. Branched chain amino acids-alpha-ketoglutarate transaminase
J. Biochem.
59
160-169
1966
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Taylor, R.T.; Jenkins, W.T.
Leucine aminotransferase. 3. Activation by beta-mercaptoethanol
J. Biol. Chem.
241
4406-4410
1966
Sus scrofa
Manually annotated by BRENDA team
Taylor, R.T.; Jenkins, W.T.
Leucine aminotransferase. II. Purification and characterization
J. Biol. Chem.
241
4396-4405
1966
Sus scrofa
Manually annotated by BRENDA team
Aki, K.; Ogawa, K.; Ichihara, A.
Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver
Biochim. Biophys. Acta
159
276-284
1968
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Aki, K.; Yokojima, A.; Ichihara, A.
Transaminase of branched chain amino acids. VI. Purification and properties of the hog brain enzyme
J. Biochem.
65
539-544
1969
Sus scrofa
Manually annotated by BRENDA team
Collins, M.; Wagner, R.P.
Branded chain amino acid aminotransferases of Neurospora crassa
Arch. Biochem. Biophys.
155
184-193
1973
Neurospora crassa
Manually annotated by BRENDA team
Tachiki, T.; Tochikura, T.
Separation of L-leucine-pyruvate and L-leucine-alpha-ketoglutarate transaminases in Acetobacter suboxydans and identification of their reaction products
Agric. Biol. Chem.
37
1439-1448
1973
Gluconobacter oxydans
-
Manually annotated by BRENDA team
Lipscomb, E.L.; Horton, H.R.; Armstrong, F.B.
Molecular weight, subunit structure, and amino acid composition of the branched chain amino acid aminotransferase of Salmonella typhimurium
Biochemistry
13
2071-2077
1974
Salmonella enterica subsp. enterica serovar Typhimurium
-
Manually annotated by BRENDA team
Wakita, M.; Hoshino, S.
A branched-chain amino acid aminotransferase from the rumen ciliate genus Entodinium
J. Protozool.
22
281-285
1975
Entodinium sp.
Manually annotated by BRENDA team
Monnier, N.; Montmitonnet, A.; Chesne, S.; Pelmont, J.
Transaminase B from Escherichia coli. I.-Purification and first properties
Biochimie
58
663-675
1976
Escherichia coli
Manually annotated by BRENDA team
Tachiki, T.; Tochikura, T.
Purification and characterization of L-leucine-alpha-ketoglutarate transaminase from Acetobacter suboxydans
Agric. Biol. Chem.
40
2187-2192
1976
Gluconobacter oxydans
-
Manually annotated by BRENDA team
Koide, Y.; Honma, M.; Shimomura, T.
Branched chain amino acid aminotransferase of Pseudomonas sp.
Agric. Biol. Chem.
41
1171-1177
1977
Pseudomonas sp.
-
Manually annotated by BRENDA team
Lee-Peng, F.C.; Hermodson, M.A.; Kohlhaw, G.B.
Transaminase B from Escherichia coli: quaternary structure, amino-terminal sequence, substrate specificity, and absence of a separate valine-alpha-ketoglutarate activity
J. Bacteriol.
139
339-345
1979
Escherichia coli
Manually annotated by BRENDA team
Aarnes, H.
Branched chain amino acid aminotransferase in barley seedlings
Z. Pflanzenphysiol.
102
81-89
1981
Hordeum vulgare
-
Manually annotated by BRENDA team
Shiio, I.; Mori, M.; Ozaki, H.
Amino acid aminotransferase in an amino acid-producing bacterium, Brevibacterium flavum
Agric. Biol. Chem.
46
2967-2977
1982
[Brevibacterium] flavum
-
Manually annotated by BRENDA team
Kawagishi, S.
Two isozymes of branched-chain amino acid aminotransferase in submandibular gland of the monkey
Shika Kiso Igakkai Zasshi
26
947-952
1984
Macaca sp.
-
Manually annotated by BRENDA team
Cooper, A.J.L.
Glutamate-branched-chain amino acid transaminase
Methods Enzymol.
113
71-73
1985
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Korpela, T.K.; Saarinen, R.
Affinity chromatography of B6-vitamin-dependent enzymes: purification of pig-heart branched-chain amino acid transaminase
J. Chromatogr.
318
333-341
1985
Sus scrofa
Manually annotated by BRENDA team
Bode, R.; Birnbaum, D.
Purification and properties of two branched-chain amino acid aminotransferases from the yeast Candida maltosa
Biochem. Physiol. Pflanz.
183
417-424
1988
Candida maltosa
-
Manually annotated by BRENDA team
Inoue, K.; Kuramitsu, S.; Aki, K.; Watanabe, Y.; Takagi, T.; Nishigai, M.; Ikai, A.; Kagamiyama, H.
Branched-chain amino acid aminotransferase of Escherichia coli: overproduction and properties
J. Biochem.
104
777-784
1988
Escherichia coli, Escherichia coli W3110 / ATCC 27325
Manually annotated by BRENDA team
Kido, R.
Pancreatic branched-chain-amino-acid aminotransferase
Methods Enzymol.
166
275-281
1988
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Korpela, T.K.
Purification of branched-chain-amino-acid aminotransferase from pig heart
Methods Enzymol.
166
269-274
1988
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Feild, M.J.; Nguyen, D.C.; Armstrong, F.B.
Amino acid sequence of Salmonella typhimurium branched-chain amino acid aminotransferase
Biochemistry
28
5306-5310
1989
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Kamitori, S.; Odagaki, Y.; Inoue, K.; Kuramitsu, S.; Kagamiyama, H.; Matsuura, Y.; Higuchi, T.
Crystallization and preliminary X-ray characterization of branched-chain amino acid aminotransferase from Escherichia coli
J. Biochem.
105
671-672
1989
Escherichia coli
Manually annotated by BRENDA team
Wallin, R.; Hall, T.R.; Hutson, S.M.
Purification of branched chain aminotransferase from rat heart mitochondria
J. Biol. Chem.
265
6019-6024
1990
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Hall, T.R.; Wallin, R.; Reinhart, G.D.; Hutson, S.M.
Branched chain aminotransferase isoenzymes. Purification and characterization of the rat brain isoenzyme
J. Biol. Chem.
268
3092-3098
1993
Rattus norvegicus
Manually annotated by BRENDA team
Kanda, M.; Hori, K.; Kurotsu, T.; Ohgishi, K.; Hanawa, T.; Saito, Y.
Purification and properties of branched chain amino acid aminotransferase from gramicidin S-producing Bacillus brevis
J. Nutr. Sci. Vitaminol.
41
51-60
1995
Brevibacillus brevis
Manually annotated by BRENDA team
Schadewaldt, P.; Wendel, U.; Hammen, H.W.
Human branched-chain L-amino acid aminotransferase: activity and subcellular localization in cultured skin fibroblasts
Amino Acids
9
147-160
1995
Homo sapiens
Manually annotated by BRENDA team
Kispal, G.; Steiner, H.; Court, D.A.; Rolinski, B.; Lill, R.
Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein
J. Biol. Chem.
271
24458-24464
1996
Saccharomyces cerevisiae (P38891), Saccharomyces cerevisiae (P47176), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Schadewaldt, P.; Adelmeyer, F.
Coupled enzymatic assay for estimation of branched-chain L-amino acid aminotransferase activity with 2-Oxo acid substrates
Anal. Biochem.
238
65-71
1996
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Eden, A.; Benvenisty, N.
Characterization of a branched-chain amino-acid aminotransferase from Schizosaccharomyces pombe
Yeast
14
189-194
1998
Schizosaccharomyces pombe (O14370), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Hutson, S.M.; Berkich, D.; Drown, P.; Xu, B.; Aschner, M.; LaNoue, K.F.
Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism
J. Neurochem.
71
863-874
1998
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Faure, M.; Glomot, F.; Bledsoe, R.; Hutson, S.; Papet, I.
Purification and cloning of the mitochondrial branched-chain amino acid aminotransferase from sheep placenta
Eur. J. Biochem.
259
104-111
1999
Ovis aries, Ovis aries (O97932)
Manually annotated by BRENDA team
Atiles, M.W.; Dudley, E.G.; Steele, J.L.
Gene cloning, sequencing, and inactivation of the branched-chain aminotransferase of Lactococcus lactis LM0230
Appl. Environ. Microbiol.
66
2325-2329
2000
Lactococcus lactis, Lactococcus lactis LM0230
Manually annotated by BRENDA team
Bonfils, J.; Faure, M.; Gibrat, J.F.; Glomot, F.; Papet, I.
Sheep cytosolic branched-chain amino acid aminotransferase: cDNA cloning, primary structure and molecular modelling and its unique expression in muscles
Biochim. Biophys. Acta
1494
129-136
2000
Ovis aries, Ovis aries (O97932), Ovis aries (Q9GKM4)
Manually annotated by BRENDA team
Conway, M.E.; Hutson, S.M.
Mammalian branched-chain aminotransferases
Methods Enzymol.
324
355-365
2000
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kagamiyama, H.; Hayashi, H.
Branched-chain amino-acid aminotransferase of Escherichia coli
Methods Enzymol.
324
103-113
2000
Escherichia coli, Escherichia coli W3110 / ATCC 27325
Manually annotated by BRENDA team
Schadewaldt, P.
Determination of branched-chain L-amino-acid aminotransferase activity
Methods Enzymol.
324
23-32
2000
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Yvon, M.; Chambellon, E.; Bolotin, A.; Roudot-Algaron, F.
Characterization and role of the branched-chain aminotransferase (BcaT) isolated from Lactococcus lactis subsp. cremoris NCDO 763
Appl. Environ. Microbiol.
66
571-577
2000
Lactococcus lactis, Lactococcus lactis (Q7BPX6)
Manually annotated by BRENDA team
Eden, A.; Van Nedervelde, L.; Drukker, M.; Benvenisty, N.; Debourg, A.
Involvement of branched-chain amino acid aminotransferases in the production of fusel alcohols during fermentation in yeast
Appl. Microbiol. Biotechnol.
55
296-300
2001
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P47176)
Manually annotated by BRENDA team
Faure, M.; Glomot, F.; Papet, I.
Branched-chain amino acid aminotransferase activity decreases during development in skeletal muscles of sheep
J. Nutr.
131
1528-1534
2001
Ovis aries
Manually annotated by BRENDA team
Lin, H.M.; Kaneshige, M.; Zhao, L.; Zhang, X.; Hanover, J.A.; Cheng, S.Y.
An isoform of branched-chain aminotransferase is a novel co-repressor for thyroid hormone nuclear receptors
J. Biol. Chem.
276
48196-48205
2001
Homo sapiens, Homo sapiens (O15382), Saccharomyces cerevisiae (P47176), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Okada, K.; Hirotsu, K.; Hayashi, H.; Kagamiyama, H.
Structures of Escherichia coli branched-chain amino acid aminotransferase and its complexes with 4-methylvalerate and 2-methylleucine: Induced fit and substrate recognition of the enzyme
Biochemistry
40
7453-7463
2001
Escherichia coli (P0AB80), Escherichia coli
Manually annotated by BRENDA team
Torres, N.; Vargas, C.; Hernandez-Pando, R.; Orozco, H.; Hutson, S.M.; Tovar, A.R.
Ontogeny and subcellular localization of rat liver mitochondrial branched chain amino-acid aminotransferase
Eur. J. Biochem.
268
6132-6139
2001
Rattus norvegicus
Manually annotated by BRENDA team
Yennawar, N.; Dunbar, J.; Conway, M.; Hutson, S.; Farber, G.
The structure of human mitochondrial branched-chain aminotransferase
Acta Crystallogr. Sect. D
57
506-515
2001
Homo sapiens
Manually annotated by BRENDA team
Cooper, A.J.; Conway, M.; Hutson, S.M.
A continuous 96-well plate spectrophotometric assay for branched-chain amino acid aminotransferases
Anal. Biochem.
308
100-105
2002
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Diebold, R.; Schuster, J.; Daeschner, K.; Binder, S.
The branched-chain amino acid transaminase gene family in Arabidopsis encodes plastid and mitochondrial proteins
Plant Physiol.
129
540-550
2002
Arabidopsis sp., Arabidopsis thaliana (Q93Y32), Arabidopsis thaliana (Q9FYA6), Arabidopsis thaliana (Q9LE06), Arabidopsis thaliana (Q9LPM9), Arabidopsis thaliana (Q9M401), Arabidopsis thaliana (Q9M439)
Manually annotated by BRENDA team
Madsen, S.M.; Beck, H.C.; Ravn, P.; Vrang, A.; Hansen, A.M.; Israelsen, H.
Cloning and inactivation of a branched-chain-amino-acid aminotransferase gene from Staphylococcus carnosus and characterization of the enzyme
Appl. Environ. Microbiol.
68
4007-4014
2002
Staphylococcus carnosus
Manually annotated by BRENDA team
Conway, M.E.; Yennawar, N.; Wallin, R.; Poole, L.B.; Hutson, S.M.
Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines
Biochim. Biophys. Acta
1647
61-65
2003
Homo sapiens
Manually annotated by BRENDA team
Cooper, A.J.; Bruschi, S.A.; Conway, M.; Hutson, S.M.
Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate beta-lyases, but turnover leads to inactivation
Biochem. Pharmacol.
65
181-192
2003
Homo sapiens
Manually annotated by BRENDA team
Goto, M.; Miyahara, I.; Hayashi, H.; Kagamiyama, H.; Hirotsu, K.
Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: True reaction intermediate and double substrate recognition of the enzyme
Biochemistry
42
3725-3733
2003
Rattus norvegicus, Escherichia coli (P0AB80), Escherichia coli
Manually annotated by BRENDA team
Sweatt, A.J.; Wood, M.; Suryawan, A.; Wallin, R.; Willingham, M.C.; Hutson, S.M.
Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves
Am. J. Physiol.
286
E64-76
2004
Rattus norvegicus
Manually annotated by BRENDA team
Bondar, D.C.; Beckerich, J.M.; Bonnarme, P.
Involvement of a branched-chain aminotransferase in production of volatile sulfur compounds in Yarrowia lipolytica
Appl. Environ. Microbiol.
71
4585-4591
2005
Yarrowia lipolytica
Manually annotated by BRENDA team
Venos, E.S.; Knodel, M.H.; Radford, C.L.; Berger, B.J.
Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis
BMC Microbiol.
4
39
2004
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Beck, H.C.
Branched-chain fatty acid biosynthesis in a branched-chain amino acid aminotransferase mutant of Staphylococcus carnosus
FEMS Microbiol. Lett.
243
37-44
2005
Staphylococcus carnosus
Manually annotated by BRENDA team
Thage, B.V.; Rattray, F.P.; Laustsen, M.W.; Ardo, Y.; Barkholt, V.; Houlberg, U.
Purification and characterization of a branched-chain amino acid aminotransferase from Lactobacillus paracasei subsp. paracasei CHCC 2115
J. Appl. Microbiol.
96
593-602
2004
Lacticaseibacillus paracasei
Manually annotated by BRENDA team
Goto, M.; Miyahara, I.; Hirotsu, K.; Conway, M.; Yennawar, N.; Islam, M.M.; Hutson, S.M.
Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
J. Biol. Chem.
280
37246-37256
2005
Homo sapiens (O15382), Homo sapiens
Manually annotated by BRENDA team
Sweatt, A.J.; Garcia-Espinosa, M.A.; Wallin, R.; Hutson, S.M.
Branched-chain amino acids and neurotransmitter metabolism: expression of cytosolic branched-chain aminotransferase (BCATc) in the cerebellum and hippocampus
J. Comp. Neurol.
477
360-370
2004
Rattus norvegicus
Manually annotated by BRENDA team
Perez-Villasenor, G.; Tovar, A.R.; Moranchel, A.H.; Hernandez-Pando, R.; Hutson, S.M.; Torres, N.
Mitochondrial branched chain aminotransferase gene expression in AS-30D hepatoma rat cells and during liver regeneration after partial hepatectomy in rat
Life Sci.
78
334-339
2005
Rattus norvegicus
Manually annotated by BRENDA team
Schuster, J.; Binder, S.
The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana
Plant Mol. Biol.
57
241-254
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Chen, C.D.; Huang, T.F.; Lin, C.H.; Guan, H.H.; Hsieh, Y.C.; Lin, Y.H.; Huang, Y.C.; Liu, M.Y.; Chang, W.C.; Chen, C.J.
Purification, crystallization and preliminary X-ray crystallographic analysis of branched-chain aminotransferase from Deinococcus radiodurans
Acta Crystallogr. Sect. F
63
492-494
2007
Deinococcus radiodurans
Manually annotated by BRENDA team
Saito, M.; Nishimura, K.; Wakabayashi, S.; Kurihara, T.; Nagata, Y.
Purification of branched-chain amino acid aminotransferase from Helicobacter pylori NCTC 11637
Amino Acids
33
445-449
2007
Helicobacter pylori, Helicobacter pylori (Q0E9S8), Helicobacter pylori NCTC 11637, Helicobacter pylori NCTC 11637 (Q0E9S8)
Manually annotated by BRENDA team
Hu, L.Y.; Boxer, P.A.; Kesten, S.R.; Lei, H.J.; Wustrow, D.J.; Moreland, D.W.; Zhang, L.; Ahn, K.; Ryder, T.R.; Liu, X.; Rubin, J.R.; Fahnoe, K.; Carroll, R.T.; Dutta, S.; Fahnoe, D.C.; Probert, A.W.; Roof, R.L.; Rafferty, M.F.; Kostlan, C.R.; Scholten, J.D.; Hood, M.; Ren, X.D.; Schielke, G.P.; Su, T.Z.; Taylor, C.P.; Mi, M.i.s.
The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases
Bioorg. Med. Chem. Lett.
16
2337-2340
2006
Homo sapiens (P54687), Homo sapiens
Manually annotated by BRENDA team
Magnus, J.B.; Hollwedel, D.; Oldiges, M.; Takors, R.
Monitoring and modeling of the reaction dynamics in the valine/leucine synthesis pathway in Corynebacterium glutamicum
Biotechnol. Prog.
22
1071-1083
2006
Corynebacterium glutamicum
Manually annotated by BRENDA team
Castellano, S.; Macchi, F.; Scali, M.; Huang, J.Z.; Bozzi, Y.
Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice
Brain Res.
1108
12-18
2006
Rattus norvegicus
Manually annotated by BRENDA team
Lilly, M.; Bauer, F.F.; Styger, G.; Lambrechts, M.G.; Pretorius, I.S.
The effect of increased branched-chain amino acid transaminase activity in yeast on the production of higher alcohols and on the flavour profiles of wine and distillates
FEMS Yeast Res.
6
726-743
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Manually annotated by BRENDA team
Castellano, S.; Casarosa, S.; Sweatt, A.J.; Hutson, S.M.; Bozzi, Y.
Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain
Gene Expr. Patterns
7
485-490
2007
Mus musculus
Manually annotated by BRENDA team
Yennawar, N.H.; Islam, M.M.; Conway, M.; Wallin, R.; Hutson, S.M.
Human mitochondrial branched chain aminotransferase isozyme: structural role of the CXXC center in catalysis
J. Biol. Chem.
281
39660-39671
2006
Homo sapiens (O15382), Homo sapiens
Manually annotated by BRENDA team
Garcia-Espinosa, M.A.; Wallin, R.; Hutson, S.M.; Sweatt, A.J.
Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids
J. Neurochem.
100
1458-1468
2007
Rattus norvegicus
Manually annotated by BRENDA team
Brosnan, J.T.; Brosnan, M.E.
Branched-chain amino acids: enzyme and substrate regulation
J. Nutr.
136
207S-211S
2006
Homo sapiens
Manually annotated by BRENDA team
Schuster, J.; Knill, T.; Reichelt, M.; Gershenzon, J.; Binder, S.
Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis
Plant Cell
18
2664-2679
2006
Arabidopsis thaliana
Manually annotated by BRENDA team
Knopf, R.R.; Trebitsh, T.
The female-specific Cs-ACS1G gene of cucumber. A case of gene duplication and recombination between the non-sex-specific 1-aminocyclopropane-1-carboxylate synthase gene and a branched-chain amino acid transaminase gene
Plant Cell Physiol.
47
1217-1228
2006
Cucumis sativus
Manually annotated by BRENDA team
Malatrasi, M.; Corradi, M.; Svensson, J.T.; Close, T.J.; Gulli, M.; Marmiroli, N.
A branched-chain amino acid aminotransferase gene isolated from Hordeum vulgare is differentially regulated by drought stress
Theor. Appl. Genet.
113
965-976
2006
Hordeum vulgare (Q70KX9), Hordeum vulgare
Manually annotated by BRENDA team
Tremblay, L.W.; Blanchard, J.S.
The 1.9 A structure of the branched-chain amino-acid transaminase (IlvE) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
65
1071-1077
2009
Mycobacterium tuberculosis (P9WQ75), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ75)
Manually annotated by BRENDA team
Conway, M.E.; Coles, S.J.; Islam, M.M.; Hutson, S.M.
Regulatory control of human cytosolic branched-chain aminotransferase by oxidation and S-glutathionylation and its interactions with redox sensitive neuronal proteins
Biochemistry
47
5465-5479
2008
Homo sapiens
Manually annotated by BRENDA team
Hutson, S.M.; Poole, L.B.; Coles, S.; Conway, M.E.
Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase
Methods Mol. Biol.
476
135-148
2009
Homo sapiens
Manually annotated by BRENDA team
Caballero, J.; Vergara-Jaque, A.; Fernandez, M.; Coll, D.
Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferase
Mol. Divers.
13
493-500
2009
Homo sapiens (P54687), Homo sapiens
Manually annotated by BRENDA team
Gao, F.; Wang, C.; Wei, C.; Li, Y.
A branched-chain aminotransferase may regulate hormone levels by affecting KNOX genes in plants
Planta
230
611-623
2009
Nicotiana benthamiana (B6RFK8), Nicotiana benthamiana
Manually annotated by BRENDA team
Coles, S.J.; Hancock, J.T.; Conway, M.E.
Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase
Acta Biochim. Biophys. Sin. (Shanghai)
44
172-176
2012
Homo sapiens
Manually annotated by BRENDA team
Castell, A.; Mille, C.; Unge, T.
Structural analysis of mycobacterial branched-chain aminotransferase: implications for inhibitor design
Acta Crystallogr. Sect. D
66
549-557
2010
Mycobacterium tuberculosis, Mycolicibacterium smegmatis (A0R066), Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Ruan, J.; Hu, J.; Yin, A.; Wu, W.; Cong, X.; Feng, X.; Li, S.
Structure of the branched-chain aminotransferase from Streptococcus mutans
Acta Crystallogr. Sect. D
68
996-1002
2012
Streptococcus mutans (Q8DTW7), Streptococcus mutans, Streptococcus mutans UA159 (Q8DTW7)
Manually annotated by BRENDA team
Seo, Y.; Kim, A.; Bea, H.; Lee, S.; Yun, H.
Asymmetric synthesis of L-6-hydroxynorleucine from 2-keto-6-hydroxyhexanoic acid using a branched-chain aminotransferase
Biocatal. Biotransform.
30
171-176
2012
Escherichia coli
-
Manually annotated by BRENDA team
Freiding, S.; Ehrmann, M.A.; Vogel, R.F.
Comparison of different IlvE aminotransferases in Lactobacillus sakei and investigation of their contribution to aroma formation from branched chain amino acids
Food Microbiol.
29
205-214
2012
Enterococcus faecalis, Lacticaseibacillus paracasei, Staphylococcus carnosus
Manually annotated by BRENDA team
Santiago, B.; MacGilvray, M.; Faustoferri, R.C.; Quivey, R.G.
The branched-chain amino acid aminotransferase encoded by ilvE is involved in acid tolerance in Streptococcus mutans
J. Bacteriol.
194
2010-2019
2012
Streptococcus mutans, Streptococcus mutans UA159
Manually annotated by BRENDA team
Chen, C.D.; Lin, C.H.; Chuankhayan, P.; Huang, Y.C.; Hsieh, Y.C.; Huang, T.F.; Guan, H.H.; Liu, M.Y.; Chang, W.C.; Chen, C.J.
Crystal structures of complexes of the branched-chain aminotransferase from Deinococcus radiodurans with alpha-ketoisocaproate and L-glutamate suggest the radiation resistance of this enzyme for catalysis
J. Bacteriol.
194
6206-6216
2012
Deinococcus radiodurans (Q9RTX5), Deinococcus radiodurans
Manually annotated by BRENDA team
Seo, Y.M.; Yun, H.
Enzymatic synthesis of L-tert-leucine with branched chain aminotransferase
J. Microbiol. Biotechnol.
21
1049-1052
2011
Escherichia coli
Manually annotated by BRENDA team
Hong, E.; Cha, M.; Yun, H.; Kim, B.
Asymmetric synthesis of L-tert-leucine and L-3-hydroxyadamantylglycine using branched chain aminotransferase
J. Mol. Catal. B
66
228-233
2010
Escherichia coli, Enterobacter sp., Enterobacter sp. TL3
-
Manually annotated by BRENDA team
Hull, J.; Hindy, M.E.; Kehoe, P.G.; Chalmers, K.; Love, S.; Conway, M.E.
Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation
J. Neurochem.
123
997-1009
2012
Homo sapiens (O15382), Homo sapiens (P54687), Homo sapiens
Manually annotated by BRENDA team
Kochevenko, A.; Klee, H.J.; Fernie, A.R.; Araujo, W.L.
Molecular identification of a further branched-chain aminotransferase 7 (BCAT7) in tomato plants
J. Plant Physiol.
169
437-443
2012
Solanum lycopersicum, Solanum pennellii
Manually annotated by BRENDA team
Maloney, G.S.; Kochevenko, A.; Tieman, D.M.; Tohge, T.; Krieger, U.; Zamir, D.; Taylor, M.G.; Fernie, A.R.; Klee, H.J.
Characterization of the branched-chain amino acid aminotransferase enzyme family in tomato
Plant Physiol.
153
925-936
2010
Solanum lycopersicum, Solanum pennellii
Manually annotated by BRENDA team
Boyko, K.M.; Stekhanova, T.N.; Nikolaeva, A.Y.; Mardanov, A.V.; Rakitin, A.L.; Ravin, N.V.; Bezsudnova, E.Y.; Popov, V.O.
First structure of archaeal branched-chain amino acid aminotransferase from Thermoproteus uzoniensis specific for L-amino acids and R-amines
Extremophiles
20
215-225
2016
Thermoproteus uzoniensis (F2L0W0), Thermoproteus uzoniensis, Thermoproteus uzoniensis 768-20 (F2L0W0)
Manually annotated by BRENDA team
Pereboom, T.; Bondt, A.; Pallaki, P.; Klasson, T.; Goos, Y.; Essers, P.; Groot Koerkamp, M.; Gazda, H.; Holstege, F.; Costa, L.; MacInnes, A.
Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes
Exp. Hematol.
42
394-403
2014
Homo sapiens
Manually annotated by BRENDA team
Uchida, Y.; Hayashi, H.; Washio, T.; Yamasaki, R.; Kato, S.; Oikawa, T.
Cloning and characterization of a novel fold-type I branched-chain amino acid aminotransferase from the hyperthermophilic archaeon Thermococcus sp. CKU-1
Extremophiles
18
589-602
2014
Thermococcus sp. (A0A060PQX5)
Manually annotated by BRENDA team
Yu, X.; Wang, X.; Engel, P.C.
The specificity and kinetic mechanism of branched-chain amino acid aminotransferase from Escherichiacoli studied with a new improved coupled assay procedure and the enzymes potential for biocatalysis
FEBS J.
281
391-400
2014
Escherichia coli (P0AB80), Escherichia coli
Manually annotated by BRENDA team
Roncador, A.; Oppici, E.; Montioli, R.; Maset, F.; Cellini, B.
TAT-Mediated delivery of human alanine:glyoxylate aminotransferase in a cellular model of primary hyperoxaluria type I
Int. J. Pept. Res. Ther.
19
175-184
2013
Homo sapiens
-
Manually annotated by BRENDA team
Graindorge, M.; Giustini, C.; Kraut, A.; Moyet, L.; Curien, G.; Matringe, M.
Three different classes of aminotransferases evolved prephenate aminotransferase functionality in arogenate-competent microorganisms
J. Biol. Chem.
289
3198-3208
2014
Synechocystis sp. (P54691)
Manually annotated by BRENDA team
Wang, X.L.; Li, C.J.; Xing, Y.; Yang, Y.H.; Jia, J.P.
Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene
J. Inherit. Metab. Dis.
38
855-861
2015
Homo sapiens
Manually annotated by BRENDA team
Bertrand, S.M.; Ancellin, N.; Beaufils, B.; Bingham, R.P.; Borthwick, J.A.; Boullay, A.B.; Boursier, E.; Carter, P.S.; Chung, C.W.; Churcher, I.; Dodic, N.; Fouchet, M.H.; Fournier, C.; Francis, P.L.; Gummer, L.A.; Herry, K.; Hobbs, A.; Hobbs, C.I.; Homes, P.; Jamieson, C.; Nicodeme, E.; Pickett, S.D.; Reid, I.
The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits
J. Med. Chem.
58
7140-7163
2015
Mus musculus (O35855)
Manually annotated by BRENDA team
Laechler, K.; Imhof, J.; Reichelt, M.; Gershenzon, J.; Binder, S.
The cytosolic branched-chain aminotransferases of Arabidopsis thaliana influence methionine supply, salvage and glucosinolate metabolism
Plant Mol. Biol.
88
119-131
2015
Arabidopsis thaliana (Q9LPM9), Arabidopsis thaliana
Manually annotated by BRENDA team
Kingsbury, J.M.; Sen, N.D.; Cardenas, M.E.
Branched-chain aminotransferases control TORC1 signaling in Saccharomyces cerevisiae
PLoS Genet.
11
e1005714
2015
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Amorim Franco, T.M.; Favrot, L.; Vergnolle, O.; Blanchard, J.S.
Mechanism-based inhibition of the Mycobacterium tuberculosis branched-chain aminotransferase by D- and L-cycloserine
ACS Chem. Biol.
12
1235-1244
2017
Mycobacterium tuberculosis (P9WQ75), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ75)
Manually annotated by BRENDA team
Herbert, D.; Gibbs, S.; Riddick, A.; Conway, M.; Dong, M.
Crystal structure of an oxidized mutant of human mitochondrial branched-chain aminotransferase
Acta Crystallogr. Sect. F
76
14-19
2020
Homo sapiens (O15382), Homo sapiens
Manually annotated by BRENDA team
Conway, M.E.
Emerging moonlighting functions of the branched-chain aminotransferase proteins
Antioxid. Redox Signal.
34
1048-1067
2020
Homo sapiens (O15382), Homo sapiens (P54687)
Manually annotated by BRENDA team
Zheng, X.; Cui, Y.; Li, T.; Li, R.; Guo, L.; Li, D.; Wu, B.
Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids
Appl. Microbiol. Biotechnol.
103
8051-8062
2019
Pseudomonas sp.
Manually annotated by BRENDA team
Koonthongkaew, J.; Toyokawa, Y.; Ohashi, M.; Large, C.R.L.; Dunham, M.J.; Takagi, H.
Effect of the Ala234Asp replacement in mitochondrial branched-chain amino acid aminotransferase on the production of BCAAs and fusel alcohols in yeast
Appl. Microbiol. Biotechnol.
104
7915-7925
2020
Saccharomyces cerevisiae (P38891), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P38891)
Manually annotated by BRENDA team
Bezsudnova, E.Y.; Stekhanova, T.N.; Suplatov, D.A.; Mardanov, A.V.; Ravin, N.V.; Popov, V.O.
Experimental and computational studies on the unusual substrate specificity of branched-chain amino acid aminotransferase from Thermoproteus uzoniensis
Arch. Biochem. Biophys.
607
27-36
2016
Thermoproteus uzoniensis (F2L0W0), Thermoproteus uzoniensis, Thermoproteus uzoniensis 768-20 (F2L0W0)
Manually annotated by BRENDA team
Zhang, L.; Han, J.
Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function
Biochem. Biophys. Res. Commun.
486
224-231
2017
Homo sapiens (P54687), Homo sapiens
Manually annotated by BRENDA team
Bezsudnova, E.Y.; Boyko, K.M.; Popov, V.O.
Properties of bacterial and archaeal branched-chain amino acid aminotransferases
Biochemistry (Moscow)
82
1572-1591
2017
Lactococcus lactis, Pseudomonas sp., Thermococcus sp. CKU-1, Brevibacillus brevis (A0A2Z4MEX9), Lacticaseibacillus paracasei (A0A5Q8BPF5), Methanococcus aeolicus (A6UWA0), Vulcanisaeta moutnovskia (F0QW25), Thermoproteus uzoniensis (F2L0W0), Helicobacter pylori (O26004), Pseudomonas aeruginosa (O86428), Escherichia coli (P0AB80), Mycobacterium tuberculosis (P9WQ75), Gluconobacter oxydans (Q5FTR3), Pseudomonas aeruginosa ATCC 15692 (O86428), Gluconobacter oxydans 621H (Q5FTR3), Pseudomonas aeruginosa 1C (O86428), Pseudomonas aeruginosa PRS 101 (O86428), Methanococcus aeolicus DSM 17508 (A6UWA0), Helicobacter pylori ATCC 700392 (O26004), Pseudomonas aeruginosa DSM 22644 (O86428), Pseudomonas aeruginosa CIP 104116 (O86428), Pseudomonas aeruginosa LMG 12228 (O86428), Mycobacterium tuberculosis H37Rv (P9WQ75), Mycobacterium tuberculosis ATCC 25618 (P9WQ75), Helicobacter pylori 26695 (O26004), Vulcanisaeta moutnovskia 768-28 (F0QW25), Thermoproteus uzoniensis 768-20 (F2L0W0), Pseudomonas aeruginosa JCM 14847 (O86428), Methanococcus aeolicus OCM 812 (A6UWA0), Methanococcus aeolicus ATCC BAA-1280 (A6UWA0), Methanococcus aeolicus Nankai-3 (A6UWA0)
Manually annotated by BRENDA team
Amorim Franco, T.M.; Hegde, S.; Blanchard, J.S.
Chemical mechanism of the branched-chain aminotransferase IlvE from Mycobacterium tuberculosis
Biochemistry
55
6295-6303
2016
Mycobacterium tuberculosis (P9WQ75), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ75), Mycobacterium tuberculosis ATCC 25618 (P9WQ75)
Manually annotated by BRENDA team
Zeifman, Y.S.; Boyko, K.M.; Nikolaeva, A.Y.; Timofeev, V.I.; Rakitina, T.V.; Popov, V.O.; Bezsudnova, E.Y.
Functional characterization of PLP fold type IV transaminase with a mixed type of activity from Haliangium ochraceum
Biochim. Biophys. Acta
1867
575-585
2019
Haliangium ochraceum (D0LR31), Haliangium ochraceum, Haliangium ochraceum JCM 11303 (D0LR31), Haliangium ochraceum DSM 14365 (D0LR31), Haliangium ochraceum SMP-2 (D0LR31)
Manually annotated by BRENDA team
Kim, E.M.; Park, J.H.; Kim, B.G.; Seo, J.H.
Identification of (R)-selective omega-aminotransferases by exploring evolutionary sequence space
Enzyme Microb. Technol.
110
46-52
2018
Bacillus thuringiensis (A0A1B1L2T7), Bacillus thuringiensis, Evansella cellulosilytica (E6TUA8), Evansella cellulosilytica, Evansella cellulosilytica FERM P-1141 (E6TUA8), Evansella cellulosilytica ATCC 21833 (E6TUA8), Evansella cellulosilytica DSM 2522 (E6TUA8), Evansella cellulosilytica JCM 9156 (E6TUA8), Evansella cellulosilytica N-4 (E6TUA8)
Manually annotated by BRENDA team
Stekhanova, T.N.; Rakitin, A.L.; Mardanov, A.V.; Bezsudnova, E.Y.; Popov, V.O.
A novel highly thermostable branched-chain amino acid aminotransferase from the crenarchaeon Vulcanisaeta moutnovskia
Enzyme Microb. Technol.
96
127-134
2017
Vulcanisaeta moutnovskia (F0QW25), Vulcanisaeta moutnovskia, Vulcanisaeta moutnovskia 768-28 (F0QW25)
Manually annotated by BRENDA team
Anderson, L.C.; Hakansson, M.; Walse, B.; Nilsson, C.L.
Intact protein analysis at 21 tesla and X-ray crystallography define structural differences in single amino acid variants of human mitochondrial branched-chain amino acid aminotransferase 2 (BCAT2)
J. Am. Soc. Mass Spectrom.
28
1796-1804
2017
Homo sapiens (O15382), Homo sapiens
Manually annotated by BRENDA team
Weinhandl, K.; Ballach, M.; Winkler, M.; Ahmad, M.; Glieder, A.; Birner-Gruenberger, R.; Fotheringham, I.; Escalettes, F.; Camattari, A.
Pichia pastoris mutants as host strains for efficient secretion of recombinant branched chain aminotransferase (BCAT)
J. Biotechnol.
235
84-91
2016
Escherichia coli (P0AB80)
Manually annotated by BRENDA team
Bezsudnova, E.Y.; Dibrova, D.V.; Nikolaeva, A.Y.; Rakitina, T.V.; Popov, V.O.
Identification of branched-chain amino acid aminotransferases active towards (R)-(+)-1-phenylethylamine among PLP fold type IV transaminases
J. Biotechnol.
271
26-28
2018
Methanococcus vannielii (A6UP94), Thermomicrobium roseum (B9L0B7), Thermobaculum terrenum (D1CCW1), Methanococcus vannielii OCM 148 (A6UP94), Thermomicrobium roseum P-2 (B9L0B7), Methanococcus vannielii JCM 13029 (A6UP94), Methanococcus vannielii SB (A6UP94), Thermomicrobium roseum ATCC 27502 (B9L0B7), Methanococcus vannielii ATCC 35089 (A6UP94), Methanococcus vannielii DSM 1224 (A6UP94), Thermomicrobium roseum DSM 5159 (B9L0B7), Thermobaculum terrenum YNP1 (D1CCW1)
Manually annotated by BRENDA team
Borthwick, J.A.; Ancellin, N.; Bertrand, S.M.; Bingham, R.P.; Carter, P.S.; Chung, C.W.; Churcher, I.; Dodic, N.; Fournier, C.; Francis, P.L.; Hobbs, A.; Jamieson, C.; Pickett, S.D.; Smith, S.E.; Somers, D.O.; Spitzfaden, C.; Suckling, C.J.; Young, R.J.
Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening
J. Med. Chem.
59
2452-2467
2016
Homo sapiens (O15382)
Manually annotated by BRENDA team
Antunes, D.; Chowdhury, A.; Aich, A.; Saladi, S.; Harpaz, N.; Stahl, M.; Schuldiner, M.; Herrmann, J.M.; Rehling, P.; Rapaport, D.
Overexpression of branched-chain amino acid aminotransferases rescues the growth defects of cells lacking the Barth syndrome-related gene TAZ1
J. Mol. Med.
97
269-279
2019
Saccharomyces cerevisiae (P38891), Saccharomyces cerevisiae (P47176), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P38891), Saccharomyces cerevisiae ATCC 204508 (P47176)
Manually annotated by BRENDA team
Hammer, S.K.; Avalos, J.L.
Uncovering the role of branched-chain amino acid transaminases in Saccharomyces cerevisiae isobutanol biosynthesis
Metab. Eng.
44
302-312
2017
Saccharomyces cerevisiae (P38891), Saccharomyces cerevisiae (P47176), Saccharomyces cerevisiae ATCC 204508 (P38891), Saccharomyces cerevisiae ATCC 204508 (P47176)
Manually annotated by BRENDA team
Takpho, N.; Watanabe, D.; Takagi, H.
Valine biosynthesis in Saccharomyces cerevisiae is regulated by the mitochondrial branched-chain amino acid aminotransferase Bat1
Microb. Cell
5
293-299
2018
Saccharomyces cerevisiae (P38891), Saccharomyces cerevisiae (P47176), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lee, J.; Kim, Y.; Jung, Y.; Han, J.; Zhang, C.; Yun, C.; Lee, S.
The overexpression of cucumber (Cucumis sativus L.) genes that encode the branched-chain amino acid transferase modulate flowering time in Arabidopsis thaliana
Plant Cell Rep.
38
25-35
2019
Cucumis sativus var. sativus (A0A0A0KG15), Cucumis sativus var. sativus (A0A0A0LJI6), Cucumis sativus var. sativus (A0A0A0LN48)
Manually annotated by BRENDA team