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2-oxosuccinamic acid + aspartate
L-asparagine + 2-oxo-propane-1,3-dioate
-
-
-
-
?
2-oxosuccinamic acid + L-2-aminobutanoic acid
L-asparagine + 2-oxobutanoate
2-oxosuccinamic acid + L-alanine
L-asparagine + pyruvate
2-oxosuccinamic acid + L-cysteine
L-asparagine + 3-mercapto-2-oxopropanoate
-
-
-
-
?
2-oxosuccinamic acid + L-ethionine
L-asparagine + 4-ethylsulfanyl-2-oxobutanoate
-
-
-
-
?
2-oxosuccinamic acid + L-glutamine
L-asparagine + L-glutamate
2-oxosuccinamic acid + L-histidine
L-asparagine + 3-(1H-imidazol-4-yl)-2-oxopropanoate
-
-
-
-
?
2-oxosuccinamic acid + L-homocysteine
L-asparagine + 4-mercapto-2-oxobutanoate
-
-
-
-
?
2-oxosuccinamic acid + L-homoserine
L-asparagine + 4-hydroxy-2-oxobutanoate
-
-
-
-
?
2-oxosuccinamic acid + L-leucine
L-asparagine + 4-methyl-2-oxopentanoate
2-oxosuccinamic acid + L-methionine
L-asparagine + 4-methylsulfanyl-2-oxobutanoate
2-oxosuccinamic acid + L-methylcysteine
L-asparagine + ?
-
-
-
-
?
2-oxosuccinamic acid + L-norleucine
L-asparagine + 2-oxohexanoate
-
-
-
-
?
2-oxosuccinamic acid + L-norvaline
L-asparagine + 2-oxopentanoate
2-oxosuccinamic acid + L-phenylalanine
L-asparagine + 2-oxo-3-phenylpropanoate
-
-
-
-
?
2-oxosuccinamic acid + L-serine
L-asparagine + 3-hydroxy-2-oxopropanoate
-
-
-
-
?
2-oxosuccinamic acid + L-tryptophan
L-asparagine + 3-indole-2-oxopropanoate
-
-
-
-
?
2-oxosuccinamic acid + L-tyrosine
L-asparagine + 3-(4-hydroxyphenyl)-2-oxopropanoate
-
-
-
-
?
glyoxylate + amino acid
?
-
-
-
-
?
glyoxylate + L-asparagine
? + 2-oxosuccinamate
-
-
-
-
?
L-asparagine + 2-oxobutanoate
2-oxosuccinamate + 2-aminobutanoate
-
weak
-
-
r
L-asparagine + 2-oxoisohexanoate
2-oxosuccinamate + 2-aminoisohexanoate
-
-
-
-
?
L-asparagine + 2-oxosuccinamate
2-oxosuccinamate + L-asparagine
-
-
-
-
?
L-asparagine + 3-hydroxypyruvate
2-oxosuccinamate + L-serine
-
-
-
?
L-asparagine + 4-hydroxy-2-oxoglutarate
2-oxosuccinamate + 2-amino-4-hydroxyglutarate
-
-
-
-
?
L-asparagine + 4-methylsulfanyl-2-oxobutanoate
2-oxosuccinamate + L-methionine
L-asparagine + glyoxylate
2-oxosuccinamate + glycine
L-asparagine + L-glutamate
2-oxosuccinamate + L-glutamine
L-asparagine + pyruvate
2-oxosuccinamate + L-alanine
L-phenylalanine + pyruvate
phenylpyruvate + L-alanine
-
-
-
-
?
phenylpyruvate + L-asparagine
L-phenylalanine + 2-oxosuccinamate
phenylpyruvate + L-glutamine
L-phenylalanine + 2-oxoglutaramate
-
-
-
-
?
phenylpyruvate + L-homoserine
phenylalanine + 4-hydroxy-2-oxobutanoate
-
-
-
-
?
phenylpyruvate + methionine
L-phenylalanine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
-
?
additional information
?
-
2-oxosuccinamic acid + L-2-aminobutanoic acid
L-asparagine + 2-oxobutanoate
-
-
-
-
?
2-oxosuccinamic acid + L-2-aminobutanoic acid
L-asparagine + 2-oxobutanoate
-
-
-
-
?
2-oxosuccinamic acid + L-2-aminobutanoic acid
L-asparagine + 2-oxobutanoate
-
-
-
-
r
2-oxosuccinamic acid + L-alanine
L-asparagine + pyruvate
-
-
-
-
?
2-oxosuccinamic acid + L-alanine
L-asparagine + pyruvate
-
-
-
-
?
2-oxosuccinamic acid + L-glutamine
L-asparagine + L-glutamate
-
-
-
-
?
2-oxosuccinamic acid + L-glutamine
L-asparagine + L-glutamate
-
-
-
-
?
2-oxosuccinamic acid + L-leucine
L-asparagine + 4-methyl-2-oxopentanoate
-
-
-
-
?
2-oxosuccinamic acid + L-leucine
L-asparagine + 4-methyl-2-oxopentanoate
-
-
-
-
?
2-oxosuccinamic acid + L-methionine
L-asparagine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
-
r
2-oxosuccinamic acid + L-methionine
L-asparagine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
-
?
2-oxosuccinamic acid + L-methionine
L-asparagine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
-
r
2-oxosuccinamic acid + L-norvaline
L-asparagine + 2-oxopentanoate
-
-
-
-
?
2-oxosuccinamic acid + L-norvaline
L-asparagine + 2-oxopentanoate
-
-
-
-
?
L-asparagine + 4-methylsulfanyl-2-oxobutanoate
2-oxosuccinamate + L-methionine
-
weak
-
-
r
L-asparagine + 4-methylsulfanyl-2-oxobutanoate
2-oxosuccinamate + L-methionine
-
-
-
-
r
L-asparagine + glyoxylate
2-oxosuccinamate + glycine
-
-
-
?
L-asparagine + glyoxylate
2-oxosuccinamate + glycine
-
-
-
-
?
L-asparagine + glyoxylate
2-oxosuccinamate + glycine
-
-
-
-
?
L-asparagine + L-glutamate
2-oxosuccinamate + L-glutamine
-
-
-
?
L-asparagine + L-glutamate
2-oxosuccinamate + L-glutamine
-
-
-
?
L-asparagine + L-glutamate
2-oxosuccinamate + L-glutamine
-
-
-
?
L-asparagine + pyruvate
2-oxosuccinamate + L-alanine
-
-
-
?
L-asparagine + pyruvate
2-oxosuccinamate + L-alanine
-
-
-
-
?
L-asparagine + pyruvate
2-oxosuccinamate + L-alanine
-
-
-
-
?
phenylpyruvate + L-asparagine
L-phenylalanine + 2-oxosuccinamate
-
-
-
-
?
phenylpyruvate + L-asparagine
L-phenylalanine + 2-oxosuccinamate
-
-
-
-
?
additional information
?
-
-
the following 2-oxo acids are inactive at concentrations of 20 mM: 2-oxoglutarate, oxaloacetate, 2-oxoisopentanoate, L-2-oxo-3-methylvalerate, 3-sulfopyruvate, 3-hydroxy-2-oxobutanoate, trimethylpyruvate
-
-
?
additional information
?
-
-
no or very low activity with: L-valine, L-isoleucine, L-alloisoleucine, L-tertiary-leucine, L-2-aminophenylacetic acid, L-glutamic acid, L-aspartic acid
-
-
?
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physiological function
Arabidopsis thaliana asparagine aminotransferase (AGT1) is a multifunctional class IV aminotransferase protein that catalyzes transamination reactions using L-serine, L-alanine, and L-asparagine as amino donors and glyoxylate, pyruvate, and hydroxypyruvate as amino acceptors. AGT1 is a peroxisomal aminotransferase with a central role in photorespiration. This enzyme catalyzes various aminotransferase reactions, including serine:glyoxylate, alanine:glyoxylate, and asparagine:glyoxylate transaminations
additional information
development and evaluation of a method for the prediction of possible genes of orphan enzyme reactions where any associated gene sequences are not determined to date. The candidate enzyme gene of a reaction is detected using the chemical structures of the substrate-product pair (reactant pair). The proposed method is based on a search for similar reactant pairs in a reference database (KEGG database) and offers orthologeous groups that possibly mediate the given reaction. One example is the asparagine oxo-acid transaminase (R01346, EC 2.6.1.14), which transfers an amino group from asparagine to glutamate, the paralogue reactant pair is the asparagine-oxaloacetamide pair correlated to gene SMU_24 (UniProt ID Q8DWM1)
additional information
in the enzyme crystal, another dimer related by noncrystallographic symmetry makes close interactions to form a tetramer mediated in part by an extra carboxyl-terminal helix conserved in plant homologues of AGT1. Residues Tyr35' and Arg36', entering the active site from the other subunits in the dimer, mediate interactions between AGT and L-serine when used as a substrate. Structural model of AGT1 and structure-function analysis, structure comparisons, detailed overview
additional information
-
development and evaluation of a method for the prediction of possible genes of orphan enzyme reactions where any associated gene sequences are not determined to date. The candidate enzyme gene of a reaction is detected using the chemical structures of the substrate-product pair (reactant pair). The proposed method is based on a search for similar reactant pairs in a reference database (KEGG database) and offers orthologeous groups that possibly mediate the given reaction. One example is the asparagine oxo-acid transaminase (R01346, EC 2.6.1.14), which transfers an amino group from asparagine to glutamate, the paralogue reactant pair is the asparagine-oxaloacetamide pair correlated to gene SMU_24 (UniProt ID Q8DWM1)
-
additional information
-
development and evaluation of a method for the prediction of possible genes of orphan enzyme reactions where any associated gene sequences are not determined to date. The candidate enzyme gene of a reaction is detected using the chemical structures of the substrate-product pair (reactant pair). The proposed method is based on a search for similar reactant pairs in a reference database (KEGG database) and offers orthologeous groups that possibly mediate the given reaction. One example is the asparagine oxo-acid transaminase (R01346, EC 2.6.1.14), which transfers an amino group from asparagine to glutamate, the paralogue reactant pair is the asparagine-oxaloacetamide pair correlated to gene SMU_24 (UniProt ID Q8DWM1)
-
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Meister, A.; Fraser, P.E.
Enzymatic formation of L-asparagine by transamination
J. Biol. Chem.
210
37-43
1954
Rattus norvegicus
brenda
Cooper, A.J.L.
Asparagine transaminase from rat liver
J. Biol. Chem.
252
2032-2038
1977
Rattus norvegicus
brenda
Maul, D.M.; Schuster, S.M.
Kinetic properties and characteristics of mouse liver mitochondrial asparagine aminotransferase
Arch. Biochem. Biophys.
251
585-593
1986
Mus musculus
brenda
hongo, S.; Ito, H.; Takeda, M.; Sato, T.
Identity of rat liver mitochondrial asparagine-pyruvate transaminase with phenylalanine-pyruvate transaminase
Enzyme
36
232-238
1987
Rattus norvegicus
brenda
Liepman, A.H.; Vijayalakshmi, J.; Peisach, D.; Hulsebus, B.; Olsen, L.J.; Saper, M.A.
Crystal structure Of photorespiratory alanine glyoxylate aminotransferase 1 (AGT1) from Arabidopsis thaliana
Front. Plant Sci.
10
1229
2019
Arabidopsis thaliana (Q56YA5)
brenda
Moriya, Y.; Yamada, T.; Okuda, S.; Nakagawa, Z.; Kotera, M.; Tokimatsu, T.; Kanehisa, M.; Goto, S.
Identification of enzyme genes using chemical structure alignments of substrate-product pairs
J. Chem. Inf. Model.
56
510-516
2016
Streptococcus mutans serotype c (Q8DTM1), Streptococcus mutans serotype c ATCC 700610 (Q8DTM1), Streptococcus mutans serotype c UA159 (Q8DTM1)
brenda