Information on EC 2.6.1.108 - (5-formylfuran-3-yl)methyl phosphate transaminase

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The expected taxonomic range for this enzyme is: Methanocaldococcus jannaschii

EC NUMBER
COMMENTARY hide
2.6.1.108
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RECOMMENDED NAME
GeneOntology No.
(5-formylfuran-3-yl)methyl phosphate transaminase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-alanine + (5-formylfuran-3-yl)methyl phosphate = pyruvate + [5-(aminomethyl)furan-3-yl]methyl phosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
methanofuran biosynthesis
Methane metabolism
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SYSTEMATIC NAME
IUBMB Comments
L-alanine:(5-formylfuran-3-yl)methyl phosphate aminotransferase
A pyridoxal 5'-phosphate protein. The enzyme, characterized from the archaebacterium Methanocaldococcus jannaschii, participates in the biosynthesis of the cofactor methanofuran. Requires pyridoxal 5'-phosphate.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
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all methanofuran structural variants contain a basic core structure of 4-[N-(gamma-L-glutamyl)-p-(bet-aminoethyl)phenoxymethyl]-(aminomethyl)furan (APMF-Glu) but have different side chains depending on the source organism
metabolism
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the four genes mfnA, mfnB, mfnC, and mfnD are responsible for the biosynthesis of the methanofuran precursor gamma-glutamyltyramine and 5-(aminomethyl)-3-furanmethanol-phosphate from tyrosine, glutamate, glyceraldehyde-3-phosphate, and alanine in Methanocaldococcus jannaschii, overview
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate
pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate
show the reaction diagram
L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate
pyruvate + 5-(aminomethyl)-3-furanmethanol-phosphate
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate
pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
a pyridoxal 5'-phosphate protein
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli