Information on EC 2.5.1.B14 - (2E,6E)-farnesyl-diphosphate all-trans-nonaprenyl diphosphate synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.5.1.B14
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
(2E,6E)-farnesyl-diphosphate all-trans-nonaprenyl diphosphate synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + all-trans-nonaprenyl diphosphate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
isoprenoid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 6 isopentenyl units)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
solanesyl diphosphate is a precursor for solanesol biosynthesis. In the solanesol biosynthetic pathway, isopentenyl diphosphate is first isomerised to form dimethylallyl diphosphate by isopentenyl diphosphate isomerase, Ipi, which then binds to isopentenyl diphosphates one by one in the head-tail mode
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
show the reaction diagram
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + all-trans-nonaprenyl diphosphate
show the reaction diagram
6% of the activity with farnesyl diphosphate, OsSPS1
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?
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + ?
show the reaction diagram
6% of the rate with farnesyl diphosphate
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-
?
farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
show the reaction diagram
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + all-trans-nonaprenyl diphosphate
show the reaction diagram
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + all-trans-nonaprenyl diphosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
show the reaction diagram
Q653T6
OsSPS1 is involved in the supply of all-trans-nonaprenyl diphosphate for ubiquinone-9 biosynthesis
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?
farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
show the reaction diagram
Q653T6
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?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + all-trans-nonaprenyl diphosphate
show the reaction diagram
Q653T6
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?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00151
(2E,6E)-farnesyl diphosphate
pH 7.5, 30°C
0.00046
geranylgeranyl diphosphate
pH 7.5, 30°C
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expression is highest in root; high expression level
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
product solanesol is associated with thylakoid membranes
Manually annotated by BRENDA team
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proteolytic modification
isoform SPS1 shows a putative mitochondrial signal peptide sequence
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in yeast