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(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + all-trans-nonaprenyl diphosphate
6% of the activity with farnesyl diphosphate, OsSPS1
-
-
?
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
dimethylallyl diphosphate + isopentenyl diphosphate
diphosphate + ?
6% of the rate with farnesyl diphosphate
-
-
?
farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + all-trans-nonaprenyl diphosphate
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + all-trans-nonaprenyl diphosphate
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
best substrate
products range from C 15 to C45
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
OsSPS1 is involved in the supply of all-trans-nonaprenyl diphosphate for ubiquinone-9 biosynthesis
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
farnesyl diphosphate is the preferred substrate, OsSPS1
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
vmax/Km for (2E,6E)-farnesyl diphosphate is 2.8fold higher than vmax/Km for geranylgeranyl diphosphate
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
-
-
-
-
?
farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
-
-
-
?
farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
farnesyl diphosphate is the preferred acceptor substrate
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + all-trans-nonaprenyl diphosphate
-
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + all-trans-nonaprenyl diphosphate
59.3% of the activity with farnesyl diphosphate, OsSPS1
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + all-trans-nonaprenyl diphosphate
59% of the rate with farnesyl diphosphate
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + all-trans-nonaprenyl diphosphate
cf. EC 2.5.1.84
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
-
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
-
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
-
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
-
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + all-trans-nonaprenyl diphosphate
8.23% of the activity with farnesyl diphosphate, OsSPS1
-
-
?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + all-trans-nonaprenyl diphosphate
8.2% of the rate with farnesyl diphosphate
products range from C 15 to C45
-
?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + all-trans-nonaprenyl diphosphate
vmax/Km for (2E,6E)-farnesyl diphosphate is 2.8fold higher than vmax/Km for geranylgeranyl diphosphate
-
-
?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
-
-
-
-
?
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(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
OsSPS1 is involved in the supply of all-trans-nonaprenyl diphosphate for ubiquinone-9 biosynthesis
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + all-trans-nonaprenyl diphosphate
-
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + all-trans-nonaprenyl diphosphate
-
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + solanesyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
-
-
-
-
?
dimethylallyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + solanesyl diphosphate
-
-
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
-
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
-
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
?
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
-
geranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + solanesyl diphosphate
-
-
-
-
-
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + solanesyl diphosphate
-
-
-
-
?
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metabolism
solanesyl diphosphate is a precursor for solanesol biosynthesis. In the solanesol biosynthetic pathway, isopentenyl diphosphate is first isomerised to form dimethylallyl diphosphate by isopentenyl diphosphate isomerase, Ipi, which then binds to isopentenyl diphosphates one by one in the head-tail mode
metabolism
-
key enzyme for the biosynthesis of solanesol
metabolism
-
key enzyme for the biosynthesis of solanesol
metabolism
-
key enzyme for the biosynthesis of solanesol
metabolism
-
key enzyme for the biosynthesis of solanesol
metabolism
-
solanesyl diphosphate synthase 1 is the key enzyme in solanesol biosynthesis
physiological function
isoform SPS1 is able to complement the yeast coq1 disruptant, which does not form ubiquinone. tranformants produce ubiquinone 9 instead of the native yeast product ubiquinone 6
physiological function
when expressed in Escherichia coli, enzyme extends the prenyl chain length of the endogenous ubiquinone to nine isoprene units respectively. In planta, constitutive overexpression elevates the plastoquinone content of immature tobacco leaves. Virus-induced gene silencing shows that the enzyme is necessary for normal chloroplast structure and function. Plants silenced for SPS are photobleached and accumulate phytoene
physiological function
-
isoform SPS1 overexpression significantly increases leaf growth, photosynthesis, and chlorophyll content
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Ohara, K.; Sasaki, K.; Yazaki, K.
Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa
J. Exp. Bot.
61
2683-2692
2010
Oryza sativa, Oryza sativa (Q653T6)
brenda
Jones, M.; Perez-Fons, L.; Robertson, F.; Bramley, P.; Fraser, P.
Functional characterization of long-chain prenyl diphosphate synthases from tomato
Biochem. J.
449
729-740
2013
Solanum lycopersicum (Q09IV6)
brenda
Yan, N.; Liu, Y.; Gong, D.; Du, Y.; Zhang, H.; Zhang, Z.
Solanesol: a review of its resources, derivatives, bioactivities, medicinal applications, and biosynthesis
Phytochem. Rev.
14
403-417
2015
Oryza sativa (Q653T6)
-
brenda
Yan, N.; Du, Y.; Zhang, H.; Zhang, Z.; Liu, X.; Shi, J.; Liu, Y.
RNA sequencing provides insights into the regulation of solanesol biosynthesis in Nicotiana tabacum induced by moderately high temperature
Biomolecules
8
165
2018
Nicotiana tabacum
brenda
Yan, N.; Liu, Y.; Zhang, H.; Du, Y.; Liu, X.; Zhang, Z.
Solanesol biosynthesis in plants
Molecules
22
510
2017
Arabidopsis thaliana, Solanum lycopersicum, Nicotiana tabacum, Oryza sativa
brenda
Yan, N.; Gai, X.; Xue, L.; Du, Y.; Shi, J.; Liu, Y.
Effects of NtSPS1 overexpression on solanesol content, plant growth, photosynthesis, and metabolome of Nicotiana tabacum
Plants (Basel)
9
518
2020
Nicotiana tabacum
brenda