Information on EC 2.5.1.88 - trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]

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The expected taxonomic range for this enzyme is: Thermobifida fusca

EC NUMBER
COMMENTARY hide
2.5.1.88
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RECOMMENDED NAME
GeneOntology No.
trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + trans,polycis-polyprenyl diphosphate (n: 9-11)
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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Terpenoid backbone biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9–11 isopentenyl units)
Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product [1].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate
n diphosphate + di-trans,poly-cis-polyprenyl diphosphate
show the reaction diagram
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about 35% of the activity with (2Z,6E)-farnesyl diphosphate as allylic substrate
broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product
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?
(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate
n diphosphate + trans,poly-cis-polyprenyl diphosphate
show the reaction diagram
-
highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate
n = 9-11. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product
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?
geranyl diphosphate + n isopentenyl diphosphate
n diphosphate + trans,poly-cis-polyprenyl diphosphate
show the reaction diagram
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about 5% of the activity with (2Z,6E)-farnesyl diphosphate as allylic substrate
broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product
-
?
geranylgeranyl diphosphate + n isopentenyl diphosphate
n diphosphate + tri-trans,poly-cis-polyprenyl diphosphate
show the reaction diagram
-
about 30% of the activity with (2Z,6E)-farnesyl diphosphate as allylic substrate
broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product
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?
neryl diphosphate + n isopentenyl diphosphate
n diphosphate + poly-cis-polyprenyl diphosphate
show the reaction diagram
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about 10% of the activity with (2Z,6E)-farnesyl diphosphate as allylic substrate
broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product
-
?
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
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assay at
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE