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Disease on EC 2.5.1.75 - tRNA dimethylallyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.
African Swine Fever
The African swine fever virus prenyltransferase is an integral membrane trans-geranylgeranyl-diphosphate synthase.
Arthritis, Rheumatoid
Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors.
Blindness
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1.
Cardiomegaly
UBIAD1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats.
Cardiovascular Diseases
Depletion of ubiA prenyltransferase domain containing 1 expression promotes angiotensin II?induced hypertrophic response in AC16 human myocardial cells via modulating the expression levels of coenzyme Q10 and endothelial nitric oxide synthase.
Choroideremia
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics.
Corneal Dystrophies, Hereditary
A Mouse Model of Schnyder Corneal Dystrophy with the N100S Point Mutation.
A mutation in the UBIAD1 gene in a Han Chinese family with Schnyder corneal dystrophy.
In Vivo Laser Confocal Microscopy Findings and Mutational Analysis for Schnyder's Crystalline Corneal Dystrophy.
Long-Term Outcome After Penetrating Keratoplasty in a Pedigree With the G177E Mutation in the UBIAD1 Gene for Schnyder Corneal Dystrophy.
Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy.
Phenotype-genotype correlation in patients with schnyder corneal dystrophy.
Schnyder Corneal Dystrophy-Associated UBIAD1 is Defective in MK-4 Synthesis and Resists Autophagy-Mediated Degradation.
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1.
UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy.
creatine kinase deficiency
Manipulation of cytokinin level in the ergot fungus Claviceps purpurea emphasizes its contribution to virulence.
Epilepsies, Myoclonic
Noninvasive diagnosis of TRIT1-related mitochondrial disorder by measuring i6 A37 and ms2 i6 A37 modifications in tRNAs from blood and urine samples.
Epilepsy
Matchmaking facilitates the diagnosis of an autosomal-recessive mitochondrial disease caused by biallelic mutation of the tRNA isopentenyltransferase (TRIT1) gene.
Genetic Diseases, Inborn
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1.
Hepatitis C
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Hypercholesterolemia
The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.
Infections
Further investigations of race:cultivar-specific induction of enzymes related to phytoalexin biosynthesis in soybean roots following infection with Phytophthora megasperma f.sp. glycinea.
Intestinal Volvulus
Protein prenyltransferases: anchor size, pseudogenes and parasites.
Ischemic Stroke
Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia.
Leukemia, Myeloid, Acute
Is there a future for prenyltransferase inhibitors in cancer therapy?
Lung Neoplasms
Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.
Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer.
Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer.
The human tRNA-modifying protein, TRIT1, forms amyloid fibers in vitro.
Lymphatic Metastasis
Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.
Malaria
Characterization of a PRL protein tyrosine phosphatase from Plasmodium falciparum.
Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue.
Melanoma
Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3' untranslated region of TRIT1.
Microcephaly
Matchmaking facilitates the diagnosis of an autosomal-recessive mitochondrial disease caused by biallelic mutation of the tRNA isopentenyltransferase (TRIT1) gene.
Mitochondrial Diseases
Matchmaking facilitates the diagnosis of an autosomal-recessive mitochondrial disease caused by biallelic mutation of the tRNA isopentenyltransferase (TRIT1) gene.
Noninvasive diagnosis of TRIT1-related mitochondrial disorder by measuring i6 A37 and ms2 i6 A37 modifications in tRNAs from blood and urine samples.
The first Korean cases of combined oxidative phosphorylation deficiency 35 with two novel TRIT1 mutations in two siblings confirmed by clinical and molecular investigation.
The modified base isopentenyladenosine and its derivatives in tRNA.
Neoplasm Metastasis
Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.
Neoplasms
A New Horizon in Vitamin K Research.
Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3' untranslated region of TRIT1.
Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.
Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter.
Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.
Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.
Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis.
Functional study of SCCD pathogenic gene UBIAD1 (Review).
Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer.
Human cells have a limited set of tRNA anticodon loop substrates of the tRNA isopentenyltransferase TRIT1 tumor suppressor.
Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer.
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
Inhibitors of farnesyltransferase and geranylgeranyltransferase-I for antitumor therapy: substrate-based design, conformational constraint and biological activity.
Is there a future for prenyltransferase inhibitors in cancer therapy?
Molecular targets for altering radiosensitivity: lessons from Ras as a pre-clinical and clinical model.
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases.
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Protein prenylation: enzymes, therapeutics, and biotechnology applications.
The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer.
The human tRNA-modifying protein, TRIT1, forms amyloid fibers in vitro.
The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain.
The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.
Pancreatic Neoplasms
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
Parasitic Diseases
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Protein prenylation: enzymes, therapeutics, and biotechnology applications.
Protein prenyltransferases: anchor size, pseudogenes and parasites.
Progeria
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Protein prenylation: enzymes, therapeutics, and biotechnology applications.
Prostatic Neoplasms
The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.
Seizures
Noninvasive diagnosis of TRIT1-related mitochondrial disorder by measuring i6 A37 and ms2 i6 A37 modifications in tRNAs from blood and urine samples.
Stomach Neoplasms
Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population.
Virus Diseases
Protein prenylation: enzymes, therapeutics, and biotechnology applications.