Information on EC 2.5.1.58 - protein farnesyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.5.1.58
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RECOMMENDED NAME
GeneOntology No.
protein farnesyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
show the reaction diagram
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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Terpenoid backbone biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
farnesyl-diphosphate:protein-cysteine farnesyltransferase
This enzyme, along with protein geranylgeranyltransferase types I (EC 2.5.1.59) and II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction. A zinc metalloenzyme that requires Mg2+ for activity.
CAS REGISTRY NUMBER
COMMENTARY hide
131384-38-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
alpha-subunit and beta-subunit
Q9Y765 AND A0A0A6KLS8
UniProt
Manually annotated by BRENDA team
clinical isolate
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Manually annotated by BRENDA team
clinical isolate
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain LV78
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Manually annotated by BRENDA team
strain LV78
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Manually annotated by BRENDA team
BY-2 cells
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
4-week-old hydroponically grown tomato plants, VFNT cherry
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Manually annotated by BRENDA team
tachyzoites of the RH strain were grown and maintained in Cercopithecus aethiops kidney cells
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1E)-1-[(2E,6E,10E)-12-azido-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]-2-oxodiphosphane + protein-cysteine
?
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(2,3,5,6-tetrafluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2,3,5,6-tetrafluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(phenylamino)octa-2,6-dien-1-yl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-(phenylamino)octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(phenylsulfanyl)octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-(phenylsulfanyl)octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CCIQ
?
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CGGDD
?
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CSVL
?
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CTIQ
?
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVIS
?
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVLL
?
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVLS
?
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-phenoxyocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-phenoxyocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[(2-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(2-methylphenyl)amino]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[(3,4,5-trimethoxybenzyl)oxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(3,4,5-trimethoxybenzyl)oxy]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[(3-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(3-methylphenyl)amino]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[(4-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(4-methylphenyl)amino]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[(4-nitrophenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(4-nitrophenyl)amino]octa-2,6-dien-1-y)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[3-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[3-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethyl)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[4-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[4-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[4-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[4-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[[2-(trifluoromethyl)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[[2-(trifluoromethyl)phenyl]amino]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[[3-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[[3-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-8-[[4-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[[4-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-3,7-dimethyl-9-phenylnona-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-9-phenylnona-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-8-(2,3-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2,3-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
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?
(2E,6E)-8-(2,6-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2,6-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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-
-
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?
(2E,6E)-8-(2-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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-
-
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?
(2E,6E)-8-(2-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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-
-
-
?
(2E,6E)-8-(2-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yll)CVLS + diphosphate
show the reaction diagram
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-
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?
(2E,6E)-8-(2-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-8-(3,4-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3,4-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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?
(2E,6E)-8-(3,4-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3,4-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(3,5-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3,5-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(3,5-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3,5-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(3-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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-
-
-
?
(2E,6E)-8-(3-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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-
-
-
?
(2E,6E)-8-(3-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
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-
-
-
?
(2E,6E)-8-(3-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yll)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(3-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(4-benzylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-benzylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(4-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(4-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(4-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(4-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yll)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(4-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(4-nitrophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-nitrophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(benzyloxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(benzyloxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-(isoxazol-3-ylamino)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(isoxazol-3-ylamino)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(2-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(2-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(2-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(2-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(2-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(2-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(3-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(3-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(3-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(3-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(3-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(3-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(4-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(4-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(4-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(4-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[(4-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[3-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[3-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-8-[4-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[4-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine
S-(2E,6E)-farnesyl protein + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + CCIQ
S-(2E,6E)-farnesyl-CCIQ + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + CGGDD
S-(2E,6E)-farnesyl-CGGDD + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + CSVL
S-(2E,6E)-farnesyl-CSVL + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + CTIQ
S-(2E,6E)-farnesyl-CTIQ + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + CVIS
S-(2E,6E)-farnesyl-CVIS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + CVLL
S-(2E,6E)-farnesyl-CVLL + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + CVLS
S-(2E,6E)-farnesyl-CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + dansyl-CGVLS
dansyl-G-(S-(2E,6E)-farnesyl)CVLS
show the reaction diagram
-
assay at pH 7.5, 37C
-
-
?
(2E,6E)-farnesyl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-farnesyl)CVLS
show the reaction diagram
-
assay at pH 7.5, 30C
-
-
?
(2E,6E)-farnesyl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-farnesyl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + K Ras-cysteine
S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate
show the reaction diagram
-
-
-
?
(2E,6E)-farnesyl diphosphate + KGCVIM
S-(2E,6E)-farnesyl-KGCVIM + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + KGCVVM
S-(2E,6E)-farnesyl-KGCVVM + diphosphate
show the reaction diagram
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + [H Ras]-L-cysteine
S-(2E,6E)-farnesyl-[H Ras]-L-cysteine + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + [K Ras]-L-cysteine
S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + [N Ras]-L-cysteine
S-(2E,6E)-farnesyl-[N Ras]-L-cysteine + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
[protein]-S-((2E,6E)-farnesyl)-L-cysteine + diphosphate
show the reaction diagram
-
assay at pH 7.5, 30C
-
-
?
(2E,6E)-farnesyl diphosphate + [Rho]-L-cysteine
S-(2E,6E)-farnesyl-[Rho]-L-cysteine + diphosphate
show the reaction diagram
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CCIQ
?
show the reaction diagram
-
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CGGDD
?
show the reaction diagram
-
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CSVL
?
show the reaction diagram
-
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CTIQ
?
show the reaction diagram
-
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVIS
?
show the reaction diagram
-
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVLL
?
show the reaction diagram
-
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVLS
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CCIQ
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CGGDD
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CSVL
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CTIQ
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVIS
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVLL
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVLS
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CCIQ
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CGGDD
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CSVL
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CTIQ
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVIS
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVLL
?
show the reaction diagram
-
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVLS
?
show the reaction diagram
-
-
-
-
?
(2Z)-geranylgeranyl diphosphate + protein cysteine
diphosphate + S-(2Z)-geranylgeranylcysteinyl protein
show the reaction diagram
-
-
-
-
?
10-benzyloxy-3-methyl-2-decen-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(10-benzyloxy-3-methyl-2-decenyl)-Cys-Val-Leu-Ser
show the reaction diagram
-
-
-
-
?
12-propargoxyfarnesyl diphosphate + N-dansyl-Gly-Cys-Val-Ile-Ala-OH
diphosphate + propargoxyfarnesyl N-dansyl-Gly-Cys-Val-Ile-Ala-OH
show the reaction diagram
-
-
-
-
?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Lys-Thr-Gln
? + diphosphate
show the reaction diagram
-
-
-
-
?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Lys-Val-Leu
? + diphosphate
show the reaction diagram
-
-
-
-
?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Val-Ile-Met
? + diphosphate
show the reaction diagram
-
-
-
-
?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Val-Leu-Ser
? + diphosphate
show the reaction diagram
-
-
-
-
?
3-(azidomethyl)-N-[(2E,6E,8E)-2,6-dimethyl-8-(oxodiphosphanylidene)octa-2,6-dien-1-yl]aniline + protein-cysteine
?
show the reaction diagram
-
-
-
-
?
3-(azidomethyl)-N-[(4E,8E,10E)-4,8-dimethyl-10-(oxodiphosphanylidene)deca-4,8-dien-1-yl]aniline + protein-cysteine
?
show the reaction diagram
-
-
-
-
?
6-benzyloxy-3-methyl-2-hexen-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(6-benzyloxy-3-methyl-2-hexenyl)-Cys-Val-Leu-Ser
show the reaction diagram
-
-
-
-
?
7-benzyloxy-3-methyl-2-hepten-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(7-benzyloxy-3-methyl-2-heptenyl)-Cys-Val-Leu-Ser
show the reaction diagram
-
-
-
-
?
8-benzyloxy-3-methyl-2-octen-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(8-benzyloxy-3-methyl-2-octenyl)-Cys-Val-Leu-Ser
show the reaction diagram
-
-
-
-
?
9-benzyloxy-3-methyl-2-nonen-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(9-benzyloxy-3-methyl-2-nonenyl)-Cys-Val-Leu-Ser
show the reaction diagram
-
-
-
-
?
AAA-GPP + N-dansyl-GCVLS
?
show the reaction diagram
-
-
-
-
?
APO-GPP + N-dansyl-GCVLS
?
show the reaction diagram
-
-
-
-
?
CALQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CALQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CALV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CALV + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CAVQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CAVQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CCIF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CCIF + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CCIL + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CCIL + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CDVK + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CDVK + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CEIQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CEIQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CFLS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CFLS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CFPS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CFPS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CFTN + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CFTN + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CFVN + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CFVN + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CGIA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGIA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CGIM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGIM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CGLF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGLF + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CGLY + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGLY + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CGVV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGVV + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CHIM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHIM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CHIQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHIQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CHLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHLM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CHLS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHLS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CHVM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHVM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CHVQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHVQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CIVA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CIVA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CKIF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CKIF + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CKIS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CKIS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CKIV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CKIV + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CLIT + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLIT + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CLLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLLM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CLLV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLLV + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CLML + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLML + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CLTS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLTS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CLVM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLVM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CNIM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNIM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CNLF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNLF + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CNLK + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNLK + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CNLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNLM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CNLQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNLQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CQTA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CQTA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CRIS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CRIS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSFM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSFM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSIM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSIM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSIS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSIS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSLA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSLC + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLC + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSLG + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLG + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSLH + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLH + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSVQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSVQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CSVS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSVS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTII + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTII + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTIV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTIV + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTKF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTKF + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTLA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTLA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTLM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTLQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTLQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTMS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTMS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTTQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTTQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTVF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTVF + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTVS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTVS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CTVV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTVV + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CVHF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVHF + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CVLA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVLA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CVLH + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVLH + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CVLQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVLQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CVQM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVQM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CVVT + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVVT + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CYIS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CYIS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CYLA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CYLA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CYPD + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CYPD + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
CYVM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CYVM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVAA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVAA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVAM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVAM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVAQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVAQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVAS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVAS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVCA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVCA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVCM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVCM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVCQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVCQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVCS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVCS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVDA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVDM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVDQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVDS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDS + diphosphate
show the reaction diagram
dansyl-GCVEA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVEA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVEM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVEM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVEQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVEQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVES + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVES + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVFA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVFA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVFM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVFM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVFQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVFQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVFS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVFS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVGA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVGA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVGM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVGM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVGQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVGQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVGS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVGS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVHA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVHA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVHM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVHM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVHQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVHQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVHS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVHS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVIA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIA + diphosphate
show the reaction diagram
dansyl-GCVIA + 1-(4,5-dimethoxy-nitrophenyl)ethyl (2E,6E)-farnesyl diphosphate
?
show the reaction diagram
-
7.6% enzyme activity, specific activity 0.058 microM/min
-
-
?
dansyl-GCVIA + 2-nitrophenyl (2E,6E)-farnesyl diphosphate
?
show the reaction diagram
-
14% enzyme activity, specific activity 0.104 microM/min
-
-
?
dansyl-GCVIM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVIQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVIS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVKA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVKLQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVKM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVKQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVKS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKS + diphosphate
show the reaction diagram
dansyl-GCVLA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVLM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVLS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLS + diphosphate
show the reaction diagram
dansyl-GCVLS + (E)-[4-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]phenyl]-methanyl diphosphate
dansyl-G-(S-(E)-[4-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]phenyl]-methanyl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
dansyl-GCVLS + [3-[(3-phenoxyphenoxy)methyl]phenyl]-methanyl diphosphate
dansyl-G-(S-[3-[(3-phenoxyphenoxy)methyl]phenyl]-methanyl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
dansyl-GCVMA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVMA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVMM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVMM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVMQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVMQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVMS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVMS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVNA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVNA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVNM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVNM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVNQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVNQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVNS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVNS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVPA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVPA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVPM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVPM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVPQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVPQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVPS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVPS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVQA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVQA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVQM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVQM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVQQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVQQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVQs + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVQS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVSA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVSA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVSM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVSM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVSQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVSQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVSS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVSS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVTA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVTA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVTM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVTM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVTQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVTQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVTS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVTS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVVA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVVA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVVM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVVM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVVQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVVQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVVS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVVS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVWA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVWA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVWM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVWM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVWQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVWQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVWS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVWS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVYA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVYA + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVYM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVYM + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVYQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVYQ + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
dansyl-GCVYS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVYS + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
decadienyl azide diphosphate + protein-cysteine
?
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + biotin-YRASNRSCAIM
diphosphate + biotin-YRASNRS-(S-farnesyl)CAIM
show the reaction diagram
farnesyl diphosphate + dansyl-GCVLS
diphosphate + S-farnesyl dansyl-GCVLS
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + dansyl-Gly-Cys-Lys-Thr-Gln
dansyl-Gly-S-farnesyl-Cys-Lys-Thr-Gln + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + dansyl-Gly-Cys-Lys-Val-Leu
dansyl-Gly-S-farnesyl-Cys-Lys-Val-Leu + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + dansyl-Gly-Cys-Val-Ile-Met
dansyl-Gly-S-farnesyl-Cys-Val-Ile-Met + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + dansyl-Gly-Cys-Val-Leu-Ser
dansyl-Gly-S-farnesyl-Cys-Val-Leu-Ser + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + Ds-GCVIA
diphosphate + ?
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + GCVLS
Gly-S-farnesyl-Cys-Val-Leu-Ser + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + GST-CIIL
diphosphate + S-farnesyl-GST-Cys-Ile-Ile-Ser
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + GST-Cys-Ile-Ile-Ser
diphosphate + S-farnesyl-GST-Cys-Ile-Ile-Ser
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + human recombinant wild-type H-Ras-CVLS
diphosphate + ?
show the reaction diagram
-
-
-
?
farnesyl diphosphate + mutant H-Ras-CVLL
diphosphate + ?
show the reaction diagram
20fold less active than human recombinant wild-type H-Ras-CVLS
-
-
-
farnesyl diphosphate + N-dansyl-GCVLS
?
show the reaction diagram
-
assay at pH 7.5, 30C
-
-
?
farnesyl diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-farnesyl-Cys-Val-Leu-Ser
show the reaction diagram
-
the best substrate
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
show the reaction diagram
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
show the reaction diagram
farnesyl diphosphate + Ras oncoprotein p21
diphosphate + Ras-S-farnesyl oncoprotein p21
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + Ras protein
diphosphate + S-farnesyl Ras protein
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + Ras-Cys-Val-Ile-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met
show the reaction diagram
farnesyl diphosphate + Ras-Cys-Val-Leu-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Leu-Met
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Ile-Leu
Thr-Lys-S-farnesyl-Cys-Val-Ile-Leu + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Ile-Met
Thr-Lys-S-farnesyl-Cys-Val-Ile-Met + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Ile-Phe
Thr-Lys-S-farnesyl-Cys-Val-Ile-Phe + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Ile-Ser
Thr-Lys-S-farnesyl-Cys-Val-Ile-Ser + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Leu-Ala
Thr-Lys-S-farnesyl-Cys-Val-Leu-Ala + diphosphate
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + [protein]-L-cysteine
[protein]-S-((2E,6E)-farnesyl)-L-cysteine + diphosphate
show the reaction diagram
-
assay at pH 7.8, 25C
-
-
?
farnesyl monophosphate + Gly-Cys-Val-Leu-Ser
phosphate + Gly-S-farnesyl-Cys-Val-Leu-Ser
show the reaction diagram
-
-
-
-
?
farnesyl triphosphate + Ras-Cys-Val-Ile-Met
triphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met
show the reaction diagram
-
-
-
-
?
geranyl alkyne diphosphate + N-dansyl-GCVIA
N-dansyl-G-(alkyne geranyl)CVIA + diphosphate
show the reaction diagram
-
-
-
-
ir
geranyl diphosphate + dansyl-GCVLS
dansyl-G-(S-geranyl)CVLS + diphosphate
show the reaction diagram
-
-
-
-
?
geranylgeranyl diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-geranylgeranyl-Cys-Val-Leu-Ser
show the reaction diagram
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
diphosphate + S-geranylgeranylcysteinyl protein
show the reaction diagram
-
-
-
-
?
HOM-GPP + N-dansyl-GCVLS
?
show the reaction diagram
-
-
-
-
?
TKCVIA + farnesyl diphosphate
TK-(S-farnesyl)CVIA + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIC + farnesyl diphosphate
diphosphate + ?
show the reaction diagram
-
-
-
-
?
TKCVID + farnesyl diphosphate
TK-(S-farnesyl)CVID + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIF + farnesyl diphosphate
TK-(S-farnesyl)CVIF + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVII + farnesyl diphosphate
TK-(S-farnesyl)CVII + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIL + farnesyl diphosphate
TK-(S-farnesyl)CVIL + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIM + farnesyl diphosphate
TK-(S-farnesyl)CVIM + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIN + farnesyl diphosphate
TK-(S-farnesyl)CVIN + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIQ + farnesyl diphosphate
TK-(S-farnesyl)CVIQ + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIR + farnesyl diphosphate
TK-(S-farnesyl)CVIR + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIS + farnesyl diphosphate
TK-(S-farnesyl)CVIS + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIT + farnesyl diphosphate
TK-(S-farnesyl)CVIT + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIV + farnesyl diphosphate
TK-(S-farnesyl)CVIV + diphosphate
show the reaction diagram
-
-
-
-
?
TKCVIY + farnesyl diphosphate
TK-(S-farnesyl)CVIY + diphosphate
show the reaction diagram
-
-
-
-
?
YRASNRSCAIM + farnesyl diphosphate
YRASNRS-(S-farnesyl)CAIM + diphosphate
show the reaction diagram
-
-
-
-
?
[(4E,8E,10E)-4,8-dimethyl-10-(oxodiphosphanylidene)deca-4,8-dien-1-yl]oxyacetonitrile + protein-cysteine
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine
S-(2E,6E)-farnesyl protein + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + [H Ras]-L-cysteine
S-(2E,6E)-farnesyl-[H Ras]-L-cysteine + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + [K Ras]-L-cysteine
S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + [N Ras]-L-cysteine
S-(2E,6E)-farnesyl-[N Ras]-L-cysteine + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + [Rho]-L-cysteine
S-(2E,6E)-farnesyl-[Rho]-L-cysteine + diphosphate
show the reaction diagram
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
show the reaction diagram
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cd2+
-
substitution of the active site zinc with cadmium increases the affinity of the peptide substrate and decreases the rate constant for the chemical step
Mn2+
-
in wild type FTase, Mg2+ can be replaced by Mn2+ with a 2-fold lower KMn2+ 2 mM
Zn
-
dependent
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-6-(camphorquinone-10-sulfonamido)-hexanoic acid
-
-
(-)-6-(camphorquinone-10-sulfonamido)-hexanoic acid
-
-
(1aR,2S,3aS,6aR,7aR)-2,6-dimethyl-1a-[(1E)-3-oxobut-1-en-1-yl]octahydro-5H-oxireno[4,5]cyclohepta[1,2-b]furan-5-one
-
-
(1aR,2S,3aS,6aR,7aR)-2-methyl-6-methylidene-1a-[(1E)-3-oxobut-1-en-1-yl]octahydro-5H-oxireno[4,5]cyclohepta[1,2-b]furan-5-one
-
-
(1aS,2S,3aS,6aR,7aS)-2,6-dimethyl-1a-[(1E)-3-oxobut-1-en-1-yl]octahydro-5H-oxireno[4,5]cyclohepta[1,2-b]furan-5-one
-
-
(1aS,2S,3aS,6aR,7aS)-2-methyl-6-methylidene-1a-[(1E)-3-oxobut-1-en-1-yl]octahydro-5H-oxireno[4,5]cyclohepta[1,2-b]furan-5-one
-
-
(1R,4aR,5R,7S)-5-[[(1R,4aR,8aS)-8a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-6-methoxy-5,8-dioxo-1,4,4a,5,8,8a-hexahydronaphthalen-1-yl]methyl]-7-hydroxy-1,4a-dimethyl-6-methylidenedecahydronaphthalene-1-carbaldehyde
-
-
(1R,4aR,5R,7S)-5-[[(1R,4aR,8aS)-8a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-6-methoxy-5,8-dioxo-1,4,4a,5,8,8a-hexahydronaphthalen-1-yl]methyl]-7-hydroxy-1,4a-dimethyl-6-methylidenedecahydronaphthalene-1-carboxylic acid
-
-
(2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetic acid
(2E)-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]butanedioic acid
(2E)-3-[(3aR,7S,8aS)-3,7-dimethyl-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]-1-methylprop-2-en-1-yl acetate
-
-
(2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid
(2Z)-3-(1H-imidazol-2-yl)-5-methylhexa-2,4-dienoic acid
-
8% inhibition at 0.001 M
(2Z)-5-methyl-3-(1-methyl-1H-imidazol-2-yl)hexa-2,4-dienoic acid
-
8% inhibition at 0.001 M
(2Z,4E)-5,9-dimethyl-3-(1-methyl-1H-imidazol-2-yl)deca-2,4,8-trienoic acid
-
-
(2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoic acid
(2Z,6E)-3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2,6,10-triene monophosphate
-
IC50: 16 nM
(2Z,6E)-3-allyl-7,11-dimethyldodeca-2,6,10-trien-1-yl 5-nitrofurfuryl N-methyl-N-(4-chlorobutyl)phosphoramidate
-
-
(2Z,6E)-3-allyl-7,11-dimethyldodeca-2,6,10-triene monophosphate
-
-
(2Z,6E)-3-tert-butyl-7,11-dimethyldodeca-2,6,10-trien-1-yl 5-nitrofurfuryl N-methyl-N-(4-chlorobutyl)phosphoramidate
-
-
(2Z,6E)-3-tert-butyl-7,11-dimethyldodeca-2,6,10-triene monophosphate
-
IC50: 13 nM
(2Z,6E,10E)-3-(3-methyl-1-but-2-enyl)-7,11-dimethyldodeca-2,6,10-trien-1-yl 5-nitrofurfuryl N-methyl-N-(4-chlorobutyl)phosphoramidate
-
-
(3aR,7S,8aS)-3,7-dimethyl-6-[(1E)-3-oxobut-1-en-1-yl]-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
-
-
(3aR,7S,8aS)-6-[(1E)-3-hydroxybut-1-en-1-yl]-3,7-dimethyl-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
-
-
(3aR,7S,8aS)-7-methyl-3-methylidene-6-[(1E)-3-oxobut-1-en-1-yl]-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
-
-
(3aR,8S,9aS)-6-acetyl-3,8-dimethyl-3,3a,4,8,9,9a-hexahydro-2H-cyclohepta[1,2-b:4,5-b']difuran-2-one
-
-
(3R,3aR,7S,8aS)-3,7-dimethyl-6-(3-oxobutyl)-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
-
-
(3R,3aR,7S,8aS)-6-(3-hydroxybutyl)-3,7-dimethyl-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
-
-
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxy-5-[[(1S,3S,7S,8aS)-1,3,7-trihydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
-
-
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxy-6-methyl-5-[[(1R,8aS)-5,5,8a-trimethyl-2-methylidene-3-oxodecahydronaphthalen-1-yl]methyl]-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
-
-
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-5-[[(1R,3S,5R,8aS)-3-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-2-methoxy-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
-
-
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-5-[[(1R,3S,7S,8aS)-3,7-dihydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-2-methoxy-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
-
-
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-5-[[(1R,3S,8aS)-3-hydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-2-methoxy-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
-
-
(4aS,5R,8aR)-4a-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxy-6-methyl-5-[[(1R,8aS)-5,5,8a-trimethyl-2-methylidene-3-oxodecahydronaphthalen-1-yl]methyl]-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
-
-
(4aS,5S,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-5-[[(1R,2R,7S,8aS)-2,7-dihydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]methyl]-6-hydroxy-2-methoxy-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
-
-
(4E)-5,9-dimethyl-3-(1-methyl-1H-imidazol-2-yl)deca-4,8-dienoic acid
-
-
(4E,8E)-2-(ethoxycarbonyl)-5,9,13-trimethyl-2-[3-(1-methyl-1H-imidazol-2-yl)propyl]tetradeca-4,8,12-trienoic acid
(4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-4,8,12-trienoic acid
(4E,8E)-5,9,13-trimethyl-N-(phenylsulfonyl)tetradeca-4,8,12-trienamide
(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienamide
-
-
(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid
(4E,8E)-N-hydroxy-5,9,13-trimethyltetradeca-4,8,12-trienamide
-
-
(4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid
(6E,10E)-7,11,15-trimethyl-3-oxohexadeca-6,10,14-trienoic acid
(7E,11E)-8,12,16-trimethyl-4-oxoheptadeca-7,11,15-trienoic acid
(E,E)-8-O-(3-benzoylbenzyl)-3,7-dimethyl-2,6-octadiene 1-diphosphate
-
-
(E,E)-8-O-(4-benzoylbenzyl)-3,7-dimethyl-2,6-octadiene 1-diphosphate
-
-
(S)-N-(4-(3,4-dichlorophenoxy)benzyl)-6-(1H-indol-3-yl)piperazine-2,5-dione
-
dual inhibitor for both farnesyl transferase and geranygeranyltransferase-I. Compound occupies both isoprenoid and peptide substrate binding sites
(S)-N-(4-(3-chlorophenoxy)benzyl)-6-(1H-indol-3-yl)piperazine-2,5-dione
-
dual inhibitor for both farnesyl transferase and geranygeranyltransferase-I
1,4,8,10-tetrahydroxy-6-[(1E)-3-[(3S,8aS)-3-hydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]-1-methylprop-1-en-1-yl]-5,6-dihydro-7H-benzo[c]xanthen-7-one
-
-
1,5-dimethyl-1H-imidazole-4-sulfonic acid (5-bromo-2-fluorobenzyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide
-
98% inhibition at 50 nM
1,5-dimethyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-ethanesulfonyl-benzyl)-amide
-
97% inhibition at 50 nM
1,5-dimethyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide
-
92% inhibition at 50 nM
1-(1-[3,4-bis[(hydroxyacetyl)amino]phenyl]-4,4-dicyano-1-oxobut-3-en-2-yl)-3-(dimethylamino)pyridinium
-
-
1-(1H-imidazol-5-ylmethyl)-7-pyridin-4-yl-4-[[2-(trifluoromethoxy)phenyl]carbonyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine
-
-
1-(2-chlorophenyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[4-(methylsulfonyl)benzyl]methanesulfonamide
-
99% inhibition at 50 nM
1-(4,4-dicyano-1-oxo-1-phenylbut-3-en-2-yl)-3-(dimethylamino)pyridinium
-
-
1-(4,4-dicyano-1-oxo-1-phenylbut-3-en-2-yl)-3-methylpyridinium
-
-
1-methyl-1H-imidazole-4-sulfonic acid (2-bromo-allyl)-[1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-amide
-
97% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid (2-bromo-allyl)-[6-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide
-
94% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid (4-benzenesulfonylbenzyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide
-
99% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid (4-methanesulfonylbenzyl)-[1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-amide
-
98% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid benzyl-[6-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide
-
93% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid ethyl-[1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydro-quinolin-3-yl]amide
-
86% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-pyrrol-1-yl-ethyl)-amide
-
90% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-yl-methyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(3-methoxy-propyl)-amide
-
-
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathin-7-ylmethyl)-amide
-
99% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-ethanesulfonyl-benzyl)-amide
-
complete inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-fluoro-benzyl)-amide
-
99% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide
-
complete inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(5-trifluoromethyl-furan-2-ylmethyl)-amide
-
97% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[2-(2-fluoro-phenyl)-ethyl]-amide
-
complete inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-amide
-
99% inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[2-(4-fluoro-phenyl)-ethyl]-amide
-
complete inhibition at 50 nM
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyl]-amide
-
99% inhibition at 50 nM
1-methyl-1H-pyrazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-fluoro-benzyl)-amide
-
94% inhibition at 50 nM
1-methyl-N-(2-methylbenzyl)-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-1H-imidazole-4-sulfonamide
-
46% inhibition at 50 nM
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-1H-imidazole-4-sulfonamide
-
80% inhibition at 50 nM
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-methylprop-2-en-1-yl)-1H-imidazole-4-sulfonamide
-
99% inhibition at 50 nM
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-prop-2-en-1-yl-1H-imidazole-4-sulfonamide
-
98% inhibition at 50 nM
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-prop-2-yn-1-yl-1H-imidazole-4-sulfonamide
-
95% inhibition at 50 nM
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-4-yl)methyl]-1H-imidazole-4-sulfonamide
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(methylsulfonyl)ethyl]-1H-imidazole-4-sulfonamide
-
99% inhibition at 50 nM
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-[[5-(trifluoromethyl)furan-2-yl]methyl]-1H-imidazole-4-sulfonamide
-
88% inhibition at 50 nM
1-methylethyl 4-[([1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate
1-methylethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
-
97% inhibition at 50 nM
1-[(3aR,7S,8aS)-3,7-dimethyl-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]-3-(1-hydroxyethoxy)butyl acetate
-
-
1-[(3aR,7S,8aS)-3,7-dimethyl-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]butane-1,3-diyl diacetate
-
-
1-[(3aR,7S,8aS)-7-methyl-3-methylidene-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]-3-oxobutyl acetate
-
-
1-[(3aR,7S,8aS)-7-methyl-3-methylidene-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]butane-1,3-diyl diacetate
-
-
1-[(3Z)-1-(4-bromophenyl)-4-cyano-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-1-(4-chlorophenyl)-4-cyano-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-1-[3,4-bis[(hydroxyacetyl)amino]phenyl]-4-cyano-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-4-cyano-1-(3,4-dimethoxyphenyl)-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-methoxypyridinium
-
-
1-[(3Z)-4-cyano-1-(4-cyanophenyl)-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-4-cyano-1-(4-fluorophenyl)-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-4-cyano-5,5-dihydroxy-1-(4-methoxyphenyl)-1-oxohept-3-en-2-yl]-2,4-dimethylpyridinium
-
-
1-[(3Z)-4-cyano-5,5-dihydroxy-1-(4-methoxyphenyl)-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-4-cyano-5,5-dihydroxy-1-(4-methoxyphenyl)-1-oxohept-3-en-2-yl]-3-methoxypyridinium
-
-
1-[(3Z)-4-cyano-5,5-dihydroxy-1-(4-methylphenyl)-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-4-cyano-5,5-dihydroxy-1-(4-nitrophenyl)-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-4-cyano-5,5-dihydroxy-1-oxo-1-(3,4,5-trimethoxyphenyl)hept-3-en-2-yl]-2,4-dimethylpyridinium
-
-
1-[(3Z)-4-cyano-5,5-dihydroxy-1-oxo-1-(3,4,5-trimethoxyphenyl)hept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-4-cyano-5,5-dihydroxy-1-oxo-1-phenylhept-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[(3Z)-4-cyano-5,5-dihydroxy-1-oxo-1-phenylhept-3-en-2-yl]-3-methylpyridinium
-
-
1-[1-(4-bromophenyl)-4,4-dicyano-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[1-(4-chlorophenyl)-4,4-dicyano-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[4,4-dicyano-1-(3,4-dimethoxyphenyl)-1-oxobut-3-en-2-yl]-3-methoxypyridinium
-
-
1-[4,4-dicyano-1-(4-cyanophenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[4,4-dicyano-1-(4-fluorophenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[4,4-dicyano-1-(4-methoxyphenyl)-1-oxobut-3-en-2-yl]-2,4-dimethylpyridinium
-
-
1-[4,4-dicyano-1-(4-methoxyphenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[4,4-dicyano-1-(4-methoxyphenyl)-1-oxobut-3-en-2-yl]-3-methoxypyridinium
-
-
1-[4,4-dicyano-1-(4-methylphenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[4,4-dicyano-1-(4-nitrophenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
1-[4,4-dicyano-1-oxo-1-(3,4,5-trimethoxyphenyl)but-3-en-2-yl]-2,4-dimethylpyridinium
-
-
1-[4,4-dicyano-1-oxo-1-(3,4,5-trimethoxyphenyl)but-3-en-2-yl]-3-(dimethylamino)pyridinium
-
-
10-desmethoxystreptonigrin
-
-
18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,5.113,17.07,11.022,26]triaconta-1(26),7,9,13(28),14,16,19,21,22,24,26-undecaene-16-carbonitrile
-
-
2,2,2-trifluoroethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
-
91% inhibition at 50 nM
2-amino-3-[2-butyl-4-(naphthalen-1-ylcarbonyl)piperazin-1-yl]propane-1-thiol
-
-
2-methylpropyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate
-
98% inhibition at 50 nM
2-methylpropyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
2-oxododecanal
-
-
2-[(2E)-3,7-dimethyl-1-(1-methyl-1H-imidazol-2-yl)octa-2,6-dien-1-yl]butanedioic acid
2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]butanedioic acid
2-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](2-fluorobenzyl)amino]-2-oxoethyl acetate
-
33% inhibition at 50 nM
29-oxo-18-oxa-2,6,9,11-tetraazahexacyclo[17.5.3.12,5.113,17.07,11.022,26]nonacosa-7,9,13(28),14,16,19,21,26-octaene-16-carbonitrile
-
-
3,4-dihydro-2H-benzo[b][1,4]dioxepine-7-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide
-
97% inhibition at 50 nM
3-(1H-imidazol-2-yl)-5-methylhex-4-enoic acid
-
21% inhibition at 0.001 M
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate
-
farnesylation of dansyl-GCKVL, IC5=: 510 nM
3-(4-chlorophenyl)-4-cyano-1-methyl-5-[(1-methylethyl)sulfanyl]-1H-pyrrole-2-carboxylic acid
-
-
3-(4-chlorophenyl)-4-cyano-5-(cyclohexylsulfanyl)thiophene-2-carboxylic acid
-
-
3-(4-chlorophenyl)-4-cyano-5-(ethylsulfanyl)thiophene-2-carboxylic acid
-
-
3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid
3-(4-chlorophenyl)-4-cyano-5-(methylsulfanyl)thiophene-2-carboxylic acid
-
-
3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-ylsulfanyl)thiophene-2-carboxylic acid
-
-
3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide
3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
3-(4-chlorophenyl)-4-cyano-5-[(1-methylethyl)sulfanyl]furan-2-carboxylic acid
-
-
3-(4-chlorophenyl)-4-cyano-5-[(1-methylethyl)sulfanyl]thiophene-2-carboxamide
-
-
3-(4-chlorophenyl)-4-cyano-5-[(1-methylethyl)sulfanyl]thiophene-2-carboxylic acid
-
-
3-(4-chlorophenyl)-4-cyano-5-[(1-methylpropyl)sulfanyl]thiophene-2-carboxylic acid
-
-
3-(4-chlorophenyl)-4-cyano-5-[(2-methylpropyl)sulfanyl]thiophene-2-carboxylic acid
-
-
3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide
3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
3-(4-chlorophenyl)-4-cyano-N-cyclopropyl-5-[(1-methylethyl)sulfanyl]thiophene-2-carboxamide
-
-
3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
3-(4-chlorophenyl)-4-ethynyl-5-(2l5-triaz-1-en-2-yn-1-yl)thiophene-2-carboxylic acid
3-(4-chlorophenyl)-4-ethynyl-5-[(1H-imidazol-4-ylacetyl)amino]thiophene-2-carboxylic acid
3-(4-chlorophenyl)-5-([[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl][[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynylthiophene-2-carboxylic acid
3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
3-allylfarnesol
-
potent inhibitor
3-allylfarnesyl diphosphate
-
IC50: 189 nM
3-hydroxy-1-[(3aR,7S,8aS)-7-methyl-3-methylidene-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]butyl acetate
-
-
3-methyl-2-[2-oxo-2-(10H-phenothiazin-10-yl)ethyl]indeno[1,2-c]pyrazol-4(2H)-one
-
most potent in vitro cytostatic activity inhibiting the growth of HCT-116, LOX IMVI and SK-MEL-5 cell lines
3-methyl-3H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide
-
complete inhibition at 50 nM
3-methyl-thiophene-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide
-
97% inhibition at 50 nM
3-oxo-3-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanoic acid
3-tert-butylfarnesyl diphosphate
-
IC50: 31 nM
3-[(tert-butylcarbamoyl-methyl)-(1-methyl-1H-imidazol-4-sulfonyl)-amino]-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-6-carboxylic acid
-
80% inhibition at 50 nM
3-[(tert-butylcarbamoyl-methyl)-(1-methyl-1H-imidazol-4-sulfonyl)-amino]-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-6-carboxylic acid benzylamide
-
59% inhibition at 50 nM
3-[(tert-butylcarbamoyl-methyl)-(1-methyl-1H-imidazol-4-sulfonyl)-amino]-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-6-carboxylic acid tert-butylamide
-
25% inhibition at 50 nM
3-[3-[2-([2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-1-([(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]methyl)ethyl]sulfamoyl)benzyl]phenyl]propanoic acid
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-N-(1-methylpropyl)-1,2,3,4-tetrahydroquinoline-6-carboxamide
-
35% inhibition at 50 nM
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-N,N-diethyl-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide
-
69% inhibition at 50 nM
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-N-(1-methylethyl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide
-
46% inhibition at 50 nM
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-N-cyclohexyl-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide
-
66% inhibition at 50 nM
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-N-methyl-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide
-
69% inhibition at 50 nM
4,4-(biphenyldiglyoxaldehyde)
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-cyclohexylpropanoyl)-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(4-oxopentanoyl)-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(5-oxohexanoyl)-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(6-oxoheptanoyl)-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(cycloheptylcarbonyl)-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(cyclopentylcarbonyl)-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(ethoxyacetyl)-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-hexanoyl-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-N-pyrazin-2-ylpiperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-N-pyridin-3-ylpiperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-[(3,3-dihydroxycyclobutyl)carbonyl]-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-[4-(dimethylamino)-4-oxobutanoyl]-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N-(1-oxidopyridin-3-yl)-1-pentanoylpiperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N-(1H-imidazol-4-ylmethyl)-1-pentanoylpiperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N-(2,5-dihydro-1H-imidazol-5-ylmethyl)-1-pentanoylpiperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N-isoxazol-5-yl-1-pentanoylpiperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N-[2-(1H-imidazol-4-yl)ethyl]-1-pentanoylpiperazine-2-carboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-(1-methylethyl)-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-(2-methylpropyl)-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-(cyclohexylmethyl)-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-butyl-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cycloheptyl-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[(3,5-dimethylisoxazol-4-yl)methyl]piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[2-(1-methyl-1H-imidazol-5-yl)ethyl]piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[2-(1H-imidazol-4-yl)ethyl]piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[2-(6-methylpyridin-3-yl)ethyl]piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[3-(1H-imidazol-4-yl)propyl]piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[3-(2-oxopyrrolidin-1-yl)propyl]piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclopentyl-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclopropyl-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-propyl-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-tert-butyl-N2-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
-
-
4-(3-{[(4-cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-methyl}-phenyl)-pyridine-2-carbonitrile
-
IC50: 0.37 nM, selective inhibitor
4-(4-chlorophenyl)-2-[(1-methylethyl)sulfanyl]-1,3-thiazole-5-carboxylic acid
-
-
4-(4-chlorophenyl)-5-(hydroxyacetyl)-2-[(1-methylethyl)sulfanyl]thiophene-3-carbonitrile
-
-
4-(4-chlorophenyl)-5-(methoxyacetyl)-2-[(1-methylethyl)sulfanyl]thiophene-3-carbonitrile
-
-
4-([(2-carboxy-furan-5-sulfonyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amino]-methyl)-piperidine-1-carboxylic acid methyl ester
-
89% inhibition at 50 nM
4-([(benzo[1,2,5]oxadiazole-4-sulfonyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amino]-methyl)-piperidine-1-carboxylic acid methyl ester
-
99% inhibition at 50 nM
4-([(benzo[1,2,5]thiadiazole-4-sulfonyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amino]-methyl)-piperidine-1-carboxylic acid methyl ester
-
98% inhibition at 50 nM
4-([[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-cyclopropanesulfonyl-amino]-methyl)-piperidine-1-carboxylic acid methyl ester
-
37% inhibition at 50 nM
4-([[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-ethanesulfonyl-amino]-methyl)-piperidine-1-carboxylic acid methyl ester
-
44% inhibition at 50 nM
4-([[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-methanesulfonylmethanesulfonyl-amino]-methyl)-piperidine-1-carboxylic acid methyl ester
-
15% inhibition at 50 nM
4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
4-cyano-3-(3-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
4-cyano-3-(4-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
4-cyano-3-(4-methoxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
4-cyano-3-(dibenzo[b,d]furan-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
4-cyano-3-(naphthalen-2-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
4-cyano-3-[3-(methoxycarbonyl)phenyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophene-2-carboxylic acid
4-ethynyl-5-([[1-(4-nitrobenzyl)-1H-imidazol-5-yl]methyl]amino)-3-phenylthiophene-2-carboxylic acid
4-oxo-4-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]butanoic acid
4-[(3'-Chloro-biphenyl-3-ylmethyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
-
IC50: 0.45 nM, selective inhibitor
4-[(3-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
-
IC50: 0.39 nM, selective inhibitor
4-[(3-Methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
-
IC50: 31 nM
4-[(4-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
-
IC50: 1.5 nM, selective inhibitor
4-[(5-[[4-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)azepan-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
-
-
4-[(5-[[4-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)piperidin-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
-
-
4-[(5-[[4-(5-oxido-7-propyl-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl)azepan-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
-
-
4-[(5-[[4-(7-butyl-5-oxido-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl)azepan-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
-
-
4-[(5-[[4-(7-methyl-5-oxido-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl)azepan-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
-
-
4-[(5-[[4-(7-methyl-5-oxido-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl)piperidin-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
-
-
4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]benzoic acid
-
66% inhibition at 50 nM
4-[2-[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]-2-(1H-imidazol-5-yl)ethyl]benzonitrile
binds into the CAAX peptide site and competes with the CAAX substrate of FTase; binds into the CAAX peptide site and competes with the CAAX substrate of FTase
4-[Biphenyl-3-ylmethyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
-
IC50: 1.5 nM
4-[Hexyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
-
IC50: 1.9 nM
4-[Methyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
-
IC50: 38 nM
4-[N, N -bis((1H-imidazol-4-yl)methyl)aminomethyl]-2-(1-(o-tolyl))benzoylmethionine trifluoroacetate
-
IC50: 1.7 nM
4-[N-(1-H-imidazol-4-yl)methylamino]-2-(2-methoxyphenyl)-benzoylmethionine
-
IC50: 9.5 nM
4-[N-(1-H-imidazol-4-yl)methylamino]-2-(2-methylphenyl)-benzoylmethionine
-
IC50: 2.8 nM
4-[N-(1H-imidazol-4-yl)methylamino]-2-phenylbenzoylmethionine
-
IC50: 28 nM
4-[[(6-cyano-1-pyridin-3-ylmethyl-1,2,3,4-tetrahydro-quinolin-3-yl)-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester
-
35% inhibition at 50 nM
4-[[4-([[4-(4-chlorophenyl)-3-ethynylthiophen-2-yl]amino]methyl)-1H-imidazol-1-yl]methyl]benzonitrile
4-[[5-([4-[7-(3-morpholin-4-ylpropyl)-5-oxido-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl]azepan-1-yl]methyl)-1H-imidazol-1-yl]methyl]benzonitrile
-
-
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(1,5-dimethyl-1H-imidazole-4-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester
-
complete inhibition at 50 nM
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(1,5-dimethyl-1H-imidazole-4-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid tert-butyl ester
-
98% inhibition at 50 nM
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-oxo-2H-chromene-6-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester
-
68% inhibition at 50 nM
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(3,4-dihydro-2H-benzo[b][1,4]dioxepine-7-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester
-
99% inhibition at 50 nM
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(3-methyl-3H-imidazole-4-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester
-
99% inhibition at 50 nM
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid ethylamide
-
98% inhibition at 50 nM
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid isobutyl ester
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide
-
complete inhibition at 50 nM
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N-(1-methylethyl)piperidine-1-carboxamide
-
complete inhibition at 50 nM
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N-ethylpiperidine-1-carboxamide
5,7-dihydroxy-2-[(5R)-1-hydroxy-5-[[(3S,8aS)-3-hydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-2-methoxy-6-methyl-4-oxo-1,5,8,8a-tetrahydronaphthalen-4a(4H)-yl]-4H-chromen-4-one
-
-
5,7-dihydroxy-2-[(5R)-1-hydroxy-5-[[(3S,8aS)-3-hydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-6-methyl-2-oxo-1,5,8,8a-tetrahydronaphthalen-4a(2H)-yl]-4H-chromen-4-one
-
-
5,9,13-trimethyl-8,12-tetradecadiene-2,3-dione
-
0.093 mM causes a 94% reduction in enzyme activity after 30 min
5,9-dimethyl-8-decene-2,3-dione
-
0.017 mM causes a 62% reduction in enzyme activity after 30 min
5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid
5-(butylsulfanyl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid
-
-
5-([[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynyl-3-phenylthiophene-2-carboxylic acid
5-acetyl-4-(4-chlorophenyl)-2-[(1-methylethyl)sulfanyl]thiophene-3-carbonitrile
-
-
5-methyl-3-(1-methyl-1H-imidazol-2-yl)hex-4-enoic acid
-
25% inhibition at 0.001 M
5-oxo-5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentanoic acid
5-[(3-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile
-
IC50: 0.97 nM, selective inhibitor
5-[(4-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile
-
IC50: 10 nM, selective inhibitor
5-[(tert-butoxycarbonyl)[[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylic acid
5-[(tert-butoxycarbonyl)[[1-(4-nitrobenzyl)-1H-imidazol-4-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylic acid
5-[(tert-butoxycarbonyl)[[1-(4-nitrobenzyl)-1H-imidazol-5-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylic acid
5-[4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)carbamoyl]piperazin-1-yl]-5-oxopentyl acetate
-
-
6-([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)hexanamide
-
98% inhibition at 50 nM
6-[(4-hydroxyphenyl)(1H-imidazol-1-yl)methyl]-4-phenyl-1,2-dihydroquinolin-2-ol
-
-
6-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]hexanamide
-
81% inhibition at 50 nM
6-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-pyridine-2-carboxylic acid methyl ester
-
96% inhibition at 50 nM
6-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]pyridine-2-carboxylic acid
-
97% inhibition at 50 nM
ABT-100
-
-
ABT-839
-
-
acetylgliotoxin
-
-
acetylshikonin
actinoplanic acid A
-
-
actinoplanic acid B
-
-
alphabeta-dehydrocurvularin
-
-
andrastin A
-
-
andrastin B
-
-
andrastin C
-
-
asukamycin
-
-
AZD3409
-
-
barceloneic acid A
-
-
benzyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
-
98% inhibition at 50 nM
Biphenyl-3-carboxylic acid (4-cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amide
-
IC50: 14 nM
Biphenyl-3-sulfonic acid (4-cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amide
-
IC50: 18 nM
BMS-214662
BMS-339941
-
-
chaetomellic acid A
chaetomellic acid B
-
-
citreohybridone A
-
-
citreohybridone B
-
-
clavaric acid
-
-
CP-225,917
-
-
CP-263,114
-
-
cylindrol A
-
-
cylindrol A1
-
-
Cys-Val-Phe-aminohexanoate
-
-
Cys-Val-Phe-Cys
-
-
Cys-Val-Phe-Met
-
-
Cys-Val-Phe-Phe
-
-
dehydrascorbic acid 6-palmitate
-
-
deoxyshikonin
desloratadine
-
-
di-tert-butyl 2-[(2E,6E,10E)-1,3,7-trimethyl-1-(1-methyl-1H-imidazol-2-yl)dodeca-2,6,10-trien-1-yl]butanedioate
econazole
-
-
ED5
-
i.e. N-(N-tert-butoxycarbonylpiperidin-4-ylmethyl), N-(2-[((4-cyanophenyl)-3-methyl-3H-imidazol-4-ylmethyl)-amino]-ethyl) 2-methylbenzenesulfonamide, an ethylenediamine-scaffold inhibitor
-
ethyl (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetate
ethyl 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate
ethyl 3-(4-chlorophenyl)-4-cyano-5-[(1-methylethyl)sulfanyl]thiophene-2-carboxylate
-
-
ethyl 3-(4-chlorophenyl)-4-ethynyl-5-(2l5-triaz-1-en-2-yn-1-yl)thiophene-2-carboxylate
ethyl 3-(4-chlorophenyl)-4-ethynyl-5-[(1H-imidazol-4-ylacetyl)amino]thiophene-2-carboxylate
ethyl 3-(4-chlorophenyl)-5-([[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl]amino)-4-ethynylthiophene-2-carboxylate
-
-
ethyl 3-(4-chlorophenyl)-5-([[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl][[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynylthiophene-2-carboxylate
ethyl 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate
ethyl 4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate
ethyl 4-ethynyl-5-([[1-(4-nitrobenzyl)-1H-imidazol-5-yl]methyl]amino)-3-phenylthiophene-2-carboxylate
ethyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate
-
98% inhibition at 50 nM
ethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
ethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
ethyl 5-([[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynyl-3-phenylthiophene-2-carboxylate
ethyl 5-[(tert-butoxycarbonyl)[[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylate
-
-
ethyl 5-[(tert-butoxycarbonyl)[[1-(4-nitrobenzyl)-1H-imidazol-4-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylate
-
-
ethyl 5-[(tert-butoxycarbonyl)[[1-(4-nitrobenzyl)-1H-imidazol-5-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylate
ethyl N-(tert-butoxycarbonyl)-N-[2-(methylsulfanyl)ethyl]glycinate
ethyl N-(tert-butoxycarbonyl)glycinate
ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate
farnesyl diphosphate inhibitor II
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FPT-II
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farnesyltransferase inhibitors I and II
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peptidomimemtic inhibitors, inhibitor I: 50% inhibition at 270 nM, inhibitor II: 50% inhibition at 0.97 nM
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FTI-2148
FTI-2153
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FTI-276
FTI-277
fusidienol
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fusidienol A
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GGTI-297
GGTI-298
gliotoxin
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granaticin A
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granaticin B
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kalafungin
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kampanol A
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kampanol B
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