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Reference on EC 2.5.1.55 - 3-deoxy-8-phosphooctulonate synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Levin, D.H.; Racker, E.
Condensation of arabinose 5-phosphate and phosphorylenol pyruvate by 2-keto-3-deoxy-8-phosphooctonic acid synthetase
J. Biol. Chem.
234
2532-2539
1959
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Levin, D.H.; Racker, E.
2-Keto-3-deoxy-8-phosphooctonic acid synthetase
Methods Enzymol.
8
216-221
1966
Pseudomonas aeruginosa
-
Manually annotated by BRENDA team
Ray, P.
Purification and characterization of 3-deoxy-D-manno-octulosonate 8-phosphate synthetase from Escherichia coli
J. Bacteriol.
141
635-644
1980
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Rick, P.D.; Young, D.A.
Isolation and characterization of a temperature-sensitive lethal mutant of Salmonella thyphimurium that is conditionally defective in 3-deoxy-D-manno-octulosonate-8-phosphate synthesis
J. Bacteriol.
150
447-455
1982
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Ray, P.H.
3-Deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase
Methods Enzymol.
83
525-530
1982
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Woisetschlger, M.; Hgenauer, G.
Cloning and characterization of the gene encoding 3-deoxy-D-manno-octulosonate 8-phosphate synthetase from Escherichia coli
J. Bacteriol.
168
437-439
1986
Escherichia coli
Manually annotated by BRENDA team
Woisetschlaeger, M.; Hoedl-Neuhofer, A.; Hoegenauer, G.
Localization of the kdsA gene with the aid of the physical map of the Escherichia coli chromosome
J. Bacteriol.
170
5382-5384
1988
Escherichia coli
Manually annotated by BRENDA team
Dotson, G.D.; Nanjappan, P.; Reily, M.D.; Woodward, R.W.
Stereochemistry of 3-deoxyoctulosonate 8-phosphate synthase
Biochemistry
32
12392-12397
1993
Escherichia coli
Manually annotated by BRENDA team
Liang, P.H.; Lewis, J.; Anderson, K.S.
Catalytic mechanism of Kdo8P synthase: transient kinetic studies and evaluation of a putative reaction intermediate
Biochemistry
37
1639-16399
1998
Escherichia coli
-
Manually annotated by BRENDA team
Wylie, J.L.; Iliffe, E.R.; Wang, L.L.; McClarty, G.
Identification, characterization, and developmental regulation of Chlamydia trachomatis 3-deoxy-D-manno-octulosonate (KDO)-8-phosphate synthetase and CMP-KDO synthetase
Infect. Immun.
65
1527-1530
1997
Chlamydia trachomatis
Manually annotated by BRENDA team
Hedstrom, L.; Abeles, R.
3-Deoxy-D-manno-octulosonate-8-phosphate synthase catalyzes the C-O bond cleavage of phosphoenolpyruvate
Biochem. Biophys. Res. Commun.
157
816-820
1988
Escherichia coli
Manually annotated by BRENDA team
Tolbert, W.D.; Moll, J.R.; Bauerle, R.; Kretsinger, R.H.
Crystallization and preliminary crystallographic studies of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Escherichia coli
Proteins Struct. Funct. Genet.
24
407-408
1996
Escherichia coli
Manually annotated by BRENDA team
Dotson, G.D.; Dua, R.K.; Clemens, J.C.; Wooten, E.W.; Woodard, R.W.
Overproduction and one-step purification of Escherichia coli 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase and oxygen transfer studies during catalysis using isotopic-shifted heteronuclear NMR
J. Biol. Chem.
270
13698-13705
1995
Escherichia coli
Manually annotated by BRENDA team
Subramaniam, P.S.; Xie, G.; Xia, T.; Jensen, R.A
Substrate ambiguity of 3-deoxy-D-manno-octulosonate 8-phosphate synthase from Neisseria gonorrhoeae in the context of its membership in a protein family containing a subset of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthases
J. Bacteriol.
180
119-127
1998
Neisseria gonorrhoeae
Manually annotated by BRENDA team
Kohen, A.; Jakob, A.; Baasov, T.
Mechanistic studies of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase from Escherichia coli
Eur. J. Biochem.
208
443-449
1992
Escherichia coli
Manually annotated by BRENDA team
Baasov, T.; Sheffer-Dee-Noor, S.; Kohen, A.; Jakob, A.; Belakhov, V.
Catalytic mechanism of 3-deoxy-D-manno-octulosonate-8-phosphate synthase. The use of synthetic analogues to probe the structure of the putative reaction intermediate
Eur. J. Biochem.
217
991-999
1993
Escherichia coli
Manually annotated by BRENDA team
Brabetz, W.; Brade, H.
Molecular cloning, sequence analysis and functional characterization of the gene kdsA, encoding 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase of Chlamydia psittaci 6BC
Eur. J. Biochem.
244
66-73
1997
Chlamydia psittaci, Chlamydia psittaci 6BC
Manually annotated by BRENDA team
Doong, R.L.; Ahmad, S.; Jensen, R.A.
Higher plants express 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Plant Cell Environ.
14
113-120
1991
Acinetobacter calcoaceticus, Allium cepa, Brassica oleracea, Cucumis sativus, Daucus carota, Ipomoea batatas, Nicotiana sylvestris, no activity in Malus sp., Solanum tuberosum, Spinacia oleracea
-
Manually annotated by BRENDA team
Coutrot, P.; Dumarcay, S.; Finance, C.; Tabyaoui, M.; Grison, C.
Investigation of new potent KDO-8-phosphate synthetase inhibitors
Bioorg. Med. Chem. Lett.
9
949-952
1999
Gram-negative bacteria
Manually annotated by BRENDA team
Duewel, H.S.; Radaev, S.; Wang, J.; Woodard, R.W.; Gatti, D.L.
Substrate and metal complexes of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus at 1.9-A resolution. Implications for the condensation mechanism
J. Biol. Chem.
276
8393-8402
2001
Aquifex aeolicus
Manually annotated by BRENDA team
Radaev, S.; Dastidar, P.; Patel, M.; Woodard, R.W.; Gatti, D.L.
Structure and mechanism of 3-deoxy-D-manno-octulosonate 8-phosphate synthase
J. Biol. Chem.
275
9476-9484
2000
Escherichia coli (P0A715), Escherichia coli
Manually annotated by BRENDA team
Birck, M.R.; Woodard, R.W.
Aquifex aeolicus 3-Deoxy-D-manno-2-octulosonic acid 8-phosphate synthase: A new class of KDO 8-P synthase?
J. Mol. Evol.
52
205-214
2001
Aggregatibacter actinomycetemcomitans, Bordetella bronchiseptica, Aquifex aeolicus, Aquifex aeolicus (O66496), Arabidopsis thaliana, Porphyromonas gingivalis, Bordetella pertussis, Campylobacter jejuni, Caulobacter vibrioides, Chlorobaculum tepidum, Helicobacter pylori, Helicobacter pylori (Q9ZN55), Klebsiella pneumoniae, Pasteurella multocida, Yersinia pestis, Pisum sativum, Shewanella putrefaciens, Salmonella enterica subsp. enterica serovar Typhi, Vibrio cholerae serotype O1, Actinobacillus pleuropneumoniae (O68662), Escherichia coli (P0A715), Escherichia coli, Chlamydia trachomatis (P0CD74), Haemophilus influenzae (P45251), Mannheimia haemolytica (P95514), Chlamydia psittaci (Q46225), Neisseria meningitidis (Q9XAZ3), Neisseria gonorrhoeae (Q9XB02), Chlamydia pneumoniae (Q9Z7I4), Rickettsia prowazekii (Q9ZE84), Pseudomonas aeruginosa (Q9ZFK4)
Manually annotated by BRENDA team
Asojo, O.; Friedman, J.; Adir, N.; Belokhov, V.; Shonam, Y.; Baasov, T.
Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor
Biochemistry
40
6326-6334
2001
Escherichia coli (P0A715), Escherichia coli
Manually annotated by BRENDA team
Krosky, D.J.; Alm, R.; Berg, M.; Carmel, G.; Tummino, P.J.; Xu, B.; Yang, W.
Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase is a zinc-metalloenzyme
Biochim. Biophys. Acta
1594
297-306
2002
Escherichia coli, Helicobacter pylori
Manually annotated by BRENDA team
Wang, J.; Duewel, H.S.; Stuckey, J.A.; Woodard, R.W.; Gatti, D.L.
Function of His185 in Aquifex aeolicus 3-deoxy-D-manno-octulosonate 8-phosphate synthase
J. Mol. Biol.
324
205-214
2002
Aquifex aeolicus (O66496), Aquifex aeolicus
Manually annotated by BRENDA team
Sheflyan, G.Y.; Sundaram, A.K.; Taylor, W.P.; Woodard, R.W.
Substrate ambiguity of 3-deoxy-D-manno-octulosonate 8-phosphate synthase from Neisseria gonorrhoeae revisited
J. Bacteriol.
182
5005-5008
2000
Neisseria gonorrhoeae
Manually annotated by BRENDA team
Taylor, W.P.; Sheflyan, G.Y.; Woodard, R.W.
A single point mutation in 3-deoxy-D-manno-octulosonate-8-phosphate synthase is responsible for temperature sensitivity in a mutant strain of Salmonella typhimurium
J. Biol. Chem.
275
32141-32146
2000
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Duewel, H.S.; Sheflyan, G.Y.; Woodard, R.W.
Functional and biochemical characterization of a recombinant 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase from the hyperthermophilic bacterium Aquifex aeolicus
Biochem. Biophys. Res. Commun.
263
346-351
1999
Aquifex aeolicus
Manually annotated by BRENDA team
Howe, D.L.; Sundaram, A.K.; Wu, J.; Gatti, D.L.; Woodard, R.W.
Mechanistic insight into 3-deoxy-D-manno-octulosonate-8-phosphate synthase and 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase utilizing phosphorylated monosaccharide analogues
Biochemistry
42
4843-4854
2003
Escherichia coli
Manually annotated by BRENDA team
Duewel, H.S.; Woodard, R.W.
A metal bridge between two enzyme families. 3-Deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus requires a divalent metal for activity
J. Biol. Chem.
275
22824-22831
2000
Aquifex aeolicus
Manually annotated by BRENDA team
Wu, J.; Patel, M.A.; Sundaram, A.K.; Woodard, R.W.
Functional and biochemical characterization of a recombinant Arabidopsis thaliana 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Biochem. J.
381
185-193
2004
Arabidopsis thaliana
Manually annotated by BRENDA team
Xu, X.; Kona, F.; Wang, J.; Lu, J.; Stemmler, T.; Gatti, D.L.
The catalytic and conformational cycle of Aquifex aeolicus KDO8P synthase: role of the L7 loop
Biochemistry
44
12434-12444
2005
Aquifex aeolicus (O66496), Aquifex aeolicus
Manually annotated by BRENDA team
Shulami, S.; Yaniv, O.; Rabkin, E.; Shoham, Y.; Baasov, T.
Cloning, expression, and biochemical characterization of 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) synthase from the hyperthermophilic bacterium Aquifex pyrophilus
Extremophiles
7
471-481
2003
Aquifex pyrophilus
Manually annotated by BRENDA team
Sau, A.K.; Li, Z.; Anderson, K.S.
Probing the role of metal ions in the catalysis of Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate synthase using a transient kinetic analysis
J. Biol. Chem.
279
15787-15794
2004
Helicobacter pylori
Manually annotated by BRENDA team
Shulami, S.; Furdui, C.; Adir, N.; Shoham, Y.; Anderson, K.S.; Baasov, T.
A reciprocal single mutation affects the metal requirement of 3-deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) synthases from Aquifex pyrophilus and Escherichia coli
J. Biol. Chem.
279
45110-45120
2004
Escherichia coli (P0A715), Escherichia coli, Aquifex pyrophilus (Q8GLK7), Aquifex pyrophilus
Manually annotated by BRENDA team
Matsuura, K.; Miyagawa, I.; Kobayashi, M.; Ohta, D.; Matoh, T.
Arabidopsis 3-deoxy-D-manno-oct-2-ulosonate-8-phosphate synthase: cDNA cloning and expression analyses
J. Exp. Bot.
54
1785-1787
2003
Arabidopsis sp., Arabidopsis thaliana (Q9AV97), Arabidopsis sp. AtkdsA2
Manually annotated by BRENDA team
Vainer, R.; Belakhov, V.; Rabkin, E.; Baasov, T.; Adir, N.
Crystal structures of Escherichia coli KDO8P synthase complexes reveal the source of catalytic irreversibility
J. Mol. Biol.
351
641-652
2005
Escherichia coli (P0A715), Escherichia coli
Manually annotated by BRENDA team
Delmas, F.; Petit, J.; Joubes, J.; Seveno, M.; Paccalet, T.; Hernould, M.; Lerouge, P.; Mouras, A.; Chevalier, C.
The gene expression and enzyme activity of plant 3-deoxy-D-manno-2-octulosonic acid-8-phosphate synthase are preferentially associated with cell division in a cell cycle-dependent manner
Plant Physiol.
133
348-360
2003
Nicotiana tabacum (Q7XZC8), Nicotiana tabacum, Solanum lycopersicum (Q9ARD1), Solanum lycopersicum
Manually annotated by BRENDA team
Li, Z.; Sau, A.K.; Furdui, C.M.; Anderson, K.S.
Probing the role of tightly bound phosphoenolpyruvate in Escherichia coli 3-deoxy-d-manno-octulosonate 8-phosphate synthase catalysis using quantitative time-resolved electrospray ionization mass spectrometry in the millisecond time range
Anal. Biochem.
343
35-47
2005
Escherichia coli
Manually annotated by BRENDA team
Kona, F.; Xu, X.; Martin, P.; Kuzmic, P.; Gatti, D.L.
Structural and mechanistic changes along an engineered path from metallo to nonmetallo 3-deoxy-D-manno-octulosonate 8-phosphate synthases
Biochemistry
46
4532-4544
2007
Aquifex aeolicus (O66496), Aquifex aeolicus
Manually annotated by BRENDA team
Ahn, M.; Cochrane, F.C.; Patchett, M.L.; Parker, E.J.
Arabinose 5-phosphate analogues as mechanistic probes for Neisseria meningitidis 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Bioorg. Med. Chem.
16
9830-9836
2008
Neisseria meningitidis (Q9JZ55), Neisseria meningitidis
Manually annotated by BRENDA team
Delmas, F.; Seveno, M.; Northey, J.G.; Hernould, M.; Lerouge, P.; McCourt, P.; Chevalier, C.
The synthesis of the rhamnogalacturonan II component 3-deoxy-D-manno-2-octulosonic acid (Kdo) is required for pollen tube growth and elongation
J. Exp. Bot.
59
2639-2647
2008
Arabidopsis thaliana (Q9AV97)
Manually annotated by BRENDA team
Kona, F.; Tao, P.; Martin, P.; Xu, X.; Gatti, D.L.
Electronic structure of the metal center in the Cd(2+), Zn(2+), and Cu(2+) substituted forms of KDO8P synthase: implications for catalysis
Biochemistry
48
3610-3630
2009
Aquifex aeolicus (O66496), Aquifex aeolicus
Manually annotated by BRENDA team
Li, Z.; Sau, A.
Probing the subunit-subunit interaction of the tetramer of E. coli KDO8P synthase by electrospray ionization mass spectrometry
Chin. J. Chem.
27
111-116
2009
Escherichia coli (P0A715)
-
Manually annotated by BRENDA team
Cochrane, F.C.; Cookson, T.V.; Jameson, G.B.; Parker, E.J.
Reversing evolution: re-establishing obligate metal ion dependence in a metal-independent KDO8P synthase
J. Mol. Biol.
390
646-661
2009
Neisseria meningitidis (Q9JZ55), Neisseria meningitidis
Manually annotated by BRENDA team
Li, Z.; Sau, A.K.
Structural studies on Helicobacter pylori 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase using electrospray ionization mass spectrometry: a tetrameric complex composed of dimeric dimers
Rapid Commun. Mass Spectrom.
23
1573-1578
2009
Helicobacter pylori
Manually annotated by BRENDA team
Allison, T.M.; Hutton, R.D.; Cochrane, F.C.; Yeoman, J.A.; Jameson, G.B.; Parker, E.J.
Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Biochemistry
50
3686-3695
2011
Acidithiobacillus ferrooxidans, Neisseria meningitidis
Manually annotated by BRENDA team
Allison, T.M.; Yeoman, J.A.; Hutton, R.D.; Cochrane, F.C.; Jameson, G.B.; Parker, E.J.
Specificity and mutational analysis of the metal-dependent 3-deoxy-D-manno-octulosonate 8-phosphate synthase from Acidithiobacillus ferrooxidans
Biochim. Biophys. Acta
1804
1526-1536
2010
Acidithiobacillus ferrooxidans
Manually annotated by BRENDA team
Harrison, A.N.; Reichau, S.; Parker, E.J.
Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-d-manno-octulosonate 8-phosphate synthase
Bioorg. Med. Chem. Lett.
22
907-911
2012
Acidithiobacillus ferrooxidans, Neisseria meningitidis
Manually annotated by BRENDA team
Tao, P.; Schlegel, H.B.; Gatti, D.L.
Common basis for the mechanism of metallo and non-metallo KDO8P synthases
J. Inorg. Biochem.
104
1267-1275
2010
synthetic construct
Manually annotated by BRENDA team
Nelson, S.K.; Kelleher, A.; Robinson, G.; Reiling, S.; Asojo, O.A.
Structure of 2-keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase from Pseudomonas aeruginosa
Acta Crystallogr. Sect. F
69
1084-1088
2013
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Allison, T.M.; Cochrane, F.C.; Jameson, G.B.; Parker, E.J.
Examining the role of intersubunit contacts in catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Biochemistry
52
4676-4686
2013
Neisseria meningitidis
Manually annotated by BRENDA team
Wen, L.; Zheng, Y.; Li, T.; Wang, P.G.
Enzymatic synthesis of 3-deoxy-D-manno-octulosonic acid (KDO) and its application for LPS assembly
Bioorg. Med. Chem. Lett.
26
2825-2828
2016
Escherichia coli
Manually annotated by BRENDA team
Smyth, K.M.; Marchant, A.
Conservation of the 2-keto-3-deoxymanno-octulosonic acid (Kdo) biosynthesis pathway between plants and bacteria
Carbohydr. Res.
380
70-75
2013
Escherichia coli, Arabidopsis thaliana (Q6NQL4), Arabidopsis thaliana (Q9AV97)
Manually annotated by BRENDA team
Cho, S.; Im, H.; Lee, K.Y.; Chen, J.; Kang, H.J.; Yoon, H.J.; Min, K.H.; Lee, K.R.; Park, H.J.; Lee, B.J.
Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-D-manno-octulosonate 8-phosphate synthase (HpKDO8PS)
Eur. J. Med. Chem.
108
188-202
2016
Helicobacter pylori (P56060), Helicobacter pylori
Manually annotated by BRENDA team
Zhang, F.; Xu, Y.; Zhang, Z.
Heterologous expression, purification, crystallization and preliminary X-ray diffraction analysis of KDO8P synthase from Arabidopsis thaliana
Protein Expr. Purif.
101
133-137
2014
Arabidopsis thaliana (Q6NQL4), Arabidopsis thaliana (Q9AV97), Arabidopsis thaliana
Manually annotated by BRENDA team
Gama, S.R.; Balachandran, N.; Berti, P.J.
Campylobacter jejuni KDO8P Synthase, its inhibition by KDO8P oxime, and control of the residence time of slow-binding inhibition
Biochemistry
57
5327-5338
2018
Campylobacter jejuni
Manually annotated by BRENDA team
Araujo, J.O.; Dos Santos, A.M.; Lameira, J.; Alves, C.N.; Lima, A.H.
Computational Investigation of bisphosphate inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Molecules
24
2370
2019
Neisseria meningitidis serogroup B (Q9JZ55), Neisseria meningitidis serogroup B MC58 (Q9JZ55)
Manually annotated by BRENDA team
Zhu, F.; Zhang, F.; Zhang, Z.; Wu, L.
Expression, purification and characterization of 3-deoxy-D-manno-octulosonate 8-phosphate synthase from Phyllostachys edulis
Sheng Wu Gong Cheng Xue Bao
33
1989-1998
2017
Phyllostachys edulis
Manually annotated by BRENDA team