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2 O-acetyl-L-homoserine + dimethyldisulfide
2 L-methionine + 2 acetate
-
dimethyldisulfide may be reductively cleaved into methanethiol prior to assimilation
-
-
?
2 O-acetyl-L-homoserine + H2S
2 L-homocysteine + 2 acetate
-
-
-
-
?
L-homocysteine + KCN
gamma-cyano-alpha-aminobutyric acid + H2S
L-homoserine + H2S
homocysteine + ?
L-homoserine + H2S
L-homocysteine + H2O
L-homoserine + KCN
?
-
inactive
-
-
?
L-serine + H2S
L-cysteine + H2O
L-serine + KCN
?
-
inactive
-
-
?
L-serine-O-sulfate + Na2Se
?
-
-
-
-
?
L-serine-O-sulfate + NaHSe
?
-
-
-
-
?
L-serine-O-sulfate + Se2-
L-selenocystine + ?
-
-
-
-
?
O-acetyl-L-homoserine + 2-mercaptoethanol
?
o-acetyl-L-homoserine + CN-
gamma-cyano-alpha-aminobutyric acid + acetate
O-acetyl-L-homoserine + ethanol
O-ethyl-homoserine + acetic acid
O-acetyl-L-homoserine + ethyl mercaptan
L-ethionine + acetic acid
o-acetyl-L-homoserine + H2S
L-homocysteine + acetate
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
O-acetyl-L-homoserine + hydrogen sulfide
L-homocysteine + acetate
o-acetyl-L-homoserine + KCN
gamma-cyano-alpha-aminobutyric acid + acetate
-
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
O-acetyl-L-homoserine + methanethiol
L-methionine + acetic acid
O-acetyl-L-homoserine + methanol
O-methyl-homoserine + acetic acid
Corynebacterium acetophilum
-
-
-
?
O-acetyl-L-homoserine + methyl mercaptan
L-methionine + acetic acid
O-acetyl-L-homoserine + methylselenide
seleno-L-methionine + acetic acid
O-acetyl-L-homoserine + n-butanol
O-butyl-homoserine + acetic acid
O-acetyl-L-homoserine + n-pentanol
O-pentyl-homoserine + acetic acid
Corynebacterium acetophilum
-
-
-
?
O-acetyl-L-homoserine + n-propanol
O-propyl-homoserine + acetic acid
O-acetyl-L-homoserine + S2-
L-homocysteine + acetic acid
-
physiological substrate NaHS
-
-
?
O-acetyl-L-homoserine + Se2-
L-selenohomocystine + ?
-
-
-
-
?
O-acetyl-L-homoserine + thioglycerol
?
O-acetyl-L-homoserine + thioglycolic acid
?
O-acetyl-L-serine
L-cysteine + acetate
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
O-acetyl-L-serine + H2S
S-methylcysteine + ?
-
-
-
?
o-acetyl-L-serine + KCN
?
-
inactive
-
-
?
O-acetyl-L-serine + methanethiol
?
-
reaction only in phosphate buffer, relative activity compared to O-acetyl-L-homoserine 14.8%
-
-
?
O-acetyl-L-serine + methyl mercaptan
S-methylcysteine + ?
-
-
-
?
O-acetyl-L-serine + NaHSe2
L-selenocystine + ?
-
-
-
-
?
O-acetyl-L-serine + S2-
L-cysteine + acetic acid
-
physiological substrate NaHS
-
-
?
O-acetyl-L-serine + Se2-
L-selenocystine + ?
-
-
-
-
?
O-phospho-L-serine + H2S
?
o-phospho-L-serine + KCN
?
-
inactive
-
-
?
O-phosphoryl-L-serine + H2S
L-cysteine + H2O
Q76K51
lesser activity
-
-
?
O-succinyl-L-homoserine + H2S
homocysteine + ?
O-succinyl-L-homoserine + H2S
L-homocysteine + succinate
o-succinyl-L-homoserine + KCN
?
-
inactive
-
-
?
additional information
?
-
L-cysteine + KCN
?
-
inactive
-
-
?
L-cysteine + KCN
?
-
inactive
-
-
?
L-glutamic acid + KCN
?
-
inactive
-
-
?
L-glutamic acid + KCN
?
-
inactive
-
-
?
L-glutamine + KCN
?
-
inactive
-
-
?
L-glutamine + KCN
?
-
inactive
-
-
?
L-homocysteine + KCN
gamma-cyano-alpha-aminobutyric acid + H2S
-
-
-
-
?
L-homocysteine + KCN
gamma-cyano-alpha-aminobutyric acid + H2S
-
-
-
-
?
L-homoserine + H2S
homocysteine + ?
-
-
-
-
?
L-homoserine + H2S
homocysteine + ?
Q93I77
-
-
-
?
L-homoserine + H2S
homocysteine + ?
Q93I77
-
-
-
?
L-homoserine + H2S
L-homocysteine + H2O
Q76K51
lesser activity
-
-
?
L-homoserine + H2S
L-homocysteine + H2O
Q76K51
lesser activity
-
-
?
L-serine + H2S
L-cysteine + H2O
Q76K51
lesser activity
-
-
?
L-serine + H2S
L-cysteine + H2O
Q76K51
lesser activity
-
-
?
O-acetyl-L-homoserine + 2-mercaptoethanol
?
-
-
-
-
?
O-acetyl-L-homoserine + 2-mercaptoethanol
?
-
-
-
-
?
o-acetyl-L-homoserine + CN-
gamma-cyano-alpha-aminobutyric acid + acetate
-
glutamine and glutamic acid synthesis pathway
-
-
?
o-acetyl-L-homoserine + CN-
gamma-cyano-alpha-aminobutyric acid + acetate
-
glutamine and glutamic acid synthesis pathway
-
-
?
O-acetyl-L-homoserine + ethanol
O-ethyl-homoserine + acetic acid
Corynebacterium acetophilum
-
-
-
?
O-acetyl-L-homoserine + ethanol
O-ethyl-homoserine + acetic acid
Corynebacterium acetophilum A51
-
-
-
?
O-acetyl-L-homoserine + ethyl mercaptan
L-ethionine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + ethyl mercaptan
L-ethionine + acetic acid
-
-
-
?
o-acetyl-L-homoserine + H2S
L-homocysteine + acetate
AY257545
-
-
-
?
o-acetyl-L-homoserine + H2S
L-homocysteine + acetate
AY257545
-
-
-
?
o-acetyl-L-homoserine + H2S
L-homocysteine + acetate
Q76K51
-
-
-
?
o-acetyl-L-homoserine + H2S
L-homocysteine + acetate
Q76K51
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
Corynebacterium acetophilum
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
direct sulfhydrylation pathway, methionine biosynthesis
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
direct sulfhydrylation pathway, biosynthesis of homocysteine
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
direct sulfhydrylation pathway, biosynthesis of homocysteine
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + hydrogen sulfide
L-homocysteine + acetate
-
-
-
?
O-acetyl-L-homoserine + hydrogen sulfide
L-homocysteine + acetate
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
methionine biosynthesis pathway
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
pathway for formation of methionine, incorporation of sulfur, possible temporary function for this enzyme may be formation of methionine from methylmercaptan at times of exhaustion of an exogenous source of sulfur
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
methionine biosynthetic pathway
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetic acid
-
relative activity 100%
-
?
O-acetyl-L-homoserine + methyl mercaptan
L-methionine + acetic acid
Corynebacterium acetophilum
-
-
-
?
O-acetyl-L-homoserine + methyl mercaptan
L-methionine + acetic acid
Corynebacterium acetophilum A51
-
-
-
?
O-acetyl-L-homoserine + methyl mercaptan
L-methionine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + methyl mercaptan
L-methionine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + methyl mercaptan
L-methionine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + methyl mercaptan
L-methionine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + methyl mercaptan
L-methionine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + methyl mercaptan
L-methionine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + methylselenide
seleno-L-methionine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + methylselenide
seleno-L-methionine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + n-butanol
O-butyl-homoserine + acetic acid
Corynebacterium acetophilum
-
-
-
?
O-acetyl-L-homoserine + n-butanol
O-butyl-homoserine + acetic acid
Corynebacterium acetophilum A51
-
-
-
?
O-acetyl-L-homoserine + n-propanol
O-propyl-homoserine + acetic acid
Corynebacterium acetophilum
-
-
-
?
O-acetyl-L-homoserine + n-propanol
O-propyl-homoserine + acetic acid
Corynebacterium acetophilum A51
-
-
-
?
O-acetyl-L-homoserine + thioglycerol
?
-
-
-
-
?
O-acetyl-L-homoserine + thioglycerol
?
-
-
-
-
?
O-acetyl-L-homoserine + thioglycolic acid
?
-
-
-
-
?
O-acetyl-L-homoserine + thioglycolic acid
?
-
-
-
-
?
O-acetyl-L-serine
L-cysteine + acetate
-
-
-
-
?
O-acetyl-L-serine
L-cysteine + acetate
-
-
-
-
?
O-acetyl-L-serine
L-cysteine + acetate
Q76K51
lesser activity
-
-
?
O-acetyl-L-serine
L-cysteine + acetate
Q76K51
lesser activity
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
-
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
-
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
-
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
-
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
Corynebacterium acetophilum
-
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
-
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
-
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
-
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
Q93I77
-
-
?
O-acetyl-L-serine + H2S
L-cysteine + acetic acid
Q93I77
-
-
?
O-phospho-L-serine + H2S
?
Q93I77
-
-
-
?
O-phospho-L-serine + H2S
?
Q93I77
-
-
-
?
O-succinyl-L-homoserine + H2S
homocysteine + ?
-
-
-
-
?
O-succinyl-L-homoserine + H2S
homocysteine + ?
Q93I77
-
-
-
?
O-succinyl-L-homoserine + H2S
homocysteine + ?
Q93I77
-
-
-
?
O-succinyl-L-homoserine + H2S
L-homocysteine + succinate
Q76K51
lesser activity
-
-
?
O-succinyl-L-homoserine + H2S
L-homocysteine + succinate
Q76K51
lesser activity
-
-
?
additional information
?
-
Corynebacterium acetophilum
-
O-acetyl-L-serine, L-homoserine, O-succinyl-L-homoserine and O-acetyl-L-threonine are no substrates
-
-
?
additional information
?
-
Corynebacterium acetophilum A51
-
O-acetyl-L-serine, L-homoserine, O-succinyl-L-homoserine and O-acetyl-L-threonine are no substrates
-
-
?
additional information
?
-
-
no cystathione formed from cysteine, no alpha-ketobutyrate formed from O-acetylhomoserine, negligible activity with homoserine and serine, O-succinylhomoserine, O-phosphorylhomoserine, O-acetylserine and O-phosphorylserine are no substrates
-
-
?
additional information
?
-
-
L-homoserine, O-succinyl-DL-homoserine, O-phosphoryl-L-homoserine, L-serine, O-acetyl-L-serine, O-phosphoryl-L-serine react at less than 1% the rate with O-acetyl-L-homoserine
-
-
?
additional information
?
-
-
L-homoserine and O-succinyl-L-homoserine are no substrates
-
-
?
additional information
?
-
-
L-homoserine and O-succinyl-L-homoserine are no substrates
-
-
?
additional information
?
-
-
O-acetyl-L-threonine, O-acetyl-L-tyrosine, O-acetyl-L-hydroxyproline and O-succinyl-DL-homoserine are no substrates
-
-
?
additional information
?
-
-
O-acetyl-L-threonine, O-acetyl-L-tyrosine, O-acetyl-L-hydroxyproline and O-succinyl-DL-homoserine are no substrates
-
-
?
additional information
?
-
-
cystathionine is not synthesized from O-acetylhomoserine and cysteine, O-acetyl-L-serine is no substrate
-
-
?
additional information
?
-
-
the enzyme sulfhydrylates both O-acetyl-L-homoserine and O-acetylserine using sulfide to yield homocysteine and cysteine, respectively
-
-
?
additional information
?
-
-
does not synthesize cystathionine from O-acetyl-L-homoserine and L-cysteine, cannot utilize cysteine as co-substrate in place of H2S, O-acetyl-L-serine, O-acetyl-L-tyrosine, O-acetyl-L-threonine, O-phospho-DL-threonine, O-phospho-L-serine, L-serine-O-sulfate and O-acetyl-L-hydroxyproline are no substrates
-
-
?
additional information
?
-
Q93I77
low cystathione beta-lyase reaction, relative activity 0.12%, no cystathione gamma-lyase reaction
-
-
?
additional information
?
-
-
low cystathione beta-lyase reaction, relative activity 0.12%, no cystathione gamma-lyase reaction
-
-
?
additional information
?
-
Q93I77
low cystathione beta-lyase reaction, relative activity 0.12%, no cystathione gamma-lyase reaction
-
-
?
additional information
?
-
-
shows with O-acetylserine 1% of the activity with O-acetylhomoserine, no activity with O-succinyl-L-homoserine, homoserine or serine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
o-acetyl-L-homoserine + CN-
gamma-cyano-alpha-aminobutyric acid + acetate
o-acetyl-L-homoserine + H2S
L-homocysteine + acetate
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
O-acetyl-L-homoserine + S2-
L-homocysteine + acetic acid
-
physiological substrate NaHS
-
-
?
O-acetyl-L-serine + S2-
L-cysteine + acetic acid
-
physiological substrate NaHS
-
-
?
o-acetyl-L-homoserine + CN-
gamma-cyano-alpha-aminobutyric acid + acetate
-
glutamine and glutamic acid synthesis pathway
-
-
?
o-acetyl-L-homoserine + CN-
gamma-cyano-alpha-aminobutyric acid + acetate
-
glutamine and glutamic acid synthesis pathway
-
-
?
o-acetyl-L-homoserine + H2S
L-homocysteine + acetate
AY257545
-
-
-
?
o-acetyl-L-homoserine + H2S
L-homocysteine + acetate
AY257545
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
Corynebacterium acetophilum
-
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
direct sulfhydrylation pathway, methionine biosynthesis
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
direct sulfhydrylation pathway, biosynthesis of homocysteine
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
direct sulfhydrylation pathway, biosynthesis of homocysteine
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + H2S
L-homocysteine + acetic acid
-
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
methionine biosynthesis pathway
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
pathway for formation of methionine, incorporation of sulfur, possible temporary function for this enzyme may be formation of methionine from methylmercaptan at times of exhaustion of an exogenous source of sulfur
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
-
-
-
?
O-acetyl-L-homoserine + methanethiol
L-methionine + acetate
-
methionine biosynthetic pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
butanol
Corynebacterium acetophilum
-
-
diethyl N-[[3-bromo-4-([[2,4-diamino-5-(2,3-dibromopropyl)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl]amino)phenyl]carbonyl]glutamate
-
inhibition of methionine synthase, arrest of cell cycle in G1/S phase and apoptosis. Treatment results in increase in cyclin E and cyclin-dependent kinase 2, reduction of caspase-3, poly(ADP-ribose) polymerase, caspase-8, and caspase-9 protein levels
DL-propargylglycine
Q76K51
89% inhibition at 1 mM
hydrazine
Corynebacterium acetophilum
-
-
hydroxylamine
Q76K51
95% inhibition at 1 mM, 76% at 0.1 mM
Hydroxylamine hydrochloride
Isopropanol
Corynebacterium acetophilum
-
-
L-propargylglycine
irreversible, rapid inactivation; suicide inhibitor
methanol
Corynebacterium acetophilum
-
-
methylmercaptan
Corynebacterium acetophilum
-
-
n-Propanol
Corynebacterium acetophilum
-
-
N-[[3-bromo-4-([[2,4-diamino-5-(2,3-dibromopropyl)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl]amino)phenyl]carbonyl]glutamic acid
-
inhibition of methionine synthase, arrest of cell cycle in G1/S phase and apoptosis. Treatment results in increase in cyclin E and cyclin-dependent kinase 2, reduction of caspase-3, poly(ADP-ribose) polymerase, caspase-8, and caspase-9 protein levels
Na2S
Corynebacterium acetophilum
-
-
Ngamma-acetyl-L-2,4-diaminobutyric acid
competitive; competitive and reversible inhibition
O-acetyl-L-threonine
Corynebacterium acetophilum
-
-
O-ethylhomoserine
Corynebacterium acetophilum
-
-
p-chloromercuribenzoate
Corynebacterium acetophilum
-
-
pyridoxal
-
inhibits the activity competitively with respect to pyridoxal 5'-phosphate
S-adenosyl-L-homocysteine
DL-C-propagylglycine
-
only 25% inhibition
DL-C-propagylglycine
Q93I77
-
Hydroxylamine hydrochloride
-
-
Hydroxylamine hydrochloride
Corynebacterium acetophilum
-
-
Hydroxylamine hydrochloride
-
-
Hydroxylamine hydrochloride
-
-
Hydroxylamine hydrochloride
Q93I77
-
KCN
Corynebacterium acetophilum
-
-
L-homoserine
Corynebacterium acetophilum
-
-
L-homoserine
-
competitive inhibition
L-methionine
-
only 20% inhibition
L-methionine
product inhibition
L-methionine
-
10 mM, residual activity is 13%
L-methionine
-
competitive inhibition
L-methionine
-
competitive inhibition
L-methionine
-
competitive inhibition
L-methionine
Q76K51
68% inhibition at 1 mM
L-Penicillamine
-
-
O-acetyl-L-serine
Corynebacterium acetophilum
-
-
O-acetyl-L-serine
-
competitive inhibition
O-succinyl-DL-homoserine
Corynebacterium acetophilum
-
-
O-succinyl-DL-homoserine
-
competitive inhibition
phenylhydrazine
-
-
phenylhydrazine
Corynebacterium acetophilum
-
-
phenylhydrazine
Q76K51
95% inhibition at 10 mM, 12% at 1 mM
S-adenosyl-L-homocysteine
-
-
S-adenosyl-L-homocysteine
-
-
S-adenosyl-L-methionine
-
-
S-adenosyl-L-methionine
-
-
S-adenosyl-L-methionine
-
-
Semicarbazide
-
-
Semicarbazide
Q76K51
76% inhibition at 10 mM, 12% at 1 mM
additional information
-
no sulfhydryl reagents inhibits the enzyme, S-adenosylmethionine is no inhibitor
-
additional information
-
no repression by S-adenosyl-L-methionine
-
additional information
-
no end product inhibition by methionine or S-adenosylmethionine observed
-
additional information
-
L-serine, glycine and L-alanine are not inhibitors, dithiothreitol and p-chloromercuribenzoate shows no inhibitory effect
-
additional information
-
p-chloromercuribenzoic acid, 5,5'-dithio-bis(2-nitrobenzoic acid) and monoiodoacetic acid have no inhibitory effect
-
additional information
-
L-serine, glycine, cystathione and S-adenosyl-L-methionine are no inhibitors
-
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brenda
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96
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Schizosaccharomyces pombe
brenda
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Synthesis of selenocystine and selenohomocystine with O-acetylhomoserine sulfhydrylase
Agric. Biol. Chem.
49
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1985
Saccharomyces cerevisiae
-
brenda
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Purification and properties of O-acetyl-L-homoserine O-sulfhydrylase from Aspergillus nidulans
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36
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-
brenda
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Comparative studies on O-acetylhomoserine sulfhydrylase: physiological role and characterization of the Aspergillus nidulans enzyme
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40
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Aspergillus nidulans, Aspergillus nidulans sG8
brenda
Yamagata, S.; Isaji, M.; Nakamura, K.; Fujisaki, S.; Doi, K.; Bawden, S.; D'Andrea, R.
Overexpression of the Saccharomyces cerevisiae MET17/MET25 gene in Escherichia coli and comparative characterization of the product with O-acetylserine-O-acetylhomoserine sulfhydrylase of the yeast
Appl. Microbiol. Biotechnol.
42
92-99
1994
Saccharomyces cerevisiae
brenda
Shimizu, H.; Yamagata, S.; Masui, R.; Inoue,Y.; Shibata, T.; Yokoyama, S.; Kuramitsu, S.; Iwama, T.
Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product
Biochim. Biophys. Acta
1549
61-72
2001
Thermus thermophilus (Q93I77), Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q93I77)
brenda
Lambert, B.D.; Titgemeyer, E.C.; Stokka, G.L.; DeBey, B.M.; Loest, C.A.
Methionine supply to growing steers affects hepatic activities of methionine synthase and betaine-homocysteine methyltransferase, but not cystathionine synthase
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132
2004-2009
2002
Bos taurus
brenda
Hacham, Y.; Gophna, U.; Amir, R.
In vivo analysis of various substrates utilized by cystathionine gamma-synthase and O-acetylhomoserine sulfhydrylase in methionine biosynthesis
Mol. Biol. Evol.
20
1513-1520
2003
Saccharomyces cerevisiae (P06106), Leptospira meyeri (P94890), Leptospira meyeri
brenda
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Comparative characterization of the oah2 gene homologous to the oah1 of Thermus thermophilus HB8
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68
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2004
Thermus thermophilus (Q76K51), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q76K51)
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Cloning of the O-acetylhomoserine sulfhydrylase gene from the ruminal bacterium selenomonas ruminantium HD4
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48
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2004
Selenomonas ruminantium (AY257545), Selenomonas ruminantium, Selenomonas ruminantium HD4 (AY257545), Selenomonas ruminantium HD4
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Purification, characterization and gene cloning of thermostable o-acetyl-L-homoserine sulfhydrylase forming gamma-cyano-alpha-aminobutyric acid
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96
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2003
Geobacillus stearothermophilus, Geobacillus stearothermophilus CN3
brenda
Yeom, H.J.; Hwang, B.J.; Lee, M.S.; Kim, Y.; Lee, H.S.
Regulation of enzymes involved in methionine biosynthesis in Corynebacterium glutamicum
J. Microbiol. Biotechnol.
14
373-378
2004
Corynebacterium glutamicum
-
brenda
Matityahu, I.; Kachan, L.; Bar Ilan, I.; Amir, R.
Transgenic tobacco plants overexpressing the Met25 gene of Saccharomyces cerevisiae exhibit enhanced levels of cysteine and glutathione and increased tolerance to oxidative stress
Amino Acids
30
185-194
2006
Saccharomyces cerevisiae
brenda
Tang, C.; Zhang, Z.; Xu, B.; Li, M.; Liu, J.; Cui, J.
Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro
Anticancer Drugs
19
697-704
2008
Homo sapiens
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Ott, N.; Geddert, H.; Sarbia, M.
Polymorphisms in methionine synthase (A2756G) and cystathionine beta-synthase (844ins68) and susceptibility to carcinomas of the upper gastrointestinal tract
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2008
Homo sapiens
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Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk
Leuk. Res.
32
401-405
2008
Homo sapiens
brenda
Tran, T.H.; Krishnamoorthy, K.; Begley, T.P.; Ealick, S.E.
A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes
Acta Crystallogr. Sect. D
67
831-838
2011
Wolinella succinogenes (Q7M844), Wolinella succinogenes
brenda
Yin, J.; Garen, C.R.; Bateman, K.; Yu, M.; Lyon, E.Z.; Habel, J.; Kim, H.; Hung, L.W.; Kim, C.Y.; James, M.N.
Expression, purification and preliminary crystallographic analysis of O-acetylhomoserine sulfhydrylase from Mycobacterium tuberculosis
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67
959-963
2011
Mycobacterium tuberculosis (L7N4M1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (L7N4M1)
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Towards methionine overproduction in Corynebacterium glutamicum - methanethiol and dimethyldisulfide as reduced sulfur sources
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20
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Corynebacterium glutamicum
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Identification of O-acetylhomoserine sulfhydrylase, a putative enzyme responsible for methionine biosynthesis in Clostridioides difficile Gene cloning and biochemical characterizations
IUBMB Life
71
1815-1823
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Clostridioides difficile (Q187D4), Clostridioides difficile, Clostridioides difficile 630 (Q187D4)
brenda