Reference on EC 2.5.1.45 - homospermidine synthase (spermidine-specific)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bttcher, F.; Ober, D.; Hartmann, T.
Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation
Can. J. Chem.
72
80-85
1994
Eupatorium cannabinum
-
Ober, D.; Hartmann, T.
Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved form deoxyhypusine synthase
Proc. Natl. Acad. Sci. USA
96
14777-14782
1999
Senecio vernalis (Q9SC13)
Ober, D.; Harms, R.; Witte, L.; Hartmann, T.
Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retains all properties of deoxyhypusine synthase except binding the eIF5A precursor protein
J. Biol. Chem.
278
12805-12812
2003
Senecio vernalis
Moll, S.; Anke, S.; Kahmann, U.; Hnsch, R.; Hartmann, T.; Ober, D.
Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase
Plant Physiol.
130
47-57
2002
Senecio vernalis
Ober, D.; Harms, R.; Hartmann, T.
Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision
Phytochemistry
55
305-309
2000
Senecio vulgaris (Q9M4B0)
Bttcher, F.; Adolph, R.D.; Hartmann, T.
Homospermidine synthase, the first pathway-specific enzyme in pyrrolizidine alkaloid biosynthesis
Phytochemistry
32
679-689
1993
Eupatorium cannabinum, Eupatorium pauciflorum, Jacobaea vulgaris
-
Graser, G.; Hartmann, T.
Biosynthetic incorporation of the aminobutyl group of spermidine into pyrrolizidine alkaloids
Phytochemistry
45
1591-1595
1997
Senecio vulgaris
-
Graser, G.; Witte, L.; Robins, D.J.; Hartmann, T.
Incorporation of chirally deuterated putrescines into pyrrolizidine alkaloids: a reinvestigation
Phytochemistry
47
1017-1024
1998
Senecio vulgaris
-
Nurhayati, N.; Ober, D.
Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: Does Crotalaria possess a functional HSS that still has DHS activity?
Phytochemistry
66
1346-1357
2005
Crotalaria juncea, Phalaenopsis hybrid cultivar (Q5ZN58)
Anke, S.; Niemuller, D.; Moll, S.; Hansch, R.; Ober, D.
Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae. Evidence from differential tissue expression of homospermidine synthase
Plant Physiol.
136
4037-4047
2004
Eupatorium cannabinum, Jacobaea vulgaris
Froelich, C.; Ober, D.; Hartmann, T.
Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species
Phytochemistry
68
1026-1037
2007
Heliotropium indicum
Anke, S.; Gonde, D.; Kaltenegger, E.; Haensch, R.; Theuring, C.; Ober, D.
Pyrrolizidine alkaloid biosynthesis in phalaenopsis orchids: developmental expression of alkaloid-specific homospermidine synthase in root tips and young flower buds
Plant Physiol.
148
751-760
2008
Phalaenopsis sp.
Ober, D.; Kaltenegger, E.
Pyrrolizidine alkaloid biosynthesis, evolution of a pathway in plant secondary metabolism
Phytochemistry
70
1687-1695
2009
Senecio vernalis, Phalaenopsis sp.
Nurhayati, N.; Gonde, D.; Ober, D.
Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes
Phytochemistry
70
508-516
2009
Phalaenopsis sp.
Abdelhady, M.; Beuerle, T.; Ober, D.
Homospermidine in transgenic tobacco results in considerably reduced spermidine levels but is not converted to pyrrolizidine alkaloid precursors
Plant Mol. Biol.
71
145-155
2009
Senecio vernalis
Niemueller, D.; Reimann, A.; Ober, D.
Distinct cell-specific expression of homospermidine synthase involved in pyrrolizidine alkaloid biosynthesis in three species of the boraginales
Plant Physiol.
159
920-929
2012
Heliotropium indicum, Symphytum officinale, Cynoglossum officinale
Sievert, C.; Beuerle, T.; Hollmann, J.; Ober, D.
Single cell subtractive transcriptomics for identification of cell-specifically expressed candidate genes of pyrrolizidine alkaloid biosynthesis
Phytochemistry
117
17-24
2015
Symphytum officinale (Q5ZN55), Heliotropium indicum (Q5ZN63), Cynoglossum officinale (Q5ZN66)
Kaltenegger, E.; Eich, E.; Ober, D.
Evolution of homospermidine synthase in the convolvulaceae: a story of gene duplication, gene loss, and periods of various selection pressures
Plant Cell
25
1213-1227
2013
Ipomoea neei, Ipomoea hederifolia, Ipomoea alba, Ipomoea meyeri, Distimake quinquefolius
Irmer, S.; Podzun, N.; Langel, D.; Heidemann, F.; Kaltenegger, E.; Schemmerling, B.; Geilfus, C.M.; Zoerb, C.; Ober, D.
New aspect of plant-rhizobia interaction: alkaloid biosynthesis in Crotalaria depends on nodulation
Proc. Natl. Acad. Sci. USA
112
4164-4169
2015
Crotalaria spectabilis (A0A0E4G3W1)
Gill, G.P.; Bryant, C.J.; Fokin, M.; Huege, J.; Fraser, K.; Jones, C.; Cao, M.; Faville, M.J.
Low pyrrolizidine alkaloid levels in perennial ryegrass is associated with the absence of a homospermidine synthase gene
BMC Plant Biol.
18
56
2018
Lolium perenne (A0A2R4PB59)
Kruse, L.H.; Stegemann, T.; Sievert, C.; Ober, D.
Identification of a second site of pyrrolizidine alkaloid biosynthesis in comfrey to boost plant defense in floral stage
Plant Physiol.
174
47-55
2017
Symphytum officinale (Q5ZN55)
Kruse, L.H.; Stegemann, T.; Jensen-Kroll, J.; Engelhardt, A.; Wesseling, A.M.; Lippert, A.; Ludwig-Mueller, J.; Ober, D.
Reduction of pyrrolizidine alkaloid levels in comfrey (Symphytum officinale) hairy roots by RNAi silencing of homospermidine synthase
Planta Med.
85
1177-1186
2019
Symphytum officinale (Q5ZN55)
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