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Enzyme Nomenclature
Information on EC 2.5.1.131 - (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase
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The expected taxonomic range for this enzyme is: Methanocaldococcus jannaschii
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EC NUMBER 
COMMENTARY 
2.5.1.131
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RECOMMENDED NAME
GeneOntology No.
(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-(4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl)furan-2-yl)methanamine + diphosphate
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
methanofuran biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
[5-(aminomethyl)furan-3-yl]methyl-diphosphate:gamma-L-glutamyltyramine [5-(aminomethyl)furan-3-yl]methyltransferase
The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, participates in the biosynthesis of the methanofuran cofactor.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
enzyme catalyzes the last step in the biosynthesis of methanofuran core structure , i.e. the condensation of 5-(aminomethyl)-3-furanmethanol-diphosphate with gamma-glutamyltyramine, respectively, to form 4-[N-(gamma-L-glutamyl)-p-(beta-aminoethyl)phenoxymethyl]-(aminomethyl)furan. Condensation of the tyramine moiety with 5-(aminomethyl)-3-furanmethanol-diphosphate occurs after formation of gamma-glutamyltyramine
physiological function
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enzyme catalyzes the last step in the biosynthesis of methanofuran core structure , i.e. the condensation of 5-(aminomethyl)-3-furanmethanol-diphosphate with gamma-glutamyltyramine, respectively, to form 4-[N-(gamma-L-glutamyl)-p-(beta-aminoethyl)phenoxymethyl]-(aminomethyl)furan. Condensation of the tyramine moiety with 5-(aminomethyl)-3-furanmethanol-diphosphate occurs after formation of gamma-glutamyltyramine
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
[5-(aminomethylfuran)-3-yl]methyl phosphate + gamma-L-glutamyltyramine
(4-[4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl]furan-2-yl)methanamine + diphosphate
[5-(aminomethylfuran)-3-yl]methyl phosphate + gamma-L-glutamyltyramine
(4-[4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl]furan-2-yl)methanamine + diphosphate
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?
[5-(aminomethylfuran)-3-yl]methyl phosphate + gamma-L-glutamyltyramine
(4-[4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl]furan-2-yl)methanamine + diphosphate
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additional information
?
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no substrate: tyramine
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 2.5.1.131)
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