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Information on EC 2.5.1.131 - (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Methanocaldococcus jannaschii
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(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase
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[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-(4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl)furan-2-yl)methanamine + diphosphate
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methanofuran biosynthesis
methanofuran biosynthesis
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methanofuran biosynthesis
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[5-(aminomethyl)furan-3-yl]methyl-diphosphate:gamma-L-glutamyltyramine [5-(aminomethyl)furan-3-yl]methyltransferase
The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, participates in the biosynthesis of the methanofuran cofactor.
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MJ0840
gene name
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UniProt
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UniProt
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physiological function
enzyme catalyzes the last step in the biosynthesis of methanofuran core structure , i.e. the condensation of 5-(aminomethyl)-3-furanmethanol-diphosphate with gamma-glutamyltyramine, respectively, to form 4-[N-(gamma-L-glutamyl)-p-(beta-aminoethyl)phenoxymethyl]-(aminomethyl)furan. Condensation of the tyramine moiety with 5-(aminomethyl)-3-furanmethanol-diphosphate occurs after formation of gamma-glutamyltyramine
physiological function
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enzyme catalyzes the last step in the biosynthesis of methanofuran core structure , i.e. the condensation of 5-(aminomethyl)-3-furanmethanol-diphosphate with gamma-glutamyltyramine, respectively, to form 4-[N-(gamma-L-glutamyl)-p-(beta-aminoethyl)phenoxymethyl]-(aminomethyl)furan. Condensation of the tyramine moiety with 5-(aminomethyl)-3-furanmethanol-diphosphate occurs after formation of gamma-glutamyltyramine
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[5-(aminomethylfuran)-3-yl]methyl phosphate + gamma-L-glutamyltyramine
(4-[4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl]furan-2-yl)methanamine + diphosphate
additional information
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[5-(aminomethylfuran)-3-yl]methyl phosphate + gamma-L-glutamyltyramine
(4-[4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl]furan-2-yl)methanamine + diphosphate
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[5-(aminomethylfuran)-3-yl]methyl phosphate + gamma-L-glutamyltyramine
(4-[4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl]furan-2-yl)methanamine + diphosphate
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additional information
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no substrate: tyramine
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no substrate: tyramine
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no substrate: tyramine
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37000
x * 37000, SDS-PAGE
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x * 37000, SDS-PAGE
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x * 37000, SDS-PAGE
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expression in Escherichia coli
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MFNF_METJA
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
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37377
Swiss-Prot
MFNF_METVA
222
24655
Swiss-Prot
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Wang, Y; Xu, H; Jones, MK; White, R.H.
Identification of the final two genes functioning in methanofuran biosynthesis in Methanocaldococcus jannaschii
J. Bacteriol.
197
2850-2858
2015
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii (Q58250), Methanocaldococcus jannaschii DSM 2661 (Q58250)
brenda
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