Information on EC 2.5.1.130 - 2-carboxy-1,4-naphthoquinone phytyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.5.1.130
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RECOMMENDED NAME
GeneOntology No.
2-carboxy-1,4-naphthoquinone phytyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
phytyl diphosphate + 2-carboxy-1,4-naphthoquinone = demethylphylloquinone + diphosphate + CO2
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
phylloquinol biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
phytyl-diphosphate:2-carboxy-1,4-naphthoquinone phytyltransferase
This enzyme, found in plants and cyanobacteria, catalyses a step in the synthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme catalyses the transfer of the phytyl chain synthesized by EC 1.3.1.83, geranylgeranyl diphosphate reductase, to 2-carboxy-1,4-naphthoquinone.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
mutant plants show pale-green young leaves and white old leaves. The ABC4 mutant plants contain no phylloquinone, and only about 3% plastoquinone. Photooxidation of P700 of PSI in the mutant is not observed, and the mutant has no P700. The maximum quantum yield of photosystem II in the ABc4 mutant is much decreased, and the electron transfer from PSII to PSI does not occur. The ultrastructure of the chloroplasts is almost the same as that of the wild-type plant. However, the chloroplasts in the albino leaves of the mutant are smaller and have a lot of grana thylakoids and few stroma thylakoids. The amounts of PSI and PSII core subunits in the mutant are significantly decreased
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phytyl diphosphate + 2-carboxy-1,4-naphthoquinone
demethylphylloquinone + diphosphate + CO2
show the reaction diagram
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phytylation occurs at position 3 of the 1,4-naphthoquinone ring. The specificity of the phytyltransferase enzyme is selective with respect to the group present at ring positions 2 and 3
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Show AA Sequence (227 entries)
Please use the Sequence Search for a specific query.