Information on EC 2.5.1.120 - aminodeoxyfutalosine synthase

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The expected taxonomic range for this enzyme is: Thermus thermophilus

EC NUMBER
COMMENTARY hide
2.5.1.120
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RECOMMENDED NAME
GeneOntology No.
aminodeoxyfutalosine synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O = 6-amino-6-deoxyfutalosine + L-methionine + bicarbonate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
1,4-dihydroxy-6-naphthoate biosynthesis I
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1,4-dihydroxy-6-naphthoate biosynthesis II
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Biosynthesis of secondary metabolites
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Ubiquinone and other terpenoid-quinone biosynthesis
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1,4-dihydroxy-6-naphthoate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (bicarbonate-hydrolysing, 6-amino-6-deoxyfutalosine-forming)
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is part of the futalosine pathway for menaquinone biosynthesis
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O
6-amino-6-deoxyfutalosine + L-methionine + bicarbonate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O
6-amino-6-deoxyfutalosine + L-methionine + bicarbonate
show the reaction diagram
Q5SK48
the enzyme is part of the futalosine pathway for menaquinone biosynthesis
6-amino-6-deoxyfutalosine i.e. 3-[3-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]propanoyl]benzoate
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
the enzyme is a member of the AdoMet radical family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
[4Fe-4S] cluster
presence of the predicted [4Fe-4S] cluster. Iron and sulfide analysis yields 2.4 irons and 2.8 sulfides per monomer of MqnE, indicating incomplete reconstitution of the cluster
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cloned into the pQE-30 expression vector, and overexpressed in Escherichia coli M15 (pREP4)
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