Information on EC 2.5.1.117 - homogentisate solanesyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.5.1.117
-
RECOMMENDED NAME
GeneOntology No.
homogentisate solanesyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
show the reaction diagram
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-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
plastoquinol-9 biosynthesis I
-
-
Ubiquinone and other terpenoid-quinone biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
all-trans-nonaprenyl diphosphate:homogentisate nonaprenyltransferase
Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10-C20 prenyl diphosphates, producing main products that are not decarboxylated [2].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + homogentisate
diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
show the reaction diagram
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-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
show the reaction diagram
farnesyl diphosphate + homogentisate
diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
show the reaction diagram
geranyl diphosphate + homogentisate
diphosphate + (3-geranyl-2,5-dihydroxyphenyl)acetate
show the reaction diagram
geranylgeranyl diphosphate + homogentisate
diphosphate + (3-geranylgeranyl-2,5-dihydroxyphenyl)acetate
show the reaction diagram
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
haloxydine
[2-((R)-1-phenyl-ethylamino)-1-phosphono-ethyl]-phosphonic acid
-
structural analogue and inhibitory mimic of farnesyl diphosphate
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025
(2E,6E)-farnesyl diphosphate
-
pH 8.5, 28°C
0.04
homogentisate
-
pH 8.5, 28°C
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.038
haloxydine
-
pH 8.5, 28°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
chloroplast envelope
Manually annotated by BRENDA team
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli