Information on EC 2.5.1.102 - geranyl-pyrophosphate-olivetolic acid geranyltransferase

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The expected taxonomic range for this enzyme is: Cannabis sativa

EC NUMBER
COMMENTARY hide
2.5.1.102
-
RECOMMENDED NAME
GeneOntology No.
geranyl-pyrophosphate-olivetolic acid geranyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate = diphosphate + cannabigerolate
show the reaction diagram
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-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
cannabinoid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
geranyl-diphosphate:olivetolate geranyltransferase
Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
var. Skunk
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
-
GOT is the first enzyme in the biosynthesis of DELTA1-tetrahydrocannabinolic acid and cannabinoids
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate
diphosphate + cannabigerolate
show the reaction diagram
additional information
?
-
-
the enzyme accepts geranyldiphosphate and to a lesser degree also neryldiphosphate as a cosubstrate. Olivetol is inactive as a prenyl acceptor, GOT is specific for olivetolic acid
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate
diphosphate + cannabigerolate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
essentially required
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
-
Michaelis-Menten kinetics with geranyl diphosphate as substrate
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
young
Manually annotated by BRENDA team