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Information on EC 2.4.99.5 - galactosyldiacylglycerol alpha-2,3-sialyltransferase Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The enzyme appears in viruses and cellular organisms
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galactosyldiacylglycerol alpha-2,3-sialyltransferase
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CMP-N-acetyl-beta-neuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol = CMP + 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol
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glycosyl group transfer
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Glycerolipid metabolism
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CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase
The beta-D-galactosyl residue of the oligosaccharide of glycoproteins may also act as acceptor.
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Galbeta-1,4/3-GlcNAcalpha-2,3-(N)-sialyltransferase
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sialyltransferase, cytidine monophosphoacetylneuraminate-galactosyldiacylglycerol
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Swiss-Webster albino
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recombinant enzyme
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CMP-N-acetylneuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol
CMP + 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol
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i.e. galactosyldiacylglycerol, transfers N-acetylneuraminic acid to position C-3 of the galactosyl residue
i.e. sialosylgalactosyldiacylglycerol
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CMP-N-acetylneuraminate + Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc
CMP + ?
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i.e. lacto-N-tetraose
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CMP-N-acetylneuraminate + Galbeta1-3GlcNAcR
CMP + NeuAcalpha2-3Galbeta1-3GlcNAcR
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i.e. rat asialo alpha1 acid glycoprotein
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CMP-N-acetylneuraminate + Galbeta1-4GlcNAc
CMP + NeuAcalpha2-3Galbeta1-4GlcNAc
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i.e. N-acetyllactosamine
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CMP-N-acetylneuraminate + Galbeta1-4GlcNAcR
CMP + NeuAcalpha2-3Galbeta1-4GlcNAcR
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i.e. human asialo alpha1 acid glycoprotein
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CMP-N-acetylneuraminic acid + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol
CMP + 1,2-diacyl-3-[3-(alpha-D-N-acetyl-neuraminyl)-beta-D-galactosyl]-sn-glycerol
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CMP-N-acetylneuraminic acid + NeuAcalpha-(2-3)-Galbeta-(1-4)-GlcNAcbeta-1-octyl
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activity of the recombinant enzyme with sialylated beta-D-Gal-(1-3)-alpha-D-GalNAc-octyl containing oligosaccharides, synthesized in analogy to oligosaccharides found on mucin type complex O-glycans, overview
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CMP-N-acetylneuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol
CMP + 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol
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i.e. galactosyldiacylglycerol, transfers N-acetylneuraminic acid to position C-3 of the galactosyl residue
i.e. sialosylgalactosyldiacylglycerol
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0.057 - 0.78
CMP-acetylneuraminate
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galactosyldiacylglycerol
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0.11
Galbeta1-3GlcNAcbeta1-1Galbeta1-4Glc
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0.18
Galbeta1-3GlcNAcR
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0.18
Galbeta1-4GlcNaAcR
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2.43
Galbeta1-4GlcNAc
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0.26
Galbeta1-4GlcNAcR
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additional information
additional information
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0.057
CMP-acetylneuraminate
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0.78
CMP-acetylneuraminate
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additional information
additional information
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comparison of kinetic properties of sialyltransferases
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additional information
additional information
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kinetics
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assay at
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biotechnology
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use for chemoenzymatic synthesis of 13C-labeled sialyloligosaccharide
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Pieringer, J.; Keech, S.; Pieringer, R.A.
Biosynthesis in vitro of sialosylgalactosyldiacylglycerol by mouse brain microsomes
J. Biol. Chem.
256
12306-12309
1981
Mus musculus
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Miyazaki, T.; Sato, H.; Sakakibara, T.; Kajihara, Y.
An approach to the precise chemoenzymatic synthesis of 13C-labeled sialyloligosaccharide on an intact glycoprotein: A novel one-pot [3-13C]-labeling method for sialic acid analogues by control of the reversible aldolase reaction, enzymatic synthesis of [3-13C]-NeuAc-a-(2->3)-[U-13C]-Gal-b-(1->4)-GlcNAc-b- sequence onto glycoprotein, and its conformational analysis by developed NMR techniques
J. Am. Chem. Soc.
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5678-5694
2000
Rattus norvegicus
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Williams, M.A.; Kitagawa, H.; Datta, A.K.; Paulson, J.C.; Jamieson, J.C.
Large-scale expression of recombinant sialyltransferases and comparison of their kinetic properties with native enzymes
Glycoconjugate J.
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755-761
1995
Rattus norvegicus
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Sengupta, P.; Misra, A.K.; Suzuki, M.; Fukuda, M.; Hindsgaul, O.
Chemoenzymatic synthesis of sialylated oligosaccharides for their evaluation in a polysialyltransferase assay
Tetrahedron Lett.
44
6037-6042
2003
Rattus norvegicus
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brenda
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