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Information on EC 2.4.99.17 - S-adenosylmethionine:tRNA ribosyltransferase-isomerase

for references in articles please use BRENDA:EC2.4.99.17
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EC Tree
IUBMB Comments
The reaction is a combined transfer and isomerization of the ribose moiety of S-adenosyl-L-methionine to the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. It is part of the queuosine biosynthesis pathway.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
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7-aminomethyl-7-carbaguanosine34 in tRNA
=
+
+
epoxyqueuosine34 in tRNA
Synonyms
s-adenosylmethionine:trna ribosyltransferase-isomerase, quea enzyme, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine34 in tRNA = L-methionine + adenine + epoxyqueuosine34 in tRNA
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PATHWAY SOURCE
PATHWAYS
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