Information on EC 2.4.2.58 - hydroxyproline O-arabinosyltransferase

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The expected taxonomic range for this enzyme is: Arabidopsis thaliana

EC NUMBER
COMMENTARY hide
2.4.2.58
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RECOMMENDED NAME
GeneOntology No.
hydroxyproline O-arabinosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-beta-L-arabinofuranose + [protein]-trans-4-hydroxy-L-proline = UDP + [protein]-O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-proline
show the reaction diagram
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UDP-beta-L-arabinofuranose + [protein]-trans-4-hydroxy-L-proline = UDP + [protein]-trans-4-(beta-L-arabinofuranosyl)oxy-L-proline
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Other types of O-glycan biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
UDP-beta-L-arabinofuranose:[protein]-trans-4-hydroxy-L-proline L-arabinofuranosyl transferase (configuration-retaining)
The enzyme, found in plants and mosses, catalyses the O-arabinosylation of hydroxyprolines in hydroxyproline-rich glycoproteins. The enzyme acts on the first hydroxyproline in the motif Val-hydroxyPro-hydroxyPro-Ser.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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loss-of-function mutations in hydroxyproline O-arabinosyltransferase-encoding genes cause pleiotropic phenotypes that include enhanced hypocotyl elongation, defects in cell wall thickening, early flowering, early senescence and impaired pollen tube growth
physiological function
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essential role of Hyp O-arabinosylation in both vegetative and reproductive growth (hypocotyl elongation, cell wall thickening, flowering, senescence and pollen tube growth)
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-beta-L-arabinofuranose + [protein]-trans-4-hydroxy-L-proline
UDP + [protein]-trans-4-(beta-L-arabinofuranosyl)oxy-L-proline
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-beta-L-arabinofuranose + [protein]-trans-4-hydroxy-L-proline
UDP + [protein]-trans-4-(beta-L-arabinofuranosyl)oxy-L-proline
show the reaction diagram
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the enzyme catalyses the O-arabinosylation of hydroxyprolines in hydroxyproline-rich glycoproteins. The enzyme acts on the first hydroxyproline in the motif Val-hydroxyPro-hydroxyPro-Ser
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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Golgi-localized transmembrane protein
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE