Information on EC 2.4.2.55 - nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Sporomusa ovata

EC NUMBER
COMMENTARY hide
2.4.2.55
-
RECOMMENDED NAME
GeneOntology No.
nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
nicotinate D-ribonucleotide + phenol = nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
The enzyme is involved in the biosynthesis of phenolic cobamides in the Gram-positive bacterium Sporomusa ovata. It can also transfer the phospho-D-ribosyl group to 4-methylphenol and 5,6-dimethylbenzimidazole. The related EC 2.4.2.21, nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase, also transfers the phospho-D-ribosyl group from nicotinate D-ribonucleotide to 5,6-dimethylbenzimidazole, but shows no activity with 4-methylphenol or phenol.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
the enzyme is involved in the biosynthesis of phenolic cobamides in Sporomusa ovata
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
beta-nicotinate D-ribonucleotide + 4-cresol
nicotinate + 4-methylphenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole
nicotinate + alpha-ribazole 5'-phosphate
show the reaction diagram
beta-nicotinate D-ribonucleotide + phenol
nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
beta-nicotinate D-ribonucleotide + 4-cresol
nicotinate + 4-methylphenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
-
the enzyme is involved in the biosynthesis of phenolic cobamides in Sporomusa ovata
-
-
?
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole
nicotinate + alpha-ribazole 5'-phosphate
show the reaction diagram
-
the enzyme is involved in the biosynthesis of phenolic cobamides in Sporomusa ovata
-
-
?
beta-nicotinate D-ribonucleotide + phenol
nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside
show the reaction diagram
-
the enzyme is involved in the biosynthesis of phenolic cobamides in Sporomusa ovata
-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.019
-
pH 9.0, 37°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
66000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterodimer
-
1 * 36650 (ArsA) + 1 * 361800 (ArsB), calculated from sequence
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE