Information on EC 2.4.2.52 - triphosphoribosyl-dephospho-CoA synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.4.2.52
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RECOMMENDED NAME
GeneOntology No.
triphosphoribosyl-dephospho-CoA synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
substituted phospho group transfer
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transfer of 3-dephospho-CoA
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
citrate lyase activation
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malonate decarboxylase activation
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SYSTEMATIC NAME
IUBMB Comments
ATP:3'-dephospho-CoA 5-triphospho-alpha-D-ribosyltransferase
ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new alpha (1''->2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (gamma-subunit) of EC 4.1.3.6, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66, malonate decarboxylase holo-[acyl-carrier protein] synthase [4].
CAS REGISTRY NUMBER
COMMENTARY hide
313345-38-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
biovar diacetylactis CRL264
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 3'-dephospho-CoA
2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine
show the reaction diagram
ATP + 3-dephospho-CoA
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 3-dephospho-CoA
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine
show the reaction diagram
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20 - 25
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at room temperature
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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? * 32600, SDS-PAGE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme is part of the citrate lyase gene cluster, citCDEFXG
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Show AA Sequence (2516 entries)
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