Reference on EC 2.4.1.B62 - small GTPase glucosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, H.; Kim, W.H.; Kim, M.; Jeong, S.H.; Lee, K.
Evaluation of a rapid membrane enzyme immunoassay for the simultaneous detection of glutamate dehydrogenase and toxin for the diagnosis of Clostridium difficile infection
Ann. Lab. Med.
34
235-239
2014
Clostridioides difficile
Faust, C.; Ye, B.; Song, K.
The enzymatic domain of Clostridium difficile toxin A is located within its N-terminal region
Biochem. Biophys. Res. Commun.
251
100-105
1998
Clostridioides difficile (P16154)
Castagliuolo, I.; Sardina, M.; Brun, P.; DeRos, C.; Mastrotto, C.; Lovato, L.; Palu, G.
Clostridium difficile toxin A carboxyl-terminus peptide lacking ADP-ribosyltransferase activity acts as a mucosal adjuvant
Infect. Immun.
72
2827-2836
2004
Clostridioides difficile, Clostridioides difficile VPI 10463
Bobo, L.D.; El Feghaly, R.E.; Chen, Y.S.; Dubberke, E.R.; Han, Z.; Baker, A.H.; Li, J.; Burnham, C.A.; Haslam, D.B.
MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation
Infect. Immun.
81
713-722
2013
Clostridioides difficile
Just, I.; Wilm, M.; Selzer, J.; Rex, G.; von Eichel-Streiber, C.; Mann, M.; Aktories, K.
The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins
J. Biol. Chem.
270
13932-13936
1995
Clostridioides difficile (P16154)
Just, I.; Selzer, J.; Hofmann, F.; Green, G. A.; Aktories, K.
Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation
J. Biol. Chem.
271
10149-10153
1996
Paeniclostridium sordellii (Q46342), Paeniclostridium sordellii 6018 (Q46342)
Jank, T.; Reinert, D.; Giesemann, T.; Schulz, G.; Aktories, K.
Change of the donor substrate specificity of Clostridium difficile toxin B by site-directed mutagenesis
J. Biol. Chem.
280
37833-37838
2005
Clostridioides difficile (P18177), Clostridioides difficile, Clostridium novyi (Q46149), Clostridium novyi, Paeniclostridium sordellii (Q46342), Paeniclostridium sordellii, Paeniclostridium sordellii 6018 (Q46342), Clostridium novyi 19402 (Q46149), Clostridioides difficile VPI 10463 (P18177)
Egerer, M.; Giesemann, T.; Jank, T.; Satchell, K.J.; Aktories, K.
Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity
J. Biol. Chem.
282
25314-25321
2007
Clostridioides difficile (P16154), Clostridioides difficile (P18177)
Pruitt, R.; Chumbler, N.; Rutherford, S.; Farrow, M.; Friedman, D.; Spiller, B.; Lacy, D.
Structural determinants of Clostridium difficile toxin A glucosyltransferase activity
J. Biol. Chem.
287
8013-8020
2012
Clostridioides difficile (Q189K5), Clostridioides difficile 630 (Q189K5)
Shoshan, M.; Florin, I.; Thelestam, M.
Activation of cellular phospholipase A2 by Clostridium difficile toxin B
J. Cell. Biochem.
52
116-124
1993
Clostridioides difficile
Just, I.; Selzer, J.; Von Eichel-Streiber, C.; Aktories, K.
The low molecular mass GTP-binding protein Rho is affected by toxin A from Clostridium difficile
J. Clin. Invest.
95
1026-1031
1995
Clostridioides difficile
Sharp, S.E.; Ruden, L.O.; Pohl, J.C.; Hatcher, P.A.; Jayne, L.M.; Ivie, W.M.
Evaluation of the C.Diff Quik Chek Complete Assay, a new glutamate dehydrogenase and A/B toxin combination lateral flow assay for use in rapid, simple diagnosis of Clostridium difficile disease
J. Clin. Microbiol.
48
2082-2086
2010
Clostridioides difficile
Mitchell, T.; Ketley, J.; Burdon, D.; Candy, D.; Stephen, J.
The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro
J. Med. Microbiol.
23
205-210
1987
Clostridioides difficile
Torres, J.
Purification and characterisation of toxin B from a strain of Clostridium difficile that does not produce toxin A
J. Med. Microbiol.
35
40-44
1991
Clostridioides difficile, Clostridioides difficile 8864
Blake, J.; Mitsikosta, F.; Metcalfe, M.
Immunological detection and cytotoxic properties of toxins from toxin A-positive, toxin B-positive Clostridium difficile variants
J. Med. Microbiol.
53
197-205
2004
Clostridioides difficile
Nam, S.T.; Seok, H.; Kim, D.H.; Nam, H.J.; Kang, J.K.; Eom, J.H.; Lee, M.B.; Kim, S.K.; Park, M.J.; Chang, J.S.; Ha, E.M.; Shong, K.E.; Hwang, J.S.; Kim, H.
Clostridium difficile toxin A inhibits erythropoietin receptor-mediated colonocyte focal adhesion through inactivation of Janus Kinase-2
J. Microbiol. Biotechnol.
22
1629-1635
2012
Clostridioides difficile, Clostridioides difficile VPI 10463
Seok, H.; Nam, H.J.; Nam, S.T.; Kang, J.K.; Kim, S.K.; Chang, J.S.; Ha, E.M.; Park, Y.J.; Kim, H.
Clostridium difficile toxin A inhibits the kinase activity of extracellular signal-related kinases 1 and 2 through direct binding
J. Microbiol. Biotechnol.
22
170-175
2012
Clostridioides difficile, Clostridioides difficile VPI 10463
Reinert, D.; Jank, T.; Aktories, K.; Schulz, G.
Structural basis for the function of Clostridium difficile toxin B
J. Mol. Biol.
351
973-981
2005
Clostridioides difficile (P18177), Clostridioides difficile VPI 10463 (P18177)
Ziegler, M.O.; Jank, T.; Aktories, K.; Schulz, G.E.
Conformational changes and reaction of clostridial glycosylating toxins
J. Mol. Biol.
377
1346-1356
2007
Clostridium novyi (Q46149), Paeniclostridium sordellii (Q46342)
Ko, S.H.; Jeon, J.I.; Kim, H.; Kim, Y.J.; Youn, J.; Kim, J.M.
Mitogen-activated protein kinase/IkappaB kinase/NF-kappaB-dependent and AP-1-independent CX3CL1 expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A
J. Mol. Med.
92
411-427
2014
Clostridioides difficile
Savidge, T,C,; Urvil, P.;, Oezguen, N.; Ali, K.; Choudhury, A.; Acharya, V.; Pinchuk, I.; Torres, A.G., English, R.D.; Wiktorowicz, J.E.; Loeffelholz, M.; Kumar, R.; Shi, L.; Nie, W.; Braun, W.; Herman, B., Hausladen, A.; Feng, H.; Stamler, J.S.; Pothoulakis, C.
Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins
Nat. Med.
17
1136-1141
2011
Clostridioides difficile
Shen, A.; Lupardus, P.J.; Gersch, M.M.; Puri, A.W.; Albrow, V.E.; Garcia, K.C.; Bogyo, M.
Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins
Nat. Struct. Mol. Biol.
18
364-371
2011
Clostridioides difficile (Q189K3), Clostridioides difficile 630 (Q189K3)
Just, I.; Selzer, J.; Wilm, M.; von Eichel-Streiber, C.; Mann, M.; Aktories, K.
Glucosylation of Rho proteins by Clostridium difficile toxin B
Nature
375
500-503
1995
Clostridioides difficile
Vesenka, G.D.; Majumdar, A.P.; Dubick, M.A.; Lyerly, D.M.; Wilkins, T.D.; Silva, J.; Geokas, M.C.
Stimulation of enzyme secretion from isolated pancreatic acini by Clostridium difficile toxin B
Toxicol. Lett.
34
261-269
1986
Clostridioides difficile
Roberts, A.; Shone, C.
Modification of surface histidine residues abolishes the cytotoxic activity of Clostridium difficile toxin A
Toxicon
39
325-333
2000
Clostridioides difficile, Clostridioides difficile VPI 10463
Genth, H.; Pauillac, S.; Schelle, I.; Bouvet, P.; Bouchier, C.; Varela-Chavez, C.; Just, I.; Popoff, M.R.
Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins
Cell. Microbiol.
16
1706-1721
2014
Paeniclostridium sordellii (M9ZTT7), Paeniclostridium sordellii (V5T923), Paeniclostridium sordellii, Paeniclostridium sordellii vpi9048 (M9ZTT7), Paeniclostridium sordellii vpi9048 (V5T923)
Varela Chavez, C.; Hoos, S.; Haustant, G.M.; Chenal, A.; England, P.; Blondel, A.; Pauillac, S.; Lacy, D.B.; Popoff, M.R.
The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid
Cell. Microbiol.
17
1477-1493
2015
Paeniclostridium sordellii (V5T923), Paeniclostridium sordellii
Baliban, S.M.; Michael, A.; Shammassian, B.; Mudakha, S.; Khan, A.S.; Cocklin, S.; Zentner, I.; Latimer, B.P.; Bouillaut, L.; Hunter, M.; Marx, P.; Sardesai, N.Y.; Welles, S.L.; Jacobson, J.M.; Weiner, D.B.; Kutzler, M.A.
An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo
Infect. Immun.
82
4080-4091
2014
Clostridioides difficile (P16154), Clostridioides difficile (P18177)
Kasendra, M.; Barrile, R.; Leuzzi, R.; Soriani, M.
Clostridium difficile toxins facilitate bacterial colonization by modulating the fence and gate function of colonic epithelium
J. Infect. Dis.
209
1095-1104
2014
Clostridioides difficile (P16154)
Varela Chavez, C.; Haustant, G.M.; Baron, B.; England, P.; Chenal, A.; Pauillac, S.; Blondel, A.; Popoff, M.R.
The tip of the four N-terminal alpha-helices of Clostridium sordellii lethal toxin contains the interaction site with membrane phosphatidylserine facilitating small GTPases glucosylation
Toxins
8
90
2016
Paeniclostridium sordellii (V5T923), Paeniclostridium sordellii
Thiele, T.L.; Stuber, T.P.; Hauer, P.J.
Detection of Clostridium sordellii strains expressing hemorrhagic toxin (TcsH) and implications for diagnostics and regulation of veterinary vaccines
Vaccine
31
5082-5087
2013
Paeniclostridium sordellii (M9ZTT7), Paeniclostridium sordellii (V5T923), Paeniclostridium sordellii, Paeniclostridium sordellii VPI 9048 (M9ZTT7), Paeniclostridium sordellii VPI 9048 (V5T923)
Genth, H.; Schelle, I.; Just, I.
Metal ion activation of Clostridium sordellii lethal toxin and Clostridium difficile toxin B
Toxins
8
109
2016
Clostridioides difficile (P18177), Clostridioides difficile, Paeniclostridium sordellii (V5T923), Paeniclostridium sordellii
Genth, H.; Junemann, J.; Laemmerhirt, C.M.; Luecke, A.C.; Schelle, I.; Just, I.; Gerhard, R.; Pich, A.
Difference in mono-O-glucosylation of Ras subtype GTPases between toxin A and toxin B from Clostridioides difficile strain 10463 and lethal toxin from Clostridium sordellii strain 6018
Front. Microbiol.
9
3078
2018
Clostridioides difficile (P16154), Clostridioides difficile (P18177), Clostridioides difficile, Paeniclostridium sordellii (Q46342), Paeniclostridium sordellii, Paeniclostridium sordellii 6018 (Q46342), Clostridioides difficile 10463 (P16154), Clostridioides difficile 10463 (P18177)
Craven, R.; Lacy, D.
Clostridium sordellii lethal-toxin autoprocessing and membrane localization activities drive GTPase glucosylation profiles in endothelial cells
mSphere
1
e00012-15
2016
Paeniclostridium sordellii (Q46342), Paeniclostridium sordellii, Paeniclostridium sordellii JGS6382 (Q46342)
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