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Disease on EC 2.4.1.90 - N-acetyllactosamine synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.
Arthritis, Rheumatoid
beta1,4-Galactosyltransferase-I contributes to the inflammatory processes in synovial tissue of patients with rheumatoid arthritis.
Asthma
Genome-wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.
Astrocytoma
Over-expression of beta-1,4-galactosyltransferase I, II, and V in human astrocytoma.
Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line.
Atherosclerosis
Platelet derived growth factor recruits lactosylceramide to induce cell proliferation in UDP Gal:GlcCer: beta1 --> 4Galactosyltransferase (GalT-V) mutant Chinese hamster ovary cells.
Biliary Tract Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Breast Neoplasms
?1,4-Galactosyltransferase V Modulates Breast Cancer Stem Cells through Wnt/?-catenin Signaling Pathway.
Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.
Carcinogenesis
beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization.
Carcinoma
Expression of galactosyltransferase in prostatic tumors.
Increase in beta-1,4-galactosyltransferase activity during PC12 cell differentiation induced by forskolin and 2-chloroadenosine.
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Carcinoma, Ehrlich Tumor
Ehrlich ascites tumor cell UDP-Gal:N-acetyl-D-glucosamine beta(1,4)-galactosyltransferase. Purification, characterization, and topography of the acceptor-binding site.
Carcinoma, Embryonal
Cell surface and Golgi pools of beta-1,4-galactosyltransferase are differentially regulated during embryonal carcinoma cell differentiation.
Characterization of a murine beta 1-4 galactosyltransferase expressed in COS-1 cells.
Dominant negative mutation in cell surface beta 1,4-galactosyltransferase inhibits cell-cell and cell-matrix interactions.
Effects of overexpression of beta 1,4-galactosyltransferase on glycoprotein biosynthesis in F9 embryonal carcinoma cells.
Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase.
Carcinoma, Hepatocellular
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Colonic Neoplasms
Characterization of monoclonal antibodies to serum galactosyltransferase.
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Colorectal Neoplasms
Lactosylceramide synthase ?-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer.
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis.
Connective Tissue Diseases
Determination of beta4-galactosyltransferase-7 activity using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Ehlers-Danlos Syndrome
Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family.
Esophageal Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Gastrointestinal Neoplasms
Characterization of monoclonal antibodies to serum galactosyltransferase.
Glioblastoma
B4GALT3 promotes cell proliferation and invasion in glioblastoma.
Over-expression of beta-1,4-galactosyltransferase I, II, and V in human astrocytoma.
Glioma
Beta1,4-galactosyltransferase V A growth regulator in glioma.
Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma.
beta1,4-Galactosyltransferase V regulates self-renewal of glioma-initiating cell.
Down-regulation of beta1,4-galactosyltransferase V is a critical part of etoposide-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells.
Down-regulation of the expression of beta1,4-galactosyltransferase V promotes integrin beta1 maturation.
Glomerulonephritis, IGA
Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in Beta-1,4-galactosyltransferase-deficient mice.
Herpes Zoster
Aggregation of beta-1,4-galactosyltransferase on mouse sperm induces the acrosome reaction.
Binding of caput epididymal mouse sperm to the zona pellucida.
Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling.
Characterization of a novel ZP3-independent sperm-binding ligand that facilitates sperm adhesion to the egg coat.
Egg cortical granule N-acetylglucosaminidase is required for the mouse zona block to polyspermy.
Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions.
Plasma membrane association, purification, and partial characterization of mouse sperm beta 1,4-galactosyltransferase.
Porcine sperm surface beta1,4galactosyltransferase binds to the zona pellucida but is not necessary or sufficient to mediate sperm-zona pellucida binding.
Receptor function of mouse sperm surface galactosyltransferase during fertilization.
Sperm from a variety of mammalian species express beta1,4-galactosyltransferase on their surface.
Sperm from beta1,4-galactosyltransferase I-null mice exhibit precocious capacitation.
Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida.
Sperm-egg binding requires a multiplicity of receptor-ligand interactions: new insights into the nature of gamete receptors derived from reproductive tract secretions.
Spermatozoa from a marsupial, the brushtail possum, contain beta1,4-galactosyltransferase.
The receptor function of galactosyltransferase during mammalian fertilization.
Infections
Beta-(1 --> 4)-galactosyltransferase activity in native and engineered insect cells measured with time-resolved europium fluorescence.
Insulin Resistance
Downregulation of ?1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation.
Leukemia
B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.
Liver Diseases
Characterization of monoclonal antibodies to serum galactosyltransferase.
Lung Neoplasms
Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator.
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Lymphatic Metastasis
?-1,4-Galactosyltransferase III suppresses ?1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer.
Mastocytoma
Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase.
Melanoma
Functionally distinct laminin receptors mediate cell adhesion and spreading: the requirement for surface galactosyltransferase in cell spreading.
The level of cell surface beta1,4-galactosyltransferase I influences the invasive potential of murine melanoma cells.
Melanoma, Experimental
Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.
Neoplasm Metastasis
?-1,4-Galactosyltransferase III suppresses ?1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer.
Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma.
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis.
Neoplasms
?-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via ?1-Integrin and Predicts Poor Prognosis in Neuroblastoma.
?1,4-Galactosyltransferase V Modulates Breast Cancer Stem Cells through Wnt/?-catenin Signaling Pathway.
B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.
Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer.
Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin.
Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
Ehrlich ascites tumor cell UDP-Gal:N-acetyl-D-glucosamine beta(1,4)-galactosyltransferase. Purification, characterization, and topography of the acceptor-binding site.
Estrogen induced ?-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells.
Expression of galactosyltransferase in prostatic tumors.
Gene-linked shift in ganglioside distribution influences growth and vascularity in a mouse astrocytoma.
Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.
Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma.
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Platelet derived growth factor recruits lactosylceramide to induce cell proliferation in UDP Gal:GlcCer: beta1 --> 4Galactosyltransferase (GalT-V) mutant Chinese hamster ovary cells.
The Immunological Regulation Roles of Porcine ?-1, 4 Galactosyltransferase V (B4GALT5) in PRRSV Infection.
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis.
Tumor necrosis factor-alpha up-regulates the expression of beta1,4-galactosyltransferase I in primary human endothelial cells by mRNA stabilization.
Up-regulation of lactosylceramide synthase in MDR1 overexpressing human liver tumour cells.
Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model.
Neuroblastoma
Long noncoding RNA differentiation antagonizing nonprotein coding RNA promotes the proliferation, invasion and migration of neuroblastoma cells via targeting ?-1, 4-galactosyltransferase III by sponging miR-338-3p.
Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases.
Ovarian Neoplasms
Integrated bioinformatic analysis identifies UBE2Q1 as a potential prognostic marker for high grade serous ovarian cancer.
Pancreatic Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Pneumonia
Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.
Prostatic Hyperplasia
Expression of galactosyltransferase in prostatic tumors.
Rotavirus Infections
Detection of an unusual G8P[8] rotavirus in a Rotarix-vaccinated child with acute gastroenteritis using Nanopore MinION sequencing: A case report.
Sarcoma, Avian
D-galactosyltransferase and its endogenous substrates in chick embryo fibroblasts transformed by Rous sarcoma virus.
Spinal Cord Injuries
Altered beta-1,4-galactosyltransferase I expression during early inflammation after spinal cord contusion injury.
Stomach Neoplasms
Overexpression of beta 1,4N-acetylgalactosaminyl- transferase mRNA as a molecular marker for various types of cancers.
Urinary Bladder Neoplasms
Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer.
Uterine Cervical Neoplasms
B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.
Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development.
Vesicular Stomatitis
Calsenilin and CALP interact with the cytoplasmic tail of UDP-Gal:GA2/GM2/GD2 beta-1,3-galactosyltransferase.
Whooping Cough
Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling.
Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFbeta signal transduction mechanisms.