Information on EC 2.4.1.52 - poly(glycerol-phosphate) alpha-glucosyltransferase

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The expected taxonomic range for this enzyme is: Bacillus subtilis

EC NUMBER
COMMENTARY hide
2.4.1.52
-
RECOMMENDED NAME
GeneOntology No.
poly(glycerol-phosphate) alpha-glucosyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-glucose + poly(glycerol phosphate) = UDP + O-(alpha-D-glucosyl)poly(glycerol phosphate)
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
poly(glycerol phosphate) wall teichoic acid biosynthesis
-
-
teichoic acid biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37277-60-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
NCTC 3610
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dTDP-glucose + poly(glycerophosphate)
dTDP + alpha-D-glucosyl-poly(glycerol phosphate)
show the reaction diagram
-
-
-
-
?
UDP-glucose + poly(glycerophosphate)
UDP + alpha-D-glucosyl-poly(glycerol phosphate)
show the reaction diagram
-
-
-
-
?
UDPglucose + poly(glycerophosphate)
UDP + alpha-D-glucosyl-poly(glycerol phosphate)
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDPglucose + poly(glycerophosphate)
UDP + alpha-D-glucosyl-poly(glycerol phosphate)
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
requirement, as active as Mg2+
Mg2+
-
requirement
Mn2+
-
requirement, much less effective than Mg2+ and inhibitory in presence of optimal Mg2+ concentration
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Mn2+
-
inhibitory in presence of optimal Mg2+-concentration
additional information
-
vancomycin, novobionin, crystal violet are no inhibitors
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1 - 2
poly(glycerophosphate)
-
depending on chain length
0.04
UDPglucose
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 9.5
-
15% of maximal activity at pH 5.5, 60% of maximal activity at pH 9.5
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Show AA Sequence (480 entries)
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