Reference on EC 2.4.1.41 - polypeptide N-acetylgalactosaminyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sugiura, M.; Kawasaki, T.; Yamashina, I.
Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66
J. Biol. Chem.
257
9501-9507
1982
Rattus norvegicus
Takeuchi, M.; Yoshikawa, M.; Sasaki, R.; Chiba, R.
Purification and characterization of UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase from mammary gland of lacting cow
Agric. Biol. Chem.
49
1059-1069
1985
Bos taurus
-
Wang, Y.; Agrwal, N.; Eckhardt, A.E.; Stevens, R.D.; Hill, R.L.
The acceptor substrate specificity of porcine submaxillary UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is dependent on the amino acid sequences adjacent to serine and threonine residues
J. Biol. Chem.
268
22979-22983
1993
Sus scrofa
Wang, Y.; Abernethy, J.L.; Eckhardt, A.E.; Hill, R.L.
Purification and characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase specific for glycosylation of threonine residues
J. Biol. Chem.
267
12709-12716
1992
Sus scrofa
Hatanaka, K.; Slama, J.T.; Elbein, A.D.
Synthesis of a new inhibitor of the UDP-GalNAc:polypeptide galactosaminyl transferase
Biochem. Biophys. Res. Commun.
175
668-672
1991
Sus scrofa
Elhammer, A.; Kornfeld, S.
Purification and characterization of UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase from bovine colostrum and murine lymphoma BW5147 cells
J. Biol. Chem.
261
5249-5255
1986
Bos taurus, Mus musculus
Briand, J.P.; Andrews, S.P.; Cahill, E.; Conway, N.A.; Young, J.D.
Investigation of the requirements for O-glycosylation by bovine submaxillary gland UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosamine transferase using synthetic peptide substrates
J. Biol. Chem.
256
12205-12207
1981
Bos taurus
Cottrell, J.M.; Hall, R.L.; Sturton, R.G.; Kent, P.W.
Polypeptide N-acetylgalactosaminyltransferase activity in tracheal epithelial microsomes
Biochem. J.
283
299-305
1992
Sus scrofa
Homa, F.L.; Baker, C.A.; Thomsen, D.R.; Elhammer, A.P.
Conversion of a bovine UDP-GalNAc:polypeptide, N-acetylgalactosaminyltransferase to a soluble, secreted enzyme, and expression in Sf9 cells
Protein Expr. Purif.
6
141-148
1995
Bos taurus
Brockhausen, I.; Toki, D.; Brockhausen, J.; Peters, S.; Bielfeldt, T.; Kleen, A.; Paulsen, H.; Meldal, M.; Hagen, F.; Tabak, L.A.
Specificity of O-glycosylation by bovine colostrum UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase using synthetic glycopeptide substrates
Glycoconj. J.
13
849-856
1996
Bos taurus
Mendicino, J.; Sangadala, S.
Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase from swine trachea epithelium
Mol. Cell. Biochem.
185
135-145
1998
Sus scrofa
Soerensen, T.; White, T.; Wandall, H.H.; Kristensen, A.K.; Roepstorff, P.; Clausen, H.
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Identification and separation of two distinct transferase activities
J. Biol. Chem.
270
24166-24173
1995
Homo sapiens, Ovis sp., Rattus norvegicus, Sus scrofa
Wandall, H.H.; Hassan, H.; Mirgorodskaya, E.; Kristensen, A.K.; Roepstorff, P.; Bennett, E.P.; Nielsen, P.A.; Hollingsworth, M.A.; Burchell, J.; Taylor-Papadimitriou, J.; Clausen, H.
Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3
J. Biol. Chem.
272
23503-23514
1997
Homo sapiens
Bennett, E.P.; Hassan, H.; Hollingsworth, M.A.; Clausen, H.
A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates
FEBS Lett.
460
226-230
1999
Homo sapiens (Q86SF2), Homo sapiens
Toba, S.; Tenno, M.; Konishi, M.; Mikami, T.; Itoh, N.; Kurosaka, A.
Brain-specific expression of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T9)
Biochim. Biophys. Acta
1493
264-268
2000
Homo sapiens
Ten Hagen, K.G.; Bedi, G.S.; Tetaert, D.; Kingsley, P.D.; Hagen, F.K.; Balys, M.M.; Beres, T.M.; Degand, P.; Tabak, L.A.
Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9
J. Biol. Chem.
276
17395-17404
2001
Mus musculus, Rattus norvegicus (Q925R7)
Wang, H.; Tachibana, K.; Zhang, Y.; Iwasaki, H.; Kameyama, A.; Cheng, L.; Guo, J.; Hiruma, T.; Togayachi, A.; Kudo, T.; Kikuchi, N.; Narimatsu, H.
Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14
Biochem. Biophys. Res. Commun.
300
738-744
2003
Homo sapiens
Zhang, Y.; Iwasaki, H.; Wang, H.; Kudo, T.; Kalka, T.B.; Hennet, T.; Kubota, T.; Cheng, L.; Inaba, N.; Gotoh, M.; Togayachi, A.; Guo, J.; Hisatomi, H.; Nakajima, K.; Nishihara, S.; Nakamura, M.; Marth, J.D.; Narimatsu, H.
Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen
J. Biol. Chem.
278
573-584
2003
Homo sapiens, Homo sapiens (Q8IUC8), Mus musculus
Ten Hagen, K.G.; Tetaert, D.; Hagen, F.K.; Richet, C.; Beres, T.M.; Gagnon, J.; Balys, M.M.; VanWuyckhuyse, B.; Bedi, G.S.; Degand, P.; Tabak, L.A.
Characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase that displays glycopeptide N-acetylgalactosaminyltransferase activity
J. Biol. Chem.
274
27867-27874
1999
Mus musculus, Rattus norvegicus (Q9R0C5)
Elhammer, A.P.; Poorman, R.A.; Brown, E.; Maggiora, L.L.; Hoogerheide, J.G.; Kezdy, F.J.
The specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase as inferred from a database of in vivo substrates and from the in vitro glycosylation of proteins and peptides
J. Biol. Chem.
268
10029-10038
1993
Bos taurus
Hanisch, F.G.; Reis, C.A.; Clausen, H.; Paulsen, H.
Evidence for glycosylation-dependent activities of polypeptide N-acetylgalactosaminyltransferases rGalNAc-T2 and -T4 on mucin glycopeptides
Glycobiology
11
731-740
2001
Homo sapiens
Iwasaki, H.; Zhang, Y.; Tachibana, K.; Gotoh, M.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Kubota, T.; Narimatsu, H.
Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2
J. Biol. Chem.
278
5613-5621
2003
Homo sapiens
Hagen, F.K.; Hazes, B.; Raffo, R.; deSa, D.; Tabak, L.A.
Structure-function analysis of the UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase. Essential residues lie in a predicted active site cleft resembling a lactose repressor fold
J. Biol. Chem.
274
6797-6803
1999
Mus musculus
Tenno, M.; Saeki, A.; Kezdy, F.J.; Elhammer, A.P.; Kurosaka, A.
The lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 is involved in O-glycosylation of a polypeptide with multiple acceptor sites
J. Biol. Chem.
277
47088-47096
2002
Rattus norvegicus
Ten Hagen, K.G.; Tran, D.T.
A UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is essential for viability in Drosophila melanogaster
J. Biol. Chem.
277
22616-22622
2002
Drosophila melanogaster (Q8MVS5), Drosophila melanogaster
Hennebicq, S.; Tetaert, D.; Soudan, B.; Briand, G.; Richet, C.; Demeyer, D.; Gagnon, J.; Petillot, Y.; Degand, P.
Polypeptide:N-acetylgalactosaminyltransferase activities towards the mucin MUC5AC peptide motif using microsomal preparations of normal and tumoral digestive mucosa
Biochimie
80
69-73
1998
Homo sapiens
Takeuchi, H.; Kato, K.; Hassan, H.; Clausen, H.; Irimura, T.
O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines. Distinct specificity of GalNAc-transferase isoforms
Eur. J. Biochem.
269
6173-6183
2002
Homo sapiens
Wojczyk, B.S.; Stwora-Wojczyk, M.M.; Hagen, F.K.; Striepen, B.; Hang, H.C.; Bertozzi, C.R.; Roos, D.S.; Spitalnik, S.L.
cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii
Mol. Biochem. Parasitol.
131
93-107
2003
Toxoplasma gondii (Q8MM26), Toxoplasma gondii
Katao, K.; Takeuchi, H.; Miyahara, N.; Kanoh, A.; Hassan, H.; Clausen, H.; Irimura, T.
Distinct orders of GalNAc incorporation into a peptide with consecutive threonines
Biochem. Biophys. Res. Commun.
287
110-115
2001
Homo sapiens
Iida, S.I.; Takeuchi, H.; Kato, K.; Yamamoto, K.; Irimura, T.
Order and maximum incorporation of N-acetyl-D-galactosamine into threonine residues of MUC2 core peptide with microsome fraction of human-colon-carcinoma LS174T cells
Biochem. J.
347
535-542
2000
Homo sapiens
Hagen, F.K.; Nehrke, K.
cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans
J. Biol. Chem.
273
8268-8277
1998
Caenorhabditis elegans
Wragg, S.; Hagen, F.K.; Tabak, L.A.
Identification of essential histidine residues in UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T1
Biochem. J.
328
193-197
1997
Bos taurus
-
Hagen, F.K.; Ten Hagen, K.G.; Beres, T.M.; Balys, M.M.; Van Wuyckhuyse, B.C.; Tabak, L.A.
cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
J. Biol. Chem.
272
13843-13848
1997
Mus musculus
Wragg, S.; Hagen, F.K.; Tabak, L.A.
Kinetic analysis of a recombinant UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
J. Biol. Chem.
270
16947-16954
1995
Bos taurus
Roth, J.; Wang, Y.; Eckhardt, A.E.; Hill, R.L.
Subcellular localization of the UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-mediated O-glycosylation reaction in the submaxillary gland
Proc. Natl. Acad. Sci. USA
91
8935-8939
1994
Bos taurus, Sus scrofa
Nishimaori, I.; Fontenot, J.D.; Hollingsworth, M.A.
N-Acetylgalactosamine glycosylation of MUC1 tandem repeat peptides by pancreatic tumor cell extracts
Cancer Res.
54
3738-3744
1994
Homo sapiens
Marcos, N.T.; Cruz, A.; Silva, F.; Almeida, R.; David, L.; Mandel, U.; Clausen, H.; von Mensdorff-Pouilly, S.; Reis, C.A.
Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines
J. Histochem. Cytochem.
51
761-771
2003
Homo sapiens
Stwora-Wojczyk, M.M.; Dzierszinski, F.; Roos, D.S.; Spitalnik, S.L.; Wojczyk, B.S.
Functional characterization of a novel Toxoplasma gondii glycosyltransferase: UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3
Arch. Biochem. Biophys.
426
231-240
2004
Mus musculus, Rattus norvegicus, Toxoplasma gondii (Q6YBY0), Toxoplasma gondii
Zara, J.; Hagen, F.K.; Ten Hagen, K.G.; van Wuyckhuyse, B.C.; Tabak, L.A.
Cloning and expression of mouse UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3
Biochem. Biophys. Res. Commun.
228
38-44
1996
Mus musculus (P70419), Mus musculus
Freire, T.; Fernandez, C.; Chalar, C.; Maizels, R.M.; Alzari, P.; Osinaga, E.; Robello, C.
Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus
Biochem. J.
382
501-510
2004
Echinococcus granulosus
Nakamura, N.; Katano, K.; Toba, S.; Kurosaka, A.
Characterization of a novel polypeptide N-acetylgalactosaminyltransferase (dGalNAc-T3) from Drosophila
Biol. Pharm. Bull.
27
1509-1514
2004
Drosophila sp. (in: flies)
Nakamura, N.; Toba, S.; Hirai, M.; Morishita, S.; Mikami, T.; Konishi, M.; Itoh, N.; Kurosaka, A.
Cloning and expression of a brain-specific putative UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase gene
Biol. Pharm. Bull.
28
429-433
2005
Rattus norvegicus, Homo sapiens (Q9HCQ5), Homo sapiens
Guo, J.M.; Zhang, Y.; Cheng, L.; Iwasaki, H.; Wang, H.; Kubota, T.; Tachibana, K.; Narimatsu, H.
Molecular cloning; characterization of a novel member of the UDP-GalNAc polypeptide N-acetylgalactosaminyltransferase family,ppGalNAc-T12
FEBS Lett.
26297
1-8
2002
Homo sapiens (Q8IXK2)
-
Cheng, L.; Tachibana, K.; Iwasaki, H.; Kameyama, A.; Zhang, Y.; Kubota, T.; Hiruma, T.; Kudo, T.; Guo, J.M.; Narimatsu, H.
Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T15
FEBS Lett.
566
17-24
2004
Homo sapiens (Q10471), Homo sapiens (Q7Z4T8), Homo sapiens
Yoshida, A.; Hara, T.; Ikenaga, H.; Takeuchi, M.
Cloning and expression of a porcine UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase
Glycoconj. J.
12
824-828
1995
Sus scrofa (Q29121)
Hagen, F.K.; Gregoire, C.A.; Tabak, L.A.
Cloning and sequence homology of a rat UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
Glycoconj. J.
12
901-909
1995
Rattus norvegicus (Q10473)
Stwora-Wojczyk, M.M.; Kissinger, J.C.; Spitalnik, S.L.; Wojczyk, B.S.
O-glycosylation in Toxoplasma gondii: identification and analysis of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases
Int. J. Parasitol.
34
309-322
2004
Toxoplasma gondii (Q6TBR3), Toxoplasma gondii (Q6TBR4), Toxoplasma gondii (Q6YBY0), Toxoplasma gondii (Q6YK77), Toxoplasma gondii
Homa, F.L.; Hollander, T.; Lehman, D.J.; Thomsen, D.R.; Elhammer, A.P.
Isolation and expression of a cDNA clone encodinh a bovine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
J. Biol. Chem.
268
12609-12616
1993
Bos taurus (Q07537), Bos taurus
Hagen, F.K.; vanWyckhuyse, B.; Tabak, L.A.
Purification, cloning, and expression of a bovine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
J. Biol. Chem.
268
18960-18965
1993
Bos taurus (Q07537), Bos taurus
White, T.; Bennett, E.P.; Takio, K.; Sorensen, T.; Bonding, N.; Clausen, H.
Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
J. Biol. Chem.
270
24156-24165
1995
Homo sapiens (Q10471), Homo sapiens (Q10472), Homo sapiens
Bennett, E.P.; Hassan, H.; Clausen, H.
cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosaminyltransferase
J. Biol. Chem.
271
17006-17012
1996
Homo sapiens (Q14435), Homo sapiens
Ten hagen, K.G.; Hagen, F.K.; Balys, M.; Beres, T.M.; van Wuyckhuyse, B.; Tabak, L.A.
Cloning and expression of a novel, tissue specifically expressed member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family
J. Biol. Chem.
273
27749-27754
1998
Rattus norvegicus, Rattus norvegicus (O88422)
Bennett, R.P.; Hassan, H.; Mandel, U.; Mirgorodskaya, E.; et al.
Cloning of human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat
J. Biol. Chem.
273
30472-30481
1998
Homo sapiens (Q10471), Homo sapiens (Q10472), Homo sapiens (Q8N4A0), Homo sapiens
Bennett, E.P.; Hassan, H.; Mandel, U.; Hollingsworth, M.A.; Akisawa, N.; Ikematsu, Y.; Merkx, G.; van Kessel, A.G.; Olofsson, S.; Clausen, H.
Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6
J. Biol. Chem.
274
25362-25370
1999
Homo sapiens (Q8NCL4), Homo sapiens
Sschwientek, T.; Bennett, E.P.; Flores, C.; et al.
Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans and mammals
J. Biol. Chem.
277
22623-22638
2002
Homo sapiens (Q8NCW6), Homo sapiens
Ten Hagen, K.G.; Tran, D.T.; Gerken, T.A.; Stein, D.S.; Zhang, Z.
Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster
J. Biol. Chem.
278
35039-35048
2003
Drosophila melanogaster, Drosophila melanogaster (Q6WV16), Drosophila melanogaster (Q6WV17), Drosophila melanogaster (Q6WV19), Drosophila melanogaster (Q6WV20), Drosophila melanogaster (Q8IA42), Drosophila melanogaster (Q8MV48), Drosophila melanogaster (Q9Y117)
Casaravilla, C.; Freire, T.; Malgor, R.; Medeiros, A.; Osinaga, E.; Carmona, C.
Mucin-type O-glycosylation in helminth parasites from major taxonomic groups: evidence for widespread distribution of the Tn antigen (GalNAc-Ser/Thr) and identification of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity
J. Parasitol.
89
709-714
2003
Echinococcus granulosus, Fasciola hepatica, Toxocara canis
Sangadala, S.; Swain, J.B.; McNear, A.; Mendicino, J.
Cloning, expression and properties of porcine trachea UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase
Mol. Cell. Biochem.
266
117-126
2004
Sus scrofa
Fritz, T.A.; Hurley, J.H.; Trinh, L.B.; Shiloach, J.; Tabak, L.A.
The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1
Proc. Natl. Acad. Sci. USA
101
15307-15312
2004
Mus musculus (O08912), Mus musculus
Duclos, S.; Da Silva, P.; Vovelle, F.; Piller, F.; Piller, V.
Characterization of the UDP-N-acetylgalactosamine binding domain of bovine polypeptide alphaN-acetylgalactosaminyltransferase T1
Protein Eng. Des. Sel.
17
635-646
2004
Bos taurus
Fritz, T.A.; Raman, J.; Tabak, L.A.
Dynamic association between the catalytic and lectin domains of human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2
J. Biol. Chem.
281
8613-8619
2006
Homo sapiens
Brooks, S.A.; Carter, T.M.; Bennett, E.P.; Clausen, H.; Mandel, U.
Immunolocalisation of members of the polypeptide N-acetylgalactosaminyl transferase (ppGalNAc-T) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer
Acta Histochem.
109
273-284
2007
Homo sapiens (Q10471), Homo sapiens (Q10472), Homo sapiens (Q14435), Homo sapiens (Q8N4A0), Homo sapiens (Q8NCL4)
Herr, P.; Korniychuk, G.; Yamamoto, Y.; Grubisic, K.; Oelgeschlaeger, M.
Regulation of TGF-beta signalling by N-acetylgalactosaminyltransferase-like 1
Development
135
1813-1822
2008
Xenopus laevis
Tenno, M.; Saeki, A.; Elhammer, A.P.; Kurosaka, A.
Function of conserved aromatic residues in the Gal/GalNAc-glycosyltransferase motif of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1
FEBS J.
274
6037-6045
2007
Rattus norvegicus (Q10473)
Wandall, H.H.; Irazoqui, F.; Tarp, M.A.; Bennett, E.P.; Mandel, U.; Takeuchi, H.; Kato, K.; Irimura, T.; Suryanarayanan, G.; Hollingsworth, M.A.; Clausen, H.
The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation
Glycobiology
17
374-387
2007
Homo sapiens (Q10471), Homo sapiens (Q10472), Homo sapiens (Q8N4A0), Homo sapiens (Q8NCW6)
Gerken, T.A.; Hagen, K.G.; Jamison, O.
Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase orthologue pairs
Glycobiology
18
861-870
2008
Bos taurus (Q07537), Homo sapiens (Q10471), Drosophila melanogaster (Q6WV17), Drosophila melanogaster (Q6WV19)
Tian, E.; ten Hagen, K.G.
A UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is required for epithelial tube formation
J. Biol. Chem.
282
606-614
2007
Drosophila melanogaster (Q8MVS5)
Raman, J.; Fritz, T.A.; Gerken, T.A.; Jamison, O.; Live, D.; Liu, M.; Tabak, L.A.
The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase function in concert to direct glycosylation site selection
J. Biol. Chem.
283
22942-22951
2008
Homo sapiens
Milac, A.L.; Buchete, N.V.; Fritz, T.A.; Hummer, G.; Tabak, L.A.
Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2
J. Mol. Biol.
373
439-451
2007
Homo sapiens (Q10471)
Tenno, M.; Ohtsubo, K.; Hagen, F.K.; Ditto, D.; Zarbock, A.; Schaerli, P.; von Andrian, U.H.; Ley, K.; Le, D.; Tabak, L.A.; Marth, J.D.
Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity
Mol. Cell. Biol.
27
8783-8796
2007
Mus musculus
Wu, C.; Wang, Y.; Zou, M.; Shan, Y.; Yao, G.; Wei, P.; Chen, G.; Wang, J.; Xu, D.
Prokaryotic expression, purification, and production of polyclonal antibody against human polypeptide N-acetylgalactosaminyltransferase 14
Protein Expr. Purif.
56
1-7
2007
Homo sapiens (Q96FL9), Homo sapiens
Brockhausen, I.; Dowler, T.; Paulsen, H.
Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2
Biochim. Biophys. Acta
1790
1244-1257
2009
Bos taurus, Homo sapiens (Q10472)
Perrine, C.L.; Ganguli, A.; Wu, P.; Bertozzi, C.R.; Fritz, T.A.; Raman, J.; Tabak, L.A.; Gerken, T.A.
Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2
J. Biol. Chem.
284
20387-20397
2009
Bos taurus, Homo sapiens
Miwa, H.E.; Gerken, T.A.; Jamison, O.; Tabak, L.A.
Isoform-specific O-glycosylation of osteopontin and bone sialoprotein by polypeptide N-acetylgalactosaminyltransferase-1
J. Biol. Chem.
285
1208-1219
2010
Mus musculus
Gomes, J.; Marcos, N.T.; Berois, N.; Osinaga, E.; Magalhaes, A.; Pinto-de-Sousa, J.; Almeida, R.; Gaertner, F.; Reis, C.A.
Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma
J. Histochem. Cytochem.
57
79-86
2009
Homo sapiens
Guda, K.; Moinova, H.; He, J.; Jamison, O.; Ravi, L.; Natale, L.; Lutterbaugh, J.; Lawrence, E.; Lewis, S.; Willson, J.K.; Lowe, J.B.; Wiesner, G.L.; Parmigiani, G.; Barnholtz-Sloan, J.; Dawson, D.W.; Velculescu, V.E.; Kinzler, K.W.; Papadopoulos, N.; Vogelstein, B.; Willis, J.; Gerken, T.A.; Markowitz,
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers
Proc. Natl. Acad. Sci. USA
106
12921-12925
2009
Homo sapiens (Q8IXK2), Homo sapiens
Zlocowski, N.; Sendra, V.G.; Lorenz, V.; Villarreal, M.A.; Jorge, A.; Nunez, Y.; Bennett, E.P.; Clausen, H.; Nores, G.A.; Irazoqui, F.J.
Catalytic and glycan-binding abilities of ppGalNAc-T2 are regulated by acetylation
Biochem. Biophys. Res. Commun.
410
140-145
2011
Homo sapiens
Schjoldager, K.T.; Clausen, H.
Site-specific protein O-glycosylation modulates proprotein processing - Deciphering specific functions of the large polypeptide GalNAc-transferase gene family
Biochim. Biophys. Acta
1820
2079-2094
2012
Homo sapiens
Yoshimura, Y.; Nudelman, A.S.; Levery, S.B.; Wandall, H.H.; Bennett, E.P.; Hindsgaul, O.; Clausen, H.; Nishimura, S.
Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates
Glycobiology
22
429-438
2012
Homo sapiens
Li, X.; Wang, J.; Li, W.; Xu, Y.; Shao, D.; Xie, Y.; Xie, W.; Kubota, T.; Narimatsu, H.; Zhang, Y.
Characterization of ppGalNAc-T18, a member of the vertebrate-specific Y subfamily of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases
Glycobiology
22
602-615
2012
Homo sapiens (Q58A54)
Raman, J.; Guan, Y.; Perrine, C.L.; Gerken, T.A.; Tabak, L.A.
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree
Glycobiology
22
768-777
2012
Homo sapiens
Hua, D.; Shen, L.; Xu, L.; Jiang, Z.; Zhou, Y.; Yue, A.; Zou, S.; Cheng, Z.; Wu, S.
Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancer
Int. J. Mol. Med.
30
1267-1274
2012
Homo sapiens
Park, J.H.; Katagiri, T.; Chung, S.; Kijima, K.; Nakamura, Y.
Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin
Neoplasia
13
320-326
2011
Homo sapiens
Schjoldager, K.; Vakhrushev, S.; Kong, Y.; Steentoft, C.; Nudelman, A.; Pedersen, N.; Wandall, H.; Mandel, U.; Bennett, E.; Levery, S.; Clausen, H.
Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells
Proc. Natl. Acad. Sci. USA
109
9893-9898
2012
Homo sapiens
Lira-Navarrete, E.; Iglesias-Fernandez, J.; Zandberg, W.F.; Companon, I.; Kong, Y.; Corzana, F.; Pinto, B.M.; Clausen, H.; Peregrina, J.M.; Vocadlo, D.J.; Rovira, C.; Hurtado-Guerrero, R.
Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2
Angew. Chem. Int. Ed. Engl.
53
8206-8210
2014
Homo sapiens
Irazoqui, F.; Zlocowski, N.; Lorenz, V.; Bennett, E.; Clausen, H.; Nores, G.
An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2
Biol. Chem.
394
69-77
2013
Homo sapiens
Voglmeir, J.; Laurent, N.; Flitsch, S.L.; Oelgeschlaeger, M.; Wilson, I.B.
Biological and biochemical properties of two Xenopus laevis N-acetylgalactosaminyltransferases with contrasting roles in embryogenesis
Comp. Biochem. Physiol. B
180
40-47
2015
Xenopus laevis
Kong, Y.; Joshi, H.J.; Schjoldager, K.T.; Madsen, T.D.; Gerken, T.A.; Vester-Christensen, M.B.; Wandall, H.H.; Bennett, E.P.; Levery, S.B.; Vakhrushev, S.Y.; Clausen, H.
Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis
Glycobiology
25
55-65
2015
Homo sapiens
Taus, C.; Lucini, C.; Sato, T.; Furukawa, K.; Grabherr, R.; Staudacher, E.
Expression and characterization of the first snail-derived UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
Glycoconj. J.
30
825-833
2013
Biomphalaria glabrata
Taus, C.; Windwarder, M.; Altmann, F.; Grabherr, R.; Staudacher, E.
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase from the snail Biomphalaria glabrata - substrate specificity and preference of glycosylation sites
Glycoconj. J.
31
661-670
2014
Biomphalaria glabrata
Gerken, T.A.; Revoredo, L.; Thome, J.J.; Tabak, L.A.; Vester-Christensen, M.B.; Clausen, H.; Gahlay, G.K.; Jarvis, D.L.; Johnson, R.W.; Moniz, H.A.; Moremen, K.
The lectin domain of the polypeptide GalNAc transferase family of glycosyltransferases (ppGalNAc Ts) acts as a switch directing glycopeptide substrate glycosylation in an N- or C-terminal direction, further controlling mucin type O-glycosylation
J. Biol. Chem.
288
19900-19914
2013
Bos taurus, Homo sapiens
Song, L.; Bachert, C.; Schjoldager, K.T.; Clausen, H.; Linstedt, A.D.
Development of isoform-specific sensors of polypeptide GalNAc-transferase activity
J. Biol. Chem.
289
30556-30566
2014
Homo sapiens
Bhat, N.; Wojczyk, B.S.; DeCicco, M.; Castrodad, C.; Spitalnik, S.L.; Ward, H.D.
Identification of a family of four UDP-polypeptide N-acetylgalactosaminyl transferases in Cryptosporidium species
Mol. Biochem. Parasitol.
191
24-27
2013
Cryptosporidium parvum, Cryptosporidium hominis, Cryptosporidium muris
Wang, R.; Yu, C.; Zhao, D.; Wu, M.; Yang, Z.
The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13
Oncol. Rep.
30
667-676
2013
Homo sapiens
Wang, Z.Q.; Bachvarova, M.; Morin, C.; Plante, M.; Gregoire, J.; Renaud, M.C.; Sebastianelli, A.; Bachvarov, D.
Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation
Oncotarget
5
544-560
2014
Homo sapiens
Gomez, H.; Rojas, R.; Patel, D.; Tabak, L.A.; Lluch, J.M.; Masgrau, L.
A computational and experimental study of O-glycosylation. Catalysis by human UDP-GalNAc polypeptide:GalNAc transferase-T2
Org. Biomol. Chem.
12
2645-2655
2014
Homo sapiens (Q10471), Homo sapiens
Mochizuki, Y.; Ito, K.; Izumi, H.; Kohno, K.; Amano, J.
Expression of polypeptide N-acetylgalactosaminyl transferase-3 and its association with clinicopathological factors in thyroid carcinomas
Thyroid
23
1553-1560
2013
Homo sapiens (Q14435), Homo sapiens
Yao, X.; Ei-Samahy, M.A.; Feng, X.; Zhang, T.; Li, F.; Zhang, G.; Pang, J.; Nie, H.; Wang, F.
Expression and localization of polypeptide N-acetylgalactosaminyltransferase-like protein 5 in the reproductive organs and sperm of Hu sheep
Anim. Reprod. Sci.
187
159-166
2017
Ovis aries (W5PDL7)
Xu, J.; Morio, A.; Morokuma, D.; Nagata, Y.; Hino, M.; Masuda, A.; Li, Z.; Mon, H.; Kusakabe, T.; Lee, J.M.
A functional polypeptide N-acetylgalactosaminyltransferase (PGANT) initiates O-glycosylation in cultured silkworm BmN4 cells
Appl. Microbiol. Biotechnol.
102
8783-8797
2018
Bombyx mori (H9JHA7), Bombyx mori
Tang, J.; Zheng, H.; Chen, L.; Gao, S.; Shi, X.; Liu, J.; Xu, L.
Isoform-specific regulation of osteogenic factors by polypeptide N-acetylgalactosaminyltransferases 1 and 4
Biochem. Biophys. Res. Commun.
482
1449-1454
2017
Mus musculus (O08832), Mus musculus (O08912)
Yu, C.; Liang, L.; Yin, Y.
Structural basis of carbohydrate transfer activity of UDP-GalNAc Polypeptide N-acetylgalactosaminyltransferase 7
Biochem. Biophys. Res. Commun.
510
266-271
2019
Homo sapiens (Q86SF2)
Shan, A.; Lu, J.; Xu, Z.; Li, X.; Xu, Y.; Li, W.; Liu, F.; Yang, F.; Sato, T.; Narimatsu, H.; Zhang, Y.
Polypeptide N-acetylgalactosaminyltransferase 18 non-catalytically regulates the ER homeostasis and O-glycosylation
Biochim. Biophys. Acta
1863
870-882
2019
Homo sapiens (Q6P9A2)
Lackman, J.J.; Goth, C.K.; Halim, A.; Vakhrushev, S.Y.; Clausen, H.; Petaejae-Repo, U.E.
Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human delta-opioid receptor turnover at the plasma membrane
Cell. Signal.
42
184-193
2018
Homo sapiens (Q10471), Homo sapiens
Yan, X.; Lu, J.; Zou, X.; Zhang, S.; Cui, Y.; Zhou, L.; Liu, F.; Shan, A.; Lu, J.; Zheng, M.; Feng, B.; Zhang, Y.
The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation
FEBS J.
285
3041-3055
2018
Homo sapiens (Q8N4A0), Homo sapiens
Choi, J.; Wagner, L.J.S.; Timmermans, S.B.P.E.; Malaker, S.A.; Schumann, B.; Gray, M.A.; Debets, M.F.; Takashima, M.; Gehring, J.; Bertozzi, C.R.
Engineering orthogonal polypeptide GalNAc-transferase and UDP-sugar pairs
J. Am. Chem. Soc.
141
13442-13453
2019
Homo sapiens (Q10471), Homo sapiens
Xu, Y.; Pang, W.; Lu, J.; Shan, A.; Zhang, Y.
Polypeptide N-acetylgalactosaminyltransferase 13 contributes to neurogenesis via stabilizing the mucin-type O-glycoprotein podoplanin
J. Biol. Chem.
291
23477-23488
2016
Mus musculus (Q8CF93), Mus musculus
Goth, C.K.; Tuhkanen, H.E.; Khan, H.; Lackman, J.J.; Wang, S.; Narimatsu, Y.; Hansen, L.H.; Overall, C.M.; Clausen, H.; Schjoldager, K.T.; Petaejae-Repo, U.E.
Site-specific O-glycosylation by polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) co-regulates beta1-adrenergic receptor N-terminal cleavage
J. Biol. Chem.
292
4714-4726
2017
Homo sapiens (Q10471)
Hintze, J.; Ye, Z.; Narimatsu, Y.; Madsen, T.D.; Joshi, H.J.; Goth, C.K.; Linstedt, A.; Bachert, C.; Mandel, U.; Bennett, E.P.; Vakhrushev, S.Y.; Schjoldager, K.T.
Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines
J. Biol. Chem.
293
19064-19077
2018
Homo sapiens (Q10471), Homo sapiens (Q8NCW6)
Simon, E.J.; Linstedt, A.D.
Site-specific glycosylation of Ebola virus glycoprotein by human polypeptide GalNAc-transferase 1 induces cell adhesion defects
J. Biol. Chem.
293
19866-19873
2018
Homo sapiens (Q10472), Homo sapiens
Peluso, G.; Tian, E.; Abusleme, L.; Munemasa, T.; Mukaibo, T.; Ten Hagen, K.G.
Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome
J. Biol. Chem.
295
1411-1425
2020
Mus musculus (P70419)
DeCicco RePass, M.A.; Bhat, N.; Heimburg-Molinaro, J.; Bunnell, S.; Cummings, R.D.; Ward, H.D.
Molecular cloning, expression, and characterization of UDP N-acetyl-alpha-D-galactosamine Polypeptide N-acetylgalactosaminyltransferase 4 from Cryptosporidium parvum
Mol. Biochem. Parasitol.
221
56-65
2018
Cryptosporidium parvum (Q6TBQ8), Cryptosporidium parvum
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