Information on EC 2.4.1.39 - steroid N-acetylglucosaminyltransferase

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The expected taxonomic range for this enzyme is: Oryctolagus cuniculus

EC NUMBER
COMMENTARY hide
2.4.1.39
-
RECOMMENDED NAME
GeneOntology No.
steroid N-acetylglucosaminyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + estradiol-17alpha 3-D-glucuronoside = UDP + 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9033-56-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
16,17-epiestriol-3-D-glucuronoside + UDP-N-acetylglucosamine
?
show the reaction diagram
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-
-
-
?
16-epiestriol-3-D-glucuronoside + UDP-N-acetylglucosamine
UDP + 16-(N-acetyl-D-glucosaminyl)-epiestriol 3-D-glucuronoside
show the reaction diagram
-
-
-
?
17alpha-estradiol-3-D-glucuronoside + UDP-N-acetylglucosamine
UDP + 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside
show the reaction diagram
17alpha-estradiol-3-glucuronoside + UDP-N-acetylglucosamine
UDP + 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside
show the reaction diagram
-
-
-
?
additional information
?
-
-
high specificity for the 17alpha-hydroxyl group on phenolic steroids which are already attached through position 3 to glucosiduronic acid, overview
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-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
17alpha-estradiol-3-glucuronoside + UDP-N-acetylglucosamine
UDP + 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside
show the reaction diagram
-
-
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Chymotrypsin
-
-
-
diethylstilbestrol
-
-
Eugenol
-
i.e. 2-methoxy-4-(2-propenyl)phenol
Phospholipase C
-
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.168
17alpha-Estradiol-3-glucuronoside
-
-
0.0684
UDP-N-acetylglucosamine
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-10°C, half-life 25 days
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