Information on EC 2.4.1.338 - validoxylamine A glucosyltransferase

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The expected taxonomic range for this enzyme is: Streptomyces hygroscopicus

EC NUMBER
COMMENTARY hide
2.4.1.338
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RECOMMENDED NAME
GeneOntology No.
validoxylamine A glucosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucose + validoxylamine A = UDP + validamycin A
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Acarbose and validamycin biosynthesis
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Biosynthesis of antibiotics
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validamycin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
UDP-alpha-D-glucose:validoxylamine-A 4'-O-glucosyltransferase
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, catalyses the ultimate step in the biosynthesis of the antifungal agent validamycin A.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ADP-alpha-D-glucose + validoxylamine A
ADP + validamycin A
show the reaction diagram
GDP-alpha-D-glucose + validoxylamine A
GDP + validamycin A
show the reaction diagram
TDP-alpha-D-glucose + validoxylamine A
TDP + validamycin A
show the reaction diagram
UDP-alpha-D-glucose + 1,1'-bis-valienamine
UDP + validienamycin
show the reaction diagram
UDP-alpha-D-glucose + validoxylamine A
UDP + validamycin A
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-glucose + 1,1'-bis-valienamine
UDP + validienamycin
show the reaction diagram
UDP-alpha-D-glucose + validoxylamine A
UDP + validamycin A
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
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promotes enzyme activity
Fe2+
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promotes enzyme activity
Mn2+
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promotes enzyme activity
Zn2+
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promotes enzyme activity
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
His6-Tagged ValG
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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expression in Escherichia coli and Streptomyces lividans
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