Information on EC 2.4.1.328 - erythronolide mycarosyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.4.1.328
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RECOMMENDED NAME
GeneOntology No.
erythronolide mycarosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dTDP-beta-L-mycarose + erythronolide B = dTDP + 3-alpha-L-mycarosylerythronolide B
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of 12-, 14- and 16-membered macrolides
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Biosynthesis of antibiotics
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erythromycin D biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
dTDP-beta-L-mycarose:erythronolide B 3-beta-L-mycarosyltransferase
Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
enzyme catalyzes reaction of EC 2.4.1.277
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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deletion of eryBV gene results in the accumulation of 5-O-desosaminyl erythronolide B
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dTDP-beta-L-mycarose + erythronolide B
dTDP + 3-alpha-L-mycarosylerythronolide B
show the reaction diagram
dTDP-beta-L-mycarose + erythronolide B
dTDP + 3-beta-L-mycarosylerythronolide B
show the reaction diagram
additional information
?
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EryBV tolerates C5/C6 aglycon modifications and a small set of additional TDP-beta-L-sugars
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dTDP-beta-L-mycarose + erythronolide B
dTDP + 3-alpha-L-mycarosylerythronolide B
show the reaction diagram
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?
dTDP-beta-L-mycarose + erythronolide B
dTDP + 3-beta-L-mycarosylerythronolide B
show the reaction diagram
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the enzyme is involved in the erythromycin biosynthetic pathway
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r
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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no requirement for an auxiliary activator protein
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45500
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x * 45500, calculated from amino acid sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 45500, calculated from amino acid sequence
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-80°C, stable for more than three months
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Streptomyces lividans
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