Information on EC 2.4.1.316 - tylactone mycaminosyltransferase

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The expected taxonomic range for this enzyme is: Streptomyces fradiae

EC NUMBER
COMMENTARY hide
2.4.1.316
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RECOMMENDED NAME
GeneOntology No.
tylactone mycaminosyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tylactone + dTDP-alpha-D-mycaminose = dTDP + 5-O-beta-D-mycaminosyltylactone
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of 12-, 14- and 16-membered macrolides
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Biosynthesis of antibiotics
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tylosin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
dTDP-alpha-D-mycaminose:tylactone 5-O-beta-D-mycaminosyltransferase
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. Activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
tylactone + dTDP-alpha-D-mycaminose
dTDP + 5-O-beta-D-mycaminosyltylactone
show the reaction diagram
tylactone + dTDP-D-desosaminose
dTDP + 5-O-desosaminyl-tylactone
show the reaction diagram
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-
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?
tylactone + dTDP-D-mycaminose
dTDP + 5-O-beta-D-mycaminosyltylactone
show the reaction diagram
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the product of gene tylM2 is the glycosyltansferase that adds mycaminose to the 5-hydroxyl group of tylactone
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?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
tylactone + dTDP-alpha-D-mycaminose
dTDP + 5-O-beta-D-mycaminosyltylactone
show the reaction diagram
P95747
the enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin
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-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
tylM3 protein
activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
48640
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x * 48640, calculated
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 48640, calculated
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in double mutant (KdesI/KdesVII) of Streptomyces venezuelae