Disease on EC 2.4.1.255 - protein O-GlcNAc transferase
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Adenocarcinoma of Lung
High O-linked N-acetylglucosamine transferase expression predicts poor survival in patients with early stage lung adenocarcinoma.
Alzheimer Disease
Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain.
Alzheimer Disease
Early and Persistent O-GlcNAc Protein Modification in the Streptozotocin Model of Alzheimer's Disease.
Alzheimer Disease
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.
Alzheimer Disease
The mitochondrial O-linked N-acetylglucosamine transferase (mOGT) in the diabetic patient could be the initial trigger to develop Alzheimer disease.
Alzheimer Disease
UDP-N-acetylglucosaminyl transferase (OGT) in brain tissue: temperature sensitivity and subcellular distribution of cytosolic and nuclear enzyme.
Breast Neoplasms
O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes.
Carcinogenesis
Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression.
Carcinogenesis
O-linked N-acetylglucosamine transferase enhances secretory clusterin expression via liver X receptors and sterol response element binding protein regulation in cervical cancer.
Carcinogenesis
O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes.
Carcinoma
A common sugar-nucleotide-mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F-GalNAc (Ac3).
Carcinoma
Critical role of O-GlcNAc transferase in prostate cancer invasion, angiogenesis and metastasis.
Carcinoma
MicroRNAs MiR-15a and MiR-26a cooperatively regulate O-GlcNAc-transferase to control proliferation in clear cell renal cell carcinoma.
Carcinoma
O-GlcNAcylation is associated with the development and progression of gastric carcinoma.
Carcinoma
O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma.
Carcinoma, Hepatocellular
O-GlcNAc transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E.
Carcinoma, Renal Cell
MicroRNAs MiR-15a and MiR-26a cooperatively regulate O-GlcNAc-transferase to control proliferation in clear cell renal cell carcinoma.
Cardiovascular Diseases
Shaken, not stirred: bioanalytical study of the antioxidant activities of martinis.
Cataract
Shaken, not stirred: bioanalytical study of the antioxidant activities of martinis.
Cholangiocarcinoma
Overexpression of O-GlcNAc-Transferase Associates with Aggressiveness of Mass-Forming Cholangiocarcinoma.
Colorectal Neoplasms
Identification of an HLA-A0201-restricted CTL epitope generated by a tumor-specific frameshift mutation in a coding microsatellite of the OGT gene.
Diabetes Complications
Increased OGA Expression and Activity in Leukocytes from Patients with Diabetes: Correlation with Inflammation Markers.
Diabetes Complications
Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications.
Diabetes Mellitus
O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats.
Diabetic Nephropathies
O-linked N-acetylglucosaminyltransferase OGT inhibits diabetic nephropathy by stabilizing histone methyltransferases EZH2 via the HES1/PTEN axis.
Esophageal Neoplasms
Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells.
Esophageal Neoplasms
MiRNA-485-5p, inhibits esophageal cancer cells proliferation and invasion by down-regulating O-linked N-acetylglucosamine transferase.
Esophageal Squamous Cell Carcinoma
O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma.
Hepatitis C
Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity.
Herpes Simplex
Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus.
Infections
Human metapneumovirus infection of airway epithelial cells is associated with changes in core metabolic pathways.
Infections
SECRET AGENT, an Arabidopsis thaliana O-GlcNAc transferase, modifies the Plum pox virus capsid protein.
Insulin Resistance
Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia.
Insulin Resistance
Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles.
Insulin Resistance
Functional expression of O-linked GlcNAc transferase. Domain structure and substrate specificity.
Insulin Resistance
Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications.
Insulin Resistance
O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes.
Insulin Resistance
Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes.
Intellectual Disability
Disease related single point mutations alter the global dynamics of a tetratricopeptide (TPR) ?-solenoid domain.
Liver Neoplasms
Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells.
Lymphatic Metastasis
Cyclin Y regulates the proliferation, migration, and invasion of ovarian cancer cells via Wnt signaling pathway.
Malaria
Studies on O-glycans of Plasmodium-falciparum-infected human erythrocytes. Evidence for O-GlcNAc and O-GlcNAc-transferase in malaria parasites.
Neoplasm Metastasis
Cyclin Y regulates the proliferation, migration, and invasion of ovarian cancer cells via Wnt signaling pathway.
Neoplasm Metastasis
OGT regulated O-GlcNAcylation promotes papillary thyroid cancer malignancy via activating YAP.
Neoplasms
Cyclin Y regulates the proliferation, migration, and invasion of ovarian cancer cells via Wnt signaling pathway.
Neoplasms
Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression.
Neoplasms
Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding.
Neoplasms
O-GlcNAc protein modification in cancer cells increases in response to glucose deprivation through glycogen degradation.
Neoplasms
O-GlcNAcylation is associated with the development and progression of gastric carcinoma.
Neoplasms
O-Linked N-Acetylglucosamine (O-GlcNAc) Expression Levels Epigenetically Regulate Colon Cancer Tumorigenesis by Affecting the Cancer Stem Cell Compartment via Modulating Expression of Transcriptional Factor MYBL1.
Neoplasms
O-linked N-acetylglucosamine transferase enhances secretory clusterin expression via liver X receptors and sterol response element binding protein regulation in cervical cancer.
Neoplasms
OGT regulated O-GlcNAcylation promotes papillary thyroid cancer malignancy via activating YAP.
Neuroblastoma
A?-affected pathogenic induction of S-nitrosylation of OGT and identification of Cys-NO linkage triplet.
Neurodegenerative Diseases
Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain.
Neurodegenerative Diseases
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).
Neurodegenerative Diseases
Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates.
Osteosarcoma
Relationship Between O-GlcNAcase Expression and Prognosis of Patients With Osteosarcoma.
Prostatic Neoplasms
Critical role of O-GlcNAc transferase in prostate cancer invasion, angiogenesis and metastasis.
Renal Insufficiency
Silencing of O-linked N-acetylglucosamine transferase ameliorates hypercalcemia-induced neurotoxicity in renal failure by regulating EZH2/KLF2/CXCL1 axis.
Starvation
ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation.
Stomach Neoplasms
Silencing ?-linked N-acetylglucosamine transferase induces apoptosis in human gastric cancer cells through PUMA and caspase-3 pathways.
Thyroid Cancer, Papillary
OGT regulated O-GlcNAcylation promotes papillary thyroid cancer malignancy via activating YAP.
Uterine Cervical Neoplasms
O-linked N-acetylglucosamine transferase enhances secretory clusterin expression via liver X receptors and sterol response element binding protein regulation in cervical cancer.
Uterine Cervical Neoplasms
O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes.
Virus Diseases
Identification of secret agent as the O-GlcNAc transferase that participates in Plum pox virus infection.
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