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Disease on EC 2.4.1.22 - lactose synthase

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DISEASE
TITLE OF PUBLICATION
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Adenocarcinoma
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Interactions of cell-surface galactosyltransferase with immunoglobulins.
Adenocarcinoma of Lung
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.
Adenocarcinoma, Mucinous
Mucinous carcinoma of the eyelid. An immunohistochemical study.
Adenoma
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Adenoma, Pleomorphic
Cell-surface galactosyltransferase acts as a modulator of rat and human acinar cell proliferation.
Alopecia
Anti-alopecia effect of Gly-Leu-Phe, an immunostimulating peptide derived from alpha-lactalbumin.
Anaphylaxis
Goats' milk of defective alpha(s1)-casein genotype decreases intestinal and systemic sensitization to beta-lactoglobulin in guinea pigs.
Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer's patches.
Successful management of severe cow's milk allergy with omalizumab treatment and CD-sens monitoring.
Anemia
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial.
Proteins selectively killing tumor cells.
Anemia, Iron-Deficiency
Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial.
Argininosuccinic Aciduria
Impaired development of mammary glands in scorbutic rats unable to synthesize ascorbic acid.
Arthritis, Rheumatoid
Agalactosyl IgG and beta-1,4-galactosyltransferase gene expression in rheumatoid arthritis patients and in the arthritis-prone MRL lpr/lpr mouse.
Serum galactosyltransferase isoform changes in rheumatoid arthritis.
Asthma
Study of IgG sub-class antibodies in patients with milk intolerance.
Asthma, Occupational
Occupational asthma and rhinoconjunctivitis from inhalation of dried cow's milk caused by sensitization to alpha-lactalbumin.
Asymptomatic Infections
Gene expression of factors related to the immune reaction in response to intramammary Escherichia coli lipopolysaccharide challenge.
Autoimmune Diseases
Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes.
Breast Cyst
Presence of alpha-lactalbumin, epidermal growth factor, epithelial membrane antigen, and gross cystic disease fluid protein (15,000 daltons) in breast cyst fluid.
Breast Diseases
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Breast Neoplasms
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Alpha-lactalbumin and GCDFP-15 as breast tumor markers (an opportunity to study breast tumors functionally).
Alpha-lactalbumin as an immunohistochemical marker for metastatic breast carcinomas.
alpha-Lactalbumin in human and subhuman primate normal mammary tissue and in human breast cancer as a marker for prolactin activity.
alpha-Lactalbumin is not a marker of human hormone-dependent breast cancer.
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Alpha-lactalbumin production in human mammary carcinoma.
An autoimmune-mediated strategy for prophylactic breast cancer vaccination.
Breast cancer vaccines delivered by dendritic cell-targeted lentivectors induce potent antitumor immune responses and protect mice from mammary tumor growth.
Casein and alpha-lactalbumin detection in breast cancer cells by immunocytochemistry.
Casein and alpha-lactalbumin messenger RNA in experimental breast cancer.
Complex biochemical analysis of human breast tumor tissue.
Comprehensive N-glycome profiling of cultured human epithelial breast cells identifies unique secretome N-glycosylation signatures enabling tumorigenic subtype classification.
Conversion of the amphiphilic galactosyltransferase from human mammary carcinoma cells to an active hydrophilic enzyme form by limited proteolysis.
Detection of alpha-lactalbumin in breast lesions and relationship to estrogen receptors and serum prolactin.
Discrimination by RT-Nested PCR of Alpha-Lactalbumin Transcript Expression in Mammary Tumors.
Expression of LacdiNAc groups on N-glycans among human tumors is complex.
Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin.
Human alpha-lactalbumin: measurement in serum and in breast cancer organ cultures by radioimmunoassay.
Immunohistochemical localization of alpha-lactalbumin in human breast cancer tissue.
Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.
Opposite effects of estrogen and catecholestrogen on hormone-sensitive breast cancer cell growth and differentiation.
Production and characterization of murine monoclonal antibody to human alpha-lactalbumin.
Prognostic significance of immunohistochemical parameters in breast carcinomas.
Serum human alpha-lactalbumin as a marker for breast cancer.
Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer.
Tissue-specific promoters active in CD44+CD24-/low breast cancer cells.
Transcriptional targeting modalities in breast cancer gene therapy using adenovirus vectors controlled by alpha-lactalbumin promoter.
[Immunohistochemistry of alpha-lactalbumin, lactoferrin and trans- ferrin receptor in invasive breast carcinomas with regard to tumor grading, estrogen receptor status and tumor staging]
Carcinoma
alpha-Lactalbumin content of rat mammary carcinomas and the effect of pituitary stimulation.
Alpha-lactalbumin in "common" epithelial tumors of the ovary. An immunohistochemical study.
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Alpha-lactalbumin production in human mammary carcinoma.
Alteration in the metastatic potential of ovarian cancer cells by transfection of the antisense gene of beta-1,4-galactosyltransferase.
An enzyme-linked immunosorbent assay for lactose synthase (galactosyltransferase) in serum and its application as a tumor marker in ovarian carcinoma.
Beta-1,4-galactosyltransferase II predicts poor prognosis of patients with non-metastatic clear-cell renal cell carcinoma.
Breast carcinoma in patients receiving neuroleptic therapy. Morphologic and clinicopathologic features of thirteen cases.
Conversion of the amphiphilic galactosyltransferase from human mammary carcinoma cells to an active hydrophilic enzyme form by limited proteolysis.
Detection of alpha-lactalbumin in breast lesions and relationship to estrogen receptors and serum prolactin.
Eccrine sweat gland carcinoma: an histologic and immunohistochemical study of 32 cases.
Endogenous oligonucleotides of human milk and their possible biological function.
Hormonal stimulation of lactose synthetase in mammary carcinoma.
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Mammary Paget's disease and associated carcinoma. An immunohistochemical study.
N-Glycosylation of total cellular glycoproteins from the human ovarian carcinoma SKOV3 cell line and of recombinantly expressed human erythropoietin.
Primary adenoid cystic carcinoma of the skin. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma.
Priming mass spectrometry-based sulfoglycomic mapping for identification of terminal sulfated lacdiNAc glycotope.
Recurrent secretory carcinoma in residual mammary tissue after mastectomy.
Secretory carcinoma coexistent with mucinous carcinoma in the breast. Report of a case.
Secretory carcinoma of the breast: light microscopical, immunohistochemical and flow cytometric study.
Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer.
Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast.
Carcinoma, Adenoid Cystic
Primary adenoid cystic carcinoma of the skin. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma.
Carcinoma, Ductal
Detection of alpha-lactalbumin in breast lesions and relationship to estrogen receptors and serum prolactin.
Carcinoma, Embryonal
Cell surface and Golgi pools of beta-1,4-galactosyltransferase are differentially regulated during embryonal carcinoma cell differentiation.
Molecular cloning and characterization of beta-1,4-galactosyltransferase expressed in mouse testis.
Uvomorulin, LAMP-1, and laminin are substrates for cell surface beta-1,4-galactosyltransferase on F9 embryonal carcinoma cells: comparisons between wild-type and mutant 5.51 att- cells.
Carcinoma, Hepatocellular
Effect of all-trans-retinoic acid and phorbol 12-myristate 13-acetate on the activity of human hepatocellular carcinoma cell-surface beta-1,4-galactosyltransferase.
Interactions of cell-surface galactosyltransferase with immunoglobulins.
The chicken genome contains two functional nonallelic beta1,4-galactosyltransferase genes. Chromosomal assignment to syntenic regions tracks fate of the two gene lineages in the human genome.
Carcinoma, Intraductal, Noninfiltrating
Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer.
Carcinoma, Lobular
Invasive lobular carcinoma of the breast. An analysis of 29 cases.
Carcinoma, Ovarian Epithelial
Correlation of UDP-galactose glycoprotein:galactosyltransferase levels in the sera with the clinical status of ovarian cancer patients.
Carcinoma, Renal Cell
Beta-1,4-galactosyltransferase II predicts poor prognosis of patients with non-metastatic clear-cell renal cell carcinoma.
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Celiac Disease
Gut permeability to human alpha-lactalbumin, beta-lactoglobulin, mannitol, and lactulose in celiac disease.
Influence of cow's milk proteins and gluten on human duodenal mucosa in organ culture.
Cholera
Cyclic AMP as a negative regulator of hormonally induced lactogenesis in mouse mammary gland organ culture.
Pituitary-induced lactation in mammary gland explants from the pregnant tammar (Macropus eugenii): a negative role for cyclic AMP.
Choriocarcinoma
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.
Colic
Macromolecular absorption in infants with infantile colic.
Colitis, Ulcerative
Serum antibodies to cow's milk proteins in pediatric inflammatory bowel disease: Crohn's disease vs. ulcerative colitis.
Serum antibodies to cow's milk proteins in ulcerative colitis and Crohn's disease.
The effect of proctocolectomy on serum antibody levels against cow's milk proteins in patients with chronic ulcerative colitis, with special reference to liver changes.
Colonic Neoplasms
Growth rates of a human colon adenocarcinoma cell line are regulated by the milk protein alpha-lactalbumin.
Colorectal Neoplasms
?1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells.
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
Diagnostic and Prognostic Value of B4GALT1 Hypermethylation and Its Clinical Significance as a Novel Circulating Cell-Free DNA Biomarker in Colorectal Cancer.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
B4GALT1-congenital disorders of glycosylation: Expansion of the phenotypic and molecular spectrum and review of the literature.
Crohn Disease
Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes.
Serum antibodies to cow's milk proteins in pediatric inflammatory bowel disease: Crohn's disease vs. ulcerative colitis.
Serum antibodies to cow's milk proteins in ulcerative colitis and Crohn's disease.
Cystadenoma
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Cysts
Presence of alpha-lactalbumin, epidermal growth factor, epithelial membrane antigen, and gross cystic disease fluid protein (15,000 daltons) in breast cyst fluid.
Dementia, Vascular
Construction of a ceRNA immunoregulatory network related to the development of vascular dementia through a weighted gene coexpression network analysis.
Dermatitis, Atopic
Occurrence and subclass distribution of IgG antibodies to dietary antigens in children with atopic dermatitis and in their mothers.
Specific humoral response to cows' milk proteins and ovalbumin in children with atopic dermatitis.
Diabetes Mellitus, Type 1
Circulating antibodies to common food antigens in Japanese children with IDDM.
Diabetes Mellitus, Type 2
Experts' opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond.
Eczema
Study of IgG sub-class antibodies in patients with milk intolerance.
Endometrial Neoplasms
Changes of beta-1,4-galactosyltransferase with the development of endometrial cancer.
Endometriosis
Differentially expressed gene profiles in the serum before and after the ultrasound-guided ethanol sclerotherapy in patients with ovarian endometriomas.
Galactorrhea
Composition of breast fluid of a man with galactorrhea and hyperprolactinaemia.
Gastroenteritis
Increased protein absorption after acute gastroenteritis in children.
Glaucoma, Open-Angle
Identification of Mutations in Myocilin and Beta-1,4-galactosyltransferase 3 Genes in a Chinese Family with Primary Open-angle Glaucoma.
Glioblastoma
B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo.
Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
Glomerulonephritis, IGA
Development of immunoglobulin A nephropathy- like disease in beta-1,4-galactosyltransferase-I-deficient mice.
Glomerulonephritis, Membranoproliferative
Mucosal immunity in primary glomerulonephritis: II. Study of the serum IgA subclass repertoire to food and airborne antigens.
Granuloma
LacdiNAc- and LacNAc-containing glycans induce granulomas in an in vivo model for schistosome egg-induced hepatic granuloma formation.
Gynecomastia
Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer.
Hepatitis B
Mechanism of adsorption of three recombinant Streptococcus pneumoniae (Sp) vaccine antigens by an aluminum adjuvant.
Herpes Simplex
Antiviral activity of esterified alpha-lactalbumin and beta-lactoglobulin against herpes simplex virus type 1. Comparison with the effect of acyclovir and L-polylysines.
Herpes Zoster
A role for mouse sperm surface galactosyltransferase in sperm binding to the egg zona pellucida.
Aggregation of beta-1,4-galactosyltransferase on mouse sperm induces the acrosome reaction.
Beta-1,4-galactosyltransferase expression during spermatogenesis: stage-specific regulation by t alleles and uniform distribution in + -spermatids and t-spermatids.
Can relative spermatozoal galactosyltransferase activity be predictive of dairy bull fertility?
Distribution and dynamics of mouse sperm surface galactosyltransferase: implications for mammalian fertilization.
Effects of bovine mammary alpha-lactalbumin on hyperactivation and sperm-zona pellucida binding of mouse spermatozoa.
Relationship between two types of mouse sperm surface sites that mediate binding of sperm to the zona pellucida.
Sperm from a variety of mammalian species express beta1,4-galactosyltransferase on their surface.
Hyperprolactinemia
Composition of breast fluid of a man with galactorrhea and hyperprolactinaemia.
Hypersensitivity
A hydrolysed rice-based formula is tolerated by children with cow's milk allergy: a multi-centre study.
Allergy to the heat-labile proteins alpha-lactalbumin and beta-lactoglobulin in mare's milk.
B-cell epitopes as a screening instrument for persistent cow's milk allergy.
Challenge testing in children with allergy to cow's milk proteins.
Human IgE binding capacity of tryptic peptides from bovine alpha-lactalbumin.
Immune reactivity of cow-asthmatic dairy farmers to the major allergen of cow (BDA20) and to other cow-derived proteins. The use of purified BDA20 increases the performance of diagnostic tests in respiratory cow allergy.
Value of IgG4 antibodies against foods in atopic dermatitis.
Visualization of clustered IgE epitopes on alpha-lactalbumin.
Hypopituitarism
Targeted mutation in beta1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality.
Infections
Effect of bovine somatotropin on neutrophil functions and clinical symptoms during Streptococcus uberis mastitis.
LacdiNAc- and LacNAc-containing glycans induce granulomas in an in vivo model for schistosome egg-induced hepatic granuloma formation.
Mammalian glycosyltransferase expression allows sialoglycoprotein production by baculovirus-infected insect cells.
Novel baculovirus expression vectors that provide sialylation of recombinant glycoproteins in lepidopteran insect cells.
Physiological and pathological factors influencing bovine alpha-lactalbumin and beta-lactoglobulin concentrations in milk.
Proteomic analysis of the temporal expression of bovine milk proteins during coliform mastitis and label-free relative quantification.
Inflammatory Bowel Diseases
Serum antibodies to cow's milk proteins in pediatric inflammatory bowel disease: Crohn's disease vs. ulcerative colitis.
lactose synthase deficiency
Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice.
Leukemia
B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.
B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin-resistant cell line.
LacdiNAc (GalNAc?1-4GlcNAc) Contributes to Self-Renewal of Mouse Embryonic Stem Cells by Regulating Leukemia Inhibitory Factor/STAT3 Signaling.
Measurement of beta-galactosyltransferase activity in cell extracts with an ELISA-based assay.
Molecular basis for recognition of the cancer glycobiomarker LacdiNAc (GalNAc(?1-4)GlcNAc) by Wisteria floribunda agglutinin.
Leukemia, Myeloid, Acute
[Effect of B4GALT1 on Proliferation of Its Co-cultured Human Acute Myeloid Leukemia Cell Line in Bone Marrow Stromal Cells].
Liver Diseases
Increased serum antibody levels against cow's milk proteins in children with chronic liver disease.
Liver Neoplasms
Molecular basis for recognition of the cancer glycobiomarker LacdiNAc (GalNAc(?1-4)GlcNAc) by Wisteria floribunda agglutinin.
Lung Neoplasms
B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem Cells.
Isolation and characterization of cancer-associated galactosyltransferase isoenzyme.
Lupus Erythematosus, Systemic
Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes.
Lymphatic Metastasis
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Lymphoma
Human ovarian cancer, lymphoma spleen, and bovine milk GlcNAc:beta1,4Gal/GalNAc transferases: two molecular species in ovarian tumor and induction of GalNAcbeta1,4Glc synthesis by alpha-lactalbumin.
Inhibition of lactogenic activities of ovine prolactin and human growth hormone (hGH) by a novel form of a modified recombinant hGH.
Mastitis
Changes in lactoferrin, immunoglobulin G, bovine serum albumin, and alpha-lactalbumin during acute experimental and natural coliform mastitis in cows.
Pathology of Staphylococcus aureus mastitis during lactogenesis: relationships with bovine mammary structure and function.
Protein composition of whey from subclinical mastitis and effect of treatment with levamisole.
Melanoma
Functionally distinct laminin receptors mediate cell adhesion and spreading: the requirement for surface galactosyltransferase in cell spreading.
Proteins selectively killing tumor cells.
Milk Hypersensitivity
Allergy to the heat-labile proteins alpha-lactalbumin and beta-lactoglobulin in mare's milk.
B-cell epitopes as a screening instrument for persistent cow's milk allergy.
Challenge testing in children with allergy to cow's milk proteins.
Effect of extensively hydrolyzed milk formula on growth and resistance to bronchitis and atopic dermatitis in infants and toddlers.
Human IgE binding capacity of tryptic peptides from bovine alpha-lactalbumin.
IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow's milk allergy.
Macromolecular absorption and cows' milk allergy.
Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer's patches.
Structure and function of proteins involved in milk allergies.
Successful management of severe cow's milk allergy with omalizumab treatment and CD-sens monitoring.
[Specific IgE antibodies to cow's milk and individual cow's milk proteins in children with suspected allergy to cow's milk]
Myalgia
Effects of Alpha-Lactalbumin or Whey Protein Isolate on Muscle Damage, Muscle Pain, and Mood States Following Prolonged Strenuous Endurance Exercise.
The effect of carbohydrate and protein co-ingestion on energy substrate metabolism, sense of effort, and affective responses during prolonged strenuous endurance exercise.
Myocardial Infarction
Expression profiles of long noncoding RNAs and messenger RNAs in the border zone of myocardial infarction in rats.
Neoplasm Metastasis
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
Diagnostic and Prognostic Value of B4GALT1 Hypermethylation and Its Clinical Significance as a Novel Circulating Cell-Free DNA Biomarker in Colorectal Cancer.
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Identification of a novel glycolysis-related gene signature for predicting metastasis and survival in patients with lung adenocarcinoma.
Neoplasms
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria.
A non-competitive enzyme immunoassay of human alpha-lactalbumin in biological fluids and tissue extracts.
Aberrant genes promoter methylation in neural crest-derived tumors.
Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors.
alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids.
Alpha-lactalbumin in "common" epithelial tumors of the ovary. An immunohistochemical study.
alpha-Lactalbumin is not a marker of human hormone-dependent breast cancer.
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
alpha-Lactalbumin species variation, HAMLET formation, and tumor cell death.
Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
alpha-Lactalbumin, Engineered to be Nonnative and Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A New Biological Function Resulting from Partial Unfolding.
Alteration in the metastatic potential of ovarian cancer cells by transfection of the antisense gene of beta-1,4-galactosyltransferase.
An autoimmune-mediated strategy for prophylactic breast cancer vaccination.
An enzyme-linked immunosorbent assay for lactose synthase (galactosyltransferase) in serum and its application as a tumor marker in ovarian carcinoma.
Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Apoptosis-Like Death in Bacteria Induced by HAMLET, a Human Milk Lipid-Protein Complex.
Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin.
Augmenting the cytotoxicity of oleic acid-protein complexes: Potential of target-specific antibodies.
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo.
BAMLET activates a lysosomal cell death program in cancer cells.
Behaviour of oleic acid-depleted bovine alpha-lactalbumin made LEthal to tumor cells (BAMLET).
Beta-1,4-galactosyltransferase II predicts poor prognosis of patients with non-metastatic clear-cell renal cell carcinoma.
Beta-sheet-specific interactions with heat shock proteins define a mechanism of delayed tumor cell death in response to HAMLET.
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex.
Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Breastfeeding and its relationship with reduction of breast cancer: a review.
Can misfolded proteins be beneficial? The HAMLET case.
Carcinoembryonic antigen and alpha-lactalbumin in phylloid tumor tissues.
Casein and alpha-lactalbumin detection in breast cancer cells by immunocytochemistry.
Characterization and immunoassay of human tumor-associated galactosyltransferase isoenzyme II.
Compact oleic acid in HAMLET.
Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis.
Conversion of alpha-lactalbumin to a protein inducing apoptosis.
Conversion of human alpha-lactalbumin to an apo-like state in the complexes with basic poly-amino acids: toward understanding of the molecular mechanism of antitumor action of HAMLET.
Correlation of UDP-galactose glycoprotein:galactosyltransferase levels in the sera with the clinical status of ovarian cancer patients.
Cystic hypersecretory duct carcinoma of the breast.
Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells.
Desmoplastic trichilemmoma.
Detection of alpha-lactalbumin in breast lesions and relationship to estrogen receptors and serum prolactin.
Discrimination by RT-Nested PCR of Alpha-Lactalbumin Transcript Expression in Mammary Tumors.
Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer.
Eccrine sweat gland carcinoma: an histologic and immunohistochemical study of 32 cases.
Effect of denaturation of alpha-lactalbumin on the formation of BAMLET (bovine alpha-lactalbumin made lethal to tumor cells).
Effect of estradiol and prolactin on galactosyltransferase and alpha-lactalbumin activities in rat mammary gland and mammary tumor.
Effects of hormones on growth and alpha-lactalbumin activity in the transplantable rat mammary tumor MCCLX.
Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice.
Enhanced expression of the ?4-N-acetylgalactosaminyltransferase 4 gene impairs tumor growth of human breast cancer cells.
Expression of LacdiNAc groups on N-glycans among human tumors is complex.
Galactosyltransferase associated with tumor in patients with ovarian cancer: factors involved in elevation of serum galactosyltransferase.
Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11p110.
Glycogen-rich clear cell carcinoma of the breast. An autopsy case.
Glycogen-rich clear cell carcinoma of the breast: a solid variant with mucus. A light microscopic, immunohistochemical and ultrastructural study of a case.
Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin.
Growth rates of a human colon adenocarcinoma cell line are regulated by the milk protein alpha-lactalbumin.
HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.
HAMLET - A protein-lipid complex with broad tumoricidal activity.
HAMLET Binding to ?-Actinin Facilitates Tumor Cell Detachment.
HAMLET interacts with lipid membranes and perturbs their structure and integrity.
HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.
HAMLET kills tumor cells by apoptosis: structure, cellular mechanisms, and therapy.
HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.
Heat-treatment method for producing fatty acid-bound alpha-lactalbumin that induces tumor cell death.
High affinity oestradiol receptors and the activity of glucose-6-phosphate dehydrogenase and lactose synthetase in mammary carcinomata of postmenopausal women.
Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.
Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
Human alpha-lactalbumin: measurement in serum and in breast cancer organ cultures by radioimmunoassay.
Human ovarian cancer, lymphoma spleen, and bovine milk GlcNAc:beta1,4Gal/GalNAc transferases: two molecular species in ovarian tumor and induction of GalNAcbeta1,4Glc synthesis by alpha-lactalbumin.
Immunohistochemical localization of alpha-lactalbumin in human breast cancer tissue.
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
Innate immunity and human milk.
Interaction of antitumor alpha-lactalbumin-oleic acid complexes with artificial and natural membranes.
Invasive lobular carcinoma of the breast. An analysis of 29 cases.
Isoenzymatic patterns of human galactosyltransferase from normal and cancer patients.
Isolation and characterization of alpha-lactalbumin from a rat mammary tumor.
Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).
Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity.
Measurement of alpha-lactalbumin in serum and mammary tumors of rats by radioimmunoassay.
Molecular basis for recognition of the cancer glycobiomarker LacdiNAc (GalNAc(?1-4)GlcNAc) by Wisteria floribunda agglutinin.
Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells.
Multifaceted roles of 5'-regulatory region of the cancer associated gene B4GALT1 and its comparison with the gene family.
Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei.
No need to be HAMLET or BAMLET to interact with histones: binding of monomeric alpha-lactalbumin to histones and basic poly-amino acids.
Oleic acid complex of bovine ?-lactalbumin induces eryptosis in human and other erythrocytes by a Ca(2+)-independent mechanism.
Oleic acid-embedded nanoliposome as a selective tumoricidal agent.
POFUT1 mRNA expression as an independent prognostic parameter in muscle-invasive bladder cancer.
Protein oligomerization induced by oleic acid at the solid-liquid interface--equine lysozyme cytotoxic complexes.
Protein receptor-independent plasma membrane remodeling by HAMLET: a tumoricidal protein-lipid complex.
Protein-coding capacities of polyadenylated RNAs from normal and neoplastic rat mammary tissues.
Proteins selectively killing tumor cells.
Sample handling of gastric tissue and O-glycan alterations in paired gastric cancer and non-tumorigenic tissues.
Secretory carcinoma of the breast.
Secretory carcinoma of the breast: light microscopical, immunohistochemical and flow cytometric study.
Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET.
Separation and characterization of the neoplastic and stromal elements of the R3230AC mammary adenocarcinoma.
Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells.
Serum human alpha-lactalbumin as a marker for breast cancer.
Small-angle X-ray scattering of BAMLET at pH 12: A complex of ?-lactalbumin and oleic acid.
Stability of HAMLET--a kinetically trapped alpha-lactalbumin oleic acid complex.
Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins.
Structure and expression of the guinea-pig alpha-lactalbumin gene.
Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer.
Targeting of nucleotide-binding proteins by HAMLET-a conserved tumor cell death mechanism.
The AKR1C3/AR-V7 complex maintains CRPC tumour growth by repressing B4GALT1 expression.
The effect of mouse mammary tumor virus receptor activation on mammary epithelial cell sensitivity toward prolactin.
The interaction of equine lysozyme:oleic acid complexes with lipid membranes suggests a cargo off-loading mechanism.
The Molecular Motor F-ATP Synthase Is Targeted by the Tumoricidal Protein HAMLET.
The oleic acid complexes of proteolytic fragments of alpha-lactalbumin display apoptotic activity.
The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures.
The toxicity of BAMLET is highly dependent on oleic acid and induces killing in cancer cell lines and non-cancer derived primary cells.
Thyroid metastases from a ductal carcinoma of the breast. A case report.
Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1.
Transcriptional targeting modalities in breast cancer gene therapy using adenovirus vectors controlled by alpha-lactalbumin promoter.
Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid.
Tumor-associated antigens in breast carcinomas. Prognostic significance.
Use and relevance of a bovine mammary gland explant model to study infection responses in bovine mammary tissue.
Whey protein in cancer therapy: A narrative review.
Who is Mr. HAMLET? Interaction of human alpha-lactalbumin with monomeric oleic acid.
Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer.
[Antigenic structure of normal and malignant breast tissue]
[Immunohistochemistry of alpha-lactalbumin, lactoferrin and trans- ferrin receptor in invasive breast carcinomas with regard to tumor grading, estrogen receptor status and tumor staging]
[Quantitative immunoenzyme determination of the lactoferrin and alpha-lactalbumin in the blood serum of cancer patients]
[Value and prognostic significance of alpha-lactalbumin (ALA), lactoferrin (Lfr) and HMFG-2 in primary breast cancers. An immunohistochemical study]
Ovarian Neoplasms
Alteration in isoenzyme patterns of serum galactosyltransferase activity in ovarian cancer patients: preliminary results.
Alteration in the metastatic potential of ovarian cancer cells by transfection of the antisense gene of beta-1,4-galactosyltransferase.
Evaluation of beta1,4-galactosyltransferase as a potential biomarker for the detection of subclinical disease after the completion of primary therapy for ovarian cancer.
Human ovarian cancer, lymphoma spleen, and bovine milk GlcNAc:beta1,4Gal/GalNAc transferases: two molecular species in ovarian tumor and induction of GalNAcbeta1,4Glc synthesis by alpha-lactalbumin.
Paget's Disease, Mammary
Alpha-lactalbumin as an immunohistochemical marker for metastatic breast carcinomas.
Pancreatic Neoplasms
Expression of LacdiNAc groups on N-glycans among human tumors is complex.
Papilloma
Desmoplastic trichilemmoma.
Structure and expression of the guinea-pig alpha-lactalbumin gene.
Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid.
Phyllodes Tumor
Carcinoembryonic antigen and alpha-lactalbumin in phylloid tumor tissues.
Pleural Effusion
alpha-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines.
Isolation and characterization of cancer-associated galactosyltransferase isoenzyme.
Tissue-specific promoters active in CD44+CD24-/low breast cancer cells.
Prostatic Neoplasms
Detection of N,N-diacetyllactosamine (LacdiNAc) containing free prostate-specific antigen for early stage prostate cancer diagnostics and for identification of castration-resistant prostate cancer patients.
Glycosylation: Rising Potential for Prostate Cancer Evaluation.
Identification of Multisialylated LacdiNAc Structures as Highly Prostate Cancer Specific Glycan Signatures on PSA.
Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer.
Prostatitis
Detection of N,N-diacetyllactosamine (LacdiNAc) containing free prostate-specific antigen for early stage prostate cancer diagnostics and for identification of castration-resistant prostate cancer patients.
Retinoblastoma
Comparative gene mapping of lactoperoxidase, retinoblastoma, and alpha-lactalbumin genes in cattle, sheep, and goats.
Rickets, Hypophosphatemic
Hypersensitivity reaction in an infant fed hydrolyzed lactalbumin contained in a semielemental formula.
Rotavirus Infections
Antirotaviral activity of milk proteins: lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29.
Sarcoma
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
Starvation
Nutritional regulation of milk protein messenger RNA concentrations in mammary acini isolated from lactating rats.
Stomach Ulcer
Bovine alpha-lactalbumin stimulates mucus metabolism in gastric mucosa.
Urinary Bladder Neoplasms
B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients.
Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells).