Reference on EC 2.4.1.212 - hyaluronan synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
DeAngelis, P.L.; Papaconstantinou, J.; Weigel, P.H.
Molecular cloning, identification and sequence of the hyaluronan synthase gene from Group A Streptococcus pyogenes
J. Biol. Chem.
268
19181-19184
1993
Streptococcus pyogenes
DeAngelis, P.L.; Weigel, P.H.
Immunochemical confirmation of the primary structure of streptococcal hyaluronan synthase and synthesis of high molecular weight product by the recombinant enzyme
Biochemistry
33
9033-9039
1994
Streptococcus pyogenes
Spicer, A.P.; Augustine, M.L.; McDonald, J.A.
Molecular cloning and characterization of a putative mouse hyaluronan synthase
J. Biol. Chem.
271
23400-23406
1996
Mus musculus (P70312), Mus musculus
Kumari, K.; Weigel, P.H.
Molecular cloning, expression, and characterization of the authentic hyaluronan synthase from group C Streptococcus equisimilis
J. Biol. Chem.
272
32539-32546
1997
Streptococcus dysgalactiae subsp. equisimilis
DeAngelis, P.L.; Jing, W.; Graves, M.V.; Burbank, D.E.; Van Etten, J.L.
Hyaluronan synthase of chlorella virus PBCV-1
Science
278
1800-1803
1997
Paramecium bursaria Chlorella virus 1
Itano, N.; Sawai, T.; Yoshida, M.; Lenas, P.; Yamada, Y.; Imagawa, M.; Shinomura, T.; Hamaguchi, M.; Yoshida, Y.; Ohnuki, Y.; Miyauchi, S.; Spicer, A.P.; McDonald, J.A.; Kimata, K.
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties
J. Biol. Chem.
274
25085-25092
1999
Mus musculus
Pummill, P.E.; Achyuthan, A.M.; DeAngelis, P.L.
Enzymological characterization of recombinant Xenopus DG42, a vertebrate hyaluronan synthase
J. Biol. Chem.
273
4976-4981
1998
Xenopus laevis, Xenopus laevis protein DG42
Tlapak-Simmons, V.L.; Baggenstoss, B.A.; Clyne, T.; Weigel, P.H.
Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis
J. Biol. Chem.
274
4239-4245
1999
Streptococcus dysgalactiae subsp. equisimilis, Streptococcus pyogenes
DeAngelis, P.L.
Molecular directionality of polysaccharide polymerization by the Pasteurella multocida hyaluronan synthase
J. Biol. Chem.
274
26557-26562
1999
Pasteurella multocida (Q7BLV3), Pasteurella multocida
Jing, W.; DeAngelis, P.L.
Dissection of the two transferase activities of the Pasteurella multocida hyaluronan synthase: two active sites exist in one polypeptide
Glycobiology
10
883-889
2000
Pasteurella multocida
Heldermon, C.D.; Tlapak-Simmons, V.L.; Baggenstoss, B.A.; Weigel, P.H.
Site-directed mutation of conserved cysteine residues does not inactivate the Streptococcus pyogenes hyaluronan synthase
Glycobiology
11
1017-1024
2001
Streptococcus pyogenes
Asplund, T.; Brinck, J.; Suzuki, M.; Briskin, M.J.; Heldin, P.
Characterization of hyaluronan synthase from a human glioma cell line
Biochim. Biophys. Acta
1380
377-388
1998
Homo sapiens
Klewes, L.; Prehm, P.
Intracellular signal transduction for serum activation of the hyaluronan synthase in eukaryotic cell lines
J. Cell. Physiol.
160
539-544
1994
Mus musculus
Sayo, T.; Sugiyama, Y.; Takahashi, Y.; Ozawa, N.; Sakai, S.; Ishikawa, O.; Tamura, M.; Inoue, S.
Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes
J. Invest. Dermatol.
118
43-48
2002
Homo sapiens
Uchiyama, T.; Sakuta, T.; Kanayama, T.
Regulation of hyaluronan synthases in mouse uterine cervix
Biochem. Biophys. Res. Commun.
327
927-932
2005
Mus musculus
Tlapak-Simmons, V.L.; Baron, C.A.; Weigel, P.H.
Characterization of the purified hyaluronan synthase from Streptococcus equisimilis
Biochemistry
43
9234-9242
2004
Streptococcus dysgalactiae subsp. equisimilis
Jing, W.; DeAngelis, P.L.
Analysis of the two active sites of the hyaluronan synthase and the chondroitin synthase of Pasteurella multocida
Glycobiology
13
661-671
2003
Pasteurella multocida, Pasteurella multocida type A
Kumari, K.; Weigel, P.H.
Identification of a membrane-localized cysteine cluster near the substrate-binding sites of the Streptococcus equisimilis hyaluronan synthase
Glycobiology
15
529-539
2005
Streptococcus dysgalactiae subsp. equisimilis
Itano, N.; Kimata, K.
Mammalian hyaluronan synthases
IUBMB Life
54
195-199
2002
Homo sapiens, Mus musculus
Weigel, P.H.
Functional characteristics and catalytic mechanisms of the bacterial hyaluronan synthases
IUBMB Life
54
201-211
2002
Pasteurella multocida, Streptococcus pyogenes
Kumari, K.; Tlapak-Simmons, V.L.; Baggenstoss, B.A.; Weigel, P.H.
The streptococcal hyaluronan synthases are inhibited by sulfhydryl-modifying reagents, but conserved cysteine residues are not essential for enzyme function
J. Biol. Chem.
277
13943-13951
2002
Streptococcus dysgalactiae subsp. equisimilis, Streptococcus pyogenes (Q5X9A9), Streptococcus pyogenes
Pummill, P.E.; DeAngelis, P.L.
Evaluation of critical structural elements of UDP-sugar substrates and certain cysteine residues of a vertebrate hyaluronan synthase
J. Biol. Chem.
277
21610-21616
2002
Xenopus laevis
Itano, N.; Sawai, T.; Atsumi, F.; Miyaishi, O.; Taniguchi, S.; Kannagi, R.; Hamaguchi, M.; Kimata, K.
Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation
J. Biol. Chem.
279
18679-18687
2004
Rattus norvegicus (O35776), Rattus norvegicus (Q8CH92), Rattus norvegicus (Q8CH93)
Hoshi, H.; Nakagawa, H.; Nishiguchi, S.; Iwata, K.; Niikura, K.; Monde, K.; Nishimura, S.
An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli
J. Biol. Chem.
279
2341-2349
2004
Homo sapiens
Tlapak-Simmons, V.L.; Baron, C.A.; Gotschall, R.; Haque, D.; Canfield, W.M.; Weigel, P.H.
Hyaluronan biosynthesis by class I streptococcal hyaluronan synthases occurs at the reducing end
J. Biol. Chem.
280
13012-13018
2005
Streptococcus dysgalactiae subsp. equisimilis, Streptococcus pyogenes
Rilla, K.; Siiskonen, H.; Spicer, A.P.; Hyttinen, J.M.; Tammi, M.I.; Tammi, R.H.
Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity
J. Biol. Chem.
280
31890-31897
2005
Mus musculus
Krupa, J.C.; Shaya, D.; Chi, L.; Linhardt, R.J.; Cygler, M.; Withers, S.G.; Mort, J.S.
Quantitative continuous assay for hyaluronan synthase
Anal. Biochem.
361
218-225
2007
Pasteurella multocida
Goentzel, B.J.; Weigel, P.H.; Steinberg, R.A.
Recombinant human hyaluronan synthase 3 is phosphorylated in mammalian cells
Biochem. J.
396
347-354
2006
Homo sapiens (O00219), Homo sapiens
Pummill, P.E.; Kane, T.A.; Kempner, E.S.; DeAngelis, P.L.
The functional molecular mass of the Pasteurella hyaluronan synthase is a monomer
Biochim. Biophys. Acta
1770
286-290
2007
Pasteurella multocida
Adamia, S.; Reiman, T.; Crainie, M.; Mant, M.J.; Belch, A.R.; Pilarski, L.M.
Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma
Blood
105
4836-4844
2005
Homo sapiens (Q92839), Homo sapiens
Tien, J.Y.; Spicer, A.P.
Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns
Dev. Dyn.
233
130-141
2005
Mus musculus (O08650), Mus musculus (P70312), Mus musculus (Q61647), Mus musculus
Jong, A.; Wu, C.H.; Chen, H.M.; Luo, F.; Kwon-Chung, K.J.; Chang, Y.C.; Lamunyon, C.W.; Plaas, A.; Huang, S.H.
Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of C. neoformans infection
Eukaryot. Cell
6
1486-1496
2007
Cryptococcus neoformans
Nishida, Y.; Knudson, W.; Knudson, C.B.; Ishiguro, N.
Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity
Exp. Cell Res.
307
194-203
2005
Homo sapiens (Q92819), Homo sapiens
Nikitovic, D.; Zafiropoulos, A.; Katonis, P.; Tsatsakis, A.; Theocharis, A.D.; Karamanos, N.K.; Tzanakakis, G.N.
Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells
IUBMB Life
58
47-53
2006
Homo sapiens (Q92819), Homo sapiens
Kumari, K.; Baggenstoss, B.A.; Parker, A.L.; Weigel, P.H.
Mutation of two intramembrane polar residues conserved within the hyaluronan synthase family alters hyaluronan product size
J. Biol. Chem.
281
11755-11760
2006
Streptococcus dysgalactiae subsp. equisimilis
Weigel, P.H.; Kyossev, Z.; Torres, L.C.
Phospholipid dependence and liposome reconstitution of purified hyaluronan synthase
J. Biol. Chem.
281
36542-36551
2006
Streptococcus dysgalactiae subsp. equisimilis
Tracy, B.S.; Avci, F.Y.; Linhardt, R.J.; DeAngelis, P.L.
Acceptor specificity of the Pasteurella hyaluronan and chondroitin synthases and production of chimeric glycosaminoglycans
J. Biol. Chem.
282
337-344
2007
Pasteurella multocida
Wilkinson, T.S.; Bressler, S.L.; Evanko, S.P.; Braun, K.R.; Wight, T.N.
Overexpression of hyaluronan synthases alters vascular smooth muscle cell phenotype and promotes monocyte adhesion
J. Cell. Physiol.
206
378-385
2006
Mus musculus
Adams, J.R.; Sander, G.; Byers, S.
Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line
Matrix Biol.
25
40-46
2006
Homo sapiens (O00219), Homo sapiens (Q92819)
Kyossev, Z.; Weigel, P.H.
An enzyme capture assay for analysis of active hyaluronan synthases
Anal. Biochem.
371
62-70
2007
Homo sapiens, Streptococcus dysgalactiae subsp. equisimilis
Kakizaki, I.; Itano, N.; Kimata, K.; Hanada, K.; Kon, A.; Yamaguchi, M.; Takahashi, T.; Takagaki, K.
Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation
Arch. Biochem. Biophys.
471
85-93
2008
Homo sapiens
Li, L.; Asteriou, T.; Bernert, B.; Heldin, C.H.; Heldin, P.
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB
Biochem. J.
404
327-336
2007
Homo sapiens, Mus musculus
Campo, G.M.; Avenoso, A.; Campo, S.; DAscola, A.; Ferlazzo, A.M.; Calatroni, A.
Differential effect of growth factors on hyaluronan synthase gene expression in fibroblasts exposed to oxidative stress
Biochemistry
72
974-982
2007
Homo sapiens
Stuhlmeier, K.M.
Prostaglandin E2: A potent activator of hyaluronan synthase 1 in type-B-synoviocytes
Biochim. Biophys. Acta
1770
121-129
2007
Homo sapiens
Allison, D.D.; Vasco, N.; Braun, K.R.; Wight, T.N.; Grande-Allen, K.J.
The effect of endogenous overexpression of hyaluronan synthases on material, morphological, and biochemical properties of uncrosslinked collagen biomaterials
Biomaterials
28
5509-5517
2007
Rattus norvegicus
Allison, D.D.; Wight, T.N.; Ripp, N.J.; Braun, K.R.; Grande-Allen, K.J.
Endogenous overexpression of hyaluronan synthases within dynamically cultured collagen gels: Implications for vascular and valvular disease
Biomaterials
29
2969-2976
2008
Rattus norvegicus
Mao, Z.; Chen, R.R.
Recombinant synthesis of hyaluronan by Agrobacterium sp
Biotechnol. Prog.
23
1038-1042
2007
Pasteurella multocida (Q7BLV3), Pasteurella multocida
Bartolo, R.C.; Donald, J.A.
The distribution of renal hyaluronan and the expression of hyaluronan synthases during water deprivation in the Spinifex hopping mouse, Notomys alexis
Comp. Biochem. Physiol. A
148
853-860
2007
Notomys alexis (Q27J86), Notomys alexis (Q27J87), Notomys alexis (Q27J88)
Nishitsuka, K.; Kashiwagi, Y.; Tojo, N.; Kanno, C.; Takahashi, Y.; Yamamoto, T.; Heldin, P.; Yamashita, H.
Hyaluronan production regulation from porcine hyalocyte cell line by cytokines
Exp. Eye Res.
85
539-545
2007
Sus scrofa
Bourguignon, L.Y.; Gilad, E.; Peyrollier, K.
Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration
J. Biol. Chem.
282
19426-19441
2007
Homo sapiens (Q92819), Homo sapiens (Q92839), Homo sapiens (Q96RV2), Homo sapiens
Bharadwaj, A.G.; Rector, K.; Simpson, M.A.
Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis
J. Biol. Chem.
282
20561-20572
2007
Homo sapiens
Meran, S.; Thomas, D.; Stephens, P.; Martin, J.; Bowen, T.; Phillips, A.; Steadman, R.
Involvement of hyaluronan in regulation of fibroblast phenotype
J. Biol. Chem.
282
25687-25697
2007
Homo sapiens
Stuhlmeier, K.M.
Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs
J. Biol. Chem.
283
16781-16789
2008
Homo sapiens
Carulli, D.; Rhodes, K.E.; Fawcett, J.W.
Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum
J. Comp. Neurol.
501
83-94
2007
Rattus norvegicus
Sim, G.S.; Lee, D.H.; Kim, J.H.; An, S.K.; Choe, T.B.; Kwon, T.J.; Pyo, H.B.; Lee, B.C.
Black rice (Oryza sativa L. var. japonica) hydrolyzed peptides induce expression of hyaluronan synthase 2 gene in HaCaT keratinocytes
J. Microbiol. Biotechnol.
17
271-279
2007
Homo sapiens (Q92819), Homo sapiens
Fischer, J.W.; Schroer, K.
Regulation of hyaluronan synthesis by vasodilatory prostaglandins. Implications for atherosclerosis
Thromb. Haemost.
98
287-295
2007
Mammalia
Sheng, J.Z.; Ling, P.X.; Zhu, X.Q.; Guo, X.P.; Zhang, T.M.; He, Y.L.; Wang, F.S.
Use of induction promoters to regulate hyaluronan synthase and UDP-glucose-6-dehydrogenase of Streptococcus zooepidemicus expression in Lactococcus lactis: a case study of the regulation mechanism of hyaluronic acid polymer
J. Appl. Microbiol.
107
136-144
2009
Streptococcus equi subsp. zooepidemicus
David-Raoudi, M.; Deschrevel, B.; Leclercq, S.; Galera, P.; Boumediene, K.; Pujol, J.P.
Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt
Arthritis Rheum.
60
760-770
2009
Homo sapiens (O00219), Homo sapiens (Q92819), Homo sapiens (Q92839), Homo sapiens
Berdiaki, A.; Nikitovic, D.; Tsatsakis, A.; Katonis, P.; Karamanos, N.K.; Tzanakakis, G.N.
bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells
Biochim. Biophys. Acta
1790
1258-1265
2009
Homo sapiens (Q92839)
Miyake, Y.; Sakurai, M.; Tanaka, S.; Tunjung, W.A.; Yokoo, M.; Matsumoto, H.; Aso, H.; Yamaguchi, T.; Sato, E.
Expression of hyaluronan synthase 1 and distribution of hyaluronan during follicular atresia in pig ovaries
Biol. Reprod.
80
249-257
2009
Sus scrofa
Adamia, S.; Reichert, A.A.; Kuppusamy, H.; Kriangkum, J.; Ghosh, A.; Hodges, J.J.; Pilarski, P.M.; Treon, S.P.; Mant, M.J.; Reiman, T.; Belch, A.R.; Pilarski, L.M.
Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia
Blood
112
5111-5121
2008
Homo sapiens (Q92839), Homo sapiens
Nykopp, T.; Rilla, K.; Sironen, R.; Tammi, M.; Tammi, R.; Hmlinen, K.; Heikkinen, A.; Komulainen, M.; Kosma, V.; Anttila, M.
Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: Inverse correlation between HYAL1 and hyaluronan content
BMC Cancer
9
143
2009
Homo sapiens (O00219), Homo sapiens (Q92819)
Campo, G.M.; Avenoso, A.; Campo, S.; DAscola, A.; Traina, P.; Calatroni, A.
Effect of cytokines on hyaluronan synthase activity and response to oxidative stress by fibroblasts
Br. J. Biomed. Sci.
66
28-36
2009
Homo sapiens (O00219), Homo sapiens (Q92819), Homo sapiens (Q92839)
Kultti, A.; Pasonen-Seppaenen, S.; Jauhiainen, M.; Rilla, K.J.; Kaernae, R.; Pyoeriae, E.; Tammi, R.H.; Tammi, M.I.
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
Exp. Cell Res.
315
1914-1923
2009
Homo sapiens (O00219), Homo sapiens (Q92819)
Makkonen, K.M.; Pasonen-Seppaenen, S.; Toerroenen, K.; Tammi, M.I.; Carlberg, C.
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling
J. Biol. Chem.
284
18270-18281
2009
Homo sapiens (Q92819), Homo sapiens
Ghosh, A.; Kuppusamy, H.; Pilarski, L.M.
Aberrant splice variants of HAS1 (hyaluronan synthase 1) multimerize with and modulate normally spliced HAS1 protein: a potential mechanism promoting human cancer
J. Biol. Chem.
284
18840-18850
2009
Homo sapiens (Q92839), Homo sapiens
Vigetti, D.; Genasetti, A.; Karousou, E.; Viola, M.; Clerici, M.; Bartolini, B.; Moretto, P.; De Luca, G.; Hascall, V.C.; Passi, A.
Modulation of hyaluronan synthase activity in cellular membrane fractions
J. Biol. Chem.
284
30684-30694
2009
Homo sapiens
Ruegheimer, L.; Olerud, J.; Johnsson, C.; Takahashi, T.; Shimizu, K.; Hansell, P.
Hyaluronan synthases and hyaluronidases in the kidney during changes in hydration status
Matrix Biol.
28
390-395
2009
Rattus norvegicus, Rattus norvegicus (O35776)
Dunn, K.M.; Lee, P.K.; Wilson, C.M.; Iida, J.; Wasiluk, K.R.; Hugger, M.; McCarthy, J.B.
Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity
Surgery
145
322-329
2009
Homo sapiens (O00219), Homo sapiens (Q92819)
Medina, A.P.; Lin, J.; Weigel, P.H.
Hyaluronan synthase mediates dye translocation across liposomal membranes
BMC Biochem.
13
2-2
2012
Streptococcus dysgalactiae subsp. equisimilis
Nykopp, T.K.; Rilla, K.; Tammi, M.I.; Tammi, R.H.; Sironen, R.; Haemaelaeinen, K.; Kosma, V.M.; Heinonen, S.; Anttila, M.
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
BMC Cancer
10
512
2010
Homo sapiens
Caskey, R.C.; Allukian, M.; Lind, R.C.; Herdrich, B.J.; Xu, J.; Radu, A.; Mitchell, M.E.; Liechty, K.W.
Lentiviral-mediated over-expression of hyaluronan synthase-1 (HAS-1) decreases the cellular inflammatory response and results in regenerative wound repair
Cell Tissue Res.
351
117-125
2013
Mus musculus, Mus musculus C57BL/6
Weigel, P.H.; Baggenstoss, B.A.
Hyaluronan synthase polymerizing activity and control of product size are discrete enzyme functions that can be uncoupled by mutagenesis of conserved cysteines
Glycobiology
22
1302-1310
2012
Streptococcus dysgalactiae subsp. equisimilis
Karousou, E.; Kamiryo, M.; Skandalis, S.S.; Ruusala, A.; Asteriou, T.; Passi, A.; Yamashita, H.; Hellman, U.; Heldin, C.H.; Heldin, P.
The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination
J. Biol. Chem.
285
23647-23654
2010
Mus musculus
Vigetti, D.; Clerici, M.; Deleonibus, S.; Karousou, E.; Viola, M.; Moretto, P.; Heldin, P.; Hascall, V.C.; De Luca, G.; Passi, A.
Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells
J. Biol. Chem.
286
7917-7924
2011
Homo sapiens (Q92819)
Vigetti, D.; Deleonibus, S.; Moretto, P.; Karousou, E.; Viola, M.; Bartolini, B.; Hascall, V.C.; Tammi, M.; De Luca, G.; Passi, A.
Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis
J. Biol. Chem.
287
35544-35555
2012
Homo sapiens
Rilla, K.; Oikari, S.; Jokela, T.A.; Hyttinen, J.M.; Kaernae, R.; Tammi, R.H.; Tammi, M.I.
Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3
J. Biol. Chem.
288
5973-5983
2013
Homo sapiens (O00219), Homo sapiens (Q92819), Homo sapiens (Q92839), Homo sapiens
Hubbard, C.; McNamara, J.T.; Azumaya, C.; Patel, M.S.; Zimmer, J.
The hyaluronan synthase catalyzes the synthesis and membrane translocation of hyaluronan
J. Mol. Biol.
418
21-31
2012
Streptococcus dysgalactiae subsp. equisimilis
Pure, E.; Krolikoski, M.; Monslow, J.
Role for hyaluronan synthase 3 in the response to vascular injury
Arterioscler. Thromb. Vasc. Biol.
36
224-225
2016
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Siiskonen, H.; Kaernae, R.; Hyttinen, J.M.; Tammi, R.H.; Tammi, M.I.; Rilla, K.
Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat
Exp. Cell Res.
320
153-163
2014
Homo sapiens
Takabe, P.; Bart, G.; Ropponen, A.; Rilla, K.; Tammi, M.; Tammi, R.; Pasonen-Seppaenen, S.
Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion
Exp. Cell Res.
337
1-15
2015
Homo sapiens
Siiskonen, H.; Oikari, S.; Pasonen-Seppaenen, S.; Rilla, K.
Hyaluronan synthase 1: a mysterious enzyme with unexpected functions
Front. Immunol.
6
43
2015
Homo sapiens (Q92839)
Toerroenen, K.; Nikunen, K.; Kaernae, R.; Tammi, M.; Tammi, R.; Rilla, K.
Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes
Histochem. Cell Biol.
141
17-31
2014
Mus musculus (O08650), Mus musculus (P70312), Mus musculus (Q61647), Mus musculus
Kooy, F.; Beeftink, H.; Eppink, M.; Tramper, J.; Eggink, G.; Boeriu, C.
Kinetic and structural analysis of two transferase domains in Pasteurella multocida hyaluronan synthase
J. Mol. Catal. B
102
138-145
2014
Pasteurella multocida (Q7BLV3)
-
Vigetti, D.; Viola, M.; Karousou, E.; De Luca, G.; Passi, A.
Metabolic control of hyaluronan synthases
Matrix Biol.
35
8-13
2014
Mammalia, Streptococcus sp., Pasteurella multocida (Q7BLV3)
Li, Y.; Liang, J.; Yang, T.; Monterrosa Mena, J.; Huan, C.; Xie, T.; Kurkciyan, A.; Liu, N.; Jiang, D.; Noble, P.W.
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis
Matrix Biol.
55
35-48
2016
Mus musculus (P70312), Mus musculus
Garoby-Salom, S.; Rouahi, M.; Mucher, E.; Auge, N.; Salvayre, R.; Negre-Salvayre, A.
Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL
Redox Biol.
4
118-126
2015
Mus musculus (P70312), Mus musculus 129/Sv (P70312)
Chavoshinejad, R.; Marei, W.F.; Hartshorne, G.M.; Fouladi-Nashta, A.A.
Localisation and endocrine control of hyaluronan synthase (HAS) 2, HAS3 and CD44 expression in sheep granulosa cells
Reprod. Fertil. Dev.
28
765-775
2016
Ovis aries, Ovis aries (W5PN25), Ovis aries (W5PZY5)
Eisele, A.; Zaun, H.; Kuballa, J.; Elling, L.
In vitro one-pot enzymatic synthesis of hyaluronic acid from sucrose and N-acetylglucosamine optimization of the enzyme module system and nucleotide sugar regeneration
ChemCatChem
10
2969-2981
2018
Pasteurella multocida (Q7BLV3)
-
Yang, J.; Cheng, F.; Yu, H.; Wang, J.; Guo, Z.; Stephanopoulos, G.
Key role of the carboxyl terminus of hyaluronan synthase in processive synthesis and size control of hyaluronic acid polymers
Biomacromolecules
18
1064-1073
2017
Streptococcus dysgalactiae subsp. equisimilis (A0A514TRT9), Streptococcus dysgalactiae subsp. equisimilis
Zhang, L.; Huang, H.; Wang, H.; Chen, J.; Du, G.; Kang, Z.
Rapid evolution of hyaluronan synthase to improve hyaluronan production and molecular mass in Bacillus subtilis
Biotechnol. Lett.
38
2103-2108
2016
Streptococcus equi subsp. zooepidemicus (Q84GC8), Streptococcus equi subsp. zooepidemicus
Passi, A.; Vigetti, D.; Buraschi, S.; Iozzo, R.V.
Dissecting the role of hyaluronan synthases in the tumor microenvironment
FEBS J.
286
2937-2949
2019
Mus musculus (P70312), Homo sapiens (Q92819)
Weigel, P.H.; Baggenstoss, B.A.; Washburn, J.L.
Hyaluronan synthase assembles hyaluronan on a [GlcNAc(beta1,4)]n-GlcNAc(alpha1->)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end
Glycobiology
27
536-554
2017
Streptococcus dysgalactiae subsp. equisimilis (A0A514TRT9), Streptococcus dysgalactiae subsp. equisimilis
Yoshida, H.; Aoki, M.; Komiya, A.; Endo, Y.; Kawabata, K.; Nakamura, T.; Sakai, S.; Sayo, T.; Okada, Y.; Takahashi, Y.
HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts
J. Biol. Chem.
295
2483-2494
2020
Homo sapiens (Q92819), Homo sapiens
Yang, G.; Jiang, B.; Cai, W.; Liu, S.; Zhao, S.
Hyaluronan and hyaluronan synthases expression and localization in embryonic mouse molars
J. Mol. Histol.
47
413-420
2016
Mus musculus (O08650), Mus musculus (P70312), Mus musculus (Q61647)
Lai, Z.; Teo, C.
Cloning and expression of hyaluronan synthase (hasA) in recombinant Escherichia coli BL21 and its hyaluronic acid production in shake flask culture
Malays. J. Microbiol.
15
575-582
2019
Streptococcus equi subsp. zooepidemicus (Q84GC8)
-
Homann, S.; Grandoch, M.; Kiene, L.S.; Podsvyadek, Y.; Feldmann, K.; Rabausch, B.; Nagy, N.; Lehr, S.; Kretschmer, I.; Oberhuber, A.; Bollyky, P.; Fischer, J.W.
Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression
Matrix Biol.
66
67-80
2018
Mus musculus (O08650)
Mehic, M.; de Sa, V.K.; Hebestreit, S.; Heldin, C.H.; Heldin, P.
The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function
Oncogenesis
6
e348
2017
Homo sapiens (Q92819), Homo sapiens
Agarwal, G.; K V, K.; Prasad, S.B.; Bhaduri, A.; Jayaraman, G.
Biosynthesis of Hyaluronic acid polymer Dissecting the role of sub structural elements of hyaluronan synthase
Sci. Rep.
9
12510
2019
Streptococcus equi subsp. zooepidemicus (Q84GC8)
Yang, Y.M.; Noureddin, M.; Liu, C.; Ohashi, K.; Kim, S.Y.; Ramnath, D.; Powell, E.E.; Sweet, M.J.; Roh, Y.S.; Hsin, I.F.; Deng, N.; Liu, Z.; Liang, J.; Mena, E.; Shouhed, D.; Schwabe, R.F.; Jiang, D.; Lu, S.C.; Noble, P.W.; Seki, E.
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis
Sci. Transl. Med.
11
eaat9284
2019
Mus musculus (P70312), Mus musculus, Homo sapiens (Q92819), Homo sapiens
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