Information on EC 2.4.1.196 - nicotinate glucosyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.4.1.196
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RECOMMENDED NAME
GeneOntology No.
nicotinate glucosyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-glucose + nicotinate = UDP + N-glucosylnicotinate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
N-glucosylnicotinate metabolism
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:nicotinate N-glucosyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
120858-56-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
XD-6, inducible enzyme by culture with niacin
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Manually annotated by BRENDA team
Hoffm., parsley
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Manually annotated by BRENDA team
HH258 and F81
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-glucose + catechol
?
show the reaction diagram
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?
UDP-glucose + nicotinate
UDP + N-glucosylnicotinate
show the reaction diagram
UDP-glucose + nicotinic acid methyl ester
UDP + N-glucosylnicotinic acid methyl ester
show the reaction diagram
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-
-
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?
UDP-glucose + vanillic acid
?
show the reaction diagram
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-
-
-
?
UDP-glucose + vanillin
?
show the reaction diagram
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-
-
-
?
UDPglucose + nicotinate
?
show the reaction diagram
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the reversible glucosyltransferase reaction provides free nicotinate for the synthesis of NAD+ and NADP+ in pyridine nucleotide cycle
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDPglucose + nicotinate
?
show the reaction diagram
-
the reversible glucosyltransferase reaction provides free nicotinate for the synthesis of NAD+ and NADP+ in pyridine nucleotide cycle
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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no requirement for divalent cations
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-Hydroxynicotinic acid
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73% inhibition at 1 mM
Benzoic acid
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88% inhibition at 1 mM
Cd2+
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at 1 mM
Cu2+
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at 1 mM
Hg2+
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at 1 mM
Isonicotinic acid
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98% inhibition at 1 mM
N1-methylnicotinamide
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33% inhibition at 1 mM
nicotinic acid N-oxide
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31% inhibition at 1 mM
p-chloromercuribenzoate
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Pb2+
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at 1 mM
Salicylamide
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30% inhibition at 1 mM
UTP
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33% inhibition at 1 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.17 - 0.22
nicotinic acid
1.2 - 4.3
UDPglucose
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 11
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at pH 5 nearly inactive, at pH 11 about 50% of activity maximum
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
46000
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gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
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1 * 46000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial