Information on EC 2.4.1.161 - oligosaccharide 4-alpha-D-glucosyltransferase

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The expected taxonomic range for this enzyme is: Entamoeba histolytica

EC NUMBER
COMMENTARY hide
2.4.1.161
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RECOMMENDED NAME
GeneOntology No.
oligosaccharide 4-alpha-D-glucosyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
transfers the non-reducing terminal alpha-D-glucose residue from a (1->4)-alpha-D-glucan to the 4-position of a free glucose or of a glucosyl residue at the non-reducing terminus of a (1->4)-alpha-D-glucan, thus bringing about the rearrangement of oligosaccharides
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
(1->4)-alpha-D-glucan:(1->4)-alpha-D-glucan 4-alpha-D-glucosyltransferase
The enzyme acts on amylose, amylopectin, glycogen and maltooligosaccharides. No detectable free glucose is formed, indicating the enzyme does not act as a hydrolase. The enzyme from the bacterium Cellvibrio japonicus has the highest activity with maltotriose as a donor, and also accepts maltose [3], while the enzyme from amoeba does not accept maltose [1,2]. Oligosaccharides with 1->6 linkages cannot function as donors, but can act as acceptors [3]. Unlike EC 2.4.1.25, 4-alpha-glucanotransferase, this enzyme can transfer only a single glucosyl residue.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-92-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-D-glucan + alpha-D-glucan
?
show the reaction diagram
additional information
?
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enzyme may be biologically relevant in the environment of the intestinal tract of man
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha-D-glucan + alpha-D-glucan
?
show the reaction diagram
additional information
?
-
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enzyme may be biologically relevant in the environment of the intestinal tract of man
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-deoxynojirimycin
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Bay h 5595
acarbose
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BAY g 5421
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
PDB
SCOP
CATH
ORGANISM
UNIPROT
Cellvibrio japonicus (strain Ueda107)
Cellvibrio japonicus (strain Ueda107)
Cellvibrio japonicus (strain Ueda107)
Cellvibrio japonicus (strain Ueda107)
Cellvibrio japonicus (strain Ueda107)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
47000
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gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE