Reference on EC 2.4.1.16 - chitin synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sburlati, A.; Cabib, E.
Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae
J. Biol. Chem.
261
15147-15152
1986
Saccharomyces cerevisiae
Cohen, E.; Elster, I.; Chet, I.
Properties and inhibition of Sclerotium rolfsii chitin synthetase
Pestic. Sci.
17
175-182
1986
Athelia rolfsii
-
Huizar, H.E.; Aronson, J.M.
Chitin synthase of Apodachlya
Exp. Mycol.
9
302-309
1985
Apodachlya sp.
-
Selitrennikoff, C.P.
Chitin synthetase activity of Neurospora crassa
Exp. Mycol.
9
179-182
1985
Neurospora crassa
-
Selitrennikoff, C.P.
Calcofluor white inhibits Neurospora chitin synthetase activity
Exp. Mycol.
8
269-272
1984
Neurospora crassa
-
Haenseler, E.; Nyhlen, L.E.; Rast, D.M.
Isolation and properties of chitin synthetase from Agaricus bisporus
Exp. Mycol.
7
17-30
1983
Agaricus bisporus
-
Cohen, E.; Casida, J.E.
Properties and inhibition of insect integumental chitin synthetase
Pestic. Biochem. Physiol.
17
301-306
1982
Hyalophora cecropia, Trichoplusia ni
-
Mayer, R.T.; Chen, A.C.; DeLoach, J.R.
Characterization of a chitin synthase from the stable fly, Stomoxys calcitrans
Insect Biochem.
10
549-556
1980
Stomoxys calcitrans
-
Cohen, E.; Casida, J.E.
Properties of Tribolium gut chitin synthetase
Pestic. Biochem. Physiol.
13
121-128
1980
Galleria mellonella, Tenebrio molitor, Tribolium brevicornis, Tribolium castaneum, Tribolium confusum
-
Cabib, E.; Kang, M.S.; Au-Young, J.
Chitin synthase from Saccharomyces cerevisiae
Methods Enzymol.
138
643-649
1987
Saccharomyces cerevisiae
Pfefferle, W.; Anke, H.; Bross, M.; Steglich, W.
Inhibition of solubilized chitin synthase by chlorinated aromatic compounds isolated from Mushroom cultures
Agric. Biol. Chem.
54
1381-1384
1990
Coprinopsis cinerea
-
Gay, L.; Hebraud, M.; Girard, V.; Fevre, M.
Chitin synthase activity from Neocallimastix frontalis, an anaerobic rumen fungus
J. Gen. Microbiol.
135
279-283
1989
Neocallimastix frontalis
-
Machida, S.; Saito, M.
Purification and characterization of membrane-bound chitin synthase
J. Biol. Chem.
268
1702-1707
1993
Absidia glauca
Cabib, E.
Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins
Antimicrob. Agents Chemother.
35
170-173
1991
Saccharomyces cerevisiae
Faehnrich, M.; Ahlers, J.
Improved assay and mechanism of the reaction catalyzed by the chitin synthase from Saccharomyces cerevisiae
Eur. J. Biochem.
121
113-118
1981
Saccharomyces cerevisiae
Gow, L.A.; Selitrennikoff, C.P.
Chitin synthetase of Neurospora crassa: inhibition by nikkomycin, polyoxin B, and UDP
Curr. Microbiol.
11
211-216
1984
Neurospora crassa
-
Hardy, J.C.; Gooday, G.W.
Stability and zymogenic nature of chitin synthase from Candida albicans
Curr. Microbiol.
9
51-54
1983
Candida albicans
-
Causier, B.E.; Milling, R.J.; Foster, S.G.; Adams, D.J.
Characterization of chitin synthase from Botrytis cinerea
Microbiology
140
2199-2205
1994
Botrytis cinerea
-
Ulane, R.E.; Cabib, E.
The activating system of chitin synthetase from Saccharomyces cerevisiae. Purification and properties of the activating factor
J. Biol. Chem.
251
3367-3374
1976
Saccharomyces cerevisiae
Selitrennikoff, C.P.
Chitin synthase activity from the slime variant of Neurospora crassa
Biochim. Biophys. Acta
571
224-232
1979
Neurospora crassa
Lopez-Romero, E.; Ruiz-Herrera, J.; Bartnicki-Garcia, S.
Purification and properties of an inhibitory protein of chitin synthetase from Mucor rouxii
Biochim. Biophys. Acta
525
338-345
1978
Amylomyces rouxii
Ryder, N.S.; Peberdy, J.F.
Chitin synthase in Aspergillus nidulans: properties and proteolytic activation
J. Gen. Microbiol.
99
69-76
1977
Aspergillus nidulans
-
Rast, D.M.; Bartnicki-Garcia, S.
Effects of amphotericin B, nystatin, and other polyene antibiotics on chitin synthase
Proc. Natl. Acad. Sci. USA
78
1233-1236
1981
Amylomyces rouxii, Amylomyces rouxii IM-80 / CCUG 22422 / CBS 416.77 / CCM F-220 / DSM 1191 / ATCC 24905
Peberdy, J.F.; Moore, P.M.
Chitin synthase in Mortierella vinacea: properties, cellular location and synthesis in growing cultures
J. Gen. Microbiol.
90
228-236
1975
Umbelopsis vinacea
Gooday, G.W.; de Rousset-Hall, A.
Properties of chitin synthetase from Coprinus cinereus
J. Gen. Microbiol.
89
137-145
1975
Coprinopsis cinerea
-
De Rousett-Hall, A.; Gooday, G.W.
A kinetic study of a solubilized chitin synthetase preparation from Coprinus cinereus
J. Gen. Microbiol.
89
146-154
1975
Coprinopsis cinerea
-
Montgomery, G.W.G.; Adams, D.J.; Gooday, G.W.
Studies on the purification of chitin synthase from Coprinus cinereus
J. Gen. Microbiol.
130
291-297
1984
Coprinopsis cinerea
-
Moore, P.M.; Peberdy, J.F.
A particulate chitin synthase from Aspergillus flavus Link: the properties, location, and levels of activity in mycelium and regenerating protoplast preparations
Can. J. Microbiol.
22
915-921
1976
Aspergillus flavus
Duran, A.; Cabib, E.
Solubilization and partial purification of yeast chitin synthetase. Confirmation of the zymogenic nature of the enzyme
J. Biol. Chem.
253
4419-4425
1978
Aspergillus flavus, Saccharomyces cerevisiae
Horst, M.N.
The biosynthesis of crustacean chitin by a microsomal enzyme from larval brine shrimp
J. Biol. Chem.
256
1412-1419
1981
Artemia salina
Manocha, M.S.; Begum, A.
Properties of chitin synthase from mucoraceous hosts of a mycoparasite
Can. J. Microbiol.
31
6-12
1985
Choanephora cucurbitarum, Phascolomyces articulosus
-
Adjimani, J.P.; Manocha, M.S.
A comparative study of properties of chitin synthase from two Mortierella species
Can. J. Microbiol.
31
1035-1040
1985
Mortierella candelabrum, Mortierella pusilla
-
Orlean, P.
Two chitin synthases in Saccharomyces cerevisiae
J. Biol. Chem.
262
5732-5739
1987
Saccharomyces cerevisiae
Kang, M.S.; Elango, N.; Mattia, E.; Au-Young, J.; Robbins, P.W.; Cabib, E.
Isolation of chitin synthetase from Saccharomyces cerevisiae. Purification of an enzyme by entrapment in the reaction product
J. Biol. Chem.
259
14966-14972
1984
Saccharomyces cerevisiae
Nung Jan, Y.
Properties and cellular localization of chitin synthetase in Phycomyces blakesleeanus
J. Biol. Chem.
249
1973-1979
1974
Phycomyces blakesleeanus
Ruiz-Herrera, J.; Lopez-Romero, E.; Bartnicki-Garcia, S.
Properties of chitin synthetase in isolated chitosomes from yeast cells of Mucor rouxii
J. Biol. Chem.
252
3338-3343
1977
Amylomyces rouxii
Leal-Morales, C.A.; Bracker, C.E.; Bartnicki-Garcia, S.
Distribution of chitin synthetase and various membrane marker enzymes in chitosomes and other organelles of the slime mutant of Neurospora crassa
Exp. Mycol.
18
168-179
1994
Neurospora crassa
-
Valdivieso, M.H.; Duran, A.; Roncero, C.
Chitin synthases in yeast and fungi
EXS
87
55-69
1999
Aspergillus nidulans, Saccharomyces cerevisiae, Candida albicans, Rhizopus microsporus var. oligosporus, Ustilago maydis
Tatsuno, K.; Yamada-Okabe, H.; Takagi, M.; Arisawa, M.; Sudoh, M.
Properties of yeast expressed Aspergillus nidulans chitin synthase B which is essential for hyphal growth
FEMS Microbiol. Lett.
149
279-284
1997
Aspergillus nidulans
Uchida, Y.; Shimmi, O.; Sudoh, M.; Arisawa, M.; Yamada-Okabe, H.
Characterization of chitin synthase 2 of Saccharomyces cerevisiae II: Both full size and processed enzymes are active for chitin synthesis
J. Biochem.
119
659-666
1996
Saccharomyces cerevisiae
Lucero, H.A.; Kuranda, M.J.; Bulik, D.A.
A nonradioactive, high throughput assay for chitin synthase activity
Anal. Biochem.
305
97-105
2002
Saccharomyces cerevisiae
Wang, Z.; Szaniszlo, P.J.
Characterization of WdChs3p, a class III chitin synthase, of Wangiella (Exophiala) dermatitidis, overexpressed in Saccharomyces cerevisiae
Med. Mycol.
40
283-289
2002
Exophiala dermatitidis
Leal-Morales, C.A.; Bracker, C.E.; Bartnicki-Garcia, S.
Subcellular localization, abundance and stability of chitin synthetases 1 and 2 from Saccharomyces cerevisiae
Microbiology
140
2207-2216
1994
Saccharomyces cerevisiae
-
Nagahashi, S.; Sudoh, M.; Ono, N.; Sawada, R.; Yamaguchi, E.; Uchida, Y.; Mio, T.; Takagi, M.; Arisawa, M.; Yamada-Okabe, H.
Characterization of chitin synthase 2 of Saccharomyces cerevisiae. Implication of two highly conserved domains as possible catalytic sites
J. Biol. Chem.
270
13961-13967
1995
Saccharomyces cerevisiae
Muller, C.; McIntyre, M.; Hansen, K.; Nielsen, J.
Metabolic engineering of the morphology of Aspergillus oryzae by altering chitin synthesis
Appl. Environ. Microbiol.
68
1827-1836
2002
Aspergillus oryzae
Kawasaki, T.; Tanaka, M.; Fujie, M.; Usami, S.; Sakai, K.; Yamada, T.
Chitin synthesis in chlorovirus CVK2-infected Chlorella cells
Virology
302
123-131
2002
Chlorovirus CVK2
Harris, M.T.; Lai, K.; Arnold, K.; Martinez, H.F.; Specht, C.A.; Fuhrman, J.A.
Chitin synthase in the filarial parasite, Brugia malayi
Mol. Biochem. Parasitol.
111
351-362
2000
Dirofilaria immitis (Q9GQ90), Brugia malayi (Q9GQC3), Brugia malayi
Leal-Morales, C.A.; Gay, L.; Fevre, M.; Bartnicki-Garcia, S.
The properties and localization of Saprolegnia monoica chitin synthase differ from those of other fungi
Microbiology
143
2473-2483
1997
Saprolegnia monoica
-
Gooday, G.W.
The effect of polyoxin D on morphogenesis in Coprinus cinereus
Biochem. J.
129
17P-18P
1972
Coprinopsis cinerea
Zimoch, L.; Merzendorfer, H.
Immunolocalization of chitin synthase in the tobacco hornworm
Cell Tissue Res.
308
287 -297
2002
Manduca sexta
Bulik, D.A.; Olczak, M.; Lucero, H.A.; Osmond, B.C.; Robbins, P.W.; Specht, C.A.
Chitin synthesis in Saccharomyces cerevisiae in response to supplementation of growth medium with glucosamine and cell wall stress
Eukaryot. Cell
2
886-900
2003
Saccharomyces cerevisiae
Rosa, F.; Sargent, T.D.; Rebbert, M.L.; et al.
Insect chitin synthase cDNA sequence, gene organization and expression
Eur. J. Biochem.
267
6025-6043
2000
Lucilia cuprina, Lucilia sp.
Cabib, E.; Schmidt, M.
Chitin synthase III activity, but not the chitin ring, is required for remedial septa formation in budding yeast
FEMS Microbiol. Lett.
224
299-305
2003
Saccharomyces cerevisiae (P29465), Saccharomyces cerevisiae
Lee, J.I.; Yu, Y.M.; Rho, Y.M.; Park, B.C.; Choi, J.H.; Park, H.M.; Maeng, P.J.
Differential expression of the chsE gene encoding a chitin synthase of Aspergillus nidulans in response to developmental status and growth conditions
FEMS Microbiol. Lett.
249
121-129
2005
Aspergillus nidulans (P78611), Aspergillus nidulans
Lee, J.I.; Lee, M.Y.; Park, B.C.; Choi, J.H.; Park, H.M.; Maeng, P.J.
Differential expression of the chitin synthase genes of Aspergillus nidulans, chsA, chsB and chsC, in response to developmental status and environmental factors
Fungal Genet. Biol.
41
635-646
2004
Aspergillus nidulans (P30584), Aspergillus nidulans (Q00757), Aspergillus nidulans (Q92197), Aspergillus nidulans
Fanelli, E.; Di Vito, M.; Jones, J.T.; De Giorgi, C.
Analysis of chitin synthase function in a plant parasitic nematode, Meloidogyne artiellia, using RNAi
Gene
349
87-95
2005
Meloidogyne artiellia
Ibrahim, G.H; Smartt, C.T.; Kiley, L.M.; Christensen, B.M.
Cloning and characterization of a chitin synthase cDNA from the mosquito Aedes aegypti
Insect Biochem. Mol. Biol.
30
1213-1222
2000
Aedes aegypti
Gagou,M.E.;Kapsetaki, M.; Turberg, A.; Kafetzopoulos,D.
Stage-specific expression of the chitin synthase DmeChSA and DmeChSB genes during the onset of Drosophila metamorphosis
Insect Biochem. Mol. Biol.
32
141 -146
2002
Drosophila melanogaster
Zhu, Y.C.; Specht, C.A.; Dittmer, N.T.; Muthukrishnan, S.; Kanost, M.R.; Kramer, K.J.
Sequence of a cDNA and expression of the gene encoding a putative epidermal chitin synthase of Manduca sexta
Insect Biochem. Mol. Biol.
32
1497 -1506
2002
Manduca sexta
Arakane, Y.; Hogenkamp, D.G.; Zhu, Y.C.; Kramer, K.J.; Specht, C.A.; Beeman, R.W.; Kanost, M.R.; Muthukrishnan, S.
Characterization of two chitin synthase genes of the red flour beetle,T ribolium castaneum and alternate exon usage in one of the genes during development
Insect Biochem. Mol. Biol.
34
291 -304
2004
Tribolium castaneum
Zimoch, L.; Hogenkamp, D.G.; Kramer, K.J.; Muthukrishnan, S.; Merzendorfer, H.
Regulation of chitin synthesis in the larval midgut of Manduca sexta
Insect Biochem. Mol. Biol.
35
515-527
2005
Manduca sexta (Q530Z6), Manduca sexta (Q8T4U2), Manduca sexta
Mio, T.; Sudoh, M.; Satoh, Y.; Nakajima, T.; Arisawa, M.; Yamada-Okabe, H.
Role of three chitin synthase genes in the growth of Candida albicans
J. Bacteriol.
178
2416-2419
1996
Candida albicans
Merzendorfer, H.; Zimoch, L.
Chitin metabolism in insects: structure, function and regulation of chitin synthases and chitinases
J. Exp. Biol.
206
4393-4412
2003
Anopheles gambiae, Anopheles gambiae (Q95UA6), Drosophila melanogaster, Manduca sexta (Q8T4U2), Lucilia cuprina (Q9GU17), Aedes aegypti (Q9NHE6)
Yeager, A.R.; Finney, N.S.
The first direct evaluation of the two-active site mechanism for chitin synthase
J. Org. Chem.
69
613-618
2004
Saccharomyces cerevisiae
Selvaggini, S.; Munro, C.A.; Paschoud, S.; Sanglard, D.; Gow, N.A.
Independent regulation of chitin synthase and chitinase activity in Candida albicans and Saccharomyces cerevisiae
Microbiology
150
921-928
2004
Candida albicans
Sanz, M.; Carrano, L.; Jimenez, C.; Candiani, G.; Trilla, J.A.; Duran, A.; Roncero, C.
Candida albicans strains deficient in CHS7, a key regulator of chitin synthase III, exhibit morphogenetic alterations and attenuated virulence
Microbiology
151
2623-2636
2005
Candida albicans
Munro, C.A.K.W.; Buchan, A.; Henry, K.; Becker, J.M.; Brown, A.J.; Bulawa, C.E.; Gow, N.A.R.
Chs1 of Candida albicans is an essential chitin synthase required for synthesis at the septum and for cell integrity
Mol. Microbiol.
39
1414-1426
2001
Candida albicans
Veronico, P.; et al.
Nematode chitin synthases: gene structure, expression and function in Caenorhabditis elegans and the plant parasitic nematode Meloidogyne artiellia
MOL. GENET. GENOMICS
266
28-34
2001
Meloidogyne artiellia
Gow, N.A.R.; Robbins, P.W.; Lester, J.W.; Brown, A.J.P.; Fonzi, W.A.; Chapman, T.; Kinsman, O.S.
A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans
Proc. Natl. Acad. Sci. USA
91
6126-6220
1994
Candida albicans
-
Campos-Gongora, E.; Ebert, F.; Willhoeft, U.; Said-Fernandez, S.; Tannich, E.
Characterization of chitin synthases from Entamoeba
Protist
155
323-330
2004
Entamoeba dispar, Entamoeba histolytica, Entamoeba invadens
Zheng, L.; Mendoza, L.; Wang, Z.; Liu, H.; Park, C.; Kauffman, S.; Becker, J.M.; Szaniszlo, P.J.
WdChs1p, a class II chitin synthase, is more responsible than WdChs2p (Class I) for normal yeast reproductive growth in the polymorphic, pathogenic fungus Wangiella (Exophiala) dermatitidis
Arch. Microbiol.
185
316-329
2006
Exophiala dermatitidis (P30600), Exophiala dermatitidis
Zhang, Y.; Foster, J.M.; Nelson, L.S.; Ma, D.; Carlow, C.K.
The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively
Dev. Biol.
285
330-339
2005
Caenorhabditis elegans
Ichinomiya, M.; Yamada, E.; Yamashita, S.; Ohta, A.; Horiuchi, H.
Class I and class II chitin synthases are involved in septum formation in the filamentous fungus Aspergillus nidulans
Eukaryot. Cell
4
1125-1136
2005
Aspergillus nidulans (P30583), Aspergillus nidulans (P30584)
Banks, I.R.; Specht, C.A.; Donlin, M.J.; Gerik, K.J.; Levitz, S.M.; Lodge, J.K.
A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans
Eukaryot. Cell
4
1902-1912
2005
Cryptococcus neoformans (Q5KCU4), Cryptococcus neoformans
Grabinska, K.A.; Magnelli, P.; Robbins, P.W.
Prenylation of Saccharomyces cerevisiae Chs4p affects chitin synthase III activity and chitin chain length
Eukaryot. Cell
6
328-336
2007
Saccharomyces cerevisiae
Gautier-Lefebvre, I.; Behr, J.B.; Guillerm, G.; Muzard, M.
Iminosugars as glycosyltransferase inhibitors: synthesis of polyhydroxypyrrolidines and their evaluation on chitin synthase activity
Eur. J. Med. Chem.
40
1255-1261
2005
Saccharomyces cerevisiae, Saccharomyces cerevisiae X2180
Ruiz-Herrera, J.; Xoconostle-Cazares, B.; Reynaga-Pena, C.G.; Leon-Ramirez, C.; Carabez-Trejo, A.
Immunolocalization of chitin synthases in the phytopathogenic dimorphic fungus Ustilago maydis
FEMS Yeast Res.
6
999-1009
2006
Ustilago maydis
Arakane, Y.; Muthukrishnan, S.; Kramer, K.J.; Specht, C.A.; Tomoyasu, Y.; Lorenzen, M.D.; Kanost, M.; Beeman, R.W.
The Tribolium chitin synthase genes TcCHS1 and TcCHS2 are specialized for synthesis of epidermal cuticle and midgut peritrophic matrix
Insect Mol. Biol.
14
453-463
2005
Tribolium castaneum (Q6WD22), Tribolium castaneum
Merzendorfer, H.
Insect chitin synthases: a review
J. Comp. Physiol. B
176
1-15
2006
Anopheles gambiae, Drosophila melanogaster, Manduca sexta, Spodoptera frugiperda, Tribolium castaneum, Lucilia cuprina (Q9GU17)
Foster, J.M.; Zhang, Y.; Kumar, S.; Carlow, C.K.
Parasitic nematodes have two distinct chitin synthases
Mol. Biochem. Parasitol.
142
126-132
2005
Onchocerca volvulus, Onchocerca volvulus (Q4VJB8), Brugia malayi (Q4VW80)
Takeshita, N.; Ohta, A.; Horiuchi, H.
CsmA, a class V chitin synthase with a myosin motor-like domain, is localized through direct interaction with the actin cytoskeleton in Aspergillus nidulans
Mol. Biol. Cell
16
1961-1970
2005
Aspergillus nidulans
Takeshita, N.; Yamashita, S.; Ohta, A.; Horiuchi, H.
Aspergillus nidulans class V and VI chitin synthases CsmA and CsmB, each with a myosin motor-like domain, perform compensatory functions that are essential for hyphal tip growth
Mol. Microbiol.
59
1380-1394
2006
Aspergillus nidulans (O13281), Aspergillus nidulans (Q2L6A0), Aspergillus nidulans
Weber, I.; Assmann, D.; Thines, E.; Steinberg, G.
Polar localizing class V myosin chitin synthases are essential during early plant infection in the plant pathogenic fungus Ustilago maydis
Plant Cell
18
225-242
2006
Ustilago maydis (O13394), Ustilago maydis (O13395), Ustilago maydis (P30598), Ustilago maydis (P30599), Ustilago maydis (Q4P333), Ustilago maydis (Q99126), Ustilago maydis (Q99127), Ustilago maydis
Bahmed, K.; Quiles, F.; Wathier, M.; Bonaly, R.; Benallaoua, S.; Pucci, B.; Coulon, J.
Use of dansyl N-acetyl glucosamine as substrate for chitin synthetase activities
Proc. Biochem.
40
2523-2529
2005
Kluyveromyces bulgaricus
-
Amnuaykanjanasin, A.; Epstein, L.
A class Vb chitin synthase in Colletotrichum graminicola is localized in the growing tips of multiple cell types, in nascent septa, and during septum conversion to an end wall after hyphal breakage
Protoplasma
227
155-164
2006
Colletotrichum graminicola
Martinez-Rucobo, F.W.; Eckhardt-Strelau, L.; Terwisscha van Scheltinga, A.C.
Yeast chitin synthase 2 activity is modulated by proteolysis and phosphorylation
Biochem. J.
417
547-554
2009
Saccharomyces cerevisiae, Saccharomyces cerevisiae Y3437
Kang, T.H.; Hwang, E.I.; Yun, B.S.; Shin, C.S.; Kim, S.U.
Chitin synthase 2 inhibitory activity of O-methyl pisiferic acid and 8,20-dihydroxy-9(11),13-abietadien-12-one, isolated from Chamaecyparis pisifera
Biol. Pharm. Bull.
31
755-759
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae (A6ZKY2), Candida albicans (P23316), Candida albicans
Chen, X.; Tian, H.; Zou, L.; Tang, B.; Hu, J.; Zhang, W.
Disruption of Spodoptera exigua larval development by silencing chitin synthase gene A with RNA interference
Bull. Entomol. Res.
98
613-619
2008
Spodoptera exigua (Q3I5Q4), Spodoptera exigua
Kumar, N.S.; Tang, B.; Chen, X.; Tian, H.; Zhang, W.
Molecular cloning, expression pattern and comparative analysis of chitin synthase gene B in Spodoptera exigua
Comp. Biochem. Physiol. B
149
447-453
2008
Spodoptera exigua (Q06BR7), Spodoptera exigua
Riquelme, M.; Bartnicki-Garcia, S.; Gonzalez-Prieto, J.M.; Sanchez-Leon, E.; Verdin-Ramos, J.A.; Beltran-Aguilar, A.; Freitag, M.
Spitzenkorper localization and intracellular traffic of green fluorescent protein-labeled CHS-3 and CHS-6 chitin synthases in living hyphae of Neurospora crassa
Eukaryot. Cell
6
1853-1864
2007
Neurospora crassa, Neurospora crassa (P30588), Neurospora crassa N623, Neurospora crassa DSM 1257 (P30588)
Martin-Urdiroz, M.; Roncero, M.I.; Gonzalez-Reyes, J.A.; Ruiz-Roldan, C.
ChsVb, a class VII chitin synthase involved in septation, is critical for pathogenicity in Fusarium oxysporum
Eukaryot. Cell
7
112-121
2008
Fusarium oxysporum (Q5YCX0), Fusarium oxysporum
Liu, H.; Szaniszlo, P.J.
Transcription and expression analyses of WdCHS5, which encodes a class V chitin synthase with a myosin motor-like domain in Wangiella (Exophiala) dermatitidis
FEMS Microbiol. Lett.
276
99-105
2007
Exophiala dermatitidis (Q8TGV2), Exophiala dermatitidis
Schmidt, M.; Drgon, T.; Bowers, B.; Cabib, E.
Hyperpolarized growth of Saccharomyces cerevisiae cak1P212S and cla4 mutants weakens cell walls and renders cells dependent on chitin synthase 3
FEMS Yeast Res.
8
362-373
2008
Saccharomyces cerevisiae (P29465), Saccharomyces cerevisiae
Matute, D.R.; Torres, I.P.; Salgado-Salazar, C.; Restrepo, A.; McEwen, J.G.
Background selection at the chitin synthase II (chs2) locus in Paracoccidioides brasiliensis species complex
Fungal Genet. Biol.
44
357-367
2007
Paracoccidioides brasiliensis (Q30LK7), Paracoccidioides brasiliensis (Q30LS3), Paracoccidioides brasiliensis
Chen, X.; Yang, X.; Senthil Kumar, N.; Tang, B.; Sun, X.; Qiu, X.; Hu, J.; Zhang, W.
The class A chitin synthase gene of Spodoptera exigua: molecular cloning and expression patterns
Insect Biochem. Mol. Biol.
37
409-417
2007
Spodoptera exigua (Q3I5Q4), Spodoptera exigua
Arakane, Y.; Specht, C.A.; Kramer, K.J.; Muthukrishnan, S.; Beeman, R.W.
Chitin synthases are required for survival, fecundity and egg hatch in the red flour beetle, Tribolium castaneum
Insect Biochem. Mol. Biol.
38
959-962
2008
Tribolium castaneum (Q6WD22), Tribolium castaneum (Q6WD23), Tribolium castaneum
Reyes, A.; Sanz, M.; Duran, A.; Roncero, C.
Chitin synthase III requires Chs4p-dependent translocation of Chs3p into the plasma membrane
J. Cell Sci.
120
1998-2009
2007
Saccharomyces cerevisiae (P29465), Saccharomyces cerevisiae
Broehan, G.; Zimoch, L.; Wessels, A.; Ertas, B.; Merzendorfer, H.
A chymotrypsin-like serine protease interacts with the chitin synthase from the midgut of the tobacco hornworm
J. Exp. Biol.
210
3636-3643
2007
Manduca sexta (Q530Z6), Manduca sexta
Plant, A.; Thompson, P.; Williams, D.M.
Stereoselective synthesis of novel uracil polyoxin C conjugates as substrate analogues of chitin synthase
J. Org. Chem.
73
3714-3724
2008
Saccharomyces cerevisiae, Candida albicans
Lenardon, M.D.; Whitton, R.K.; Munro, C.A.; Marshall, D.; Gow, N.A.
Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall
Mol. Microbiol.
66
1164-1173
2007
Candida albicans (A0A1D8PFK5), Candida albicans (P23316), Candida albicans (P30572), Candida albicans (P30573), Candida albicans
Werner, S.; Sugui, J.A.; Steinberg, G.; Deising, H.B.
A chitin synthase with a myosin-like motor domain is essential for hyphal growth, appressorium differentiation, and pathogenicity of the maize anthracnose fungus Colletotrichum graminicola
Mol. Plant Microbe Interact.
20
1555-1567
2007
Colletotrichum graminicola, Colletotrichum graminicola (Q8TFN5), Colletotrichum graminicola (Q8TFN6)
Nishihara, M.; Watanabe, A.; Asada, Y.
Isolation and characterization of the gene encoding a chitin synthase with a myosin motor-like domain from the edible basidiomycetous mushroom, Lentinula edodes, and its expression in the course of fruit-body formation
Mycoscience
48
109-116
2007
Lentinula edodes (A0PAB0)
Nishihara, M.; Watanabe, A.; Asada, Y.
Isolation, characterization, and expression analysis of a class IV chitin synthase gene from the edible basidiomycetous mushroom Pleurotus ostreatus
Mycoscience
48
176-181
2007
Pleurotus ostreatus
Hwang, E.I.; Lee, Y.M.; Lee, S.M.; Yeo, W.H.; Moon, J.S.; Kang, T.H.; Park, K.D.; Kim, S.U.
Inhibition of chitin synthase 2 and antifungal activity of lignans from the stem bark of Lindera erythrocarpa
Planta Med.
73
679-682
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae YPH499
Ke, S.; Liu, F.; Wang, N.; Yang, Q.; Qian, X.
1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation
Bioorg. Med. Chem. Lett.
19
332-335
2009
Saccharomyces cerevisiae
Cui, Z.; Ding, Z.; Yang, X.; Wang, K.; Zhu, T.
Gene disruption and characterization of a class V chitin synthase in Botrytis cinerea
Can. J. Microbiol.
55
1267-1274
2009
Botrytis cinerea
Kim, J.E.; Lee, H.J.; Lee, J.; Kim, K.W.; Yun, S.H.; Shim, W.B.; Lee, Y.W.
Gibberella zeae chitin synthase genes, GzCHS5 and GzCHS7, are required for hyphal growth, perithecia formation, and pathogenicity
Curr. Genet.
55
449-459
2009
Fusarium graminearum, Fusarium graminearum GZ03643
Fukuda, K.; Yamada, K.; Deoka, K.; Yamashita, S.; Ohta, A.; Horiuchi, H.
Class III chitin synthase ChsB of Aspergillus nidulans localizes at the sites of polarized cell wall synthesis and is required for conidial development
Eukaryot. Cell
8
945-956
2009
Aspergillus nidulans
Abramczyk, D.; Park, C.; Szaniszlo, P.J.
Cytolocalization of the class V chitin synthase in the yeast, hyphal and sclerotic morphotypes of Wangiella (Exophiala) dermatitidis
Fungal Genet. Biol.
46
28-41
2009
Exophiala dermatitidis (Q8TGV2)
Xu, Y.B.; Li, H.P.; Zhang, J.B.; Song, B.; Chen, F.F.; Duan, X.J.; Xu, H.Q.; Liao, Y.C.
Disruption of the chitin synthase gene CHS1 from Fusarium asiaticum results in an altered structure of cell walls and reduced virulence
Fungal Genet. Biol.
47
205-215
2010
Fusarium asiaticum
Maue, L.; Meissner, D.; Merzendorfer, H.
Purification of an active, oligomeric chitin synthase complex from the midgut of the tobacco hornworm
Insect Biochem. Mol. Biol.
39
654-659
2009
Manduca sexta
Souza, C.S.; Oliveira, B.M.; Costa, G.G.; Schriefer, A.; Selbach-Schnadelbach, A.; Uetanabaro, A.P.; Pirovani, C.P.; Pereira, G.A.; Taranto, A.G.; Cascardo, J.C.; Goes-Neto, A.
Identification and characterization of a class III chitin synthase gene of Moniliophthora perniciosa, the fungus that causes witches broom disease of cacao
J. Microbiol.
47
431-440
2009
Moniliophthora perniciosa (C0LT25), Moniliophthora perniciosa
Odenbach, D.; Thines, E.; Anke, H.; Foster, A.J.
The Magnaporthe grisea class VII chitin synthase is required for normal appressorial development and function
Mol. Plant Pathol.
10
81-94
2009
Pyricularia grisea (B5M4A8), Pyricularia grisea
Nino-Vega, G.A.; Sorais, F.; San-Blas, G.
Transcription levels of CHS5 and CHS4 genes in Paracoccidioides brasiliensis mycelial phase, respond to alterations in external osmolarity, oxidative stress and glucose concentration
Mycol. Res.
113
1091-1096
2009
Paracoccidioides brasiliensis (A9XTF8), Paracoccidioides brasiliensis (A9XTF9), Paracoccidioides brasiliensis
Walker, L.; Munro, C.; De Bruijn, I.; Lenardon, M.; McKinnon, A.; Gow, N.
Stimulation of chitin synthesis rescues Candida albicans from echinocandins
PLoS Pathog.
4
e1000040
2008
Candida albicans
Abramczyk, D.; Szaniszlo, P.J.
Immunoaffinity purification of the class V chitin synthase of Wangiella (Exophiala) dermatitidis
Prep. Biochem. Biotechnol.
39
277-288
2009
Exophiala dermatitidis (Q8TGV2)
Barreto, L.; Sorais, F.; Salazar, V.; San-Blas, G.; Nino-Vega, G.A.
Expression of Paracoccidioides brasiliensis CHS3 in a Saccharomyces cerevisiae chs3 null mutant demonstrates its functionality as a chitin synthase gene
Yeast
27
293-300
2009
Paracoccidioides brasiliensis (O94191), Paracoccidioides brasiliensis
Jimenez-Ortigosa, C.; Aimanianda, V.; Muszkieta, L.; Mouyna, I.; Alsteens, D.; Pire, S.; Beau, R.; Krappmann, S.; Beauvais, A.; Dufrene, Y.F.; Roncero, C.; Latge, J.P.
Chitin synthases with a myosin motor-like domain controls the resistance of Aspergillus fumigatus to echinocandins
Antimicrob. Agents Chemother.
56
6121-6131
2012
Aspergillus fumigatus
Magellan, H.; Drujon, T.; Thellend, A.; Piffeteau, A.; Becker, H.
Expression in E. coli and characterization of the catalytic domain of Botrytis cinerea chitin synthase
BMC Res. Notes
3
299
2010
Botrytis cinerea
Larson, T.M.; Kendra, D.F.; Busman, M.; Brown, D.W.
Fusarium verticillioides chitin synthases CHS5 and CHS7 are required for normal growth and pathogenicity
Curr. Genet.
57
177-189
2011
Fusarium verticillioides (D0VE03), Fusarium verticillioides (D0VE05), Fusarium verticillioides
Qu, M.; Yang, Q.
A novel alternative splicing site of class A chitin synthase from the insect Ostrinia furnacalis - gene organization, expression pattern and physiological significance
Insect Biochem. Mol. Biol.
41
923-931
2011
Ostrinia furnacalis (B4YIR0), Ostrinia furnacalis
Qu, M.; Yang, Q.
Physiological significance of alternatively spliced exon combinations of the single-copy gene class A chitin synthase in the insect Ostrinia furnacalis (Lepidoptera)
Insect Mol. Biol.
21
395-404
2012
Ostrinia furnacalis (Q2V6H3), Ostrinia furnacalis
Devrekanli, A.; Foltman, M.; Roncero, C.; Sanchez-Diaz, A.; Labib, K.
Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts
J. Cell Sci.
125
5453-5466
2012
Saccharomyces cerevisiae
Broeker, K.; Fehser, S.; Tenberge, K.; Moerschbacher, B.
Two class III chitin synthases specifically localized in appressoria and haustoria of Puccinia graminis f. sp. tritici
Physiol. Mol. Plant Pathol.
76
27-33
2011
Puccinia graminis f. sp. tritici (Q2XVY1), Puccinia graminis f. sp. tritici (Q2XVY2)
Treitschke, S.; Doehlemann, G.; Schuster, M.; Steinberg, G.
The myosin motor domain of fungal chitin synthase V is dispensable for vesicle motility but required for virulence of the maize pathogen Ustilago maydis
Plant Cell
22
2476-2494
2010
Ustilago maydis (Q4P9K9), Ustilago maydis
Guerriero, G.; Avino, M.; Zhou, Q.; Fugelstad, J.; Clergeot, P.H.; Bulone, V.
Chitin synthases from Saprolegnia are involved in tip growth and represent a potential target for anti-oomycete drugs
PLoS Pathog.
6
e1001070
2010
Saprolegnia monoica (D7NQS8), Saprolegnia monoica (D7NQS9), Saprolegnia monoica
Zhuo, W.; Chu, F.; Kong, L.; Tao, H.; Sima, Y.; Xu, S.
Chitin synthase B: a midgut-specific gene induced by insect hormones and involved in food intake in Bombyx mori larvae
Arch. Insect Biochem. Physiol.
85
36-47
2014
Bombyx mori (Q9GV28), Bombyx mori
Kral, K.; Bieg, T.; Nawrot, U.; W?odarczyk, K.; Lalik, A.; Hahn, P.; Wandzik, I.
New monomeric and dimeric uridinyl derivatives as inhibitors of chitin synthase
Bioorg. Chem.
61
13-20
2015
Saccharomyces cerevisiae
Ji, Q.; Yang, D.; Wang, X.; Chen, C.; Deng, Q.; Ge, Z.; Yuan, L.; Yang, X.; Liao, F.
Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents
Bioorg. Med. Chem.
22
3405-3413
2014
Saccharomyces cerevisiae, Saccharomyces cerevisiae CGMCC 2.145
Sheng, W.; Yamashita, S.; Ohta, A.; Horiuchi, H.
Functional differentiation of chitin synthases in Yarrowia lipolytica
Biosci. Biotechnol. Biochem.
77
1275-1281
2013
Yarrowia lipolytica, Yarrowia lipolytica CXAU1
Cui, Z.; Wang, Y.; Lei, N.; Wang, K.; Zhu, T.
Botrytis cinerea chitin synthase BcChsVI is required for normal growth and pathogenicity
Curr. Genet.
59
119-128
2013
Botrytis cinerea (Q5BNB8), Botrytis cinerea, Botrytis cinerea B05.10 (Q5BNB8)
Ji, Q.; Ge, Z.; Ge, Z.; Chen, K.; Wu, H.; Liu, X.; Huang, Y.; Yuan, L.; Yang, X.; Liao, F.
Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents
Eur. J. Med. Chem.
108
166-176
2016
Candida tropicalis
Gandia, M.; Harries, E.; Marcos, J.F.
The myosin motor domain-containing chitin synthase PdChsVII is required for development, cell wall integrity and virulence in the citrus postharvest pathogen Penicillium digitatum
Fungal Genet. Biol.
67
58-70
2014
Penicillium digitatum (R4I3H8), Penicillium digitatum, Penicillium digitatum CECT 20796 (R4I3H8)
Fajardo-Somera, R.A.; Joehnk, B.; Bayram, O.e.; Valerius, O.; Braus, G.H.; Riquelme, M.
Dissecting the function of the different chitin synthases in vegetative growth and sexual development in Neurospora crassa
Fungal Genet. Biol.
75
30-45
2015
Neurospora crassa (P29070), Neurospora crassa (P30588), Neurospora crassa (P30589), Neurospora crassa (Q01285), Neurospora crassa (Q7RVP6), Neurospora crassa (Q7S857), Neurospora crassa, Neurospora crassa DSM 1257 (P29070), Neurospora crassa DSM 1257 (P30588), Neurospora crassa DSM 1257 (P30589), Neurospora crassa DSM 1257 (Q01285), Neurospora crassa DSM 1257 (Q7RVP6), Neurospora crassa DSM 1257 (Q7S857)
Zhang, X.; Yan Zhu, K.
Biochemical characterization of chitin synthase activity and inhibition in the African malaria mosquito, Anopheles gambiae
Insect Sci.
20
158-166
2013
Anopheles gambiae
Gyore, J.; Parameswar, A.R.; Hebbard, C.F.; Oh, Y.; Bi, E.; Demchenko, A.V.; Price, N.P.; Orlean, P.
2-Acylamido analogues of N-acetylglucosamine prime formation of chitin oligosaccharides by yeast chitin synthase 2
J. Biol. Chem.
289
12835-12841
2014
Saccharomyces cerevisiae (P14180), Saccharomyces cerevisiae
Ge, Z.; Ji, Q.; Chen, C.; Liao, Q.; Wu, H.; Liu, X.; Huang, Y.; Yuan, L.; Liao, F.
Synthesis and biological evaluation of novel 3-substituted amino-4-hydroxylcoumarin derivatives as chitin synthase inhibitors and antifungal agents
J. Enzyme Inhib. Med. Chem.
31
219-228
2016
Cryptococcus neoformans
Weiss, I.M.; Lueke, F.; Eichner, N.; Guth, C.; Clausen-Schaumann, H.
On the function of chitin synthase extracellular domains in biomineralization
J. Struct. Biol.
183
216-225
2013
Atrina rigida (Q288C6)
Zhuo, W.; Fang, Y.; Kong, L.; Li, X.; Sima, Y.; Xu, S.
Chitin synthase A: a novel epidermal development regulation gene in the larvae of Bombyx mori
Mol. Biol. Rep.
41
4177-4186
2014
Bombyx mori (H6WW31), Bombyx mori
Cheng, W.; Lin, M.; Qiu, M.; Kong, L.; Xu, Y.; Li, Y.; Wang, Y.; Ye, W.; Dong, S.; He, S.; Wang, Y.
Chitin synthase is involved in vegetative growth, asexual reproduction and pathogenesis of Phytophthora capsici and Phytophthora sojae
Environ. Microbiol.
21
4537-4547
2019
Phytophthora sojae (A0A1V0HT57), Phytophthora sojae, Phytophthora capsici (Q01737), Phytophthora capsici, Phytophthora sojae P6497 (A0A1V0HT57), Phytophthora capsici JX1 (Q01737)
Noureldin, N.A.; Kothayer, H.; Lashine, E.M.; Baraka, M.M.; Huang, Y.; Li, B.; Ji, Q.
Design, synthesis and biological evaluation of novel quinazoline-2,4-diones conjugated with different amino acids as potential chitin synthase inhibitors
Eur. J. Med. Chem.
152
560-569
2018
Saccharomyces cerevisiae, Saccharomyces cerevisiae CGMCC2.145
Ji, Q.; Deng, Q.; Li, B.; Li, B.; Shen, Y.
Design, synthesis and biological evaluation of novel 5-(piperazin-1-yl)quinolin-2(1H)-one derivatives as potential chitin synthase inhibitors and antifungal agents
Eur. J. Med. Chem.
180
204-212
2019
Saccharomyces cerevisiae, Saccharomyces cerevisiae CGMCC 2.145
Li, B.; Shen, Y.; Wu, H.; Wu, X.; Yuan, L.; Ji, Q.
Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents
Eur. J. Med. Chem.
195
112278
2020
Candida tropicalis, Candida tropicalis ATCC 750
Brown, C.; Szpryngiel, S.; Kuang, G.; Srivastava, V.; Ye, W.; McKee, L.S.; Tu, Y.; Maeler, L.; Bulone, V.
Structural and functional characterization of the microtubule interacting and trafficking domains of two oomycete chitin synthases
FEBS J.
283
3072-3088
2016
Saprolegnia monoica (D7NQS8), Saprolegnia monoica (D7NQS9)
Fernandes, C.; Gow, N.; Goncalves, T.
The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi
Fungal Biol. Rev.
30
1-14
2016
Aspergillus fumigatus, Aspergillus nidulans, Aspergillus oryzae, Botrytis cinerea, Yarrowia lipolytica, Colletotrichum graminicola, Cryptococcus neoformans, Fusarium oxysporum, Fusarium verticillioides, Fusarium graminearum, Neurospora crassa, Pyricularia oryzae, Ustilago maydis, Exophiala dermatitidis, Penicillium digitatum
-
Rippert, D.; Heinisch, J.J.
Investigation of the role of four mitotic septins and chitin synthase 2 for cytokinesis in Kluyveromyces lactis
Fungal Genet. Biol.
94
69-78
2016
Kluyveromyces lactis, Kluyveromyces lactis KHO70
Salgado-Lugo, H.; Sanchez-Arreguin, A.; Ruiz-Herrera, J.
Heterologous expression of an active chitin synthase from Rhizopus oryzae
Fungal Genet. Biol.
97
10-17
2016
Rhizopus arrhizus
Xu, G.; Zhang, J.; Lyu, H.; Liu, J.; Ding, Y.; Feng, Q.; Song, Q.; Zheng, S.
BmCHSA-2b, a Lepidoptera specific alternative splicing variant of epidermal chitin synthase, is required for pupal wing development in Bombyx mori
Insect Biochem. Mol. Biol.
87
117-126
2017
Bombyx mori
Thammahong, A.; Caffrey-Card, A.K.; Dhingra, S.; Obar, J.J.; Cramer, R.A.
Aspergillus fumigatus trehalose-regulatory subunit homolog moonlights to mediate cell wall homeostasis through modulation of chitin synthase activity
mBio
8
e00056-17
2017
Aspergillus fumigatus, Aspergillus fumigatus CEA17
Klinter, S.; Bulone, V.; Arvestad, L.
Diversity and evolution of chitin synthases in oomycetes (Straminipila Oomycota)
Mol. Phylogenet. Evol.
139
106558
2019
Eurychasma dicksonii, Phytophthora infestans
Zhai, Y.; Fan, X.; Yin, Z.; Yue, X.; Men, X.; Zheng, L.; Zhang, W.
Identification and functional analysis of chitin synthase A in oriental armyworm, Mythimna separata
Proteomics
17
1700165
2017
Mythimna separata (A0A1I9RYC4), Mythimna separata
Liu, Z.; Zhang, X.; Liu, X.; Fu, C.; Han, X.; Yin, Y.; Ma, Z.
The chitin synthase FgChs2 and other FgChss co-regulate vegetative development and virulence in F. graminearum
Sci. Rep.
6
34975
2016
Fusarium graminearum, Fusarium graminearum PH-1
Wang, Z.; Yang, H.; Zhou, C.; Yang, W.J.; Jin, D.C.; Long, G.Y.
Molecular cloning, expression, and functional analysis of the chitin synthase 1 gene and its two alternative splicing variants in the white-backed planthopper, Sogatella furcifera (Hemiptera Delphacidae)
Sci. Rep.
9
1087
2019
Sogatella furcifera, Sogatella furcifera (A0A286QVM4), Sogatella furcifera (A0A286QVM7)
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